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Hot air drying is the key link of bulk grain and agricultural product processing. Because of the adjustment of national environmental protection and energy utilization policies in the new era, it is required to research and develop the energy saving technology of hot air drying for agricultural product. The current research is mostly limited to practical work tracking and empirical design, and there are also numerical calculations by heat and mass transfer theory. However these approaches have some limitations. Physical simulation is an effective potential method. In the process of studying the condensation increasing efficiency and energy saving technology, this paper has developed a test system which can simulate the actual hot air drying recycling energy. It has multi-parameter adjustable, graphical display drying state, energy consumption monitoring and other functions, and it can also provide effective means to study energy saving technology of hot air drying of agricultural product. The corn drying test for this system showed that energy recycling energy-saving drying could save energy 32%~56% when compared with ordinary open hot air drying.

Objective To summarize the characteristics of neural oscillation during the working memory maintenance in patients with left temporal lobe epilepsy (LTLE), and to explore the changes of neural oscillations in working memory disorders. Methods A total of 21 patients with LTLE (LTLE group) admitted to Tianjin Medical University General Hospital from September 2017 to May 2021 and 35 healthy controls (control group) with matched gender, age, education and cognitive function were enrolled. The visual working memory test was performed, response time and accuracy were recorded. Thirty-four channels of EEG signals were collected to calculate the power spectral density (PSD) of each frequency band during working memory maintenance. The PSD and spatial distribution of dominant frequency bands during working memory maintenance were compared between 2 groups. Results Compared with the control group, LTLE group had longer response time (t = 3.597, P = 0.001) and lower accuracy (t = 3.770, P = 0.001). θ frequency band was the dominant band during working memory maintenance, and the PSD of θ frequency band was mainly concentrated in the frontal region, especially the Fz channel of frontal midline. Compared with the control group, the PWM of θ frequency band of the whole brain (t = 2.600, P = 0.012), frontal region (t = 2.252, P = 0.029) and Fz channel (t = 2.496, P = 0.029) in LTLE group decreased. Conclusions LTLE patients with working memory disorders, and decreased θ oscillation during working memory may be a sensitive indicator of working memory disorders in patients with temporal lobe epilepsy.

Objective To investigate the expression of Toll - like receptor 4 (TLR4) protein in hippocampus of rat model with temporal lobe epilepsy after status epilepticus (SE) and explore its function in the pathogenesis of temporal lobe epilepsy. Methods Rat model with temporal lobe epilepsy was induced by lithium chloride (LiCl)-pilocarpine. Total protein was extracted from hippocampus and rat brain slices were obtained at different time points (0, 1, 6, 12, 24, 48 h and 7, 10, 30, 50 d) after SE. Western blotting and immunohistochemical staining were used for detection of the expression of TLR4 in the hippocampus. Results The results of Western blotting showed the TLR4 protein expression at 0, 1, 6, 12, 24, 48 h and 7, 10, 30 d after SE was higher than that in the control group (P < 0.05, for all), and the TLR4 protein expression at 50 d after SE showed no significant difference compared with the control group (P = 0.714). There was no significant difference between LiCl group and control group (P = 0.590). The results of immunohistochemistry showed the number of TLR4 positive neuron in CA3 area at 1, 6, 12, 24, 48 h and 7, 10, 30, 50 d after SE was higher than that in the control group (P < 0.05, for all), but showed no significant difference at 0 h after SE (P = 0.326). There was no significant difference between LiCl group and model group at 0 h after SE (P = 0.451). The difference in CA1 and CA2 area in different groups was not statistically significant (P > 0.05). Conclusion TLR4 protein was mainly expressed in cytoplasm of pyramidal cells in CA3 area of hippocampus. TLR4 protein expression in the hippocampus was increased in varying degrees at different observation time points after SE, indicating that TLR4 may play an important role in the development of epilepsy [ABSTRACT FROM AUTHOR]

Objective: To compare the measurements of glomerular filtration rate (GFR) determined by 99mTc-diethylene triamine pentaacetic acid (99mTc-DTPA) renal dynamic imaging with those estimated by Chronic Kidney Disease Epidemiology Collaboration (CDK-EPI) equation and to identify a more accurate measurement of GFR of chronic kidney disease (CKD) patients in clinical practice. Methods: The GFR was determined simultaneously by 3 methods: (a) dual plasma sample clearance method (tGFR); (b) renal dynamic imaging method (dGFR); (c) CDK-EPI equation (eGFR). The tGFR was employed as the reference method. The correlation, regression, and limit of agreement of dGFR and eGFR were used to demonstrate the validity of the two methods. The comparison of bias, precision, and accuracy between dGFR and eGFR was analyzed to identify the most suitable method. The analysis of bias, precision and accuracy was repeated after stratifying patients by a measured tGFR cutpoint of 60 ml·min−1·(1.73 m2)−1. Results: A total of 149 patients were enrolled. Both dGFR and eGFR correlated well with tGFR and the regression equation of dGFR and eGFR against tGFR was respectively Y = −4.289+0.962X (r = 0.919; RMSE = 14.323 ml.min−1. (1.73 m2)−1; P<0.001) and Y = 2.462+0.914X (r = 0.909; RMSE = 15.123 ml.min−1. (1.73 m2)−1; P<0.001). In addition, Bland-Altman analysis showed preferable agreement between the two methods and the reference method. The comparison revealed that eGFR, compared with dGFR, showed better performance on bias and 50% accuracy and similar performance on other indexes in the whole cohort and the lower-GFR subgroup, whereas in the higher-GFR subgroup the difference of the two methods was not significant in all parameters. Conclusions: Although both CDK-EPI equation and renal dynamic imaging can be used to determine the GFR of CKD patients, CDK-EPI equation is more accurate than renal dynamic imaging. As a result, 99mTc-DTPA renal dynamic imaging may be unsuitable to be used as the reference method in investigating the validity of CDK-EPI equation. [ABSTRACT FROM AUTHOR]

Jiang Meng-lin's liberal ideology, emphasizing individual freedom, rights, equality, and independence, fully affirms the self-realization and self-development value of the personality, promotes the compound innovation theory in the culture and advocates a gradual and peaceful approach to land reform. Jiang Meng-lin's liberal ideology provides the later generations with a valuable ideological and cultural heritage. [ABSTRACT FROM AUTHOR]

Objective: To observe the efficacy of umbilical cord mesenchymal stem cells (UC-MSCs) transplantation for the patients with refractory systemic lupus erythematosus (SLE)., Methods: Thirty seven patients with SLE were enrolled in this study, and divided into conventional treatment group (control group, n = 20) and UC-MSCS adjuvant treatment group (treatment group, n= 17). All the patients in both two groups were treated with glucocorticoids and cyclophosphamide (CTX). In the UC-MSCs group, each patient additionally received the transplantation of 3 x 10(7) UC-MSCs infusion intravenously. The clinical manifestations and laboratory parameters of each patient were observed before the treatments and 2 weeks, 1 month, 2 months, 3 months, months,9 months and 12 months after the treatments., Results: All the 37 patients were observed for 12 months. 24 h urinary protein excretion (U-Pro), anti nuclear antibody (ANA), erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hs-CRP), systemic lupus erythematosus disease activity index (SLEDAI) of these two groups decreased significantly (P < 0.05). serum albumin (ALB), C3, and C4 of two groups were higher after the treatments (P < 0.05). ALB and C3 in treatment group exceeded the control group (P < 0.05). The positive rates of Anti-dsDNA in control and treatment group were 40% and 10% respectively, while the recurrence rates were 50% and 20% respectively, these difference between the two groups were statistically significant (P < 0.05). There were no transplantation related complications observed., Conclusion: UC-MSCs transplantation could be effective and safe for refractory SLE on basis of glucocorticoid and cyclophosphamide therapy.

Objective: To study the effect of Panax notoginseng saponins (PNS) on cell proliferation, type I collagen secretion and integrin beta 1 expression in human kidney fibroblast (KFB)., Methods: KFB were cultured and stimulated by PNS in vitro. The cell proliferation, type I collagen secretion and integrin beta 1 expression in KFB were measured by methyl thiazolyl tetrazolium (MTT), enzyme-linked immunoabsorbent assay (ELISA) and flowcytometry respectively., Results: Within its optimal concentration range and effective time range, PNS could obviously inhibit the proliferation, type I collagen secretion and integrin beta 1 expression (all P < 0.05) in human KFB., Conclusion: PNS would possibly be an effective drug for renal interstitial fibrosis prevention and treatment.