Search

Your search keyword '"PASQUALETTI M"' showing total 286 results
Start Over Author "PASQUALETTI M"
286 results on '"PASQUALETTI M"'

4. Challenges, dilemmas and success criteria of recycling coal mining landscapes

Author

Frantál Bohumil, Pasqualetti Martin J., and Brisudová Lucia

Subjects
energy landscape, recycling, post-mining land use, restoration, reclamation, regeneration, sustainability, czech republic, Geography (General), G1-922
Abstract

As our crowded and warming world continues moving away from fossil fuels such as coal, we are increasingly attempting to transform the landscapes damaged by mining into beneficial, appealing and valuable new uses. The post-mining transformation involves many dilemmas, often arouses land use conflicts and can reproduce environmental injustices. In the background of conflicts are diverging preferences for post-mining land uses from the perspective of various stakeholders. This paper examines key issues and dilemmas in post-mining transformation, including terminological inconsistencies, technical reclamation versus natural succession, heritage preservation choices, authenticity concerns, and success criteria issues. The underlying question we ask is: What is the future use of the coal energy landscape; that is, what should or could come next? To address this question, we provide a comprehensive literature review and an analysis of a sample of 28 case studies of good practice projects of reclamation or regeneration (i. e., recycling) coal mining landscapes from the Czech Republic. This study is distinctive in its comprehensive scope, analyzing a diverse range of recycling projects from surface mining landscapes to urban post-mining brownfields, with extensive analysis and findings. While the criteria of transparency and legitimacy of projects are essential for applying the principles of just transition, the criteria of efficiency and sustainability prove to be key measures of success according to which differences between projects appear in the longer term. The efficiency and sustainability are significantly associated with the multifunctionality of recycled landscapes and places and seasonality of their use.

Published
2024
Full Text
View/download PDF

7. Persistence of enterobacteriaceae drawn into a marine saltern (Saline di Tarquinia, Italy) from the adjacent coastal zone

Author

Gorrasi, S, Pasqualetti, M, Franzetti, A, Gonzalez-Martinez, A, Gonzalez-Lopez, J, Munoz-Palazon, B, Fenice, M, Gorrasi S., Pasqualetti M., Franzetti A., Gonzalez-Martinez A., Gonzalez-Lopez J., Munoz-Palazon B., Fenice M., Gorrasi, S, Pasqualetti, M, Franzetti, A, Gonzalez-Martinez, A, Gonzalez-Lopez, J, Munoz-Palazon, B, Fenice, M, Gorrasi S., Pasqualetti M., Franzetti A., Gonzalez-Martinez A., Gonzalez-Lopez J., Munoz-Palazon B., and Fenice M.

Abstract

Enterobacteriaceae is present in various niches worldwide (i.e., the gastrointestinal tracts of animals, clinical specimens, and diverse environments) and hosts some well-known pathogens (i.e., salmonellas, shigellas and pathogenic coliforms). No investigation has focused on its occurrence in marine salterns, and it is not clear if these hypersaline environments could be a reservoir for these bacteria including some potentially harmful members. In this study, a two-year metabarcoding survey was carried out on samples collected from different ponds of the “Saline di Tarquinia” salterns and the nearby coastal waters. Enterobacteriaceae was recorded almost constantly in the seawaters feeding the saltern. Its abundance was generally higher in the sea than in the ponds, probably due to the higher anthropic impact. The same trend was evidenced for the key genus (Escherichia/Shigella) and OTU (OTU 5) of the Enterobacteriaceae community. Various parameters affected taxon/OTU abundance: Enterobacteriaceae, Escherichia/Shigella and OTU5 decreased with increasing salinity and rains; moreover, Escherichia/Shigella and OTU 5 were higher in autumn than in spring. Although Enterobacteriaceae did not seem to find the most favourable conditions for a high-abundance persistence in the saltern environment, it did not disappear. These observations suggested this environment as a potential reservoir for bacteria with possible important health implications.

Published
2021

9. The Relationship between ACE, ACTN3 and MCT1 Genetic Polymorphisms and Athletic Performance in Elite Rugby Union Players: A Preliminary Study

Author

Pasqualetti, Massimo, Onori, Maria Elisabetta, Canu, Giulia, Moretti, G, Minucci, Angelo, Baroni, Silvia, Mordente, Alvaro, Urbani, Andrea, Galvani, Christel, Pasqualetti M, Onori ME, Canu G, Moretti G, Minucci A, Baroni S (ORCID:0000-0002-3410-2617), Mordente A (ORCID:0000-0003-3260-9796), Urbani A (ORCID:0000-0001-9168-3174), Galvani C (ORCID:0000-0002-0126-6033), Pasqualetti, Massimo, Onori, Maria Elisabetta, Canu, Giulia, Moretti, G, Minucci, Angelo, Baroni, Silvia, Mordente, Alvaro, Urbani, Andrea, Galvani, Christel, Pasqualetti M, Onori ME, Canu G, Moretti G, Minucci A, Baroni S (ORCID:0000-0002-3410-2617), Mordente A (ORCID:0000-0003-3260-9796), Urbani A (ORCID:0000-0001-9168-3174), and Galvani C (ORCID:0000-0002-0126-6033)

Abstract

Athletic performance is influenced by many factors such as the environment, diet, training and endurance or speed in physical effort and by genetic predisposition. Just a few studies have analyzed the impact of genotypes on physical performance in rugby. The aim of this study was to verify the modulation of genetic influence on rugby-specific physical performance. Twenty-seven elite rugby union players were involved in the study during the in-season phase. Molecular genotyping was performed for: angiotensin-converting enzyme (ACE rs4646994), alfa-actinin-3 (ACTN3 rs1815739) and monocarboxylate transporter 1 (MCT1 rs1049434) and their variants. Lean mass index (from skinfolds), lower-limb explosive power (countermovement jump), agility (505), speed (20 m), maximal aerobic power (Yo-yo intermittent recovery test level 1) and repeated sprint ability (12 × 20 m) were evaluated. In our rugby union players ACE and ACTN3 variants did not show any influence on athletic performance. MCT1 analysis showed that TT-variant players had the highest peak vertical power (p = 0.037) while the ones with the AA genotype were the fastest in both agility and sprint tests (p = 0.006 and p = 0.012, respectively). Considering the T-dominant model, the AA genotype remains the fastest in both tests (agility: p = 0.013, speed: p = 0.017). Only the MCT1 rs1049434 A allele seems to be advantageous for elite rugby union players, particularly when power and speed are required

Published
2022

12. The continued need for animals to advance brain research

Author

Homberg, J.R., Adan, R.A., Alenina, N., Asiminas, A., Bader, M., Beckers, T., Begg, D.P., Blokland, A., Burger, M.E., Dijk, G. Van, Eisel, U.L., Elgersma, Y., Englitz, B., Fernandez-Ruiz, A., Fitzsimons, C.P., Dam, A.M.W. van, Gass, P., Grandjean, J., Havekes, R., Henckens, M.J.A.G., Herden, C., Hut, R.A., Jarrett, W., Jeffrey, K., Jezova, D., Kalsbeek, A., Kamermans, M., Kas, M.J., Nadif Kasri, N., Kiliaan, A.J., Kolk, S.M., Korosi, A., Korte, S.M., Kozicz, T., Kushner, S.A., Leech, K., Lesch, K.P., Lesscher, H., Lucassen, P.J., Luthi, A., Ma, L., Mallien, A.S., Meerlo, P., Mejias, J.F., Meye, F.J., Mitchell, A.S., Mul, J.D., Olcese, U., González, A.O., Olivier, J.D., Pasqualetti, M., Pennartz, C.M.A., Popik, P., Prickaerts, J., Prida, L.M. de la, Ribeiro, S., Roozendaal, B., Rossato, J.I., Salari, A.A., Schoemaker, R.G., Smit, A.B., Vanderschuren, L., Takeuchi, T., Veen, R. van der, Smidt, M.P., Vyazovskiy, V.V., Wiesmann, M., Wierenga, C.J., Williams, B., Willuhn, I., Wöhr, M., Wolvekamp, M., Zee, E.A. van der, Genzel, L., Homberg, J.R., Adan, R.A., Alenina, N., Asiminas, A., Bader, M., Beckers, T., Begg, D.P., Blokland, A., Burger, M.E., Dijk, G. Van, Eisel, U.L., Elgersma, Y., Englitz, B., Fernandez-Ruiz, A., Fitzsimons, C.P., Dam, A.M.W. van, Gass, P., Grandjean, J., Havekes, R., Henckens, M.J.A.G., Herden, C., Hut, R.A., Jarrett, W., Jeffrey, K., Jezova, D., Kalsbeek, A., Kamermans, M., Kas, M.J., Nadif Kasri, N., Kiliaan, A.J., Kolk, S.M., Korosi, A., Korte, S.M., Kozicz, T., Kushner, S.A., Leech, K., Lesch, K.P., Lesscher, H., Lucassen, P.J., Luthi, A., Ma, L., Mallien, A.S., Meerlo, P., Mejias, J.F., Meye, F.J., Mitchell, A.S., Mul, J.D., Olcese, U., González, A.O., Olivier, J.D., Pasqualetti, M., Pennartz, C.M.A., Popik, P., Prickaerts, J., Prida, L.M. de la, Ribeiro, S., Roozendaal, B., Rossato, J.I., Salari, A.A., Schoemaker, R.G., Smit, A.B., Vanderschuren, L., Takeuchi, T., Veen, R. van der, Smidt, M.P., Vyazovskiy, V.V., Wiesmann, M., Wierenga, C.J., Williams, B., Willuhn, I., Wöhr, M., Wolvekamp, M., Zee, E.A. van der, and Genzel, L.

Abstract

Item does not contain fulltext, Policymakers aim to move toward animal-free alternatives for scientific research and have introduced very strict regulations for animal research. We argue that, for neuroscience research, until viable and translational alternatives become available and the value of these alternatives has been proven, the use of animals should not be compromised.

Published
2021

15. Vibrio communities along a salinity gradient within a marine saltern hypersaline environment (Saline di Tarquinia, Italy)

Author

Gorrasi, S, Pasqualetti, M, Franzetti, A, Pittino, F, Fenice, M, Gorrasi, S, Pasqualetti, M, Franzetti, A, Pittino, F, and Fenice, M

Abstract

Vibrio species are ubiquitous in a number of different aquatic environments and promptly adapting to environmental changes due to high genome plasticity. The presence of these bacteria in marine salterns, in relation to a salinity gradient has been not investigated yet. Moreover, it is not clear if these hypersaline environments could represent a reservoir for Vibrio spp. This work investigated, through a metagenetic approach, the distribution of Vibrio (over 2 years) in different ponds along the salinity gradient within the ‘Saline di Tarquinia’ salterns, considering also the adjacent coastal waters and an isolated brine storage basin (BSB). Vibrio occurrence was higher in the sea than in the ponds and BSB, where it usually represented a rare taxon (abundance <1%). In the sea, it showed abundances in-between 1%–2.6% in 8 months out of 24. Four OTUs were assigned to the Vibrio genus; except for one that was more abundant in BSB, the others were much higher in the sea. Redundancy analysis (RDA) suggested a different distribution of the OTUs in relation to water temperature and salinity. Vibrio was found, even with low abundances, at the highest salinities also, suggesting the salterns as a possible reservoir for the bacterium.

Published
2020

16. In memory of Stanislav Martinát (1976–2023)

Author

Frantál Bohumil, Bartke Stephan, Chodkowska-Miszczuk Justyna, Golubchikov Oleg, Greer-Wootten Bryn, Klapka Pavel, Klusáček Petr, Krzysztofik Robert, Kulla Marián, Ondráčková Miroslava, Pasqualetti Martin J., and Horst Dan Van Der

Subjects
stanislav martinat, in memoriam, czech republic, Geography (General), G1-922
Abstract

On Sunday, August 13, 2023, Stanislav Martinát – a respected Czech geographer and member of the Editorial Board of Moravian Geographical Reports journal – died after a short serious illness at the age of 47. Despite his relatively young age, Stanislav Martinát was one of the most productive and the most cited Czech geographers. He is the author or coauthor of over 100 peer-reviewed articles, of which more than 70 were published in journals indexed in the Web of Science database. This article is a collection of personal memories from people from different workplaces from several countries who had the opportunity to work with Stanislav (Standa) and to share a part of their life stage with him.

Published
2023
Full Text
View/download PDF

17. Molecular analysis and sport performance in élite rugby union players.

Author

Pasqualetti, Massimo, Canu, Giulia, Minazzato, L., Urbani, Andrea, Mordente, Alvaro, Galvani, Christel, Pasqualetti M., Canu G., Urbani A. (ORCID:0000-0001-9168-3174), Mordente A. (ORCID:0000-0003-3260-9796), Galvani C. (ORCID:0000-0002-0126-6033), Pasqualetti, Massimo, Canu, Giulia, Minazzato, L., Urbani, Andrea, Mordente, Alvaro, Galvani, Christel, Pasqualetti M., Canu G., Urbani A. (ORCID:0000-0001-9168-3174), Mordente A. (ORCID:0000-0003-3260-9796), and Galvani C. (ORCID:0000-0002-0126-6033)

Published
2019

18. The Small GTP-Binding Protein Rhes Influences Nigrostriatal-Dependent Motor Behavior During Aging

Author

Pinna, A, Napolitano, F, Pelosi, B, Di Maio, A, Wardas, J, Casu, Ma, Costa, G, Migliarini, S, Calabresi, P, Pasqualetti, M, Morelli, M, USIELLO, Alessandro, Pinna, A, Napolitano, Francesco, Pelosi, B, Di Maio, A, Wardas, J, Casu, Ma, Costa, G, Migliarini, S, Calabresi, P, Pasqualetti, M, Morelli, M, Usiello, A., Napolitano, F, and Usiello, Alessandro

Subjects
Male, Aging, Rhe, Tyrosine 3-Monooxygenase, Knockout, dopamine neuron, Inbred C57BL, Dopamine neurons, Midbrain, Mice, GTP-Binding Proteins, Animals, TH-positive neuron, Mice, Knockout, Behavior, Behavior, Animal, Animal, Dopaminergic Neurons, Rhes, Rasd2, dopamine neurons, midbrain, TH-positive neurons, Corpus Striatum, Mice, Inbred C57BL, Substantia Nigra, Settore MED/26 - NEUROLOGIA, nervous system, Neurology, Neurology (clinical), Psychomotor Performance
Abstract

BACKGROUND: Here we aimed to evaluate: (1) Rhes mRNA expression in mouse midbrain, (2) the effect of Rhes deletion on the number of dopamine neurons, (3) nigrostriatal-sensitive behavior during aging in knockout mice. METHODS: Radioactive in situ hybridization was assessed in adult mice. The beam-walking test was executed in 3-, 6- and 12-month-old mice. Immunohistochemistry of midbrain tyrosine hydroxylase (TH)-positive neurons was performed in 6- and 12-month-old mice. RESULTS: Rhes mRNA is expressed in TH-positive neurons of SNpc and the ventral tegmental area. Moreover, lack of Rhes leads to roughly a 20% loss of nigral TH-positive neurons in both 6- and 12-month-old mutants, when compared with their age-matched controls. Finally, lack of Rhes triggers subtle alterations in motor performance and coordination during aging. CONCLUSIONS: Our findings indicate a fine-tuning role of Rhes in regulating the number of TH-positive neurons of the substantia nigra and nigrostriatal-sensitive motor behavior during aging

Published
2016
Full Text
View/download PDF

19. The evolving energy landscapes of coal: Windows on the past and influences on the future

Author

Pasqualetti Martin J. and Frantál Bohumil

Subjects
coal mining, energy landscapes, energy transitions, coal phase-out, energy crisis, Geography (General), G1-922
Abstract

Coal energy landscapes have changed dramatically over the last decades, including geographic shifts in production and consumption, technological changes that have reduced labour demand and led to relatively new mining practices (e.g. invasive mountain-top approaches), changed economic footprints, a shutdown of capacities or a complete end of mining in many regions with massive impacts on regional and local economies, community well-being, social capital, et cetera. Then the Covid-19 pandemic and Russia´s invasion of Ukraine have fundamentally affected the global economy, disrupted energy markets, and shattered existing estimates about development trends, challenging the progress and speed of the low-carbon energy transition and coal phase-out. This article provides a brief reflection on the changing landscapes of coal and their possible futures, and serves as an introduction to the Special Issue of Moravian Geographical Reports on “The death of coal in the energy transition? Regional perspectives”.

Published
2022
Full Text
View/download PDF

25. Increased sensitivity of the alpha-2 neuronal nicotinic receptor causes familial epilepsy with nocturnal wandering and ictal fear

Author

Marini, C., Aridon, P., Di Resta, C., Brilli, E., Fusco, M., Politi, F., Parrini, E., Manfredi, I., Pisano, T., Pruna, D., Giulia Curia, Cianchetti, C., Pasqualetti, M., Becchetti, A., Guerrini, R., Casari, G., MARINI C, ARIDON P, DI RESTA C, BRILLI E, DE FUSCO M, POLITI, PARRINI E, MANFREDI I, PISANO T, PRUNA, CURIA G, CIANCHETTI C, PASQUALETTI M, BECCHETTI A, GUERRINI R, CASARI G, Marini, C, Aridon, P, DI RESTA, Chiara, Brilli, E, De Fusco, M, Politi, F, Parrini, E, Manfredi, I, Pisano, T, Pruna, D, Curia, G, Cianchetti, C, Pasqualetti, M, Becchetti, A, Guerrini, R, and Casari, GIORGIO NEVIO

Subjects
nicotinic receptor
Published
2006

27. Decreased Rhes mRNA levels in the brain of patients with Parkinson’s disease and MPTP-treated macaques

Author

Napolitano, F, Warren, E, Migliarini, S, Punzo, D, Errico, F, Li, Q, Thiolat, M, Vescovi, A, Calabresi, P, Bezard, E, Morelli, M, Konradi, C, Pasqualetti, M, Usiello, A, Warren, EB, Thiolat, ML, Vescovi, AL, Napolitano, F, Warren, E, Migliarini, S, Punzo, D, Errico, F, Li, Q, Thiolat, M, Vescovi, A, Calabresi, P, Bezard, E, Morelli, M, Konradi, C, Pasqualetti, M, Usiello, A, Warren, EB, Thiolat, ML, and Vescovi, AL

Abstract

In rodent and human brains, the small GTP-binding protein Rhes is highly expressed in virtually all dopaminoceptive striatal GABAergic medium spiny neurons, as well as in large aspiny cholinergic interneurons, where it is thought to modulate dopamine-dependent signaling. Consistent with this knowledge, and considering that dopaminergic neurotransmission is altered in neurological and psychiatric disorders, here we sought to investigate whether Rhes mRNA expression is altered in brain regions of patients with Parkinson’s disease (PD), Schizophrenia (SCZ), and Bipolar Disorder (BD), when compared to healthy controls (about 200 post-mortem samples). Moreover, we performed the same analysis in the putamen of non-human primate Macaca Mulatta, lesioned with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Overall, our data indicated comparable Rhes mRNA levels in the brain of patients with SCZ and BD, and their respective healthy controls. In sharp contrast, the putamen of patients suffering from PD showed a significant 35% reduction of this transcript, compared to healthy subjects. Interestingly, in line with observations obtained in humans, we found 27% decrease in Rhes mRNA levels in the putamen of MPTP-treated primates. Based on the established inhibitory influence of Rhes on dopamine-related responses, we hypothesize that its striatal downregulation in PD patients and animal models of PD might represent an adaptive event of the dopaminergic system to functionally counteract the reduced nigrostriatal innervation.

Published
2017

28. Decreased Rhes mRNA levels in the brain of patients with Parkinson’s disease and MPTP-treated macaques

Author

Napolitano, F., Warren, E. B., Migliarini, S., Punzo, D., Errico, F., Li, Q., Thiolat, M. -L., Vescovi, A. L., Calabresi, Paolo, Bezard, E., Morelli, M., Konradi, C., Pasqualetti, M., Usiello, A., Calabresi P. (ORCID:0000-0003-0326-5509), Napolitano, F., Warren, E. B., Migliarini, S., Punzo, D., Errico, F., Li, Q., Thiolat, M. -L., Vescovi, A. L., Calabresi, Paolo, Bezard, E., Morelli, M., Konradi, C., Pasqualetti, M., Usiello, A., and Calabresi P. (ORCID:0000-0003-0326-5509)

Abstract

In rodent and human brains, the small GTP-binding protein Rhes is highly expressed in virtually all dopaminoceptive striatal GABAergic medium spiny neurons, as well as in large aspiny cholinergic interneurons, where it is thought to modulate dopamine-dependent signaling. Consistent with this knowledge, and considering that dopaminergic neurotransmission is altered in neurological and psychiatric disorders, here we sought to investigate whether Rhes mRNA expression is altered in brain regions of patients with Parkinson’s disease (PD), Schizophrenia (SCZ), and Bipolar Disorder (BD), when compared to healthy controls (about 200 post-mortem samples). Moreover, we performed the same analysis in the putamen of non-human primate Macaca Mulatta, lesioned with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Overall, our data indicated comparable Rhes mRNA levels in the brain of patients with SCZ and BD, and their respective healthy controls. In sharp contrast, the putamen of patients suffering from PD showed a significant 35% reduction of this transcript, compared to healthy subjects. Interestingly, in line with observations obtained in humans, we found 27% decrease in Rhes mRNA levels in the putamen of MPTP-treated primates. Based on the established inhibitory influence of Rhes on dopamine-related responses, we hypothesize that its striatal downregulation in PD patients and animal models of PD might represent an adaptive event of the dopaminergic system to functionally counteract the reduced nigrostriatal innervation.

Published
2017

31. Primer informe de Aelurostrongylus abstrusus en el caracol de tierra Rumina decollata, en la Ciudad Autónoma de Buenos Aires

Author

Cardillo, Natalia Marina, Clemente, A., Pasqualetti, M., Borrás, P., Rosa, A., and Ribicich, M.

Subjects
Aelursotrongylus abstrusus, Intermediate host, Epidemiology, CIENCIAS AGRÍCOLAS, Otras Ciencias Veterinarias, Ciencias Veterinarias, purl.org/becyt/ford/4.3 [https], Rumina decollata, purl.org/becyt/ford/4 [https]
Abstract

Aelurostrongylus abstrusus (Railliet, 1898) is a worldwide distributed lungworm that affects wild and domestic cats, causing bronchopneumonia of varying intensity. Cats became infected by eating slugs and snails with third infective stage larvae (L3). The aim of the study was to describe the presence of A. abstrusus in R. decollate snails. R. decollata specimens and samples of cats’ faeces were collected from the open spaces of a public institution of Buenos Aires city, inhabited by a stray cat population. Cats’ faeces were processed by Baermman´s technique and snails were digested in pool, by artificial digestion method. First stage larvae of A. abstrusus were recovered from 35.30 % (6/17) of the sampled faeces. An 80 % (20/25) snails pools were positive for the second and third larval stages. Mean value of total larvae recovered per pool was 150.64 and mean value of L3/pool was 93.89. This is the first report of the development of A. abstrusus infective larvae in R. decollate snail as intermediate host, since the relationship between high levels of infection in snails and in cats’ faeces could be demonstrated in cats’ habitat. Aelurostrongylus abstrusus (Railliet, 1898) es un helminto pulmonar mundialmente distribuido que afecta a los gatos, causando bronconeumonias de variada intensidad. La infección se produce por ingestión de babosas y caracoles terrestres con larvas infectantes (L3). El objetivo del estudio fue describir la presencia de A. abstrusus en el caracol R. decollata. Se recolectaron muestras de heces felinas y caracoles presentes en una institución pública de la Ciudad Autónoma de Buenos Aires, habitada por una población de gatos sin propietario. Las heces fueron procesadas mediante la técnica de Baermman y los caracoles fueron digeridos en pool por digestión artificial enzimática. Larvas de primer estadio (L1) de A. abstrusus fueron recuperadas en el 35,30% (6/17) de las heces. El 80% (20/25) de los pooles de caracoles presentó larvas de segundo y tercer estadio. El promedio de larvas totales recuperado por pool fue de 150,64 y el valor medio de L3/pool fue de 93.89. Este es el primer hallazgo del desarrollo de larvas infectivas de A. abstrusus en el caracol doméstico R. decollata. Los altos niveles de infección encontrados en los caracoles y en las heces de los gatos demuestran el potencial de R. decollata como hospedador intermediario de A. abstrusus. Fil: Cardillo, Natalia Marina. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Area de Parasitología y Enfermedades Parasitarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Clemente, A.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Area de Parasitología y Enfermedades Parasitarias; Argentina Fil: Pasqualetti, M.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Area de Parasitología y Enfermedades Parasitarias; Argentina Fil: Borrás, P.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Area de Parasitología y Enfermedades Parasitarias; Argentina Fil: Rosa, A.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Area de Parasitología y Enfermedades Parasitarias; Argentina Fil: Ribicich, M.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Area de Parasitología y Enfermedades Parasitarias; Argentina

Published
2014

32. The Small GTP-Binding Protein Rhes Influences Nigrostriatal-Dependent Motor Behavior During Aging

Author

Pinna, A., Napolitano, F., Pelosi, B., Di Maio, A., Wardas, J., Casu, M. A., Costa, G., Migliarini, S., Calabresi, Paolo, Pasqualetti, M., Morelli, M., Usiello, A., Calabresi P. (ORCID:0000-0003-0326-5509), Pinna, A., Napolitano, F., Pelosi, B., Di Maio, A., Wardas, J., Casu, M. A., Costa, G., Migliarini, S., Calabresi, Paolo, Pasqualetti, M., Morelli, M., Usiello, A., and Calabresi P. (ORCID:0000-0003-0326-5509)

Abstract

Background: Here we aimed to evaluate: (1) Rhes mRNA expression in mouse midbrain, (2) the effect of Rhes deletion on the number of dopamine neurons, (3) nigrostriatal-sensitive behavior during aging in knockout mice. Methods: Radioactive in situ hybridization was assessed in adult mice. The beam-walking test was executed in 3-, 6- and 12-month-old mice. Immunohistochemistry of midbrain tyrosine hydroxylase (TH)-positive neurons was performed in 6- and 12-month-old mice. Results: Rhes mRNA is expressed in TH-positive neurons of SNpc and the ventral tegmental area. Moreover, lack of Rhes leads to roughly a 20% loss of nigral TH-positive neurons in both 6- and 12-month-old mutants, when compared with their age-matched controls. Finally, lack of Rhes triggers subtle alterations in motor performance and coordination during aging. Conclusions: Our findings indicate a fine-tuning role of Rhes in regulating the number of TH-positive neurons of the substantia nigra and nigrostriatal-sensitive motor behavior during aging.

Published
2016

34. Book reviews

Author

Orishimo, Isao, Lindsey, Robin, Cutter, Susan L., Hall, Jr., W. W., Wright, Paul, Krotki, Karol J., Solomon, Barry D., Lane, Theodore, Calzonetti, Frank J., Copes, Parzival, Pasqualetti, M. J., and Chappelle, Daniel E.

Published
1986
Full Text
View/download PDF

36. The NoEMi (Noise Frequency Event Miner) framework

Author

Accadia, T., Acernese, F., Agathos, M., Astone, P., Ballardin, G., Barone, F., Barsuglia, M., Basti, Andrea, Bauer, T. h. S., Bebronne, M., Bejger, M., Beker, M. G., Bitossi, M., Bizouard, M. A., Blom, M., Bondu, F., Bonelli, L., Bonnand, R., Boschi, V., Bosi, L., Bouhou, B., Braccini, S., Bradaschia, C., Branchesi, M., Briant, T., Brillet, A., Brisson, V., Bulik, T., Bulten, H. J., Buskulic, D., Buy, C., Calloni, E., Canuel, B., Carbognani, F., Cavalier, F., Cavalieri, R., Cella, G., Cesarini, E., Chaibi, O., Chassande, Mottin, Chincarini, E., Chiummo, A., Cleva, A., Coccia, F., Cohadon, E., P. F., Colacino, C. N., Colas, Colla, J., Colombini, A., Conte, M., Coulon, A., J. P., Cuoco, D'Antonio, E., Dattilo, S., Davier, V., Day, M., Rosa, De, Debreczeni, R., Del, Pozzo, Fiore, Di, DI LIETO, Alberto, Di Paolo Emilio, Virgilio, Di, Dietz, A., Drago, A., Endröczi, M., Fafone, G., Ferrante, Isidoro, Fidecaro, Francesco, Fiori, F., Flaminio, I., Forte, R., L. A., Fournier, J. D., Franc, Franco, J., Frasca, S., Frasconi, S., Galimberti, F., Gammaitoni, M., Garufi, L., Gáspár, F., M. E., Gemme, Genin, G., Gennai, E., Giazotto, A., Gouaty, A., Granata, R., Greverie, M., Guidi, C., G. M., Hayau, J. F., Heidmann, Heitmann, A., Hello, H., Hemming, P., Jaranowski, G., Jonker, P., R. J. G., Kasprzack, Kowalska, M., Królak, I., Leroy, A., Letendre, N., Li, N., T. G. F., Liguori, Lorenzini, N., Loriette, M., Losurdo, V., Majorana, G., Maksimovic, E., Malvezzi, I., Man, V., Mantovani, N., Marchesoni, M., Marion, F., Marque, F., Martelli, J., Masserot, F., Michel, A., Milano, C., Minenkov, L., Mohan, Y., Morgado, M., Morgia, N., Mosca, A., Mours, S., Naticchioni, B., Nocera, L., Palladino, F., Palomba, L., Paoletti, C., Paoletti, F., Parisi, R., Pasqualetti, M., Passaquieti, Roberto, Passuello, R., Persichetti, D., Piergiovanni, G., Pietka, F., Pinard, M., Poggiani, Rosa, Prato, M., Prodi, G. A., Punturo, M., Puppo, P., Rabeling, D. S., Racz, I., Rapagnani, P., Re, V., Regimbau, T., Ricci, F., Robinet, F., Rocchi, A., Rolland, L., Romano, R., Rosinska, D., Ruggi, P., Sassolas, B., Sentenac, D., Sperandio, L., Sturani, R., Swinkels, B., Tacca, M., Taffarello, L., Ter, Braack, Toncelli, Alessandra, Tonelli, Mauro, Torre, M., Tournefier, O., Travasso, E., Vajente, F., Van Den Brand, J. F. J., Van Den Broeck, Van Der Putten, Vasuth, S., Vavoulidis, M., Vedovato, M., Verkindt, G., Vetrano, D., Viceré, F., Vinet, A., J. Y., Vitale, Vocca, S., Ward, H., R. L., Was, Yamamoto, M., Yvert, K., Zadrozny, M., Zendri, A., J. P., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), APC - Cosmologie, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique de Rennes (IPR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des matériaux avancés (LMA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux (ARTEMIS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Observatoire de la Côte d'Azur (OCA), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), APC - Gravitation (APC-Gravitation), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Istituto Nazionale di Fisica Nucleare [Sezione di Roma 1] (INFN), Istituto Nazionale di Fisica Nucleare, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL), Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Université de Poitiers-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Research Institute of Electronics, University of Shizuoka, VIRGO, Laboratoire d'Annecy de Physique des Particules ( LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ), Physique Corpusculaire et Cosmologie - Collège de France ( PCC ), Collège de France ( CdF ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ) -Collège de France ( CdF ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ) -AstroParticule et Cosmologie ( APC - UMR 7164 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Centre National de la Recherche Scientifique ( CNRS ) -Observatoire de Paris-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Laboratoire de l'Accélérateur Linéaire ( LAL ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Physique de Rennes ( IPR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire des matériaux avancés ( LMA ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), AstroParticule et Cosmologie ( APC - UMR 7164 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux ( ARTEMIS ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de la Côte d'Azur, Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Observatoire de la Côte d'Azur ( OCA ), Centre National de la Recherche Scientifique ( CNRS ), APC - Gravitation ( APC-Gravitation ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Max-Planck-Institut für Gravitationsphysik (Albert-Einstein-Institut), Max-Planck-Institut-Max-Planck-Institut, Istituto Nazionale di Fisica Nucleare [Sezione di Roma 1] ( INFN ), ESPCI ParisTech, Institut de Chimie des Milieux et Matériaux de Poitiers ( IC2MP ), Université de Poitiers-Centre National de la Recherche Scientifique ( CNRS ), Institut de recherches sur la catalyse et l'environnement de Lyon ( IRCELYON ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Université Nice Sophia Antipolis (... - 2019) (UNS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), T., Accadia, F., Acernese, M., Agatho, P., Astone, G., Ballardin, F., Barone, M., Barsuglia, A., Basti, Th S., Bauer, M., Bebronne, M., Bejger, M. G., Beker, M., Bitossi, M. A., Bizouard, M., Blom, F., Bondu, L., Bonelli, R., Bonnand, V., Boschi, L., Bosi, B., Bouhou, S., Braccini, C., Bradaschia, M., Branchesi, T., Briant, A., Brillet, V., Brisson, T., Bulik, H. J., Bulten, D., Buskulic, C., Buy, Calloni, Enrico, B., Canuel, F., Carbognani, F., Cavalier, R., Cavalieri, G., Cella, E., Cesarini, O., Chaibi, E., Chassande Mottin, A., Chincarini, A., Chiummo, F., Cleva, E., Coccia, P. F., Cohadon, C. N., Colacino, J., Cola, A., Colla, M., Colombini, A., Conte, J. P., Coulon, E., Cuoco, S., D'Antonio, V., Dattilo, M., Davier, R., Day, DE ROSA, Rosario, G., Debreczeni, W., Del Pozzo, L., Di Fiore, A., Di Lieto, M., Di Paolo Emilio, A., Di Virgilio, A., Dietz, M., Drago, G., Endröczi, V., Fafone, I., Ferrante, F., Fidecaro, I., Fiori, R., Flaminio, L. A., Forte, J. D., Fournier, J., Franc, S., Franco, S., Frasca, F., Frasconi, M., Galimberti, L., Gammaitoni, Garufi, Fabio, M. E., Gáspár, G., Gemme, E., Genin, A., Gennai, A., Giazotto, R., Gouaty, M., Granata, C., Greverie, G. M., Guidi, J. F., Hayau, A., Heidmann, H., Heitmann, P., Hello, G., Hemming, P., Jaranowski, R. J. G., Jonker, M., Kasprzack, I., Kowalska, A., Królak, N., Leroy, N., Letendre, T. G. F., Li, N., Liguori, M., Lorenzini, V., Loriette, G., Losurdo, E., Majorana, I., Maksimovic, V., Malvezzi, N., Man, M., Mantovani, F., Marchesoni, F., Marion, J., Marque, F., Martelli, A., Masserot, C., Michel, Milano, Leopoldo, Y., Minenkov, M., Mohan, N., Morgado, A., Morgia, S., Mosca, B., Mour, L., Naticchioni, F., Nocera, L., Palladino, C., Palomba, F., Paoletti, R., Paoletti, M., Parisi, A., Pasqualetti, R., Passaquieti, D., Passuello, G., Persichetti, F., Piergiovanni, M., Pietka, L., Pinard, R., Poggiani, M., Prato, G. A., Prodi, M., Punturo, P., Puppo, D. S., Rabeling, I., Rácz, P., Rapagnani, V., Re, T., Regimbau, F., Ricci, F., Robinet, A., Rocchi, L., Rolland, R., Romano, D., Rosińska, P., Ruggi, B., Sassola, D., Sentenac, L., Sperandio, R., Sturani, B., Swinkel, M., Tacca, L., Taffarello, A. P. M., ter Braack, A., Toncelli, M., Tonelli, O., Torre, E., Tournefier, F., Travasso, G., Vajente, J. F. J., van den Brand, C., Van Den Broeck, S., van der Putten, M., Vasuth, M., Vavoulidi, G., Vedovato, D., Verkindt, F., Vetrano, A., Viceré, J. Y., Vinet, S., Vitale, H., Vocca, R. L., Ward, M., Wa, K., Yamamoto, M., Yvert, A., Zadroźny, J. P., Zendri, Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-AstroParticule et Cosmologie (APC (UMR_7164)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Max-Planck-Institut für Gravitationsphysik ( Albert-Einstein-Institut ) (AEI), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)

Subjects
History, Gravitational wave detectors and experiments, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], 04.80.Nn, 95.55.Ym, 07.60.Ly, [ PHYS.ASTR.CO ] Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], computer.software_genre, 01 natural sciences, Education, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Interferometers, Data acquisition, Settore FIS/05 - Astronomia e Astrofisica, 0103 physical sciences, 010303 astronomy & astrophysics, Physics, Data processing, Detection of gravitational waves, astrophysics, 010308 nuclear & particles physics, Gravitational wave, Event (computing), Settore FIS/01 - Fisica Sperimentale, gravitational waves, interferometers, Computer Science Applications, Interferometry, Noise, [ SDU.ASTR.CO ] Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Line (geometry), Data mining, User interface, computer
Abstract

International audience; The data collected by a gravitational wave interferometer are inevitably affected by instrumental artefacts and environmental disturbances. In particular, for continuous gravitational wave (CW) studies it is important to detect narrow-band disturbances (the so-called "noise lines") during science runs, and to help scientists to identify and possibly remove or mitigate their sources. The NoEMi (Noise Frequency Event Miner) framework exploits some of the algorithms implemented for the CW search to identify, on a daily basis, the frequency lines observed in the Virgo science data and in a subset of the environmental sensors, looking for lines that match in frequency. A line tracker algorithm reconstructs the lines over time, and stores them in a database, which is made accesible via a web interface. We describe the workflow of NoEMi, providing examples of its use for the investigation of noise lines in past Virgo runs (VSR2, VSR3) and in the most recent run (VSR4).

Published
2011
Full Text
View/download PDF

38. Rasd2 Modulates Psychotomimetic Drug Effects in Mice and Schizophrenia-related Phenotypes in Humans

Author

Vitucci, D., primary, Di Giorgio, A., additional, Napolitano, F., additional, Pelosi, B., additional, Blasi, G., additional, Errico, F., additional, Attrotto, M.T., additional, Gelao, B., additional, Fazio, L., additional, Taurisano, P., additional, Di Maio, A., additional, Marsili, V., additional, Pasqualetti, M., additional, Bertolino, A., additional, and Usiello, A., additional

Published
2015
Full Text
View/download PDF

42. Book reviews

Author

Yamaji, Haruhiko, Poiker, Thomas K., Ibrahim, Fouad, Richter, Dieter, Kunkel, G., and Pasqualetti, M. J.

Published
1984
Full Text
View/download PDF

44. Dysfunctional dopaminergic neurotransmission in asocial BTBR mice

Author

Squillace, M, primary, Dodero, L, additional, Federici, M, additional, Migliarini, S, additional, Errico, F, additional, Napolitano, F, additional, Krashia, P, additional, Di Maio, A, additional, Galbusera, A, additional, Bifone, A, additional, Scattoni, M L, additional, Pasqualetti, M, additional, Mercuri, N B, additional, Usiello, A, additional, and Gozzi, A, additional

Published
2014
Full Text
View/download PDF

47. Lack of brain serotonin affects postnatal development and serotonergic neuronal circuitry formation.

Author

University of Pisa - Department of Biology, Migliarini, S., Pacini, G., Pelosi, Barbara, Lunardi, G., Pasqualetti, M., University of Pisa - Department of Biology, Migliarini, S., Pacini, G., Pelosi, Barbara, Lunardi, G., and Pasqualetti, M.

Abstract

Despite increasing evidence suggests that serotonin (5-HT) can influence neurogenesis, neuronal migration and circuitry formation, the precise role of 5-HT on central nervous system (CNS) development is only beginning to be elucidated. Moreover, how changes in serotonin homeostasis during critical developmental periods may have etiological relevance to human mental disorders, remains an unsolved question. In this study we address the consequences of 5-HT synthesis abrogation on CNS development using a knock-in mouse line in which the tryptophan hydroxylase 2 (Tph2) gene is replaced by the eGFP reporter. We report that lack of brain 5-HT results in a dramatic reduction of body growth rate and in 60% lethality within the first 3 weeks after birth, with no gross anatomical changes in the brain. Thanks to the specific expression of the eGFP, we could highlight the serotonergic system independently of 5-HT immunoreactivity. We found that lack of central serotonin produces severe abnormalities in the serotonergic circuitry formation with a brain region- and time- specific effect. Indeed, we observed a striking reduction of serotonergic innervation to the suprachiasmatic and thalamic paraventricular nuclei, while a marked serotonergic hyperinnervation was found in the nucleus accumbens and hippocampus of Tph2∷eGFP mutants. Finally, we demonstrated that BDNF expression is significantly up-regulated in the hippocampus of mice lacking brain 5-HT, mirroring the timing of the appearance of hyperinnervation and thus unmasking a possible regulatory feedback mechanism tuning the serotonergic neuronal circuitry formation. On the whole, these findings reveal that alterations of serotonin levels during CNS development affect the proper wiring of the brain that may produce long-lasting changes leading to neurodevelopmental disorders.

Published
2013

Catalog

Books, media, physical & digital resources
See catalog results