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1. Clinical bacteriology in low-resource settings: today's solutions

Author

LUNGUYA, Octavie, PHOBA, Marie-France, LOMPO, Palpouguini, PHE, Thong, KARIUKI, Samuel, NEWTON, Paul N, DANCE, David A B, MUVUNYI, Claude, EL SAFI, Sayda, BARBE, Barbara, FALAY, Dadi, AFFOLABI, Dissou, PAGE, Maurice, LANGENDORF, Céline, GILLE, Yves, LEENSTRA, Tjalling, STELLING, John, NAAS, Thierry, KESTEMAN, Thomas, SEIFU, Daniel, DELAROCQUE-ASTAGNEAU, Elisabeth, SCHULTSZ, Constance, SCHUTT-GEROWITT, Heidi, LETCHFORD, Joanne, WERTHEIM, Heiman, KAHLMETER, Gunnar, AIDARA KANE, Awa, Ombelet, Sien, Ronat, Jean-Baptiste, Walsh, Timothy, Yansouni, Cedric P, Cox, Janneke, Vlieghe, Erika, Martiny, Delphine, Semret, Makeda, Vandenberg, Olivier, and Jacobs, Jan

Published
2018
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3. Clinical bacteriology in low-resource settings: today's solutions

Author

Ombelet, Sien, primary, Ronat, Jean-Baptiste, additional, Walsh, Timothy, additional, Yansouni, Cedric P, additional, Cox, Janneke, additional, Vlieghe, Erika, additional, Martiny, Delphine, additional, Semret, Makeda, additional, Vandenberg, Olivier, additional, Jacobs, Jan, additional, LUNGUYA, Octavie, additional, PHOBA, Marie-France, additional, LOMPO, Palpouguini, additional, PHE, Thong, additional, KARIUKI, Samuel, additional, NEWTON, Paul N, additional, DANCE, David A B, additional, MUVUNYI, Claude, additional, EL SAFI, Sayda, additional, BARBE, Barbara, additional, FALAY, Dadi, additional, AFFOLABI, Dissou, additional, PAGE, Maurice, additional, LANGENDORF, Céline, additional, GILLE, Yves, additional, LEENSTRA, Tjalling, additional, STELLING, John, additional, NAAS, Thierry, additional, KESTEMAN, Thomas, additional, SEIFU, Daniel, additional, DELAROCQUE-ASTAGNEAU, Elisabeth, additional, SCHULTSZ, Constance, additional, SCHUTT-GEROWITT, Heidi, additional, LETCHFORD, Joanne, additional, WERTHEIM, Heiman, additional, KAHLMETER, Gunnar, additional, and AIDARA KANE, Awa, additional

Published
2018
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4. Clinical bacteriology in low-resource settings: today's solutions

Author

Ombelet, Sien, Ronat, Jean Baptiste, Walsh, Timothy T.S., Yansouni, Cedric C.P., Cox, Janneke, Vlieghe, Erika, Martiny, Delphine, Semret, Makeda, Vandenberg, Olivier, Jacobs, Jan Adriaan J., Lunguya, Octavie, Phoba, Marie France, Lompo, Palpouguini, PHE, Thong, KARIUKI, Samuel, NEWTON, Paul P.N., Dance, David Allan Brett, MUVUNYI, Claude, EL SAFI, Sayda, BARBE, Barbara, Falay, Dadi, AFFOLABI, Dissou, PAGE, Maurice, LANGENDORF, Céline, GILLE, Yves, LEENSTRA, Tjalling, STELLING, John, Naas, Thierry, KESTEMAN, Thomas, SEIFU, Daniel, DELAROCQUE-ASTAGNEAU, Elisabeth, SCHULTSZ, Constance, SCHUTT-GEROWITT, Heidi, LETCHFORD, Joanne, WERTHEIM, Heiman, Kahlmeter, Gunnar, AIDARA KANE, Awa, Ombelet, Sien, Ronat, Jean Baptiste, Walsh, Timothy T.S., Yansouni, Cedric C.P., Cox, Janneke, Vlieghe, Erika, Martiny, Delphine, Semret, Makeda, Vandenberg, Olivier, Jacobs, Jan Adriaan J., Lunguya, Octavie, Phoba, Marie France, Lompo, Palpouguini, PHE, Thong, KARIUKI, Samuel, NEWTON, Paul P.N., Dance, David Allan Brett, MUVUNYI, Claude, EL SAFI, Sayda, BARBE, Barbara, Falay, Dadi, AFFOLABI, Dissou, PAGE, Maurice, LANGENDORF, Céline, GILLE, Yves, LEENSTRA, Tjalling, STELLING, John, Naas, Thierry, KESTEMAN, Thomas, SEIFU, Daniel, DELAROCQUE-ASTAGNEAU, Elisabeth, SCHULTSZ, Constance, SCHUTT-GEROWITT, Heidi, LETCHFORD, Joanne, WERTHEIM, Heiman, Kahlmeter, Gunnar, and AIDARA KANE, Awa

Abstract

Low-resource settings are disproportionately burdened by infectious diseases and antimicrobial resistance. Good quality clinical bacteriology through a well functioning reference laboratory network is necessary for effective resistance control, but low-resource settings face infrastructural, technical, and behavioural challenges in the implementation of clinical bacteriology. In this Personal View, we explore what constitutes successful implementation of clinical bacteriology in low-resource settings and describe a framework for implementation that is suitable for general referral hospitals in low-income and middle-income countries with a moderate infrastructure. Most microbiological techniques and equipment are not developed for the specific needs of such settings. Pending the arrival of a new generation diagnostics for these settings, we suggest focus on improving, adapting, and implementing conventional, culture-based techniques. Priorities in low-resource settings include harmonised, quality assured, and tropicalised equipment, consumables, and techniques, and rationalised bacterial identification and testing for antimicrobial resistance. Diagnostics should be integrated into clinical care and patient management; clinically relevant specimens must be appropriately selected and prioritised. Open-access training materials and information management tools should be developed. Also important is the need for onsite validation and field adoption of diagnostics in low-resource settings, with considerable shortening of the time between development and implementation of diagnostics. We argue that the implementation of clinical bacteriology in low-resource settings improves patient management, provides valuable surveillance for local antibiotic treatment guidelines and national policies, and supports containment of antimicrobial resistance and the prevention and control of hospital-acquired infections., SCOPUS: re.j, info:eu-repo/semantics/published

Published
2018

12. W H Collier Ltd 150 years of handmade bricks.

Author

Page, Maurice

Subjects
ANNIVERSARIES, BRICK industry
Abstract

The article announces the 150th anniversary celebration of handmade brick maker W. H. Collier Ltd. in Essex, England.

Published
2013

13. Postlaparotomy pain management: Comparison of patient-controlled analgesia pump alone, with subcutaneous bupivacaine infusion, or with injection of liposomal bupivacaine suspension.

Author

Yalmanchili HM, Buchanan SN, Chambers LW, Thorns JD, McKenzie NA, Reiss AD, Page MP, Dizon VV, Brooks SE, Shaffer LE, Lovald ST, Hartranft TH, and Price PD

Subjects
Analgesics, Opioid administration & dosage, Anesthetics, Local, Humans, Injections methods, Laparotomy, Liposomes, Pain Measurement, Prospective Studies, Analgesia, Patient-Controlled, Bupivacaine administration & dosage, Pain, Postoperative prevention & control
Abstract

Objective: Efforts to achieve balance between effective pain management and opioid-related adverse events (ORAEs) have led to multimodal analgesia regimens. This study compared opioids delivered via patient-controlled analgesia (PCA) plus liposomal bupivacaine, a long-acting local anesthetic with potential to be an effective component of such regimens, to opioids delivered through PCA alone or PCA plus subcutaneous bupivacaine infusion (ONQ), following laparotomy., Design: Prospective, randomized controlled trial., Setting: Single, tertiary-care institution., Patients: One hundred patients undergoing nonemergent laparotomy., Interventions: Patients were randomly assigned to one of three study treatments: PCA only (PCAO), PCA with ONQ, or PCA with injectable liposomal bupivacaine suspension (EXP)., Main Outcome Measures: Cumulative opioid use, daily mean patient-reported pain scores, and ORAEs through 72 hours postoperatively., Results: On average, the EXP (n = 31) group exhibited less than 50 percent of the total opioid consumption of the PCAO (n = 36) group, and less than 60 percent of that for the ONQ (n = 33) group. Postoperative days 1 and 3 pain scores were significantly lower for the EXP group as compared to the ONQ and PCAO groups (p ≤ 0.005). Fewer patients in the EXP group (19.4 percent) experienced ORAEs compared to the PCAO (41.1 percent) and ONQ (45.5 percent) groups (p = 0.002)., Conclusions: Laparotomy patients treated with liposomal bupivacaine as part of a multimodal regimen consumed less opioids, had lower pain scores, and had fewer ORAEs. The role of liposomal bupivacaine in the postoperative care of laparotomy patients merits further study.

Published
2019
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