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1. Iron rescues glucose-mediated photosynthesis repression during lipid accumulation in the green alga Chromochloris zofingiensis

Author

Jeffers, Tim L, Purvine, Samuel O, Nicora, Carrie D, McCombs, Ryan, Upadhyaya, Shivani, Stroumza, Adrien, Whang, Ken, Gallaher, Sean D, Dohnalkova, Alice, Merchant, Sabeeha S, Lipton, Mary, Niyogi, Krishna K, and Roth, Melissa S

Subjects
Plant Biology, Biochemistry and Cell Biology, Biological Sciences, Industrial Biotechnology, 2.1 Biological and endogenous factors, Affordable and Clean Energy, Photosynthesis, Iron, Glucose, Triglycerides, Lipid Metabolism, Chlorophyta, Thylakoids, Proteomics, Hexokinase, Chlorophyceae
Abstract

Energy status and nutrients regulate photosynthetic protein expression. The unicellular green alga Chromochloris zofingiensis switches off photosynthesis in the presence of exogenous glucose (+Glc) in a process that depends on hexokinase (HXK1). Here, we show that this response requires that cells lack sufficient iron (-Fe). Cells grown in -Fe+Glc accumulate triacylglycerol (TAG) while losing photosynthesis and thylakoid membranes. However, cells with an iron supplement (+Fe+Glc) maintain photosynthesis and thylakoids while still accumulating TAG. Proteomic analysis shows that known photosynthetic proteins are most depleted in heterotrophy, alongside hundreds of uncharacterized, conserved proteins. Photosynthesis repression is associated with enzyme and transporter regulation that redirects iron resources to (a) respiratory instead of photosynthetic complexes and (b) a ferredoxin-dependent desaturase pathway supporting TAG accumulation rather than thylakoid lipid synthesis. Combining insights from diverse organisms from green algae to vascular plants, we show how iron and trophic constraints on metabolism aid gene discovery for photosynthesis and biofuel production.

Published
2024

2. Iron rescues glucose-mediated photosynthesis repression during lipid accumulation in the green alga Chromochloris zofingiensis

Author

Tim L. Jeffers, Samuel O. Purvine, Carrie D. Nicora, Ryan McCombs, Shivani Upadhyaya, Adrien Stroumza, Ken Whang, Sean D. Gallaher, Alice Dohnalkova, Sabeeha S. Merchant, Mary Lipton, Krishna K. Niyogi, and Melissa S. Roth

Subjects
Science
Abstract

Abstract Energy status and nutrients regulate photosynthetic protein expression. The unicellular green alga Chromochloris zofingiensis switches off photosynthesis in the presence of exogenous glucose (+Glc) in a process that depends on hexokinase (HXK1). Here, we show that this response requires that cells lack sufficient iron (−Fe). Cells grown in −Fe+Glc accumulate triacylglycerol (TAG) while losing photosynthesis and thylakoid membranes. However, cells with an iron supplement (+Fe+Glc) maintain photosynthesis and thylakoids while still accumulating TAG. Proteomic analysis shows that known photosynthetic proteins are most depleted in heterotrophy, alongside hundreds of uncharacterized, conserved proteins. Photosynthesis repression is associated with enzyme and transporter regulation that redirects iron resources to (a) respiratory instead of photosynthetic complexes and (b) a ferredoxin-dependent desaturase pathway supporting TAG accumulation rather than thylakoid lipid synthesis. Combining insights from diverse organisms from green algae to vascular plants, we show how iron and trophic constraints on metabolism aid gene discovery for photosynthesis and biofuel production.

Published
2024
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3. Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells.

Author

Nguyenla, Xammy, Wehri, Eddie, Van Dis, Erik, Biering, Scott B, Yamashiro, Livia H, Zhu, Chi, Stroumza, Julien, Dugast-Darzacq, Claire, Graham, Thomas GW, Wang, Xuanting, Jockusch, Steffen, Tao, Chuanjuan, Chien, Minchen, Xie, Wei, Patel, Dinshaw J, Meyer, Cindy, Garzia, Aitor, Tuschl, Thomas, Russo, James J, Ju, Jingyue, Näär, Anders M, Stanley, Sarah, and Schaletzky, Julia

Subjects
Lung, Humans, Hepacivirus, Hepatitis C, Nucleosides, Alanine, Adenosine Monophosphate, Antiviral Agents, Sofosbuvir, SARS-CoV-2, COVID-19 Drug Treatment, Infectious Diseases, Biodefense, Prevention, Chronic Liver Disease and Cirrhosis, Digestive Diseases, Pneumonia, Hepatitis - C, Emerging Infectious Diseases, Liver Disease, Pneumonia & Influenza, Vaccine Related, Lung Cancer, Hepatitis, Cancer, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Infection, Good Health and Well Being
Abstract

SARS coronavirus 2 (SARS-CoV-2) has caused an ongoing global pandemic with significant mortality and morbidity. At this time, the only FDA-approved therapeutic for COVID-19 is remdesivir, a broad-spectrum antiviral nucleoside analog. Efficacy is only moderate, and improved treatment strategies are urgently needed. To accomplish this goal, we devised a strategy to identify compounds that act synergistically with remdesivir in preventing SARS-CoV-2 replication. We conducted combinatorial high-throughput screening in the presence of submaximal remdesivir concentrations, using a human lung epithelial cell line infected with a clinical isolate of SARS-CoV-2. This identified 20 approved drugs that act synergistically with remdesivir, many with favorable pharmacokinetic and safety profiles. Strongest effects were observed with established antivirals, Hepatitis C virus nonstructural protein 5A (HCV NS5A) inhibitors velpatasvir and elbasvir. Combination with their partner drugs sofosbuvir and grazoprevir further increased efficacy, increasing remdesivir's apparent potency > 25-fold. We report that HCV NS5A inhibitors act on the SARS-CoV-2 exonuclease proofreader, providing a possible explanation for the synergy observed with nucleoside analog remdesivir. FDA-approved Hepatitis C therapeutics Epclusa® (velpatasvir/sofosbuvir) and Zepatier® (elbasvir/grazoprevir) could be further optimized to achieve potency and pharmacokinetic properties that support clinical evaluation in combination with remdesivir.

Published
2022

4. Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV‑2

Author

Biering, Scott B, Van Dis, Erik, Wehri, Eddie, Yamashiro, Livia H, Nguyenla, Xammy, Dugast-Darzacq, Claire, Graham, Thomas GW, Stroumza, Julien R, Golovkine, Guillaume R, Roberts, Allison W, Fines, Daniel M, Spradlin, Jessica N, Ward, Carl C, Bajaj, Teena, Dovala, Dustin, Schulze-Gamen, Ursula, Bajaj, Ruchika, Fox, Douglas M, Ott, Melanie, Murthy, Niren, Nomura, Daniel K, Schaletzky, Julia, and Stanley, Sarah A

Subjects
Vaccine Related, Pneumonia, Pneumonia & Influenza, Biodefense, Emerging Infectious Diseases, Rare Diseases, Infectious Diseases, Lung, Prevention, Orphan Drug, Biotechnology, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Infection, Good Health and Well Being, Antiviral Agents, COVID-19, Humans, Pandemics, SARS-CoV-2, antiviral, drug repurposing, synergy, B02, remdesivir, Medical Microbiology
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has emerged as a major global health threat. The COVID-19 pandemic has resulted in over 168 million cases and 3.4 million deaths to date, while the number of cases continues to rise. With limited therapeutic options, the identification of safe and effective therapeutics is urgently needed. The repurposing of known clinical compounds holds the potential for rapid identification of drugs effective against SARS-CoV-2. Here, we utilized a library of FDA-approved and well-studied preclinical and clinical compounds to screen for antivirals against SARS-CoV-2 in human pulmonary epithelial cells. We identified 13 compounds that exhibit potent antiviral activity across multiple orthogonal assays. Hits include known antivirals, compounds with anti-inflammatory activity, and compounds targeting host pathways such as kinases and proteases critical for SARS-CoV-2 replication. We identified seven compounds not previously reported to have activity against SARS-CoV-2, including B02, a human RAD51 inhibitor. We further demonstrated that B02 exhibits synergy with remdesivir, the only antiviral approved by the FDA to treat COVID-19, highlighting the potential for combination therapy. Taken together, our comparative compound screening strategy highlights the potential of drug repurposing screens to identify novel starting points for development of effective antiviral mono- or combination therapies to treat COVID-19.

Published
2021

5. Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells

Author

Xammy Nguyenla, Eddie Wehri, Erik Van Dis, Scott B. Biering, Livia H. Yamashiro, Chi Zhu, Julien Stroumza, Claire Dugast-Darzacq, Thomas G. W. Graham, Xuanting Wang, Steffen Jockusch, Chuanjuan Tao, Minchen Chien, Wei Xie, Dinshaw J. Patel, Cindy Meyer, Aitor Garzia, Thomas Tuschl, James J. Russo, Jingyue Ju, Anders M. Näär, Sarah Stanley, and Julia Schaletzky

Subjects
Medicine, Science
Abstract

Abstract SARS coronavirus 2 (SARS-CoV-2) has caused an ongoing global pandemic with significant mortality and morbidity. At this time, the only FDA-approved therapeutic for COVID-19 is remdesivir, a broad-spectrum antiviral nucleoside analog. Efficacy is only moderate, and improved treatment strategies are urgently needed. To accomplish this goal, we devised a strategy to identify compounds that act synergistically with remdesivir in preventing SARS-CoV-2 replication. We conducted combinatorial high-throughput screening in the presence of submaximal remdesivir concentrations, using a human lung epithelial cell line infected with a clinical isolate of SARS-CoV-2. This identified 20 approved drugs that act synergistically with remdesivir, many with favorable pharmacokinetic and safety profiles. Strongest effects were observed with established antivirals, Hepatitis C virus nonstructural protein 5A (HCV NS5A) inhibitors velpatasvir and elbasvir. Combination with their partner drugs sofosbuvir and grazoprevir further increased efficacy, increasing remdesivir’s apparent potency > 25-fold. We report that HCV NS5A inhibitors act on the SARS-CoV-2 exonuclease proofreader, providing a possible explanation for the synergy observed with nucleoside analog remdesivir. FDA-approved Hepatitis C therapeutics Epclusa® (velpatasvir/sofosbuvir) and Zepatier® (elbasvir/grazoprevir) could be further optimized to achieve potency and pharmacokinetic properties that support clinical evaluation in combination with remdesivir.

Published
2022
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6. Des réussites bien particulières dans un dispositif de coprésence du champ de la protection de l’enfance : entre énigmes et paris

Author

Kim Stroumza, Marc Pittet, Anne-Françoise Pont, Laetitia Krummenacher, and Flavio Fersini

Subjects
family and education, childhood and youth, Switzerland, education policies, organization and functioning of the establishments, Education
Abstract

This article focuses on moments of copresence between a parent, a child, and a professional in the course of ordinary activities (chatting, eating, playing, etc.) within a placement apparatus in the field of child protection in Switzerland. Adopting a work analysis approach, we seek to describe not only how this apparatus prompts professionals, parents, and children to act and how it acts upon them, but also how the professionals inhabit it. We look at how they engage with and disengage from the power relations inherent to a compulsory-assistance apparatus as they carry out their activities ; how, they are able to encourage effects (reciprocal implication, participation in and appropriation of the apparatus) that they may not be deliberately pursuing but that at times constitute a rather singular form of success.

Published
2022
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7. Periodontitis and early mortality among adults treated with hemodialysis: a multinational propensity-matched cohort study

Author

Marinella Ruospo, Suetonia C Palmer, Germaine Wong, Jonathan C Craig, Massimo Petruzzi, Michele De Benedittis, Pauline Ford, David W Johnson, Marcello Tonelli, Patrizia Natale, Valeria Saglimbene, Fabio Pellegrini, Eduardo Celia, Ruben Gelfman, Miguel R Leal, Marietta Torok, Paul Stroumza, Anna Bednarek-Skublewska, Jan Dulawa, Luc Frantzen, Domingo del Castillo, Staffan Schon, Amparo G Bernat, Jorgen Hegbrant, Charlotta Wollheim, Letizia Gargano, Casper P. Bots, Giovanni FM Strippoli, and on behalf of the ORALD Investigators

Subjects
End-stage kidney disease, Hemodialysis, Oral health, Periodontal disease, All-cause mortality, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background Periodontitis is associated with cardiovascular mortality in the general population and adults with chronic diseases. However, it is unclear whether periodontitis predicts survival in the setting of kidney failure. Methods ORAL-D was a propensity matched analysis in 3338 dentate adults with end-stage kidney disease treated in a hemodialysis network in Europe and South America designed to examine the association between periodontitis and all-cause and cardiovascular-related mortality in people on long-term hemodialysis. Participants were matched 1:1 on their propensity score for moderate to severe periodontitis assessed using the World Health Organization Community Periodontal Index. A random-effects Cox proportional hazards model was fitted with shared frailty to account for clustering of mortality risk within countries. Results Among the 3338 dentate participants, 1355 (40.6%) had moderate to severe periodontitis at baseline. After using propensity score methods to generate a matched cohort of participants with periodontitis similar to those with none or mild periodontal disease, moderate to severe periodontitis was associated with a lower risk of all-cause (9.1 versus 13.0 per 100 person years, hazard ratio 0.74, 95% confidence interval 0.61 to 0.90) and cardiovascular (4.3 versus 6.9 per 100 person years, hazard ratio 0.67, 0.51 to 0.88) mortality. These associations were not changed substantially when participants were limited to those with 12 or more natural teeth and when accounting for competing causes of cardiovascular death. Conclusion In contrast to the general population, periodontitis does not appear to be associated with an increased risk of early death in adults treated with hemodialysis.

Published
2017
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8. Oral mucosal lesions and risk of all-cause and cardiovascular mortality in people treated with long-term haemodialysis: The ORAL-D multinational cohort study.

Author

Marinella Ruospo, Suetonia C Palmer, Giusi Graziano, Patrizia Natale, Valeria Saglimbene, Massimo Petruzzi, Michele De Benedittis, Jonathan C Craig, David W Johnson, Pauline Ford, Marcello Tonelli, Eduardo Celia, Ruben Gelfman, Miguel R Leal, Marietta Török, Paul Stroumza, Luc Frantzen, Anna Bednarek-Skublewska, Jan Dulawa, Domingo Del Castillo, Staffan Schön, Amparo G Bernat, Jörgen Hegbrant, Charlotta Wollheim, Letizia Gargano, Giovanni F M Strippoli, and ORAL-D Investigators

Subjects
Medicine, Science
Abstract

BackgroundChronic kidney disease is a risk factor for oral diseases, which may be associated with premature death. We evaluated the risk of all-cause and cardiovascular mortality associated with oral mucosal lesions in adults with kidney failure treated with long-term haemodialysis.MethodsOral mucosal lesions (herpes, ulceration, neoformation, white lesion, red lesion, oral candidiasis, geographical tongue, petechial lesions, and fissured tongue) were evaluated within the Oral Diseases in Haemodialysis (ORAL-D) study, a multinational cohort study of 4726 haemodialysis adults. We conducted cox regression analyses adjusted for demographic and clinical variables to evaluate the association with all-cause and cardiovascular mortality.ResultsOverall, 4205 adults (mean age 61.6 ± 15.6 years) underwent oral mucosal examination with 40% affected by at least one lesion. The prevalence of oral lesions was (in order of frequency): oral herpes 0.5%, mucosal ulceration 1.7%, neoformation 2.0%, white lesion 3.5%, red lesion 4.0%, oral candidiasis 4.6%, geographical tongue 4.9%, petechial lesions 7.9%, and fissured tongue 10.7%. During median follow-up of 3.5 years, 2114 patients died (1013 due to cardiovascular disease). No association was observed between any individual oral lesion and all-cause or cardiovascular mortality when adjusted for comorbidities, except for oral candidiasis, which was associated with all-cause mortality (adjusted hazard ratio 1.37, 95% CI 1.00 to 1.86) and cardiovascular mortality (adjusted hazard ratio 1.64, 95% CI 1.09 to 2.46).ConclusionOral mucosal lesions are prevalent in haemodialysis patients. Oral candidiasis appears to be a risk factor for death due to cardiovascular diseases.

Published
2019
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9. The prevalence and correlates of low sexual functioning in women on hemodialysis: A multinational, cross-sectional study.

Author

Valeria Saglimbene, Patrizia Natale, Suetonia Palmer, Marco Scardapane, Jonathan C Craig, Marinella Ruospo, Letizia Gargano, Giuseppe Lucisano, Marietta Török, Eduardo Celia, Rubén Gelfman, Anna Bednarek-Skublewska, Jan Dulawa, Paul Stroumza, Miguel Leal, Domingo Del Castillo, Angelo Marco Murgo, Staffan Schon, Charlotta Wollheim, Jörgen Hegbrant, and Giovanni F M Strippoli

Subjects
Medicine, Science
Abstract

Sexual dysfunction may affect 80% of women in hemodialysis. However the specific patterns and clinical correlates of sexual functioning remain poorly described. The aim of this study was to assess prevalence and correlates of the individual domains of sexual functioning in women treated with hemodialysis. We recruited, into this multinational cross-sectional study, women treated with long-term hemodialysis (Collaborative Working Group on Depression and Sexual dysfunction in Hemodialysis study). Self-reported domains of sexual functioning were assessed by the Female Sexual Function Index, which is routinely administered within the network of dialysis patients followed by the working group. Lower scores represented lower sexual functioning. Socio-demographic and clinical correlates of each domain of sexual functioning were identified by stepwise multivariable linear regression. Sensitivity analyses were restricted to women who reported being sexually active. We found that of 1309 enrolled women, 659 (50.3%) provided complete responses to FSFI survey questions and 232 (35%) reported being sexually active. Overall, most respondents reported either no sexual activity or low sexual functioning in all measured domains (orgasm 75.1%; arousal 64.0%; lubrication 63.3%; pain 60.7%; satisfaction 60.1%; sexual desire 58.0%). Respondents who were waitlisted for a kidney transplant reported scores with higher sexual functioning, while older respondents reported scores with lower functioning. The presence of depression was associated with worse lubrication and pain scores [mean difference for depressed versus non-depressed women (95% CI) -0.42 (-0.73 to -0.11), -0.53 (-0.89 to -0.16), respectively] while women who had experienced a previous cardiovascular event reported higher pain scores [-0.77 (-1.40- to -0.13)]. In conclusion, women in hemodialysis reported scores consistent with marked low sexual functioning across a range of domains; the low functioning appeared to be associated with comorbidity.

Published
2017
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10. Un dilemme pratique à trancher depuis des valeurs logées dans l’activité

Author

Sylvie Mezzena, Kim Stroumza, and Nicolas Kramer

Subjects
values, knowledge, colloquium, dilemma, professionality of special educators, Psychology, BF1-990, Social Sciences
Abstract

In our research on the construction of professionality derived from professional activity, we examine the development of values based on practical inquiries of special educators working in a home for adolescents whose family and social situations have broken down. In the context of a dual mission, based on creating integration workshops, we analyze in practical terms how the professionals retain certain of their values by confronting the dilemmas they face during the fulfillment of their mission. We examine the role and place of values as situated conducts that we conceive to be guides for stabilizing ways of constructing practical problems. An analysis of discussions at symposia provides the opportunity to observe the extent to which professionals’ assessments, which consist in assigning value to the relationships with other objects in the work place, are continuous and critical to the activity. They allow a continuous search for effects as a perspective from which to orientate their practical inquiries. This finding provides a means to problematize values in a manner which is not absolutist and which does not bring them into conflict with professional expertise or technicality. In our situated approach, which focuses on a developing set of skills, values and knowledge are combined in the inquiry process that builds professionality. This leads us to consider, in particular, the classic definition of representational knowledge. Finally, we draw conclusions regarding the definition of professionality.

Published
2016
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11. De la réflexivité du sujet aux enquêtes pratiques dans l’activité d’éducateurs spécialisés

Author

Sylvie Mezzena, Kim Stroumza, Laurence Seferdjeli, and Pascal Baumgartner

Subjects
activity, practical inquiry, dynamic combinations, perspective, externalization of thought, Psychology, BF1-990, Social Sciences
Abstract

Drawing on Ogien and Quere’s situated approach to French sociology of action, linked to Dewey’s pragmatist philosophy, our analysis of the activities of special educators combined with a broader literature on work analysis suggests that the reflexivity of professionals is insufficient to account for the construction and effectiveness of the intervention process. As defined by Schon’s reflexive practitioner model and its offshoots, it is a work of distancing, analyzing and formalizing their practice and as such feeds a negative and restricted conception of professionalism. Our research was conducted by a team in a shelter for adolescents from dysfunctional families, required by policy to develop a new mission of integration. Despite team meetings targeting the development of new rules, weekly seminars aimed at solving recent practical problems, informal exchanges between colleagues during the course of their work, pre-or post-activity interviews and self-analysis undertaken with professionals for research purposes, the activity continually escapes formalization. Drawing on an alternative model of professionalism based on a Deweyan notion of survey, our analysis of surveys of professional practice, both longitudinal and cross-sectional, shows that intervention requires know-how built in to the activity, even where so-called "basic" practices are concerned. It continually requires exploratory adjustments driven by the elements of the action. This suggests that the implementation of the mission does not depend on applicationist logic. This approach leads to a form of externalization of thought during the activity, defining practice as the place where knowledge is constructed without subordinating it to reflexivity as an intellectual process added to practice.

Published
2013
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12. Partenariat de recherche en Hautes écoles spécialisées Santé Travail social de Suisse occidentale

Author

Laurence Seferdjeli and Kim Stroumza

Subjects
learning, commitment, University of Applied Sciences of Switzerland, partnership, spokeperson, applied research, Sociology (General), HM401-1281
Abstract

At the heart of the new research policies tending towards innovation, the Swiss Universities of applied sciences, recently promoted to tertiary academic rank, have been given, as primary mission, to extend their activities in Applied Research and Development. If scientific valorization of this kind of research is visible in current media and publications, it is not so apparent for the partnership itself or the processes which constituted its development in the first place. The analysis of the narrations of the protagonists of the partnership shows the phenomenon which illustrates the specificity of this activity, that valorization models are unable to grasp. Caught between regular practice, professional and scientific activities, subject also to the temporality of the process, partnership activities question the very concept of the knowledge which underlines the models of applied research.

Published
2011

13. Epidemiology and outcome research in CKD 5D

Author

L. Coentrao, C. Ribeiro, C. Santos-Araujo, R. Neto, M. Pestana, W. Kleophas, A. Karaboyas, Y. LI, J. Bommer, R. Pisoni, B. Robinson, F. Port, G. Celik, B. Burcak Annagur, M. Yilmaz, T. Demir, F. Kara, K. Trigka, P. Dousdampanis, N. Vaitsis, S. Aggelakou-Vaitsi, K. Turkmen, I. Guney, F. Turgut, L. Altintepe, H. Z. Tonbul, E. Abdel-Rahman, P. Sclauzero, G. Galli, G. Barbati, M. Carraro, G. O. Panzetta, M. Van Diepen, M. Schroijen, O. Dekkers, F. Dekker, A. Sikole, G. Severova- Andreevska, L. Trajceska, S. Gelev, V. Amitov, S. Pavleska- Kuzmanovska, H. Rayner, R. Vanholder, M. Hecking, B. Jung, M. Leung, F. Huynh, T. Chung, S. Marchuk, M. Kiaii, L. Er, R. Werb, C. Chan-Yan, M. Beaulieu, P. Malindretos, P. Makri, G. Zagkotsis, G. Koutroumbas, G. Loukas, E. Nikolaou, M. Pavlou, E. Gourgoulianni, M. Paparizou, M. Markou, E. Syrgani, C. Syrganis, J. Raimann, L. A. Usvyat, V. Bhalani, N. W. Levin, P. Kotanko, X. Huang, P. Stenvinkel, A. R. Qureshi, U. Riserus, T. Cederholm, P. Barany, O. Heimburger, B. Lindholm, J. J. Carrero, J. H. Chang, J. Y. Sung, J. Y. Jung, H. H. Lee, W. Chung, S. Kim, J. S. Han, K. Y. Na, A. Fragoso, A. Pinho, A. Malho, A. P. Silva, E. Morgado, P. Leao Neves, N. Joki, Y. Tanaka, M. Iwasaki, S. Kubo, T. Hayashi, Y. Takahashi, K. Hirahata, Y. Imamura, H. Hase, C. Castledine, J. Gilg, C. Rogers, Y. Ben-Shlomo, F. Caskey, J. S. Sandhu, G. S. Bajwa, S. Kansal, J. Sandhu, A. Jayanti, M. Nikam, L. Ebah, A. Summers, S. Mitra, J. Agar, A. Perkins, R. Simmonds, A. Tjipto, S. Amet, V. Launay-Vacher, M. Laville, A. Tricotel, C. Frances, B. Stengel, J.-Y. Gauvrit, N. Grenier, G. Reinhardt, O. Clement, N. Janus, L. Rouillon, G. Choukroun, G. Deray, A. Bernasconi, R. Waisman, A. P. Montoya, A. A. Liste, R. Hermes, G. Muguerza, R. Heguilen, E. L. Iliescu, V. Martina, M. A. Rizzo, P. Magenta, L. Lubatti, G. Rombola, M. Gallieni, C. Loirat, H. Mellerio, M. Labeguerie, B. Andriss, E. Savoye, M. Lassale, C. Jacquelinet, C. Alberti, Y. Aggarwal, J. Baharani, S. Tabrizian, S. Ossareh, M. Zebarjadi, P. Azevedo, F. Travassos, I. Frade, M. Almeida, J. Queiros, F. Silva, A. Cabrita, R. Rodrigues, C. Couchoud, J. Kitty, S. Benedicte, C. Fergus, C. Cecile, B. Sahar, V. Emmanuel, J. Christian, E. Rene, H. Barahimi, M. Mahdavi-Mazdeh, M. Nafar, M. Petruzzi, M. De Benedittis, M. Sciancalepore, L. Gargano, P. Natale, M. C. Vecchio, V. Saglimbene, F. Pellegrini, G. Gentile, P. Stroumza, L. Frantzen, M. Leal, M. Torok, A. Bednarek, J. Dulawa, E. Celia, R. Gelfman, J. Hegbrant, C. Wollheim, S. Palmer, D. W. Johnson, P. J. Ford, J. C. Craig, G. F. Strippoli, M. Ruospo, B. El Hayek, B. Hayek, E. Baamonde, E. Bosch, J. I. Ramirez, G. Perez, A. Ramirez, A. Toledo, M. M. Lago, C. Garcia-Canton, M. D. Checa, B. Canaud, B. Lantz, A. Granger-Vallee, P. Lertdumrongluk, N. Molinari, J. Ethier, M. Jadoul, B. Gillespie, C. Bond, S. Wang, T. Alfieri, P. Braunhofer, B. Newsome, M. Wang, B. Bieber, M. Guidinger, L. Zuo, X. Yu, X. Yang, J. Qian, N. Chen, J. Albert, Y. Yan, S. Ramirez, M. Beresan, A. Lapidus, M. Canteli, A. Tong, B. Manns, J. Craig, G. Strippoli, M. Mortazavi, B. Vahdatpour, S. Shahidi, A. Ghasempour, D. Taheri, S. Dolatkhah, A. Emami Naieni, M. Ghassami, M. Khan, K. Abdulnabi, P. Pai, M. Vecchio, M. A. Muqueet, M. J. Hasan, M. A. Kashem, P. K. Dutta, F. X. Liu, L. Noe, T. Quock, N. Neil, G. Inglese, M. Motamed Najjar, B. Bahmani, A. Shafiabadi, J. Helve, M. Haapio, P.-H. Groop, C. Gronhagen-Riska, P. Finne, R. Sund, M. Cai, S. Baweja, A. Clements, A. Kent, R. Reilly, N. Taylor, S. Holt, L. Mcmahon, M. Carter, F. M. Van der Sande, J. Kooman, R. Malhotra, G. Ouellet, E. L. Penne, S. Thijssen, M. Etter, A. Tashman, A. Guinsburg, A. Grassmann, C. Barth, C. Marelli, D. Marcelli, G. Von Gersdorff, I. Bayh, L. Scatizzi, M. Lam, M. Schaller, T. Toffelmire, Y. Wang, P. Sheppard, L. Neri, V. A. Andreucci, L. A. Rocca-Rey, S. V. Bertoli, D. Brancaccio, G. De Berardis, G. Lucisano, D. Johnson, A. Nicolucci, C. Bonifati, S. D. Navaneethan, V. Montinaro, M. Zsom, A. Bednarek-Skublewska, G. Graziano, J. N. Ferrari, A. Santoro, A. Zucchelli, G. Triolo, S. Maffei, S. De Cosmo, V. M. Manfreda, L. Juillard, A. Rousset, F. Butel, S. Girardot-Seguin, T. Hannedouche, M. Isnard, Y. Berland, P. Vanhille, J.-P. Ortiz, G. Janin, P. Nicoud, M. Touam, E. Bruce, B. Grace, P. Clayton, A. Cass, S. Mcdonald, Y. Furumatsu, T. Kitamura, N. Fujii, S. Ogata, H. Nakamoto, K. Iseki, Y. Tsubakihara, C.-C. Chien, J.-J. Wang, J.-C. Hwang, H.-Y. Wang, W.-C. Kan, N. Kuster, L. Patrier, A.-S. Bargnoux, M. Morena, A.-M. Dupuy, S. Badiou, J.-P. Cristol, J.-M. Desmet, V. Fernandes, F. Collart, N. Spinogatti, J.-M. Pochet, M. Dratwa, E. Goffin, J. Nortier, D. S. Zilisteanu, M. Voiculescu, E. Rusu, C. Achim, R. Bobeica, S. Balanica, T. Atasie, S. Florence, S. Anne-Marie, L. Michel, C. Cyrille, A. Strakosha, N. Pasko, S. Kodra, N. Thereska, A. Lowney, E. Lowney, R. Grant, M. Murphy, L. Casserly, T. O' Brien, W. D. Plant, J. Radic, D. Ljutic, V. Kovacic, M. Radic, K. Dodig-Curkovic, M. Sain, I. Jelicic, T. Hamano, C. Nakano, S. Yonemoto, A. Okuno, M. Katayama, Y. Isaka, M. Nordio, A. Limido, M. Postorino, M. Nichelatti, M. Khil, I. Dudar, V. Khil, I. Shifris, M. Momtaz, A. R. Soliman, M. I. El Lawindi, P. Dzekova-Vidimliski, S. Pavleska-Kuzmanovska, I. Nikolov, G. Selim, T. Shoji, R. Kakiya, N. Tatsumi-Shimomura, Y. Tsujimoto, T. Tabata, H. Shima, K. Mori, S. Fukumoto, H. Tahara, H. Koyama, M. Emoto, E. Ishimura, Y. Nishizawa, and M. Inaba

Subjects
Transplantation, medicine.medical_specialty, Nephrology, business.industry, Epidemiology, Medicine, business, Intensive care medicine, Outcome (game theory)
Published
2012

14. Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients

Author

Couchoud, Cécile, Bayer, Florian, Ayav, Carole, Béchade, Clémence, Brunet, Philippe, Chantrel, François, Frimat, Luc, Galland, Roula, Hourmant, Maryvonne, Laurain, Emmanuelle, Lobbedez, Thierry, Mercadal, Lucile, Moranne, Olivier, Abbassi, Abdelhamid, Debure, Alain, Guerraoui, Abdallah, Benmoussa, Abdelatif, Hamani, Abdelaziz, Ziane, Abdelaziz, Nefti, Abdelhamid, Hadj, Abdelkader, El Amari, Abderrahim, Ghazali, Abderrahmane, Abd El Fatah Mohamed, Abo Bakr, Laradi, Achour, Ben Ahmed, Adel, Sahar, Adel, Pillet, Adele, Lacraz, Adeline, Moinat, Adnan, Massoumi, Afshin, Pardon, Agathe, Beaudoin, Agnes Caillette, Debout, Agnes Chapelet, Mariot, Agnes, Rachi, Ahmed, Afiani, Aida, Boula, Aime Remy, Jalaby, Al, Cremault, Alain, Fournier, Alain, Jeanson, Alain, Lyon, Alain, Nony, Alain, Robert, Alain, Slingeneyer, Alain, Labatide, Alanor Agnes, Sartorius, Albane Brodin, Bensman, Albert, Fournier, Albert, Ranlin, Alex, Sandor, Alex Vido, Colombo, Alexandra, Duhem, Alexandra, Stancu, Alexandra, Dufay, Alexandre, Dumoulin, Alexandre, Ebel, Alexandre, Klein, Alexandre, Martin, Alexandre, Mouneimne, Alexandre, Seidowsky, Alexandre, De Martin, Alfio, Zannier, Alfredo, Aizel, Ali, Hafi, Ali, Diddaoui, Ali Zineddine, Heyani, Alim, Mocanu, Alina, Preda, Alina, Hafi, Aline, Talaszka, Aline, Duquesne, Alyette, Amaouche, Amar, Ghemmour, Amel, Simon, Amelie, Skalli, Amina, Boukadida, Amine, Ragab Eid, Amr Ekhlas, Fedorca, Ana, Baillet, Anabelle, Poyet, Anais, Giorgita, Ancuta Bouffandeau, Ratsimbazafy, Anderson, Pruna, Andre, Argiles, Angel, Testa, Angelo, Vandooren, Ann Karolien, Jolivot, Anne, Labadens, Anne Kolko, Lataste, Anne, Maisin, Anne, Paris, Anne, Sechet, Anne, Wuillai, Anne, Heng, Anne Elisabeth, Josse, Anne Gaelle, Querard, Anne Helene, Reboux, Anne Helene, Adra, Anne Laure, Faller, Anne Laure, Leclerc, Anne Laure, Poitou, Anne Laure, Manucci, Annie Lahoche, Jacquet, Antoine, Pommereau, Antoine, Thierry, Antoine, Adem, Arezki, Chapelet, Arielle, Del Bello, Arnaud, Delezire, Arnaud, Garnier, Arnaud, Guerard, Arnaud, Klisnick, Arnaud, Lionet, Arnaud, Roccabianca, Arnaud, Stolz, Arnaud, Capdeville, Arthur, Allal, Asma, Alrifai, Assem, Diarrassouba, Assetou, Djema, Assia, Carre, Assia Ferhat, Dubrasquet, Astrid Godron, Elmrabet, Atman Haddj, Jegado, Audrey, Thomas, Aurelia Bertholet, Salandre, Aurelie Davourie, Pajot, Aurelie, Lorthioir, Aurelien, Tiple, Aurelien, Sury, Aurore, Abokasem, Ayman, Sarraj, Ayman, Henaoui, Bachir, Chaghouri, Baher, Wehbe, Bassem, Ball, Beatrice, Viron, Beatrice, Issad, Belkassem, Corne, Benedicte Hodemon, Janbon, Benedicte, Deroure, Benjamin, Savenkoff, Benjamin, Jonon, Benoit, Vendrely, Benoit, Djelaleddine, Benyakoub, Ohry, Bernard, Painchart, Bernard, Strullu, Bernard, Temperville, Bernard, Ebikili, Bertin, Hacq, Bertrand, Morel, Bertrand, Aoun, Bilal, Muniz, Blanca, Chlih, Bouchra, Amara, Brahim, Mayor, Brice, Gilson, Brigitte, Llanas, Brigitte, Zins, Brigitte, Bourgeon, Bruno, Coevoet, Bruno, Guery, Bruno, Legallicier, Bruno, Paris, Bruno, Ranchin, Bruno, Seigneuric, Bruno, Dita, Camelia Ghiciuc, Prelipcean, Camelia, Hottelart, Carine Achard, Diet, Carine, Frangie, Carlos, Vela, Carlos, Muresan, Carmina, Deprele, Carole, Araujo, Caroline, Bidault, Caroline, Creput, Caroline, Delclaux, Caroline, Du Halgouet, Caroline, Favennec, Caroline, Freguin, Caroline, Vercel, Caroline Gourraud, Mesguen, Caroline, Obama, Caroline Ndomo, Poitou, Caroline, Dirhold, Caroline Preissig, Roubiou, Caroline, Albert, Catherine, Bessin, Catherine, De Marion Gaja, Catherine, Godart, Catherine, Lasseur, Catherine, Leocardi, Catherine, Lumbroso, Catherine, Melander, Catherine, Michel, Catherine, Maurouard, Catherine Quere, Rouannet, Catherine, Taddei, Catherine, Verove, Cathy, Guiraud, Cecile, Tafelin, Cecile, Baron, Cecile Turc, Formet, Cedric, Pinier, Cedric, De Ste Foy, Celia Lessore, Granolleras, Celine, Bennini, Chaouki, Cartou, Charles, Chazot, Charles, Jouzel, Charlotte, Badid, Cherif, Roubicek, Christa, Viaud, Christel, Verrier, Christelle, Chuet, Christian, Combe, Christian, Dabot, Christian, Duvic, Christian, Emond, Christian, Lagarde, Christian, Lamotte, Christian, Pain, Christian, Mousson, Christiane, Lorriaux, Christie, Beauchamp, Christine, Fumeron, Christine, Le Gurun, Christine, Leroy, Christine, Pietrement, Christine, Richer, Christine, Bouaka, Christophe, Charasse, Christophe, Goupy, Christophe, Ridel, Christophe, Castrale, Cindy, Detourne, Cindy, Francois, Clair, Presne, Claire, Trivin, Claire, Von Kotze, Clarissa, Bernard, Claude, Bonniol, Claude, Desvergnes, Claude, Raharivelina, Claude, Nistor, Claudia, Gueret, Claudine, Lloret, Claudine, Saltiel, Claudine, Rosati, Clelia, Rabate, Clementine, Stanescu, Corina, Ferrandini, Corinne, Guibergia, Corinne, Lemoine, Corinne, Passeron, Corinne, Kahil, Cynthia, Garrouste, Cyril, Van, Cyril Vo, Jolimoy, Cyrille, Kesraoui, Dalila, Jolly, Damien, Thibaudin, Damien, Teboulle, Dan, Daubresse, Daniel, Louvet, Daniel, Rasamimanantsoa, Daniel, Toledano, Daniel, Babici, Daniela, David, Daniela, Dincu, Daniela, Bruno, Danielle, May, Delia, Haussaire, Delphine, Viprey, Delphine Henriet, Bugnon, Denis, Fouque, Denis, Morin, Denis, Nour, Derradji, Mahmoud, Diab Mohamed, Cristescu, Diana Istrati, Aguilera, Didier, Coste, Didier, Hamel, Didier, Le Chapois, Didier, Testou, Didier, Erbilgin, Dilaver, Dahmane, Djamal, Quang, Doan Bui, Bertrand, Dominique, Besnier, Dominique, Blanchier, Dominique, Briffa, Dominique, Caux, Dominique, Durand, Dominique, Fleury, Dominique, Guerrot, Dominique, Hestin, Dominique, Jaubert, Dominique, Joly, Dominique, Lombart, Dominique, Pagniez, Dominique, Pierre, Dominique, Schohn, Dominique, Ikonga, Donatien, Visanica, Dorina, Bazin, Dorothee, Boury, Edouard, Maksour, Edouard, Agbonon, Ekoue, Harrami, Elarbi, Marcu, Elena, Tudorache, Elena, Caniot, Elisabeth, Semjen, Elisabeth, Tomkiewicz, Elisabeth, Scheidt, Elise, Gaboriau, Elke, Lamouroux, Elodie, Guiard, Elsa, Passos, Elsa Martin, Nsembani, Emerson, Fache, Emilie, Kalbacher, Emilie, Pambrun, Emilie, Pincon, Emilie, Launay, Emma Allain, Baron, Emmanuel, Dupuis, Emmanuel, Villar, Emmanuel, Charlin, Emmanuelle, Hecquet, Emmanuelle, Kohler, Emmanuelle, Laurain, Emmanuelle, Rosier, Emmanuelle, Figueroa, Enrique, Azoulay, Eric, Canivet, Eric, Daugas, Eric, Gauthier, Eric, Laruelle, Eric, Le Guen, Eric, Legrand, Eric, Moumas, Eric, Postec, Eric, Prinz, Eric, Renaudineau, Eric, Desport, Estelle, Sutra, Estelle Ricard, Berard, Etienne, Ged, Etienne, Robin, Etienne, Vilaine, Eve, Bargas, Evelyne, Namara, Evelyne Mac, Combarnous, François, Yazbeck, Fatima, Gerard, Fabien, Metivier, Fabien, Parazols, Fabien, Soulis, Fabien, Garnier, Fabrice, Messaoudene, Fadhila Pech, Haidar, Fadi, Boullenger, Fanny, Lepeytre, Fanny, Leroy, Fanny, Frejate, Fares, Bellahsene, Farid, Bellhasene, Farid, Saidani, Farid, Toure, Fatouma, Kriaa, Faycal, Nemmar, Fazia, Vetromile, Fernando, Chalmin, Florence, Lucats, Florence, Sens, Florence, Villemain, Florence, Plasse, Florent, Lebhour, Fouad, Schillinger, Francis, Berge, Franck, Bourdon, Franck, Bridoux, Franck, Reynaud, Franck, Babinet, Francois, Basse, Francois, Chantrel, Francois, Clair, Francois, Coulomb, Francois, De Cornelissen, Francois, Glowacki, Francois, Marchal, Francois, Maurice, Francois, Nobili, Francois, Pourreau, Francois, Provot, Francois, Amani, Francois Roux, Broux, Francoise, Bulte, Francoise, Heibel, Francoise, Leonetti, Francoise, Schott, Francoise Moussion, Le Roy, Frank, Besson, Frederic, Lavainne, Frederic, Tollis, Frederic, Bocquentin, Frederique, Meeus, Frederique, Vecina, Frederique, Von Ey, Friederike, Balit, Gabriel, Choukroun, Gabriel, Gruget, Gabriel, Huchard, Gabriel, Golea, Gabriella, Duneau, Gabrielle, Lefrancois, Gaelle, Pelle, Gaelle, Lebrun, Gaetan, Dumont, Genevieve, Brillet, Georges, Deschenes, Georges, Mourad, Georges, Stamatakis, Georges, Cazajous, Geraldine, D'ythurbide, Geraldine, Wiart, Geraldine Robitaille, Cardon, Gerard, Champion, Gerard, Deschodt, Gerard, Mangenot, Gerard, Motte, Gerard, Schortgen, Gerard, Boulahia, Ghada, Maakaroun, Ghassan, Michel, Ghylene Bourdat, Zanetta, Gilbert, Hufnagel, Gilles, Messier, Gilles, Piccoli, Giorgina, Desvergnes, Gregoire Couvrat, Bobrie, Guillaume, Bonnard, Guillaume, Clement, Guillaume, Jean, Guillaume, Queffeulou, Guillaume, Seret, Guillaume, Vernin, Guillaume, Delavaud, Guy, Lambrey, Guy, Rostoker, Guy, Poussard, Gwenaelle, Kesler, Gwenaelle Roussey, Leon, H., Aboubekr, Habib, Boulechfar, Hacene, Sekhri, Hacene, Hebibi, Hadia, Benalia, Hadjira, Fessi, Hafed, Atchia, Hafsabhai, Bittar, Haiat, Maiza, Hakim, Mazouz, Hakim, El Ali, Hamid, Bougrida, Hammouche, Van Der Pijl, Hans, Lokmane, Hassan, Izzedine, Hassane, Adda, Hassen, De Preneuf, Helene, Leray, Helene, Philippot, Helene, Boulanger, Henri, Merault, Henri, Renaud, Henri, Bonarek, Herve, Maheut, Herve, Nzeyimana, Hilaire, Mehama, Hocine, Zaidi, Hocine, Weclawiak, Hugo, Flodrops, Hugues, Karaaslan, Huseyin, Haskour, Ibrahim, Belhadj, Ihssen, Almoubarak, Imad, Haddad, Imad, Castellano, Ines, Ferrandiz, Ines, Daniliuc, Ioana, Darie, Ioana, Enache, Ioana, Prunescu, Ionut, Djiconkpode, Irenee, Shahapuni, Irina, Bouchoule, Isabelle, Devriendt, Isabelle, Kazes, Isabelle, Kolb, Isabelle, Landru, Isabelle, Poli, Isabelle, Rey, Isabelle, Segalen, Isabelle, Selcer, Isabelle, Vernier, Isabelle, Vrillon, Isabelle, Guenifi, Ismahane, Gheerbrandt, J. Dominique, Potier, Jacky, Becart, Jacques, Cledes, Jacques, Ducros, Jacques, Duvic, Jacques, Fourcade, Jacques, Gaultier, Jacques, Jurine, Jacques, Lebleu, Jacques, Ollier, Jacques, Charles, Jacques Ibsen, Yazji, Jamal, Mansour, Janette, Arnautou, Jean, Brocard, Jean, Carolfi, Jean, Montoriol, Jean, Gouin, Jean Baptiste, Palcoux, Jean Bernard, Bendini, Jean Christophe, Aldigier, Jean Claude, Alphonse, Jean Claude, Delbet, Jean Daniel, Bonne, Jean Francois, Cantin, Jean Francois, De Fremont, Jean Francois, Dessassis, Jean Francois, Subra, Jean Francois, Valentin, Jean Francois, Verdier, Jean Francois, Dion, Jean Jacques, Haultier, Jean Jacques, Montseny, Jean Jacques, Bacri, Jean Louis, Bouchet, Jean Louis, Mahe, Jean Luc, Chalopin, Jean Marc, Gabriel, Jean Marc, Hurot, Jean Marc, Lanau, Jean Marc, Batho, Jean Marie, Coulibaly, Jean Marie, Hardin, Jean Michel, Marc, Jean Michel, Poux, Jean Michel, Rebibou, Jean Michel, Tivollier, Jean Michel, Ottavioli, Jean Noel, Faucon, Jean Paul, Imiela, Jean Paul, Jaulin, Jean Paul, Masselot, Jean Paul, Ortiz, Jean Paul, Bourdenx, Jean Philippe, Devaux, Jean Philippe, Hammelin, Jean Philippe, Rivory, Jean Pierre, Wauquier, Jean Pierre, Larue, Jean Rene, Mondain, Jean Rene, Borde, Jean Sebastien, Virot, Jean Simon, Bosc, Jean Yves, Achiche, Jedjiga, Parasote, Jennifer, Diolez, Jeremie, Harambat, Jerome, Potier, Jerome, Sampol, Jerome, Mustel, Jihad, Lefevre, Jean Jacques, Maurizi, Jocelyne, Gamberoni, Joel, Claudeon, Joelle, Terzic, Joelle, Rogol, Joffrey, Sayegh, Johnny, Cardozo, Jorge, Brasseur, Jose, Guiserix, Jose, Barsumau, Joseph, Albaret, Julie, Beaume, Julie, Attias, Julie Sohier, Dehay, Julien, Hogan, Julien, Journet, Julien, Ott, Julien, Baleynaud, Juliette, Bacchetta, Justine, Faucher, Justine, Yousfi, Kamel, Dardim, Karim, Clabault, Karine, Moreau, Karine, Thomas, Kedna, Sirajedine, Khaled, Chedid, Khalil, El Kaeoui, Khalil, El Karoui, Khalil, Bouachi, Khedidja, Hue, Kheira, El Nasser, Khuzama, Akposso, Kodso, Kunz, Kristian, Bijak, Krzysztof, Kihal, Lilia, Rasoloarijaona, L., Harbouche, Laid, Bencheikh, Larbi, Lamriben, Larbie, Hanafi, Latifa, Parvez, Laura Braun, Champion, Laure, Croze, Laure, Eprinchard, Laure, Patrier, Laure, Nicolet, Laurence, Vrigneaud, Laurence, Duflot, Laurent, Mackaya, Leandre, Chenine, Leila, Odry, Leon, Tamiji, Lili Taghipour, Bouzar, Lilia Antri, Nga Messi, Liliane Ngango, Le Mouellic, Lionel, Mandart, Lise, Weis, Lise, Pouteau, Lise Marie, Georgieva, Lora, Vitanova, Lorita, Chalabi, Lotfi, Delvallez, Luc, Frimat, Luc, Fromentin, Luc, Marty, Luc, Monjot, Luc, Spataru, Luciana, Bessenay, Lucie, Boissinot, Lucie, Wajsbrot, Lucie, Rakoff, Lucien, Lebourg, Ludivine, Perez, Lydie, Lafage, Lyliane, Azzouz, Lynda, Dumoulin, Madeleine, Ouziala, Messaoud, Joseph, Maan, Brahimi, Mabrouk, Fat, Maeva Wong, Fort, Magalie, Nakhla, Magued, Abtahi, Mahdi, Albadawy, Mahen, Alouach, Mahmoud, Mezghani, Mahmoud, Daroux, Maite, Boukelmoune, Maklouf, Dhib, Malek, Touam, Malik, Dubau, Malina, Balde, Mamadou, Khoa, Man Nguyen, Ismer, Manfred, Mehdi, Manolie, Laforet, Manon, Bouiller, Marc, Eugene, Marc, Fila, Marc, Hazzan, Marc, Kribs, Marc, Ladriere, Marc, Lebot, Marc, Padilla, Marc, Souid, Marc, Marraoui, Marcel, Burbach, Maren, Manescu, Maria, Noguera Gonzalez, Maria Eugenia, Revenco, Mariana, Terrasse, Marianne, Essi, Marie, Macher, Marie Alice, Nogier, Marie Beatrice, Cazin, Marie Cecile, Schweitzer Camoin, Marie Christine, Thouret, Marie Christine, Hannaert, Marie Claude, Servel, Marie France, Chabannier, Marie Helene, Coudert Krier, Marie Jeanne, Catoliquot, Marie Noelle, Guillodo, Marie Paule, Gavard, Marie Sophie, Vairon Codaccioni, Marie Xaviere, Rabec, Marina, Freist, Marine, Gauthier, Marion, Lemaire, Marion, Mehrenberger, Marion, Venot, Marion, Pongas, Marios, Diant, Marlene Beaubrun, Levannier, Martial, Bertaux, Martine, Jablonski, Mathieu, Sacquepee, Mathieu, Dargelos, Mathilde, Lemoine, Mathilde, Tamain, Mathilde, Monge, Matthieu, Reberolle, Matthieu, Cousin, Maud, Francois, Maud, Baron, Maurice, Hoffmann, Maxime, Ingwiller, Maxime, Touzot, Maxime, Mohajer, Mederick, Maaz, Mehadji, Hanoy, Melanie, Marroc, Melanie, Cuny, Melodie, Van Der Straaten, Menno, Serveaux, Mf., Basteri, Michel, Chong, Michel Fen, Hecht, Michel, Massad, Michel, Normand, Michel, Olmer, Michel, Tolani, Michel, Tsimaratos, Michel, Hemery, Michele, Kessler, Michele, Esposito, Miguel, Shenouda, Milad, Kareche, Mimi, Khalili, Mina, Diaconita, Mirella, Rifard, Mohamad Khair, Aladib, Mohamed, Belmouaz, Mohamed, Brahim, Mohamed, Diouani, Mohamed, Cherif, Mohamed Fodil, Jamali, Mohamed, Maghlaoua, Mohamed, Meddeb, Mohamed, Ramdane, Mohamed, Rifaat, Mohamed, Islam, Mohamed Sharifull, Abbade, Mohamed Adnan, Amrandi, Mokhtar, Chawki, Mokhtar, Ciobotaru, Monica, Indrieis, Monica, Chanas, Monique, Hoarau, Monique, Tomeh, Monzer, Bellou, Moufida, Bouzernidj, Mouloud, Ammor, Mounia, Guergour, Mounir, Benzakour, Mountassir, Hachicha, Mourad, Coulibaly, Moussa, Smati, Mustafa, Al Morabiti, Mustapha, Amirou, Mustapha, Isnard, Myriam, Pastural, Myriam, Pujo, Myriam, Boumendjel, Nourredine, Majbri, Nabil, Goumri, Nabila, Mingat, Nadege, Bassilios, Nader, Kerkeni, Nadia, Sedrati, Nadia, Soltani, Nadia, Maroun, Nadine, Neyrat, Nadine, Luang, Nahn, El Esper, Najeh, Ammar, Naji, Ghali, Nasredine, Hamdini, Nasser, Noel, Natacha, Potelune, Natacha, Maisonneuve, Nathalie, Pertuiset, Nathalie, Raynal, Nathalie, Vittoz, Nathalie, Terki, Nazim, Castin, Nelly, Nankeu, Nestor, Bouvier, Nicolas, Keller, Nicolas, Legros, Nicolas, Peters, Nicolas, Quirin, Nicolas, Lefrancois, Nicole, Monnier, Nicole, Rance, Nicole, Bruckmann, Niels, Mertens, Noel, Lorcy, Nolwenn, Gilbert, Olivia, Coldefy, Olivier, Drouineau, Olivier, Dunand, Olivier, Fritz, Olivier, Imhoff, Olivier, Kourilsky, Olivier, Lavelle, Olivier, Moranne, Olivier, Papin, Olivier, Roques, Olivier, Le Maner, Ophelie, Benbrahim, Oussamah Fikri, Erina Torres, Pablo Antonio, Urena Torres, Pablo Antonio, Malvezzi, Paolo, Bindi, Pascal, Cluzel, Pascal, Fontanier, Pascal, Wheatley, Pascal, Depraetre, Pascale, Dubosq, Pascale, Halin, Pascale, Sebahoun, Pascale, Siohan, Pascale, Testevuide, Pascale, Deteix, Patrice, Nolen, Patrice, Hue, Patricia, Lemarchand, Patricia, Donnadieu, Patrick, Fievet, Patrick, Fohrer, Patrick, Francais, Patrick, Giraud, Patrick, Hallonet, Patrick, Henri, Patrick, Michaut, Patrick, Michaut, Patrick, Niaudet, Patrick, Pauly, Patrick, Thomas, Patrick, Deleaval, Patrik, Finielz, Paul, Stroumza, Paul, Yverneau, Paule Hardy, Caillard, Pauline, Palacin, Pedro, Aubertin, Perrine, Attias, Philippe, Brunet, Philippe, Chauveau, Philippe, Coindre, Philippe, Coste, Philippe, Dubot, Philippe, Fournier, Philippe, Hiernaux, Philippe, Jousset, Philippe, Yue Wah, Philippe Lan, Lang, Philippe, Le Cacheux, Philippe, Dupont, Philippe Martin, Michel, Philippe, Mirgaine, Philippe, Moriniere, Philippe, Nicoud, Philippe, Rieu, Philippe, Rousseau, Philippe, Sporer, Philippe, Thorel, Philippe, Vanhille, 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Saingra, Yannick, Tirolien, Yannick, Mann, Youssef, Brunak, Yvan, Dimitrov, Yves, Doussy, Yves, Tanter, Yves, Benabid, Zaid, Soltani, Zaara, Boukerroucha, Zacharia, Takla, Zafer, Ramanantsialonina, Zana, Dickson, Zara, Tubail, Zead, Pour, Zoe Koochaki, Boukhalfa, Zohra, and Jacquot, Zohra

Abstract

The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. Our study included all patients on dialysis recorded in the French REIN Registry in April 2020. Clinical characteristics at last follow-up and the evolution of COVID-19 illness severity over time were recorded for diagnosed cases (either suspicious clinical symptoms, characteristic signs on the chest scan or a positive reverse transcription polymerase chain reaction) for SARS-CoV-2. A total of 1,621 infected patients were reported on the REIN registry from March 16th, 2020 to May 4th, 2020. Of these, 344 died. The prevalence of COVID-19 patients varied from less than 1% to 10% between regions. The probability of being a case was higher in males, patients with diabetes, those in need of assistance for transfer or treated at a self-care unit. Dialysis at home was associated with a lower probability of being infected as was being a smoker, a former smoker, having an active malignancy, or peripheral vascular disease. Mortality in diagnosed cases (21%) was associated with the same causes as in the general population. Higher age, hypoalbuminemia and the presence of an ischemic heart disease were statistically independently associated with a higher risk of death. Being treated at a selfcare unit was associated with a lower risk. Thus, our study showed a relatively low frequency of COVID-19 among dialysis patients contrary to what might have been assumed.

Published
2020
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15. The effects of cinacalcet in older and younger patients on hemodialysis: The evaluation of cinacalcet HCL therapy to lower cardiovascular events (EVOLVE) trial

Author

P. Ryckelynck, Y. Woredekal, T. Gehr, Marian Klinger, J. Passauer, K. Liss, E. Del Valle, B. Linares, Ferdinando Avella, Stolear Jc, S. Tolkan, O. Hermida, V. Wizemann, Ricardo Correa-Rotter, J. Santos, Gert Mayer, Michael Anger, B. Pellegrino, B. Wikström, A. Ståhl, H. Al-Bander, Pedro Alejandro Gordan, Philip A. Kalra, E. Galindo-Ramos, Carmine Zoccali, G. Dolson, M. Eigner, Sanjay Dalal, G. Touchard, J Peeters, G. Da Roza, Shannon Murphy, R. Errico, M. Lonergan, A. Andrusev, H. Boulechfar, P. Zaoui, Michael Suranyi, de Francisco Martín de Francisco, S. Jacobson, B. Gupta, C. Stafford, J. Picollo de Oliveira, Ilka Regina Souza de Oliveira, F. Dumler, J. Martinez Saye, E. de Almeida Romão, Emmanuel A. Burdmann, C. Vermeij, N. Kumar, E. Shahmir, J. Stratton, R. Schmidt, Mario Cozzolino, Lars Christian Rump, Rainer Oberbauer, J. Kumar, M. Saklayen, Brian Hutchison, C. Denu-Ciocca, L. Weiss, E. Friedman, L. Renders, K. Gurevich, L. Brandi, W. Shapiro, Kym M. Bannister, K. Berta, Muhammad M. Yaqoob, C. Lok, A. Pedrosa, Rosa M.A. Moysés, K. Bhandari, J. Arrieta, T. Crouch, Brigitte Maes, G. Wong, Myriam González, Matthew R. P. Davies, R. Gonzalez, Geoffrey A. Block, T. Nammour, T. Youell, J. Ramirez, S. Tobe, N. Ramirez, T. Bochicchio-Ricardelli, J. Cangiano-Rivera, D. Streja, J. Endsley, K. Ang, R. Patak, J. Cheng, T. Rogers, Alberto Albertazzi, H. Holzer, G. Choukroun, Jose A.L. Arruda, Philippe Rieu, P. Simon, Stephen Z. Fadem, Jared G. Sugihara, H. Alfred, Bruce F. Culleton, G. Frascà, Giovanni Pertosa, W. Van Kuijk, H. Beresan, Samuel S. Blumenthal, Piergiorgio Messa, H. Baer, Michael C. Braun, B. Rutkowski, W. Riegel, M. Komandenko, V. Ermolenko, Martin Wilkie, N. Muirhead, Peter G. Kerr, D. Rattensberger, J. Sabto, Anjay Rastogi, L. Lef, M. El Shahawy, D. Tharpe, A. Smirnov, J. Pons, F. García, F. Zantvoort, A. Lionet, J. Topf, Marcia R. Silver, Reinhard Kramar, E. Moriero, A. Rekhi, S. Roe, P. Batista, E. Kolmakova, F. Rahim, M. Ostrowski, Janice P. Lea, Patrizia Ondei, C. Martinez, J. Donck, Nicole Lopez, F. Schena, Allen R. Nissenson, Alex P.S. Disney, R. Valtuille, C. Najun Zarazaga, M. Fraenkel, Pieter Evenepoel, R. Cottiero, S. Di Giulio, V. Gura, S. Karunakaran, P. Nader, F. Saldanha Thome, Walter Douthat, A. Fekete, L. Arbeit, W. Sulowicz, I. Marin, Charles R.V. Tomson, Andrzej Wiecek, Luis A. Juncos, G. Mingardi, P. Light, Max Dratwa, H. Reichel, R. Raja, U. Ranjit, G. Sterner, E. Coll Piera, P. Pai, Robert J. Walker, R. Bregman, E. Hübel, M. Timofeev, T. Szabo, A. Elli, N. Padmanabhan, N. Garrote, M. Mysliwiec, David C. Wheeler, J. Cruz-Valdez, R. Klauser, Maree-Ross Smith, Antonio Carlos Carvalho, A. Losito, M. Durlik, G. Petraglia, Gianni Cappelli, Y. Lien, M. Chaffin, N. García, R. Halligan, Glenn M. Chertow, M. Bastos, P. Smak Gregoor, S. Ong, M. Belledonne, Fredric O. Finkelstein, J. Martínez García, R. Pecoits Filho, M. Klingberg, B. Carvalho, S. Noble, T. Plumb, A. 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Moriero, E., Cannella, G., Ortalda, V., Stefoni, S., Frasca, G., Cappelli, G., Albertazzi, A., Zoccali, C., Farina, M., Elli, A., Avella, F., Ondei, P., Mingardi, G., Errico, R., Losito, A., Di Giulio, S., Pertosa, G., Schena, F., Grandaliano, G., Gesualdo, L., Auricchio, M., Bochicchio-Ricardelli, T., Aranda Verastegui, F., Pena, J., Chew Wong, A., Cruz-Valdez, J., Torres Zamora, M., Solis, M., Sebastian Diaz, M., Vital Flores, M., Alvarez Sandoval, E., van den Dorpel, M., Brink, H., Van Kuijk, W., Vermeij, C., Smak Gregoor, P., Hagen, E., van der Sande, F., Klinger, M., Nowicki, M., Muszytowski, M., Bidas, K., Bentkowski, W., Wiecek, A., Ksiazek, A., Marczewski, K., Ostrowski, M., Switalski, M., Sulowicz, W., Matuszkiewicz-Rowinska, J., Mysliwiec, M., Durlik, M., Rutkowski, B., Macario, F., Carvalho, B., Frazao, J., Machado, D., Weigert, A., Andrusev, A., Khrustalev, O., Zemtchenkov, A., Gurevich, K., Staroselsky, K., Khadikova, N., Rozhinskaya, L., Timokhovskaya, G., Strokov, A., Balkarova, O., Ermolenko, V., Kolmakova, E., Komandenko, M., Timofeev, M., Shilo, V., Shostka, G., Smirnov, A., Anashkin, V., Volgina, G., Domashenko, O., Gurevich, A., Perlin, D., Martinez Garcia, J., Andres Ribes, E., Coll Piera, E., Fernandez Lucas, M., Galicia, M., Prados, M., Gonzalez, M., Romero, R., Martin de Francisco, A., Montenegro, J., Santiago, C., Garcia, F., Alcazar de La Ossa, J., Arrieta, J., Pons, J., Martin-Malo, A., Soler Amigo, J., Cases, A., Sterner, G., Jensen, G., Wikstrom, B., Jacobson, S., Lund, U., Weiss, L., Stahl, A., von Albertini, B., Burnier, M., Meier, P., Martin, P., Uehlinger, D., Dickenmann, M., Yaqoob, M., Zehnder, D., Kalra, P., Padmanabhan, N., Roe, S., Eadington, D., Pritchard, N., Hutchison, A., Davies, S., Wilkie, M., Davies, M., Pai, P., Swift, P., Kwan, J., Goldsmith, D., Tomson, C., Stratton, J., Dasgupta, I., Sarkar, S., Moustafa, M., Gandhi, K., Jamal, A., Galindo-Ramos, E., Tuazon, J., Batlle, D., Tucker, K., Schiller-Moran, B., Assefi, A., Martinez, C., Samuels, L., Goldman, J., Cangiano-Rivera, J., Darwish, R., Lee, M., Topf, J., Kapatkin, K., Baer, H., Kopelman, R., Acharya, M., Tharpe, D., Bernardo, M., Nader, P., Guzman-Rivera, J., Pergola, P., Sekkarie, M., Alas, E., Zager, P., Liss, K., Navarro, J., Roppolo, M., Denu-Ciocca, C., Kshirsagar, A., El Khatib, M., Kant, K., Scott, D., Murthyr, B., Finkelstein, F., Keightley, G., Mccrary, R., Pitone, J., Cavalieri, T., Tsang, A., Pellegrino, B., Schmidt, R., Ahmad, S., Brown, C., Friedman, E., Mittman, N., Fadem, S., Shapiro, W., Reddy, M., Goldberger, S., Woredekal, Y., Agarwal, A., Anger, M., Haque, M., Chidester, P., Kohli, R., Rubinstein, S., Newman, G., Gladish, R., Ayodeji, O., Soman, S., Sprague, S., Hunt, N., Gehr, T., Rizk, D., Warnock, D., Polack, D., Pahl, M., Fischer, D., Dreyer, P., James, G., Husserl, F., Rogers, T., Raff, A., Sedor, J., Silver, M., Smith, M., Steinberg, S., Delgiorno, T., Jones, E., Cunha, P. D., Cheng, J., Pogue, V., Blumenthal, S., Brown, E., Charytan, C., Buerkert, J., Cook, M., Felsenfeld, A., Tareen, N., Gupta, A., Herman, T., Diamond, S., Hura, C., Laski, M., Maclaurin, J., Plumb, T., Brosnahan, G., Kumar, J., Henriquez, M., Poole, C., Osanloo, E., Matalon, A., Sholer, C., Arfeen, S., Azer, M., Belledonne, M., Gross, M., Dunnigan, E., Mcconnell, K., Becker, B., Skinner, F., Rigolosi, R., Spiegel, D., Stegman, M., Patak, R., Streja, D., Ranjit, U., Youell, T., Wooldridge, T., Stafford, C., Cottiero, R., Weinberg, M., Schonefeld, M., Shahmir, E., Hazzan, A., Ashfaq, A., Bhandari, K., Cleveland, W., Culpepper, M., Golden, J., Lai, L., Lien, Y., Lorica, V., Robertson, J., Malireddi, K., Morse, S., Thakur, V., Israelit, A., Raguram, P., Alfred, H., Weise, W., Al-Saghir, F., El Shahawy, M., Rastogi, A., Nissenson, A., Kopyt, N., Lynn, R., Lea, J., Mcclellan, W., Teredesai, P., Ong, S., Tolkan, S., Sugihara, J., Minga, T., Mehrotra, R., Minasian, R., Bhatia, D., Specter, R., Capelli, J., Sidhu, P., Dalal, S., Dykes, P., Khan, M., Rahim, F., Saklayen, M., Thomas, A., Michael, B., Torres, M., Al-Bander, H., Murray, B., Abukurah, A., Gupta, B., Nosrati, S., Raja, R., Zeig, S., Braun, M., Amatya, A., Endsley, J., Sharon, Z., Dolson, G., Dumler, F., Ntoso, K., Rosansky, S., Kumar, N., Gura, V., Thompson, N., Goldfarb, D., Halligan, R., Middleton, J., Widerhorn, A., Arbeit, L., Arruda, J., Crouch, T., Friedman, L., Khokhar, S., Mittleman, J., Light, P., Taparia, B., West, C., Cotton, J., Dhingra, R., Kleinman, L., Arif, F., Lew, S., Nammour, T., Sterrett, J., Williams, M., Ramirez, J., Rubin, J., Mccarthy, J., Noble, S., Chaffin, M., and Rekhi, A.

Subjects
Parathyroidectomy, Adult, Male, medicine.medical_specialty, Cinacalcet, Epidemiology, medicine.medical_treatment, Calcimimetic Agents, Critical Care and Intensive Care Medicine, Lower risk, Severity of Illness Index, CKD, cardiovascular disease, hemodialysis, hyperparathyroidism, mineral metabolism, Age Factors, Aged, Aged, 80 and over, Cardiovascular Diseases, Cinacalcet Hydrochloride, Female, Humans, Hyperparathyroidism, Secondary, Kidney Failure, Chronic, Kidney Transplantation, Middle Aged, Renal Dialysis, Nephrology, Transplantation, Internal medicine, medicine, Intensive care medicine, Hyperparathyroidism, business.industry, Original Articles, medicine.disease, Secondary hyperparathyroidism, Hemodialysis, business, medicine.drug
Abstract

Background andobjectivesThecalcimimeticcinacalcet reduced therisk of death or cardiovascular (CV) events in older, but not younger, patients with moderate to severe secondary hyperparathyroidism (HPT) who were receiving hemodialysis. To determine whether the lower risk in younger patients might be due to lower baseline CV risk and more frequent use of cointerventions that reduce parathyroid hormone (kidney transplantation, parathyroidectomy, and commercial cinacalcet use), this study examined the effects of cinacalcet in older ($65 years, n=1005) and younger (,65 years, n=2878) patients. Design, setting, participants, & measurements Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) was a global, multicenter, randomized placebo-controlled trial in 3883 prevalent patients on hemodialysis, whose outcomes included death, major CV events, and development of severe unremitting HPT. The age subgroup analysis was prespecified. ResultsOlderpatients hadhigher baselineprevalenceof diabetesmellitusandCV comorbidity. Annualizedrates of kidney transplantation and parathyroidectomy were .3-fold higher in younger relative to older patients and were more frequent in patients randomized to placebo. In older patients, the adjusted relative hazard (95% confidence interval) for the primary composite (CV) end point (cinacalcet versus placebo) was 0.70 (0.60 to 0.81); in younger patients, the relative hazard was 0.97 (0.86 to 1.09). Corresponding adjusted relative hazards for mortality were 0.68 (0.51 to 0.81) and 0.99 (0.86 to 1.13). Reduction in the risk of severe unremitting HPT was similar in both groups. Conclusions In the EVOLVE trial, cinacalcet decreased the risk of death and of major CV events in older, but not younger, patients with moderate to severe HPT who were receiving hemodialysis. Effect modification by age may be partly explained by differences in underlying CV risk and differential application of cointerventions that reduce parathyroid hormone. Clin J Am Soc Nephrol 10: ccc–ccc, 2015. doi: 10.2215/CJN.07730814

Published
2015

16. Dietary Patterns and Mortality in a Multinational Cohort of Adults Receiving Hemodialysis

Author

Saglimbene, Valeria M., Wong, Germaine, Teixeira-Pinto, Armando, Ruospo, Marinella, Garcia-Larsen, Vanessa, Palmer, Suetonia C., Natale, Patrizia, Campbell, Katrina, Carrero, Juan-Jesus, Stenvinkel, Peter, Gargano, Letizia, Murgo, Angelo M., Johnson, David W., Tonelli, Marcello, Gelfman, Rubén, Celia, Eduardo, Ecder, Tevfik, Bernat, Amparo G., Del Castillo, Domingo, Timofte, Delia, Török, Marietta, Bednarek-Skublewska, Anna, Duława, Jan, Stroumza, Paul, Hansis, Martin, Fabricius, Elisabeth, Felaco, Paolo, Wollheim, Charlotta, Hegbrant, Jörgen, Craig, Jonathan C., Strippoli, Giovanni F.M., Badino, A., Petracci, L., Villareal, C., Soto, M., Arias, M., Vera, F., Quispe, V., Morales, S., Bueno, D., Bargna, R., Peñaloza, G., Alcalde, L., Dayer, J., Milán, A., Centurión, N., Ramos, A., De Orta, E., Menardi, S., Austa Bel, N., Marileo, E., Junqueras, N., Favalli, C., Trioni, R., Valle, G., López, M., Marinaro, C., Fernandez, A., Corral, J., Nattiello, E., Marone, S., García, J., Carrizo, G., González, P., Delicia, O., Maza, M., Chauque, M., Mora, J., Grbavac, D., López, L., Alonso, M., Villalba, C., Simon, M., Cernadas, M., Moscatelli, C., Vilamajó, I., Tursky, C., Martínez, M., Villalba, F., Pereira, D., Araujo, S., López, H., Alonso, V., Vázquez, B., Rapetti, M., Raña, S., Capdevila, M., Ljubich, C., Acosta, M., Coombes, M., Doria, V., Ávila, M., Cáceres, D., Geandet, E., Romero, C., Morales, E., Recalde, C., Marone, S., Casanú, M., Lococo, B., Da Cruz, O., Focsaner, C., Galarce, D., Albarracín, L., Vescovo, E., Gravielle, M., Florio, D., Baumgart, L., Corbalán, M., Aguilera, V., Hermida, O., Galli, C., Ziombra, L., Gutierrez, A., Frydelund, S., Hardaman, A., Maciel, A., Arrigo, M., Mato Mira, C., Leibovich, J., Paparone, R., Muller, E., Malimar, A., Leocadio, I., Cruz, W., Tirado, S., Peñalba, A., Cejas, R., Mansilla, S., Campos, C., Abrego, E., Chávez, P., Corpacci, G., Echavarría, A., Engler, C., Vergara, P., Hubeli, M., Redondo, G., Noroña, B., Boriceanu, C., Lankester, M., Poignet, J.L., Saingra, Y., Indreies, M., Santini, J., Mahi, A., Robert, A., Bouvier, P., Merzouk, T., Villemain, F., Pajot, A., Tollis, F., Brahim-Bounab, M., Benmoussa, A., Albitar, S., Guimont, M.C., Ciobotaru, P., Guerin, A., Diaconita, M., Hoischen, S.H., Saupe, J., Ullmann, I., Grosser, S., Kunow, J., Grueger, S., Bischoff, D., Benders, J., Worch, P., Pfab, T., Kamin, N., Roesch, M., May, M., Albert, K., Csaszar, I., Kiss, E., Kosa, D., Orosz, A., Redl, J., Kovacs, L., Varga, E., Szabo, M., Magyar, K., Zajko, E., Bereczki, A., Csikos, J., Kerekes, E., Mike, A., Steiner, K., Nemeth, E., Tolnai, K., Toth, A., Vinczene, J., Szummer, S.z., Tanyi, E., Szilvia, M., Murgo, A.M., Sanfilippo, N., Dambrosio, N., Saturno, C., Matera, G., Benevento, M., Greco, V., di Leo, G., Papagni, S., Alicino, F., Marangelli, A., Pedone, F., Cagnazzo, A.V., Antinoro, R., Sambati, M.L., Donatelli, C., Ranieri, F., Torsello, F., Steri, P., Riccardi, C., Flammini, A., Moscardelli, L., Boccia, E., Mantuano, M., Di Toro Mammarella, R., Meconizzi, M., Fichera, R., D’Angelo, A., Latassa, G., Molino, A., Fici, M., Lupo, A., Montalto, G., Messina, S., Capostagno, C., Randazzo, G., Pagano, S., Marino, G., Rallo, D., Maniscalco, A., Trovato, O.M., Strano, C., Failla, A., Bua, A., Campo, S., Nasisi, P., Salerno, A., Laudani, S., Grippaldi, F., Bertino, D., Di Benedetto, D.V., Puglisi, A., Chiarenza, S., Lentini Deuscit, M., Incardona, C.M., Scuto, G., Todaro, C., Dino, A., Novello, D., Coco, A., Bocheńska-Nowacka, E., Jaroszyński, A., Drabik, J., Wypych-Birecka, M., Daniewska, D., Drobisz, M., Doskocz, K., Wyrwicz-Zielińska, G., Kosicki, A., Ślizień, W., Rutkowski, P., Arentowicz, S., Dzimira, S., Grabowska, M., Ostrowski, J., Całka, A., Grzegorczyk, T., Dżugan, W., Mazur, M., Myślicki, M., Piechowska, M., Kozicka, D., de Sá Martins, V., Aguiar, L., Mira, A.R., Velez, B., Pinheiro, T., Agapi, E., Ardelean, C.L., Baidog, A., Bako, G., Barb, M., Blaga, A., Bodurian, E., Bumbea, V., Dragan, E., Dumitrache, D., Florescu, L., Havasi, N., Hint, S., Ilies, R., Mandita, A.G.M., Marian, R.I., Medrihan, S.L., Mitea, L., Mitea, S., Mocanu, R., Moro, D.C., Nitu, M., Popa, M.L., Popa, M., Railean, E., Scuturdean, A.R., Szentendrey, K., Teodoru, C.L., Varga, A., García, M., Olaya, M., Abujder, V., Carreras, J., López, A., Ros, F., Cuesta, G., García, A., Orero, E., Ros, E., Bea, S., Pizarro, J.L., Luengo, S., Romero, A., Navarro, M., Cermeño, L., Rodriguez, A., Lopez, D., Barrera, A., Montoya, F., Tajahuerce, J., Carro, M., Cunill, M.Q., Narci, S., Ballester, T., Soler, M.J., Traver, S., Buta, P.P., Cucuiat, L., Rosu, L., Garcia, I., Gavra, C.M., Gonzalez, R., Filimon, S., Peñalver, M., Benages, V., Cardo, M.I., García, E., Soler, P., Fernnandez, E., Popescu, F., Munteanu, R., Tanase, E., Sagau, F., Prades, D., Esteller, S., Gonzalez, E., Martinez, R., Diago, A., Torres, J., Perez, E., Garcia, C., Lluch, I., Forcano, J., Fóns, M., Rodríguez, A., Millán, N.A., Fernández, J., Ferreiro, B., Otero, M., Pesqueira, V., Abal, S., Álvarez, R., Jorge, C., Rico, I., de Dios Ramiro, J., Duzy, L., Soto, A., Lopez, J.L., Diaz, Y., Herrero, I., Farré, M., Blasco, C., Ferrás, S., Agost, M.J., Miracle, C., Farto, J., Goch, J., Katzarski, K.S., Wulcan, A., Akbiber, H., Arslan, H., Bicen, L., Buyukkiraz, A., Celik, R., Dogan, I.S., Erkalkan, S., Ertas, A., Hark, U., Iravul, E., Karakaya, M., Mengu, K., Ongun, S., Ozkan, Z., Ozlu, A., Ozveren, N., Sifil, H.M., Sonmez Turksoz, N., and Yilmaz, Z.

Abstract

Clinical practice guidelines for dietary intake in hemodialysis focus on individual nutrients. Little is known about associations of dietary patterns with survival. We evaluated the associations of dietary patterns with cardiovascular and all-cause mortality among adults treated by hemodialysis.

Published
2020
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17. Experimental study of pedicled subcostal artery perforator (SCAP) flap: A new application in breast reconstruction.

Author

Delchet, Ophelie, Majoulet, Laurene, Avisse, Claude, and Stroumza, Nathaniel

Abstract

Latissimus dorsi flap is the gold standard for pedicled breast reconstruction but is limited by donor site scarring, which is difficult to conceal, and a high rate of post-operative seroma. We investigated the anatomic characteristics and feasibility of using a subcostal artery perforator (SCAP) flap, which was taken from the flank area and vascularised by a perforator artery through a subcostal pedicle, for a breast reconstruction. A literature review was undertaken to determine the anatomy of the SCAP flap pedicle and the vascular supply to this dermal-fat flap. Pedicled SCAP flaps were dissected on cadavers to identify the anatomy of the perforator arteries and the pedicle length. Pedicled SCAP flaps were then tunnelled through the chest area to evaluate their feasibility for breast reconstruction. Twelve SCAP flaps were prepared on six cadavers. Mean pedicle length was 17 cm (14.5–20 cm). Mean flap size was 13 × 18 cm (11.5 × 15.5–15 × 21 cm). For each flap, a pedicle of sufficient length was dissected to allow the tunnelling of the flap and to perform breast reconstruction with a dermal-fat flap of adequate size. In all cases, an SCAP flap was prepared, without taking muscle, to reduce the risk of parietal complications at the donor site in future clinical applications. Pedicled SCAP flap is a feasible option in breast reconstruction and could represent a less arduous surgical alternative to free flaps for some patients. Donor site scarring was acceptable. Clinical application of SCAP flaps should be investigated further. [ABSTRACT FROM AUTHOR]

Published
2019
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18. Serum lipoprotein changes after prolonged intralipid infusion in malnourished haemodialysis patients

Author

G. Luc, J.P. Durbec, Noël Cano, P. Stroumza, and P. Lacombe

Subjects
medicine.medical_specialty, Nutrition and Dietetics, Apolipoprotein B, biology, business.industry, Triglyceride transport, medicine.medical_treatment, Lipid metabolism, Critical Care and Intensive Care Medicine, Fat emulsion, Endocrinology, Internal medicine, biology.protein, medicine, lipids (amino acids, peptides, and proteins), Hemodialysis, business, Lipid infusion, Dialysis, Lipoprotein
Abstract

Fat emulsions have been shown to be on efficient source of energy support in malnourished haemodialysis patients. This work was conducted in order to study the effect of prolonged intralipid infusion, during dialysis, on lipid metabolism. The following fasting serum parameters were measured before and after a 1 month infusion of 20% Intralipid (67 kJ/kg body wt/dialysis) in 10 malnourished patients undergoing dialysis: total cholesterol, triglycerides, phospholipids, HDL-cholesterol, LDL-cholesterol, HDL2-cholesterol, HDL3-cholesterol, apolipoproteins A-I, A-II, A-IV, C-II, C-III, and lipoproteins A-I, A-I A-II, EB and (a). After prolonged lipid infusion, the apoprotein B (p < 0.05) and C-II (p < 0.005) increased suggesting a triglyceride transport activation. Apolipoprotein A-I (p < 0.05) and lipoprotein A-I (p < 0.05) decreased without a change in total cholesterol. Lipoprotein (a) decreased in each case (p < 0.005), suggesting a reduction of its related risk of atherogenesis.

Published
1994

19. L’insuffisance cardiaque et le déficit en 25OH Vit D, facteurs de résistance aux agents stimulant l’érythropoïèse (ASE) ?

Author

Laurent Juillard, Bertrand Dussol, Eric Daugas, Dominique Joly, Gabriel Choukroun, P. Stroumza, Georges Mourad, and P. Henri

Subjects
Nephrology
Abstract

Introduction PREDICT est une enquete transversale conduite aupres de 86 nephrologues francais qui visait a mettre en evidence le(s) facteur(s) de resistance aux ASE chez les patients ayant une maladie renale chronique stades 3 et 4. Un questionnaire comportant les donnees demographiques et biologiques d’interet etait renseigne pour chaque malade ayant beneficie de l’initiation d’un traitement par ASE entre le 1/1/2011 et le 31/7/2013. La resistance aux ASE etait definie par une augmentation de l’Hb [1] . Patients et methodes Parmi les 695 malades inclus, 422 avaient des donnees exploitables a M1. Il n’y avait pas de differences demographiques ou biologiques entre les 422 malades exploitables et les 273 malades non exploitables. Les patients etaient âges de 76 ans (67–82), 56 % etait des hommes, avec un IMC a 26 kg/m2 (23–29), 44 % avait une nephropathie vasculaire, 28 % une GNC (dont 68 % 2aire a un diabete), 9 % une NIC, 5 % une polykystose et 14 % une nephropathie indeterminee. Parmi les 422 malades, 61 (14 %) etaient non repondeurs aux ASE et 361 (86 %) etaient repondeurs. En analyse univariee, il n’y avait pas de difference entre les 2 populations concernant l’âge, le sexe, la frequence de la nephropathie, de l’HTA ou du diabete, les facteurs de risque et les complications cardiovasculaires, les neoplasies ou hemopathies, et le traitement par AVK ou par fer ou vitamines B9, B12, D et C. Il n’y avait pas non plus de difference entre les 2 populations pour les molecules et les posologies d’ASE, et les variables biologiques comme la fonction renale, les parametres du bilan phosphocalcique ou d’inflammation, et la ferritinemie. Par contre l’insuffisance cardiaque etait plus frequente (38 % vs 21 %, p Discussion et conclusion Au total, cette enquete met possiblement en evidence l’insuffisance cardiaque et les taux seriques bas de 25OH Vit D comme facteurs de resistance aux ASE. Ces resultats doivent etre confirmes par une analyse multivariee et d’autres analyses basees sur une definition de la resistance aux ASE plus pertinente que celle de Solomon.

Published
2014

20. Santé bucco-dentaire et mortalité totale et cardiovasculaire chez le patient hémodialysé : ORAL-D une étude de cohorte multinationale

Author

L. Frantzen, Giovanni F.M. Strippoli, S. Trendel, and P. Stroumza

Subjects
Nephrology
Abstract

Introduction Les affections bucco-dentaires sont plus severes chez les patients dialyses par rapport a la population generale. Pourtant, leur prise en charge est souvent tres limitee. Patients et methodes Dans ORAL-D, une etude de cohorte prospective multinationale, 4320 patients hemodialyses (âge moyen de 61,7 ans et 57,7 % de sexe masculin) ont beneficie d’un examen bucco-dentaire complet et ont ete interroges sur leurs pratiques d’hygiene bucco-dentaire. Nous avons etudie l’association entre sante/hygiene bucco-dentaire et mortalite globale/cardiovasculaire en stratifiant par pays et en ajustant pour l’âge, le sexe, les revenus, le tabagisme, les maladies cardiovasculaires, le diabete, la pression arterielle, le temps passe en dialyse et la phosphoremie. Resultats Durant l’etude (suivi median de 22,1 mois), on denombre 650 deces, dont 325 sont d’origine cardiovasculaire. Apres ajustement, le risque de deces augmente de facon significative chez les 982 (23 % de la cohorte) patients edentes (HR a 1,27 ; IC 95 % de 1,10–1,46). De facon similaire chez les patients non edentes, un score CAO (pour dents Cariees, Absentes ou Obturees) superieur > 12 predit egalement une surmortalite (HR a 1,46 ; IC 95 % de 1,22–1,74). Chez les patients non edentes, le brossage regulier (0,74 ; 0,59–0,94), l’utilisation de fil dentaire (0,49 ; 0,32–0,79), le changement de la brosse a dents au moins tous les 3 mois (0,79 ; 0,66–0,94) et globalement le fait de consacrer de facon quotidienne plus de 2 minutes a son hygiene bucco-dentaire (0,81 ; 0,69–0,95) sont associes a une meilleure survie globale avec des chiffres quasiment superposables pour la mortalite cardiovasculaire. Pour les patients > 60 ans, l’association entre le score CAO et mortalite reste significative mais est un peu plus faible (1,31 ; 1,07–1,60). Discussion et conclusion L’etude ORAL-D met en evidence une association independante entre une moindre sante bucco-dentaire et la mortalite globale et cardiovasculaire chez l’adulte en hemodialyse. D’un autre cote, une bonne hygiene bucco-dentaire est liee a une meilleure survie.

Published
2014

21. Perdialytic parenteral nutrition with lipids and amino acids in malnourished hemodialysis patients

Author

P. Lacombe, L Cynober, P. Stroumza, Noël Cano, J Labastie-Coeyrehourq, J di Costanzo-Dufetel, C Coudray-Lucas, and J P Durbec

Subjects
Adult, Parenteral Nutrition, medicine.medical_specialty, Apolipoprotein B, Nutritional Status, Medicine (miscellaneous), chemistry.chemical_compound, Renal Dialysis, Internal medicine, medicine, Humans, Amino Acids, Intradialytic parenteral nutrition, PDPN, Aged, Creatinine, Nutrition and Dietetics, Triglyceride, biology, Cholesterol, business.industry, Middle Aged, Lipids, Nutrition Disorders, Surgery, Parenteral nutrition, Endocrinology, chemistry, biology.protein, Leucine, business
Abstract

A 3-mo perdialytic parenteral nutrition (PDPN) regimen was tested in 26 malnourished adults receiving hemodialysis (HD). Subjects were randomly assigned to receive PDPN (n = 12) or not to receive it (n = 14). PDPN was intravenously infused three times a week during HD; each infusion was made up of 1.6 g fat/kg body wt, 0.08 g N/kg body wt, essential and nonessential amino acids, and glycyl-tyrosine. PDPN, together with a PDPN-induced increase in spontaneous eating, increased intakes from 30 +/- 8.4 kcal.kg body wt-1.d-1 (mean +/- SD) and 1 +/- 0.27 g protein.kg body wt-1.d-1 to 39 +/- 8.5 kcal.kg body wt-1.d-1 and 1.25 +/- 0.30 g protein.kg body wt-1.d-1. Compared with control subjects, PDPN patients were characterized by increases in body weight (P less than 0.01), arm-muscle circumference (P less than 0.02), serum transthyretin and albumin concentrations (P less than 0.05), interdialytic creatinine appearance (P less than 0.01), skin-test reactivity (P less than 0.02), plasma leucine (P less than 0.05) without modifications of other amino acids, and plasma apolipoprotein A-I (P less than 0.01) without significant changes in apolipoprotein B, cholesterol, triglyceride, and phospholipid concentrations. Thus, PDPN appeared to be effective and safe with respect to plasma lipids.

Published
1990

22. Treatment of Progressive Systemic Sclerosis by Plasma Exchange: Long-term Results in 40 Patients

Author

L. Guillevin, Z. Amoura, Ph. Merviel, J. Pourrat, A. Bussel, A. Sobel, T. Khuy, A. Houssin, D. Alcalay, P. Stroumza, F. Sanderson, G. Levy, G. Frey, and K.S. Ang

Subjects
medicine.medical_specialty, Lung, business.industry, 030232 urology & nephrology, Biomedical Engineering, Medicine (miscellaneous), Progressive systemic sclerosis, Bioengineering, Captopril, General Medicine, Long term results, 030204 cardiovascular system & hematology, Factor XIII, medicine.disease, Scleroderma, Biomaterials, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Nifedipine, Internal medicine, Concomitant, Medicine, business, medicine.drug
Abstract

The efficacy of plasma exchanges (PE) during the course of scleroderma has only been investigated for short periods. The aim of this study was to follow patients over a long enough period to observe the course of the clinical and paraclinical symptoms in the short, medium, and long term. Forty patients, 24 women and 16 men, were treated by PE and observed for 1–3, 3–12 and over 12 months. Immunological, biological and clinical course and any undesirable side effects were evaluated using a detailed questionnaire. Concomitant therapies were reported and most frequently consisted of corticosteroids, colchicine, factor XIII or vasodilators (nifedipine, captopril). The therapeutic effectiveness of PE was assessed on the basis of improvements in cutaneous, digestive, joint, muscular, lung, cardiovascular and renal lesions. Our findings confirmed the effectiveness of short-term PE on scleroderma (52% of the patients improved during the first 3 months). However, this improvement was transient (5% improvement between 3 and 12 months and only 2.5% over 12 months) and limited to the cutaneous and muscular lesions. Thus, PE cannot be recommended for the treatment of progressive systemic sclerosis.

Published
1990

23. Dépression et mortalité cardiovasculaire en hémodialyse : une étude de cohorte multinationale

Author

Patrizia Natale, M. Scaldapane, J.C. Craig, P. Stroumza, V. Saglimbene, L. Gargano, L. Frantzen, Suetonia C. Palmer, J. Dulawa, Giovanni F.M. Strippoli, Marinella Ruospo, and Angelo M. Murgo

Subjects
Nephrology
Abstract

Introduction La depression est frequente chez les adultes en dialyse avec une prevalence d’environ 25 %. Des etudes montrent un lien entre la depression et la mortalite totale, mais l’association entre la depression et la mortalite cardiovasculaire est incertaine. Patients et methodes Nous avons etudie une cohorte multinationale prospective portant sur les adultes traites par hemodialyse iterative au sein d’un reseau mondial entre avril et novembre 2010. La depression a ete etudiee grâce au Beck Depression Inventory (BDI) II. Les tests de sensibilite considerent un BDI II ≥ 14 pour deceler une depression et BDI II ≥ 20 pour affirmer une depression severe. Le modele de regression de Cox a ete utilise pour evaluer les risques ajustes pour toutes causes et la mortalite cardiovasculaire a 12 mois. Resultats Parmi les 2278 (73 %) participants qui ont fourni des reponses completes aux questions de l’enquete BDI II, 1047 (46 %) des repondants ont signale des symptomes correspondant a la depression. Discussion Les facteurs associes a des symptomes depressifs comprenaient l’âge, le pays, l’emploi, l’education, le tabagisme, la comorbidite cardiovasculaire, la pression arterielle, la dose de dialyse et la prise de medicaments psychoactifs. Au cours du suivi de 11 mois (± 2,5), 175 deces sont survenus, dont 66 etaient attribuables a des causes cardiovasculaires. La depression (BDI ≥ 14) n’etait pas associee a la mortalite toutes causes confondues (HR ajuste 1,26 [IC 95 % de 0,93 a 1,71]) ou a la mortalite cardiovasculaire (0,82 [0,50 a 1,34]). Quand un score plus eleve (BDI ≥ 20) a ete utilise pour identifier la depression, la depression etait associee a une mortalite globale (1,40 [1,02 a 1,93]), tandis qu’une association avec la mortalite cardiovasculaire n’etait pas evidente (1,05 [0,63 a 1,77]). Conclusion La relation entre la depression et la mortalite cardiovasculaire chez les adultes traites par hemodialyse est incertaine. Les liens actuels entre la depression et les causes de mortalite sont influences par les parametres et les seuils utilises pour identifier les symptomes depressifs.

Published
2015

28. Thymic function is a major determinant of onset of antibody‐mediated rejection in heart transplantation

Author

Sannier, A., Stroumza, N., Caligiuri, G., Le Borgne‐Moynier, M., Andreata, F., Senemaud, J., Louedec, L., Even, G., Gaston, A. T., Deschildre, C., Couvelard, A., Ou, P., Cheynier, R., Nataf, P., Dorent, R., and Nicoletti, A.

Abstract

Thymic function decreases progressively with age but may be boosted in certain circumstances. We questioned whether heart transplantation was such a situation and whether thymic function was related to the onset of rejection. Twenty‐eight antithymocyte globulin–treated heart transplant recipients were included. Patients diagnosed for an antibody‐mediated rejection on endomyocardial biopsy had a higher proportion of circulating recent thymic emigrant CD4+ T cells and T cell receptor excision circle levels than other transplanted subjects. Thymus volume and density, assessed by computed tomography in a subset of patients, was also higher in patients experiencing antibody‐mediated rejection. We demonstrate that thymic function is a major determinant of onset of antibody‐mediated rejection and question whether thymectomy could be a prophylactic strategy to prevent alloimmune humoral responses. Heart transplant patients diagnosed with antibody‐mediated rejection display more thymic function as assessed through the quantification of recent thymic emigrants and T cell receptor excision circles as well as thoracic computed tomography.

Published
2018
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35. Les premiers pas de la posturographie en hémodialyse

Author

S. Mesure, B. Didier, L. Frantzen, and P. Stroumza

Subjects
Nephrology
Abstract

Introduction En hemodialyse, les chutes presentent un probleme recurrent devant une population vieillissante. La morbi-mortalite inherente a ces chutes est tres importante et leur prevention est donc capitale. Le but de ce travail est d’evaluer la posture sur un echantillon de patients dialyses. La posture est l’elaboration et le maintien actif de la configuration des differents segments du corps dans l’espace. Patients et methodes La posturographie est une methode d’investigation qui evalue a l’aide d’une plate-forme de pression la fonction d’equilibration statique et dynamique du patient. En collaboration avec notre kinesitherapeute et l’Institut des Sciences du Mouvement, nous avons inclus de facon aleatoire 23 patients dialysant depuis plus de 3 mois (12 femmes et 11 hommes, âge moyen de 74,5 ans) avec des mesures posturographiques (les yeux ouverts et fermes) pour les 3 seances de dialyse de la semaine avant et apres chaque seance. Resultats Nous constatons une augmentation (donc une degradation) significative des valeurs posturales des sujets dialyses par rapport aux normes posturographiques habituelles. Cette augmentation se retrouve au niveau de l’ensemble des parametres observables et classiquement reconnus comme representatifs des performances de controle postural des sujets. Ces parametres posturaux sont encore davantage deteriores les yeux fermes, en post-dialyse et lors de la 1 ere seance de la semaine. Discussion et conclusion Nos resultats suggerent que les sujets dialyses presentent une forte instabilite posturale en moyenne avec pour consequence un risque de chute important.

Published
2014

37. [Factors determining the choice of a modality of treatment by dialysis: a study of nine dialysis centers]

Author

P, Bataille, B, Coevoet, D, Cuvelier, C, Descoeudres, T, Drüeke, A, Moynot, J L, Poignet, J P, Ryckelynck, and P, Stroumza

Subjects
Renal Replacement Therapy, Cross-Sectional Studies, Hemodialysis Units, Hospital, Peritoneal Dialysis, Continuous Ambulatory, Hemodialysis, Home, Humans, Kidney Failure, Chronic, France, Peritoneal Dialysis, Switzerland
Abstract

The objective of this cross-sectional study in a population of 1472 dialysis patients was to identify the main factors involved in the choice of a specific option for dialysis therapy, taking into account three different types of criteria such as medical dependence (DM), nurse care requirement (SI) and independence for dialysis therapy (CA).Each patient has been analysed, independently of present treatment modality, according to the above three criteria, namely DM, SI and CA. For each type of parameter, patients have been allocated to one of three levels, each level being established to evaluate whether dialytic treatment should be undertaken as hospital centre dialysis (HDC) or in a facility off the hospital. Level 3 of any one category corresponded to the inability of doing haemodialysis at home (HHD) or in self-care unit (AD). Level 2 included patients who could be treated in AD or by peritoneal dialysis (PD) with the assistance of a nurse. CAPD or HHD were considered as potential treatment modalities only in patients qualifying for level 1 of each criterion.In the patient population as a whole, the following treatment options were observed: HHD 3.6%, CAPD 6%, PD 1.8%, AD 16.3% and HDC 72.2%. For medical dependence (DM) there was a relatively even distribution for the three levels in six centres. In contrast, two centres were characterized by a predominance of DM level 3. Differences in DM levels between centres were greatly reduced when considering separately only those patients who were actually treated by CAPD, HDC and AD. SI levels were more uniformly distributed within all centres, and this was true for HCD and AD patients. When considering CA levels in HDC patients, a large predominance of CA level 3 was observed in all centres whereas CA level 1 was nearly in existent.The major finding of this study was that the inability or the refusal of dialysis patients to participate at treatment, independently of medical condition and nurse care requirement, was the main factor in the choice of hospital centre dialysis.

Published
2000

38. [Management of malnutrition in chronic hemodialysis]

Author

N, Cano and P, Stroumza

Subjects
Parenteral Nutrition, Enteral Nutrition, Renal Dialysis, Humans, Kidney Failure, Chronic, Nutritional Status, Prognosis, Nutrition Disorders
Abstract

Malnutrition is an independent factor of morbidity and mortality in hemodialysis patients. Therefore, the nutritional management must be included in the follow-up and treatment of these patients. During hemodialysis, estimated nutritional requirements are 35-40 kcal/kg/day and 1.2-1.4 protein/kg/day. Dietary counseling, performed twice a year, makes it possible to detect the early signs of undernutrition. High risk malnutrition can be identified by the following indicators: normalized catabolic rate1 g/kg/j, serum albumin35 g/l, serum prealbumin300 mg/l. A trimestrial measurement of these variables is recommended. A schematic diagram is proposed for the nutritional management of malnourished hemodialysis patient. The occurrence of malnutrition implies to look for any cause of anorexia or hypercatabolism such as inadequate nutritional intakes, inadequate dialysis, severe anemia and depression. Nutritional supplementation must be adapted according to its ability to satisfy nutritional needs: oral supplements in patients with beginning undernutrition; intradialytic parental nutrition in patients with severe malnutrition and spontaneous intakes more than 20 kcal/kg/day; daily enteral nutrition when spontaneous intakes are less than 20 kcal/kg/day.

Published
1998

39. Visites médiatisées en protection de l’enfance : exploration et transformation des émotions des professionnels, des parents et des enfants

Author

Kim Stroumza, Marc Pittet, Anne-Françoise Pont, Sylvie Mezzena, Laetitia Krummenacher, Laurence Seferdjeli, Flavio Fersini, and Janette Friedrich

Subjects
social work, emotion, mediated visit, Social Sciences, Social pathology. Social and public welfare. Criminology, HV1-9960
Abstract

This article focuses on the activities of social workers during mediated visits in the context of child protection. Using an example, we describe how social workers work concretely during these visits to explore and transform the emotions experienced by all parties. They do so in the aim of encouraging the meeting between parent and child while fulfilling their missions to protect the child and support and evaluate parentality. In the example we analyse, the social worker speaks of the child’s emotion at the beginning of the visit, and by doing so, the emotions of both the father and the social worker are tacitly transformed. The professionals of this team explore and transform these emotions and experiment with different interpretations as they work to construct a common world, real, viable and shareable with the parents and children, in their presence and with their interventions.

40. Les moments de coprésence parents, enfants et professionnels dans un dispositif suisse de placement : ici et maintenant, entre les trois, l’air de rien, il se passe quelque chose d’important

Author

Kim Stroumza, Anne-Françoise Pont, Marc Pittet, Flavio Fersini, and Laetitia Krummenacher

Subjects
protection, participation, education, placement, ordinary, Social Sciences, Social pathology. Social and public welfare. Criminology, HV1-9960
Abstract

This article focuses on moments of co-presence between parents, children, and professionals (based on ordinary activities, such as games, meals, walks, etc.) within compulsory assistance apparatuses in the field of child protection, more specifically within a Swiss placement apparatus. We wager that, from an educational point of view, something very specific is played out in these moments and that in order fully to reap the benefits, it is necessary better to understand this dynamic. We contend that being present and participating in a moment of co-presence does not produce the same requirements nor provide the same opportunities as interview- or meeting-based apparatuses. It seems important to us to bring out these specificities with a view to supporting the extended forms of participation that are offered to parents and children.Taking a work analysis approach, enhanced by pragmatism and phenomenology, we therefore used a range of data (observations, 3 films, 6 “self-confrontation” interviews) to examine how professionals act in these moments in order to promote the best interests of the child. Our research allowed us, with the professionals, to model two ways of inhabiting these moments: Only one of these considers that in the here and now, between the three individuals, imperceptibly, something important is happening.

41. Un dilemme pratique à trancher depuis des valeurs logées dans l'activité Conséquences pour la connaissance et la professionnalité des éducateurs.

Author

Mezzena, Sylvie, Stroumza, Kim, and Kramer, Nicolas

Abstract

Copyright of Activités is the property of ARPACT and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016
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