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3. High Positive End-expiratory Pressure (PEEP) with Recruitment Maneuvers versus Low PEEP during General Anesthesia for Surgery: A Bayesian Individual Patient Data Meta-analysis of Three Randomized Clinical Trials

Author

Mazzinari, Guido, Zampieri, Fernando G., Ball, Lorenzo, Campos, Niklas S., Bluth, Thomas, Hemmes, Sabrine N. T., Ferrando, Carlos, Librero, Julian, Soro, Marina, Pelosi, Paolo, Gama de Abreu, Marcelo, Schultz, Marcus J., Serpa Neto, Ary, Campos, Niklas S., Bluth, Thomas, Hemmes, Sabrine N.T., Ferrando, Carlos, Pelosi, Paolo, de Abreu, Marcelo Gama, Schultz, Marcus J., Neto, Ary Serpa, Campos, Niklas S., Bluth, Thomas, Hemmes, Sabrine N.T., Librero, Julian, Pozo, Natividad, Ferrando, Carlos, Ball, Lorenzo, Mazzinari, Guido, Pelosi, Paolo, de Abreu, Marcelo Gama, Schultz, Marcus J., Neto, Ary Serpa, Hemmes, Sabrine N.T., Gama de Abreu, Marcelo, Severgnini, Paolo, Hollmann, Markus W., Binnekade, Jan M., Wrigge, Hermann, Canet, Jaume, Hiesmayr, Michael, Schmid, Werner, Tschernko, Edda, Jaber, Samir, Hedenstierna, Göran, Putensen, Christian, Pelosi, Paolo, Schultz, Marcus J., Marti, Agnes, Bacuzzi, Alessandro, Brodhun, Alexander, Molin, Alexandre, Merten, Alfred, Parera, Ana, Brunelli, Andrea, Cortegiani, Andrea, Güldner, Andreas, Reske, Andreas W., Gratarola, Angelo, Giarratano, Antonino, Bastin, Bea, Heyse, Bjorn, Mazul-Sunko, Branka, Amantea, Bruno, Barberis, Bruno, Putensen, Christian, Uhlig, Christopher, Minguez Marín, Conrado, Celentano, Cristian, La Bella, Daniela, D’Antini, David, Velghe, David, Sulemanji, Demet, De Robertis, Edoardo, Hartmann, Eric, Montalto, Francesca, Tropea, Francesco, Mills, Gary H., Cinnella, Gilda, Rocca, Giorgio Della, Caggianelli, Girolamo, Pellerano, Giulia, Mollica, Giuseppina, Bugedo, Guillermo, Wrigge, Hermann, Mulier, Jan-Paul, Vandenbrande, Jeroen, Geib, Johann, Yaqub, Jonathan, Florez, Jorge, Mayoral, Juan F., Sprung, Juraj, Van Limmen, Jurgen, Bos, Lieuwe D.J., de Baerdemaeker, Luc, Jamaer, Luc, Spagnolo, Luigi, Strys, Lydia, Granell Gil, Manuel, de Abreu, Marcelo Gama, Vidal Melo, Marcos F., Schultz, Marcus J., Unzueta, Maria Carmen, Moral, Maria Victoria, Ferner, Marion, Hollmann, Markus W., Weiss, Martin, Vanoni, Massimo, Schaefer, Maximilian S., Prieto, Mercè, Grio, Michele, Severgnini, Paolo, Spieth, Peter Markus, Simon, Philipp, Bodger, Phoebe, Sierra, Pilar, Laufenberg-Feldmann, Rita, Rusca, Roberta, Proietti, Rodolfo, Hemmes, Sabrine N.T., Raineri, Santi Maurizio, Caroleo, Santo, Sabaté, Sergi, De Hert, Stefan, Pezzato, Stefano, Treschan, Tanja A., Goranovic, Tatjana, Koch, Thea, Bluth, Thomas, Kiss, Thomas, Perilli, Valter, Cegarra, Virginia, Schmid, Werner, Ferrando, Carlos, Belda, Javier, Soro, Marina, Canet, Jaume, Unzueta, Carmen, Suarez-Sipmann, Fernando, Librero, Julián, Llombart, Alicia, Rovira, Lucas, Granell, Manuel, Aldecoa, César, Diaz-Cambronero, Oscar, Balust, Jaume, Garutti, Ignacio, Gonzalez, Rafael, Gallego, Lucia, del Valle, Santiago Garcia, Redondo, Javier, Pestaña, David, Rodríguez, Aurelio, García, Javier, de la Matta, Manuel, Ibáñez, Maite, Barrios, Francisco, Hernández, Samuel, Torres, Vicente, Peiró, Salvador, Pozo, Natividad, Villena, Abigail, Carramiñana, Albert, Gallego-Casilda, Alberto, Duca, Alejandro, Alcón, Amalia, Miñana, Amanda, Asensio, Ana, Colás, Ana, Isabel Galve, Ana, Izquierdo, Ana, Jurado, Ana, María Pérez, Ana, Mugarra, Ana, Parera, Ana, Brunelli, Andrea, Gutierrez, Andrea, De Miguel, Ángeles, Lozano, Angels, Katime, Antonio, Romero, Antonio, Garrigues, Beatriz, Ayas, Begoña, Arocas, Blanca, Delgado, Carlos, Fernández, Carmen, Romero, Carolina, Gallego, Clara, Garcés, Cristina, Lisbona, Cristina, Parrilla, Cristina, López-Herrera, Daniel, González, Domingo, Llamazares, Eduardo, Del Rio, Elena, Lozano, Elena, Pastor, Ernesto, Chamorro, Estefanía, Gracia, Estefanía, Sánchez, Ester, Romero, Esther, Díez, Fernando, Serralta, Ferran, Daviu, Francisco, Sandín, Francisco, Aguilar, Gerardo, Tusman, Gerardo, Azparren, Gonzalo, Martínez-Pallí, Graciela, Mazzinari, Guido, Benítez, Inmaculada, Hernandéz, Inmaculada, India, Inmaculada, León, Irene, Fuentes, Isabel, Ruiz, Isabel, Puig, Jaume, Ignacio Román, Javie, Acosta, Jesús, Rico, Jesús, Olmedo, Jonathan, Carbonell, Jose A., Alonso, Jose M., María Pérez, Jose, Miguel Marcos, Jose, Navarro, Jose, Valdivia, Jose, Carrizo, Juan, Piqueras, Laura, Soriano, Laura, Vaquero, Laura, Miguel, Lisset, Muñoz, Lorena, Valencia, Lucia, Olmedilla, Luis, Etulain, Ma Justina, Tisner, Manuel, Barrio, María, Dolores Alonso, María, García, María, Hernández, María J., José Alberola, María, Parra, María, Pilar Argente, María, Vila, María, De Fez, Mario, Agilaga, Marta, Gine, Marta, Ayuso, Mercedes, García, Mercedes, Bejarano, Natalia, Peña, Natalia, Ojeda, Nazario, Martínez, Nilda, García, Nuria, Padrón, Oto, García, Pablo, Valls, Paola, Cruz, Patricia, Piñeiro, Patricia, Charco, Pedro, Anaya, Rafael, López, Ramiro, Rodríguez, Rayco, Martínez, Rocío, Pujol, Roger, Dosdá, Rosa, Lardies, Rosa, Díaz, Ruben, Villazala, Rubén, Zapatero, Sara, Cabrera, Sergio, Sánchez, Sergio, Martin, Silvia, Diaz, Suzana, Franco, Tania, Moreno, Tania, Socorro, Tania, Gilabert, Vicente, Balandrón, Victor, Moral, Victoria, Cegarra, Virgina, Varón, Viviana, Bluth, Thomas, Serpa Neto, Ary, Bobek, Ilona, Canet, Jaume, Cinnella, Gilda, de Baerdemaeker, Luc, Gregoretti, Cesare, Hedenstierna, Göran, Hemmes, Sabrine N.T., Hiesmayr, Michael, Hollmann, Markus W., Jaber, Samir, Laffey, John, Licker, Marc-Joseph, Markstaller, Klaus, Matot, Idit, Mills, Gary H., Mulier, Jan Paul, Putensen, Christian, Rossaint, Rolf, Schmitt, Jochen, Senturk, Mert, Severgnini, Paolo, Sprung, Juraj, Vidal Melo, Marcos F., Wrigge, Hermann, Schultz, Marcus J., Pelosi, Paolo, de Abreu, Marcelo Gama, Abelha, Fernando, Abitağaoğlu, Sühayla, Achilles, Marc, Adebesin, Afeez, Adriaensens, Ine, Ahene, Charles, Akbar, Fatima, Al Harbi, Mohammed, Al Khoury al Kallab, Rita, Albanel, Xavier, Aldenkortt, Florence, Alfouzan, Rawan Abdullah Saleh, Alruqaie, Reef, Altermatt, Fernando, Araujo, Bruno Luís de Castro, Arbesú, Genaro, Artsi, Hanna, Aurilio, Caterina, Ayanoglu, Omer Hilmi, Bacuzzi, Alessandro, Baig, Harris, Baird, Yolanda, Balonov, Konstantin, Balust, Jaume, Banks, Samantha, Bao, Xiaodong, Baumgartner, Mélanie, Belda Tortosa, Isabel, Bergamaschi, Alice, Bergmann, Lars, Bigatello, Luca, Biosca Pérez, Elena, Birr, Katja, Bluth, Thomas, Bojaxhi, Elird, Bonenti, Chiara, Bonney, Iwona, Bos, Elke M.E., Bowman, Sara, Braz, Leandro Gobbo, Brugnoni, Elisa, Brull, Sorin J., Brunetti, Iole, Bruni, Andrea, Buenvenida, Shonie L., Busch, Cornelius Johannes, Camerini, Giovanni, Canet, Jaume, Capatti, Beatrice, Carmona, Javiera, Carungcong, Jaime, Carvalho, Marta, Cattan, Anat, Cavaleiro, Carla, Chiumello, Davide, Ciardo, Stefano, Coburn, Mark, Colella, Umberto, Contreras, Victor, Corman Dincer, Pelin, Cotter, Elizabeth, Crovetto, Marcia, Darrah, William, Davies, Simon, de Baerdemaeker, Luc, De Hert, Stefan, Del Cojo Peces, Enrique, Delphin, Ellise, Diaper, John, do Nascimento, Paulo, Jr., Donatiello, Valerio, Dong, Jing, Dourado, Maria do Socorro, Dullenkopf, Alexander, Ebner, Felix, Elgendy, Hamed, Ellenberger, Christoph, Erdoğan Ari, Dilek, Ermert, Thomas, Farah, Fadi, Fernandez-Bustamante, Ana, Ferreira, Cristina, Fiore, Marco, Fonte, Ana, Fortià Palahí, Christina, Galimberti, Andrea, Gama de Abreu, Marcelo, Garofano, Najia, Giaccari, Luca Gregorio, Gilsanz, Fernando, Girrbach, Felix, Gobbi, Luca, Godfried, Marc Bernard, Goettel, Nicolai, Goldstein, Peter A., Goren, Or, Gorlin, Andrew, Granell Gil, Manuel, Gratarola, Angelo, Graterol, Juan, Guyon, Pierre, Haire, Kevin, Harou, Philippe, Helf, Antonia, Hemmes, Sabrine N.T., Hempel, Gunther, Hernández Cádiz, María José, Heyse, Björn, Hollmann, Markus W., Huercio, Ivan, Ilievska, Jasmina, Jakus, Lien, Jeganath, Vijay, Jelting, Yvonne, Jung, Minoa, Kabon, Barbara, Kacha, Aalok, Karaman Ilić, Maja, Karuppiah, Arunthevaraja, Kavas, Ayse Duygu, Keli Barcelos, Gleicy, Kellogg, Todd A., Kemper, Johann, Kerbrat, Romain, Khodr, Suraya, Kienbaum, Peter, Kir, Bunyamin, Kiss, Thomas, Kivrak, Selin, Klarić, Vlasta, Koch, Thea, Köksal, Ceren, Kowark, Ana, Kranke, Peter, Kuvaki, Bahar, Kuzmanovska, Biljana, Laffey, John, Lange, Mirko, Lemos, Marília Freitas de, Licker, Marc-Joseph, López-Baamonde, Manuel, López-Hernández, Antonio, Lopez-Martinez, Mercedes, Luise, Stéphane, MacGregor, Mark, Machado, Humberto S., Magalhães, Danielle, Maillard, Julien, Malerbi, Patrizia, Manimekalai, Natesan, Margarson, Michael, Markstaller, Klaus, Martin, Archer K, Martin, David P., Martin, Yvette N., Martínez-Ocon, Julia, Martin-Loeches, Ignacio, Maseda, Emilio, Matot, Idit, McAuliffe, Niamh, McKenzie, Travis J., Medina, Paulina, Meersch, Melanie, Menzen, Angelika, Mertens, Els, Meurer, Bernd, Meyer-Treschan, Tanja, Miao, Changhong, Micalizzi, Camilla, Milić, Morena, Módolo, Norma Sueli Pinheiro, Moine, Pierre, Mölders, Patrick, Montero-Feijoo, Ana, Moret, Enrique, Muller, Markus K, Murphy, Zoe, Nalwaya, Pramod, Filip, Naumovski, Navalesi, Paolo, Navarro e Lima, Lais Helena, Nesek Adam, Višnja, Neumann, Claudia, Newell, Christopher, Nisnevitch, Zoulfira, Nizamuddin, Junaid, Novazzi, Cecilia, Nunes, Catarina S, O’Connor, Michael, Oprea, Günther, Orhan Sungur, Mukadder, Özbilgin, Şule, Pace, Maria Caterina, Pacheco, Marcos, Packianathaswamy, Balaji, Palma Gonzalez, Estefania, Papaspyros, Fotios, Paredes, Sebastián, Passavanti, Maria Beatrice, Pedemonte, Juan Cristobal, Pelosi, Paolo, Peremin, Sanja, Philipsenburg, Christoph, Pinho, Daniela, Pinho, Silvia, Posthuma, Linda M., Pota, Vincenzo, Preckel, Benedikt, Priani, Paolo, Putensen, Christian, Rached, Mohamed Aymen, Radoeshki, Aleksandar, Ragazzi, Riccardo, Rajamanickam, Tamilselvan, Rajamohan, Arthi, Ramakrishna, Harish, Rangarajan, Desikan, Reiterer, Christian, Renew, J. Ross, Reynaud, Thomas, Rhys, Rhidian, Rivas, Eva, Robitzky, Luisa, Rossaint, Rolf, Rubulotta, Francesca, Sabbatini, Giovanni, Samuels, Jon D, Sanahuja, Josep Martí, Sansone, Pasquale, Santos, Alice, Sayedalahl, Mohamed, Schaefer, Maximilian S., Scharffenberg, Martin, Schiffer, Eduardo, Schliewe, Nadja, Schorer, Raoul, Schultz, Marcus J., Schumann, Roman, Selmo, Gabriele, Sendra, Mar, Senturk, Mert, Severgnini, Paolo, Shaw, Kate, Shosholcheva, Mirjana, Sibai, Abdulrazak, Simon, Philipp, Simonassi, Francesca, Sinno, Claudia, Sivrikoz, Nukhet, Skandalou, Vasiliki, Smith, Neil, Soares, Maria, Socorro Artiles, Tania, Sousa Castro, Diogo, Sousa, Miguel, Spadaro, Savino, Sprung, Juraj, Stamatakis, Emmanouil, Steiner, Luzius A., Stevenazzi, Andrea, Suarez-de-la-Rica, Alejandro, Suppan, Mélanie, Teichmann, Robert, Tena Guerrero, José Maria, Thiel, Bram, Tolós, Raquel, Tucci, Michelle, Turnbull, Zachary A., Turudić, Žana, Unterberg, Matthias, Van Limmen, Jurgen, Van Nieuwenhove, Yves, Van Waesberghe, Julia, Vidal Melo, Marcos Francisco, Vitković, Bibiana, Vivona, Luigi, Vizcaychipi, Marcela, Volta, Carlo Alberto, Weber, Anne, Weingarten, Toby N., Wittenstein, Jakob, Wrigge, Hermann, Wyffels, Piet, Yagüe, Julio, Yates, David, Yavru, Ayşen, Zac, Lilach, and Zhong, Jing

Published
2025
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4. Burden of severe infections due to carbapenem-resistant pathogens in intensive care unit.

Author

Pace, Maria Caterina, Corrente, Antonio, Passavanti, Maria Beatrice, Sansone, Pasquale, Petrou, Stephen, Leone, Sebastiano, and Fiore, Marco

Subjects
Antimicrobial resistance, Carbapenem-resistance, Intensive care unit, Multidisciplinary critical care, Multidrug-resistant, PDR, Vaccine Related, Antimicrobial Resistance, Patient Safety, Prevention, Biodefense, Infectious Diseases, Emerging Infectious Diseases, 2.2 Factors relating to the physical environment, Aetiology, Infection, Good Health and Well Being
Abstract

Intensive care units (ICU) for various reasons, including the increasing age of admitted patients, comorbidities, and increasingly complex surgical procedures (e.g., transplants), have become "the epicenter" of nosocomial infections, these are characterized by the presence of multidrug-resistant organisms (MDROs) as the cause of infection. Therefore, the perfect match of fragile patients and MDROs, as the cause of infection, makes ICU mortality very high. Furthermore, carbapenems were considered for years as last-resort antibiotics for the treatment of infections caused by MDROs; unfortunately, nowadays carbapenem resistance, mainly among Gram-negative pathogens, is a matter of the highest concern for worldwide public health. This comprehensive review aims to outline the problem from the intensivist's perspective, focusing on the new definition and epidemiology of the most common carbapenem-resistant MDROs (Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacterales) to emphasize the importance of the problem that must be permeating clinicians dealing with these diseases.

Published
2023

6. Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical trials

Author

Hemmes, Sabrine NT., Gama de Abreu, Marcelo, Severgnini, Paolo, Hollmann, Markus W., Binnekade, Jan M., Wrigge, Hermann, Canet, Jaume, Hiesmayr, Michael, Schmid, Werner, Tschernko, Edda, Jaber, Samir, Hedenstierna, Göran, Putensen, Christian, Pelosi, Paolo, Schultz, Marcus J., Marti, Agnes, Bacuzzi, Alessandro, Brodhun, Alexander, Molin, Alexandre, Merten, Alfred, Parera, Ana, Brunelli, Andrea, Cortegiani, Andrea, Güldner, Andreas, Reske, Andreas W., Gratarola, Angelo, Giarratano, Antonino, Bastin, Bea, Heyse, Bjorn, Mazul-Sunko, Branka, Amantea, Bruno, Barberis, Bruno, Uhlig, Christopher, Marín, Conrado Minguez, Celentano, Cristian, La Bella, Daniela, D’Antini, David, Velghe, David, Sulemanji, Demet, De Robertis, Edoardo, Hartmann, Eric, Montalto, Francesca, Tropea, Francesco, Mills, Gary H., Cinnella, Gilda, Della Rocca, Giorgio, Caggianelli, Girolamo, Pellerano, Giulia, Mollica, Giuseppina, Bugedo, Guillermo, Mulier, Jan-Paul, Vandenbrande, Jeroen, Geib, Johann, Yaqub, Jonathan, Florez, Jorge, Mayoral, Juan F., Sprung, Juraj, Van Limmen, Jurgen, Bos, Lieuwe DJ., de Baerdemaeker, Luc, Jamaer, Luc, Spagnolo, Luigi, Strys, Lydia, Gil, Manuel Granell, Vidal Melo, Marcos F., Unzueta, Maria Carmen, Moral, Maria Victoria, Ferner, Marion, Weiss, Martin, Vanoni, Massimo, Schaefer, Maximilian S., Prieto, Mercè, Grio, Michele, Spieth, Peter Markus, Simon, Philipp, Bodger, Phoebe, Sierra, Pilar, Laufenberg-Feldmann, Rita, Rusca, Roberta, Proietti, Rodolfo, Raineri, Santi Maurizio, Caroleo, Santo, Sabaté, Sergi, De Hert, Stefan, Pezzato, Stefano, Treschan, Tanja A., Goranovic, Tatjana, Koch, Thea, Bluth, Thomas, Kiss, Thomas, Perilli, Valter, Cegarra, Virginia, Ferrando, Carlos, Belda, Javier, Soro, Marina, Unzueta, Carmen, Suarez-Sipmann, Fernando, Librero, Julián, Llombart, Alicia, Rovira, Lucas, Granell, Manuel, Aldecoa, César, Diaz-Cambronero, Oscar, Balust, Jaume, Garutti, Ignacio, Gonzalez, Rafael, Gallego, Lucia, Garcia del Valle, Santiago, Redondo, Javier, Pestaña, David, Rodríguez, Aurelio, García, Javier, Matta, Manuel de la, Ibáñez, Maite, Barrios, Francisco, Hernández, Samuel, Torres, Vicente, Peiró, Salvador, Pozo, Natividad, Villena, Abigail, Carramiñana, Albert, Gallego-Casilda, Alberto, Duca, Alejandro, Alcón, Amalia, Miñana, Amanda, Asensio, Ana, Colás, Ana, Galve, Ana Isabel, Izquierdo, Ana, Jurado, Ana, Pérez, Ana María, Mugarra, Ana, Gutierrez, Andrea, De Miguel, Ángeles, Lozano, Angels, Katime, Antonio, Romero, Antonio, Garrigues, Beatriz, Ayas, Begoña, Arocas, Blanca, Delgado, Carlos, Fernández, Carmen, Romero, Carolina, Gallego, Clara, Garcés, Cristina, Lisbona, Cristina, Parrilla, Cristina, López-Herrera, Daniel, González, Domingo, Llamazares, Eduardo, Del Rio, Elena, Lozano, Elena, Pastor, Ernesto, Chamorro, Estefanía, Gracia, Estefanía, Sánchez, Ester, Romero, Esther, Díez, Fernando, Serralta, Ferran, Daviu, Francisco, Sandín, Francisco, Aguilar, Gerardo, Tusman, Gerardo, Azparren, Gonzalo, Martínez-Pallí, Graciela, Mazzinari, Guido, Benítez, Inmaculada, Hernandéz, Inmaculada, India, Inmaculada, León, Irene, Fuentes, Isabel, Ruiz, Isabel, Puig, Jaume, Román, Javie Ignacio, Acosta, Jesús, Rico-Feijoo, Jesús, Olmedo, Jonathan, Carbonell, Jose A., Alonso, Jose M., Pérez, Jose María, Marcos, Jose Miguel, Navarro, Jose, Valdivia, Jose, Carrizo, Juan, Piqueras, Laura, Soriano, Laura, Vaquero, Laura, Miguel, Lisset, Muñoz, Lorena, Valencia, Lucia, Olmedilla, Luis, Etulain, Mᵃ Justina, Tisner, Manuel, Barrio, María, Alonso, María Dolores, García, María, Hernández, María J., Alberola, María José, Parra, María, Argente, María Pilar, Vila, María, De Fez, Mario, Agilaga, Marta, Gine, Marta, Ayuso, Mercedes, García, Mercedes, Bejarano, Natalia, Peña, Natalia, Ojeda, Nazario, Martínez, Nilda, García, Nuria, Padrón, Oto, García, Pablo, Valls, Paola, Cruz, Patricia, Piñeiro, Patricia, Charco, Pedro, Anaya, Rafael, López, Ramiro, Rodríguez, Rayco, Martínez, Rocío, Pujol, Roger, Dosdá, Rosa, Lardies, Rosa, Díaz, Ruben, Villazala, Rubén, Zapatero, Sara, Cabrera, Sergio, Sánchez, Sergio, Martin, Silvia, Diaz, Suzana, Franco, Tania, Moreno, Tania, Socorro, Tania, Gilabert, Vicente, Balandrón, Victor, Moral, Victoria, Cegarra, Virgina, Varón, Viviana, Abelha, Fernando, Abitağaoğlu, Sühayla, Achilles, Marc, Adebesin, Afeez, Adriaensens, Ine, Ahene, Charles, Akbar, Fatima, Al Harbi, Mohammed, Al Khoury al Kallab, Rita, Albanel, Xavier, Aldenkortt, Florence, Saleh Alfouzan, Rawan Abdullah, Alruqaie, Reef, Altermatt, Fernando, Luís de Castro Araujo, Bruno, Arbesú, Genaro, Artsi, Hanna, Aurilio, Caterina, Ayanoglu, Omer Hilmi, Baig, Harris, Baird, Yolanda, Balonov, Konstantin, Banks, Samantha, Bao, Xiaodong, Baumgartner, Mélanie, Tortosa, Isabel Belda, Bergamaschi, Alice, Bergmann, Lars, Bigatello, Luca, Pérez, Elena Biosca, Birr, Katja, Bojaxhi, Elird, Bonenti, Chiara, Bonney, Iwona, Bos, Elke M.E., Bowman, Sara, Braz, Leandro Gobbo, Brugnoni, Elisa, Brull, Sorin J., Brunetti, Iole, Bruni, Andrea, Buenvenida, Shonie L., Busch, Cornelius Johannes, Camerini, Giovanni, Capatti, Beatrice, Carmona, Javiera, Carungcong, Jaime, Carvalho, Marta, Cattan, Anat, Cavaleiro, Carla, Chiumello, Davide, Ciardo, Stefano, Coburn, Mark, Colella, Umberto, Contreras, Victor, Dincer, Pelin Corman, Cotter, Elizabeth, Crovetto, Marcia, Darrah, William, Davies, Simon, Del Cojo Peces, Enrique, Delphin, Ellise, Diaper, John, Junior, Paulo do Nascimento, Donatiello, Valerio, Dong, Jing, Dourado, Maria do Socorro, Dullenkopf, Alexander, Ebner, Felix, Elgendy, Hamed, Ellenberger, Christoph, Arı, Dilek Erdoğan, Ermert, Thomas, Farah, Fadi, Fernandez-Bustamante, Ana, Ferreira, Cristina, Fiore, Marco, Fonte, Ana, Palahí, Christina Fortià, Galimberti, Andrea, Garofano, Najia, Giaccari, Luca Gregorio, Gilsanz, Fernando, Girrbach, Felix, Gobbi, Luca, Godfried, Marc Bernard, Goettel, Nicolai, Goldstein, Peter A., Goren, Or, Gorlin, Andrew, Graterol, Juan, Guyon, Pierre, Haire, Kevin, Harou, Philippe, Helf, Antonia, Hemmes, Sabrine N.T., Hempel, Gunther, Hernández Cádiz, María José, Heyse, Björn, Huercio, Ivan, Ilievska, Jasmina, Jakus, Lien, Jeganath, Vijay, Jelting, Yvonne, Jung, Minoa, Kabon, Barbara, Kacha, Aalok, Ilić, Maja Karaman, Karuppiah, Arunthevaraja, Kavas, Ayse Duygu, Barcelos, Gleicy Keli, Kellogg, Todd A., Kemper, Johann, Kerbrat, Romain, Khodr, Suraya, Kienbaum, Peter, Kir, Bunyamin, Kivrak, Selin, Klarić, Vlasta, Köksal, Ceren, Kowark, Ana, Kranke, Peter, Kuvaki, Bahar, Kuzmanovska, Biljana, Laffey, John, Lange, Mirko, Freitas de Lemos, Marília, Licker, Marc-Joseph, López-Baamonde, Manuel, López-Hernández, Antonio, Lopez-Martinez, Mercedes, Luise, Stéphane, MacGregor, Mark, Magalhães, Danielle, Maillard, Julien, Malerbi, Patrizia, Manimekalai, Natesan, Margarson, Michael, Markstaller, Klaus, Martin, Archer K., Martin, David P., Martin, Yvette N., Martínez-Ocon, Julia, Martin-Loeches, Ignacio, Maseda, Emilio, Matot, Idit, McAuliffe, Niamh, McKenzie, Travis J., Medina, Paulina, Meersch, Melanie, Menzen, Angelika, Mertens, Els, Meurer, Bernd, Meyer-Treschan, Tanja, Miao, Changhong, Micalizzi, Camilla, Milić, Morena, Pinheiro Módolo, Norma Sueli, Moine, Pierre, Mölders, Patrick, Montero-Feijoo, Ana, Moret, Enrique, Muller, Markus K., Murphy, Zoe, Nalwaya, Pramod, Naumovski, Filip, Navalesi, Paolo, Navarro e Lima, Lais Helena, Adam, Višnja Nesek, Neumann, Claudia, Newell, Christopher, Nisnevitch, Zoulfira, Nizamuddin, Junaid, Novazzi, Cecilia, O'Connor, Michael, Oprea, Günther, Sungur, Mukadder Orhan, Özbilgin, Şule, Pace, Maria Caterina, Pacheco, Marcos, Packianathaswamy, Balaji, Gonzalez, Estefania Palma, Papaspyros, Fotios, Paredes, Sebastián, Passavanti, Maria Beatrice, Pedemonte, Juan Cristobal, Peremin, Sanja, Philipsenburg, Christoph, Pinho, Daniela, Pinho, Silvia, Posthuma, Linda M., Pota, Vincenzo, Preckel, Benedikt, Priani, Paolo, Rached, Mohamed Aymen, Radoeshki, Aleksandar, Ragazzi, Riccardo, Rajamanickam, Tamilselvan, Rajamohan, Arthi, Ramakrishna, Harish, Rangarajan, Desikan, Reiterer, Christian, Renew, J. Ross, Reynaud, Thomas, Rhys, Rhidian, Rivas, Eva, Robitzky, Luisa, Rossaint, Rolf, Rubulotta, Francesca, Machado, Humberto S., Nunes, Catarina S., Sabbatini, Giovanni, Samuels, Jon D., Sanahuja, Josep Martí, Sansone, Pasquale, Santos, Alice, Sayedalahl, Mohamed, Scharffenberg, Martin, Schiffer, Eduardo, Schliewe, Nadja, Schorer, Raoul, Schumann, Roman, Selmo, Gabriele, Sendra, Mar, Senturk, Mert, Shaw, Kate, Shosholcheva, Mirjana, Sibai, Abdulrazak, Simonassi, Francesca, Sinno, Claudia, Sivrikoz, Nukhet, Skandalou, Vasiliki, Smith, Neil, Soares, Maria, Artiles, Tania Socorro, Castro, Diogo Sousa, Sousa, Miguel, Spadaro, Savino, Stamatakis, Emmanouil, Steiner, Luzius A., Stevenazzi, Andrea, Suarez-de-la-Rica, Alejandro, Suppan, Mélanie, Teichmann, Robert, Tena Guerrero, José Maria, Thiel, Bram, Tolós, Raquel, Altun, Gulbin Tore, Tucci, Michelle, Turnbull, Zachary A., Turudić, Žana, Unterberg, Matthias, Van Nieuwenhove, Yves, Van Waesberghe, Julia, Vidal Melo, Marcos Francisco, Vitković, Bibiana, Vivona, Luigi, Vizcaychipi, Marcela, Volta, Carlo Alberto, Weber, Anne, Weingarten, Toby N., Wittenstein, Jakob, Wyffels, Piet, Yagüe, Julio, Yates, David, Yavru, Ayşen, Zac, Lilach, Zhong, Jing, Campos, Niklas S., Librero, Julian, Ball, Lorenzo, and Serpa Neto, A.

Published
2022
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7. The Role of Corticosteroids in Non-Bacterial and Secondary Encephalitis.

Author

Di Flumeri, Giusy, Giaccari, Luca Gregorio, Pace, Maria Caterina, Passavanti, Maria Beatrice, Pota, Vincenzo, Riccardi, Vincenzo, Brunetti, Simona, Sansone, Pasquale, Coppolino, Francesco, and Aurilio, Caterina

Subjects
CENTRAL nervous system diseases, VIRAL encephalitis, ENCEPHALITIS, DEATH rate, MENINGITIS
Abstract

Encephalitis affects 1.9 to 14.3 people per 100,000 each year, and the mortality rate varies but can be up to 40%. After the identification of a particular microorganism in a patient with encephalitis, appropriate antimicrobial therapy should be initiated. Corticosteroid therapy represents a therapeutic option in the treatment of primary central nervous system diseases due to its ability to reduce the inflammatory commitment of CNS and consequently reduce mortality rates regardless of the causative agent of injury. Corticosteroid therapy represents a therapeutic option in the treatment of primary central nervous system diseases. Their use is also recommended in meningitis with autoimmune etiology. While corticosteroids have repeatedly been used as adjunctive treatment in encephalitis of viral etiology, the scientific evidence supporting their effectiveness remains scarce. The use of standard doses recommended by the guidelines seems reasonable as an initial setting, especially when a definitive diagnosis of the causal agent is still awaited. The subsequent adjustment should be personalized based on the individual clinical response. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Dexmedetomidine as Adjunctive Therapy for the Treatment of Alcohol Withdrawal Syndrome: A Systematic Review and Meta-Analysis.

Author

Fiore, Marco, Alfieri, Aniello, Torretta, Giacomo, Passavanti, Maria Beatrice, Sansone, Pasquale, Pota, Vincenzo, Simeon, Vittorio, Chiodini, Paolo, Corrente, Antonio, and Pace, Maria Caterina

Subjects
ALCOHOL withdrawal syndrome, TERMINATION of treatment, TRACHEA intubation, ALCOHOL drinking, RESPIRATORY insufficiency
Abstract

Alcohol withdrawal syndrome (AWS) is defined as the cessation or reduction in heavy and prolonged alcohol use within several hours to a few days of cessation. The recommended first-line therapy for AWS ranging from mild to severe or complicated remains benzodiazepines; in cases where benzodiazepines are not adequate in controlling persistent autonomic hyperactivity or anxiety, dexmedetomidine could be utilized. The possible advantage of dexmedetomidine compared to benzodiazepines is that it does not cause respiratory depression, thus reducing the risk of intubation and hospitalization in the ICUs, with the potential reduction in healthcare costs. The purpose of this systematic review and meta-analysis (PROSPERO CRD42018084370) is to evaluate the effectiveness and safety of dexmedetomidine as adjunctive therapy to the standard of care for the treatment of AWS. We retrieved literature from PubMed, EMBASE, and CENTRAL until 10 January 2024. Eligible studies were both randomized trials and nonrandomised studies with a control group, published in the English language and peer-reviewed journals. The primary outcome was tracheal intubation; secondary outcomes were (i) bradycardia and (ii) hypotension. A total of 3585 papers were retrieved: 2635 from EMBASE, 930 from Medline, and 20 from CENTRAL. After eliminating duplicates, 2960 papers were screened by title and abstract; 75 out of the 2960 papers were read in full text. The qualitative synthesis included nine of all manuscripts read in full text. The quantitative synthesis included eight studies for the primary outcome (tracheal intubation), seven for the secondary outcome bradycardia, and six for the secondary outcome hypotension. The meta-analysis showed that Dexmedetomidine, as adjunctive therapy, is not more effective than standard therapy in reducing the risk of tracheal intubation in AWS [RR: 0.57, 95% CI: 0.25–1.3, p = 0.15]. It also appears to be less safe than sedative therapy as it significantly increases the risk of bradycardia [RR: 2.68, 95% CI: 1.79–4.16, p = 0.0016]. Hypotension was not significantly different in patients who received dexmedetomidine [RR: 1.5, 95% CI: 0.69–3.49, p = 0.21]. [ABSTRACT FROM AUTHOR]

Published
2024
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17. COVID-19 in Low- and Middle-Income Countries (LMICs): A Narrative Review from Prevention to Vaccination Strategy

Author

Sansone Pasquale, Giaccari Luca Gregorio, Aurilio Caterina, Coppolino Francesco, Passavanti Maria Beatrice, Pota Vincenzo, and Pace Maria Caterina

Subjects
COVID-19, low-and middle-income countries (LMICs), infection prevention, triage, vaccine, Medicine
Abstract

The management of the COVID-19 pandemic represents a challenging process, especially for low- and middle-income countries (LMICs) due to the serious economic and health resource problems it generates. In this article, we assess COVID-19 situation in LMICs and outline emerging problems and possible solutions. The prevention and control of COVID-19 would be based on focused tests exploiting those systems (e.g., GeneXpert®) already used in other scenarios. This would be less stressful for the healthcare system in LMICs. Avoiding close contact with people suffering from acute respiratory infections, frequent handwashing, and avoiding unprotected contact with farm or wild animals are recommended infection control interventions. The appropriate use of personal protective equipment (PPE) is required, despite its procurement being especially difficult in LMICs. Patients’ triage should be based on a simple and rapid logarithm to decide who requires isolation and targeted testing for SARS-CoV-2. Being able to estimate which patients will develop severe disease would allow hospitals to better utilize the already limited resources more effectively. In LMICs, laboratories are often in the capital cities; therefore, early diagnosis and isolation become difficult. The number of ICU beds is often insufficient, and the equipment is often old and poorly serviced. LMICs will need access to COVID-19 treatments at minimal prices to ensure that all who need them can be treated. Year-to-date, different vaccines have been approved and are currently available. The main obstacle to accessing them is the limited ability of LMICs to purchase significant quantities of the vaccine.

Published
2021
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26. Plazomicin against Multidrug-Resistant Bacteria: A Scoping Review

Author

Alfieri, Aniello, primary, Di Franco, Sveva, additional, Donatiello, Valerio, additional, Maffei, Vincenzo, additional, Fittipaldi, Ciro, additional, Fiore, Marco, additional, Coppolino, Francesco, additional, Sansone, Pasquale, additional, Pace, Maria Caterina, additional, and Passavanti, Maria Beatrice, additional

Published
2022
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30. Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical trials

Author

Campos, Niklas S., primary, Bluth, Thomas, additional, Hemmes, Sabrine N.T., additional, Librero, Julian, additional, Pozo, Natividad, additional, Ferrando, Carlos, additional, Ball, Lorenzo, additional, Mazzinari, Guido, additional, Pelosi, Paolo, additional, Gama de Abreu, Marcelo, additional, Schultz, Marcus J., additional, Serpa Neto, A., additional, Hemmes, Sabrine NT., additional, Severgnini, Paolo, additional, Hollmann, Markus W., additional, Binnekade, Jan M., additional, Wrigge, Hermann, additional, Canet, Jaume, additional, Hiesmayr, Michael, additional, Schmid, Werner, additional, Tschernko, Edda, additional, Jaber, Samir, additional, Hedenstierna, Göran, additional, Putensen, Christian, additional, Marti, Agnes, additional, Bacuzzi, Alessandro, additional, Brodhun, Alexander, additional, Molin, Alexandre, additional, Merten, Alfred, additional, Parera, Ana, additional, Brunelli, Andrea, additional, Cortegiani, Andrea, additional, Güldner, Andreas, additional, Reske, Andreas W., additional, Gratarola, Angelo, additional, Giarratano, Antonino, additional, Bastin, Bea, additional, Heyse, Bjorn, additional, Mazul-Sunko, Branka, additional, Amantea, Bruno, additional, Barberis, Bruno, additional, Uhlig, Christopher, additional, Marín, Conrado Minguez, additional, Celentano, Cristian, additional, La Bella, Daniela, additional, D’Antini, David, additional, Velghe, David, additional, Sulemanji, Demet, additional, De Robertis, Edoardo, additional, Hartmann, Eric, additional, Montalto, Francesca, additional, Tropea, Francesco, additional, Mills, Gary H., additional, Cinnella, Gilda, additional, Della Rocca, Giorgio, additional, Caggianelli, Girolamo, additional, Pellerano, Giulia, additional, Mollica, Giuseppina, additional, Bugedo, Guillermo, additional, Mulier, Jan-Paul, additional, Vandenbrande, Jeroen, additional, Geib, Johann, additional, Yaqub, Jonathan, additional, Florez, Jorge, additional, Mayoral, Juan F., additional, Sprung, Juraj, additional, Van Limmen, Jurgen, additional, Bos, Lieuwe DJ., additional, de Baerdemaeker, Luc, additional, Jamaer, Luc, additional, Spagnolo, Luigi, additional, Strys, Lydia, additional, Gil, Manuel Granell, additional, Vidal Melo, Marcos F., additional, Unzueta, Maria Carmen, additional, Moral, Maria Victoria, additional, Ferner, Marion, additional, Weiss, Martin, additional, Vanoni, Massimo, additional, Schaefer, Maximilian S., additional, Prieto, Mercè, additional, Grio, Michele, additional, Spieth, Peter Markus, additional, Simon, Philipp, additional, Bodger, Phoebe, additional, Sierra, Pilar, additional, Laufenberg-Feldmann, Rita, additional, Rusca, Roberta, additional, Proietti, Rodolfo, additional, Raineri, Santi Maurizio, additional, Caroleo, Santo, additional, Sabaté, Sergi, additional, De Hert, Stefan, additional, Pezzato, Stefano, additional, Treschan, Tanja A., additional, Goranovic, Tatjana, additional, Koch, Thea, additional, Kiss, Thomas, additional, Perilli, Valter, additional, Cegarra, Virginia, additional, Belda, Javier, additional, Soro, Marina, additional, Unzueta, Carmen, additional, Suarez-Sipmann, Fernando, additional, Librero, Julián, additional, Llombart, Alicia, additional, Rovira, Lucas, additional, Granell, Manuel, additional, Aldecoa, César, additional, Diaz-Cambronero, Oscar, additional, Balust, Jaume, additional, Garutti, Ignacio, additional, Gonzalez, Rafael, additional, Gallego, Lucia, additional, Garcia del Valle, Santiago, additional, Redondo, Javier, additional, Pestaña, David, additional, Rodríguez, Aurelio, additional, García, Javier, additional, Matta, Manuel de la, additional, Ibáñez, Maite, additional, Barrios, Francisco, additional, Hernández, Samuel, additional, Torres, Vicente, additional, Peiró, Salvador, additional, Villena, Abigail, additional, Carramiñana, Albert, additional, Gallego-Casilda, Alberto, additional, Duca, Alejandro, additional, Alcón, Amalia, additional, Miñana, Amanda, additional, Asensio, Ana, additional, Colás, Ana, additional, Galve, Ana Isabel, additional, Izquierdo, Ana, additional, Jurado, Ana, additional, Pérez, Ana María, additional, Mugarra, Ana, additional, Gutierrez, Andrea, additional, De Miguel, Ángeles, additional, Lozano, Angels, additional, Katime, Antonio, additional, Romero, Antonio, additional, Garrigues, Beatriz, additional, Ayas, Begoña, additional, Arocas, Blanca, additional, Delgado, Carlos, additional, Fernández, Carmen, additional, Romero, Carolina, additional, Gallego, Clara, additional, Garcés, Cristina, additional, Lisbona, Cristina, additional, Parrilla, Cristina, additional, López-Herrera, Daniel, additional, González, Domingo, additional, Llamazares, Eduardo, additional, Del Rio, Elena, additional, Lozano, Elena, additional, Pastor, Ernesto, additional, Chamorro, Estefanía, additional, Gracia, Estefanía, additional, Sánchez, Ester, additional, Romero, Esther, additional, Díez, Fernando, additional, Serralta, Ferran, additional, Daviu, Francisco, additional, Sandín, Francisco, additional, Aguilar, Gerardo, additional, Tusman, Gerardo, additional, Azparren, Gonzalo, additional, Martínez-Pallí, Graciela, additional, Benítez, Inmaculada, additional, Hernandéz, Inmaculada, additional, India, Inmaculada, additional, León, Irene, additional, Fuentes, Isabel, additional, Ruiz, Isabel, additional, Puig, Jaume, additional, Román, Javie Ignacio, additional, Acosta, Jesús, additional, Rico-Feijoo, Jesús, additional, Olmedo, Jonathan, additional, Carbonell, Jose A., additional, Alonso, Jose M., additional, Pérez, Jose María, additional, Marcos, Jose Miguel, additional, Navarro, Jose, additional, Valdivia, Jose, additional, Carrizo, Juan, additional, Piqueras, Laura, additional, Soriano, Laura, additional, Vaquero, Laura, additional, Miguel, Lisset, additional, Muñoz, Lorena, additional, Valencia, Lucia, additional, Olmedilla, Luis, additional, Etulain, Mᵃ Justina, additional, Tisner, Manuel, additional, Barrio, María, additional, Alonso, María Dolores, additional, García, María, additional, Hernández, María J., additional, Alberola, María José, additional, Parra, María, additional, Argente, María Pilar, additional, Vila, María, additional, De Fez, Mario, additional, Agilaga, Marta, additional, Gine, Marta, additional, Ayuso, Mercedes, additional, García, Mercedes, additional, Bejarano, Natalia, additional, Peña, Natalia, additional, Ojeda, Nazario, additional, Martínez, Nilda, additional, García, Nuria, additional, Padrón, Oto, additional, García, Pablo, additional, Valls, Paola, additional, Cruz, Patricia, additional, Piñeiro, Patricia, additional, Charco, Pedro, additional, Anaya, Rafael, additional, López, Ramiro, additional, Rodríguez, Rayco, additional, Martínez, Rocío, additional, Pujol, Roger, additional, Dosdá, Rosa, additional, Lardies, Rosa, additional, Díaz, Ruben, additional, Villazala, Rubén, additional, Zapatero, Sara, additional, Cabrera, Sergio, additional, Sánchez, Sergio, additional, Martin, Silvia, additional, Diaz, Suzana, additional, Franco, Tania, additional, Moreno, Tania, additional, Socorro, Tania, additional, Gilabert, Vicente, additional, Balandrón, Victor, additional, Moral, Victoria, additional, Cegarra, Virgina, additional, Varón, Viviana, additional, Abelha, Fernando, additional, Abitağaoğlu, Sühayla, additional, Achilles, Marc, additional, Adebesin, Afeez, additional, Adriaensens, Ine, additional, Ahene, Charles, additional, Akbar, Fatima, additional, Al Harbi, Mohammed, additional, Al Khoury al Kallab, Rita, additional, Albanel, Xavier, additional, Aldenkortt, Florence, additional, Saleh Alfouzan, Rawan Abdullah, additional, Alruqaie, Reef, additional, Altermatt, Fernando, additional, Luís de Castro Araujo, Bruno, additional, Arbesú, Genaro, additional, Artsi, Hanna, additional, Aurilio, Caterina, additional, Ayanoglu, Omer Hilmi, additional, Baig, Harris, additional, Baird, Yolanda, additional, Balonov, Konstantin, additional, Banks, Samantha, additional, Bao, Xiaodong, additional, Baumgartner, Mélanie, additional, Tortosa, Isabel Belda, additional, Bergamaschi, Alice, additional, Bergmann, Lars, additional, Bigatello, Luca, additional, Pérez, Elena Biosca, additional, Birr, Katja, additional, Bojaxhi, Elird, additional, Bonenti, Chiara, additional, Bonney, Iwona, additional, Bos, Elke M.E., additional, Bowman, Sara, additional, Braz, Leandro Gobbo, additional, Brugnoni, Elisa, additional, Brull, Sorin J., additional, Brunetti, Iole, additional, Bruni, Andrea, additional, Buenvenida, Shonie L., additional, Busch, Cornelius Johannes, additional, Camerini, Giovanni, additional, Capatti, Beatrice, additional, Carmona, Javiera, additional, Carungcong, Jaime, additional, Carvalho, Marta, additional, Cattan, Anat, additional, Cavaleiro, Carla, additional, Chiumello, Davide, additional, Ciardo, Stefano, additional, Coburn, Mark, additional, Colella, Umberto, additional, Contreras, Victor, additional, Dincer, Pelin Corman, additional, Cotter, Elizabeth, additional, Crovetto, Marcia, additional, Darrah, William, additional, Davies, Simon, additional, Del Cojo Peces, Enrique, additional, Delphin, Ellise, additional, Diaper, John, additional, Junior, Paulo do Nascimento, additional, Donatiello, Valerio, additional, Dong, Jing, additional, Dourado, Maria do Socorro, additional, Dullenkopf, Alexander, additional, Ebner, Felix, additional, Elgendy, Hamed, additional, Ellenberger, Christoph, additional, Arı, Dilek Erdoğan, additional, Ermert, Thomas, additional, Farah, Fadi, additional, Fernandez-Bustamante, Ana, additional, Ferreira, Cristina, additional, Fiore, Marco, additional, Fonte, Ana, additional, Palahí, Christina Fortià, additional, Galimberti, Andrea, additional, Garofano, Najia, additional, Giaccari, Luca Gregorio, additional, Gilsanz, Fernando, additional, Girrbach, Felix, additional, Gobbi, Luca, additional, Godfried, Marc Bernard, additional, Goettel, Nicolai, additional, Goldstein, Peter A., additional, Goren, Or, additional, Gorlin, Andrew, additional, Graterol, Juan, additional, Guyon, Pierre, additional, Haire, Kevin, additional, Harou, Philippe, additional, Helf, Antonia, additional, Hempel, Gunther, additional, Hernández Cádiz, María José, additional, Heyse, Björn, additional, Huercio, Ivan, additional, Ilievska, Jasmina, additional, Jakus, Lien, additional, Jeganath, Vijay, additional, Jelting, Yvonne, additional, Jung, Minoa, additional, Kabon, Barbara, additional, Kacha, Aalok, additional, Ilić, Maja Karaman, additional, Karuppiah, Arunthevaraja, additional, Kavas, Ayse Duygu, additional, Barcelos, Gleicy Keli, additional, Kellogg, Todd A., additional, Kemper, Johann, additional, Kerbrat, Romain, additional, Khodr, Suraya, additional, Kienbaum, Peter, additional, Kir, Bunyamin, additional, Kivrak, Selin, additional, Klarić, Vlasta, additional, Köksal, Ceren, additional, Kowark, Ana, additional, Kranke, Peter, additional, Kuvaki, Bahar, additional, Kuzmanovska, Biljana, additional, Laffey, John, additional, Lange, Mirko, additional, Freitas de Lemos, Marília, additional, Licker, Marc-Joseph, additional, López-Baamonde, Manuel, additional, López-Hernández, Antonio, additional, Lopez-Martinez, Mercedes, additional, Luise, Stéphane, additional, MacGregor, Mark, additional, Magalhães, Danielle, additional, Maillard, Julien, additional, Malerbi, Patrizia, additional, Manimekalai, Natesan, additional, Margarson, Michael, additional, Markstaller, Klaus, additional, Martin, Archer K., additional, Martin, David P., additional, Martin, Yvette N., additional, Martínez-Ocon, Julia, additional, Martin-Loeches, Ignacio, additional, Maseda, Emilio, additional, Matot, Idit, additional, McAuliffe, Niamh, additional, McKenzie, Travis J., additional, Medina, Paulina, additional, Meersch, Melanie, additional, Menzen, Angelika, additional, Mertens, Els, additional, Meurer, Bernd, additional, Meyer-Treschan, Tanja, additional, Miao, Changhong, additional, Micalizzi, Camilla, additional, Milić, Morena, additional, Pinheiro Módolo, Norma Sueli, additional, Moine, Pierre, additional, Mölders, Patrick, additional, Montero-Feijoo, Ana, additional, Moret, Enrique, additional, Muller, Markus K., additional, Murphy, Zoe, additional, Nalwaya, Pramod, additional, Naumovski, Filip, additional, Navalesi, Paolo, additional, Navarro e Lima, Lais Helena, additional, Adam, Višnja Nesek, additional, Neumann, Claudia, additional, Newell, Christopher, additional, Nisnevitch, Zoulfira, additional, Nizamuddin, Junaid, additional, Novazzi, Cecilia, additional, O'Connor, Michael, additional, Oprea, Günther, additional, Sungur, Mukadder Orhan, additional, Özbilgin, Şule, additional, Pace, Maria Caterina, additional, Pacheco, Marcos, additional, Packianathaswamy, Balaji, additional, Gonzalez, Estefania Palma, additional, Papaspyros, Fotios, additional, Paredes, Sebastián, additional, Passavanti, Maria Beatrice, additional, Pedemonte, Juan Cristobal, additional, Peremin, Sanja, additional, Philipsenburg, Christoph, additional, Pinho, Daniela, additional, Pinho, Silvia, additional, Posthuma, Linda M., additional, Pota, Vincenzo, additional, Preckel, Benedikt, additional, Priani, Paolo, additional, Rached, Mohamed Aymen, additional, Radoeshki, Aleksandar, additional, Ragazzi, Riccardo, additional, Rajamanickam, Tamilselvan, additional, Rajamohan, Arthi, additional, Ramakrishna, Harish, additional, Rangarajan, Desikan, additional, Reiterer, Christian, additional, Renew, J. Ross, additional, Reynaud, Thomas, additional, Rhys, Rhidian, additional, Rivas, Eva, additional, Robitzky, Luisa, additional, Rossaint, Rolf, additional, Rubulotta, Francesca, additional, Machado, Humberto S., additional, Nunes, Catarina S., additional, Sabbatini, Giovanni, additional, Samuels, Jon D., additional, Sanahuja, Josep Martí, additional, Sansone, Pasquale, additional, Santos, Alice, additional, Sayedalahl, Mohamed, additional, Scharffenberg, Martin, additional, Schiffer, Eduardo, additional, Schliewe, Nadja, additional, Schorer, Raoul, additional, Schumann, Roman, additional, Selmo, Gabriele, additional, Sendra, Mar, additional, Senturk, Mert, additional, Shaw, Kate, additional, Shosholcheva, Mirjana, additional, Sibai, Abdulrazak, additional, Simonassi, Francesca, additional, Sinno, Claudia, additional, Sivrikoz, Nukhet, additional, Skandalou, Vasiliki, additional, Smith, Neil, additional, Soares, Maria, additional, Artiles, Tania Socorro, additional, Castro, Diogo Sousa, additional, Sousa, Miguel, additional, Spadaro, Savino, additional, Stamatakis, Emmanouil, additional, Steiner, Luzius A., additional, Stevenazzi, Andrea, additional, Suarez-de-la-Rica, Alejandro, additional, Suppan, Mélanie, additional, Teichmann, Robert, additional, Tena Guerrero, José Maria, additional, Thiel, Bram, additional, Tolós, Raquel, additional, Altun, Gulbin Tore, additional, Tucci, Michelle, additional, Turnbull, Zachary A., additional, Turudić, Žana, additional, Unterberg, Matthias, additional, Van Nieuwenhove, Yves, additional, Van Waesberghe, Julia, additional, Vidal Melo, Marcos Francisco, additional, Vitković, Bibiana, additional, Vivona, Luigi, additional, Vizcaychipi, Marcela, additional, Volta, Carlo Alberto, additional, Weber, Anne, additional, Weingarten, Toby N., additional, Wittenstein, Jakob, additional, Wyffels, Piet, additional, Yagüe, Julio, additional, Yates, David, additional, Yavru, Ayşen, additional, Zac, Lilach, additional, and Zhong, Jing, additional

Published
2022
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32. Mechanisms of Action of Carbapenem Resistance

Author

Aurilio, Caterina, primary, Sansone, Pasquale, additional, Barbarisi, Manlio, additional, Pota, Vincenzo, additional, Giaccari, Luca Gregorio, additional, Coppolino, Francesco, additional, Barbarisi, Alfonso, additional, Passavanti, Maria Beatrice, additional, and Pace, Maria Caterina, additional

Published
2022
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33. Use of colistin in adult patients: a cross-sectional study

Author

Giacobbe, Daniele Roberto, Saffioti, Carolina, Losito, Angela Raffaella, Rinaldi, Matteo, Aurilio, Caterina, Bolla, Cesare, Boni, Silvia, Borgia, Guglielmo, Carannante, Novella, Cassola, Giovanni, Ceccarelli, Giancarlo, Corcione, Silvia, Gasperina, Daniela Dalla, De Rosa, Francesco Giuseppe, Dentone, Chiara, Di Bella, Stefano, Di Lauria, Nicoletta, Feasi, Marcello, Fiore, Marco, Fossati, Sara, Franceschini, Erica, Gori, Andrea, Granata, Guido, Grignolo, Sara, Grossi, Paolo Antonio, Guadagnino, Giuliana, Lagi, Filippo, Maraolo, Alberto Enrico, Marinò, Valeria, Mazzitelli, Maria, Mularoni, Alessandra, Oliva, Alessandra, Pace, Maria Caterina, Parisini, Andrea, Patti, Francesca, Petrosillo, Nicola, Pota, Vincenzo, Raffaelli, Francesca, Rossi, Marianna, Santoro, Antonella, Tascini, Carlo, Torti, Carlo, Trecarichi, Enrico Maria, Venditti, Mario, Viale, Pierluigi, Signori, Alessio, Del Bono, Valerio, Giannella, Maddalena, Mikulska, Malgorzata, Tumbarello, Mario, Viscoli, Claudio, Passavanti, Maria Beatrice, Rogati, C, Sansone, Pasquale, Sarteschi, G, Roberto Giacobbe, Daniele, Saffioti1, Carolina, Raffaella Losito, Angela, Rinaldi, Matteo, Aurilio, Caterina, Bolla, Cesare, Boni, Silvia, Borgia, Guglielmo, Carannante, Novella, Cassola, Giovanni, Ceccarelli, Giancarlo, Corcione, Silvia, Dalla Gasperina, Daniela, Giuseppe De Rosa, Francesco, Dentone, Chiara, DI BELLA, Stefano, Di Lauria, Nicoletta, Feasi, Marcello, Fiore, Marco, Fossati, Sara, Franceschini, Erica, Gori, Andrea, Granata, Guido, Grignolo, Sara, Antonio Grossi, Paolo, Guadagnino, Giuliana, Lagi, Filippo, Enrico Maraolo, Alberto, Marinò, Valeria, Mazzitelli, Maria, Mularoni, Alessandra, Oliva, Alessandra, Caterina Pace, Maria, Parisini, Andrea, Patti, Francesca, Petrosillo, Nicola, Pota, Vincenzo, Raffaelli, Francesca, Rossi, Marianna, Santoro, Antonella, Tascini, Carlo, Torti, Carlo, Maria Trecarichi, Enrico, Venditti, Mario, Viale, Pierluigi, Signori, Alessio, Bassetti, Matteo, Del Bono, Valerio, Giannella, Maddalena, Mikulska, Malgorzata, Tumbarello, Mario, Viscoli, Claudio, Giacobbe, Daniele Roberto, Saffioti, Carolina, Losito, Angela Raffaella, Gasperina, Daniela Dalla, De Rosa, Francesco Giuseppe, Di Bella, Stefano, Grossi, Paolo Antonio, Maraolo, Alberto Enrico, Pace, Maria Caterina, Trecarichi, Enrico Maria, Passavanti, Maria Beatrice, Rogati, C, Sansone, Pasquale, Sarteschi, G, Giacobbe D.R., Saffioti C., Losito A.R., Rinaldi M., Aurilio C., Bolla C., Boni S., Borgia G., Carannante N., Cassola G., Ceccarelli G., Corcione S., Dalla Gasperina D., De Rosa F.G., Dentone C., Di Bella S., Di Lauria N., Feasi M., Fiore M., Fossati S., Franceschini E., Gori A., Granata G., Grignolo S., Grossi P.A., Guadagnino G., Lagi F., Maraolo A.E., Marino V., Mazzitelli M., Mularoni A., Oliva A., Pace M.C., Parisini A., Patti F., Petrosillo N., Pota V., Raffaelli F., Rossi M., Santoro A., Tascini C., Torti C., Trecarichi E.M., Venditti M., Viale P., Signori A., Bassetti M., Del Bono V., Giannella M., Mikulska M., Tumbarello M., and Viscoli C.

Subjects
0301 basic medicine, Male, Endemic Diseases, Drug Resistance, Carbapenem-resistant enterobacteriaceae, Pseudomona, 0302 clinical medicine, Interquartile range, Levofloxacin, Drug Resistance, Multiple, Bacterial, Klebsiella, polycyclic compounds, Acinetobacter, Antimicrobial resistance, Colistimethate, Colistin, Pseudomonas, Administration, Intravenous, Aged, Anti-Bacterial Agents, Cross-Sectional Studies, Drug Prescriptions, Drug Therapy, Combination, Female, Gram-Negative Bacterial Infections, Humans, Italy, Middle Aged, Respiratory Tract Infections, Sepsis, Immunology and Allergy, 030212 general & internal medicine, colistin, colistimethate, Bacterial, QR1-502, Administration, Combination, lipids (amino acids, peptides, and proteins), antimicrobial resistance, Intravenous, Multiple, medicine.drug, Microbiology (medical), medicine.medical_specialty, Cefepime, 030106 microbiology, Immunology, Microbiology, Loading dose, 03 medical and health sciences, Drug Therapy, Internal medicine, Lower respiratory tract infection, medicine, business.industry, biochemical phenomena, metabolism, and nutrition, medicine.disease, business
Abstract

Objectives The aim of this study was to assess colistin use in a country endemic for multidrug-resistant Gram-negative bacteria (MDR-GNB). Methods Colistin prescription patterns were evaluated in 22 Italian centres. Factors associated with use of colistin in combination with other anti-MDR-GNB agents were also assessed. Results A total of 221 adults receiving colistin were included in the study. Their median age was 64 years (interquartile range 52–73 years) and 134 (61%) were male. Colistin was mostly administered intravenously (203/221; 92%) and mainly for targeted therapy (168/221; 76%). The most frequent indications for colistin therapy were bloodstream infection and lower respiratory tract infection. Intravenous colistin was administered in combination with at least another anti-MDR-GNB agent in 80% of cases (163/203). A loading dose of 9 MU of colistimethate was administered in 79% of patients receiving i.v. colistin and adequate maintenance doses in 85%. In multivariable analysis, empirical therapy [odds ratio (OR) = 3.25, 95% confidence interval (CI) 1.24–8.53;P = 0.017] and targeted therapy for carbapenem-resistant Enterobacterales infection (OR = 4.76, 95% CI 1.69–13.43; P = 0.003) were associated with use of colistin in combination with other agents, whilst chronic renal failure (OR = 0.39, 95% CI 0.17–0.88; P = 0.024) was associated with use of colistin monotherapy. Conclusion Colistin remains an important option for severe MDR-GNB infections when other treatments are not available. Despite inherent difficulties in optimising its use owing to peculiar pharmacokinetic/pharmacodynamic characteristics, colistin was mostly used appropriately in a country endemic for MDR-GNB.

Published
2020

34. Blood Stream Infections from MDR Bacteria

Author

Di Franco, Sveva, primary, Alfieri, Aniello, additional, Pace, Maria Caterina, additional, Sansone, Pasquale, additional, Pota, Vincenzo, additional, Fittipaldi, Ciro, additional, Fiore, Marco, additional, and Passavanti, Maria Beatrice, additional

Published
2021
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40. What is the role of locoregional anesthesia in breast surgery? A systematic literature review focused on pain intensity, opioid consumption, adverse events, and patient satisfaction

Author

Sansone, Pasquale, primary, Giaccari, Luca Gregorio, additional, Faenza, Mario, additional, Costanzo, Pasquale Di, additional, Izzo, Sara, additional, Aurilio, Caterina, additional, Coppolino, Francesco, additional, Passavanti, Maria Beatrice, additional, Pota, Vincenzo, additional, and Pace, Maria Caterina, additional

Published
2020
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42. Current status of COVID-19 treatment: An opinion review

Author

Franco, Sveva Di, primary, Alfieri, Aniello, additional, Petrou, Stephen, additional, Damiani, Giovanni, additional, Passavanti, Maria Beatrice, additional, Pace, Maria Caterina, additional, Leone, Sebastiano, additional, and Fiore, Marco, additional

Published
2020
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47. First Italian outbreak of VIM-producingSerratia marcescensin an adult polyvalent intensive care unit, August-October 2018: A case report and literature review

Author

Iovene, Maria Rosaria, primary, Pota, Vincenzo, additional, Galdiero, Massimiliano, additional, Corvino, Giusy, additional, Lella, Federica Maria Di, additional, Stelitano, Debora, additional, Passavanti, Maria Beatrice, additional, Pace, Maria Caterina, additional, Alfieri, Aniello, additional, Franco, Sveva Di, additional, Aurilio, Caterina, additional, Sansone, Pasquale, additional, Niyas, Vettakkara Kandy Muhammed, additional, and Fiore, Marco, additional

Published
2019
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49. CGRP and Visceral Pain: The Role of Sex Hormones in In Vitro Experiment

Author

Pota, V., Quagliariello, V., Armenia, E., AURILIO, Caterina, PASSAVANTI, Maria Beatrice, SANSONE, Pasquale, Iannotti, M., CATAURO, Michelina, Coaccioli, S., BARBARISI, Manlio, PACE, Maria Caterina, Pota, V., Quagliariello, V., Armenia, E., Aurilio, Caterina, Passavanti, Maria Beatrice, Sansone, Pasquale, Iannotti, M., Catauro, Michelina, Coaccioli, S., Barbarisi, Manlio, and Pace, Maria Caterina

Subjects
CGRP, GENDER, VISCERAL PAIN
Abstract

A large number of studies have showed that women reported feeling pain more acutely than men. In support of this hypothesis, many research groups proved that in different animals model of pain the sex hormones regulate the somatic and visceral sensitivity to different noxious stimuli. Therefore, in this study, we went to evaluate if estrogen hormones by regulating the CGRP levels are implicated during the visceral pain transmission. Toward this aim, we have investigated the effect of 17β-estradiol in regulating the synthesis and release of CGRP, as well as the expression levels of the opioid receptor of type K. In order to gain information about the potential effects of 17β-estradiol on K-opioid receptor expression and activity, we have cultured F11 cells. Our results revealed that, when F11 cells were short-term exposed (30 min) to 17β-estradiol, the expression of the opioid K receptor was not significantly modified. We carried out enzyme immunoassay analysis to evaluate the potential effects of short-term exposure to 17-estradiol (30 min) on the release of CGRP in F11 cells. The results obtained showed that 17β-estradiol at the dose of 100 nM is able to induce the release of CGRP from F11 cells; whereas, a higher dose of 17β-estradiol (200 nM) did not produce significant effects when compared to control. In conclusion, all these findings suggest that the 17β-estradiol-regulated release of CGRP could at least in part provide a rational explanation for the difference of gender in the visceral pain sensitivity. J. Cell. Biochem. 118: 510–517, 2017. © 2016 Wiley Periodicals, Inc. A large number of studies have showed that women reported feeling pain more acutely than men. In support of this hypothesis, many research groups proved that in different animals model of pain the sex hormones regulate the somatic and visceral sensitivity to different noxious stimuli. Therefore, in this study, we went to evaluate if estrogen hormones by regulating the CGRP levels are implicated during the visceral pain transmission. Toward this aim, we have investigated the effect of 17β-estradiol in regulating the synthesis and release of CGRP, as well as the expression levels of the opioid receptor of type K. In order to gain information about the potential effects of 17β-estradiol on K-opioid receptor expression and activity, we have cultured F11 cells. Our results revealed that, when F11 cells were short-term exposed (30 min) to 17β-estradiol, the expression of the opioid K receptor was not significantly modified. We carried out enzyme immunoassay analysis to evaluate the potential effects of short-term exposure to 17-estradiol (30 min) on the release of CGRP in F11 cells. The results obtained showed that 17β-estradiol at the dose of 100 nM is able to induce the release of CGRP from F11 cells; whereas, a higher dose of 17β-estradiol (200 nM) did not produce significant effects when compared to control. In conclusion, all these findings suggest that the 17β-estradiol-regulated release of CGRP could at least in part provide a rational explanation for the difference of gender in the visceral pain sensitivity. J. Cell. Biochem. 118: 510–517, 2017. © 2016 Wiley Periodicals, Inc.

Published
2017

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