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8. Disturbed sex hormone milieu in males and females with major depressive disorder and low-grade inflammation

Author

Lombardo, Giulia, Mondelli, Valeria, Worrell, Courtney, Sforzini, Luca, Mariani, Nicole, Nikkheslat, Naghmeh, Nettis, Maria A., Kose, Melisa, Zajkowska, Zuzanna, Cattaneo, Annamaria, Pointon, Linda, Turner, Lorinda, Cowen, Philip J., Drevets, Wayne C., Cavanagh, Jonathan, Harrison, Neil A., Bullmore, Edward T., Dazzan, Paola, and Pariante, Carmine M.

Published
2024
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9. Extreme deviations from the normative model reveal cortical heterogeneity and associations with negative symptom severity in first-episode psychosis from the OPTiMiSE and GAP studies

Author

Worker, Amanda, Berthert, Pierre, Lawrence, Andrew J., Kia, Seyed Mostafa, Arango, Celso, Dinga, Richard, Galderisi, Silvana, Glenthøj, Birte, Kahn, René S., Leslie, Anoushka, Murray, Robin M., Pariante, Carmine M., Pantelis, Christos, Weiser, Mark, Winter-van Rossum, Inge, McGuire, Philip, Dazzan, Paola, and Marquand, Andre F.

Published
2023
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10. Network analysis of inflammation and symptoms in recent onset schizophrenia and the influence of minocycline during a clinical trial

Author

Herniman, Sarah E., Wood, Stephen J., Khandaker, Golam, Dazzan, Paola, Pariante, Carmine M., Barnes, Nicholas M., Krynicki, Carl R., Nikkheslat, Naghmeh, Vincent, Rachel C., Roberts, Alex, Giordano, Annalisa, Watson, Andrew, Suckling, John, Barnes, Thomas R. E., Husain, Nusrat, Jones, Peter B., Joyce, Eileen, Lawrie, Stephen M., Lewis, Shôn, Deakin, Bill, and Upthegrove, Rachel

Published
2023
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11. Feasibility, clinical efficacy, and well-being outcomes of an online singing intervention for postnatal depression in the UK: SHAPER-PNDO, a single-arm clinical trial

Author

Bind, Rebecca H., Sawyer, Kristi, Hazelgrove, Katie, Rebecchini, Lavinia, Miller, Celeste, Ahmed, Subeyda, Dazzan, Paola, Sevdalis, Nick, Bakolis, Ioannis, Davis, Rachel, Lopez, Maria Baldellou, Woods, Anthony, Crane, Nikki, Manoharan, Manonmani, Burton, Alexandra, Dye, Hannah, Osborn, Tim, Greenwood, Lorna, Perkins, Rosie, Fancourt, Daisy, Pariante, Carmine M., and Estevao, Carolina

Published
2023
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12. A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials

Author

Sforzini, Luca, Worrell, Courtney, Kose, Melisa, Anderson, Ian M, Aouizerate, Bruno, Arolt, Volker, Bauer, Michael, Baune, Bernhard T, Blier, Pierre, Cleare, Anthony J, Cowen, Philip J, Dinan, Timothy G, Fagiolini, Andrea, Ferrier, I Nicol, Hegerl, Ulrich, Krystal, Andrew D, Leboyer, Marion, McAllister-Williams, R Hamish, McIntyre, Roger S, Meyer-Lindenberg, Andreas, Miller, Andrew H, Nemeroff, Charles B, Normann, Claus, Nutt, David, Pallanti, Stefano, Pani, Luca, Penninx, Brenda WJH, Schatzberg, Alan F, Shelton, Richard C, Yatham, Lakshmi N, Young, Allan H, Zahn, Roland, Aislaitner, Georgios, Butlen-Ducuing, Florence, Fletcher, Christine, Haberkamp, Marion, Laughren, Thomas, Mäntylä, Fanni-Laura, Schruers, Koen, Thomson, Andrew, Arteaga-Henríquez, Gara, Benedetti, Francesco, Cash-Gibson, Lucinda, Chae, Woo Ri, De Smedt, Heidi, Gold, Stefan M, Hoogendijk, Witte JG, Mondragón, Valeria Jordán, Maron, Eduard, Martynowicz, Jadwiga, Melloni, Elisa, Otte, Christian, Perez-Fuentes, Gabriela, Poletti, Sara, Schmidt, Mark E, van de Ketterij, Edwin, Woo, Katherine, Flossbach, Yanina, Ramos-Quiroga, J Antoni, Savitz, Adam J, and Pariante, Carmine M

Subjects
Clinical Trials and Supportive Activities, Depression, Clinical Research, Mental Health, Brain Disorders, Serious Mental Illness, Major Depressive Disorder, Good Health and Well Being, Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant, Humans, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD) as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the present document we used a Delphi-method-based consensus approach to define TRD and PRD and to serve as operational criteria for future clinical studies, especially if conducted for regulatory purposes. We reviewed the literature and brought together a group of international experts (including clinicians, academics, researchers, employees of pharmaceutical companies, regulatory bodies representatives, and one person with lived experience) to evaluate the state-of-the-art and main controversies regarding the current classification. We then provided recommendations on how to design clinical trials, and on how to guide research in unmet needs and knowledge gaps. This report will feed into one of the main objectives of the EUropean Patient-cEntric clinicAl tRial pLatforms, Innovative Medicines Initiative (EU-PEARL, IMI) MDD project, to design a protocol for platform trials of new medications for TRD/PRD.

Published
2022

13. A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression

Author

Jauhar, Sameer, Arnone, Danilo, Baldwin, David S., Bloomfield, Michael, Browning, Michael, Cleare, Anthony J., Corlett, Phillip, Deakin, J. F. William, Erritzoe, David, Fu, Cynthia, Fusar-Poli, Paolo, Goodwin, Guy M., Hayes, Joseph, Howard, Robert, Howes, Oliver D., Juruena, Mario F., Lam, Raymond W., Lawrie, Stephen M., McAllister-Williams, Hamish, Marwaha, Steven, Matuskey, David, McCutcheon, Robert A., Nutt, David J., Pariante, Carmine, Pillinger, Toby, Radhakrishnan, Rajiv, Rucker, James, Selvaraj, Sudhakar, Stokes, Paul, Upthegrove, Rachel, Yalin, Nefize, Yatham, Lakshmi, Young, Allan H., Zahn, Roland, and Cowen, Philip J.

Published
2023
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14. Diet and depression: future needs to unlock the potential

Author

Marx, Wolfgang, Lane, Melissa M, Hockey, Meghan, Aslam, Hajara, Walder, Ken, Borsini, Alessandra, Firth, Joseph, Pariante, Carmine M, Berding, Kirsten, Cryan, John F, Clarke, Gerard, Craig, Jeffrey M, Su, Kuan-Pin, Mischoulon, David, Gomez-Pinilla, Fernando, Foster, Jane A, Cani, Patrice D, Thuret, Sandrine, Staudacher, Heidi M, Sánchez-Villegas, Almudena, Arshad, Husnain, Akbaraly, Tasnime, O’Neil, Adrienne, and Jacka, Felice N

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical and Health Psychology, Clinical Sciences, Psychology, Depression, Diet, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Published
2022

17. Current state-of-the-art and gaps in platform trials: 10 things you should know, insights from EU-PEARL

Author

Sánchez-Montalva, Adrian, Estevez, Ana Belén, Sánchez, Àlex, Sanjuan, Anna, Sena, Elena, Granados, Emma, Arévalo de Andrés, Esther, Nuñez, Fátima, Arteaga, Gara, Fuentes Ruiz, Gabriela Perez, Fernández, Guillermo, Rivera-Esteban, Jesus, Comella, Joan, Ramos-Quiroga, Josep Antoni, Genescà, Joan, Espinosa, Juan, Pericàs, Juan Manuel, Murcia, Lada, Cash-Gibson, Lucinda, de Valles Silvosa, Maria, Barroso de Sousa, María Fernanda, Sánchez-Maroto Carrizo, Olga, Ibañez-Jiménez, Pol, Augustin, Salvador, Perez-Hoyos, Santiago, Rodríguez-Navarro, Sarai, Muñoz-Martínez, Sergio, Serres, Silvia, Kalko, Susana, Michon, Amelie, Ussi, Anton, Lydall, Ben, van de Ketterij, Edwin, Quiles, Ignacio, Carapina, Tamara, Kumaus, Constantin, Ramazanova, Dariga, Meyer, Elias Laurin, Koenig, Franz, Roig, Marta Bofill, Brunner, Martin, Posch, Martin, Krotka, Pavla, Zehetmayer, Sonja, Carton, Charlotte, Legius, Eric, Begum, Amina, Pariante, Carmine, Worrell, Courtney, Lombardo, Giulia, Sforzini, Luca, Brown, Mollie, Gullet, Nancy, Amasi-Hartoonian, Nare, Ferner, Rosalie, Kose, Melisa, Spitaleri, Andrea, Ghodousi, Arash, Di Serio, Clelia, Cirillo, Daniela, Cugnata, Federica, Saluzzo, Francesca, Benedetti, Francesco, Scarale, Maria Giovanna, Zini, Michela, Rancoita, Paola Maria, Alagna, Riccardo, Poletti, Sara, Dhaenens, Britt, Van Der Lei, Johan, de Steenwinkel, Jurriaan, Moinat, Maxim, Oostenbrink, Rianne, Hoogendijk, Witte, Hölscher, Michael, Heinrich, Norbert, Otte, Christian, Potratz, Cornelia, Zocholl, Dario, Kulakova, Eugenia, Tacke, Frank, Brasanac, Jelena, Leubner, Jonas, Krajewska, Maja, Freitag, Michaela Maria, Gold, Stefan, Zoller, Thomas, Chae, Woo Ri, Daniel, Christel, Kara, Leila, Vaterkowski, Morgan, Griffon, Nicolas, Wolkenstein, Pierre, Pais, Raluca, Ratziu, Vlad, Voets, David, Maes, Christophe, Kalra, Dipak, Thienpoint, Geert, Deckerck, Jens, Lea, Nathan, Singleton, Peter, Viele, Kert, Jacko, Peter, Berry, Scott, Parke, Tom, Aydin, Burç, Kubiak, Christine, Demotes, Jacques, Ueda, Keiko, Matei, Mihaela, Contrino, Sergio, Röhl, Claas, Cordero, Estefania, Greenhalgh, Fiona, Jarke, Hannes, Angelova, Juliana, Boudes, Mathieu, Dressler, Stephan, Strammiello, Valentina, Anstee, Quentin, Gutierrez-Ibarluzea, Iñaki, Otte, Maximilian, Heimbach, Natalie, Hofner, Benjamin, Burgwinkel, Cora, Kaestel, Hue, Hees, Katharina, Nguyen, Quynh, Prieto-Alhambra, Daniel, Tan, Eng Hooi (Cheryl), Raviglione, Mario, de Colombani, Pierpaolo, Villa, Simone, Maron, Eduard, Evans, Gareth, Savitz, Adam J., Van Dessel, Ann, Duca, Anna, Kaminski, Anne, Wouters, Bie, Porter, Brandon, Charron, Catherine, Spiertz, Cecile, Zizzamia, Christopher, Millar, Daniel, Hasselbaink, Danny, Orr, David, Kesters, Divya, Hubin, Ellen, Davies, Emma, Didden, Eva-Maria, Guz, Gabriela, Verstraete, Evelyn, Mao, Gary, Capuano, George, Martynowicz, Heddie, De Smedt, Heidi, Larsson, Ingela, Bruegelmans, Ines, Coste, Isabelle, Gonzalez Moreno, Jesus Maria, Niewczas, Julia, Xu, Jiajun, Rombouts, Karin, Woo, Katherine, Wuyts, Kathleen, Hersh, Kathryn, Oldenburg, Khrista, Zhang, Lingjiao, Schmidt, Mark, Szuch, Mark, Todorovic, Marija, Mangelaars, Maartje, Grewal, Melissa, Sandor, Molli, Di Prospero, Nick, Van Houten, Pamela, Minnick, Pansy, Bastos, Polyana, Patrizi, Robert, Morello, Salvatore, De Wilde, Severijn, Sun, Tao, Kline, Timothy, de Marez, Tine, Mielke, Tobias, Reijns, Tom, Popova, Vanina, Flossbach, Yanina, Tymofyeyev, Yevgen, De Groote, Zeger, Sverdlov, Alex, Bobirca, Alexandra, Krause, Annekatrin, Bobrica, Catalin, Heintz, Daniela, Magirr, Dominic, Glimm, Ekkehard, Baffert, Fabienne, Castiglione, Federica, Caruso, Franca, Patalano, Francesco, Bretz, Frank, Heimann, Guenter, Carbarns, Ian, Rodríguez, Ignacio, Ratescu, Ioana, Hampson, Lisa, Pedrosa, Marcos, Hark, Mareile, Mesenbrink, Peter, Penna, Sabina Hernandez, Bergues-Lang, Sarah, Baltes-Engler, Susanne, Arsiwala, Tasneem, Mondragon, Valeria Jordan, Guo, Hua, Da Costa, Jose Leite, Burman, Carl-Fredrik, Kirk, George, Aaes-Jørgensen, Anders, Dirach, Jorgen, Kjær, Mette Skalshøi, Martin, Alexandra, Hristov, Diyan, Rousseaux, Florent, Hittel, Norbert, Dornheim, Robert, Evans, Daniel, Sykes, Nick, Couvert, Camille, Leuven, Catherine, Notelet, Loïc, Gidh-Jain, Madhavi, Jouannin, Mathieu, Ammour, Nadir, Pierre, Suzanne, Haufe, Volker, Dong, Yingwen, Dubanchet, Catherine, de Préville, Nathalie, Baltauss, Tania, Jian, Zhu, Shnider, Sara, Bar-El, Tal, Bakker, Annette, Nievo, Marco, Iloeje, Uche, Conradie, Almari, Auffarrth, Ece, Lombard, Leandra, Benhayoun, Majda, Olugbosi, Morounfolu, Seidel, Stephanie S., Gumí, Berta, Guzmán, Claudia García, Molero, Eva, Pairó, Gisela, Machin, Núria, Cardelús, Raimon, Ramasastry, Saira, Pelzer, Saskia, Kremer, Andreas, Lindfors, Erno, Lynch, Chris, Spiertz, Cécile, Machín, Núria, and Pericàs, Juan M.

Published
2024
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19. A multicentre validation study of the diagnostic value of plasma neurofilament light.

Author

Ashton, Nicholas J, Janelidze, Shorena, Al Khleifat, Ahmad, Leuzy, Antoine, van der Ende, Emma L, Karikari, Thomas K, Benedet, Andrea L, Pascoal, Tharick A, Lleó, Alberto, Parnetti, Lucilla, Galimberti, Daniela, Bonanni, Laura, Pilotto, Andrea, Padovani, Alessandro, Lycke, Jan, Novakova, Lenka, Axelsson, Markus, Velayudhan, Latha, Rabinovici, Gil D, Miller, Bruce, Pariante, Carmine, Nikkheslat, Naghmeh, Resnick, Susan M, Thambisetty, Madhav, Schöll, Michael, Fernández-Eulate, Gorka, Gil-Bea, Francisco J, López de Munain, Adolfo, Al-Chalabi, Ammar, Rosa-Neto, Pedro, Strydom, Andre, Svenningsson, Per, Stomrud, Erik, Santillo, Alexander, Aarsland, Dag, van Swieten, John C, Palmqvist, Sebastian, Zetterberg, Henrik, Blennow, Kaj, Hye, Abdul, and Hansson, Oskar

Subjects
Humans, Neurodegenerative Diseases, Down Syndrome, Neurofilament Proteins, False Positive Reactions, Cohort Studies, Predictive Value of Tests, Depression, Age Factors, Sex Factors, Reference Values, Aged, Middle Aged, Female, Male, Biomarkers, Cognitive Dysfunction
Abstract

Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King's College London (n = 805) and the Swedish BioFINDER study (n = 1,464). Plasma NfL was significantly increased in all cortical neurodegenerative disorders, amyotrophic lateral sclerosis and atypical parkinsonian disorders. We demonstrate that plasma NfL is clinically useful in identifying atypical parkinsonian disorders in patients with parkinsonism, dementia in individuals with Down syndrome, dementia among psychiatric disorders, and frontotemporal dementia in patients with cognitive impairment. Data-driven cut-offs highlighted the fundamental importance of age-related clinical cut-offs for disorders with a younger age of onset. Finally, plasma NfL performs best when applied to indicate no underlying neurodegeneration, with low false positives, in all age-related cut-offs.

Published
2021

23. Inflammatory subgroups of schizophrenia and their association with brain structure: A semi-supervised machine learning examination of heterogeneity

Author

Alexandros Lalousis, Paris, Schmaal, Lianne, Wood, Stephen J., L.E.P Reniers, Renate, Cropley, Vanessa L., Watson, Andrew, Pantelis, Christos, Suckling, John, Barnes, Nicholas M., Pariante, Carmine, Jones, Peter B., Joyce, Eileen, Barnes, Thomas R.E., Lawrie, Stephen M., Husain, Nusrat, Dazzan, Paola, Deakin, Bill, Shannon Weickert, Cynthia, and Upthegrove, Rachel

Published
2023
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24. Diet and depression: exploring the biological mechanisms of action

Author

Marx, Wolfgang, Lane, Melissa, Hockey, Meghan, Aslam, Hajara, Berk, Michael, Walder, Ken, Borsini, Alessandra, Firth, Joseph, Pariante, Carmine M, Berding, Kirsten, Cryan, John F, Clarke, Gerard, Craig, Jeffrey M, Su, Kuan-Pin, Mischoulon, David, Gomez-Pinilla, Fernando, Foster, Jane A, Cani, Patrice D, Thuret, Sandrine, Staudacher, Heidi M, Sánchez-Villegas, Almudena, Arshad, Husnain, Akbaraly, Tasnime, O’Neil, Adrienne, Segasby, Toby, and Jacka, Felice N

Subjects
Medical Biochemistry and Metabolomics, Biomedical and Clinical Sciences, Neurosciences, Obesity, Complementary and Integrative Health, Depression, Brain Disorders, Nutrition, Behavioral and Social Science, Mental Health, Oral and gastrointestinal, Mental health, Good Health and Well Being, Animals, Diet, Epigenesis, Genetic, Gastrointestinal Microbiome, Humans, Inflammation, Oxidative Stress, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

The field of nutritional psychiatry has generated observational and efficacy data supporting a role for healthy dietary patterns in depression onset and symptom management. To guide future clinical trials and targeted dietary therapies, this review provides an overview of what is currently known regarding underlying mechanisms of action by which diet may influence mental and brain health. The mechanisms of action associating diet with health outcomes are complex, multifaceted, interacting, and not restricted to any one biological pathway. Numerous pathways were identified through which diet could plausibly affect mental health. These include modulation of pathways involved in inflammation, oxidative stress, epigenetics, mitochondrial dysfunction, the gut microbiota, tryptophan-kynurenine metabolism, the HPA axis, neurogenesis and BDNF, epigenetics, and obesity. However, the nascent nature of the nutritional psychiatry field to date means that the existing literature identified in this review is largely comprised of preclinical animal studies. To fully identify and elucidate complex mechanisms of action, intervention studies that assess markers related to these pathways within clinically diagnosed human populations are needed.

Published
2021

29. A Modest Increase in 11C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index

Author

Wlazly, Dominika, Dickinson, Amber, Foster, Andy, Knight, Clare, Leckey, Claire, Morgan, Paul, Morgan, Angharad, O'Hagan, Caroline, Touchard, Samuel, Khan, Shahid, Murphy, Phil, Parker, Christine, Patel, Jai, Richardson, Jill, Acton, Paul, Austin, Nigel, Bhattacharya, Anindya, Carruthers, Nick, de Boer, Peter, Drevets, Wayne, Isaac, John, Jones, Declan, Kemp, John, Kolb, Hartmuth, Nye, Jeff, Wittenberg, Gayle, Barker, Gareth, Bogdanova, Anna, Byrom, Heidi, Cash, Diana, Cattaneo, Annamaria, Enache, Daniela, Gee, Tony, Hastings, Caitlin, Kose, Melisa, Lombardo, Giulia, Mariani, Nicole, McLaughlin, Anna, Mondelli, Valeria, Nettis, Maria, Nikkheslat, Naghmeh, Pariante, Carmine, Randall, Karen, Schubert, Julia, Sforzini, Luca, Sheridan, Hannah, Simmons, Camilla, Singh, Nisha, Turkheimer, Federico, Van Loo, Vicky, Veronese, Mattia, Rodriguez, Marta Vicente, Wood, Toby, Worrell, Courtney, Zajkowska, Zuzanna, Campbell, Brian, Egebjerg, Jan, Eriksson, Hans, Gastambide, Francois, Adams, Karen Husted, Jeggo, Ross, Moeller, Thomas, Nelson, Bob, Plath, Niels, Thomsen, Christian, Pederson, Jan Torleif, Zorn, Stevin, Deith, Catherine, Farmer, Scott, McClean, John, McPherson, Andrew, Penandes, Nagore, Scouller, Paul, Sutherland, Murray, Attenburrow, Mary Jane, Benjamin, Jithen, Jones, Helen, Mada, Fran, Oladejo, Akintayo, Smith, Katy, Balice-Gordon, Rita, Binneman, Brendon, Duerr, James, Fullerton, Terence, Goli, Veeru, Hughes, Zoe, Piro, Justin, Samad, Tarek, Sporn, Jonathan, Hoskins, Liz, Kohn, Charmaine, Wilcock, Lauren, Aigbirhio, Franklin, Bhatti, Junaid, Bullmore, Ed, Chamberlain, Sam, Correia, Marta, Crofts, Anna, Fryer, Tim, Graves, Martin, Hatton, Alex, Kitzbichler, Manfred, Lynall, Mary-Ellen, Maurice, Christina, O'Donnell, Ciara, Pointon, Linda, St George Hyslop, Peter, Turner, Lorinda, Vertes, Petra, Widmer, Barry, Williams, Guy, Cavanagh, Jonathan, McColl, Alison, Shaw, Robin, Boddeke, Erik, Baird, Alison, Clare, Stuart, Cowen, Phil, Huang, I-Shu (Dante), Hurley, Sam, Lovestone, Simon, Nevado-Holgado, Alejo, Ribe, Elena, Vyas, Anviti, Winchester, Laura, Cleal, Madeleine, Gomez-Nicola, Diego, Mancuso, Renzo, Perry, Hugh, Cercignani, Mara, Clarke, Charlotte, Colasanti, Alessandro, Harrison, Neil, Murray, Rosemary, O'Connor, Jason, Mount, Howard, Schubert, Julia J., Fryer, Tim D., Manavaki, Roido, Kitzbichler, Manfred G., Nettis, Maria A., Pariante, Carmine M., Bullmore, Edward T., and Turkheimer, Federico E.

Published
2021
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35. Online singing interventions for postnatal depression in times of social isolation: a feasibility study protocol for the SHAPER-PNDO single-arm trial

Author

Bind, Rebecca H., Estevao, Carolina, Fancourt, Daisy, Hazelgrove, Katie, Sawyer, Kristi, Rebecchini, Lavinia, Miller, Celeste, Dazzan, Paola, Sevdalis, Nick, Woods, Anthony, Crane, Nikki, Manoharan, Manonmani, Burton, Alexandra, Dye, Hannah, Osborn, Tim, Greenwood, Lorna, Bakolis, Ioannis, Lopez, Maria Baldellou, Davis, Rachel, Perkins, Rosie, and Pariante, Carmine M.

Published
2022
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37. Women with depression in pregnancy or a history of depression have decreased quality of mentalization in the speech to their infants.

Author

Rebecchini, Lavinia, Bind, Rebecca H., Allegri, Beatrice, Zamparelli, Arianna, Biaggi, Alessandra, Hazelgrove, Katie, Osborne, Sarah, Conroy, Susan, Pawlby, Susan, Sethna, Vaheshta, and Pariante, Carmine M.

Subjects
DEPRESSION in women, MENTAL depression, POSTPARTUM depression, SPEECH disorders, COGNITIVE bias, ATTENTIONAL bias, PRENATAL depression
Abstract

Background: Our study aims to understand whether depression, either in pregnancy or lifetime, affects cognitive biases (comprising the attentional focus and affective state) and mentalizing features (ability to understand children's internal mental states, thereby detecting and comprehending their behavior and intention), in maternal speech during mother‐infant interaction in the first postnatal year. Methods: We recruited 115 pregnant women (44 healthy, 46 with major depressive disorder [MDD] in pregnancy, and 25 with a history of MDD but healthy pregnancy) at 25 weeks' gestation. Three‐minute videos were recorded at 8 weeks and 12 months postnatally for each dyad. Maternal speech was transcribed verbatim and coded for cognitive biases and mentalizing comments using the Parental Cognitive Attributions and Mentalization Scale (PCAMs). Results: Women suffering from antenatal depression showed a decreased proportion of mentalizing comments compared with healthy women, at both 8 weeks (0.03 ± 0.01 vs. 0.07 ± 0.01, P = 0.002) and 12 months (0.02 ± 0.01 vs. 0.04 ± 0.01, P = 0.043). Moreover, compared with healthy women, both those with antenatal depression and those with a history of depression showed decreased positive affection in speech (0.13 ± 0.01 vs. 0.07 ± 0.01 and 0.08 ± 0.02, respectively P = 0.003 and P = 0.043), and made significantly fewer comments focused on their infants' experience at 8 weeks (0.67 ± 0.03 vs. 0.53 ± 0.04 and 0.49 ± 0.05, respectively P = 0.015 and P = 0.005). In linear regression models women's socioeconomic difficulties and anxiety in pregnancy contribute to these associations, while postnatal depression did not. Conclusions: Both antenatal depression and a lifetime history of depression are associated with a decreased quality of women's speech to their infants, as shown by less focus on their infant's experience, decreased positive affection, and less able to mentalize. Examining maternal speech to their infants in the early postnatal months may be particularly relevant to identify women who could benefit from strategies addressing these aspects of the interactive behavior and thus improve infant outcome in the context of depression. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood

Author

Marzi, Sarah J, Sugden, Karen, Arseneault, Louise, Belsky, Daniel W, Burrage, Joe, Corcoran, David L, Danese, Andrea, Fisher, Helen L, Hannon, Eilis, Moffitt, Terrie E, Odgers, Candice L, Pariante, Carmine, Poulton, Richie, Williams, Benjamin S, Wong, Chloe CY, Mill, Jonathan, and Caspi, Avshalom

Subjects
Mental Health, Pediatric, Basic Behavioral and Social Science, Genetics, Violence Research, Prevention, Behavioral and Social Science, Violence Against Women, Youth Violence, Human Genome, 2.3 Psychological, social and economic factors, Aetiology, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Mental health, Peace, Justice and Strong Institutions, Adolescent, Age Factors, Child, Child Abuse, Child, Preschool, Crime Victims, DNA Methylation, Epigenesis, Genetic, Genes, Humans, Longitudinal Studies, Stress, Psychological, Epigenetics, Maltreatment, Stress, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

ObjectiveDNA methylation has been proposed as an epigenetic mechanism by which early-life experiences become "embedded" in the genome and alter transcriptional processes to compromise health. The authors sought to investigate whether early-life victimization stress is associated with genome-wide DNA methylation.MethodThe authors tested the hypothesis that victimization is associated with DNA methylation in the Environmental Risk (E-Risk) Longitudinal Study, a nationally representative 1994-1995 birth cohort of 2,232 twins born in England and Wales and assessed at ages 5, 7, 10, 12, and 18 years. Multiple forms of victimization were ascertained in childhood and adolescence (including physical, sexual, and emotional abuse; neglect; exposure to intimate-partner violence; bullying; cyber-victimization; and crime).ResultsEpigenome-wide analyses of polyvictimization across childhood and adolescence revealed few significant associations with DNA methylation in peripheral blood at age 18, but these analyses were confounded by tobacco smoking and/or did not survive co-twin control tests. Secondary analyses of specific forms of victimization revealed sparse associations with DNA methylation that did not replicate across different operationalizations of the same putative victimization experience. Hypothesis-driven analyses of six candidate genes in the stress response (NR3C1, FKBP5, BDNF, AVP, CRHR1, SLC6A4) did not reveal predicted associations with DNA methylation in probes annotated to these genes.ConclusionsFindings from this epidemiological analysis of the epigenetic effects of early-life stress do not support the hypothesis of robust changes in DNA methylation in victimized young people. We need to come to terms with the possibility that epigenetic epidemiology is not yet well matched to experimental, nonhuman models in uncovering the biological embedding of stress.

Published
2018

43. A qualitative exploration of active ingredients and mechanisms of action of an online singing programme with mothers experiencing postnatal depression during the COVID-19 pandemic: SHAPER-PNDO study.

Author

Burton, Alexandra, primary, Bind, Rebecca H., additional, Davis, Rachel, additional, Greenwood, Lorna, additional, Lee, Ching Yin, additional, Estevao, Carolina, additional, Hazelgrove, Katie, additional, Miller, Celeste, additional, Priestley, Kristi, additional, Rebecchini, Lavinia, additional, Osborn, Tim, additional, Dye, Hannah, additional, Dazzan, Paola, additional, Woods, Anthony, additional, Crane, Nikki, additional, Pariante, Carmine M., additional, and Fancourt, Daisy, additional

Published
2024
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44. Effects of a four-strain probiotic on inflammatory markers in Parkinson’s disease: a multicentre randomised controlled trial (the SymPD study) (N5.001)

Author

Leta, Valentina, primary, Mandal, Gargi, additional, Zinzalias, Pavlos, additional, Staunton, Juliet, additional, Batzu, Lucia, additional, Trivedi, Dhaval, additional, Rosqvist, Kristina, additional, Timpka, Jonathan, additional, van Vliet, Trinette, additional, Podlewska, Aleksandra, additional, Parry, Miriam, additional, van Wamelen, Daniel, additional, Rizos, Alexandra, additional, Chung-Faye, Guy, additional, Odin, Per, additional, Pariante, Carmine, additional, Borsini, Alessandra, additional, and Chaudhuri, K Ray, additional

Published
2024
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45. The PD-Ballet Study: A World First Randomised Controlled, Single-blinded, Diversity-enabled Trial of Dance Therapy for Parkinson’s (P9-3.002)

Author

Podlewska, Aleksandra, primary, Batzu, Lucia, additional, Staunton, Juliet, additional, Tall, Phoebe, additional, Leta, Valentina, additional, Rizos, Alexandra, additional, Derbyshire-Fox, Fleur, additional, Hartley, Alison, additional, Soukup, Tayana, additional, Sevdalis, Nick, additional, Crane, Nikki, additional, Healy, Andy, additional, Bakolis, Ioannis, additional, Pariante, Carmine, additional, Woods, Anthony, additional, and Chaudhuri, K Ray, additional

Published
2024
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