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2. Epidemiological characteristics, management and early outcomes of acute coronary syndromes in Greece: The PHAETHON study

Author

G. Andrikopoulos, D. Terentes-Printzios, S. Tzeis, C. Vlachopoulos, C. Varounis, N. Nikas, J. Lekakis, D. Stakos, S. Lymperi, D. Symeonidis, D. Chrissos, C. Kyrpizidis, D. Alexopoulos, S. Zombolos, S. Foussas, Α. Κranidis, Κ. Oikonomou, V. Vasilikos, P. Andronikos, Α. Dermitzakis, D. Richter, N. Fragakis, I. Styliadis, S. Mavridis, C. Stefanadis, and P. Vardas

Subjects
Acute coronary syndromes, Myocardial infarction, Epidemiology, Prognosis, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Introduction: In view of recent therapeutic breakthroughs in acute coronary syndromes (ACS) and essential demographic and socioeconomic changes in Greece, we conducted the prospective, multi-center, nationwide PHAETHON study (An Epidemiological Cohort Study of Acute Coronary Syndromes in the Greek Population) that aimed to recruit a representative cohort of ACS patients and examine current management practices and patient prognosis. Methods: The PHAETHON study was conducted from May 2012 to February 2014. We enrolled 800 consecutive ACS patients from 37 hospitals with a proportional representation of all types of hospitals and geographical areas. Patients were followed for a median period of 189 days. Outcome was assessed with a composite endpoint of death, myocardial infarction, stroke, urgent revascularization and urgent hospitalization for cardiovascular causes. Results: The mean age of patients was 62.7 years (78% males). The majority of patients (n=411, 51%) presented with ST-elevation myocardial infarction (STEMI), whereas 389 patients presented with NSTEMI (n=303, 38%) or UA (n=86, 11%). Overall, 58.8% of the patients had hypertension, 26.5% were diabetic, 52.5% had dyslipidemia, 71.1% had a smoking history (current or past), 25.8% had a family history of coronary artery disease (CAD) and 24.1% had a prior history of CAD. In STEMI patients, 44.5% of patients were treated with thrombolysis, 38.9% underwent a coronary angiogram (34.1% were treated with primary percutaneous coronary intervention) and 16.5% did not receive urgent treatment. The pain-to-door time was 169 minutes. During hospitalization, 301 (38%) patients presented one or more complications, and 13 died (1.6%). During follow-up, 99 (12.6%) patients experienced the composite endpoint, and 21 died (2.7%). Conclusions: The PHAETHON study provided valuable insights into the epidemiology, management and outcome of ACS patients in Greece. Management of ACS resembles the management observed in other European countries. However, several issues still to be addressed by public authorities for the timely and proper management of ACS.

Published
2016
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3. CONFLICT OF INTEREST POLICIES AND DISCLOSURE REQUIREMENTS AMONG EUROPEAN SOCIETY OF CARDIOLOGY NATIONAL CARDIOVASCULAR JOURNALS

Author

F. Alfonso, A. Timmis, F. J. Pinto, G. Ambrosio, H. Ector, P. Kulakowski, and P. Vardas

Subjects
конфликт интересов, раскрытие, редакционная этика, журналы, Therapeutics. Pharmacology, RM1-950, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Раскрытие потенциального конфликта интересов (КИ) в биомедицинских журналах призвано обеспечить надежность и прозрачность научного процесса. Тем не менее, большинство журналов не уделяют должного внимания систематическому, последовательному решению проблемы раскрытия КИ. В последние годы, благодаря совместным усилиям редакторов биомедицинских журналов, были разработаны единые механизмы уведомления о КИ. В настоящей статье подробно описывается точка зрения редакторов биомедицинских журналов на проблему КИ. Кроме того, представлены результаты выполненного с помощью стандартизованного вопросника исследования, которое оценивало существующие требования в отношении раскрытия КИ и их практическое внедрение в национальных кардиологических журналах Европейского общества кардиологов.

Published
2015
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4. Identifying the needs for competency-based education in Europe: a needs assessment of cardiologists across 52 countries

Author

S. Murray, C. Carrera, P. Lazure, P. Vardas, J. L. Zamorano, P. Kearney, L. Goncalves, K. Fox, and A. Vahanian

Subjects
European Society of Cardiology, needs assessment, cardiology, collaboration, communication, skills, education, Special aspects of education, LC8-6691, Medicine (General), R5-920
Abstract

Objective: This international needs assessment was mandated by the European Society of Cardiology (ESC) to obtain an in-depth understanding of the current gaps and challenges of European cardiology professionals, with the aim to provide evidence for the development of needs-driven educational and professional development activities. Methods: This ethics-approved needs assessment was conducted among cardiologists from all sub-specialties across 56 countries of Europe and the Mediterranean basin. A mixed-methods research approach was used, combining qualitative in-depth interviews and focus groups with a quantitative survey. Results: Seventy-four (74) cardiologists participated in the qualitative phase and 866 completed the survey. Respondents represented 52 of the 56 targeted countries. Three themes were identified: 1) Challenges in the clinical decision-making process, 2) Challenges in establishing the patient-physician relationship, and 3) Sub-optimal team communication and collaboration. Specific gaps and causalities related to each challenge were found. Although most of the gaps were common across countries and sub-specialties, some significant differences were noted. Conclusion: The findings of this needs assessment indicate gaps and challenges in clinical practice across countries and across sub-specialities. Taking cardiology as an example, this study identifies clear areas of focus, especially around issues of collaboration and communication, for targeted competency-based education in Europe.

Published
2017
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5. CONFLICT OF INTEREST POLICIES AND DISCLOSURE REQUIREMENTS AMONG EUROPEAN SOCIETY OF CARDIOLOGY NATIONAL CARDIOVASCULAR JOURNALS

Author

F. Alfonso, A. Timmis, F. J. Pinto, G. Ambrosio, H. Ector, P. Kulakowski, and P. Vardas

Subjects
конфликт интересов, раскрытие, редакционная этика, журналы, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Раскрытие потенциального конфликта интересов (КИ) в биомедицинских журналах призвано обеспечить надежность и прозрачность научного процесса. Тем не менее, большинство журналов не уделяют должного внимания систематическому, последовательному решению проблемы раскрытия КИ. В последние годы, благодаря совместным усилиям редакторов биомедицинских журналов, были разработаны единые механизмы уведомления о КИ. В настоящей статье подробно описывается точка зрения редакторов биомедицинских журналов на проблему КИ. Кроме того, представлены результаты выполненного с помощью стандартизованного вопросника исследования, которое оценивало существующие требования в отношении раскрытия КИ и их практическое внедрение в национальных кардиологических журналах Европейского Общества Кардиологов.

Published
2012

10. Improving the Performance and Resilience of MPI Parallel Jobs with Topology and Fault-Aware Process Placement

Author

Vardas, Ioannis, Ploumidis, Manolis, and Marazakis, Manolis

Subjects
Computer Science - Distributed, Parallel, and Cluster Computing, C.4
Abstract

HPC systems keep growing in size to meet the ever-increasing demand for performance and computational resources. Apart from increased performance, large scale systems face two challenges that hinder further growth: energy efficiency and resiliency. At the same time, applications seeking increased performance rely on advanced parallelism for exploiting system resources, which leads to increased pressure on system interconnects. At large system scales, increased communication locality can be beneficial both in terms of application performance and energy consumption. Towards this direction, several studies focus on deriving a mapping of an application's processes to system nodes in a way that communication cost is reduced. A common approach is to express both the application's communication patterns and the system architecture as graphs and then solve the corresponding mapping problem. Apart from communication cost, the completion time of a job can also be affected by node failures. Node failures may result in job abortions, requiring job restarts. In this paper, we address the problem of assigning processes to system resources with the goal of reducing communication cost while also taking into account node failures. The proposed approach is integrated into the Slurm resource manager. Evaluation results show that, in scenarios where few nodes have a low outage probability, the proposed process placement approach achieves a notable decrease in the completion time of batches of MPI jobs. Compared to the default process placement approach in Slurm, the reduction is 18.9% and 31%, respectively for two different MPI applications., Comment: 21 pages, 8 figures, added Acknowledgements section

Published
2020

11. The Online Min-Sum Set Cover Problem

Author

Fotakis, Dimitris, Kavouras, Loukas, Koumoutsos, Grigorios, Skoulakis, Stratis, and Vardas, Manolis

Subjects
Computer Science - Data Structures and Algorithms
Abstract

We consider the online Min-Sum Set Cover (MSSC), a natural and intriguing generalization of the classical list update problem. In Online MSSC, the algorithm maintains a permutation on $n$ elements based on subsets $S_1, S_2, \ldots$ arriving online. The algorithm serves each set $S_t$ upon arrival, using its current permutation $\pi_{t}$, incurring an access cost equal to the position of the first element of $S_t$ in $\pi_{t}$. Then, the algorithm may update its permutation to $\pi_{t+1}$, incurring a moving cost equal to the Kendall tau distance of $\pi_{t}$ to $\pi_{t+1}$. The objective is to minimize the total access and moving cost for serving the entire sequence. We consider the $r$-uniform version, where each $S_t$ has cardinality $r$. List update is the special case where $r = 1$. We obtain tight bounds on the competitive ratio of deterministic online algorithms for MSSC against a static adversary, that serves the entire sequence by a single permutation. First, we show a lower bound of $(r+1)(1-\frac{r}{n+1})$ on the competitive ratio. Then, we consider several natural generalizations of successful list update algorithms and show that they fail to achieve any interesting competitive guarantee. On the positive side, we obtain a $O(r)$-competitive deterministic algorithm using ideas from online learning and the multiplicative weight updates (MWU) algorithm. Furthermore, we consider efficient algorithms. We propose a memoryless online algorithm, called Move-All-Equally, which is inspired by the Double Coverage algorithm for the $k$-server problem. We show that its competitive ratio is $\Omega(r^2)$ and $2^{O(\sqrt{\log n \cdot \log r})}$, and conjecture that it is $f(r)$-competitive. We also compare Move-All-Equally against the dynamic optimal solution and obtain (almost) tight bounds by showing that it is $\Omega(r \sqrt{n})$ and $O(r^{3/2} \sqrt{n})$-competitive., Comment: A preliminary version of this article appeared in the Proceedings of the 47th International Colloquium on Automata, Languages and Programming (ICALP 2020)

Published
2020

23. Survivin and caspases serum protein levels and survivin variants mRNA expression in sepsis

Author

Miliaraki, Marianna, Briassoulis, Panagiotis, Ilia, Stavroula, Polonifi, Aikaterini, Mantzourani, Marina, Briassouli, Efrossini, Vardas, Konstantinos, Nanas, Serafim, Pistiki, Aikaterini, Theodorakopoulou, Maria, Tavladaki, Theonymfi, Spanaki, Anna Maria, Kondili, Eumorfia, Dimitriou, Helen, Tsiodras, Sotirios, Georgopoulos, Dimitrios, Armaganidis, Apostolos, Daikos, George, and Briassoulis, George

Published
2021
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24. The Society of Thoracic Surgeons 2023 Clinical Practice Guidelines for the Surgical Treatment of Atrial Fibrillation.

Author

Wyler von Ballmoos, Moritz C., Hui, Dawn S., Mehaffey, J. Hunter, Malaisrie, S. Chris, Vardas, Panos N., Gillinov, A. Marc, Sundt, Thoralf M., and Badhwar, Vinay

Abstract

The Society of Thoracic Surgeons 2023 Clinical Practice Guidelines for the Surgical Treatment of Atrial Fibrillation incorporate the most recent evidence for surgical ablation and left atrial appendage occlusion in different clinical scenarios. Substantial new evidence regarding the risks and benefits of surgical left atrial appendage occlusion and the long-term benefits of surgical ablation has been produced in the last 5 years. Compared with the 2017 clinical practice guideline, the current update has an emphasis on surgical ablation in first-time, nonemergent cardiac surgery and its long-term benefits, an extension of the recommendation to perform surgical ablation in all patients with atrial fibrillation undergoing first-time, nonemergent cardiac surgery, and a new class I recommendation for left atrial appendage occlusion in all patients with atrial fibrillation undergoing first-time, nonemergent cardiac surgery. Further guidance is provided for patients with structural heart disease and atrial fibrillation being considered for transcatheter valve repair or replacement, as well as patients in need of isolated left atrial appendage management who are not candidates for surgical ablation. The importance of a multidisciplinary team assessment, treatment planning, and long-term follow-up are reiterated in this clinical practice guideline with a class I recommendation, along with the other recommendations from the 2017 guidelines that remained unchanged in their class of recommendation and level of evidence. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Allergic rhinitis: Review of the diagnosis and management: South African Allergic Rhinitis Working Group.

Author

Richards, G. A., McDonald, M., Gray, C. L., de Waal, P., Friedman, R., Hockman, M., Karabus, S. J., Lodder, C. M., Mabelane, T., Mosito, S. M., Nanan, A., Peter, J. G., Quitter, T. H. C., Seedat, R., den Berg, Svan, van Niekerk, A., Vardas, E., and Feldman, C.

Subjects
RHINITIS treatment, ALLERGENS, ADRENOCORTICAL hormones, OTITIS media, PHYSIOLOGIC salines, DIFFERENTIAL diagnosis, DISEASE management, IMMUNOTHERAPY, SINUSITIS, ALLERGIC rhinitis, SEASONAL variations of diseases, RHINITIS, ANTIHISTAMINES, QUALITY of life, DISEASE susceptibility, ASTHMA, COMORBIDITY
Abstract

Background: Allergic rhinitis (AR) has a significant impact on the community as a whole with regard to quality of life and its relationship to allergic multi-morbidities. Appropriate diagnosis, treatment and review of the efficacy of interventions can ameliorate these effects. Yet, the importance of AR is often overlooked, and appropriate therapy is neglected. The availability of effective medications and knowledge as to management are often lacking in both public and private health systems. Methods: This review is based on a comprehensive literature search and detailed discussions by the South African Allergic Rhinitis Working Group (SAARWG). Results: The working group provided up-to-date recommendations on the epidemiology, pathology, diagnosis and management of AR, appropriate to the South African setting. Conclusion: Allergic rhinitis causes significant, often unappreciated, morbidity. It is a complex disease related to an inflammatory response to environmental allergens. Therapy involves education, evaluation of allergen sensitisation, pharmacological treatment, allergen immunotherapy (AIT) and evaluation of the success of interventions. Regular use of saline; the important role of intranasal corticosteroids, including those combined with topical antihistamines and reduction in the use of systemic steroids are key. Practitioners should have a thorough knowledge of associated morbidities and the need for specialist referral. Contribution: This review summarises the latest developments in the diagnosis and management of AR such that it is a resource that allows easy access for family practitioners and specialists alike. [ABSTRACT FROM AUTHOR]

Published
2024

32. Increased glucocorticoid receptor expression in sepsis is related to heat shock proteins, cytokines, and cortisol and is associated with increased mortality

Author

Vardas, Konstantinos, Ilia, Stavroula, Sertedaki, Amalia, Charmandari, Evangelia, Briassouli, Efrossini, Goukos, Dimitris, Apostolou, Kleovoulos, Psarra, Katerina, Botoula, Efthimia, Tsagarakis, Stylianos, Magira, Eleni, Routsi, Christina, Stratakis, Constantine A., Nanas, Serafim, and Briassoulis, George

Published
2017
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36. Detection of left ventricular hypertrophy on the ECG through machine learning with a focus on obesity

Author

E Angelaki, M Marketou, G Barmparis, S Maragkoudakis, E Peponaki, P Kalomoirakis, S Zervakis, K Fragkiadakis, A Plevritaki, T Pateromichelakis, P Vardas, G Kochiadakis, and G Tsironis

Subjects
General Engineering, General Earth and Planetary Sciences, Cardiology and Cardiovascular Medicine, General Environmental Science
Abstract

Background Cardiac remodeling, an important aspect of cardiovascular disease (CVD) progression, is emerging as a significant therapeutic target. The electrocardiogram (ECG) is of paramount importance in the initial evaluation of a patient. However, the ECG is not a sensitive method of detecting left ventricular hypertrophy (LVH), and as far as we know, it cannot detect changes in left ventricular geometry (LVG) at early stages, especially before LVH is present. Its sensitivity is particularly low for obese patients. Purpose To use a machine learning (ML) classifier to detect abnormal LVG from ECG parameters/markers, even before it becomes LVH, and to propose some indicative markers useful for practitioners. We also looked at the results of our model for obese patients to test the markers in this population. Methods We enrolled consecutive subjects, aged 30 years or older (mean age: 61.6±12 years old) with and without essential hypertension and no indications of CVD. All patients underwent a full echocardiographic evaluation and were classified into 2 groups; those with normal geometry (NG) vs. those with concentric remodeling (CR) or LVH defined as concentric hypertrophy (CH) and eccentric hypertrophy (EH). Abnormal LVG was identified as increased relative wall thickness (RWT) and/or left ventricular mass index (LVMi). We analyzed the EKG waveforms deduced to single beat averages for each lead using custom software and extracted 70 markers. We then trained a Random Forest machine learning model to classify subjects with abnormal LVG and calculated SHAP values to perform feature importance and interaction. Results After screening 1120 individuals, we enrolled 594 subjects, aged 30 years or older (mean age: 61.6±12 years old). The percentage of women was 56.5%, while 71.3% of all patients were hypertensive. Hypertension, age, body mass index divided by the Sokolow-Lyon voltage (BMI/S-L), QRS-T angle, and QTc duration were among the most important parameters (Figure, left panel) identified by the model as being predictive of abnormal LVG (AUC/ROC = 0.84, sensitivity = 0.94, specificity 0.61). Specifically for obese patients, whose prevalence in our population was 60.3%, our model performed well (sensitivity = 0.71, specificity = 0.92. When we tried our model without the the BMI/S-L parameter, the specificity dropped to 0.88. We also found that a cut-off point of 18 for the BMI/S-L marker predicted the patients who were more probable to have developed abnormal LVG. Conclusions This study is the first to demonstrate the promising potential of ML modeling for the efficient and cost-effective diagnostic screening of abnormal LVG and cardiac remodeling through ECG. We found specific clinical and ECG parameters that can predict early pathological changes of LVG in patients without established CVD and detect the population who will benefit from a detailed echocardiographic evaluation. Funding Acknowledgement Type of funding sources: None.

Published
2022
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37. Atrial Fibrillation: Pathogenesis, Predisposing Factors, and Genetics

Author

Marios Sagris, Emmanouil P. Vardas, Panagiotis Theofilis, Alexios S. Antonopoulos, Evangelos Oikonomou, and Dimitris Tousoulis

Subjects
QH301-705.5, Review, Catalysis, Inorganic Chemistry, Risk Factors, Mediterranean diet, Humans, oxidative stress, Gene Regulatory Networks, Genetic Predisposition to Disease, genetics, atrial fibrillation, Physical and Theoretical Chemistry, Biology (General), Life Style, Molecular Biology, QD1-999, Spectroscopy, pathogenesis, Organic Chemistry, Health Care Costs, General Medicine, Computer Science Applications, Chemistry, diets, predisposing factors
Abstract

Atrial fibrillation (AF) is the most frequent arrhythmia managed in clinical practice, and it is linked to an increased risk of death, stroke, and peripheral embolism. The Global Burden of Disease shows that the estimated prevalence of AF is up to 33.5 million patients. So far, successful therapeutic techniques have been implemented, with a high health-care cost burden. As a result, identifying modifiable risk factors for AF and suitable preventive measures may play a significant role in enhancing community health and lowering health-care system expenditures. Several mechanisms, including electrical and structural remodeling of atrial tissue, have been proposed to contribute to the development of AF. This review article discusses the predisposing factors in AF including the different pathogenic mechanisms, sedentary lifestyle, and dietary habits, as well as the potential genetic burden.

Published
2022

38. Allergic rhinitis: review of the diagnosis and management: South African Allergic Rhinitis Working Group.

Author

Richards, G. A., McDonald, M., Gray, C. L., de Waal, P., Friedman, R., Hockman, M., Karabus, S. J., Lodder, C. M., Mabelane, T., Mosito, S. M., Nanan, A., Peter, J. G., Quitter, T. H. C., Seedat, R., van den Berg, S., van Niekerk, A., Vardas, E., and Feldman, C.

Subjects
ALLERGIC rhinitis, INTRANASAL medication, IMMUNOTHERAPY, CORTICOSTEROIDS, EPIDEMIOLOGY
Abstract

Background: Allergic rhinitis (AR) has a significant impact on the community as a whole with regard to quality of life and its relationship to allergic multi-morbidities. Appropriate diagnosis, treatment and review of the efficacy of interventions can ameliorate these effects. Yet, the importance of AR is often overlooked, and appropriate therapy is neglected. The availability of effective medications and knowledge as to management are often lacking in both public and private health systems. Methods: This review is based on a comprehensive literature search and detailed discussions by the South African Allergic Rhinitis Working Group (SAARWG). Results: The working group provided up-to-date recommendations on the epidemiology, pathology, diagnosis and management of AR, appropriate to the South African setting. Conclusion: Allergic rhinitis causes significant, often unappreciated, morbidity. It is a complex disease related to an inflammatory response to environmental allergens. Therapy involves education, evaluation of allergen sensitisation, pharmacological treatment, allergen immunotherapy (AIT) and evaluation of the success of interventions. Regular use of saline; the important role of intranasal corticosteroids (INCS), including those combined with topical antihistamines and reduction in the use of systemic steroids are key. Practitioners should have a thorough knowledge of associated morbidities and the need for specialist referral. Contribution: This review summarises the latest developments in the diagnosis and management of AR such that it is a resource that allows easy access for family practitioners and specialists alike. [ABSTRACT FROM AUTHOR]

Published
2023

41. Artificial intelligence-based opportunistic screening for the detection of arterial hypertension through ECG signals

Author

E Angelaki, G Barmparis, G Kochiadakis, S Maragkoudakis, A Tsiavos, P Kalomoirakis, E Kampanieris, S Zervakis, A Plevritaki, E Savva, S Kassotakis, P Vardas, G Tsironis, and M Marketou

Subjects
Cardiology and Cardiovascular Medicine
Abstract

Background Hypertension is a major risk factor for cardiovascular disease (CVD) which often escapes the diagnosis or should be confirmed by several office visits. The electrocardiogram (ECG) is one of the most widely used diagnostic tools and could be of paramount importance in patients' initial evaluation. Purpose To detect whether a person is hypertensive using features from the ECG, as well as basic anthropometric features such as age, sex, and body mass index (BMI). Methods We used machine learning (ML) techniques based features derived from the electrocardiogram for detecting hypertension in a population without CVD. We enrolled 1091 subjects who were classified into hypertensive and normotensive group. We trained 3 ML models, specifically logistic regression, k-nearest-neighbors, and random forest (RF), to predict the existence of hypertension in patients based only on a few basic clinical parameters and ECG-derived features. We also calculated Shapley additive explanations (SHAP), a sophisticated feature importance analysis, to interpret each feature's role in the random forest's predictions. Results Our RF model was able to distinguish hypertensive from normotensive patients with accuracy 84.2%, specificity 66.7%, sensitivity 91.4%, and area under the receiver-operating curve 0.86. Age, BMI, BMI-adjusted Cornell criteria (BMI multiplied by RaVL+SV3), R wave amplitude in aVL, and BMI-modified Sokolow-Lyon voltage (BMI divided by SV1+RV5), were the most important anthropometric and ECG-derived features in terms of the success of our model. Figure 1 shows the results in detecting hypertension by the Random Forest. Conclusions Our ML algorithm is effective in the detection of hypertension in patients using ECG-derived and basic anthropometric criteria. Our findings open new horizon in the detection of many undiagnosed hypertensive individuals who have an increased cardiovascular disease risk. Funding Acknowledgement Type of funding sources: None.

Published
2022
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43. ESICM LIVES 2016: part two: Milan, Italy. 1–5 October 2016

Author

Sivakumar, S., Taccone, F. S., Desai, K. A., Lazaridis, C., Skarzynski, M., Sekhon, M., Henderson, W., Griesdale, D., Chapple, L., Deane, A., Williams, L., Strickland, R., Lange, K., Heyland, D., Chapman, M., Rowland, M. J., Garry, P., Westbrook, J., Corkill, R., Antoniades, C. A., Pattinson, K. T., Fatania, G., Strong, A. J., Myers, R. B., Lazaridis, C., Jermaine, C. M., Robertson, C. S., Rusin, C. G., Hofmeijer, J., Sondag, L., Tjepkema-Cloostermans, M. C., Beishuizen, A., Bosch, F. H., van Putten, M. J. A. M., Carteron, L., Patet, C., Solari, D., Oddo, M., Ali, M. A., Dias, C., Almeida, R., Vaz-Ferreira, A., Silva, J., Monteiro, E., Cerejo, A., Rocha, A. P., Elsayed, A. A., Abougabal, A. M., Beshey, B. N., Alzahaby, K. M., Pozzebon, S., Ortiz, A. Blandino, Cristallini, S., Lheureux, O., Brasseur, A., Vincent, J. L., Creteur, J., Taccone, F. S., Hravnak, M., Yousef, K., Chang, Y., Crago, E., Friedlander, R. M., Abdelmonem, S. A., Tahon, S. A., Helmy, T. A., Meligy, H. S., Puig, F., Dunn-Siegrist, I., Pugin, J., Gupta, S., Govil, D., Srinivasan, S., Patel, S. J., N, J. K., Gupta, A., Tomar, D. S., Shafi, M., Harne, R., Arora, D. P., Talwar, N., Mazumdar, S., Papakrivou, E. E., Makris, D., Manoulakas, E., Tsolaki, B., Karadodas, B., Zakynthinos, E., Garcia, I. Palacios, Martin, A. Diaz, Encinares, V. Sanchez, Ibañez, M. Pachón, Montero, J. Garnacho, Labrador, G., Cangueiro, T. Cebrero, Poulose, V., Koh, J., Kam, J. W., Yeter, H., Kara, A., Aktepe, O., Topeli, A., Tsolakoglou, I., Intas, G., Stergiannis, P., Kolaros, A. A., Chalari, E., Athanasiadou, E., Martika, A., Fildisis, G., Faivre, V., Mengelle, C., Favier, B., Payen, D., Poppe, A., Winkler, M. S., Mudersbach, E., Schreiber, J., Wruck, M. L., Schwedhelm, E., Kluge, S., Zöllner, C., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., la Torre, A. García-de, de la Torre-Prados, M. V., Tsvetanova-Spasova, T., Nuevo-Ortega, P., Rueda-Molina, C., Fernández-Porcel, A., Camara-Sola, E., Salido-Díaz, L., García-Alcántara, A., Tavladaki, T., Spanaki, A. M., Dimitriou, H., Kondili, E., Choulaki, C., Meleti, D. E., Kafetzopoulos, D., Georgopoulos, D., Briassoulis, G., Suberviola, B., Riera, J., Rellan, L., Sanchez, M., Robles, J. C., Lopez, E., Vicente, R., Miñambres, E., Santibañez, M., Le Guen, M., Moore, J., Mason, N., Windpassinger, M., Plattner, O., Mascha, E., Sessler, D. I., Research, Outcomes, Melia, U., Fontanet, J., van den Berg, J. P., Struys, M. M. R. F., Vereecke, H. E. M., Jensen, E. W., Rood, P. J. T., van de Schoor, F., van Tertholen, K., Pickkers, P., van den Boogaard, M., Beardow, Z. J., Redhead, H., Paramasivam, K., Numan, T., van den Boogaard, M., Kamper, A. M., Rood, P., Peelen, L. M., Zeman, P. M., Slooter, A. J., van Ewijk, C. E., Jacobs, G. E., Girbes, A. R. J., Myatra, S. N., Harish, M. M., Prabu, N. R., Siddiqui, S., Kulkarni, A. 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Iglesias, Mittelbrum, C. Ponte, Albaiceta, G. Muñiz, Ampatzidou, F., Sileli, M., Kehagioglou, G., Madesis, A., Karaiskos, T., Moursia, C., Maleoglou, H., Leleki, K., Drossos, G., Uz, Z., Ince, Y., Papatella, R., Bulent, E., Guerci, P., Ince, C., De Mol, B., Vicka, V., Gineityte, D., Ringaitiene, D., Norkiene, I., Sipylaite, J., Möller, C., Fleischmann, C., Thomas-Rueddel, D. O., Vlasakov, V., Rochwerg, B., Theurer, P., Gattinoni, L., Reinhart, K., Hartog, C. S., Pérez, A. González, Al Sibai, J. Zanabili, Camblor, P. Martinez, Fernandez, P. Alvarez, Gala, J. M. García, Guisasola, J. Silba, Albaiceta, G. Muñiz, Tamura, T., Yatabe, T., Miyajima, I., Yamashita, K., Yokoyama, M., Ampatzidou, F., Kehagioglou, G., Dalampini, E., Nastou, M., Baddour, A., Ignatiadis, A., Asteri, T., Drossos, G., Hathorn, K. E., Purtle, S. W., Horkan, C. M., Gibbons, F. K., Christopher, K. B., Viana, M. V., Tonietto, T. A., Gross, L. A., Costa, V. L., Tavares, A. L. J., Lisboa, B. O., Moraes, R. B., Vieira, S. R., Viana, L. V., Azevedo, M. J., Ceniccola, G. D., Pequeno, R. S. F., Holanda, T. P., Mendonça, V. S., Araújo, W. M. C., Carvalho, L. S. F., Segaran, E., Vickers, L., Brinchmann, K., Wignall, I., Rubulotta, F., De Brito-Ashurst, I., del Olmo, R., Esteban, M. J., Vaquerizo, C., Carreño, R., Gálvez, V., Kaminsky, G., Nieto, B., Fuentes, M., De la Torre, M. A., Torres, E., Alonso, A., Velayos, C., Saldaña, T., Escribá, A., GRIP, J., Kölegård, R., Sundblad, P., Rooyackers, O., Naser, Ben, Jaziri, F., Jazia, A. Ben, Barghouth, M., Hentati, O., Skouri, W., El Euch, M., Mahfoudhi, M., Turki, S., Abdelghni, K. Ben, Abdallah, Ben, Maha, B. N. M., Cánovas, J., Sotos, F., López, A., Lorente, M., Burruezo, A., Torres, D., Polok, K., Włudarczyk, A., Górka, J., Hałek, A., Musiał, J., Szczeklik, W., Jazia, A. Ben, Jaziri, F., Bargouth, M., Bennasr, M., Turki, S., Abdelghani, K. Ben, Abdallah, T. Ben, de Grooth, H. J., Geenen, I. L., Parienti, J. J., Straaten, H. M. Oudemans-van, Shum, H. P., King, H. S., Chan, K. C., Yan, W. W., Londoño, J. Gonzalez, Cardenas, C. Lorencio, Pedrosa, M. Morales, Gubianas, C. Murcia, Bertolin, C. Fuster, Batllori, N. Vila, Sirvent, J. M., Wykes, K., Jack, J., Morgan, P., Mukhopadhyay, A., Chan, H. Y., Kowitlawakul, Y., Remani, D., Leong, C. S. F., Henry, C. J., Puthucheary, Z. A., Mendsaikhan, N., Begzjav, T., Lundeg, G., Dünser, M., Espinoza, E. D. Valenzuela, Welsh, S. P., Motta, M. F., Guerra, E., Zerpa, M. C. l., Zechner, F., Furche, M., Berdaguer, F., Birri, P. N. Rubatto, Risso-Vazquez, A., Dubin, A., Masevicius, F. D., Greaney, D., Magee, A., Fitzpatrick, G., Lugo-Cob, R. G., Sánchez-Hurtado, L. A., Arvizu-Tachiquín, P. C., Tejeda-Huezo, B. C., Cano-Oviedo, A. A., Baltazar-Torres, J. A., Aydogan, M. S., Togal, T., Taha, A., Chai, H. Z., Kam, C., Razali, S. S. Yang, Sivasamy, V., Kuan, L. Y., Poulose, V., Morales, M. A. Lopez, Castro, S., Pires, T., Melão, L., Krystopchuk, A., Pereira, I., Granja, C., Taniguchi, L. U., Pires, E. M. C., Vieira, Jr, J. M., Azevedo, L. C. P., Nurses of the Central and General ICUs of Shiraz Namazi Hospital, Sedation an Delirium Group Hospital Universitari de Bellvitge, SPACeR group (Surrey Peri-operative, Anaesthesia and Critical Care Collaborative Research Group), for the PRoVENT investigators and the PROVE Network, SEMICYUC/GETGAG Working Group, TAVeM study group, POPC-CB investigators, DESIRE (DExmedetomidine for Sepsis in ICU Randomized Evaluation) Trial Investigators, GEMINI, Bioethics work group of SEMICYUC, The FINNAKI Study Group, Queen Square Neuroanaesthesia and Neurocritical Care Resreach Group, Renal Transplantation HUVR, GEMINI, EDISVAL Group, EDISVAL Group, PLUG Working group, TAVeM study Group, The FINNAKI Study Group, on behalf of Department of Professional Development, ESICM, Critical Care Research Group, SIRAKI group, and Grupo ESBAGA

Published
2016
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44. Impact of income status on prognosis of acute coronary syndrome patients during Greek financial crisis

Author

Andrikopoulos, George, Tzeis, Stylianos, Terentes-Printzios, Dimitrios, Varounis, Christos, Vlachopoulos, Charalampos, Mantas, Ioannis, Patsilinakos, Sotirios, Lampropoulos, Stylianos, Olympios, Christoforos, Kartalis, Athanasios, Manolis, Athanasios, Gotsis, Alexandros, Triposkiadis, Filippos, Tsaknakis, Themistoklis, Goudevenos, Ioannis, Kaprinis, Ioannis, Pras, Athanasios, Vasiliou, Fotios, Skoumpourdis, Emmanouil, Sakka, Gerasimoula, Draganigos, Antonios, and Vardas, Panos

Published
2016
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45. Expert consensus on the rational clinical use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors

Author

Achimastos, Apostolos, Alexandrides, Theodoras, Alexopoulos, Dimitrios, Athyros, Vasilios, Bargiota, Alexandra, Bilianou, Eleni, Chrysochoou, Christina, Drogari, Evridiki, Elisaf, Moses, Ganotakis, Emanouel, Goudevenos, Ioannis, Ioannidis, Ioannis, Kolovou, Genovefa, Kotsis, Vasilios, Lekakis, Ioannis, Liberopoulos, Evangelos, Melidonis, Andreas, Nikolaou, Vasilios, Ntaios, George, Papanas, Nikolaos, Pappas, Stavros, Pitsavos, Christos, Rallidis, Loukianos, Richter, Dimitrios, Skoumas, Ioannis, Tentolouris, Nicolaos, Tousoulis, Dimitrios, Tselepis, Alexandras, Tsioufis, Konstantinos, Tziakas, Dimitrios, Tziomalos, Konstantinos, Vardas, Panagiotis, Vlachopoulos, Charalabos, and Vlahakos, Dimitrios

Published
2016
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48. Safety of smartwatches and their chargers in patients with cardiac implantable electronic devices

Author

Konstantinos P. Letsas, Emmanuel P Vardas, Panagiotis Mililis, Konstantina S. Nikita, Dimitrios Asvestas, Stylianos Tzeis, Panos E. Vardas, Nektarios Moraitis, and Konstantinos G. Kouvelas

Subjects
Male, Pacemaker, Artificial, Continuous electrocardiogram, 030204 cardiovascular system & hematology, Electromagnetic interference, Implantable defibrillators, Smartwatch, 03 medical and health sciences, Electric Power Supplies, Electromagnetic Fields, 0302 clinical medicine, EMI, Physiology (medical), Humans, Medicine, In patient, 030212 general & internal medicine, Electronics, business.industry, Electrical engineering, Defibrillators, Implantable, Magnetic Fields, Female, Cardiology and Cardiovascular Medicine, business
Abstract

AimsCardiac implantable electronic devices (CIEDs) are susceptible to electromagnetic interference (EMI). Smartwatches and their chargers could be a possible source of EMI. We sought to assess whether the latest generation smartwatches and their chargers interfere with proper CIED function.Methods and resultsWe included consecutive CIED recipients in two centres. We tested two latest generation smartwatches (Apple Watch and Samsung Galaxy Watch) and their charging cables for potential EMI. The testing was performed under continuous electrocardiogram recording and real-time device telemetry, with nominal and ‘worst-case’ settings. In vitro magnetic field measurements were performed to assess the emissions from the tested devices, initially in contact with the probe and then at a distance of 10 cm and 20 cm. In total, 171 patients with CIEDs (71.3% pacemakers–28.7% implantable cardioverter-defibrillators) from five manufacturers were enrolled (63.2% males, 74.8 ± 11.4 years), resulting in 684 EMI tests. No EMI was identified in any patient either under nominal or ‘worst-case scenario’ programming. The peak magnetic flux density emitted by the smartwatches was similar to the background noise level (0.81 μT) even when in contact with the measuring probe. The respective values for the chargers were 4.696 μΤ and 4.299 μΤ for the Samsung and Apple chargers, respectively, which fell at the background noise level when placed at 20 cm and 10 cm, respectively.ConclusionTwo latest generation smartwatches and their chargers resulted in no EMI in CIED recipients. The absence of EMI in conjunction with the extremely low intensity of magnetic fields emitted by these devices support the safety of their use by CIED patients.

Published
2020
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49. The burden of atrial fibrillation and heart failure in hospitalized patients: A real-world survey in a nationwide snapshot

Author

Iliodromitis, Konstantinos, Tzeis, Stylianos, Xintarakou, Anastasia, Pyrgakis, Vlasios, Zarifis, Ioannis, Patsilinakos, Sotirios, Draganigos, Antonios, Triposkiadis, Filippos, Hahalis, George, Karanasios, Athanasios, Goudevenos, Ioannis, Michalis, Lampros, Karvounis, Charalampos, Parthenakis, Fraggiskos, Kanakakis, Ioannis, Tousoulis, Dimitrios, Iliodromitis, Efstathios, and Vardas, Panos

Abstract

Atrial fibrillation (AF) and heart failure (HF) are common and commonly coexisting cardiovascular diseases in hospitalized patients. We report the absolute number and interrelation between AF and HF, assess the daily burden of both diseases on the healthcare system, and describe the medical treatment in a real-world, nationwide conducted snapshot survey.

Published
2023
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50. The Role of Imaging in the Pre‐ and Postoperative Evaluation of Inguinal Hernia

Author

Vassalou, Evangelia E., Vardas, Konstantinos, Dimitriadis, Eustathios, and Perysinakis, Iraklis

Abstract

Inguinal hernia repair is the most frequently performed surgical procedure. Imaging has a fundamental role in initial assessment and postoperative evaluation of inguinal hernias. Clinical implications of radiology in the preoperative setting include diagnosis of occult/complicated hernias and enhancement of diagnostic certainty. Postoperatively, imaging may assist the detection and characterization of complications. Familiarity with the normal appearance of the postoperative groin area and surgical techniques is required to avoid misinterpretation. This pictorial essay provides an overview of the expected postoperative imaging findings and highlights the role of imaging in the pre‐ and postoperative evaluation of inguinal hernias, with emphasis on ultrasonography.

Published
2023
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