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7. INTERACTION BETWEEN BETAMETHASONE AND VECURONIUM

Author

PARR, S. M., ROBINSON, B.J., REES, D., and GALLETLY, D. C.

Abstract

A possible interaction between betamethasone and vecuronium was examined in 20 rat phrenic nerve-hemidiaphragm preparations. Ten preparations were bathed in a physiological solution with betamethasone 1 μmol litre−1 added and, after a 30-min period were exposed to vecuronium at concentrations of 4, 6, 8 and 10 nmol litre−1 with vecuronium free washings between each exposure. Ten control experiments were performed also using a betamethasone-free bathing solution. In comparison with control, the betamethasone group had significantly (P = 0.0008) less depression of muscle contraction (twitch) force at all concentrations of vecuronium. The calculated EDX (50% depression of muscle contraction force) was 5.65 μmol litre−1 for controls and 7.39 μmol litre−1 for betamethasone- pretreated preparations. This study confirms our previous clinical observations that an interaction occurs between vecuronium and betamethasone which is characterized by resistance to neuromuscular block.

Published
1991
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8. Interaction between betamethasone and vecuronium.

Author

Parr SM, Robinson BJ, Rees D, and Galletly DC

Subjects
Animals, Depression, Chemical, Dose-Response Relationship, Drug, Drug Interactions, Male, Muscle Contraction drug effects, Organ Culture Techniques, Rats, Betamethasone pharmacology, Diaphragm drug effects, Phrenic Nerve drug effects, Vecuronium Bromide pharmacology
Abstract

A possible interaction between betamethasone and vecuronium was examined in 20 rat phrenic nerve-hemidiaphragm preparations. Ten preparations were bathed in a physiological solution with betamethasone 1 mumol litre-1 added and, after a 30-min period were exposed to vecuronium at concentrations of 4, 6, 8 and 10 mumol litre-1 with vecuronium free washings between each exposure. Ten control experiments were performed also using a betamethasone-free bathing solution. In comparison with control, the betamethasone group had significantly (P = 0.0008) less depression of muscle contraction (twitch) force at all concentrations of vecuronium. The calculated ED50 (50% depression of muscle contraction force) was 5.65 mumol litre-1 for controls and 7.39 mumol litre-1 for betamethasone-pretreated preparations. This study confirms our previous clinical observations that an interaction occurs between vecuronium and betamethasone which is characterized by resistance to neuromuscular block.

Published
1991
Full Text
View/download PDF

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