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1. A change of IL-2 and IL-4 production in patients with Helicobactor pylori infection

Author: X. G. Fan, J. Yakoob, X. J. Fan, and P. W. N. Keeling
Subjects: Pathology, RB1-214
Abstract: Helicobactor pylori is the most common cause of gastroduodenal inflammation. However, the exact immune pathogenesis is not fully understood. To look for evidence of the immunological mechanism in H. pylori associated disease, we measured cytokine interleukin-2 (IL-2) and IL-4 levels produced by peripheral blood lymphocytes (PBL) and gastric biopsies in 20 subjects with or without H. pylori infection. H. pylori can stimulate IL-2 and IL-4 production from PBL in H. pylori negative as well as H. pylori positive individuals. The spontaneous IL-2 production by PBL and gastric biopsies was greater (p < 0.0025,
Published: 1995
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2. Evidence of an enhanced central 5HT response in irritable bowel syndrome and in the rat maternal separation model

Author: P. W. N. Keeling, Gerard Clarke, Siobhain M. O'Mahony, Timothy G. Dinan, Eamonn Martin Quigley, Fergus Shanahan, and A. S B Chua
Subjects: Adult, Male, Serotonin, medicine.medical_specialty, Adolescent, Physiology, Buspirone, Irritable Bowel Syndrome, Rats, Sprague-Dawley, Random Allocation, Internal medicine, medicine, Animals, Humans, Pindolol, 5-HT receptor, Serotonin transporter, Irritable bowel syndrome, biology, Endocrine and Autonomic Systems, Maternal Deprivation, Gastroenterology, Antagonist, Middle Aged, medicine.disease, Prolactin, Rats, Disease Models, Animal, Endocrinology, Animals, Newborn, biology.protein, Female, Psychology, medicine.drug
Abstract: Efforts to define either a biomarker for irritable bowel syndrome (IBS) or a valid animal model have proven disappointing. The aims of this study were to determine if buspirone stimulates prolactin release through the 5-hydroxytryptamine (5HT)1a receptor and whether this response is altered in patients with IBS and in the rat maternal separation model. Buspirone (30 mg) was used to stimulate prolactin release in 40 patients with IBS and in 40 healthy controls. In study 1, 10 IBS patients and 10 controls underwent pretreatment with pindolol (5HT1a antagonist) or placebo followed by buspirone. In study 2, 30 patients with IBS and 30 healthy controls had prolactin release stimulated by buspirone. Maternally separated and nonseparated rats were also treated with buspirone and prolactin monitored. Serotonin metabolites were measured together with the expression of the 5HT1a and serotonin transporter (SERT) gene. Pindolol produced a dose-dependent decrease in the buspirone prolactin response. Patients with IBS and maternally separated rats showed an exaggerated release of prolactin in response to buspirone. In the animal model, an increased turnover of 5HT was found in the brainstem together with a trend toward increased activity of the SERT gene. In conclusion altered central serotonin responses are found in both IBS and in an animal model.
Published: 2008
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3. Review: lipoxygenase inhibitors and the gut

Author: P. W. N. Keeling and Nicholas P. Kennedy
Subjects: Hepatitis, Leukotrienes, Hepatology, Gastrointestinal Diseases, Eicosanoid metabolism, business.industry, Metabolite, Gastroenterology, Inflammation, Disease, Pharmacology, medicine.disease, In vitro, chemistry.chemical_compound, Lipoxygenase Inhibitors, Mesalazine, chemistry, Animals, Humans, Medicine, Pharmacology (medical), medicine.symptom, business
Abstract: SUMMARY Leukotriene synthesis is influenced by several drugs currently in use for the treatment of alimentary disease, including the corticosteroids, sulphasalazine and mesalazine. However, the use of selective lipoxygenase inhibitors in human gastrointestinal disease has not been investigated. The complexity of eicosanoid metabolism, and the incomplete knowledge of roles played by each metabolite in each tissue and disease condition, make rational pharmacological manipulation of arachidonate metabolism difficult. However, lipoxygenase inhibitors show promise in animal models of inflammation, including hepatitis, and studies in vitro suggest that therapeutic benefits may be achieved using inhibitors of leukotriene synthesis in other inflammatory disorders.
Published: 2007
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4. Proinflammatory Cytokine and Nuclear Factor Kappa-B Expression along the Inflammation-Metaplasia-Dysplasia-Adenocarcinoma Sequence in the Esophagus

Author: James M. O’Riordan, P. W. N. Keeling, John V. Reynolds, Patrick J. Byrne, Mohamed M.M. Abdel-Latif, Dermot Kelleher, Deirdre McNamara, N Ravi, and George S.A. McDonald
Subjects: Electrophoresis, Male, Pathology, medicine.medical_specialty, Esophageal Neoplasms, Biopsy, medicine.medical_treatment, Enzyme-Linked Immunosorbent Assay, Adenocarcinoma, Proinflammatory cytokine, Barrett Esophagus, Intestinal mucosa, Metaplasia, medicine, Esophagitis, Humans, Endoscopy, Digestive System, Prospective Studies, Intestinal Mucosa, Hepatology, business.industry, Esophageal disease, Interleukin-8, NF-kappa B, Gastroenterology, Intestinal metaplasia, Middle Aged, medicine.disease, digestive system diseases, Cytokine, Dysplasia, Gastroesophageal Reflux, Female, medicine.symptom, business, Precancerous Conditions, Biomarkers, Interleukin-1
Abstract: The incidence of esophageal adenocarcinoma has increased significantly in the western world over the last 20 yr. Most cases arise in a background of chronic gastroesophageal reflux, and specialized intestinal metaplasia in Barrett's esophagus is frequently an antecedent phenotype or evident in association with adenocarcinoma. The molecular events that characterize the pathway from inflammation to metaplasia to dysplasia and adenocarcinoma are poorly understood.To examine the expression of the proinflammatory cytokines IL-8 and IL-1beta along the esophagitis, metaplasia, dysplasia, and adenocarcinoma pathway, and to correlate this with histological changes and expression of the transcription factor NF-kappaB.Fresh biopsy specimens were collected from patients with reflux esophagitis (n=15), Barrett's esophagus (n=35), Barrett's adjacent to adenocarcinoma (n=8), and esophageal adenocarcinoma (n=35). IL-8 and IL-1beta expression were measured using enzyme-linked immunosorbent assay. NF-kappaB expression was measured by electrophoretic mobility shift assay.Elevated expression of NF-kappaB was found in 2 (13%) out of 15 patients with reflux esophagitis, 21 (60%) out of 35 patients with Barrett's esophagus, and 28 (80%) out of 35 patients with esophageal adenocarcinoma. All 5 patients with Barrett's esophagus and high-grade dysplasia showed elevated expression of NF-kappaB. IL-8 and IL-1beta were significantly increased in esophagitis, Barrett's, and adenocarcinoma compared with squamous epithelium, and in adenocarcinoma compared with all other groups. There was a stepwise increase in the expression of IL-8, IL-1beta, and NF-kappaB from normal through Barrett's epithelium to adenocarcinoma in eight cases of esophageal adenocarcinoma. The levels of both IL-8 and IL-1beta in adenocarcinoma patients correlated with stage of disease. Patients with adenocarcinoma who were NF-kappaB positive had significantly higher levels of both IL-8 (p=0.04) and IL-1beta (p=0.03) compared to adenocarcinoma patients who were NF-kappaB negative.The proinflammatory cytokines IL-8 and IL-1beta are elevated in esophagitis and Barrett's epithelium, and markedly elevated in adenocarcinoma. NF-kappaB activation is infrequent in esophagitis, but is increased in Barrett's epithelium and adenocarcinoma. The association of NF-kappaB activation with cytokine upregulation was only evident in patients with adenocarcinoma. These patterns may play an important role in Barrett's inflammation and tumourigenesis, and inhibition of the NF-kappaB/proinflammatory cytokine pathway may be an important target for future chemoprevention strategies.
Published: 2005
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5. Impaired visceral sensitivity to acid reflux in patients with Barrett’s esophagus. the role of esophageal motility*

Author: John V. Reynolds, Patrick J. Byrne, P. W. N. Keeling, E. D. Mulligan, and James M. O’Riordan
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, Motility, Distension, digestive system, Gastroenterology, Bile reflux, Barrett Esophagus, Esophagus, Internal medicine, medicine, Humans, Aged, Aged, 80 and over, business.industry, Reflux, General Medicine, Middle Aged, medicine.disease, digestive system diseases, medicine.anatomical_structure, Barrett's esophagus, Gastroesophageal Reflux, GERD, Female, Gastrointestinal Motility, business, Perfusion
Abstract: Patients with Barrett's esophagus have been reported to have impaired visceral sensitivity to acid perfusion and distension compared with non-Barrett's refluxers, but the mechanism is poorly understood. Esophageal motility and clearance mechanisms may be important, and this study explored the relationship of motility with symptoms. Seventy-four patients with Barrett's esophagus were compared with 216 patients with gastro-esophageal reflux disease (GERD) with abnormal acid reflux scores, and 50 symptomatic patients who had normal acid exposure. All patients had esophageal manometry and 24-h pH monitoring. Thirty-six Barrett's patients also had 24-h bile reflux monitoring. Symptoms were assessed by Symptom Index (SI) during 24-h pH monitoring. Barrett's patients with normal motility had a significantly lower SI than GERD patients for similar acid exposure (P < 0.001). Barrett's patients with abnormal motility had higher acid exposure than those with normal motility (P < 0.05), but the SI values for this group was not significantly different from the GERD patients. SI and Bile reflux in Barrett's esophagus was not significantly different in patients with normal or abnormal motility. Barrett's patients had less sensitivity than GERD patients for similar acid exposure. Normal motility in Barrett's esophagus is associated with the poorest sensitivity and the presence of increased acid exposure is required in order to achieve sensitivity levels comparable with GERD patients.
Published: 2003
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6. Altered hypothalamic cholinergic responses in patients with nonulcer dyspepsia: a study of pyridostigmine-stimulated growth hormone release

Author: Lucinda V. Scott, Deirdre McNamara, P. W. N. Keeling, Timothy G. Dinan, and D Brady
Subjects: Adult, Male, medicine.medical_specialty, Hypothalamus, Stimulation, Growth hormone, Helicobacter Infections, Internal medicine, medicine, Humans, In patient, Dyspepsia, Analysis of Variance, Chi-Square Distribution, Helicobacter pylori, Hepatology, business.industry, digestive, oral, and skin physiology, Gastroenterology, Middle Aged, digestive system diseases, Endocrinology, Follicular Phase, Pyridostigmine, Area Under Curve, Case-Control Studies, Growth Hormone, Cholinergic, Liberation, Female, Pyridostigmine Bromide, Cholinesterase Inhibitors, Secretory Rate, business, medicine.drug
Abstract: Acetylcholine plays a central and peripheral role in regulating gastric motility. In the hypothalamus, it is a key neuroendocrine modulator; acting through somatostatin, it brings about the release of growth hormone (GH). We measured hypothalamic cholinergic receptor sensitivity in patients with nonulcer dyspepsia (NUD) by examining GH release in response to cholinergic challenge.Forty patients with NUD and 40 healthy comparison subjects were administered pyridostigmine (the acetylcholinesterase inhibitor, 120 mg), and GH release over a 3-h period was monitored.Calculating response as the maximum GH relative to baseline (delta GH), the mean +/- SEM response in the patients was 11.9 +/- 1.9 U/L and in the healthy subjects 6.7 +/- 0.7 mU/L (t = 2.1, df = 78, p = 0.03). Helicobacter pylori status had no appreciable impact on GH response with H. pylori-positive patients having a mean response of 10.5 +/- 2.1 mU/L and negative patients a mean response of 13.2 +/- 3.4 mU/L. Overall, patients with NUD release more GH in response to pyridostigmine challenge than healthy subjects.Patients with NUD may have a pathophysiological disturbance involving central cholinergic systems.
Published: 2002
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7. Pituitary-Adrenal Response to Naloxone in Non-Ulcer Dyspepsia: Preliminary Evidence for a Reduction in Central Opioid Tone

Author: P. W. N. Keeling, Lucinda V. Scott, Timothy G. Dinan, and Omar Rathore
Subjects: Adult, Male, medicine.medical_specialty, Hydrocortisone, Narcotic Antagonists, Diagnostico diferencial, Pituitary-Adrenal System, (+)-Naloxone, Adrenocorticotropic hormone, Adrenocorticotropic Hormone, Internal medicine, Humans, Medicine, Dyspepsia, Morphinan derivatives, Naloxone, business.industry, Narcotic antagonist, digestive, oral, and skin physiology, Gastroenterology, digestive system diseases, Non ulcer dyspepsia, Endocrinology, Opioid, Case-Control Studies, Female, business, medicine.drug
Abstract: Background: Non-ulcer dyspepsia (NUD) is one of the core functional bowel disorders. There has been recent emphasis on possible abnormal brain-gut interactions as being central to its pathophysiology. In this preliminary study, we examined central opioid tone in Helicobacter pylori-negative NUD patients using naloxone, an opioid antagonist, which stimulates pituitary-adrenal activity. The opioid system is known to govern nociceptive processing and to play a role in gut motor activity. Subjects: Eight subjects with NUD and 8 age- and sex-matched healthy subjects were examined. Methods: Naloxone, 0.125 mg/kg, was administered at time 0. Adrenocorticotropin (ACTH) and cortisol responses were measured over a 120-min period. Maximum pituitary-adrenal responses in the 2 groups were compared. Results: The ACTH response was significantly attenuated in the NUD group (p < 0.05). The cortisol response did not differ between the 2 groups (p = 0.7). Conclusions: Central opioid tone may be reduced in subjects with NUD. Our preliminary findings suggest that altered opioidergic activity may contribute to NUD pathophysiology, influencing the symptom profile through altered gut motor activity or possibly by influencing visceral sensitivity.
Published: 2002
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8. A double-blind placebo-controlled study of buspirone-stimulated prolactin release in non-ulcer dyspepsia-are central serotoninergic responses enhanced?

Author: O. Rathore, Jorgen Naesdal, Lucinda V. Scott, P. W. N. Keeling, Nasir Mahmud, Jogin H. Thakore, Colm O'Morain, Timothy G. Dinan, and E. Carr
Subjects: medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, Placebo-controlled study, Placebo, Serotonergic, Partial agonist, digestive system diseases, Prolactin, Buspirone, law.invention, Endocrinology, Randomized controlled trial, law, Internal medicine, medicine, Pharmacology (medical), business, 5-HT receptor, medicine.drug
Abstract: Background: Dyspepsia is a common symptom for which an organic cause is found in only 40% of patients. When no cause is apparent and the dyspepsia is considered to be idiopathic, a diagnosis of non-ulcer dyspepsia is made. The pathophysiology of non-ulcer dyspepsia is poorly understood and numerous theories have been put forward, including a theory of enhanced central serotoninergic receptor sensitivity. Aim: To determine the sensitivity of serotonin receptors in non-ulcer dyspepsia. Methods: Using a randomized, double-blind, placebo-controlled design, we compared buspirone (a serotonin type 1a partial agonist)-stimulated prolactin release in 50 patients and 59 healthy comparison subjects. Buspirone, 30 mg, or matching placebo was administered on two separate occasions and prolactin release over 180 min was monitored. Patients and healthy subjects received both treatments in random order, 1 week apart. Results: Overall, patients with non-ulcer dyspepsia had greater prolactin release in response to the buspirone challenge than the healthy comparison subjects, with differences most significant at 90 min following the challenge. Enhancement occurred in patients both with and without Helicobacter pylori infection. Female subjects, both patients and healthy volunteers, showed a greater response to buspirone than male subjects, and the augmentation of response observed in male and female patients was greater in females. Conclusions: Patients with non-ulcer dyspepsia have enhanced central serotoninergic responses and such responses are independent of H. pylori infection. Blockade of such receptors might be an appropriate therapeutic strategy.
Published: 2001
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9. Potential Impact of Magnetic Resonance Cholangiopancreatography on Endoscopic Retrograde Cholangiopancreatography Workload and Complication Rate in Patients Referred Because of Abdominal Pain

Author: P. W. N. Keeling, M. M. Morrin, Nasir Mahmud, Dermot Kelleher, Richard J. Farrell, and N. Noonan
Subjects: medicine.medical_specialty, Abdominal pain, Digestive System Diseases, Contrast Media, Workload, digestive system, Clinical Protocols, medicine, Humans, In patient, Retrospective Studies, Cholangiopancreatography, Endoscopic Retrograde, Magnetic resonance cholangiopancreatography, Endoscopic retrograde cholangiopancreatography, medicine.diagnostic_test, business.industry, Gastroenterology, Retrospective cohort study, medicine.disease, Magnetic Resonance Imaging, digestive system diseases, Abdominal Pain, Surgery, surgical procedures, operative, medicine.anatomical_structure, Pancreatitis, Sphincter, Radiology, medicine.symptom, business
Abstract: Background and study aims Endoscopic retrograde cholangiopancreatography (ERCP) has a significant mortality, morbidity, and failed cannulation rate. Magnetic resonance cholangiopancreatography (MRCP) is a safer, noninvasive method of imaging the pancreaticobiliary tree. A substantial number of patients are referred for ERCP because of abdominal pain, a high proportion of whom have normal ducts or pathology not requiring interventional ERCP. The aim was to assess the potential impact of MRCP on overall ERCP workload and patient outcome if MRCP were the primary investigation in patients referred for ERCP because of abdominal pain. Patients and methods 1758 consecutive ERCPs performed in 1148 patients over a 3-year period in a single tertiary referral center in the pre-MRCP era were reviewed. Cannulation failure, ERCP findings, need for follow-up ERCP and all 30-day major complication rates were analyzed with regard to clinical indications. Results The overall workload comprised 1108 (63 %) successful initial ERCPs, 188 (11 %) failed cannulation attempts and 462 (26 %) follow-up ERCPs. Of the patients, 299 (27 %) had normal ERCP findings, 331 (30 %) had choledocholithiasis and 246 (22 %) had strictures. lf MRCP had been used as the primary imaging investigation in the 451 patients (39 %) referred for ERCP because of abdominal pain, we estimate that 197 patients (44 %) would have avoided ERCP, and the overall ERCP workload would have been reduced by 13 %. Initial MRCP in suspected gallstone pancreatitis and certain miscellaneous groups, it was estimated, would have further decreased ERCP workload by 9 %. Four of 40 major ERCP-related complications (3.5 %) and one of four ERCP-related deaths (0.35 %) would potentially have been avoided. Conclusions Initial MRCP in patients referred with abdominal pain would potentially have avoided ERCP in 44 % of cases, reduced ERCP workload by 13 % and significantly reduced patient morbidity and mortality. The relatively small reduction in ERCP workload among these patients reflects the fact that over half of them had probable sphincter dysfunction, a significant proportion of whom might have benefited from biliary manometry and/or endoscopic intervention despite a normal MRCP. Furthermore, a small number of patients with calculi and subtle biliary and pancreatic strictures would be missed by this approach.
Published: 2001
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10. Diagnostic and therapeutic ERCP: a large single centre’s experience

Author: N. Noonan, Dermot Kelleher, Nasir Mahmud, Richard J. Farrell, and P. W. N. Keeling
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, Bile Duct Diseases, digestive system, Humans, Medicine, Major complication, Aged, Retrospective Studies, Aged, 80 and over, Cholangiopancreatography, Endoscopic Retrograde, Endoscopic retrograde cholangiopancreatography, medicine.diagnostic_test, business.industry, Incidence (epidemiology), General surgery, Mortality rate, Retrospective cohort study, General Medicine, Middle Aged, digestive system diseases, Surgery, Single centre, surgical procedures, operative, Biliary sphincterotomy, Female, business, Complication
Abstract: Most large published series on endoscopic retrograde cholangiopancreatography (ERCP) are multicentrebased and consequently reflect varying experience. To assess morbidity and mortality rates of ERCP in a single tertiary referral centre. A series of 1,758 consecutive ERCPs performed in 1,148 patients between 1991 and 1994 were reviewed to evaluate indications, findings, procedures, success, complication and mortality rates. There were 1,108 (63%) successful initial ERCPs, 11% failed cannulation attempts and 26% follow-up ERCPs. The desired duct was successfully cannulated in 96.5% of cases. Initial cannulation failure rate was 8.8%. Twenty-seven per cent had normal ERCPs, 30% had choledocholithiasis and 22% had strictures. Fifty-five per cent had therapeutic ERCPs. Major complications occurred in 3.5% with four ERCP-related deaths (0.35%). Therapeutic ERCP had a higher incidence of major complications compared to diagnostic ERCP: 4.6% vs 2.1%, (p=0.02); and mortality rate was 0.5% vs 0.2%, (p=0.4). Significant haemorrhage secondary to biliary sphincterotomy, pre-cut papillotomy and snare papillectomy accounted for most of the difference (1.6%). The majority of ERCPs were performed in elderly patients, over half of whom required therapeutic ERCP. Therapeutic ERCP carried significantly higher complication rate compared with diagnostic ERCP. Unsuccessful cannulation and follow-up ERCP accounted for 11% and 26% of ERCP workload, respectively.
Published: 2001
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11. Randomized comparison of unfractionated heparin with corticosteroids in severe active inflammatory bowel disease

Author: Barry White, Nasir Mahmud, P. W. N. Keeling, M. Byrne, Owen P. Smith, Yeng Ang, G. S. A. Mcdonald, Mark Lawler, and Alan Kelly
Subjects: medicine.medical_specialty, Hepatology, Combination therapy, business.industry, medicine.drug_class, Anticoagulant, Gastroenterology, Heparin, medicine.disease, Inflammatory bowel disease, Ulcerative colitis, Surgery, Prednisone, Internal medicine, Prednisolone, Medicine, Pharmacology (medical), Colitis, business, medicine.drug
Abstract: Background: Heparin therapy may be effective in steroid resistant inflammatory bowel disease. Aim: A randomized pilot study, to compare unfractionated heparin as a first-line therapy with corticosteroids in colonic inflammatory bowel disease. Methods: Twenty patients with severe inflammatory bowel disease (ulcerative colitis, n=17; Crohn’s colitis, n=3) were randomized to either intravenous heparin for 5 days, followed by subcutaneous heparin for 5 weeks (n=8), or high-dose intravenous hydrocortisone for 5 days followed by oral prednisolone 40 mg daily, reducing by 5 mg per day each week (n=12). After 5 days, non-responders in each treatment group were commenced on combination therapy. Response to therapy was monitored by: clinical disease activity (ulcerative colitis: Truelove and Witt Index; Crohn’s colitis: Harvey and Bradshaw Index), stool frequency, serum C-reactive protein and α1 acid glycoprotein, endoscopic and histopathological grading. Results: The response rates were similar in both treatment groups: clinical activity index (heparin vs. steroid; 75% vs. 67%; P=0.23), stool frequency (75% vs. 67%; P=0.61), endoscopic (75% vs. 67%; P=0.4) and histopathological grading (63% vs. 50%; P=0.67). Both treatments were well-tolerated with no serious adverse events. Conclusion: Heparin as a first line therapy is as effective as corticosteroids in the treatment of colonic inflammatory bowel disease. Large multicentre randomized comparative studies are required to determine the role of heparin in the management of inflammatory bowel disease.
Published: 2000
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12. Lansoprazole is superior to ranitidine as maintenance treatment for the prevention of duodenal ulcer relapse

Author: D. G. Weir, R. P. H. Thompson, K D Bardhan, J. P. Crowe, P. W. N. Keeling, S. L. Crouch, and P. N. Trewby
Subjects: medicine.medical_specialty, Chemotherapy, Randomization, Hepatology, business.industry, medicine.drug_class, medicine.medical_treatment, Gastroenterology, Lansoprazole, Proton-pump inhibitor, Ranitidine, medicine.anatomical_structure, Maintenance therapy, Internal medicine, medicine, Duodenum, Pharmacology (medical), Adverse effect, business, medicine.drug
Abstract: Aim : To compare lansoprazole 30 mg once daily, lansoprazole 15 mg once daily and ranitidine 150 mg once nightly in the prevention of duodenal ulcer relapse in patients whose duodenal ulcers had been previously healed with lansoprazole 30 mg once daily or ranitidine 300 mg nightly. Methods : A double-blind, parallel group, randomized multicentre study conducted in 33 centres in the UK, Eire, Sweden and Australia. Two hundred and nineteen patients with a duodenal ulcer were randomized to receive lansoprazole 30 mg and 217 to receive ranitidine 300 mg for 8 weeks. Patients were then re-randomized to receive lansoprazole 30 mg (122 patients), lansoprazole 15 mg (121 patients) or ranitidine 150 mg (116 patients) for 12 months. All patients had an endoscopically-proven duodenal ulcer at baseline and were considered suitable for long-term maintenance therapy to prevent relapse. Results : Significantly more patients were healed on lansoprazole (98%) compared to ranitidine (89%) (P
Published: 1999
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13. Irish society of gastroenterology

Author: M. P. Curry, S. Norris, J. E. Hegarty, F. Smith, N. Nolan, L. Golden-Mason, C. O’Farrelly, K. M. Walsh, A. Fletcher, R. N. M. MacSween, A. J. Morris, A. Bohan, E. Ryan, A-M. Flanagan, P. Martinez-Dalmau, J. Crowe, J. Kelly, O. Traynor, J. Mathias, P. A. McCormick, G. McEntee, J. Hegarty, S. Barrett, J. C. O’Keane, A. A. Shah, M. Berry, B. Thjodleifsson, I. Bjarnason, H. Gudjohnsson, E. Oddson, D. J. Fitzgerald, E. Kay, A. Price, F. E. Murray, E. Carton, E. D. Mulligan, M. T. P. Caldwell, D. Rana, B. Ryan, N. Mahmud, N. Keeling, W. A. Tanner, F. B. V. Keane, G. McDonald, J. V. Reynolds, Z. Mahmood, O. Rathore, I. Ellis, P. Byrne, P. W. N. Keeling, I. Khan, K. McManus, V. Anikin, M. Mills, J. McGuigan, C. Taylor, D. C. Winter, G. C. O’Sullivan, B. J. Harvey, M. W. Bennett, J. O’Connell, J. K. Collins, F. Shanahan, P. Wieneke, C. O’Leary, M. Healy, T. O’Halloran, R. Barry, C. C. Cronin, P. O’Regan, H. O’Grady, D. Grant, K. Sheahan, J. M. P. Hyland, D. P. O’Donoghue, J. Murphy, G. Lee, M. Madden, P. Shanahan, G. O. Sullivan, H. Shima, R. Basisht, K. Ohshiro, P. Puri, J. Goh, P. MacMathuna, A. Baird, C. Godson, H. R. Brady, N. A. Petasis, V. V. Fokin, G. McCormack, K. Khosraviani, H. P. Weir, K. Williamson, P. Hamilton, R. J. Moorehead, J. Mcllmoyle, R. G. P. Watson, J. S. A. Collins, T. C. K. Tham, R. M. Doyle, C. Molony, D. Fitzpatrick, D. Coakley, J. B. Walsh, D. Kelleher, E. Devitt, C. Keane, C. Walsh, K. P. Murray, H. S. Kaufman, J. H. Shin, H. A. Pitt, S. D. Johnston, S. A. McMillan, C. J. Larkin, J. M. Sloan, J. E. S. Ardill, J. S. Collins, K. D. Buchanan, W. J. Curry, C. F. Johnston, W. Curry, C. Johnston, J. Sloan, J. Ardill, R. Irvine, L. Gibson, G. Creedon, M. Mabruk, M. Leader, T. O’Grady, M. Murphy, B. Harhen, A. Hickey, N. Gannon, C. O’Boyle, R. Byrne, M. Smith, F. Murray, M. F. Byrne, J. Quinlan, C. P. Delaney, R. Varadarajan, J. M. Hyland, P. M. MacEneaney, S. J. Skehan, M. Curry, R. G. Gibney, D. E. Malone, S. Kealy, J. Dodd, R. Murrary, D. P. Donoghue, D. Keating, Z. Hashim, J. Donnellan, Y. O’Connor, M. Kearns, F. M. Stevens, S. Sookhai, J. H. Wang, P. Neary, M. McCourt, D. O’Connell, H. P. Redmond, E. McAteer, W. J. Campbell, E. J. Mackle, C. Smyth, S. McKiernan, M. Lawlor, K. Pilkington, R. Hagan, S. Montague, M. Buckley, C. A. O. Morain, C. Connolly, S. Tierney, J. Gray, N. D. Lyons, P. V. Delaney, P. A. Grace, L. Nemeth, D. S. O’Briain, C. O’Toole, D. Roddy, M. Griffin, T. P. J. Hennessy, C. O’Keffe, D. O’Donoghue, E. Murphy, J. Reynolds, J. J. Nolan, M. McAndrew, G. Clarke, S. Stewart, A. Cockram, B. Coughlan, J. Sheehan, E. E. Lang, D. McNamara, H. Hamilton, S. Beattie, C. O’Morain, H. J. Windle, A. Heaney, W. S. Chan, R. M. S. Mitchell, L. Feighery, K. Quane, M. Molloy, C. Feighery, C. O. Farrelly, B. M. Egan, M. K. Barry, D. C. Grant, P. Barry, P. Casey, M. Laffoy, J. Tracey, T. Goode, A. Hopkins, A. W. Baird, M. Kingston, M. Blackwell, P. F. O’Regan, L. J. Maher, and M. M. Skelly
Subjects: medicine.medical_specialty, Irish, business.industry, Ophthalmology, language, Medicine, Library science, General Medicine, business, language.human_language
Published: 1998
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14. Irish society of gastroenterology

Author: B. M. Ryan, S. McKiernan, P. W. N. Keeling, P. J. Byrne, R. Quill, K. McCallion, R. M. S. Mitchell, R. G. P. Watson, J. S. A. Collins, K. R. Gardiner, D. C. Winter, G. C. O’Sullivan, C. T. Taylor, N. F. Fanning, H. P. Redmond, D. P. O’Donoghue, A. W. Baird, B. J. Harvey, A. E. Brannigan, P. R. O’Connell, M. C. Regan, J. M. Fitzpatrick, R. W. G. Watson, H. Lemass, E. Ryan, P. MacMathuna, J. Crowe, J. C. O’Keane, J. Goh, A. Baird, L. Maher, C. Godson, H. R. Brady, N. A. Petasis, V. V. Fokin, M. K. Barry, D. C. Grant, K. Sheahan, J. M. P. Hyland, K. M. Sheehan, D. J. Fitzgerald, F. E. Murray, A. Heaney, K. B. Bamford, R. J. McFarland, T. C. K. Tham, D. McNamara, S. Franelli, H. Whelan, H. Hamilton, S. Beattie, C. O’Morain, E. G. Brennan, N. O’Hare, R. McDermott, N. I. McDougall, C. M. Gieeson, S. E. H. Russell, J. M. Sloan, D. Morrisey, L. Murphy, B. Kiely, G. Fitzgerald, C. Daly, G. O’Sullivan, F. Shanahan, J. K. Collins, P. Marteau, S. D. Johnston, C. Coates, C. Feighery, J. O’Keeffe, A. Whelan, S. Lynch, D. G. Weir, M. Abuzakouk, L. Barnes, N. O’Gorman, M. McKenna, R. Freaney, M. Young, S. Gaines, D. Brady, D. Drudy, C. O’Farrelly, A. Gilleece, L. Fenelon, J. McPartlin, A. M. Hopkins, A. Myers, P. Moynagh, J. M. Kirby, M. J. Allen, B. Best, H. Calvert, S. Kirk, S. T. D. McKelvey, R. J. Moorehead, J. C. Varghese, S. Sookhai, T. Walsh, H. Osborne, P. Broe, M. J. Lee, D. Moriarty, R. Coffey, E. Murphy, A. A. Shah, E. Murray, B. Thjodleifsson, I. Bjarnason, S. Montague, C. Forkin, G. C. O’Toole, C. M. Gallagher, P. Connell, O. Traynor, T. C. Ling, B. Johnston, M. F. Byrne, M. A. Farrell, C. A. Goulding, S. S. Albloushi, P. O’Connell, L. E. Graham, T. J. Robinson, T. Jabeen, B. Cannon, D. Jenkins, M. J. Whelton, S. Bohra, C. Keohane, M. Duggan, R. K. Siddheshwar, R. G. Wilson, P. J. Hainsworth, F. C. Campbell, S. B. Kelly, B. M. Egan, C. Simutowe, D. A. McNamara, N. Collins, T. N. Walsh, A. Mukherjee, M. Scott, C. Pohl, E. Duggan, M. Wasi, A. Sarkar, L. O. Donnell, P. W. Eustace, J. G. Johnston, R. Waldron, S. Barrett, G. Callagy, J. C. O. Keane, B. Coughlan, J. Sheehan, A. Hickey, A. Carr, M. R. Kell, M. Lynch, D. Ryan, P. Rajpal, W. O. Kirwan, C. J. Larkin, J. E. S. Ardill, K. D. Buchanan, P. L. Lim, M. Gibbons, E. J. Crawford, B. T. Johnston, C. Rodgers, S. Johnston, B. M. Crone, A. H. G. Love, L. Feighery, J. Jackson, M. M. I. Yassin, D. W. Harkin, A. A. B. Barros D’sa, T. G. Parks, M. P. Curry, J. E. Hegarty, L. Golden-Mason, E. Hannigan, and N. Parfrey
Subjects: medicine.medical_specialty, Pediatrics, Irish, business.industry, Family medicine, medicine, language, General Medicine, business, language.human_language
Published: 1998
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15. An evaluation of percutaneous endoscopic gastrostomy feeding in AIDS

Author: P Flood, S Dowling, A Chua, Fiona Mulcahy, S Keating, P W N Keeling, and D. Kane
Subjects: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Peritonitis, Dermatology, Anorexia, Weight Gain, Enteral administration, Enteral Nutrition, Pharyngeal reflex, Percutaneous endoscopic gastrostomy, PEG ratio, medicine, Humans, Pharmacology (medical), Serum Albumin, Gastrostomy, Acquired Immunodeficiency Syndrome, business.industry, Age Factors, Public Health, Environmental and Occupational Health, medicine.disease, Nutrition Disorders, Surgery, Infectious Diseases, Parenteral nutrition, Female, medicine.symptom, business
Abstract: Between October 1991 and October 1993, 17 AIDS patients (14 intravenous drug users, 3 sexually acquired) were com menced on percutaneous endoscopic gastrostomy (PEG) feeding in St James's Hospital. Indications were progressive weight loss related to severe anorexia (11), persistent oesophageal candidiasis (5) and absence of gag reflex (1). Two patients requested PEG tube rem oval after one week because of cram py abdom inal pain without peritonitis. Five patients died from AIDS related infections within 6 weeks of PEG insertion. Ten patients were followed up for > 2 months (mean 5.2 months, range 2.5-15.5 months). In these 10 patients, 1 patient developed a PEG site infection which responded to topical antibiotics. There were no other complications. There was a significant ( P < 0.001) increase in energy and protein intake at 2 months. Variant degrees of weight gain occurred in all patients (mean 2.6 kg) (P < 0.01). Small but significant increases in other anthropometric variables occurred. Patients who died within 6 weeks of PEG insertion were older, and had a lower serum album in than the group who survived > 2 months (P < 0.01). A self-administered questionnaire demonstrated that the majority of patients found PEG feeding acceptable and preferable to nasogastric (NG) feeding.
Published: 1996
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16. Oral Presentations : Phisiology

Author: P. W. N. Keeling, C. Power, John V. Reynolds, P. Lawlor, Thomas M. Moran, Patrick J. Byrne, and N Ravi
Subjects: medicine.medical_specialty, medicine.diagnostic_test, business.industry, Pharynx, Gastroenterology, Reflux, General Medicine, medicine.disease, Dermatology, Endoscopy, Laryngopharyngeal reflux, Patient referral, medicine.anatomical_structure, Gastro, medicine, business
Published: 2004
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17. Irish Society of Gastroenterology

Author: M. Woods, L. J. D. O’Donnell, B. Battistini, T. Warner, J. Vane, M. G. Fartming, J. Yaqoob, J. J. Wu, L. A. Norris, M. I. Khan, P. W. N. Keeling, D. Maguire, G. O’Sullivan, B. Harvey, B. Curran, Y. Xin∘, E. W. Kay, M. Leader, K. Henry, O. Crosbie, S. Norris, P. Costello, C. O’Farrelly, J. Hegarty, B. Kennedy, M. Duggan, R. Plant, E. K. Kenny-Walsh, P. Cotter, M. J. Whelton, M. Maloney, N. Noonan, M. Buckley, H. Hamilton, S. Beattie, C. O’Morain, B. McNamara, J. Cuffe, R. A. Barry, D. A. Collins, G. C. O’Sullivan, J. K. Collins, F. Shanahan, M. M. Skelly, H. E. Mulcahy, A. Troy, T. Connell, C. Duggan, M. J. Duffyt, K. Sheahan, D. P. O’Donoghue, H. X. Xia, D. Hyde, M. G. O’Brien, E. F. Fitzgerald, G. Lee, A. J. Hussey, T. J. Boyle, B. Garrihy, O. P. Clinton, O. J. McAnena, G. O’Sulllvan, H. Corby, V. Donnelly, C. O’Herlihy, P. R. O’Connell, T. Deignan, J. Kelly, N. P. Breslin, C. MacDonnell, J. O’Keeffe, K. Mills, U. Srinivasan, R. Willoughby, C. Feighery, B. Twohig, K. Gaynor, P. F. O’Regan, S. Duggan, H. P. Redmond, J. McCarthy, D. Bouchier-Hayes, Q. Y. Ma, K. E. Williamson, B. J. Rowlands, A. Tobin, R. Pilkington, M. O’Donnell, E. O’Shea, A. Conroy, G. Kaminski, A. Walsh, I. J. Temperley, D. Kelleher, D. G. Weir, M. K. Barry, E. D. Mulligan, M. A. Stokes, M. G. O’Riordain, T. F. Gorey, K. F. McGeeney, J. M. Fitzpatrick, R. W. G. Watson, J. H. Wang, F. Campbell, D. Bennett, E. Kavanagh, P. O. Gorman, P. O’Regan, M. M. I. Yassin, M. McCaigue, T. G. Parks, A. A. B. Barros D’Sa, M. Lawlor, S. McElwaine, M. A. Heneghan, M. Kerins, J. Goulding, E. L. Egan, F. M. Stevens, C. F. McCarthy, M. Quirke, A. M. Eustace-Ryan, S. Qureshi, E. Aziz, A. Maree, S. Collins, T. Browne, S. Ahmed, B. O. Sullibhan, P. Smith, F. Walker, F. O’Connor, E. Sweeney, R. J. Farrell, M. Morrint, M. Goggins, and J. G. McNulty
Subjects: medicine.medical_specialty, Irish, business.industry, Ophthalmology, language, medicine, Library science, General Medicine, business, language.human_language
Published: 1995
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18. Irish Society of Gastroenterology

Author: P. K. Neelamakam, E. Brazil, S. Attwood, O. Traynor, J. Yaqoob, M. I. Khan, D. O’Toole, N. Noonan, C. Carey, D. Kelleher, D. G. Weir, P. W. N. Keeling, D. Monahan, L. Cogan, R. Willoughby, J. Jackson, A. Whelan, C. Feighery, G. Z. Kaminski, A. Conroy, S. Dooley, N. A. Parfrey, P. McEneaney, C. O’Morain, J. P. McGrath, R. C. Stuart, J. Hill, P. J. Byrne, C. Timon, S. C. S. Chung, A. VanHasselt, T. P. J. Hennessy, D. Hamilton, D. Mulcahy, D. Walsh, C. Farrely, W. Tormey, J. Fielding, G. Watson, A. Cherukuri, M. Maloney, D. O. Toole, M. Corcoran, J. Coffey, F. Butt, D. McAvinchey, P. V. Delaney, G. J. Burke, S. Youngprapakorn, U. Srinivasan, N. Leonard, C. O’Farrelly, C. O. Morain, C. A. Whelan, E. Barry, C. Collins, P. Costello, C. O’Herlihy, D. P. O’Donoghue, C. Clabby, J. McCarthy, E. Kenny-Walsh, M. J. Whelton, M. Morrin, F. Khan, P. Delaney, J. O’Keeffe, K. Mills, M. A. Bennett, E. W. Kay, H. Mulcahy, M. Leader, D. T. Croke, X. G. Fan, I. Khan, S. Keating, C. Morrison, M. Buckley, F. M. O’Reilly, C. Darby, M. G. Courtney, G. M. Murphy, J. F. Fielding, C. J. O’Boyle, T. J. Boyle, K. Mulhall, M. J. Kerin, D. Courtney, D. S. Quill, H. F. Given, S. Kehoe, R. Quirke, R. B. Stephens, S. Norris, G. McEntee, J. Hegarty, C. Farrelly, D. Thottaparambil, R. Thomas, G. Houghton, S. Sachithanandan, A. Geoghegan, S. Doyle, C. McCaul, T. N. Walsh, R. Farrell, B. Gusau, M. S. O’Mahoney, S. AlBloushi, J. Sachithanandan, J. Walshe, M. Carmody, J. Donohoe, A. G. Shattock, N. Parfrey, S. Lynch, L. Madrigal, J. McEntee, R. Murphy, Z. Ahmed, M. Ryan, C. Montwill, A. Morgan, P. Smith, F. Walker, A. Murphy, M. Moloney, S. McGrath, E. Taraneweh, A. K. Bhatia, D. O’Keeffe, P. McCarthy, E. Rajan, S. Albloushi, B. O’ Farrell, A. Shattock, D. Kearney, J. Lee, F. Gleeson, B. McNamara, J. Cuffe, G. C. O’Sullivan, B. J. Harvey, B. Curran, E. Kay, L. Lawler, S. E. A. Attwood, G. Bourke, J. Hyland, W. A. Owens, C. M. Loughrey, J. A. McAleer, K. G. McManus, J. F. Dillon, F. C. Wong, T. C. N. Lo, K. H. Chan, J. N. Plevris, N. D. C. Finlayson, J. D. Miller, I. A. D. Bouchier, P. C. Hayes, S. V. Walsh, L. J. Egan, C. E. Connolly, F. M. Stevens, E. L. Egan, C. F. McCarthy, Q. Y. Ma, G. D. Magee, J. E. Ardill, K. D. Buchanan, B. J. Rowlands, P. McGettigan, R. Chan, B. O’ Shea, J. McManus, J. Feely, J. Donoghue, N. Fanning, J. Mathias, P. Gillen, W. A. Tanner, F. B. V. Keane, D. M. Campbell, V. Donnelly, D. O’Connell, M. Behan, P. R. O’Connell, C. S. Ko, K. Mealy, B. M. Gusau, M. Goggins, J. Yakoub, R. J. Farrell, and N. Mahmud
Subjects: medicine.medical_specialty, Irish, business.industry, Ophthalmology, medicine, language, Library science, General Medicine, business, language.human_language
Published: 1995
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19. A change of IL-2 and IL-4 production in patients withHelicobactor pyloriinfection

Author: Xue-Gong Fan, X. J. Fan, P. W. N. Keeling, and Javed Yakoob
Subjects: Interleukin 2, business.industry, medicine.medical_treatment, Immunology, Inflammation, Cell Biology, Disease, bacterial infections and mycoses, Chronic infection, Cytokine, Immune pathogenesis, lcsh:Pathology, medicine, In patient, medicine.symptom, business, Interleukin 4, lcsh:RB1-214, Research Article, medicine.drug
Abstract: Helicobactor pyloriis the most common cause of gastroduodenal inflammation. However, the exact immune pathogenesis is not fully understood. To look for evidence of the immunological mechanism inH. pyloriassociated disease, we measured cytokine interleukin-2 (IL-2) and IL-4 levels produced by peripheral blood lymphocytes (PBL) and gastric biopsies in 20 subjects with or withoutH. pyloriinfection.H. pylorican stimulate IL-2 and IL-4 production from PBL inH. pylorinegative as well asH. pyloripositive individuals. The spontaneous IL-2 production by PBL and gastric biopsies was greater (p < 0.0025, H. pylorinegative individuals than that inH. pyloriinfected patients. Increased IL-4 levels from PBL inH. pyloriinfected patients were found in the presence ofH. pylori(p < 0.0025). An increased spontaneous production of IL-4 from gastric biopsies was also observed inH. pyloriinfected patients (p < 0.025). In conclusion, an enhanced type 2 cytokine production was observed inH. pyloriinfected patients, which may be responsible forH. pylorichronic infection.
Published: 1995
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20. Serotonin and physical illness: focus on non-ulcer dyspepsia

Author: P. W. N. Keeling, Timothy G. Dinan, and Andrew Seng Boon Chua
Subjects: Pharmacology, medicine.medical_specialty, business.industry, Disease, Serotonergic, medicine.disease, Gastroenterology, Neuroticism, Functional disorder, Prolactin, 030227 psychiatry, Buspirone, 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, Internal medicine, medicine, Pharmacology (medical), 030212 general & internal medicine, business, Irritable bowel syndrome, Psychopathology, medicine.drug
Abstract: The prevalence of psychopathology in patients presenting with functional bowel disorder to the gastroenterology department was determined using formal psychiatric rating scales. There was no evidence of excessive psychiatric disorder compared to a group of patients with peptic ulcer disease. However, greater trait scores for neuroticism and introversion were found in the functional disorder group, together with a greater reporting of life events perceived as negative. Central serotoninergic receptor role in the pathophysiology of functional dyspepsia was assessed using a neuroendocrine challenge test. Buspirone, an azaspirone, stimulates central serotoninergic-1A receptors and, as a consequence, releases prolactin, and the extent of prolactin release after the challenge is an indicator of central serotoninergic receptor sensitivity. The mean prolactin response was significantly greater in patients with functional dyspepsia than in healthy controls and peptic ulcer disease patients. The sensitivity of the central serotoninergic receptors was also highly correlated with the degree of delayed solid phase gastric emptying assessed scintigraphically. Finally, dyspeptic symptoms can be reproduced in patients by an intravenous cholecystokinin infusion and severity of response was analysed using a visual analogue scale.
Published: 2012

21. Irish Society of Gastroenterology

Author: D. F. Smith, N. Leonard, Michael J. Kerin, Brian J. Harvey, M. Duggan, Jiang Huai Wang, S. McDonald, J. S. A. Collins, Malachi J. McKenna, Frank B. V. Keane, Cormac T. Taylor, E. Mulligan, C. Kelly, N. Fanning, M. G. Goggins, David Bouchier-Hayes, W. A. Tanner, T. Hogan, F. Barker, S. Keating, B. T. Johnston, W. R.F. Ferguson, G. Thornton, Oliver J. McAnena, Colm O'Morain, G. P. McEntee, U. Srinivasan, K. B. Bamford, Alan W. Baird, Éanna J Ryan, O. Crosbie, A. Whelan, J. Crowe, Simon Keely, Terry Boyle, A. Pryde, J. Carton, Derek Moriarty, F. O’Brien, Niall Breslin, M. O’Riordain, S. Montague C. O'Morain, B. Crowley, N. McCallion, K. Synnott, D. P. O'Donoghoe, N. A. Parfrey, P. McEneaney, P. MacMathuna, Claire Condron, M. K. Barry, D. P. O’Donoghue, S. Doyle, T. P. J. Hennessy, Henry Paul Redmond, S. Beattie, J. M. Sloan, T. N. Walsh, J. K. Collins, M. Casey, R. B. Mooney, O. P. Clinton, M. A. Stokes, Cliona O'Farrelly, John M. Fitzpatrick, Dermot Kelleher, K. F. McGeeney, S. Duggan, I. Frazer, C. Feighery, H. Hamilton, A. G. Shattock, C. McCormick, Diarmuid O'Donoghue, P. McGurgan, G. O'Sullivan, K. C. Trimble, X. J. Fan, Thomas F. Gorey, P. R. O'Connell, D. Carroll, N. Mahmud, Margaret O'Mahony, G. Kelly, N. I. McDougall, T. C. K. Tham, L. Madrigal, Javed Yakoob, Peter J. Kelly, S. Douglas, R. C. Heading, J. Quinn, Gerald C. O'Sullivan, P. Lawlor, J. P. O'Donoghue, D. Maguire, Andrew H.G. Love, D. Booth, D. J. Reen, M. M. Skelly, D. Graham, E. M. Murray, Paul G. Horgan, F. Campbell, J. F. Fielding, X. G. Fan, K. Mealy, Donald G. Weir, R. Merriman, A. Long, R. C. Stuart, A. Keaveny, M. G. O'Sullivan, A. E. Brannigan, J. M. O≿donoghue, C. Morrison, A. Conroy, R. J. McFarland, S. Sachithanandan, Rosemarie Freaney, J. Lennon, Patrick J. Byrne, S. Al-Bloushi, P. Gillen, J. P. McGrath, G. S. A. McDonald, A. Weerkamp, R. G. P. Watson, C. Scanlon, P. W. N. Keeling, J. Hegarty, Maria M. Buckley, J. Mathias, M. C. Regan, Fergus Shanahan, R. W. G. Watson, K. Barry, M. G. Courtney, and Suzanne Norris
Subjects: medicine.medical_specialty, Irish, business.industry, Ophthalmology, language, Medicine, Library science, General Medicine, business, language.human_language
Published: 1994
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22. Irish Society of Gastroenterology

Author: P. O’Gorman, Cormac T. Taylor, John M. Fitzpatrick, M. G. Goggins, M. Madden, J. F. Fielding, B. T. Johnston, P. W. N. Keeling, N. Kieran, B. Curran, M. Maloney, Michael J. Duffy, N. Couse, Thomas F. Gorey, J. G. McNulty, M. Buckley, A. G. Shattock, M. O’Reilly, Mary B. Codd, M. M. Skelly, X. J. Fan, Éanna J Ryan, W. Mullins, W. O. Kirwan, A. K. Cherukuri, J. P. McGrath, B. Golden, G. Lee, John Hyland, M. A. Stokes, Peter A. Dervan, Patrick J. Byrne, S. Al-Bloushi, H. Holloway, Diarmuid O'Donoghue, K. M. Murphy, S. McGrath, D. H. Osborne, N. I. McDougall, E. W. Kay, J. Lennon, D. O’Donovan, G. O'Sullivan, T. N. Walsh, Colm O'Morain, P. K. Ellis, C. Doyle, A. O’Farrell, A. P. Moran, J. K. Collins, T. Carroll, G. O. Sullivan, Ciaran O’Reilly, F. M. O’Reilly, F. Mulcahy, A. S. Browne, J. Kelly, I. Khan, C. Kanduru, Peter J. Kelly, A. Murphy, Michael G. Harrington, T. Deignan, T. C. K. Tham, A. Quinn, C. O. Farrelly, P. V. Delaney, N. M. Codd, M. Leader, J. Morgan, Gerald C. O'Sullivan, E. Casey, M. P. Ryan, M. A. Bennett, C. G. M. Gahan, A. Long, P. MacMathuna, T. V. McCarthy, Y. Sharifi, M. C. Regan, Fergus Shanahan, B. J. O’Farrell, F. O’Brien, G. S. A. McDonald, T. Mulcahy, T. P. J. Hennessy, E. Jones, Dermot Kelleher, M. G. Courtney, C. B. O. Suilleabhain, K. J. Farrell, E. Rajan, Evelyn P. Murphy, R. G. P. Watson, G. Burke, A. Kitching, E. Fitzgerald, Andrew H.G. Love, E. J. Walsh, Michael Kennedy, Alan W. Baird, Mohamed Abuzakouk, Prakash Madhavan, Sally Ann Lynch, Martin J. O’Sullivan, Simon Keely, W. J. Primrose, D. Maguire, X. G. Fan, M. Goggins, M. C. Prabhakar, Hugh Mulcahy, R. J. McFarland, Seamus Morris, G. Thornton, Colm Bergin, Donald G. Weir, G. J. McKee, Cliona O'Farrelly, D. Royston, P. Neary, D. A. Egan, J. O’Shea, C. Carey, R. Merriman, Frank Kee, L. English, D. P. O’Donoghue, R. W. G. Watson, S. O’Briain, E. Mulligan, S. Reid, P. Quinn, Richard J. Farrell, P. Horgan, T. Gorey, M. I. Khan, Brian J. Harvey, Jiang Huai Wang, Nicholas P. Kennedy, J. S. A. Collins, David Bouchier-Hayes, N. Noonan, J. Crowe, P. R. O'Connell, Henry Paul Redmond, E. M. Mcllrath, F. Khan, D. T. Crake, and C. Feighery
Subjects: medicine.medical_specialty, business.industry, Section (typography), Library science, General Medicine, Cork, engineering.material, language.human_language, Irish, Ophthalmology, language, medicine, engineering, business
Published: 1994
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23. Gastric T lymphocyte responses to Helicobacter pylori in patients with H pylori colonisation

Author: Dermot Kelleher, X. J. Fan, P. W. N. Keeling, Chandreshwar N Shahi, J. Mcdevitt, and A. Chua
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, T-Lymphocytes, Spirillaceae, Antigen-Presenting Cells, Rapid urease test, Lymphocyte proliferation, Lymphocyte Activation, Gastroenterology, Helicobacter Infections, Immunophenotyping, Interferon-gamma, Antigen, Internal medicine, medicine, Humans, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Cells, Cultured, Aged, Antigens, Bacterial, Lamina propria, Helicobacter pylori, biology, Interferon-gamma production, business.industry, Stomach, Middle Aged, bacterial infections and mycoses, biology.organism_classification, medicine.anatomical_structure, Peripheral blood lymphocyte, Immunology, Cytokines, Interleukin-2, Female, Clinical Medicine, business, Research Article
Abstract: PUBLISHED, Helicobacter pylori has been identified as a dominant factor in the pathogenesis of duodenal ulcer. The aim of this study was to examine peripheral blood and gastric lymphocyte proliferation and cytokine production in patients with H pylori colonisation. Sixty five dyspeptic patients attending for endoscopy were studied; 35 of these were H pylori positive and 30 H pylori negative as assessed by culture, histology, and rapid urease test. H pylori antigen was capable of stimulating peripheral blood lymphocyte proliferative responses even in H pylori negative patients. Peripheral blood lymphocyte proliferative responses to H pylori (but not to purified protein derivative or phythaemagglutinin) were significantly lower in H pylori positive than H pylori negative patients. Similarly, antigen specific proliferative responses and interferon gamma production by gastric lamina propria lymphocytes were also depressed in H pylori positive patients compared with H pylori negative patients. CD8 and CD22 positive lamina propria lymphocytes were increased in H pylori positive patients. These data show that antigen specific responses to H pylori are significantly lower in H pylori positive patients and could indicate activation of antigen specific suppression.
Published: 1994
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24. National Scientific Medical Meeting 1994 Abstracts

Author: M. J. Turner, J. Upton, T. P. J. Hennessy, P. Kelehan, A. D. Crockard, Paul A. McGettigan, M. Grouden, Y. A. Cusack, Catherine Curran, B. Cryan, C. Pidgeon, T. G. Cooke, E. Shorten, B. M. Kinsella, P. Sweeney, A. Southey, S. G. Richardson, M. Sheehan, E. R. Horwitz, J. Belch, E. Griffin, E. Healy, A. Oakhill, H. Johnson, P. Shah, A. Kinsella, P. A O’Connell, P. Humphries, P. Lenehan, S. Fanning, C. N. Pidgeon, D. Pamphilon, M. T. P. Caldwell, B. Tuohy, P. Dack, J. Murphy, P. Gaffney, Fiona M. Stevens, C. Bergin, A. Locasciulli, G. Nolan, M. Kearns, D. F. Smith, J. P. H. Fee, I. Reid, Muiris X. Fitzgerald, T. Cawley, G. Swanwick, U. Kondaveeti, F. Davidson, A. Early, D. Noone, S. Farrell, A. Hale, C. M. Costello, L. English, Colm O'Herlihy, B. Crowley, J. F. Lyons, P. Kent, D. Coakley, M. Geary, L. J. Egan, M. Hogan, G. A. FitzGerald, P. White, R. Merriman, Mary Leader, M. Fitzgerald, N. AlAnsari, H. P. Singh, N. Mahmud, Sarah Rogers, T. Conlon, J. O’Shea, C. Larkin, Norman Delanty, L. Maguire, J. Mahady, J. T. Ennis, E. Creamer, R. P. Kernan, I. Temperley, M. Hargrove, J. Joseph Walshe, J. M. T. Redmond, B. Gilmer, Michael Hutchinson, J. Woof, K. D. Carson, C. Darby, D. Lyons, Michael T. Dawson, G. Gibson, A. B. Atkinson, J. A. Lawson, N. Ryall, D. S. O’Briain, R. Pilkington, W. Blunnie, T. Donoghue, D. M. O’Hanlon, S. Coulter-Smith, James R. Docherty, G. Mortimer, Enda W. McDermott, C. Conlon, T. Cooke, B. Hennelly, P. Boylan, P. Lawlor, S. Young, B. Marsh, R. J. Cunney, S. Lynch, W. O’Connor, M. C. Prabhakar, G. Dempsey, C. Fitzpatrick, L. Boissel, P. O’Callaghan, Terry J. Smith, B. P. McMahon, F. M. Ryan, D. Allcut, Sinead O’Neill, Emer Shelley, M. Coca-Prados, J. Lawson, E. G. Smyth, J. Geraghty, C. A. Whelan, M. Goggins, R.J. Cunney, B. McGeeney, A. J. Cunningham, P. Eustace, K. Carson, B. Sheridan, D. Powell, C. Foley-Nolan, P. M. Byrne, L. Barnes, G. King, C. Cullen, Maria A. O'Connell, Shaun Gallagher, G. J. Fitzpatrick, J. Mulhall, M. G. Mott, E. Shanahan, S. Murphy, D. Buggy, Cliona O'Farrelly, M. Buckley, T. M. Murray, G. McQuoid, D. O’Riordain, P. M. Bell, P. McNamara, P. Byrne, M. P. Colgan, S. Hone, T. J. McKenna, R. McManus, D. O’Neill, M. R. N. Darling, Aaj Adgey, P. Campbell, T. Finch, M. Robson, H. C. Loughrey, P. Foster, C. O’Keane, G. I. Adebayo, J. McEnri, J. D. Allen, Martin Cormican, C. Timon, E. O’Mongain, V. S. Donnelly, E. Corcoran, J. J. Gilmartin, M.J. Duffy, Brian J. Harvey, Peter P.A. Smyth, J. O. L DeLancey, Desmond J. Fitzgerald, J. Wang, T. Larkin, C. Barry-Kinsella, T. O’Connell, E. O’Callaghan, A Jefferson, G. D. Johnston, N. Shepard, A. L. Kennedy, I. M. Rea, C. F. McCarthy, D. Kerr, Margaret McLaren, G. Z. Kaminski, Hugh Staunton, P. Grainger, M. Norton, F. Lavin, B. F. McAdam, M. Maguire, R. Rafferty, M. Caldwell, R. Hone, C. M. MacDonagh-White, Dermot Kelleher, R. Namushi, G. MacKenzie, Michael J. Kerin, James Bernard Walsh, Mark Lawler, A. K. Cherukuri, U. Fearon, M. Doran, S. Orwa, J. Liu, N. Al fnAnsari, A. P. Heaney, K. Tipton, M. Glennon, H. Grimes, S. Hamilton, C. Smith, C. M. Kilgallen, Thomas Barry, R. Horgan, C. Saidtéar, V. Urbach, A. B. P. Cullinane, M. A. Christie, K. Daly, L. Madrigal, D. R. Hadden, C. McCreary, Q. Razza, Catherine Hayes, T. Walsh, T. Clarke, E. T. Burke, S. Liston, D. Mulherin, M. P. Reilly, D. Tansey, N. Cannon, V. P. Coffey, A. A. El-Magbri, D. P. O’Donoghue, P. W. N. Keeling, Jack Phillips, L. Condren, Jill J. F. Belch, J. R. Anderson, B. McAdam, Reza Mofidi, F. Hegarty, J. Kavanagh, Frances J. Hayes, D. Murray, E. Holmes, J. Fenton, J. Strattan, G. D. Wright, D. H. Hill, H. G. Nelson, A. C. Moloney, J. Goh, C. S. McArdle, G. Loughrey, J. Phillips, J. Fennell, T. Aherne, J. Stronge, S. Lewis, Kieran Sheahan, T. Markham, Madeline Murphy, P. J. Byrne, B. Harding, R. Hitchcock, M. Bourke, J. McSweeney, K. Colgan, Z. Johnson, D. Cotter, R. F. Harrison, Patricia Fitzpatrick, J. Feely, J. Crowe, H. F. Given, A. Mofidi, M. Hynes, E. B. McNamara, Michael J. Turner, T. Woods, Blánaid Hayes, J. Tyrrell, E. O’Toole, G. G. Lavery, A. M. Deveney, A. J. McShane, O. Bradley, B. Blackwood, O. White, L. W. Poulter, H. Maguire, E. S. Prosser, N. Dowd, Michael Kennedy, Peter J. Kelly, John J. O'Leary, K. Hickey, B. C. Morrow, P. Oslizlok, Malachi J. McKenna, J. Fabry, R. Chander, D. Clarke, C. O’Sullivan, M. O’Reilly, M. M. Young, F. Abuaisha, Clare O'Connor, N. A. Herity, J. Toland, D. Buckley, G. Kirk, E. Maguire, Cecily Kelleher, I. Hillary, H. D. Alexander, R. Keimowitz, L. H. Murray, S. Hennessy, D. Whyte, K. Holmes, M. S. Robson, J. Stratton, Conor T. Keane, B. Kanagaratnam, A. Heffernan, J. Golden, Anthony O'Grady, A. Tobin, J. I. O’Riordan, D. Sloan, Niall O'Higgins, A. Vance, A. Foot, B. Murphy, F. Mulvany, P. C. Sham, J. Higgins, P. M. Mercer, G. Browne, Y. Young, H. J. Gallagher, Thomas F. Gorey, A. Lane, Nollaig A. Parfrey, P. R. O’Connell, J. O’Neill, J. Adgey, Z. Imam, R. O’Sullivan, D. Maguire, L. Thornton, L. Drury, Douglas J. Veale, M. Reilly, M. Eljamel, A. W. Murphy, J. Laundon, M. Reidy, E. Ryan, A. Bacigalupo, C. O’Shaughnessy, B. Silke, R. A. Greene, J. P. McGrath, Connail McCrory, C. T. Keane, S. McMechan, J. Strangeways, T. O’Gorman, Malcolm D. Smith, M. Madden, G. Nicholson, B. O’Shea, A. McCann, M. Foley, G. Gearty, J. Hosseini, R. O’Moore, A. Taylor, A. M. Hetherton, Elizabeth Smyth, John V. Reynolds, J. A. B. Keogh, John Bonnar, D. Cafferty, D. Graham, J. R. Lennon, Barry Bresnihan, B. Denham, R. Holliman, M. B. O’Connor, Y. K. Tay, Padraic MacMathuna, M. S. Eljamel, H. Osborne, G. Shanik, S. M. Lavelle, R. Watson, Premkumar, M. Byrne, Fionnuala M. McAuliffe, S. Sharif, S. Killalea, E. Zimmermann, K. Kengasu, D. Duff, A. Hickey, D. McShane, J. Fogarty, M. Geoghegan, G. O’Reilly, T. Scott, P. Killeen, T. Kinsella, E. McIlrath, Helen M. Byrne, M. Borton, R. A. Rusk, J. M. McGinley, P. L. Yeoh, D. Warde, R. Stanwell-Smith, John Newell, M. Greer, David J. Brayden, E. M. Lavelle, C. D’Arrigo, J. McManus, R. Gonsalves, Barbara Murray, P. Murphy, G. D’Arcy, Camillus K. Power, N. Hughes, P. M. E. McCormack, R. Dwyer, N. Iman, R. B. Fitzsimons, S. C. Sharma, M. Carmody, Stewart R. Walsh, Gillian M. Murphy, E. McGuinness, L. Kevin, E. Barrett, S. K. Cunningham, A. Orren, S. Ni Scanaill, Karl Gaffney, P. McCormack, M. Martin, J. Malone, E. L. Egan, M. J. Walshe, D. Walsh, S. Kaf Al-Ghazal, M. Kuliszewski, S. Blankson, J. R. Sutherst, M. Lynch, M. T. Thornton, I. Boylan, Fiona Mulcahy, Oliver FitzGerald, T. N. Walsh, Y. Wen, K. McQuaid, D. R. McCance, M. Hall, U. Ni Riain, J. Hollyer, Michael Walsh, J. Donohoe, J. Doherty, D. Carney, D. J. Moore, S. E. Lawlor, K. Birthistle, H. S. Khoo Tan, A. M. Powell, G. Boyle, C. Burke, D. Veale, E. Lawlor, L. Zimmerman, M. Stewart, L. Hemeryck, Conor Burke, Irene B. Hillary, A. Pooransingh, K. Butler, P. W. Johnston, Daniel Rawluk, N. Foreman, M. J. Conran, B. L. Sheppard, P. Gilligan, D. Keane, E. Mulligan, D. Phelan, J. G. Kelly, J. Stack, Y. McBrinn, E. Sweeney, S. Calvert, E. A. Maguire, E. Keane, D. McKeogh, M. Post, S. N. Tham, P. Connolly, A. C. Gordon, Frank Gannon, Rosemarie Freaney, C. Collins, J. F. Malone, B. Moule, C. Saidlear, Seamus Sreenan, S. Teahan, J. McCann, J. Dixon, C. Quigley, J. L. Waddington, D. Maher, I. Graham, Diarmaid Hughes, S. Thomas, A. O’Leary, K. Carroll, A. M. Bourke, J. Candal Couto, N. Nolan, R. Harper, D. P. O’Brien, T. C. M. Morris, E. O’Leary, Michael M. Maher, M. White, C. Hallahan, N. Ni Scannlain, Colm O'Morain, E. Hayes, Luke Clancy, B. Stuart, P. Crean, J. Dowling, I. Cree, M. A. Heneghan, B. Cassidy, C. A. Barnes, Donald G. Weir, J. Flynn, E. Clarke, J. Stinson, N. Gardiner, R. Mulcahy, B. J. Harvey, Gerald C. O'Sullivan, G. S. A. McDonald, P. Costigan, P. O’Connor, D. Carrington, J. Goulding, C. Sheehan, A. Kitching, Conleth Feighery, M. LaFoy, E. Coleman, S. Pathmakanthan, C. Condon, S. B. Grimes, J. M. O’Donoghue, J. Hildebrand, Gerard Bury, A. W. Clare, S. Feely, S. R. McCann, J. A. O’Hare, B. E. Kelly, A. Moloney, M. Donnelly, D. O’Meara, and A. Chan
Subjects: medicine.medical_specialty, business.industry, Family medicine, Human immunodeficiency virus (HIV), Medicine, General Medicine, business, medicine.disease_cause
Published: 1994
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25. Irish society of gastroenterology

Author: M. Stack, R. G. K. Watson, David Bouchier-Hayes, P. R. O'Connell, Thomas N. Walsh, N. Noonan, D. Morrissey, J. Barrett, A. Husain, X. J. Fan, D. P. O’Donoghue, L. Madrigal, O. Crosbie, J. K. Collins, J. Morgan, M. T. P. Caldwell, Alan W. Baird, R. A. J. Spence, Simon Keely, Padraic MacMathuna, M. Moloney, Claire Condron, A. Finch, E. F. A. Spencer, S. G. Marshall, Brian J. Harvey, Jiang Huai Wang, H. Xia, X. G. Fan, K. Mealy, D. Maguire, K. M. Murphy, Hugh Mulcahy, M. O’Riordain, Fergal J. O'Brien, R. G. P. Watson, I. Frazier, N. Mahmud, John R. Kelly, M. Madden, D. McMaster, Patrick J. Byrne, David Gibbons, J. Crowe, G. O. Sullivan, Fergus Shanahan, C. A. Whelan, W. O. Kirwan, R. W. Parks, T. P. J. Hennessey, Alexander C.O. Evans, G. McEntee, E. Clarke, C. B. O’Suilleabhain, C. Kanduru, P. W. N. Keeling, J. Farrell, Henry Paul Redmond, R. W. G. Watson, Diarmuid O'Donoghue, M. J. Crowley, D. Lynch, O. Traynor, Sally Ann Lynch, E. M. Mcllrath, C. Feighery, T. P. J. Hennessy, P. Marks, Peter J. Kelly, John Hyland, H. J. Windle, Richard J. Farrell, D. Graham, Peter McCarthy, Colm O'Herlihy, D. G. Weir, P. L. Yeoh, Cliona O'Farrelly, N. A. Parfrey, J. Lennon, M. I. Khan, Michael J. Duffy, Gerald C. O'Sullivan, V. S. Donnelly, M. Crowley, M. O’Brien, M. M. Skelly, Mary Barry, A. K. Cherukuri, J. Carton, J. Hegarty, S. Reid, P. Quinn, G. Lee, G. W. Johnson, Paul G. Horgan, R. Merriman, T. G. Parks, Paul Neary, E. Fitzgerald, G. S. A. McDonald, P. White, C. Devereux, P. O’Leary, Y. T. Chuan, M. Borton, Suzanne Norris, W. A. Stack, Kieran Sheahan, R. McManus, S. A. McMillan, Dermot Kelleher, and D. J. Waldron
Subjects: Irish, business.industry, language, engineering, Optometry, Library science, Medicine, General Medicine, Cork, engineering.material, business, language.human_language
Published: 1994
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26. Seventeenth Sir Peter Freyer memorial lecture and surgical symposium

Author: E. O’Broin, J. Donohoe, K. Mealy, M. Kerin, P. Gillen, W. A. Tanner, F. B. V. Keane, P. McCarthy, S. Rubesin, H. Herlinger, I. Laufer, M. T. P. Caldwell, P. Lawlor, P. J. Byrne, T. N. Walsh, T. P. J. Hennessy, A. J. Curran, P. Gormley, K. Barry, M. McGuire, P. Marks, A. Syed Asad, B. Lane, H. I. Browne, P. Keeling, M. K. Barry, C. J. Yeo, P. K. Sauter, K. D. Lillemoe, H. A. Pitt, J. L. Cameron, S. Sostre, D. A. O’Donovan, C. J. Kelly, D. M. Bouchier-Hayes, H. P. Redmond, P. Burke, W. S. Monkhouse, J. Burke, N. Williams, T. Gorey, N. H. Afdhal, A. I. Butt, M. H. Vazir, R. Sullivan, C. E. Connolly, H. C. Bredin, J. P. Sweeney, D. Greene, R. Harkin, J. Thornton, M. R. Butler, T. E. D. McDermott, R. Grainger, J. Thornhill, M. J. Kerin, J. Wilkie, J. R. T. Monson, S. Duggan, J. McCarthy, R. G. W. Watson, D. T. Croke, M. McDermott, D. Croke, P. B. V. Keane, R. W. G. Watson, R. O’Donnell, A. F. Horgan, D. S. O’Riordain, I. Saporoschetz, J. A. Mannick, M. L. Rodrick, D. M. Baker, J. A. Jones, J. S. Nguyen-Van-Tam, D. L. Morris, J. D. Hardcastle, R. J. C. Steele, J. B. Bourke, J. H. Lloyd, S. Brown, S. E. A. Attwood, J. McGrath, M. Regan, S. McCann, R. B. Stephens, A. T. Devitt, T. J. O’Sullivan, B. J. Hurson, M. C. Regan, M. Hurson, S. J. Kirk, H. L. Wasserkrug, A. Barbul, E. R. Naidu, Tracy Sullivan, M. Colreavy, S. Kaf Al-Ghazal, J. McCann, M. Rodrick, K. J. Cronin, P. Butler, M. McHugh, G. Edwards, J. G. Geoghegan, D. J. Hehir, W. O. Kirwan, M. P. Brady, J. A. O’Donnell, D. Evoy, S. T. O’Sullivan, C. M. Reardon, M. A. Stokes, F. Bergin, P. Mercer, D. Murphy, N. O’Higgins, P. M. Cannon, J. F. R. Robertson, I. O. Ellis, R. W. Blarney, D. L. Manning, R. I. Nicolson, E. Mulligan, P. Kent, J. Ennis, M. Dowling, P. Dervan, J. M. Fitzpatrick, T. F. Gorey, D. M. Sibbering, M. H. Galea, D. A. L. Morgan, A. P. Locker, C. W. Elston, R. W. Blamey, S. P. M. Cannon, S. O’Rourke, M. Galea, A. Evans, I. Ellis, S. Johnston, J. Byrne, P. Horgan, M. Kennedy, J. Callaghan, H. F. Given, E. Mooney, S. Donohue, D. M. O’Hanlon, R. Waldron, J. Johnston, M. Stokes, E. MeDermott, M. Sharp, M. Duffy, J. Murphy, G. T. McGreal, W. Kealy, M. Neligan, K. O’Malley, G. McEntee, F. Khan, M. Morrin, P. Delaney, N. Brindley, S. Dudeney, J. Drebin, J. Geraghty, P. Broe, M. Fynes, P. G. Horgan, P. R. O’Connell, B. Golden, F. Loughnane, S. Baldota, M. O’Donnell, S. Chen, P. W. Eustace, J. G. Johnston, T. Gaffney, S. El Tawil, F. Cunningham, E. Brazil, J. Reynolds, A. Ireland, O. Traynor, D. Little, M. Barry, F. Thornton, S. Sheehan, D. J. Bouchier-Hayes, P. Fitzgerald, P. Grace, Y. Gul, D. Waldron, M. Wali, M. P. Colgan, D. J. Moore, D. G. Shanik, J. MacNamara, V. P. Lynch, H. Abdih, W. Watson, J. D. Aloisi, T. J. Boyle, H. Kim Lyerly, C. Kelly, D. O’Donovan, W. Monkhouse, J. M. O’Donoghue, C. Curran, D. O’Hanlon, D. Maher, C. Homer, M. O’Brien, M. Caldwell, R. Sheehan, P. Crean, T. O’Brien, C. Grant, J. A. Van Heerden, J. A. Lynn, B. G. O’Donovan, D. S. Quill, C. P. Delaney, J. Phillips, J. A. McKeever, M. J. Earley, A. C. B. Hooper, S. K. Al-Ghazal, K. Khan, M. McKiernan, R. McQuillan, J. R. McCabe, D. O’Farrell, J. O’Byrne, B. O’Donovan, I. Rafi, M. Gilmore, F. Fitzgerald, R. Moran, D. O’Brien, C. Pidgeon, S. Young, D. Allcutt, D. Rawluk, D. P. O’Brien, J. P. Phillips, I. Beckingham, M. Hinwood, K. Rigg, M. Bishop, H. Rowley, T. P. O’Dwyer, I. J. Beckingham, J. S. O’Rourke, M. J. S. Dennis, P. R. F. Bell, M. L. Nicholson, N. Akhtar, M. O. Corcoran, T. H. Lynch, G. Connellan, D. Mulvin, B. Boyle, M. O’Donoghue, Y. El-Tayeb, J. O’Donoghue, L. Parke, D. A. Evoy, S. E. Attwood, P. W. N. Keeling, J. Doyle, J. R. Flynn, J. Hurley, A. E. Wood, C. Duncan, A. Quershi, A. Leahy, D. Hayes, H. Osborne, H. Mashali, and R. G. K. Watson
Subjects: business.industry, Medicine, General Medicine, business, Classics
Published: 1994
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27. Irish society for gastroenterology

Author: R. Stephens, S. Duggen, K. O’ Byrne, A. Fournier, T. Jonsson, K. Al Khalifa, A. A. El-Magbri, E. E. Mooney, P. V. Delaney, K. Sweeney, Herbert Kim Lyerly, E. O’Nullain, A. Todd, M. J. G. Farthing, C. Carey, J. Johnston, F. Condon, R. G. P. Watson, A. Chua, E. Clarke, Maria M. Buckley, T. D. Warner, M. Duggan, John M. Fitzpatrick, Mary F. Casey, S. Baldota, T. Carroll, Patricia Daly, M. G. Goggins, A. Tanner, T. Nyhan, Mohamed Abuzakouk, A. Syed Asad, C. A. Harden, Conleth Feighery, H. F. Given, John Hyland, M. Moloney, D. Boucher-Hayes, O. Austin, C. E. Connolly, R. B. Stephens, M.J. Kerin, M. Maloney, M. C. Regan, A. Adeyoju, L. J. Egan, J. M. DiMaio, P. Kent, P. Keeling, Thomas F. Gorey, F. Khan, Enda W. McDermott, Cliona O'Farrelly, J. Crowe, Hugh Mulcahy, J. Lennon, D. McKeogh, P. W. N. Keeling, E. Sweeney, F. M. Stevens, Colm O'Morain, J. Callaghan, Maria A. O'Connell, R. W. G. Watson, O. Traynor, N. Barrett, A. P. Cleary, E. Mulligan, M. McKiernan, R. O’Sullivan, I. Khan, N. Noonan, J. Shami, Stewart R. Walsh, P. Neary, S. Johnston, R. P. Murphy, S. Reid, B. Lane, E. Kenny-Walsh, J. Phillips, C. T. Keane, B. Battistini, N. Mahmud, Ivan Keogh, D. C. Weir, C. A. Bannon, R. Merriman, J. J. Murphy, R. I. Farrell, Keith R. Berend, Richard J. Farrell, H. I. Browne, K. Mealy, Diarmuid O'Donoghue, F. B. V. Keane, E. Casey, P. Horgan, T. O’Gorman, X. G. Fan, C. K. Kilgallen, P. Madhaven, Conor T. Keane, Dermot Kelleher, P. Mac Mathúna, Donald G. Weir, M. I. Khan, C. Madden, Fiona M. Stevens, Henry Paul Redmond, H. X. Xia, A. K. Cherukuri, J. G. Johnston, C. O’Keane, R. Hone, C. F. McCarthy, R. Waldron, G. Lynch, M. Morrin, Jiang Huai Wang, D. Reen, L. J. D. O’Donnell, D. J. Waldon, D. R. Headon, R.E. Coles, D. Kane, P. J. Meagher, M. M. Skelly, Joseph Deasy, R. J. Vane, A. K. Cherukuril, Terry Boyle, M. J. Welton, R. J. Farrell, D. O’Hanlon, M. A. Stokes, T. C. K. Tham, M. Durkan, P. MacMathuna, X. J. Fan, J. Bruzzi, T. J. Egan, and H. Smyth
Subjects: medicine.medical_specialty, Pediatrics, Irish, business.industry, Family medicine, language, Medicine, General Medicine, business, language.human_language
Published: 1994
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28. Interferon-gamma and Tumour Necrosis Factor Production in Patients withHelicobacter pylori Infection

Author: Dermot Kelleher, P. W. N. Keeling, Maria A. O'Connell, A. Chua, and X. J. Fan
Subjects: Adult, Male, Necrosis, Peripheral blood mononuclear cell, Monocytes, Helicobacter Infections, Interferon-gamma, Immune system, Culture Techniques, medicine, Gastric mucosa, Humans, Interferon gamma, Cells, Cultured, Aged, Helicobacter pylori, biology, Tumor Necrosis Factor-alpha, business.industry, General Medicine, Middle Aged, biology.organism_classification, medicine.anatomical_structure, Gastric Mucosa, Gastritis, Immunology, Female, Tumor necrosis factor alpha, medicine.symptom, business, medicine.drug
Abstract: The production of the cytokines, interferon-gamma and tumour necrosis factor by human antral mucosa cells and stimulated peripheral blood mononuclear cells were determined by enzyme linked immunosorbent assay and L929 bioassay respectively. Tumour necrosis factor production by peripheral blood mononuclear cells in response to Helicobacter pylori stimulation was depressed in Helicobacter pylori positive individuals, compared to Helicobacter pylori negative individuals (P0.05). There was no difference in tumour necrosis factor production by peripheral blood mononuclear cells in response to purified protein derivative. However, tumour necrosis factor production by cells isolated from gastric mucosa during short term culture was significantly higher in Helicobacter pylori positive patients (P0.05) than negative patients, indicating a probable macrophage response. Levels of interferon-gamma did not differ significantly in the gastric explant culture from the two groups. The results show that Helicobacter pylori negative patients have a stronger peripheral cellular immune response to Helicobacter pylori infection. The higher levels of tumour necrosis factor production by antral mucosa cells in Helicobacter pylori positive patients may reflect the infiltration of T lymphocytes and macrophages within the local mucosa.
Published: 1993
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29. Irish society of gastroenterology

Author: J. Gilvarry, John M. Fitzpatrick, N. Williams, J. Stinson, R. B. Stephens, Y. Ellias, A. Chua, H. Hamilton, G. O’Dowd, E. O’Broin, B. G. Gazzard, J. Crowe, K. Ashbury, P. Kent, J. Feely, M. Abuzakouk, N. Barrett, Frank Kee, P. W. Hamilton, S. Somasundaram, M. Kelly, T. P. J. Hennessy, P. Broe, T. P. Caldwell, E. Casey, M. Stagg, John V. Reynolds, P. Lawlor, D. G. Weir, D. O’Donovan, Thomas F. Gorey, N. O’Donovan, Kevin O'Malley, S. Beattie, F. Khan, J. Keating, M. Neligan, M. D. McCaigue, T. Hennebry, Michael J. Kerin, E. M. Murray, M. Morrin, Timothy G. Dinan, Cliona O'Farrelly, J. Donohoe, John P. Burke, G. O’Sullivan, David Bouchier-Hayes, I. Menzies, X. J. Fan, R. J. Moorehead, N. Noonan, G. R. Barclay, G. Burke, L. C. Rovati, P. McMathuna, B. Rowlands, A. Ireland, H. Fenlon, A. M. O’Mahony, P. Erwin, S. E. H. Russell, C. Bergin, D. Kidney, C. Fallon, M. I. Halliday, C. O. Morain, F. Keeling, A. Duggan, P. Gillen, F. Malone, Maria M. Buckley, Mary Toner, Denis Evoy, W. A. Tanner, F. Loughnane, N. Mahmud, B. J. Rowlands, D. Evoy, N. Hall, Conleth Feighery, J. Geraghty, C. Kelly, C. A. O’Morain, M. Regan, D. P. O’Donoghue, Brendan M. Walsh, M. O’ Brien, Colm O'Morain, T. N. Walsh, H. Mulcahy, J. Smithson, W. Watson, S. E. A. Attwood, Alan W. Baird, M. C. R. Whiteside, Simon Keely, P. W. N. Keeling, G. McEntee, D. B. Stafford Johnson, Paul E. Burke, S. Dudley, N. Couse, O. Traynor, Dermot Kelleher, D. Bouchier Hayes, M. McCaigue, D. Bouchier-Hayes, P. J. Erwin, S. Cameron, J. Drebin, N. H. Anderson, Martin J. O’Sullivan, W. A. Stack, Fergal J. O'Brien, R. J. Maxwell, R. H. Wilson, M. McCarthy, Patrick J. Byrne, E. Mooney, Frank B. V. Keane, B. Clements, I. Bjarnason, R. J. Cahill, G. Thornton, M. Jeffers, B. Golden, P. V. Delaney, N. Brindley, Maria A. O'Connell, N. Francis, M. G. Goggins, P. Marks, K. R. Gardiner, J. K. Collins, X. G. Fan, K. Mealy, Donald G. Weir, P. Redmond, M. T. P. Caldwell, and I. Halliday
Subjects: Irish, business.industry, language, Library science, Medicine, General Medicine, business, language.human_language
Published: 1993
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30. Irish association of rheumatology & rehabilitation

Author: J. J. Cushnaghan, M. Farahat, M. McCabe, J. O’Byrne, R. Ehman, D. J. Reen, A. E. Irvine, M. Martin, Y. Hough, E. B. Casey, D. Feighery, F. McConneir, H. Dyson, U. Srinivasan, J. Ryan, M. Abuzakouk, S. Lau, J. Stack, J. T. Lie, A. L. Bell, F. Kirk, N. Hall, A. Campbell, C. Feighery, P. W. N. Keeling, D. Legge, A. Garrahy, D. Foley-Nolan, C. O. Farrelly, F. O’Gara, K. M. Magill, B. Bresnihan, G. S. Panayi, J. D. O’Duffy, M. Kearney, T. Smith, J. Cushnaghan, E. Wallace, H. Monaghan, A. M. Forde, A. Arora, D. A. Isenberg, J. Williams, R. J. Coughlan, M. McDermott, S. Stanhope, J. Hunt, C. McCarthy, M. M. Stephens, E. M. O. Nuallain, M. Sitiny, D. Veal, D. Weir, T. A. McNeill, M. P. Lynch, R. Posten, F. M. Mulcahy, H. Winska-Wiloch, J. McCarthy, G. H. Kingsley, S. Sant, J. R. McKane, R. B. Sim, S. J. McBride, C. Williams, J. M. Thompson, D. Brophy, P. A. Dieppe, D. Rowbotham, A. Murphy, M. G. Molloy, P. Dieppe, O. Beausang, M. X. Fitzgerald, F. Camilleri, A. Chua, J. Bonnar, A. O’Mally, A. G. Engel, C. O’Farrelly, M. McLaren, D. N. Golding, J. Byrne, J. D. Edgar, P. Cashin, K. Lohmann Siegel, S. Griffin, D. Mulcahy, J. Hassan, J. J. F. Belch, M. Lynch, G. Cunnane, M. Heffernan, G. Yanni, L. H. Gerber, P. Plunkett, M. J. I. Phelan, P. G. O’Connell, A. J. Bancroft, A. Whelan, Oliver FitzGerald, R. Cahill, H. Hamilton, A. Long, R. Bucknall, E. Ghadiali, A. D. Crockard, Dermot Kelleher, S. Donnelly, S. Beattie, J. Gilvarry, M. Harrison, R. Gibney, D. Mulherin, E. Choy, S. Eustace, C. O’Morain, E. Casey, E. Breathnach, B. Coughlan, and J. Jackson
Subjects: medicine.medical_specialty, Rehabilitation, business.industry, medicine.medical_treatment, General Medicine, language.human_language, Rheumatology, Irish, Family medicine, Internal medicine, medicine, language, Optometry, business
Published: 1993
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31. Irish society of gastroenterology

Author: M. C. Prabhaker, D. Coll, J. S. A. Collins, M. T. P. Caldwell, Madeleine Ennis, W. P. Joyce, A. M. O’Mahony, J. A. O’Donnell, H. E. Mulcahy, R. A. Smallwood, W. Lamort, J. Fitzpatrick, J. Dias, R. Gibney, K. O’Sullivan, P. W. Angus, A. D K Hill, C. Kelly, J. J. Crosbie, T. Gorey, J. O’Connell, J. M. P. Hyland, N. McLaughlin, E. Kay, C. Boreham, P. Kent, M. Madden, C. Hardiman, D. McCrory, J. Dolan, Marguerite Clyne, J. Burke, T. Corrigan, Paul E. Burke, C. Barry Walsh, P. D. Carey, S. Sant, P. Broe, M. Duggan, Kevin O'Malley, J. Crowe, M. J. Ryan, Henry Paul Redmond, C. A. Bannon, W. O. Kirwan, R. H. Wilson, J. Gilvarry, Mohamed Abuzakouk, S. Jazrawi, M. M. Skelly, D. Gillmore, Patrick J. Byrne, R. Alvi, James O'Donnell, A. Chong, M. G. Goggins, C. F. Johnston, S. Kee, M. O’Brien, Davina Fillmore, H. Hamilton, C. F. McCarthy, Colm O'Morain, P. W. N. Keeling, J. Jackson, T. N. Walsh, C. N. Shahi, G. T. McGreal, H. Y. Browne, P. Keeling, J. F. Fielding, David Bouchier-Hayes, H. Li, B. T. Johnston, C. McElearney, G. Lynch, N. Duckham, O. Traynor, E. Casey, C. Maguire, M. McNicholas, C. Feighery, C. H V Hoyle, Martin J. O’Sullivan, K. Williaon, S. M. Norris, R. J. Moorehead, A. Qureshi, S. Beattie, R. J. McFarland, R. G P Watson, G. R. Campbell, Hugh Mulcahy, M. P. Brady, E. Beausang, B. Lane, N. Menzies-Gow, Frank E. Murray, D. Bouchier-Hayes, R. B. Sewell, L. J D O’Donnell, T. Diamond, Donald G. Weir, R. J. Cahill, N. Swan, D. J. Hehir, B. Curran, R. F. McLoughlin, B. Goss, Dermot Kelleher, S. Namnyak, Peter J. Kelly, Pierce A. Grace, J. C. McLoughlin, D. Phelan, T. P. J. Hennessy, C. Hanvajanawong, A. M. O’Connor, N. Willia, Awad El Magbri, K. J. Cronin, C. Prendergast, Fiona M. Stevens, Joy Ardill, M. Buckley, Cliona O'Farrelly, J. K. Collins, K. Mealy, C. M. Reardon, M. Cyne, B. J. Rowlands, L. Joyce, S. Lynch, S. D. O’Broin, J. S. Doyle, R. O’Connell, D. P. MacErlean, J. Carr, E. W. Kay, F. H. Mourad, E. Ogutu, Éanna J Ryan, G. O'Sullivan, K. B. Bamford, H. Osborne, M. I. Halliday, J. E. Hegarty, A. L. Leahy, B. Kelleher, Robert G. Gibney, F. A. O’Connor, Brendan Drumm, S. Mulvey, M. G. Courtney, W. D. B. Clements, M. J G Farthing, B. O’Loughlin, W. S. Monkhouse, J. R T Monson, A. M. Forde, Keith D. Buchanan, John Hyland, Joseph Deasy, G. Thornton, M. Ferguson, S. M. Pender, S. Sheehan, D. D. Weir, Marina A. Lynch, D. P. O’Donoghue, John M. Fitzpatrick, M. Leader, J. Lennon, E. Clarke, George W. Johnston, Diarmuid O'Donoghue, John M. Scott, R. W. Parks, W. Stack, Andrew H.G. Love, Gerald C. O'Sullivan, T. G. Denesh, Nezam H. Afdhal, D. Stafford-Johnson, Thomas F. Gorey, T. C K Tham, D. A. Lutton, H. M. Fenlon, X. J. Fan, D. F. Hughes, M. Goggin, W. A. Stack, A. Chua, E. Mooney, P. MacMathuna, S. T. O’Sullivan, A. Darzi, Conor Patrick Delaney, D. O’Donovan, and M. M J McNicholas
Subjects: medicine.medical_specialty, Irish, business.industry, Family medicine, language, medicine, Optometry, General Medicine, business, language.human_language
Published: 1993
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32. Epidemiology

Author: B. Fixa, O. Komárková, K. Krejsek, J. Bures, Z. Nozicka, W. Giorcelli, M. Rodi, G. Camisasca, R. G. Martinotti, M. A. Mendall, P. M. Goggin, Nicola Molineaux, Joanne Levy, T. Toosy, D. Strachan, T. C. Northfield, T. Vorobjova, V. Vassiljev, K. Kisand, T. Wadström, R. Uibo, R. B. Zotz, S. G. Xu, G. von Recklinghausen, P. Meusers, H. Goebell, K. H Rhee, H. S. Youn, S. K. Paik, W. K. Lee, M. J. Cho, C. K. Park, Yuyuan Li, Pinjin Hu, Guoguang Du, Zhijin Wong, Stuart L. Hazell, Hazel M. Mitchell, J. D. de Korwin, P. Remot, Ph Hartemann, A. Catelle, M. C. Conroy, J. Schmitt, M. Stolte, E. Wellens, B. Bethke, M. Ritter, H. Eidt, S. Veldhuyzen van Zanten, L. Best, G. Bezanson, T. Marrie, E. Poniewierka, G. Gosciniak, T. Matysiak-Budnik, M. Quatrini, F. Boni, A. R. Baldassarri, A. De Vecchi, C. Castelnovo, E. Viganò, L. Tenconi, P. A. Bianchi, A. Carlucci, G. Ferrini, I Bianco, G. Larcinese, A. Di Sciascio, G. F. Fly, T. Hauge, J. Persson, L. G. V. Coelho, M. M. Teixeira, M. C. F. Passos, C. B. Givisiez, C. M. F. R. Santos, C. J. S. Rodrigues, Y. Chausson, L. P. Castro, Hannu Hyvärinen, Kari Seppälä, Eero Kivilaakso, Timo Kosunen, Martin Gormse, A. Pilotto, F. Vianello, D. Tornaboni, P. Dotto, G. Battaglia, F. Binda, F. Di Mario, P. M. Donisi, M. Pasini, M. E. Benve-nuti, V. Stracca-Pansa, M. Pasquino, H. Jablonowski, H. Szelényi, K. J. Hengels, G. Strohmeyer, N. Banatvala, K. Mayo, F. Megraud, R. Jennings, J. J. Deeks, R. A. Feldman, G. Bulighin, A. Ederie, S. Pilati, G. Franzin, G. Zamboni, M. Maran, R. Musola, A. Tobin, R. C. Hackman, G. B. McDonald, N. Fatela, J. Melo Cristino, L. Monteiro, F. Ramalho, A. Saragoça, M. J. Salgado, M. Cameiro de Moura, S. Pretolani, G. Gasbarrini, F. Bonvicini, M. Baraldini, E. Tonelli, M. R. A. Gatto, G. C. Ghironzi, F. M égraud, S. Bouchard, W. Lubcvzumiska-Kowalska, Z. Knapik, J. Meenan, M. Goggins, C. Shahi, P. W. N. Keeling, C. Keane, D. G. Weir, D. Vaira, M. Miglioli, P. Mulè, J. Holten, M. Menegati, G. Biasco, M. Vergura, A. Nannetti, L. Barbara, A. Boschini, M. Begnini, M. Menegatti, C. Ghira, A. D’Errico, D. G. Evans, M. A. Asnicar, D. J. Evans, D. Y. Graham, C. H. Lee, M. Coschieri, T. Fosse, M. C. St. Paul, J. R. Michiels, J. P. Delmont, J. L. Péroux, C. Pradier, P. Rampai, P. Pazzi, A. Merighi, S. Gamberini, R. Scarliarini, R. Bicochi, M. Libanore, G. Bisi, and S. Gulllini
Subjects: General Medicine
Published: 1992
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33. Immunology

Author: C. N. Shahi, X. J. Fou, A. Chua, T. McDevitt, M. O’Connell, D. G. Weir, P. W. N. Keeling, D. Kelleher, J. E. Crabtree, I. J. D. Lindley, L. K. Trejdosiewicz, P. Peichl, J.I Wyatt, N. Figura, D. S. Tomkins, M. Bughol, J. I. Wyatt, G. M. Sobala, J. N. Primioc, N. Weigert, S. Stolley, V. Schusdziarra, M. Classen, W. Schepp, E. J. Kuipers, M. Gracia-Casanova, A. S. Pena, J. B. A. Crusius, J. Defize, G. van Kamp, S. G. M. Meuwissen, G. Pals, E. Ryan, P. Mac Mathuna, P. Kelly, J. Lennon, J. Crowe, D. A. F. Lynch, N. M. Mapstoe, F. Lewis, F. Hassan, A. T. R. Axon, M. F. Dixon, P. E. Quirke, R. Karttunen, T. Karttunen, T. Kerola, S. Niemlä, T. U. Kosunen, M. T. De Magistris, S. Nuti, A. Di Tommaso, P. F. Bayel, C. Penhatini, M. Bugnoli, R. Rappuoli, S. Abrignani, J. C. Atherton, N. Hudson, T. L. Hale, G. E. Kirk, R. C. Spiller, C. J. Hawkey, L. A. Noach, N. B. Bosma, J. Jansen, M. Ceska, G. N. J. Tytgat, S. J. H. van Deventer, M. Tulliez, J. Guerre, E. Orsini, S. Chaussade, M. Gaudric, P. J. A. Willemse, M. P. M. de Maat, F. J. M. Godfroy, E. A. R. Knot, M.van Blankenstein, J. H. P. Wilson, and X. J. Fan
Subjects: General Medicine
Published: 1992
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34. Irish society of gastroenterology

Author: A. Brannigan, N. N. Williams, M. Grahn, N. S. Williams, J. M. Fitzpatrick, P. R. O’Connell, C. V. Soong, P. Blair, M. I. Halliday, J. M. Hood, B. J. Rowlands, A. A. B. Barros D’sa, R. J. Cahill, S. Beattie, H. Hamilton, C. O’Morain, S. J. Kelly, K. E. O’Malley, W. A. Stack, D. O’Donoghue, A. W. Baird, K. J. Cronin, M. J. Kerin, J. Crowe, P. MacMathuna, J. Lennon, T. F. Gorey, A. Chua, V. O’Kane, T. G. Dinan, P. W. N. Keeling, E. Mulligan, K. L. Cronin, P. Dervan, A. Ireland, D. Murphy, G. O’Sullivan, E. Ryan, P. Kelly, J. Gilvarry, S. Sant, X. J. Fan, C. N. Shahi, M. O’Connell, D. G. Weir, D. Kelleher, J. McDevitt, J. M. O’Donoghue, P. G. Horgan, W. J. Byrne, M. McGuire, H. F. Given, M. A. Daw, P. Kavanagh, P. O’Mahony, T. Joy, F. Gleeson, A. Mullan, M. Gibney, Anne Mannion, F. M. Stevens, C. F. McCarthy, A. A. Killeen, P. M. Murchan, J. V. Reynolds, N. Leonard, P. Marks, F. B. V. Keane, W. A. Tanner, M. A. O’Connell, B. Corridan, R. Collins, R. Shannon, R. Cahill, W. P. Joyce, M. Goggin, J. Hyland, O. Traynor, A. Qureshi, M. DaCosta, N. Brindley, P. Burke, P. Grace, D. Bouchier-Hayes, A. L. Leahy, G. Courtney, H. Osbome, N. O’Donovan, M. O’Donoghue, J. K. Collins, D. Morrissey, J. E. McCarthy, H. P. Redmond, A. D. K. Hill, P. A. Grace, H. Naama, O. M. Austin, D. M. Bouchier-Hayes, J. M. Daly, D. Breslin, C. P. Delaney, S. T. O’Sullivan, G. C. O’Sullivan, W. O. Kirwan, C. D. Weir, L. T. McGrath, S. Maynard, N. H. Anderson, C. Gokulan, T. A. O’Gorman, E. Breshihan, Pin Yin Lam, R. Skehill, H. Grimes, J. A. McKeever, M. A. Stokes, D. Mehigan, T. V. Keaveny, J. Meehan, A. Molloy, C. Q’Farrelly, J. Scott, M. S. Dudeney, A. Leahy, P. A. Grace., G. McEntee, N. D. Hcaton, V. Douglas, R. Mondragon, J. O’Grady, R. Williams, K. C. Tan, H. X. Xia, C. T. Keane, C. A. O’Morain, A. O’Mahony, A. Corbett, P. Harte, H. Mulcahy, S. Patchett, W. Stack, M. Gallagher, K. Connolly, J. Doyle, J. R. Flynn, M. Maher, D. Hehir, A. Horgan, R. Stuart, M. P. Brady, P. W. Johnston, B. T. Johnston, B. J. Collins, J. S. A. Collins, A. H. G. Love, S. G. Marshall, T. G. Parks, R. A. J. Spence, H. J. O’Connor, K. Cunnane, M. Duggan, P. MacMalhuna, M. Kerin, S. E. A. Attwood, L. Viani, M. Jeffers, T. N. Walsh, P. J. Byrne, I. Frazer, T. P. J. Hennessy, G. L. Hill, W. Dickey, S. A. McMillan, C. Bharucha, K. G. Porter, H. Rolfe, J. Thornton, J. Coleman, R. B. Stephens, S. Hone, K. Holmes, I. P. Kelly, T. P. Corrigan, D. McCrory, M. McCaigue, G. R. Barclay, M. Quirke, J. E. Hegarty, D. P. O’Donoghue, D. O’Hanlon, and J. Byrne
Subjects: medicine.medical_specialty, Irish, business.industry, Ophthalmology, language, Medicine, Library science, General Medicine, business, language.human_language
Published: 1992
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35. Sixteenth sir peter freyer memorial lecture and surgical symposium September 13th & 14th, 1991 Session I

Author: J. Coulter, R. G. Molloy, K. T. Moran, R. Waldron, W. O. Kirwan, C. O’Suilleabhain, A. Horgan, K. Mealy, P. Burke, J. Hyland, A. F. Horgan, M. Sheehan, R. M. Browne, O. Austin, A. P. Clery, J. M. Deasy, S. Sulaiman-Shoaib, J. Soeda, D. S. O’Briain, P. Puri, E. C. Coveney, V. McAllister, E. W. M. McDermott, N. J. O’Higgins, M. Maher, M. T. P. Caldwell, P. Murchan, W. Beesley, T. M. Feeley, W. A. Tanner, F. B. V. Keane, F. Abbasakoor, S. E. A. Attwood, L P. McGrath, R. B. Stephens, E. O’Broin, M. G. Davies, J. McGinley, C. Mannion, S. Gupta, M. F. Shine, F. Lennon, G. Ninan, R. J. Fitzgerald, E. J. Guiney, B. O’Donnell, A. F. O’Donnell, D. Luke, A. E. Wood, P. G. Murphy, T. N. Walsh, A. D. K. Hill, H. Li, T. P. J. Hennessy, N. Noonan, B. Breslin, P. W. N. Keeling, A. J. Curran, D. B. Gough, I. R. Davidson, P. Keeling, D. P. O’Leary, A. Smythe, N. C. Bird, A. G. Johnson, P. Nicholson, O. Traynor, K. Dawson, J. Aitken, B. A. Cooke, S. P. Parbhoo, N. N.Williams, J. M. Daly, M. Herlyn, D. Bouchier-Hayes, R. C. Stuart, M. J. Allen, W. D. Thompson, A. L. G. Peel, D. T. Hehir, K. Cronin, A. McCann, P. A. Dervan, S. J. Heffernan, W. P. Hederman, M. H. Galea, B. Dilks, A. Gilmour, L. O. Ellis, C. W. Elston, R. W. Blarney, S. O’Rourke, A. Mookens, R. Carter, D. Parkin, N. F. Couse, C. P. Delaney, P. G. Horgan, J. M. Fitzpatrick, T. F. Gorey, J. M. O’Byrne, J. P. McCabe, M. Stephens, F. McManus, J. L.Mangan, D. A. Barr, G. J. Mulvenna, P. Maginn, W. G. Kernohan, R. A. B. Mollan, S. J. O’Flanagan, J. P. Stack, P. Dervan, B. Hurson, S. Tierney, P. Fitzgerald, T. O’Sullivan, P. Grace, J. P. Wyatt, R. J. Evans, S. P. Cusack, S. McGowan, E. McGovem, S. D. Schwaitzberg, R. J. Connolly, R. P. Sullivan, G. Mortimer, J. G. Geraghty, P. J. O’Dwyer, B. S. McGlone, D. P. O’Brien, H. A. Younis, H. F. Given, C. Phelan, J. Byrne, K. Barry, D. Gough, L. Hanrahan, F. Given, J. P. Sweeney, A. M. Korebrits, J. V Reynolds, T. F Gorey, D. M. O’Hanlon, M. A. Stokes, H. P. Redmond, J. McCarthy, P. Losty, M. Murphy, P. E. M. Butler, P. G. Grace, J. R. Novell, S. K. Hobbs, O. Smith, G. Hazlehurst, B. Brozovic, K. Rolles, A. Burroughs, S. Mallett, A. Mehta, D. Buckley, D. Waldron, D. O’Brien, C. Curran, L. Grey, A. Leahy, A. Darzi, D. Leader, P. Broe, J. G. Geoghegan, C. A. Cheng, D. C. Lawson, T. N. Pappas, D. O’Sullivan, M. M. Lieber, T. V Colby, D. M. Barrett, E. Rogers, J. Greally, H. C. Bredin, M. O. Corcoran, M. Kenny, P. Horgan, D. Headon, A. Grace, P. A. Grace, S. Cross, D. Hehir, S. O’Briain, P. Hartigan, M. P. Colgan, D. Moore, G. Shanik, S. Z. Zaidi, D. J. Hehir, K. S. Cross, D. J. Moore, D. G. Shanik, P. Lacy, J. E. Coleman, C. S. McEnroe, J. A. Gelfand, T. F. O’Donnell, A. D. Callow, D. J. Buckley, D. S. O’Riordain, J. A. O’Donnell, P. Meagher, K. Boos, P. Gillen, T. Corrigan, R. Vashisht, M. Sian, E. J Sharp, M. K. O’Malley, M. J. Kerin, D. Wilkinson, A. Parkin, R. C. Kester, M. M. Maher, R. P. Waldron, D. J. Waldron, M. P. Brady, M. Allen, T. H Lyncy, B. Waymont, L. Emtage, G. R. Blackledge, M. A. Hughes, D. M. A. Wallace, L. Mynderse, H. Grimes, F. Chambers, D. Lowe, B. Prasad, D. C. O’Sullivan, M. Barry P. Gillen, M. McNicholas, H. Bredin, T. H. O’Dowd, M. Corcoran, J. M. O’Donoghue, M. McGuire, A. McNamara, T. Creagh, R. Grainger, T. B. D. McDermott, M. R. Butler, M. Gleeson, T. E. D. McDermott, J. P. Hurley, R. Hone, M. Neligan, J. Hurley, M. White, P. McDonagh, D. Phelan, E. McGovern, F. Quinn, F. Breatnach, A. O’Meara, J. P. McGrath, S. R. McCann, E. F. Gaffney, A Hennessy, M. Leader, F. S. Taleb, M. V. McKiernan, P. J. Leyden, J. J. McCann, J. Coleman, A. Quereshi, N. Ajayi, G. McEntee, H. Osborne, D. J. Bouchier-Hayes, S. Johnston, K. O’Malley, E. Smyth, D. L Bouchier-Hayes, P. R. O’Connell, T. Gorey, O. J. McAnena, M. W. Reed, J. L. Duncan, C. S. Reilly, C. McGibney, P. Lawlor, B. Lawless, E. McGuinness, and S. Leahy
Subjects: business.industry, Medicine, General Medicine, Session (computer science), business, Classics
Published: 1992
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36. Royal academy of medicine in ireland section of biological sciences

Author: W. Bourke, C. O’Connor, M. X. Fitzgerald, T. J. McConnell, A. Kent, E. M. Redmond, A. K. Keenan, E. M. Smyth, R. Shanahan, N. O’Donnell, C. M. O’Connor, V. Kelly, C. Barry-Kinsella, S. C. Sharma, E. Cottrell, R. F. Harrison, B. L. Sheppard, J. Bonnar, O. McNally, B. Hannigan, J. M. Allen, J. Feely, D. Buggy, M. Barry, P. W. N. Keeling, D. G. Weir, A. Breathnach, B. Keogh, T. Cooke, J. Murphy, C. O’Sullivan, M. Walsh, J. Tyrrell, C. Bergin, M. Colgan, D. Moore, D. G. Shanik, A. Southey, E. Costello, B. Jehn, R. Marti, R. Deane, F. Thornton, R. Jaggi, F. Martin, C. Armstrong, D. Mannion, T. Feely, G. Fitzpatrick, P. M. E. McCormack, E. O’Reilly, J. B. Walsh, D. Coakley, J. C. Stinson, C. M. Murphy, J. F. Andrews, G. H. Tomkin, J. P. Howe, D. J. Fogarty, D. Manahan-Vaughan, M. J. Rowan, R. Anwyl, K. D. Thornbury, S. M. Ward, K. M. Sanders, M. Murnin, D. J. S. Guthrie, G. B. Irvine, E. Doyle, C. M. Regan, J. Bannigan, J. Giles, G. I. Adebayo, P. B. Deasy, A. A. M. Omara, M. B. Lambert, T. D. Shields, S. O’Kane, D. Leckey, W. S. Gilmore, B. M. Hannigan, D. McKeogh, A. Bradford, R. G. O’Regan, P. Nolan, F. McEvoy, T. Edgell, P. Webbon, L. Creighton-Kempsford, P. J. Gaffney, M. D. O’Donnell, K. F. McGeeney, E. Breslin, K. Smith, J. R. Docherty, N. Adams, J. Ravey, A. J. Bell, K. K. Tong, J. J. Strain, D. M. Walsh, G. D. Baxter, B. Mokhtar, R. Victory, D. Bergin, C. Cooney, M. Staunton, J. Fitzgerald, J. Gardiner, W. Blunnie, J. Smith, O. Magee, D. Lowe, R. Robinson, J. Magner, P. Eustace, C. J. Martyn, C. M. Cooney, H. Adams, J. B. Lyons, W. P. Blunnie, and D. C. Moriarty
Subjects: business.industry, Section (typography), Medicine, Library science, General Medicine, business, Biological sciences
Published: 1992
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37. Irish society of gastroenterology

Author: L. A. Cotter, M. Healy, M. Buckley, C. O’Morain, C. Keane, R. R. O’Moore, W. Dickey, G. Roberts, G. Orr, K. Porter, D. McCrory, M. I. Halliday, M. Hoper, A. Crockard, B. J. Rowlands, A. Chua, T. Dinan, B. Dunbar, D. G. Weir, P. W. N. Keeling, B. T. Johnston, J. S. A. Collins, R. J. McFarland, A. H. G. Love, A. Darzi, C. T. N. Speakman, A. Spigelman, M. M. Henry, W. A. fnTanner, G. P. fnMcEntee, F. B. fnKeane, O. Tighe, M. Bennett, H. Mulcahy, N. N. Williams, J. P. Duignan, D. Bouchier-Hayes, D. O’Donoghue, D. T. Croke, A. D. Hill, T. N. Walsh, T. P. J. Hennessy, M. Goggin, W. P. Joyce, C. Prendergast, E. Gibney, O. J. Traynor, J. Hyland, S. O’Brien, M. X. Fitzgerald, J. E. Hegarty, A. Leahy, P. Grace, A. Qureshi, M. Leader, P. Broe, S. Eustace, N. Blake, J. McDevitt, C. F. Feighery, C. O’Farrelly, D. Kelleher, M. A. O’Connell, M. A. Stokes, G. L. Hill, P. Gaffney, J. O’Leary, C. Doyle, J. Hogan, Anne Gaffney, S. E. A. Attwood, P. Murphy, R. B. Stephens, R. H. Wilson, R. Gilliland, F. Kee, J. M. Sloan, R. J. Moorehead, G. ’Suilleabhain, A. Horgan, W. O. Kirwan, G. T. Deans, M. Heatley, K. Williamson, T. G. Parks, B. J. Rowland, R. A. J. Spence, K. Mealy, P. Burke, M. Herlyn, H. P. Redmond, A. P. Clery, J. M. Deasy, O. Austin, J. Meenan, R. J. Canili, P. M. Mathias, S. Beattie, H. Hamilton, J. G. Geoghegan, C. A. Cheng, D. C. Lawson, T. N. Pappas, R. Collins, S. Beatie, J. K. Collins, G. O’Sullivan, A. Corbett, W. D. B. Clements, P. MacMathuna, M. Lombard, A. Gimson, D. Westaby, R. Williams, M. Duggan, J. Lennon, J. Crowe, A. J. Ritchie, F. Johnston, J. McGuigan, J. R. P. Gibbons, K. D. Buchanan, J. M. Gilvarry, R. Robinson, J. F. Fielding, M. Lawler, P. Humphries, O. Sheils, D. S. O’Briain, J. McCarthy, M. McDermott, D. Hourihane, H. Gallagher, M. Barry, F. Lennon, W. P. Hederman, P. R. O’Connell, T. F. Gorey, J. M. Fitzpatrick, J. M. Daly, J. E. Carthy, H. Redmond, D. Croake, P. A. Grace, G. Campbell, O. Maguire, S. Lynch, J. Atwood, L. Madrigal, J. Attwood, A. Murphy, P. Shovlin, J. Hegarty, V. Egleston, D. P. MacErlean, S. Johnston, K. O’Malley, G. McEntee, E. Smyth, B. Moran, G. Plant, M. Rees, N. Brindley, H. Osborne, B. Lane, G. Lynch, J. Geraghty, D. Murphy, M. O’Brien, and P. Harte
Subjects: Irish, business.industry, language, Library science, Medicine, General Medicine, business, language.human_language
Published: 1992
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38. Dissolution of cholesterol gall stones using methyltertbutyl ether: a safe effective treatment

Author: P. W. N. Keeling, Andrew Seng Boon Chua, D. G. Weir, J. Mcnulty, S. Ah-Kion, and J.J. Keating
Subjects: Adult, Methyl Ethers, medicine.medical_specialty, Percutaneous, medicine.drug_class, medicine.medical_treatment, Cholecystography, Injections, Intralesional, Catheterization, Cholelithiasis, Humans, Medicine, Aged, Aged, 80 and over, Chemotherapy, medicine.diagnostic_test, Bile acid, business.industry, Gallbladder, Gastroenterology, Middle Aged, medicine.disease, Surgery, Catheter, Cholesterol, medicine.anatomical_structure, Solvents, Cholecystectomy, Bladder stones, business, Ethers, Research Article
Abstract: Methyltertbutyl ether (MTBE) administered by percutaneous transhepatic catheter rapidly dissolves radiolucent cholesterol gall bladder stones. However, complete dissolution and clearance of non-cholesterol debris is essential to prevent recurrence. In this study we analysed 25 consecutive patients with reference to efficacy and recurrence based on the presence or absence of non-cholesterol stone fragments after dissolution. Placement of the catheter was successful in 24 patients, one patient requiring cholecystectomy for bile peritonitis. MTBE was infused and aspirated continuously, four to six cycles per minute, resulting in rapid stone dissolution (median six hours; range 4-23 hours for solitary stones and median seven hours, range 4-30 hours for multiple stones). In 18 patients who had complete dissolution, four (22%) had recurrent stones within six to 18 months. Five patients had residual debris which failed to clear completely despite bile acid treatment. One patient with an incomplete rim of calcium in a large stone did not respond to MTBE treatment. A further patient required cholecystectomy for symptomatic recurrence. There were no serious side effects observed. MTBE treatment is a rapid, safe, and effective treatment for patients who refuse surgery or who for medical reasons cannot undergo cholecystectomy. The results of this study confirm that complete dissolution of all fragments is essential and may prevent recurrence.
Published: 1991
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39. Irish Society of Gastroenterology

Author: W. J. Campbell, T. G. Parks, R. A. J. Spence, N. C. Nevin, S. Jazrawi, T. N. Walsh, P. J. Byrne, H. Li, T. P. J. Hennessy, A. D. K. Hill, C. Bolger, E. J. Prendiville, A. Corbett, G. O’Sullivan, J. K. Collins, M. O’Sullivan, S. Nolan, M. O’Donoghue, Brenda O’Donoghue, D. McCabe, S. O’Brien, J. Dowsett, M. X. Fitzgerald, J. E. Hegarty, L. Madrigal, S. Lynch, D. Kelleher, C. Feighery, D. G. Weir, C. O’Farrelly, J. Meenan, F. Mulcahy, P. W. N. Keeling, H. Mulcahy, S. Patchett, N. Afdhal, D. P. O’Donoghue, M. Toner, I. L. Daly, C. McCarthy, R. Collins, S. Beattie, C. Keane, C. O’Morain, N. McEniff, S. Hamilton, M. D. O’Donnell, N. P. Nolan, E. Foster-Smith, K. F. McGeeney, G. Burke, W. P. Joyce, P. V. Delaney, K. F. Choo, F. M. Stevens, M. Maher, R. Waldron, M. T. P. Caldwell, P. Murchan, W. Beesley, T. M. Feeley, W. A. Tanner, F. V. B. Keane, M. A. Stokes, G. L. Hill, H. J. O’Connor, P. L. Redmond, W. Dickey, R. G. P. Watson, K. G. Porter, H. X. Xia, M. A. Daw, C. T. Keane, C. A. O’Morain, K. R. Gardiner, N. H. Abderson, M. D. McCaigue, P. J. Erwin, M. I. Halliday, B. J. Rowlands, S. E. A. Attwood, K. Mealy, J. McGrath, F. Abbasakoor, R. B. Stephens, P. Nicholson, J. Hyland, O. Traynor, I. Grosjean, F. O’Brien, S. T. Irwin, M. Barry, O. J. Traynor, K. C. Tan, E. J. Guiney, J. O’Grady, R. Williams, J. P. McGrath, J. Byrne, D. Timon, C. Armstrong, and D. S. Quill
Subjects: Irish, business.industry, language, Library science, Medicine, General Medicine, business, language.human_language
Published: 1991
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40. Irish society of gastroenterology

Author: E. J. Fitzgerald, A. Chua, C. Clabby, P. W. N. Keeling, J. M. Gilvarry, F. Keeling, O. Fitzgerald, J. F. Fielding, Elizabeth Mathai, T. O’Riordan, A. Tobin, S. Beattie, M. Cafferkey, C. T. Keane, C. O’Morain, P. J. O’Dwyer, A. Hassan, J. J. Murphy, N. J. Higgins, D. Kelly, G. P. McEntee, K. F. McGeeney, J. M. Fitzpatrick, D. P. Halpin, P. M. O’Byme, G. McEntee, T. P. Hermessy, R. B. Stephens, J. P. Hurley, P. Keeling, S. O’Brien, M. Keoghan, N. Afdhal, J. E. Hegarty, P. Burke, M. Sharp, O. Traynor, R. G. Molloy, M. G. O’Riordan, P. Gillen, W. O. Kirwan, E. Mathai, T. Keane, P. T. Byrne, R. Stuart, P. Lawlor, G. O’Sullivan, T. P. J. Hennessy, J. Hourihane, R. Stephens, F. J. Mullan, G. R. Campbell, J. Rowlands, S. T. D. McKelvey, F. I. Mullan, H. K. Wilson, W. Majury, J. Mills, A. J. Cromie, M. J. Kerin, D. O’Farrell, R. P. Waldron, J. G. Johnson, K. C. Trimble, D. P. Nunes, M. G. Courtney, L. Pomeroy, A. G. Shattock, F. M. Mulcahy, D. G. Weir, S. Ah-Kion, N. Noonan, J. Murphy, J. McNulty, M. Casey, M. X. Fitzgerald, B. Waldon, P. T. Cullen, D. Hopwood, D. Sutton, N. Kennedy, F. C. Campbell, N. MacMahon, B. Hogan, J. Murray, J. S. Doyle, J. M. Deasy, J. Carr, C. Bouchier-Hayes, A. P. Cleary, T. N. Walsh, W. F. Gawley, P. M. O’Byrne, M. I. Gleeson, D. T. Calthorpe, B. E. Lane, S. J. Heffernan, H. Sanfey, J. Steer, D. Cottell, M. Steer, T. F. Gorey, N. Nolan, P. Byme, R. Stewart, E. Nolan, E. Jones, M. MacMahon, P. Brennan, E. Carmody, D. Nizar, H. Osbome, R. L. O’Dwyer, F. Stevens, F. McCarthy, A. P. Clery, D. Bouchier-Hayes, S. Crerand, T. M. Feeley, R. Waldron, T. Corrigan, W. Hederman, and F. O’Cormell
Subjects: endocrine system, medicine.medical_specialty, endocrine system diseases, business.industry, Thyroid, General Medicine, Dapsone, medicine.disease, Asymptomatic, Gastroenterology, Anti-thyroid autoantibodies, Coeliac disease, medicine.anatomical_structure, Internal medicine, Dermatitis herpetiformis, medicine, Gluten free, Thyroid function, medicine.symptom, business, medicine.drug
Abstract: Abnormalities of the thyroid gland are said to be common in patients with dermatitis herpetiformis (DH), treated with dapsone (Thyroid abnormalities in dermatitis herpetiformis. Cunningham andZone, Annals Int.Med. 1985: 102, 194-196). Thepossibility that the goitrogenic effects of dapsone may play a role in this has not been evaluated. We therefore studied thyroid abnormalities in 40 patients with DH, 25 of whom were taking dapsone and 15 of whom were on a gluten free diet alone. All patients were examined clinically for evidence of thyroid dysfunction and blood was drawn for total thyroxine, thyrotrophin levels and thyroid microsomal antibdy titres. Six (24%) of dapsone treated patients had thyroid abnormalities, compared to 1 (7%) of the 15 patients treated with diet alone. Two patients became thyrotoxic when on treatment with dapsone. One patient had myxoedema prior to diagnosis of DH and one developed myxoedema while on dapsone. Two patients with asymptomatic goitres at the time of screening were taking dapsone and one patient on dapsone had thyroid antibodies. Thus it seems likely that the increased incidence of thyroid abnormalities in DH may be related to the effects of the sulphonamide on thyroid function.
Published: 1991
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41. Irish society of Gastroenterology

Author: D. P. Murray, R. Foley, M. J. Whelton, K. J. Moriarty, S. Brooks, D. Loft, N. Mpoko, V. Gardner, M. N. Marsh, Fiona M. Stevens, M. Kearns, B. Moran, G. Sutton, M. Taylor, S. J. Karran, M. G. Courtney, M. O’Brien, J. M. McPartlin, M. J. Gibney, J. M. Scott, D. G. Weir, Y. Suzuki, A. Tobin, D. Quinn, A. Whelan, A. O’Morain, R. Waldron, M. O’Riordan, W. O. Kirwan, T. Ryan, J. Lennon, J. Crowe, C. Shinkwin, W. Kirwan, E. J. Mackle, T. G. Parks, L. O’Keefe, D. Lanigan, M. O’Donnell, P. Harte, G. O’Sullivan, D. P. Foley, P. Dunne, P. Dervan, J. P. Crowe, T. O’Callaghan, A. Chua, N. P. Kennedy, P. MacMathuna, J. J. Keating, P. W. N. Keeling, E. Leen, D. McKenna, D. Gilligan, R. Ward, E. Casey, L. Hutchinson, E. C. Sweeney, C. O’Morain, J. S. A. Collins, J. M. Sloan, P. H. Watt, P. W. Hamilton, A. H. G. Love, W. J. Maxwell, D. P. Brennan, J. Huang, G. McDonald, T. Diamond, B. J. Rowlands, J. Keating, E. O’Reilly, P. Burke, G. S. A. McDonald, J. Monson, R. Stephens, O. Corrigan, P. D. Carey, A. Darzi, J. R. T. Monson, W. A. Tanner, F. B. V. Keane, E. Rogers, O. J. McAnena, H. F. Given, P. Keeling, T. DeMeester, David B. Skinner, J. K. Collins, M. O’Donoghue, F. O’Brien, T. O’Donovan, A. Corbett, C. Hahnvaganawong, S. Nolan, J. Collins, J. Murray, B. Hogan, M. Sullivan, J. S. Doyle, P. Butler, F. Walker, P. J. O’Dwyer, J. Minton, H. Enright, S. Patchett, L. O’Connell, D. P. O’Donoghue, N. H. Afdhal, R. P. Cattey, W. J. Hogan, J. F. Helm, R. Ash, D. S. O’Briain, F. O’Malley, and G. Courtney
Subjects: Irish, business.industry, language, engineering, Medicine, General Medicine, Cork, engineering.material, business, language.human_language, Classics
Published: 1991
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42. Irish society of gastroenterology

Author: G. Daly, A. L. Leahy, D. Cottell, T. F. Gorey, D. J. Bouchier-Hayes, M. Barry, P. W. N. Keeling, K. Scott, J. Feely, M. Feeley, C. O’Morain, A. Darzi, W. A. Tanner, F. B. V. Keane, A. Tobin, Y. Suzuki, E. Leen, T. O’Riordan, P. O’Byrne, A. Newland, N. S. Williams, P. Kelly, T. Brady, L. Langrell, F. Feighery, D. G. Weir, C. Fenlon, T. Ryan, J. Hyland, F. Bergin, M. G. Courtney, D. P. Nunes, G. S. A. McDonald, A. Leahy, J. R. T. Monson, J. P. Stevens, C. C. McCombe, M. A. McCarthy, F. McCarthy, F. M. Stevens, J. F. Greally, D. M. Little, R. M. Keane, M. R. Regan, E. Kaye, S. Monkhouse, D. Bouchier-Hayes, M. Lombard, M. Hynes, J. Crow, J. Moran, A. A. Jackson, C. Persaud, S. J. Karran, M. Chir, A. Bomford, R. Poison, R. Williams, D. Nunes, C. P. Kelly, D. Quinn, A. Whelan, C. A. O’Morain, K. C. Trimble, A. G. Shattock, F. M. Mulcahy, J. Deasy, A. P. Clery, N. Noonan, J. Keating, M. Healy, R. O’Rourke, O. Corrigan, R. Henihan, R. Stuart, E. Lean, D. McKerma, T. P. J. Hennessy, M. D. Davies, M. J. Rowan, P. MacMathuna, R. Merriman, J. Crowe, J. Lennon, S. Ahkion, A. Chua, N. Keeling, E. Sinclair, S. Barry, N. Antowan, T. Dinan, I. M. Reid, Elaine Kay, Philippa Marks, E. Kenny, R. Waldron, K. Buchanan, W. Kirwan, M. J. Whelton, S. Patchett, S. Redmond, L. O’Donnell, K. M. Geeney, D. P. O’Donoghue, M. Kerin, V. O’Malley, D. O’Farrell, O. McAnena, J. Callaghan, F. Given, S. J. Kirk, I. V. Allen, J. T. Lawson, T. G. Parks, A. Ali, M. McGuire, C. McCarthy, H. F. Given, H. J. O’Connor, R. Vickers, J. A. C. Buckels, P. MacMaster, E. Elias, J. M. Neuberger, D. S. O’Riordain, P. Losty, P. J. O’Dwyer, and N. J. O’Higgins
Subjects: Irish, business.industry, language, Optometry, Library science, Medicine, General Medicine, business, language.human_language
Published: 1991
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43. Enhanced cholinergic-mediated increase in the pro-inflammatory cytokine IL-6 in irritable bowel syndrome: role of muscarinic receptors

Author: Eamonn Martin Quigley, Timothy G. Dinan, Fergus Shanahan, P. W. N. Keeling, Lucinda V. Scott, John F. Cryan, J. M. Cooney, and Gerard Clarke
Subjects: Drug, Adult, Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, media_common.quotation_subject, Radioimmunoassay, Administration, Oral, Enzyme-Linked Immunosorbent Assay, Muscarinic Antagonists, Irritable Bowel Syndrome, Internal medicine, Muscarinic acetylcholine receptor, medicine, Humans, Receptor, Interleukin 6, Irritable bowel syndrome, media_common, Pain Measurement, Hepatology, biology, Dose-Response Relationship, Drug, business.industry, Interleukin-6, Interleukin-8, Gastroenterology, Middle Aged, medicine.disease, Prognosis, Receptors, Muscarinic, Abdominal Pain, Interleukin-10, Cytokine, Endocrinology, biology.protein, Procyclidine, Cholinergic, Female, Cholinesterase Inhibitors, business, Biomarkers, Pyridostigmine Bromide
Abstract: Irritable bowel syndrome (IBS) is a functional disorder, which has recently been linked to immune activation. We tested the hypothesis that the pro-inflammatory cytokine profile in IBS is driven by the cholinergic system and determined if the responses are mediated by muscarinic receptors.Eighty-eight subjects took part in two studies, 37 IBS patients (Rome II), 14 depressed patients, and 37 healthy volunteers. Eighteen IBS patients had diarrhea predominant IBS, 14 were alternators, and 5 were predominantly constipated. In study 1, blood was drawn for baseline measurement of growth hormone (GH) and cytokines IL-6, IL-8, and IL-10. Pyridostigmine 120 mg was administered orally and further blood sampling took place for 180 min. In study 2, patients with IBS, depressed patients, and healthy subjects underwent the pyridostigmine test on two separate occasions with procyclidine (antimuscarinic) pre-treatment on one test occasion. Both GH and IL-6 were monitored.In study 1, baseline IL-6 (P= 0.003) and IL-8 levels (P= 0.001) were higher in IBS than in controls. Pyridostigmine stimulated the release of IL-6 and GH, but not IL-8 or IL-10; these responses were significantly augmented in IBS patients relative to controls. The IL-6 level following pyridostigmine administration correlated significantly with the symptom score (P0.01). In study 2, IL-6 rose following pyridostigmine in IBS but not depression and procyclidine blocked the rise. The GH response was abolished by procyclidine in all three groups.IBS and major depression are characterized by a pro-inflammatory profile, whereas IBS patients alone exhibit an exaggerated muscarinic receptor-mediated IL-6 response.
Published: 2008

44. Irish society of gastroenterlogy

Author: R. G. P. Watson, B. M. Bhatt, K. G. Porter, C. Doherty, C. McCaughey, T. S. Wilson, D. F. Hughes, J. D. Biggart, C. L. Little, G. C. Corbett-Feeney, M. P. G. Little, C. F. McCarthy, G. Kavanagh, S. Kee, J. McNulty, J. F. Fielding, J. Huang, C. Smyth, J. P. Arbuthnott, N. P. Kennedy, A. Chua, P. W. N. Keeling, J. Lappin, P. Gillen, P. Burke, J. Hyland, A. D. Hill, D. P. O’Donoghue, S. J. McGrath, K. D. Buchanan, C. F. Johnston, K. Barry, D. J. Waldron, P. G. Horgan, M. McGuire, H. F. Given, K. B. Bamford, J. S. A. Collins, T. S. Wilson., S. Patchett, T. O’Riordan, E. Leen, C. Keane, C. O’Morain, D. G. Gilroy, E. J. Mackle, R. A. J. Spence, G. W. Johnson, K. R. O’Sullivan, P. M. Mathias, A. Tobin, C. A. O’Morain, M. E. Carson, F. M. Stevens, M. Bourke, M. Kearns, F. Gannon, D. P. O’Donoghue., S. Ah-Kion, M. O’Driscoll, E. Lee, C. Bolger, P. Kelleher, M. McDonald, P. J. Byrne, T. Gorey, T. P. Hennessy, E. B. Casey, M. MacMahon, B. Hogan, M. O’Sullivan, M. G. Courtney, J. S. Doyle, D. Hamilton, T. Dinan, Fiona M. Stevens, D. Nugent, P. F. Fottrell, J. L. Templeton, M. Madden, M. Elliot, A. Ah Kion, L. N. Yatham, S. Barry, T. Boyle, D. J. Veale, O. Fitzgerald, G. S. A. McDonald, S. R. McCann, D. G. Weir, H. Saleh, and D. Waldron
Subjects: City hospital, Irish, business.industry, language, Medicine, Library science, Optometry, General Medicine, business, language.human_language
Published: 1990
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45. Serotonin Supersensitivity: The Pathophysiologic Basis of Non-Ulcer Dyspepsia?: A Preliminary Report of Buspirone/Prolactin Responses: Preliminary Report

Author: L. N. Yatham, P. W. N. Keeling, Timothy G. Dinan, Andrew Seng Boon Chua, and Siobhan Barry
Subjects: medicine.medical_specialty, business.industry, Gastroenterology, Disease, digestive system diseases, Pathophysiology, Prolactin, Non ulcer dyspepsia, Buspirone, Endocrinology, Internal medicine, Medicine, Serotonin, business, Receptor, 5-HT receptor, medicine.drug
Abstract: Buspirone stimulates central 5-hydroxytryptamine (5HT) receptors and brings about the release of prolactin, and there is evidence to suggest that the extent of prolactin release after a challenge with buspirone is an indicator of the sensitivity of central 5HT receptors. Seventeen patients with a diagnosis of non-ulcer dyspepsia, eight normal healthy volunteers, and six patients with peptic ulcer disease were each given a challenge test of 60 mg buspirone orally, and prolactin release over a 3-h period was monitored. The mean prolactin response was significantly greater in patients with non-ulcer dyspepsia than in healthy controls and peptic ulcer disease patients. The results suggest that central 5HT receptors may be supersensitive in non-ulcer dyspepsia.
Published: 1990
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46. Enhanced Secretion of Prostaglandin E2 by Tissue-Fixed Macrophages in Colonic Carcinoma

Author: F.P. Hogan, Dermot Kelleher, F. J. Bloomfield, P. W. N. Keeling, G.S. MacDonald, J.J. Keating, and W.J. Maxwell
Subjects: medicine.medical_specialty, Leukotriene B4, Zymosan, Gastroenterology, Biology, medicine.disease, Peripheral blood mononuclear cell, chemistry.chemical_compound, Endocrinology, Immune system, chemistry, Internal medicine, medicine, Carcinoma, Macrophage, lipids (amino acids, peptides, and proteins), Arachidonic acid, Prostaglandin E2, medicine.drug
Abstract: Prostaglandin E2 (PGE2) secretion by peripheral blood and tissue-fixed macrophages from patients with colorectal carcinoma was assessed. There was no significant difference between PGE2 production by peripheral blood mononuclear cells between patients with colorectal carcinoma and normal controls. However, secretion of PGE2 by tissue-fixed macrophages from within the colorectal carcinomata in response to opsonised zymosan was significantly higher than in the uninvolved colonic tissue. PGE2 production by tissue-fixed macrophages from within colonic polyps was found to be normal. These results could not be explained on the basis of increased availability of substrate arachidonic acid since addition of excess arachidonic acid resulted in similar findings. The enhanced production of PGE2 correlated with Dukes staging but not the level of differentiation. The production of PGE2 from epithelial cells in response to ionophore A23187 was not significantly enhanced. Leukotriene B4 secretion by intestinal macrophages in response to opsonised zymosan was not significantly elevated in the colonic tumour tissue. Modulation of levels of prostaglandin production within colonic tumours may play a role in the rate of growth and vascularity of these tumours and in the regulation of the local immune response to malignancy.
Published: 1990
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47. Assessment of central noradrenergic functioning in irritable bowel syndrome using a neuroendocrine challenge test

Author: P. W. N. Keeling, Andrew Seng Boon Chua, Stephen Ahkion, Siobhan Barry, and Timothy G. Dinan
Subjects: Adult, Male, Peptic Ulcer, medicine.medical_specialty, Personality Inventory, Adrenergic receptor, Colonic Diseases, Functional, Disease, Growth hormone, Norepinephrine, Internal medicine, Desipramine, medicine, Humans, Receptor, Irritable bowel syndrome, business.industry, Neuroendocrine challenge, Middle Aged, medicine.disease, Receptors, Adrenergic, Psychiatry and Mental health, Clinical Psychology, Endocrinology, Growth Hormone, Female, Monoamine reuptake inhibitor, Gastrointestinal Motility, business, medicine.drug
Abstract: Desipramine, the monoamine reuptake inhibitor, acts predominantly on noradrenergic neurones, and via alpha-2 receptors brings about the release of growth hormone in normal healthy subjects. Thirteen patients with a diagnosis of irritable bowel syndrome, 10 normal controls and eight patients with peptic ulcer disease were each given a challenge test of desipramine 1 mg/kg body weight. Growth hormone release over a 3 h period was monitored. A blunted response was defined as a failure of growth hormone levels to rise at least 5 mU/1 above baseline. Of the 13 patients with irritable bowel syndrome 11 showed such a blunting. The results suggest abnormal central alpha-2 receptor functioning in irritable bowel syndrome.
Published: 1990
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48. Superiority of anti-reflux stent compared with conventional stents in the palliative management of patients with cancer of the lower esophagus and esophago-gastric junction: results of a randomized clinical trial

Author: C. Power, J. Moore, John V. Reynolds, T. Fitzgerald, P. J. Byrne, P. W. N. Keeling, Narayanasamy Ravi, and K. Lim
Subjects: Adult, Male, medicine.medical_specialty, Esophageal Neoplasms, medicine.medical_treatment, Gastroenterology, law.invention, Randomized controlled trial, Quality of life, law, Internal medicine, Surveys and Questionnaires, medicine, Humans, Aged, Aged, 80 and over, business.industry, Palliative Care, Reflux, Cancer, Stent, General Medicine, Equipment Design, Esophageal cancer, Hydrogen-Ion Concentration, Middle Aged, medicine.disease, Dysphagia, Surgery, Cohort, Gastroesophageal Reflux, Female, Stents, Esophagogastric Junction, medicine.symptom, business, Follow-Up Studies
Abstract: SUMMARY. Palliation of inoperable esophageal cancer with covered stents aims to relieve progressive dysphagia and improve health-related quality of life (HRQoL). Introducing a stent across the esophagogastric junction in lower third tumors may predispose to unchecked gastro-esophageal reflux (GER). Esophageal stents incorporating an anti-reflux valve have been introduced to address this problem. We prospectively compared an anti-reflux stent with a standard stent in the palliation of inoperable lower third esophageal tumors. Forty-nine consecutive patients with malignant dysphagia were randomized to receive a standard (n = 25, group 1) or an anti-reflux stent (n = 24, group 2). HRQoL was assessed before stenting, at 1 week and at 2 months, utilizing European Organization for Research and Treatment of Cancer questionnaires QLQ-C30, QLQ-OES24 and reflux questionnaires. Esophageal pH testing was performed within 1 week of the stent insertion. Detailed statistical analysis was employed to assess general QoL, symptoms and pH scores in both groups. Both groups reported significantly improved QoL, health and dysphagia scores at 1 week and 2 months after stenting. Group 2 patients reported significantly (P
Published: 2007

49. Comparison of ERCP procedures performed in a tertiary referral centre in 1996 and 2002

Author: Nasir Mahmud, J Groarke, R Cooney, P. W. N. Keeling, and Susan McKiernan
Subjects: medicine.medical_specialty, business.industry, Tertiary referral centre, General surgery, Gastroenterology, Medicine, business
Published: 2006
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50. Central serotonergic and noradrenergic receptors in functional dyspepsia

Author: Timothy G. Dinan, P. W. N. Keeling, Siobhain M. O'Mahony, and Andrew Seng Boon Chua
Subjects: Central Nervous System, medicine.medical_specialty, Abdominal pain, Sympathetic nervous system, Serotonin, Central nervous system, Sensory system, Biology, Serotonergic, Organic disease, Autonomic Nervous System, chemistry.chemical_compound, Norepinephrine, Internal medicine, medicine, Humans, Topic Highlight, Dyspepsia, Neurotransmitter, Neurotransmitter Agents, Psychotropic Drugs, Gastroenterology, General Medicine, Receptors, Adrenergic, Serotonin Receptor Agonists, Gastrointestinal Tract, Autonomic nervous system, Endocrinology, medicine.anatomical_structure, chemistry, Receptors, Serotonin, medicine.symptom, Gastrointestinal Motility, Neuroscience
Abstract: Functional dyspepsia is a symptom complex characterised by upper abdominal discomfort or pain, early satiety, motor abnormalities, abdominal bloating and nausea in the absence of organic disease. The central nervous system plays an important role in the conducting and processing of visceral signals. Alterations in brain processing of pain, perception and affective responses may be key factors in the pathogenesis of functional dyspepsia. Central serotonergic and noradrenergic receptor systems are involved in the processing of motor, sensory and secretory activities of the gastrointestinal tract. Visceral hypersensitivity is currently regarded as the mechanism responsible for both motor alterations and abdominal pain in functional dyspepsia. Some studies suggest that there are alterations in central serotonergic and noradrenergic systems which may partially explain some of the symptoms of functional dyspepsia. Alterations in the autonomic nervous system may be implicated in the motor abnormalities and increases in visceral sensitivity in these patients. Noradrenaline is the main neurotransmitter in the sympathetic nervous system and again alterations in the functioning of this system may lead to changes in motor function. Functional dyspepsia causes considerable burden on the patient and society. The pathophysiology of functional dyspepsia is not fully understood but alterations in central processing by the serotonergic and noradrenergic systems may provide plausible explanations for at least some of the symptoms and offer possible treatment targets for the future.
Published: 2006

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