1,246 results on '"P. Rivet"'
Search Results
2. Spin states of X-complex asteroids in the inner main belt -- I. Investigating the Athor and Zita collisional families
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Athanasopoulos, D., Hanuš, J., Avdellidou, C., van Belle, G., Ferrero, A., Bonamico, R., Gazeas, K., Delbo, M., Rivet, J. P., Apostolovska, G., Todorović, N., Novakovic, B., Bebekovska, E. V., Romanyuk, Y., Bolin, B. T., Zhou, W., and Agrusa, H.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The aim of our study is to characterise the spin states of the members of the Athor and Zita collisional families and test whether these members have a spin distribution consistent with a common origin from the break up of their respective family parent asteroids. Our method is based on the asteroid family evolution, which indicates that there should be a statistical predominance of retrograde-rotating asteroids on the inward side of family's V-shape, and prograde-rotating asteroids on the outward side. We used photometric data from our campaign and the literature in order to reveal the spin states of the asteroids belonging to these families. We combined dense and sparse photometric data in order to construct lightcurves; we performed the lightcurve inversion method to estimate the sidereal period, spin axis and convex shape of several family members. We obtained 34 new asteroid models for Athor family members and 17 for Zita family members. Along with the literature and revised models, the Athor family contains 60% of retrograde asteroids on the inward side and, 76% of prograde asteroids on the outward side. We also found that the Zita family exhibits 80% of retrograde asteroids on the inward side and an equal amount of prograde and retrograde rotators on the outward side. However, when we applied Kernel density estimation, we also found a clear peak for prograde asteroids on the outward side, as expected from the theory. The spin states of these asteroids validate the existence of both families, with the Athor family exhibiting a stronger signature for the presence of retrograde-rotating and prograde-rotating asteroids on the inner and outer side of the family, respectively. Our work provides an independent confirmation and characterisation of these very old families, whose presence and characteristics offer constraints for theories and models of the Solar System's evolution.
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- 2024
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3. On-sky demonstration of an ultra-fast intensity interferometry instrument utilising hybrid single photon counting detectors
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Leopold, Verena G., Karl, Sebastian, Rivet, Jean-Pierre, and von Zanthier, Joachim
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Intensity interferometry is a reemerging astronomical technique for performing high angular resolution studies at visible wavelengths, benefiting immensely from the recent improvements in (single) photon detection instrumentation. Contrary to direct imaging or amplitude interferometry, intensity interferometry correlates light intensities rather than light amplitudes, circumventing atmospheric seeing limitations at the cost of reduced sensitivity. In this paper we present measurements with the 1.04 m Omicron telescope of C2PU (Centre P\'edagogique Plan\`ete Univers) at the Calern Observatory in the south of France featuring hybrid single photon counting detectors (HPDs). We successfully measured photon bunching from temporal correlations of three different A-type stars - Vega, Altair and Deneb - in the blue at 405 nm. In all cases the observed coherence time fits well to both the pre-calculated expectations as well as the values measured in preceding laboratory tests. The best signal to noise ratio (SNR), with a value of 12, is obtained for Vega for an observation time of 12.1 h. The combination of HPDs and time to digital converter (TDC) results in a timing jitter of the detection system < 50 ps. Our setup demonstrates stable and efficient detection of the starlight owed to the large active area of the HPDs. Utilizing a new class of large area single photon detectors based on multichannel plate amplification, high resolution spatial intensity interferometry experiments are within reach at 1 m diameter class telescopes within one night of observation time for bright stars.
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- 2024
4. DanceCam: atmospheric turbulence mitigation in wide-field astronomical images with short-exposure video streams
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Bialek, Spencer, Bertin, Emmanuel, Fabbro, Sébastien, Bouy, Hervé, Rivet, Jean-Pierre, Lai, Olivier, and Cuillandre, Jean-Charles
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We introduce a novel technique to mitigate the adverse effects of atmospheric turbulence on astronomical imaging. Utilizing a video-to-image neural network trained on simulated data, our method processes a sliding sequence of short-exposure ($\sim$0.2s) stellar field images to reconstruct an image devoid of both turbulence and noise. We demonstrate the method with simulated and observed stellar fields, and show that the brief exposure sequence allows the network to accurately associate speckles to their originating stars and effectively disentangle light from adjacent sources across a range of seeing conditions, all while preserving flux to a lower signal-to-noise ratio than an average stack. This approach results in a marked improvement in angular resolution without compromising the astrometric stability of the final image., Comment: Accepted for publication in MNRAS (advance copy available at https://doi.org/10.1093/mnras/stae1018). Project website available at https://dancecam.info/ . 20 pages, 17 figures
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- 2024
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5. Pharmacologic Drug Detection and Self-Reported Adherence in the HPTN069/ACTG5305 Phase II PrEP Trial
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Cooper, Stanley E., Zhang, Shuaiqi, Haines, Daniel, Mayer, Kenneth H., Amico, K. Rivet, Landovitz, Raphael J., Hendrix, Craig W., Marzinke, Mark A., Chege, Wairimu, McCauley, Marybeth, and Gulick, Roy M.
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- 2024
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6. Syndemic Psychosocial Conditions among Youth Living with HIV: a Latent Class Analysis
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Wiginton, John Mark, Amico, K. Rivet, Hightow-Weidman, Lisa, Sullivan, Patrick, and Horvath, Keith J.
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- 2024
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7. Distributed Intelligent Integrated Sensing and Communications: The 6G-DISAC Approach
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Strinati, Emilio Calvanese, Alexandropoulos, George C., Giyyarpuram, Madhusudan, Sehier, Philippe, Mekki, Sami, Sciancalepore, Vincenzo, Stark, Maximilian, Sana, Mohamed, Denis, Benoit, Crozzoli, Maurizio, Amani, Navid, Mursia, Placido, Errico, Raffaele D, Boldi, Mauro, Costanzo, Francesca, Rivet, Francois, and Wymeerschx, Henk
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Electrical Engineering and Systems Science - Signal Processing ,Computer Science - Information Theory - Abstract
This paper introduces the concept of Distributed Intelligent integrated Sensing and Communications (DISAC), which expands the capabilities of Integrated Sensing and Communications (ISAC) towards distributed architectures. Additionally, the DISAC framework integrates novel waveform design with new semantic and goal-oriented communication paradigms, enabling ISAC technologies to transition from traditional data fusion to the semantic composition of diverse sensed and shared information. This progress facilitates large-scale, energy-efficient support for high-precision spatial-temporal processing, optimizing ISAC resource utilization, and enabling effective multi-modal sensing performance. Addressing key challenges such as efficient data management and connect-compute resource utilization, 6G- DISAC stands to revolutionize applications in diverse sectors including transportation, healthcare, and industrial automation. Our study encapsulates the project vision, methodologies, and potential impact, marking a significant stride towards a more connected and intelligent world., Comment: Submitted for conference publication
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- 2024
8. Towards Distributed and Intelligent Integrated Sensing and Communications for 6G Networks
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Strinati, Emilio Calvanese, Alexandropoulos, George C., Amani, Navid, Crozzoli, Maurizio, Madhusudan, Giyyarpuram, Mekki, Sami, Rivet, Francois, Sciancalepore, Vincenzo, Sehier, Philippe, Stark, Maximilian, and Wymeersch, Henk
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Electrical Engineering and Systems Science - Signal Processing ,Computer Science - Information Theory - Abstract
This paper introduces the distributed and intelligent integrated sensing and communications (DISAC) concept, a transformative approach for 6G wireless networks that extends the emerging concept of integrated sensing and communications (ISAC). DISAC addresses the limitations of the existing ISAC models and, to overcome them, it introduces two novel foundational functionalities for both sensing and communications: a distributed architecture and a semantic and goal-oriented framework. The distributed architecture enables large-scale and energy-efficient tracking of connected users and objects, leveraging the fusion of heterogeneous sensors. The semantic and goal-oriented intelligent and parsimonious framework, enables the transition from classical data fusion to the composition of semantically selected information, offering new paradigms for the optimization of resource utilization and exceptional multi-modal sensing performance across various use cases. This paper details DISAC's principles, architecture, and potential applications., Comment: Under review for possible publication in an IEEE Magazine
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- 2024
9. Walsh-domain Neural Network for Power Amplifier Behavioral Modelling and Digital Predistortion
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Thys, Cel, Alonso, Rodney Martinez, Lhomel, Antoine, Fellmann, Maxandre, Deltimple, Nathalie, Rivet, Francois, and Pollin, Sofie
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Electrical Engineering and Systems Science - Signal Processing - Abstract
This paper investigates the use of Neural Network (NN) nonlinear modelling for Power Amplifier (PA) linearization in the Walsh-Hadamard transceiver architecture. This novel architecture has recently been proposed for ultra-high bandwidth systems to reduce the transceiver power consumption by extensive parallelization of the digital baseband hardware. The parallelization is achieved by replacing two-dimensional quadrature modulation with multi-dimensional Walsh-Hadamard modulation. The open research question for this architecture is whether conventional baseband signal processing algorithms can be similarly parallelized while retaining their performance. A key baseband algorithm, digital predistortion using NN models for PA linearization, will be adapted to the parallel Walsh architecture. A straighforward parallelization of the state-of-the-art NN architecture is extended with a cross-domain Knowledge Distillation pre-training method to achieve linearization performance on par with the quadrature implementation. This result paves the way for the entire baseband processing chain to be adapted into ultra-high bandwidth, low-power Walsh transceivers., Comment: Accepted for presentation at the 2024 IEEE International Symposium on Circuits and Systems (ISCAS)
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- 2024
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10. Three-dimensional atmospheric dynamics of Jupiter from ground-based Doppler imaging spectroscopy in the visible
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Schmider, François-Xavier, Gaulme, Patrick, Morales-Juberías, Raúl, Jackiewicz, Jason, Gonçalves, Ivan, Guillot, Tristan, Simon, Amy A., Wong, Michael H., Underwood, Thomas, Voelz, David, Sanchez, Cristo, DeColibus, Riley, Kovac, Sarah A., Sellers, Sean, Gilliam, Doug, Boumier, Patrick, Appourchaux, Thierry, Dejonghe, Julien, Rivet, Jean Pierre, Markham, Steve, Howard, Saburo, Abe, Lyu, Mekarnia, Djamel, Ikoma, Masahiro, Hanayama, Hidekazu, Sato, Bun'ei, Kunitomo, Masanobu, and Izumiura, Hideyuki
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present three-dimensional (3D) maps of Jupiter's atmospheric circulation at cloud-top level from Doppler-imaging data obtained in the visible domain with JIVE, the second node of the JOVIAL network, which is mounted on the Dunn Solar Telescope at Sunspot, New Mexico. We report on 12 nights of observations between May 4 and May 30, 2018, representing a total of about 80 hours. Firstly, the average zonal wind profile derived from our data is compatible with that derived from cloud-tracking measurements performed on Hubble Space Telescope images obtained in April 2018 from the Outer Planet Atmospheres Legacy (OPAL) program. Secondly, we present the first ever two-dimensional maps of Jupiter's atmospheric circulation from Doppler measurements. The zonal velocity map highlights well-known atmospheric features, such as the equatorial hot spots and the Great Red Spot (GRS). In addition to zonal winds, we derive meridional and vertical velocity fields from the Doppler data. The motions attributed to vertical flows are mainly located at the boundary between the equatorial belts and tropical zones, which could indicate active motion in theses regions. Qualitatively, these results compare well to recent Juno data that have unveiled the three-dimensional structure of Jupiter's wind field. To the contrary, the motions attributed to meridional circulation are very different from what is obtained by cloud tracking, except at the GRS. Because of limitations with data resolution and processing techniques, we acknowledge that our measurement of vertical or meridional flows of Jupiter are still to be confirmed.
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- 2023
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11. The Milky Way Bulge extra-tidal star survey: BH 261 (AL 3)
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Kunder, Andrea, Prudil, Zdenek, Covey, Kevin, Hughes, Joanne, Joyce, Meridith, Simion, Iulia T., Kuss, Rebekah, Campos, Carlos, Johnson, Christian I., Pilachowski, Catherine A., Larson, Kristen A., Koch-Hansen, Andreas J., Marchetti, Tommaso, Rich, Michael R., Butler, Evan, Clarkson, William I., Rivet, Michael J., Devine, Kathryn, Vivas, A. Katherina, Perren, Gabriel I., Soto, Mario, and Silva, Erika
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The Milky Way Bulge extra-tidal star survey (MWBest) is a spectroscopic survey with the goal of identifying stripped globular cluster stars from inner Galaxy clusters. In this way, an indication of the fraction of metal-poor bulge stars that originated from globular clusters can be determined. We observed and analyzed stars in and around BH 261, an understudied globular cluster in the bulge. From seven giants within the tidal radius of the cluster, we measured an average heliocentric radial velocity of
= -61 +- 2.6 km/s with a radial velocity dispersion of \sigma = 6.1 +- 1.9 km/s. The large velocity dispersion may have arisen from tidal heating in the cluster's orbit about the Galactic center, or because BH 261 has a high dynamical mass as well as a high mass-to-light ratio. From spectra of five giants, we measure an average metallicity of <[Fe/H]> = -1.1 +- 0.2 dex. We also spectroscopically confirm an RR Lyrae star in BH 261, which yields a distance to the cluster of 7.1 +- 0.4~kpc. Stars with 3D velocities and metallicities consistent with BH 261 reaching to ~0.5 degrees from the cluster are identified. A handful of these stars are also consistent with the spatial distribution of that potential debris from models focussing on the most recent disruption of the cluster., Comment: accepted for publication in The Astronomical Journal - Published
- 2023
12. Ready for O4 II: GRANDMA Observations of Swift GRBs during eight-weeks of Spring 2022
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Melo, I. Tosta e, Ducoin, J. -G., Vidadi, Z., Andrade, C., Rupchandani, V., Agayeva, S., Abdelhadi, J., Abe, L., Aguerre-Chariol, O., Aivazyan, V., Alishov, S., Antier, S., Bai, J. -M., Baransky, A., Bednarz, S., Bendjoya, Ph., Benkhaldoun, Z., Beradze, S., Bizouard, M. A., Bhardwaj, U., Blazek, M., Boër, M., Broens, E., Burkhonov, O., Christensen, N., Cooke, J., Corradi, W., Coughlin, M. W., Culino, T., Daigne, F., Dornic, D., Duverne, P. -A., Ehgamberdiev, S., Eymar, L., Fouad, A., Freeberg, M., Gendre, B., Guo, F., Gokuldass, P., Guessoum, N., Gurbanov, E., Hainich, R., Hasanov, E., Hello, P., Inasaridze, R., Iskandar, A., Ismailov, N., Janati, A., Laz, T. Jegou du, Kann, D. A., Karpov, S., Kiendrebeogo, R. W., Klotz, A., Kneip, R., Kochiashvili, N., Kaeouach, A., Kruiswijk, K., Lamoureux, M., Leroy, N., Lin, W. L., Mao, J., Marchais, D., Mašek, M., Midavaine, T., Moller, A., Morris, D., Natsvlishvili, R., Navarete, F., Guelbenzu, A Nicuesa, Noonan, K., Noysena, K., Oksanen, A., Orange, N. B., Pellouin, C., Peloton, J., Peng, H. W., Pilloix, M., Popowicz, A., Pradier, T., Pyshna, O., Raaijmakers, G., Rajabov, Y., Rau, A., Rinner, C., Rivet, J. -P., Ryh, A. S., Sabil, M., Sadibekova, T., Sasaki, N., Serrau, M., Simon, A., Shokry, A., Smith, K., Sokoliuk, O., Song, X., Takey, A., Thierry, P., Tillayev, Y., Turpin, D., Postigo, A. de Ugarte, Vasylenko, V., Vernet, D., Wang, L., Vachier, F., Vignes, J. P., Wang, X. F., Zeng, X., Zhang, J., and Zhu, Y.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present a campaign designed to train the GRANDMA network and its infrastructure to follow up on transient alerts and detect their early afterglows. In preparation for O4 II campaign, we focused on GRB alerts as they are expected to be an electromagnetic counterpart of gravitational-wave events. Our goal was to improve our response to the alerts and start prompt observations as soon as possible to better prepare the GRANDMA network for the fourth observational run of LIGO-Virgo-Kagra (which started at the end of May 2023), and future missions such as SM. To receive, manage and send out observational plans to our partner telescopes we set up dedicated infrastructure and a rota of follow-up adcates were organized to guarantee round-the-clock assistance to our telescope teams. To ensure a great number of observations, we focused on Swift GRBs whose localization errors were generally smaller than the GRANDMA telescopes' field of view. This allowed us to bypass the transient identification process and focus on the reaction time and efficiency of the network. During 'Ready for O4 II', 11 Swift/INTEGRAL GRB triggers were selected, nine fields had been observed, and three afterglows were detected (GRB 220403B, GRB 220427A, GRB 220514A), with 17 GRANDMA telescopes and 17 amateur astronomers from the citizen science project Kilonova-Catcher. Here we highlight the GRB 220427A analysis where our long-term follow-up of the host galaxy allowed us to obtain a photometric redshift of $z=0.82\pm0.09$, its lightcurve elution, fit the decay slope of the afterglows, and study the properties of the host galaxy.
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- 2023
13. Multi-band analyses of the bright GRB 230812B and the associated SN2023pel
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Hussenot-Desenonges, T., Wouters, T., Guessoum, N., Abdi, I., Abulwfa, A., Adami, C., Fernández, J. F. Agüí, Ahumada, T., Aivazyan, V., Akl, D., Anand, S., Andrade, C. M., Antier, S., Ata, S. A., D'Avanzo, P., Azzam, Y. A., Baransky, A., Basa, S., Blazek, M., Bendjoya, P., Beradze, S., Boumis, P., Bremer, M., Brivio, R., Buat, V., Bulla, M., Burkhonov, O., Burns, E., Cenko, S. B., Corradi, W., Coughlin, M. W., Daigne, F., Dietrich, T., Dornic, D., Ducoin, J. -G., Duverne, P. -A., Elhosseiny, E. G., Elnagahy, F. I., El-Sadek, M. A., Ferro, M., Floc'h, E. Le, Freeberg, M., Fynbo, J. P. U., Götz, D., Gurbanov, E., Hamed, G. M., Hasanov, E., Healy, B. F., Heintz, K. E., Hello, P., Inasaridze, R., Iskandar, A., Ismailov, N., Izzo, L., Jhawar, S., Laz, T. Jegou du, Kamel, T. M., Karpov, S., Klotz, A., Koulouridis, E., Kuin, N. P., Kochiashvili, N., Leonini, S., Lu, K. -X., Malesani, D. B., Masek, M., Mao, J., Melandri, A., Mihov, B. M., Natsvlishvili, R., Navarete, F., Nedora, V., Nicolas, J., Odeh, M., Palmerio, J., Pang, P. T. H., De Pasquale, M., Peng, H. W., Pormente, S., Peloton, J., Pradier, T., Pyshna, O., Rajabov, Y., Rakotondrainibe, N. A., Rivet, J. -P., Rousselot, L., Saccardi, A., Sasaki, N., Schneider, B., Serrau, M., Shokry, A., Slavcheva-Mihova, L., Simon, A., Sokoliuk, O., Srinivasaragavan, G., Strausbaugh, R., Tanvir, N. R., Takey, A., Thöne, C. C., Tillayev, Y., Melo, I. Tosta e, Turpin, D., Postigo, A. de Ugarte, Vasylenko, V., Vergani, S. D., Vidadi, Z., Xu, D., Wang, L. T., Wang, X. F., Winters, J. M., Zhang, X -L., and Zhu, Z.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
GRB~230812B is a bright and relatively nearby ($z =0.36$) long gamma-ray burst (GRB) that has generated significant interest in the community and has thus been observed over the entire electromagnetic spectrum. We report over 80 observations in X-ray, ultraviolet, optical, infrared, and sub-millimeter bands from the GRANDMA (Global Rapid Advanced Network for Multi-messenger Addicts) network of observatories and from observational partners. Adding complementary data from the literature, we then derive essential physical parameters associated with the ejecta and external properties (i.e. the geometry and environment) of the GRB and compare with other analyses of this event. We spectroscopically confirm the presence of an associated supernova, SN2023pel, and we derive a photospheric expansion velocity of v $\sim$ 17$\times10^3$ km s$^{-1}$. We analyze the photometric data first using empirical fits of the flux and then with full Bayesian Inference. We again strongly establish the presence of a supernova in the data, with a maximum (pseudo-)bolometric luminosity of $5.75 \times 10^{42}$ erg/s, at $15.76^{+0.81}_{-1.21}$ days (in the observer frame) after the trigger, with a half-max time width of 22.0 days. We compare these values with those of SN1998bw, SN2006aj, and SN2013dx. Our best-fit model favours a very low density environment ($\log_{10}({n_{\rm ISM}/{\rm cm}^{-3}}) = -2.38^{+1.45}_{-1.60}$) and small values for the jet's core angle $\theta_{\rm core} = 1.54^{+1.02}_{-0.81} \ \rm{deg}$ and viewing angle $\theta_{\rm obs} = 0.76^{+1.29}_{-0.76} \ \rm{deg}$. GRB 230812B is thus one of the best observed afterglows with a distinctive supernova bump.
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- 2023
14. V(WF)$^2$S: Very Wide Field WaveFront Sensor for GLAO
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Lai, Olivier, Chun, Mark, Kuiper, Stefan, Doelman, Niek, Carbillet, Marcel, N'Diaye, Mamadou, Martinache, Frantz, Abe, Lyu, Rivet, Jean-Pierre, and Schmidt, Dirk
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Adaptive optics is a technique mostly used on large telescopes. It turns out to be challenging for smaller telescopes (0.5~2m) due to the small isoplanatic angle, small subapertures and high correction speeds needed at visible wavelengths, requiring bright stars for guiding, severely limiting the sky coverage. NGS SCAO is ideal for planetary objects but remains limited for general purpose observing. The approach we consider is a compromise between image quality gain and sky coverage: we propose to partially improve the image quality anywhere in the sky instead of providing the diffraction limit around a few thousand bright stars. We suggest a new solution based on multiple AO concepts brought together: The principle is based on a rotating Foucault test, like the first AO concept proposed by H. Babcock in 1953, on the Ground Layer Adaptive Optics, proposed by Rigaut and Tokovinin in the early 2000s, and on the idea of Layer-oriented MCAO and the pupil-plane wavefront analysis by R. Ragazzoni. We propose to combine these techniques to use all the light available in a large field to measure the ground layer turbulence and enable the high angular resolution imaging of regions of the sky (e.g., nebulas, galaxies) inaccessible to traditional AO systems. The motivation to develop compact and robust AO system for small telescopes is two-fold: On the one hand, universities often have access to small telescopes as part of their education programs. Also, researchers in countries with fewer resources could also benefit from reliable adaptive optics system on smaller telescopes for research and education purposes. On the other hand, amateur astronomers and enthusiasts want improved image quality for visual observation and astrophotography. Implementing readily accessible adaptive optics in astronomy clubs would also likely have a significant impact on citizen science., Comment: 9 pages, 9 figures, Conference Proceeding AO4ELT7
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- 2023
15. The impact of intimate partner violence on PrEP adherence among U.S. Cisgender women at risk for HIV
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Anderson, Katherine M, Blumenthal, Jill, Jain, Sonia, Sun, Xiaoying, Amico, K Rivet, Landovitz, Raphael, Zachek, Christine M, Morris, Sheldon, Moore, David J, and Stockman, Jamila K
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Epidemiology ,Health Services and Systems ,Public Health ,Health Sciences ,Infectious Diseases ,Prevention ,HIV/AIDS ,Behavioral and Social Science ,Violence Against Women ,Violence Research ,Clinical Research ,Mental Health ,Women's Health ,Sexually Transmitted Infections ,Gender Equality ,Peace ,Justice and Strong Institutions ,Good Health and Well Being ,Adolescent ,Adult ,Female ,Humans ,Middle Aged ,Young Adult ,Anti-HIV Agents ,California ,HIV Infections ,Intimate Partner Violence ,Medication Adherence ,Pre-Exposure Prophylaxis ,Tenofovir ,United States ,Intimate Partner violence ,Pre-exposure Prophylaxis for HIV Prevention ,Adherence ,Violence ,Public Health and Health Services ,Health services and systems ,Public health - Abstract
BackgroundCisgender women account for 1 in 5 new HIV infections in the United States, yet remain under-engaged in HIV prevention. Women experiencing violence face risk for HIV due to biological and behavioral mechanisms, and barriers to prevention, such as challenges to Pre-Exposure Prophylaxis for HIV Prevention (PrEP) adherence. In this analysis, we aim to characterize intimate partner violence (IPV) among cisgender heterosexual women enrolled in a PrEP demonstration project and assess the associations with PrEP adherence.MethodsAdherence Enhancement Guided by Individualized Texting and Drug Levels (AEGiS) was a 48-week single-arm open-label study of PrEP adherence in HIV-negative cisgender women in Southern California (N = 130) offered daily tenofovir disoproxil fumarate/emtricitabine (TDF/FTC). From 6/2016 to 10/2018, women completed a survey reporting HIV risk behavior and experiences of any IPV (past 90-days) and IPV sub-types (past-year, lifetime) and biological testing for HIV/STIs at baseline, and concentrations of tenofovir-diphosphate (TFV-DP) in dried blood spots at weeks 4, 12, 24, 36, and 48. Outcomes were TFV-DP concentrations consistent with ≥ 4 or ≥ 6 doses/week at one or multiple visits. Multivariable logistic regression models were conducted to examine associations.ResultsPast-90-day IPV was reported by 34.4% of participants, and past-year and lifetime subtypes reported by 11.5-41.5%, and 21.5-52.3%, respectively. Women who engaged in sex work and Black women were significantly more likely to report IPV than others. Lifetime physical IPV was negatively associated with adherence at ≥ 4 doses/week at ≥ 3 of 5 visits, while other relationships with any IPV and IPV sub-types were variable.ConclusionIPV is an indication for PrEP and important indicator of HIV risk; our findings suggest that physical IPV may also negatively impact long-term PrEP adherence.Clinical trials registrationNCT02584140 (ClinicalTrials.gov), registered 15/10/2015.
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- 2024
16. A conceptual health state diagram for modelling the transmission of a (re)emerging infectious respiratory disease in a human population
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Avramov, Marc, Gabriele-Rivet, Vanessa, Milwid, Rachael M., Ng, Victoria, Ogden, Nicholas H., and Hongoh, Valerie
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- 2024
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17. Incarceration history and opioid use among adults living with HIV and chronic pain: a secondary analysis of a prospective cohort study
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Lichtiger, Anna B., Deng, Yuting, Zhang, Chenshu, Groeger, Justina, Perez, Hector R., Nangia, Gayatri, Prinz, Melanie, Richard, Emma, Glenn, Matthew, De La Cruz, Ana Alicia, Pazmino, Ariana, Cunningham, Chinazo O., Amico, K Rivet, Fox, Aaron, and Starrels, Joanna L.
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- 2024
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18. A methodology for estimating SARS-CoV-2 importation risk by air travel into Canada between July and November 2021
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Milwid, Rachael M., Gabriele-Rivet, Vanessa, Ogden, Nicholas H., Turgeon, Patricia, Fazil, Aamir, London, David, de Montigny, Simon, and Rees, Erin E.
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- 2024
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19. A conceptual health state diagram for modelling the transmission of a (re)emerging infectious respiratory disease in a human population
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Marc Avramov, Vanessa Gabriele-Rivet, Rachael M. Milwid, Victoria Ng, Nicholas H. Ogden, and Valerie Hongoh
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Mathematical modelling ,Emerging disease ,Reemerging disease ,Pandemic ,Epidemic ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Mathematical modelling of (re)emerging infectious respiratory diseases among humans poses multiple challenges for modellers, which can arise as a result of limited data and surveillance, uncertainty in the natural history of the disease, as well as public health and individual responses to outbreaks. Here, we propose a COVID-19-inspired health state diagram (HSD) to serve as a foundational framework for conceptualising the modelling process for (re)emerging respiratory diseases, and public health responses, in the early stages of their emergence. The HSD aims to serve as a starting point for reflection on the structure and parameterisation of a transmission model to assess the impact of the (re)emerging disease and the capacity of public health interventions to control transmission. We also explore the adaptability of the HSD to different (re)emerging diseases using the characteristics of three respiratory diseases of historical public health importance. We outline key questions to contemplate when applying and adapting this HSD to (re)emerging infectious diseases and provide reflections on adapting the framework for public health-related interventions.
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- 2024
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20. Close-to-fission dumbbell Jupiter-Trojan (17365) Thymbraeus
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Carry, B., Descamps, P., Ferrais, M., Rivet, J. -P., Berthier, J., Jehin, E., Vernet, D., Abe, L., Bendjoya, P., Vachier, F., Pajuelo, M., Birlan, M., Colas, F., and Benkhaldoun, Z.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Every population of small bodies in the Solar system contains a sizable fraction of multiple systems. Among these, the Jupiter Trojans have the lowest number of known binary systems and the least characterized. We aim at characterizing the reported binary system (17365) Thymbraeus, one of the only seven multiple systems known among Jupiter Trojans. We conducted light curves observing campaigns in 2013, 2015, and 2021 with ground-based telescopes. We model these lightcurves using dumbbell equilibrium figures. We show that Thymbraeus is unlikely a binary system. Its light curves are fully consistent with a bilobated shape: a dumbbell equilibrium figure. We determine a low density of 830 +/- 50 kg.m-3 , consistent with the reported density of other Jupiter Trojan asteroids and small Kuiper-belt objects. The angular velocity of Thymbraeus is close to fission. If separated, its components would become a similarly-sized double asteroid such as the other Jupiter Trojan (617) Patroclus., Comment: accepted for publication in A&A
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- 2023
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21. Speckle observations of the binary asteroid (22) Kalliope with C2PU/PISCO
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Aristidi, E., Carry, B., Minker, K., Prieur, J. -L., Scardia, M., Rivet, J. -P., Bendjoya, P., Abe, L., Argyle, R. -W., Koechlin, L., Ling, J. F., Maccarini, L., Pansecchi, L., Piccotti, L., Serot, J., and Vernet, D.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present new speckle measurements of the position of Linus, the satellite of the asteroid (22) Kalliope, obtained at the 1m C2PU-Epsilon telescope on the Plateau de Calern, France. Observations were made in the visible domain with the speckle camera PISCO. We obtained 122 measurements in February-March 2022 and April 2023, with a mean uncertainty close to 10 milli-arcseconds on the angular separation.
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- 2023
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22. Mechanics of human embryo compaction
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Firmin, Julie, Ecker, Nicolas, Rivet Danon, Diane, Özgüç, Özge, Barraud Lange, Virginie, Turlier, Hervé, Patrat, Catherine, and Maître, Jean-Léon
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- 2024
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23. GRANDMA and HXMT Observations of GRB 221009A -- the Standard-Luminosity Afterglow of a Hyper-Luminous Gamma-Ray Burst
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Kann, D. A., Agayeva, S., Aivazyan, V., Alishov, S., Andrade, C. M., Antier, S., Baransky, A., Bendjoya, P., Benkhaldoun, Z., Beradze, S., Berezin, D., Boër, M., Broens, E., Brunier, S., Bulla, M., Burkhonov, O., Burns, E., Chen, Y., Chen, Y. P., Conti, M., Coughlin, M. W., Cui, W. W., Daigne, F., Delaveau, B., Devillepoix, H. A. R., Dietrich, T., Dornic, D., Dubois, F., Ducoin, J. -G., Durand, E., Duverne, P. -A., Eggenstein, H. -B., Ehgamberdiev, S., Fouad, A., Freeberg, M., Froebrich, D., Ge, M. Y., Gervasoni, S., Godunova, V., Gokuldass, P., Gurbanov, E., Han, D. W., Hasanov, E., Hello, P., Hussenot-Desenonges, T., Inasaridze, R., Iskandar, A., Ismailov, N., Janati, A., Laz, T. Jegou du, Jia, S. M., Karpov, S., Kaeouach, A., Kiendrebeogo, R. W., Klotz, A., Kneip, R., Kochiashvili, N., Kunert, N., Lekic, A., Leonini, S., Li, C. K., Li, W., Li, X. B., Liao, J. Y., Logie, L., Lu, F. J., Mao, J., Marchais, D., Ménard, R., Morris, D., Natsvlishvili, R., Nedora, V., Noonan, K., Noysena, K., Orange, N. B., Pang, P. T. H., Peng, H. W., Pellouin, C., Peloton, J., Pradier, T., Pyshna, O., Rajabo, Y., Rau, S., Rinner, C., Rivet, J. -P., Romanov, F. D., Rosi, P., Rupchandani, V. A., Serrau, M., Shokry, A., Simon, A., Smith, K., Sokoliuk, O., Soliman, M., Song, L. M., Takey, A., Tillayev, Y., Ramirez, L. M. Tinjaca, Melo, I. Tosta e, Turpin, D., Postigo, A. de Ugarte, Vanaverbeke, S., Vasylenko, V., Vernet, D., Vidadi, Z., Wang, C., Wang, J., Wang, L. T., Wang, X. F., Xiong, Shaolin L., Xu, Y. P., Xue, W. C., Zeng, X., Zhang, S. N., Zhao, H. S., and Zhao, X. F.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
GRB 221009A is the brightest Gamma-Ray Burst (GRB) detected in more than 50 years of study. In this paper, we present observations in the X-ray and optical domains after the GRB obtained by the GRANDMA Collaboration (which includes observations from more than 30 professional and amateur telescopes) and the Insight-HXMT Collaboration. We study the optical afterglow with empirical fitting from GRANDMA+HXMT data, augmented with data from the literature up to 60 days. We then model numerically, using a Bayesian approach, the GRANDMA and HXMT-LE afterglow observations, that we augment with Swift-XRT and additional optical/NIR observations reported in the literature. We find that the GRB afterglow, extinguished by a large dust column, is most likely behind a combination of a large Milky-Way dust column combined with moderate low-metallicity dust in the host galaxy. Using the GRANDMA+HXMT-LE+XRT dataset, we find that the simplest model, where the observed afterglow is produced by synchrotron radiation at the forward external shock during the deceleration of a top-hat relativistic jet by a uniform medium, fits the multi-wavelength observations only moderately well, with a tension between the observed temporal and spectral evolution. This tension is confirmed when using the extended dataset. We find that the consideration of a jet structure (Gaussian or power-law), the inclusion of synchrotron self-Compton emission, or the presence of an underlying supernova do not improve the predictions, showing that the modelling of GRB22109A will require going beyond the most standard GRB afterglow model. Placed in the global context of GRB optical afterglows, we find the afterglow of GRB 221009A is luminous but not extraordinarily so, highlighting that some aspects of this GRB do not deviate from the global known sample despite its extreme energetics and the peculiar afterglow evolution., Comment: Accepted to ApJL for the special issue, 37 pages, 23 pages main text, 6 tables, 13 figures
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- 2023
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24. Intensity Interferometry observations of the H$\alpha$ envelope of $\gamma$ Cas with M\'{e}O and a portable telescope
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Matthews, Nolan, Rivet, Jean-Pierre, Vernet, David, Hugbart, Mathilde, Labeyrie, Guillaume, Kaiser, Robin, Chabé, Julien, Courde, Clément, Lai, Olivier, Vakili, Farrokh, Garde, Olivier, and Guerin, William
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We report on observations of the extended environment of the bright Be star $\gamma$-Cas performed using intensity interferometry measurements within its H$\alpha$ emission line. These observations were performed using a modified version of the I2C intensity interferometry instrument installed onto the 1.54 meter M\'{e}O optical metrology telescope and a portable 1-meter telescope (T1M). In order to better constrain the extent of the H$\alpha$ envelope, observations were performed for two different positions of the T1M telescope, corresponding to an intermediate and long baselines in which the extended region was partially and fully resolved. We find that the observed data are consistent with past interferometric observations of $\gamma$-Cas. These observations demonstrate the capability to equip optical telescopes of different optical designs with intensity interferometry capabilities and illustrate the potential to scale a similar system onto many additional telescopes.
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- 2023
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25. Does transport affect the eating quality potential of beef from Limousin cows in France? - A case study
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Nathalia da Silva Rodrigues Mendes, Renato Rodrigues Silva, Moïse Kombolo-Ngah, Pierre-Philippe Rivet, Jerôme Tondusson, Tatianne Ferreira de Oliveira, Sghaier Chriki, Marie-Pierre Ellies-Oury, and Jean-François Hocquette
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Pre-slaughter stress ,Animal welfare ,Beef eating quality ,MSA ,Carcass traits ,Veterinary medicine ,SF600-1100 - Abstract
We hypothesized that transportation might impact beef sensory quality, particularly as the distance between farms and the slaughterhouse increases. Specifically, we expected that pre-slaughter transport over longer distances would induce stress in the cattle, resulting in elevated ultimate pH and, consequently, reduced beef quality. Thus, this study aimed to specifically study the effects of transport in commercial conditions of Limousin cows from farms located in different areas of France to slaughter on ultimate pH (pHu) measured in the Longissimus thoracis muscle (LT), marbling (two major factors affecting eating quality) and the MSA Index (a global indicator of potential eating quality at the carcass level). Cattle were studied according to distance (
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- 2024
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26. Efficacy and safety of three antiretroviral therapy regimens started in pregnancy up to 50 weeks post partum: a multicentre, open-label, randomised, controlled, phase 3 trial
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Chinula, Lameck, Ziemba, Lauren, Brummel, Sean, McCarthy, Katie, Coletti, Anne, Krotje, Chelsea, Johnston, Benjamin, Knowles, Kevin, Moyo, Sikhulile, Stranix-Chibanda, Lynda, Hoffman, Risa, Sax, Paul E, Stringer, Jeffrey, Chakhtoura, Nahida, Jean-Philippe, Patrick, Korutaro, Violet, Cassim, Haseena, Fairlie, Lee, Masheto, Gaerolwe, Boyce, Ceejay, Frenkel, Lisa M, Amico, K Rivet, Purdue, Lynette, Shapiro, Roger, Mmbaga, Blandina Theophil, Patel, Faeezah, van Wyk, Jean, Rooney, James F, Currier, Judith S, Lockman, Shahin, Best, Brookie M, Blanchette, Cheryl D, Browning, Renee, Jaliaah, Nagawa, Mirochnick, Mark, Murtaugh, William A, Patras, Emmanuel, Whalen, Frances, Momper, Jeremiah D, Ponatshego, Ponego L, Tirelo, Lesedi, Seme, Boitshepo J, Modise, Georginah O, Raesi, Mpho S, Budu, Marian E, Ramogodiri, Moakanyi, Oliveira, Ricardo H, Hofe, Cristina B, de Abreu, Thalita Fernandes, Pestanha, Lorena M, João, Esaú, Sidi, Leon C, Fuller, Trevon, Cruz, Maria LS, Pinto, Jorge, Ferreira, Flãvia, Correa, Mãrio, Romeiro, Juliana, Pilotto, Jose H, Fernandes, Luis EBC, Moreira, Luiz F, Gomes, Ivete M, Naik, Shilpa, Nevrekar, Neetal, Mave, Vidya, Kinikar, Aarti, Horne, Elizea, Soma-Kasiram, Hamisha, Violari, Avy, Mathiba, Sisinyana R, Nyati, Mandisa, Theron, Gerhard, de Jager, Jeanne, Rossouw, Magdel, Rossouw, Lindie, Hanley, Sherika, Desmond, Alicia C, Gazu, Rosemary, Govender, Vani, Chalermchockcharoenkit, Amphan, Thamkhantho, Manopchai, Werarak, Peerawong, Rungmaitree, Supattra, Achalapong, Jullapong, Sitiritkawin, Lukkana, Cressey, Tim R, Sukrakanchana, Pra-ornsuda, Aurpibul, Linda, Tongprasert, Fuanglada, Khamrong, Chintana, Kiattivej, Sopida, Wabwire, Deo, Kabugo, Enid, Maena, Joel, Nakayiwa, Frances, Ndyanabangi, Victoria, Nagaddya, Beatrice, Sekabira, Rogers, Ashaba, Justus, and Mitchell, Charles D
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Mental Health ,Infectious Diseases ,Pediatric ,HIV/AIDS ,Clinical Research ,Clinical Trials and Supportive Activities ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Reproductive health and childbirth ,Infection ,Good Health and Well Being ,Pregnancy ,Child ,Female ,Humans ,Male ,HIV Infections ,Anti-HIV Agents ,Tenofovir ,Benzoxazines ,Emtricitabine ,Adenine ,RNA ,Viral Load ,IMPAACT 2010/VESTED Study Team and Investigators ,Medical and Health Sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundDrugs taken during pregnancy can affect maternal and child health outcomes, but few studies have compared the safety and virological efficacy of different antiretroviral therapy (ART) regimens. We report the primary safety outcomes from enrolment up to 50 weeks post partum and a secondary virological efficacy outcome at 50 weeks post partum of three commonly used ART regimens for HIV-1.MethodsIn this multicentre, open-label, randomised, controlled, phase 3 trial, we enrolled pregnant women aged 18 years or older with confirmed HIV-1 infection at 14-28 weeks of gestation. Women were enrolled at 22 clinical research sites in nine countries (Botswana, Brazil, India, South Africa, Tanzania, Thailand, Uganda, the USA, and Zimbabwe). Participants were randomly assigned (1:1:1) to one of three oral regimens: dolutegravir, emtricitabine, and tenofovir alafenamide; dolutegravir, emtricitabine, and tenofovir disoproxil fumarate; or efavirenz, emtricitabine, and tenofovir disoproxil fumarate. Up to 14 days of antepartum ART before enrolment was permitted. Women with known multiple gestation, fetal anomalies, acute significant illness, transaminases more than 2·5 times the upper limit of normal, or estimated creatinine clearance of less than 60 mL/min were excluded. Primary safety analyses were pairwise comparisons between ART regimens of the proportion of maternal and infant adverse events of grade 3 or higher up to 50 weeks post partum. Secondary efficacy analyses at 50 weeks post partum included a comparison of the proportion of women with plasma HIV-1 RNA of less than 200 copies per mL in the combined dolutegravir-containing groups versus the efavirenz-containing group. Analyses were done in the intention-to-treat population, which included all randomly assigned participants with available data. This trial was registered with ClinicalTrials.gov, NCT03048422.FindingsBetween Jan 19, 2018, and Feb 8, 2019, we randomly assigned 643 pregnant women to the dolutegravir, emtricitabine, and tenofovir alafenamide group (n=217), the dolutegravir, emtricitabine, and tenofovir disoproxil fumarate group (n=215), and the efavirenz, emtricitabine, and tenofovir disoproxil fumarate group (n=211). At enrolment, median gestational age was 21·9 weeks (IQR 18·3-25·3), median CD4 count was 466 cells per μL (308-624), and median HIV-1 RNA was 903 copies per mL (152-5183). 607 (94%) women and 566 (92%) of 617 liveborn infants completed the study. Up to the week 50 post-partum visit, the estimated probability of experiencing an adverse event of grade 3 or higher was 25% in the dolutegravir, emtricitabine, and tenofovir alafenamide group; 31% in the dolutegravir, emtricitabine, and tenofovir disoproxil fumarate group; and 28% in the efavirenz, emtricitabine, and tenofovir disoproxil fumarate group (no significant difference between groups). Among infants, the estimated probability of experiencing at least one adverse event of grade 3 or higher by postnatal week 50 was 28% overall, with small and non-statistically significant differences between groups. By postnatal week 50, 14 infants whose mothers were in the efavirenz-containing group (7%) died, compared with six in the combined dolutegravir groups (1%). 573 (89%) women had HIV-1 RNA data available at 50 weeks post partum: 366 (96%) in the dolutegravir-containing groups and 186 (96%) in the efavirenz-containing group had HIV-1 RNA less than 200 copies per mL, with no significant difference between groups.InterpretationSafety and efficacy data during pregnancy and up to 50 weeks post partum support the current recommendation of dolutegravir-based ART (particularly in combination with emtricitabine and tenofovir alafenamide) rather than efavirenz, emtricitabine, and tenofovir disoproxil fumarate, when started in pregnancy.FundingNational Institute of Allergy and Infectious Diseases, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, and the National Institute of Mental Health.
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- 2023
27. Adolescents Living With or at Risk for HIV: A Pooled Descriptive Analysis of Studies From the Adolescent Medicine Trials Network for HIV/AIDS Interventions
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DeMonte, Justin, McCumber, Micah, Slye, Nicole, Amico, K Rivet, Arnold, Elizabeth M, Comulada, W Scott, Hayati Rezvan, Panteha, Hightow-Weidman, Lisa B, Muessig, Kathryn E, Nichols, Sharon L, Nielsen-Saines, Karin, Sanchez, Travis H, Shook-Sa, Bonnie E, Swendeman, Dallas, Valencia, Rachel K, and Hudgens, Michael G
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Paediatrics ,Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Infectious Diseases ,Sexually Transmitted Infections ,HIV/AIDS ,Adolescent Sexual Activity ,Pediatric ,Prevention ,Pediatric AIDS ,Social Determinants of Health ,Behavioral and Social Science ,Clinical Research ,Good Health and Well Being ,Adolescent ,Humans ,Acquired Immunodeficiency Syndrome ,Adolescent Medicine ,HIV Infections ,Surveys and Questionnaires ,United States ,Young Adult ,White ,Black or African American ,Hispanic or Latino ,Adolescent medicine trials network for HIV ,AIDS interventions ,Data harmonization ,HIV ,Youth ,Gay ,Bisexual ,Transgender ,Adolescent medicine trials network for HIV/AIDS interventions ,Medical and Health Sciences ,Education ,Psychology and Cognitive Sciences ,Biomedical and clinical sciences ,Health sciences ,Psychology - Abstract
PurposeThis study aims to describe the cohort of Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) research program participants and evaluate whether the ATN's recently completed 5-year cycle recruited study participants who parallel the populations most impacted by HIV in the United States.MethodsHarmonized measures across ATN studies collected at baseline were aggregated for participants aged 13-24 years. Pooled means and proportions stratified by HIV status (at risk for or living with HIV) were calculated using unweighted averages of study-specific aggregate data. Medians were estimated using a weighted median of medians method. Public use 2019 Centers for Disease Control and Prevention surveillance data for state-level new HIV diagnoses and HIV prevalence among US youth aged 13-24 years were obtained for use as reference populations for ATN at-risk youth and youth living with HIV (YLWH), respectively.ResultsData from 3,185 youth at-risk for HIV and 542 YLWH were pooled from 21 ATN study phases conducted across the United States. Among ATN studies tailored to at-risk youth, a higher proportion of participants were White and a lower proportion were Black/African American and Hispanic/Latinx compared to youth newly diagnosed with HIV in the United States in 2019. Participants in ATN studies tailored to YLWH were demographically similar to YLWH in the United States.DiscussionThe development of data harmonization guidelines for ATN research activities facilitated this cross-network pooled analysis. These findings suggest the ATN's YLWH are representative, but that future studies of at-risk youth should prioritize recruitment strategies to enroll more participants from African American and Hispanic/Latinx populations.
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- 2023
28. Asteroid spin-states of a 4 Gyr collisional family
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Athanasopoulos, D., Hanus, J., Avdellidou, C., Bonamico, R., Delbo, M., Conjat, M., Ferrero, A., Gazeas, K., Rivet, J. P., Sioulas, N., van Belle, G., Antonini, P., Audejean, M., Behrend, R., Bernasconi, L., Brinsfield, J. W., Brouillard, S., Brunetto, L., Fauvaud, M., Fauvaud, S., González, R., Higgins, D., Holoien, T. W. -S., Kobber, G., Koff, R. A., Kryszczynska, A., Livet, F., Marciniak, A., Oey, J., Pejcha, O., Rives, J. J., and Roy, R.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Families of asteroids generated by the collisional fragmentation of a common parent body have been identified using clustering methods of asteroids in their proper orbital element space. An alternative method has been developed in order to identify collisional families from the correlation between the asteroid fragment sizes and their proper semi-major axis distance from the family centre (V-shape). This method has been shown to be effective in the cases of the very diffuse families that formed billions of years ago. We obtained photometric observations of asteroids in order to construct their rotational light curves; we combine them with the literature light curves and sparse-in-time photometry; we input these data in the light curve inversion methods to determine the shape and the spin pole of the asteroids in order to assess whether an object is prograde or retrograde. The ultimate goal is to assess whether we find an excess of retrograde asteroids on the inward side of the V-shape of a 4 Gyr asteroid family identified via the V-shape method. This excess of retrograde rotators is predicted by the theory of asteroid family evolution. We obtained the spin poles for 55 asteroids claimed to belong to a 4 Gyr collisional family of the inner main belt that consists of low-albedo asteroids. After re-evaluating the albedo and spectroscopic information, we found that nine of these asteroids are interlopers in the 4 Gyr family. Of the 46 remaining asteroids, 31 are found to be retrograde and 15 prograde. We also found that these retrograde rotators have a very low probability (1.29%) of being due to random sampling from an underlying uniform distribution of spin poles. Our results constitute corroborating evidence that the asteroids identified as members of a 4 Gyr collisional family have a common origin, thus strengthening their family membership., Comment: 20 pages, 7 figures. A&A (2022)
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- 2022
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29. Sezary syndrome revealed by PD‐L1 blockade for tumor stage mycosis fungoides
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Jérémie Delaleu, Maxime Battistella, Caroline Ram‐Wolff, Hélène Moins‐Teisserenc, Van‐Anh Ta, Marie Roelens, Jacqueline Rivet, Céleste Lebbé, Samia Mourah, Baptiste Louveau, Jean‐David Bouaziz, Martine Bagot, and Adèle deMasson
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atezolizumab ,cutaneous T‐cell lymphoma ,mycosis fungoides ,Sezary syndrome ,Dermatology ,RL1-803 ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Cutaneous T‐cell lymphomas (CTCLs) are unique non‐Hodgkin lymphomas due to the proliferation of skin‐homing T cells. Sezary syndrome (SS), a subtype of CTCL, typically presents as erythroderma with specific blood involvement and seldomly evolves from tumor‐stage mycosis fungoides (MF). The article examines the case of a 62‐year‐old female patient who developed SS while under atezolizumab treatment for tumor‐stage transformed MF. Postdiagnosis, she underwent treatments including topical corticosteroids, phototherapy, and other drug regimens, experiencing both complete responses and relapses over the years. Three years postdiagnosis, her condition deteriorated with facial tumor lesions, confirmed as MF. Despite multiple treatments, including oral drugs, radiation therapy, and a range of other therapeutic agents, her condition did not show sustained improvement. The patient was then administered atezolizumab, an antibody targeting programmed death ligand 1 (PD‐L1). Although initial results saw a disappearance of her skin tumors, the subsequent cycles led to symptoms consistent with stage IVA1 SS, coupled with an evident shift in malignant T‐cell clone dominance. Atezolizumab, a humanized monoclonal antibody, impedes the interaction of PD‐L1 with its receptor PD1, which is notably overexpressed in malignant T‐cells of SS. This case illustrates the emergence of SS during the course of atezolizumab treatment for a transformed MF condition, underlining the potential risks and complexities in using PD‐L1 inhibitors for treating CTCL.
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- 2024
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30. Incarceration history and opioid use among adults living with HIV and chronic pain: a secondary analysis of a prospective cohort study
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Anna B. Lichtiger, Yuting Deng, Chenshu Zhang, Justina Groeger, Hector R. Perez, Gayatri Nangia, Melanie Prinz, Emma Richard, Matthew Glenn, Ana Alicia De La Cruz, Ariana Pazmino, Chinazo O. Cunningham, K Rivet Amico, Aaron Fox, and Joanna L. Starrels
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Incarceration ,Opioids ,Chronic pain ,HIV ,Public aspects of medicine ,RA1-1270 ,Social pathology. Social and public welfare. Criminology ,HV1-9960 - Abstract
Abstract Background Adults living with HIV have disproportionately high chronic pain, prescription opioid use, history of substance use, and incarceration. While incarceration can have long-lasting health impacts, prior studies have not examined whether distant (>1 year prior) incarceration is associated with opioid use for chronic pain, or with opioid misuse or opioid use disorder among people living with HIV and chronic pain. Methods We conducted a secondary analysis of a prospective cohort study of adults living with HIV and chronic pain. The independent variables were any distant incarceration and drug-related distant incarceration (both dichotomous). Dependent variables were current long-term opioid therapy, current opioid misuse, and current opioid use disorder. A series of multivariate logistic regression models were conducted, adjusting for covariates. Results In a cohort of 148 participants, neither distant incarceration nor drug-related incarceration history were associated with current long-term opioid therapy. Distant incarceration was associated with current opioid misuse (AOR 3.28; 95% CI: 1.41-7.61) and current opioid use disorder (AOR 4.40; 95% CI: 1.54-12.56). Drug-related incarceration history was also associated with current opioid misuse (AOR 4.31; 95% CI: 1.53-12.17) and current opioid use disorder (AOR 7.28; 95% CI: 2.06-25.71). Conclusions The positive associations of distant incarceration with current opioid misuse and current opioid use disorder could indicate a persistent relationship between incarceration and substance use in people living with HIV and chronic pain. Additional research on opioid use among formerly incarcerated individuals in chronic pain treatment is needed.
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- 2024
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31. The impact of intimate partner violence on PrEP adherence among U.S. Cisgender women at risk for HIV
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Katherine M. Anderson, Jill Blumenthal, Sonia Jain, Xiaoying Sun, K. Rivet Amico, Raphael Landovitz, Christine M. Zachek, Sheldon Morris, David J. Moore, and Jamila K. Stockman
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Intimate Partner violence ,Pre-exposure Prophylaxis for HIV Prevention ,Adherence ,Violence ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Cisgender women account for 1 in 5 new HIV infections in the United States, yet remain under-engaged in HIV prevention. Women experiencing violence face risk for HIV due to biological and behavioral mechanisms, and barriers to prevention, such as challenges to Pre-Exposure Prophylaxis for HIV Prevention (PrEP) adherence. In this analysis, we aim to characterize intimate partner violence (IPV) among cisgender heterosexual women enrolled in a PrEP demonstration project and assess the associations with PrEP adherence. Methods Adherence Enhancement Guided by Individualized Texting and Drug Levels (AEGiS) was a 48-week single-arm open-label study of PrEP adherence in HIV-negative cisgender women in Southern California (N = 130) offered daily tenofovir disoproxil fumarate/emtricitabine (TDF/FTC). From 6/2016 to 10/2018, women completed a survey reporting HIV risk behavior and experiences of any IPV (past 90-days) and IPV sub-types (past-year, lifetime) and biological testing for HIV/STIs at baseline, and concentrations of tenofovir-diphosphate (TFV-DP) in dried blood spots at weeks 4, 12, 24, 36, and 48. Outcomes were TFV-DP concentrations consistent with ≥ 4 or ≥ 6 doses/week at one or multiple visits. Multivariable logistic regression models were conducted to examine associations. Results Past-90-day IPV was reported by 34.4% of participants, and past-year and lifetime subtypes reported by 11.5-41.5%, and 21.5-52.3%, respectively. Women who engaged in sex work and Black women were significantly more likely to report IPV than others. Lifetime physical IPV was negatively associated with adherence at ≥ 4 doses/week at ≥ 3 of 5 visits, while other relationships with any IPV and IPV sub-types were variable. Conclusion IPV is an indication for PrEP and important indicator of HIV risk; our findings suggest that physical IPV may also negatively impact long-term PrEP adherence. Clinical Trials Registration NCT02584140 (ClinicalTrials.gov), registered 15/10/2015.
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- 2024
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32. A methodology for estimating SARS-CoV-2 importation risk by air travel into Canada between July and November 2021
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Rachael M. Milwid, Vanessa Gabriele-Rivet, Nicholas H. Ogden, Patricia Turgeon, Aamir Fazil, David London, Simon de Montigny, and Erin E. Rees
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COVID-19 ,Importation risk ,Air travel ,Mathematical model ,Pre-departure molecular testing ,Canada ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Estimating rates of disease importation by travellers is a key activity to assess both the risk to a country from an infectious disease emerging elsewhere in the world and the effectiveness of border measures. We describe a model used to estimate the number of travellers infected with SARS-CoV-2 into Canadian airports in 2021, and assess the impact of pre-departure testing requirements on importation risk. Methods A mathematical model estimated the number of essential and non-essential air travellers infected with SARS-CoV-2, with the latter requiring a negative pre-departure test result. The number of travellers arriving infected (i.e. imported cases) depended on air travel volumes, SARS-CoV-2 exposure risk in the departure country, prior infection or vaccine acquired immunity, and, for non-essential travellers, screening from pre-departure molecular testing. Importation risk was estimated weekly from July to November 2021 as the number of imported cases and percent positivity (PP; i.e. imported cases normalised by travel volume). The impact of pre-departure testing was assessed by comparing three scenarios: baseline (pre-departure testing of all non-essential travellers; most probable importation risk given the pre-departure testing requirements), counterfactual scenario 1 (no pre-departure testing of fully vaccinated non-essential travellers), and counterfactual scenario 2 (no pre-departure testing of non-essential travellers). Results In the baseline scenario, weekly imported cases and PP varied over time, ranging from 145 to 539 cases and 0.15 to 0.28%, respectively. Most cases arrived from the USA, Mexico, the United Kingdom, and France. While modelling suggested that essential travellers had a higher weekly PP (0.37 – 0.65%) than non-essential travellers (0.12 – 0.24%), they contributed fewer weekly cases (62 – 154) than non-essential travellers (84 – 398 per week) given their lower travel volume. Pre-departure testing was estimated to reduce imported cases by one third (counterfactual scenario 1) to one half (counterfactual scenario 2). Conclusions The model results highlighted the weekly variation in importation by traveller group (e.g., reason for travel and country of departure) and enabled a framework for measuring the impact of pre-departure testing requirements. Quantifying the contributors of importation risk through mathematical simulation can support the design of appropriate public health policy on border measures.
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- 2024
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33. Field and intensity correlations: the Siegert relation from stars to quantum emitters
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Lassègues, Pierre, Biscassi, Mateus Antônio Fernandes, Morisse, Martial, Cidrim, André, Matthews, Nolan, Labeyrie, Guillaume, Rivet, Jean-Pierre, Vakili, Farrokh, Kaiser, Robin, Guerin, William, Bachelard, Romain, and Hugbart, Mathilde
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Physics - Atomic Physics - Abstract
The Siegert relation relates field and intensity temporal correlations. After a historical review of the Siegert relation and the Hanbury Brown and Twiss effect, we discuss the validity of this relation in two different domains. We first show that this relation can be used in astrophysics to determine the fundamental parameters of stars, and that it is especially important for the observation with stellar emission lines. Second, we verify the validity of this relation for moving quantum scatterers illuminated by a strong driving field.
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- 2022
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34. Intensity Interferometry at Calern and beyond: progress report
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Matthews, Nolan, Rivet, Jean-Pierre, Hugbart, Mathilde, Labeyrie, Guillaume, Kaiser, Robin, Lai, Olivier, Vakili, Farrokh, Vernet, David, Chabé, Julien, Courde, Clémont, Schuhler, Nicolas, Bourget, Pierre, and Guerin, William
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present the current status of the I2C stellar intensity interferometer used towards high angular resolution observations of stars in visible wavelengths. In these proceedings, we present recent technical improvements to the instrument, and share results from ongoing campaigns using arrays of small diameter optical telescopes. A tip-tilt adaptive optics unit was integrated into the optical system to stabilize light injection into an optical fiber. The setup was successfully tested with several facilities on the Calern Plateau site of the Observatoire de la C\^ote d'Azur. These include one of the 1 m diameter telescopes of the C2PU observatory, a portable 1 m diameter telescope, and also the 1.5 m M\'eO telescope. To better constrain on-sky measurements, the spectral transmission of instrument was characterized in the laboratory using a high resolution spectrograph. The system was also tested with two of the auxiliary telescopes of the VLTI resulting in successful temporal and spatial correlation measurements of three stars.
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- 2022
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35. DeeperDive: The Unreasonable Effectiveness of Weak Supervision in Document Understanding A Case Study in Collaboration with UiPath Inc
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Elwany, Emad, Hegel, Allison, Shah, Marina, Roof, Brendan, Peaslee, Genevieve, and Rivet, Quentin
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Computer Science - Computation and Language - Abstract
Weak supervision has been applied to various Natural Language Understanding tasks in recent years. Due to technical challenges with scaling weak supervision to work on long-form documents, spanning up to hundreds of pages, applications in the document understanding space have been limited. At Lexion, we built a weak supervision-based system tailored for long-form (10-200 pages long) PDF documents. We use this platform for building dozens of language understanding models and have applied it successfully to various domains, from commercial agreements to corporate formation documents. In this paper, we demonstrate the effectiveness of supervised learning with weak supervision in a situation with limited time, workforce, and training data. We built 8 high quality machine learning models in the span of one week, with the help of a small team of just 3 annotators working with a dataset of under 300 documents. We share some details about our overall architecture, how we utilize weak supervision, and what results we are able to achieve. We also include the dataset for researchers who would like to experiment with alternate approaches or refine ours. Furthermore, we shed some light on the additional complexities that arise when working with poorly scanned long-form documents in PDF format, and some of the techniques that help us achieve state-of-the-art performance on such data.
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- 2022
36. The GRANDMA network in preparation for the fourth gravitational-wave observing run
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Agayeva, S., Aivazyan, V., Alishov, S., Almualla, M., Andrade, C., Antier, S., Bai, J. -M., Baransky, A., Basa, S., Bendjoya, P., Benkhaldoun, Z., Beradze, S., Berezin, D., Bhardwaj, U., Blazek, M., Burkhonov, O., Burns, E., Caudill, S., Christensen, N., Colas, F., Coleiro, A., Corradi, W., Coughlin, M. W., Culino, T., Darson, D., Datashvili, D., Dietrich, T., Dolon, F., Dornic, D., Dubouil, J., Ducoin, J. -G., Duverne, P. -A., Esamdin, A., Fouad, A., Guo, F., Godunova, V., Gokuldass, P., Guessoum, N., Gurbanov, E., Hainich, R., Hasanov, E., Hello, P., Hussenot-Desenonges, T., Inasaridze, R., Iskandar, A., Ishida, E. E. O., Ismailov, N., Laz, T. Jegou du, Kann, D. A., Kapanadze, G., Karpov, S., Kiendrebeogo, R. W., Klotz, A., Kochiashvili, N., Kaeouach, A., Kneib, J. -P., Kou, W., Kruiswijk, K., Lombardo, S., Lamoureux, M., Leroy, N., Van Su, A. Le, Mao, J., Masek, M., Midavaine, T., Moeller, A., Morris, D., Natsvlishvili, R., Navarete, F., Nissanke, S., Noonan, K., Noysena, K., Orange, N. B., Peloton, J., Pilloix, M., Pradier, T., Raaijmakers, G., Rajabov, Y., Rivet, J. -P., Romanyuk, Y., Rousselot, L., Ruenger, F., Rupchandani, V., Sadibekova, T., Sasaki, N., Smith, K., Sokoliuk, O., Song, X., Simon, A., Takey, A., Tillayev, Y., Melo, I. Tosta e, Turpin, D., Postigo, A. de Ugarte, Vardosanidze, M., Wang, X. F., de Wasseige, G., Vernet, D., Vidadi, Z., Zhu, J., and Zhu, Y.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
GRANDMA is a world-wide collaboration with the primary scientific goal of studying gravitational-wave sources, discovering their electromagnetic counterparts and characterizing their emission. GRANDMA involves astronomers, astrophysicists, gravitational-wave physicists, and theorists. GRANDMA is now a truly global network of telescopes, with (so far) 30 telescopes in both hemispheres. It incorporates a citizen science programme (Kilonova-Catcher) which constitutes an opportunity to spread the interest in time-domain astronomy. The telescope network is an heterogeneous set of already-existing observing facilities that operate coordinated as a single observatory. Within the network there are wide-field imagers that can observe large areas of the sky to search for optical counterparts, narrow-field instruments that do targeted searches within a predefined list of host-galaxy candidates, and larger telescopes that are devoted to characterization and follow-up of the identified counterparts. Here we present an overview of GRANDMA after the third observing run of the LIGO/VIRGO gravitational-wave observatories in $2019-2020$ and its ongoing preparation for the forthcoming fourth observational campaign (O4). Additionally, we review the potential of GRANDMA for the discovery and follow-up of other types of astronomical transients., Comment: Submitted to the Proceedings of the SPIE, Astronomical Telescopes and Instrumentation 2022
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- 2022
37. A Web-Based Antiretroviral Therapy Adherence Intervention (Thrive With Me) in a Community-Recruited Sample of Sexual Minority Men Living With HIV: Results of a Randomized Controlled Study
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Keith J Horvath, Sara Lammert, Darin Erickson, K Rivet Amico, Ali J Talan, Ore Shalhav, Christina J Sun, and H Jonathon Rendina
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundMost new HIV infections are attributed to male-to-male sexual contact in the United States. However, only two-thirds of sexual minority men living with HIV achieve an undetectable viral load (UVL). We tested a web-based antiretroviral therapy adherence intervention called Thrive with Me (TWM) with core features that included medication self-monitoring and feedback, HIV and antiretroviral therapy information, and a peer-to-peer exchange. ObjectiveWe assessed the efficacy of TWM on HIV UVL among adult (aged ≥18 years) sexual minority men. Moreover, we assessed the impact of overall engagement and engagement with specific intervention features on HIV UVL. MethodsIn total, 401 sexual minority men (mean age 39.1, SD 10.8 y; 230/384, 59.9% African American) in New York City were recruited between October 2016 and December 2019 and randomized to receive TWM (intervention) or a weekly email newsletter (control) for 5 months. Computerized assessments occurred at baseline and months 5, 11, and 17. The primary outcome was a dichotomous measure of HIV UVL (≤20 copies/μL). Generalized estimating equations with robust SEs were used to assess the effect of the TWM intervention on HIV UVL over the follow-up period in an unadjusted model and a model adjusted for baseline differences and then stratified by baseline recent drug use urinalysis. In secondary analyses, generalized linear models were used to estimate risk differences in the association of overall engagement with TWM (the sum of the number of days participants accessed ≥1 screen of the TWM intervention out of a possible 150 days) and engagement with specific TWM components on HIV UVL throughout the 17-month intervention period. ResultsParticipant retention was 88.5% (355/401; month 5), 81.8% (328/401; month 11), and 80.3% (322/401; month 17). No consistent differences in HIV UVL were found between those randomized to receive TWM or the control at the 5- (difference-in-differences [DD]=–7.8, 95% CI –21.1 to 5.5), 11- (DD=–13.9, 95% CI –27.7 to 0.04), or 17-month (DD=–8.2, 95% CI –22.0 to 5.7) time points, or when stratified by baseline recent drug use. However, those TWM-assigned participants with high overall levels of engagement (in the upper 25th percentile) were more likely to have an HIV UVL at the end of the 5-month active intervention period compared to those with low engagement (below the 75th percentile; risk difference=17.8, 95% CI 2.5-33.0) or no engagement (risk difference=19.4, 95% CI 3.3-35.5) in the intervention. Moreover, high engagement with the peer-to-peer exchange was associated with HIV UVL over time in unadjusted models. ConclusionsTWM did not have overall impacts on HIV UVL; however, it may assist some sexual minority men who are highly engaged with this web-based intervention in achieving HIV viral suppression. Trial RegistrationClinicalTrials.gov NCT02704208; https://clinicaltrials.gov/study/NCT02704208
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- 2024
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38. Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection
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Astrid Marchal, Elizabeth T. Cirulli, Iva Neveux, Evangelos Bellos, Ryan S. Thwaites, Kelly M. Schiabor Barrett, Yu Zhang, Ivana Nemes-Bokun, Mariya Kalinova, Andrew Catchpole, Stuart G. Tangye, András N. Spaan, Justin B. Lack, Jade Ghosn, Charles Burdet, Guy Gorochov, Florence Tubach, Pierre Hausfater, Clifton L. Dalgard, Shen-Ying Zhang, Qian Zhang, Christopher Chiu, Jacques Fellay, Joseph J. Grzymski, Vanessa Sancho-Shimizu, Laurent Abel, Jean-Laurent Casanova, Aurélie Cobat, Alexandre Bolze, Alessandro Aiuti, Saleh Al-Muhsen, Fahd Al-Mulla, Ali Amara, Mark S. Anderson, Evangelos Andreakos, Andrés A. Arias, Lisa M. Arkin, Hagit Baris Feldman, Paul Bastard, Alexandre Belot, Catherine M. Biggs, Dusan Bogunovic, Anastasiia Bondarenko, Alessandro Borghesi, Ahmed A. Bousfiha, Petter Brodin, Yenan Bryceson, Manish J. Butte, Giorgio Casari, John Christodoulou, Roger Colobran, Antonio Condino-Neto, Stefan N. Constantinescu, Megan A. Cooper, Murkesh Desai, Beth A. Drolet, Xavier Duval, Jamila El Baghdadi, Philippine Eloy, Sara Espinosa-Padilla, Carlos Flores, José Luis Franco, Antoine Froidure, Peter K. Gregersen, Bodo Grimbacher, Filomeen Haerynck, David Hagin, Rabih Halwani, Lennart Hammarström, James R. Heath, Elena W.Y. Hsieh, Eystein Husebye, Kohsuke Imai, Yuval Itan, Emmanuelle Jouanguy, Elżbieta Kaja, Timokratis Karamitros, Kai Kisand, Cheng-Lung Ku, Yu-Lung Lau, Yun Ling, Carrie L. Lucas, Tom Maniatis, Davood Mansouri, László Maródi, France Mentré, Isabelle Meyts, Joshua D. Milner, Kristina Mironska, Trine H. Mogensen, Tomohiro Morio, Lisa F.P. Ng, Luigi D. Notarangelo, Antonio Novelli, Giuseppe Novelli, Cliona O'Farrelly, Satoshi Okada, Keisuke Okamoto, Tayfun Ozcelik, Qiang Pan-Hammarström, Jean W. Pape, Rebeca Perez de Diego, Jordi Perez-Tur, David S. Perlin, Graziano Pesole, Anna M. Planas, Carolina Prando, Aurora Pujol, Anne Puel, Lluis Quintana-Murci, Sathishkumar Ramaswamy, Laurent Renia, Igor Resnick, Carlos Rodríguez-Gallego, Anna Sediva, Mikko R.J. Seppänen, Mohammad Shahrooei, Anna Shcherbina, Ondrej Slaby, Andrew L. Snow, Pere Soler-Palacín, Vassili Soumelis, Ivan Tancevski, Ahmad Abou Tayoun, Şehime Gülsün Temel, Christian Thorball, Pierre Tiberghien, Sophie Trouillet-Assant, Stuart E. Turvey, K. M. Furkan Uddin, Mohammed J. Uddin, Diederik van de Beek, Donald C. Vinh, Horst von Bernuth, Joost Wauters, Mayana Zatz, Pawel Zawadzki, Serge Bureau, Yannick Vacher, Anne Gysembergh-Houal, Lauren Demerville, Abla Benleulmi-Chaachoua, Sebastien Abad, Radhiya Abassi, Abdelrafie Abdellaoui, Abdelkrim Abdelmalek, Hendy Abdoul, Helene Abergel, Fariza Abeud, Sophie Abgrall, Noemie Abisror, Marylise Adechian, Nordine Aderdour, Hakeem Farid Admane, Frederic Adnet, Sara Afritt, Helene Agostini, Claire Aguilar, Sophie Agut, Tommaso Francesco Aiello, Marc Ait Kaci, Hafid Ait Oufella, Gokula Ajeenthiravasan, Virginie Alauzy, Fanny Alby-Laurent, Lucie Allard, Marie-Alexandra Alyanakian, Blanca Amador Borrero, Sabrina Amam, Lucile Amrouche, Marc Andronikof, Dany Anglicheau, Nadia Anguel, Djillali Annane, Mohammed Aounzou, Caroline Aparicio, Gladys Aratus, Jean-Benoit Arlet, Jeremy Arzoine, Elisabeth Aslangul, Mona Assefi, Adeline Aubry, Laetitia Audiffred, Etienne Audureau, Christelle Nathalie Auger, Jean-Charles Auregan, Celine Awotar, Sonia Ayllon Milla, Delphine Azan, Laurene Azemar, Billal Azzouguen, Marwa Bachir Elrufaai, Aïda Badsi, Prissile Bakouboula, Coline Balcerowiak, Fanta Balde, Elodie Baldivia, Eliane-Flore Bangamingo, Amandine Baptiste, Fanny Baran-Marszak, Caroline Barau, Nathalie Barget, Flore Baronnet, Romain Barthelemy, Jean-Luc Baudel, Camille Baudry, Elodie Baudry, Laurent Beaugerie, Adel Belamri, Nicolas Belaube, Rhida Belilita, Pierre Bellassen, Rawan Belmokhtar, Isabel Beltran, Ruben Benainous, Mourad Benallaoua, Robert Benamouzig, Amélie Benbara, Jaouad Benhida, Anis Benkhelouf, Jihene Benlagha, Chahinez Benmostafa, Skander Benothmane, Miassa Bentifraouine, Laurence Berard, Quentin Bernier, Enora Berti, Astrid Bertier, Laure Berton, Simon Bessis, Alexandra Beurton, Celine Bianco, Clara Bianquis, Frank Bidar, Philippe Blanche, Clarisse Blayau, Alexandre Bleibtreu, Emmanuelle Blin, Coralie Bloch-Queyrat, Marie-Christophe Boissier, Diane Bollens, Marion Bolzoni, Rudy pierre Bompard, Nicolas Bonnet, Justine Bonnouvrier, Shirmonecrystal Botha, Wissam Boucenna, Fatiha Bouchama, Olivier Bouchaud, Hanane Bouchghoul, Taoueslylia Boudjebla, Noel Boudjema, Catherine Bouffard, Adrien Bougle, Meriem Bouguerra, Leila Bouras, Agnes Bourcier, Anne Bourgarit Durand, Anne Bourrier, Fabrice Bouscarat, Diane Bouvry, Nesrine Bouziri, Ons Bouzrara, Sarah Bribier, Delphine Brugier, Melanie Brunel, Eida Bui, Anne Buisson, Iryna Bukreyeva, Côme Bureau, Jacques Cadranel, Johann Cailhol, Ruxandra Calin, Clara Campos Vega, Pauline Canavaggio, Marta Cancella, Delphine Cantin, Albert Cao, Lionel Carbillon, Nicolas Carlier, Clementine Cassard, Guylaine Castor, Marion Cauchy, Olivier Cha, Benjamin Chaigne, Salima Challal, Karine Champion, Patrick Chariot, Julie Chas, Simon Chauveau, Anthony Chauvin, Clement Chauvin, Nathalie Chavarot, Kamélia Chebbout, Mustapha Cherai, Ilaria Cherubini, Amelie Chevalier, Thibault Chiarabini, Thierry Chinet, Richard Chocron, Pascaline Choinier, Juliette Chommeloux, Christophe Choquet, Laure Choupeaux, Benjamin Chousterman, Dragosmarius Ciocan, Ada Clarke, Gaëlle Clavere, Florian Clavier, Karine Clement, Sebastien Clerc, Yves Cohen, Fleur Cohen, Adrien Cohen, Audrey Coilly, Hester Colboc, Pauline Colin, Magalie Collet, Chloé Comarmond, Emeline Combacon, Alain Combes, Celine Comparon, Jean-Michel Constantin, Hugues Cordel, Anne-Gael Cordier, Adrien Costantini, Nathalie Costedoat Chalumeau, Camille Couffignal, Doriane Coupeau, Alain Creange, Yannie Cuvillier Lamarre, Charlène Da Silveira, Sandrine Dautheville Guibal El Kayani, Nathalie De Castro, Yann De Rycke, Lucie Del Pozo, Quentin Delannoy, Mathieu Delay, Robin Deleris, Juliette Delforge, Laëtitia Delphine, Noemie Demare, Sophie Demeret, Alexandre Demoule, Aurore Deniau, François Depret, Sophie Derolez, Ouda Derradji, Nawal Derridj, Vincent Descamps, Lydia Deschamps, Celine Desconclois, Cyrielle Desnos, Karine Desongins, Robin Dhote, Benjamin Diallo, Morgane Didier, Myriam Diemer, Stephane Diez, Juliette Djadi-Prat, Fatima-Zohra Djamouri Monnory, Siham Djebara, Naoual Djebra, Minette Djietcheu, Hadjer Djillali, Nouara Djouadi, Severine Donneger, Catarina Dos Santos, Nathalie Dournon, Martin Dres, Laura Droctove, Marie Drogrey, Margot Dropy, Elodie Drouet, Valérie Dubosq, Evelyne Dubreucq, Estelle Dubus, Boris Duchemann, Thibault Duchenoy, Emmanuel Dudoignon, Romain Dufau, Florence Dumas, Clara Duran, Emmanuelle Duron, Antoine Durrbach, Claudine Duvivier, Nathan Ebstein, Jihane El Khalifa, Alexandre Elabbadi, Caroline Elie, Gabriel Ernotte, Anne Esling, Martin Etienne, Xavier Eyer, Muriel Sarah Fartoukh, Takoua Fayali, Marion Fermaut, Arianna Fiorentino, Souha Fliss, Marie-Céline Fournier, Benjamin Fournier, Hélène Francois, Olivia Freynet, Yvann Frigout, Isaure Fromont, Axelle Fuentes, Thomas Furet, Joris Galand, Marc Garnier, Agnes Gaubert, Stéphane Gaudry, Samuel Gaugain, Damien Gauthier, Maxime Gautier, Sophie Georgin-Lavialle, Daniela Geromin, Mohamed Ghalayini, Bijan Ghaleh, Myriam Ghezal, Aude Gibelin, Linda Gimeno, Benoit Girard, Bénédicte Giroux Leprieur, Doryan Gomes, Elisabete Gomes-Pires, Anne Gouge, Amel Gouja, Helene Goulet, Sylvain Goupil, Jeanne Goupil De Bouille, Julien Gras, Segolene Greffe, Lamiae Grimaldi, Paul Guedeney, Bertrand Guidet, Matthias Guillo, Mariechristelle Gulczynski, Tassadit Hadjam, Didier Haguenauer, Soumeya Hammal, Nadjib Hammoudi, Olivier Hanon, Anarole Harrois, Coraline Hautem, Guillaume Hekimian, Nicholas Heming, Olivier Hermine, Sylvie Ho, Marie Houllier, Benjamin Huot, Tessa Huscenot, Wafa Ibn Saied, Ghilas Ikherbane, Meriem Imarazene, Patrick Ingiliz, Lina Iratni, Stephane Jaureguiberry, Jean-Francois Jean-Marc, Deleena Jeyarajasingham, Pauline Jouany, Veronique Jouis, Clement Jourdaine, Ouifiya Kafif, Rim Kallala, Sandrine Katsahian, Lilit Kelesyan, Vixra Keo, Flora Ketz, Warda Khamis, Enfel Khelili, Mehdi Khellaf, Christy Gaëlla Kotokpo Youkou, Ilias Kounis, Gaelle Kpalma, Jessica Krause, Vincent Labbe, Karine Lacombe, Jean-Marc Lacorte, Anne Gaelle Lafont, Emmanuel Lafont, Lynda Lagha, Lionel Lamhaut, Aymeric Lancelot, Cecilia Landman, Fanny Lanternier, Cecile Larcheveque, Caroline Lascoux Combe, Ludovic Lassel, Benjamin Laverdant, Christophe Lavergne, Jean-Rémi Lavillegrand, Pompilia Lazureanu, Loïc Le Guennec, Lamia Leberre, Claire Leblanc, Marion Leboyer, Francois Lecomte, Marine Lecorre, Romain Leenhardt, Marylou Lefebvre, Bénédicte Lefebvre, Paul Legendre, Anne Leger, Laurence Legros, Justyna Legrosse, Sébastien Lehuunghia, Julien Lemarec, Jeremie Leporrier-Ext, Manon Lesein, Hubert Lesur, Vincent Levy, Albert Levy, Edwige Lopes, Amanda Lopes, Vanessa Lopez, Julien Lopinto, Olivier Lortholary, Badr Louadah, Bénédicte Loze, Marie-Laure Lucas, Axelle Lucasamichi, Liem Binh Luong, Arouna Magazimama-Ext, David Maingret, Lakhdar Mameri, Philippe Manivet, Cylia Mansouri, Estelle Marcault, Jonathan Marey, Nathalie Marin, Clémence Marois, Olivier Martin, Lou Martineau, Cannelle Martinez-Lopez, Pierre Martyniuck, Pauline Mary De Farcy, Nessrine Marzouk, Rafik Masmoudi, Alexandre Mebazaa, Frédéric Mechai, Fabio Mecozzi, Chamseddine Mediouni, Bruno Megarbane, Mohamed Meghadecha, Élodie Mejean, Arsene Mekinian, Nour Mekki Abdelhadi, Rania Mekni, Thinhinan Sabrina Meliti, Breno Melo Lima, Paris Meng, Soraya Merbah, Fadhila Messani, Yasmine Messaoudi, Baboo-Irwinsingh Mewasing, Lydia Meziane, Carole Michelot-Burger, Françoise Mignot, Fadi Hillary Minka, Makoto Miyara, Pierre Moine, Jean-Michel Molina, Anaïs Montegnies-Boulet, Alexandra Monti, Claire Montlahuc, Anne-Lise Montout, Alexandre Moores, Caroline Morbieu, Helene Mortelette, Stéphane Mouly, Rosita Muzaffar, Cherifa Iness Nacerddine, Marine Nadal, Hajer Nadif, Kladoum Nassarmadji, Pierre Natella, Sandrine Ndingamondze, Stefan Neraal, Caroline Nguyen, Bao N'Guyen, Isabelle Nion Larmurier, Luc Nlomenyengue, Nicolas Noel, Hilario Nunes, Edris Omar, Zineb Ouazene, Elise Ouedraogo, Wassila Ouelaa, Anissa Oukhedouma, Yasmina Ould Amara, Herve Oya, Johanna Oziel, Thomas Padilla, Elena Paillaud, Solenne Paiva, Beatrice Parfait, Perrine Parize, Christophe Parizot, Antoine Parrot, Arthur Pavot, Laetitia Peaudecerf, Frédéric Pene, Marion Pepin, Julie Pernet, Claire Pernin, Mylène Petit, Olivier Peyrony, Marie-Pierre Pietri, Olivia Pietri, Marc Pineton De Chambrun, Michelle Pinson, Claire Pintado, Valentine Piquard, Christine Pires, Benjamin Planquette, Sandrine Poirier, Anne-Laure Pomel, Stéphanie Pons, Diane Ponscarme, Annegaelle Pourcelot, Valérie Pourcher, Anne Pouvaret, Florian Prever, Miresta Previlon, Margot Prevost, Marie-Julie Provoost, Cyril Quemeneur, Cédric Rafat, Agathe Rami, Brigitte Ranque, Maurice Raphael, Jean Herle Raphalen, Anna Rastoin, Mathieu Raux, Amani Rebai, Michael Reby, Alexis Regent, Asma Regrag, Matthieu Resche-Rigon, Quentin Ressaire, Christian Richard, Mariecaroline Richard, Maxence Robert, Benjamin Rohaut, Camille Rolland-Debord, Jacques Ropers, Anne-Marie Roque-Afonso, Charlotte Rosso, Mélanie Rousseaux, Nabila Rousseaux, Swasti Roux, Lorène Roux, Claire Rouzaud, Antoine Rozes, Emma Rubenstein, Jean-Marc Sabate, Sheila Sabet, Sophie-Caroline Sacleux, Nathalie Saidenberg Kermanach, Faouzi Saliba, Dominique Salmon, Laurent Savale, Guillaume Savary, Rebecca Sberro, Anne Scemla, Frederic Schlemmer, Mathieu Schwartz, Saïd Sedfi, Samia Sefir-Kribel, Philippe Seksik, Pierre Sellier, Agathe Selves, Nicole Sembach, Luca Semerano, Marie-Victoire Senat, Damien Sene, Alexandra Serris, Lucile Sese, Naima Sghiouar, Johanna Sigaux, Martin Siguier, Johanne Silvain, Noémie Simon, Tabassome Simon, Lina Innes Skandri, Miassa Slimani, Aurélie Snauwaert, Harry Sokol, Heithem Soliman, Nisrine Soltani, Benjamin Soyer, Gabriel Steg, Lydia Suarez, Tali-Anne Szwebel, Kossi Taffame, Yacine Tandjaoui-Lambiotte, Claire Tantet, Mariagrazia Tateo, Igor Theodose, Pierre clement Thiebaud, Caroline Thomas, Kelly Tiercelet, Julie Tisserand, Carole Tomczak, Krystel Torelino, Fatima Touam-Ext, Lilia Toumi, Gustave Toury, Mireille Toy-Miou, Olivia Tran Dinh Thanh Lien, Alexy Trandinh, Jean-Marc Treluyer, Baptiste Trinque, Jennifer Truchot, Sarah Tubiana, Simone Tunesi, Matthieu Turpin, Agathe Turpin, Tomas Urbina, Rafael Usubillaga Narvaez, Yurdagul Uzunhan, Prabakar Vaittinadaayar, Arnaud Valent, Maelle Valentian, Nadia Valin, Hélène Vallet, Marina Vaz, Miguel-Alejandro Vazquezibarra, Benoit Vedie, Laetitia Velly, Celine Verstuyft, Cedric Viallette, Eric Vicaut, Dorothee Vignes, Damien Vimpere, Myriam Virlouvet, Guillaume Voiriot, Lena Voisot, Emmanuel Weiss, Nicolas Weiss, Anaïs Winchenne, Youri Yordanov, Lara Zafrani, Mohamad Zaidan, Wissem Zaidi, Cathia Zak, Aida Zarhrate-Ghoul, Ouassila Zatout, Suzanne Zeino, Michel Zeitouni, Naïma Zemirli, Lorene Zerah, Ounsa Zia, Marianne Ziol, Oceane Zolario, Julien Zuber, Claire Andrejak, François Angoulvant, Delphine Bachelet, Marie Bartoli, Romain Basmaci, Sylvie Behillil, Marine Beluze, Dehbia Benkerrou, Krishna Bhavsar, Lila Bouadma, Sabelline Bouchez, Maude Bouscambert, Minerva Cervantes-Gonzalez, Anissa Chair, Catherine Chirouze, Alexandra Coelho, Sandrine Couffin-Cadiergues, Eric d’Ortenzio, Marie-Pierre Debray, Laurene Deconinck, Dominique Deplanque, Diane Descamps, Mathilde Desvallée, Alpha Diallo, Alphonsine Diouf, Céline Dorival, François Dubos, Brigitte Elharrar, Vincent Enouf, Hélène Esperou, Marina Esposito-Farese, Manuel Etienne, Eglantine Ferrand Devouge, Nathalie Gault, Alexandre Gaymard, Tristan Gigante, Morgane Gilg, Jérémie Guedj, Alexandre Hoctin, Isabelle Hoffmann, Ikram Houas, Jean-Sébastien Hulot, Salma Jaafoura, Florentia Kaguelidou, Sabrina Kali, Antoine Khalil, Coralie Khan, Cédric Laouénan, Samira Laribi, Minh Le, Quentin Le Hingrat, Soizic Le Mestre, Hervé Le Nagard, François-Xavier Lescure, Sophie Letrou, Yves Levy, Bruno Lina, Guillaume Lingas, Jean-Christophe Lucet, Denis Malvy, Marina Mambert, Amina Meziane, Hugo Mouquet, Jimmy Mullaert, Nadège Neant, Duc Nguyen, Marion Noret, Saad Nseir, Aurélie Papadopoulos, Christelle Paul, Nathan Peiffer-Smadja, Thomas Perpoint, Ventzislava Petrov-Sanchez, Gilles Peytavin, Huong Pham, Olivier Picone, Oriane Puéchal, Christian Rabaud, Manuel Rosa-Calatrava, Bénédicte Rossignol, Patrick Rossignol, Carine Roy, Marion Schneider, Richa Su, Coralie Tardivon, Marie-Capucine Tellier, François Téoulé, Olivier Terrier, Jean-François Timsit, Christelle Tual, Sylvie Van Der Werf, Noémie Vanel, Aurélie Veislinger, Benoit Visseaux, Aurélie Wiedemann, Yazdan Yazdanpanah, Loubna Alavoine, Charlotte Charpentier, Aline Dechanet, Jean-Luc Ecobichon, Wahiba Frezouls, Nadhira Houhou, Jonathan Lehacaut, Pauline Manchon, Mariama Nouroudine, Caroline Quintin, Michael Thy, Sylvie van der Werf, Valérie Vignali, Abir Chahine, Nawal Waucquier, Maria-Claire Migaud, Félix Djossou, Mayka Mergeay-Fabre, Aude Lucarelli, Magalie Demar, Léa Bruneau, Patrick Gérardin, Adrien Maillot, Christine Payet, Bruno Laviolle, Fabrice Laine, Christophe Paris, Mireille Desille-Dugast, Julie Fouchard, Thierry Pistone, Pauline Perreau, Valérie Gissot, Carole L.E. Goas, Samatha Montagne, Lucie Richard, Kévin Bouiller, Maxime Desmarets, Alexandre Meunier, Marilou Bourgeon, Benjamin Lefévre, Hélène Jeulin, Karine Legrand, Sandra Lomazzi, Bernard Tardy, Amandine Gagneux-Brunon, Frédérique Bertholon, Elisabeth Botelho-Nevers, Christelle Kouakam, Leturque Nicolas, Layidé Roufai, Karine Amat, Hélène Espérou, Samia Hendou, Giuseppe Foti, Giuseppe Citerio, Ernesto Contro, Alberto Pesci, Maria Grazia Valsecchi, Marina Cazzaniga, Giacomo Bellani, Jorge Abad, Giulia Accordino, Micol Angelini, Sergio Aguilera-Albesa, Aina Aguiló-Cucurull, Esra Akyüz Özkan, Ilad Alavi Darazam, Jonathan Antonio Roblero Albisures, Juan C. Aldave, Miquel Alfonso Ramos, Taj Ali Khan, Anna Aliberti, Seyed Alireza Nadji, Gulsum Alkan, Suzan A. AlKhater, Jerome Allardet-Servent, Luis M. Allende, Rebeca Alonso-Arias, Mohammed S. Alshahrani, Laia Alsina, Zahir Amoura, Arnau Antolí, Romain Arrestier, Mélodie Aubart, Teresa Auguet, Iryna Avramenko, Gökhan Aytekin, Axelle Azot, Seiamak Bahram, Fanny Bajolle, Fausto Baldanti, Aurélie Baldolli, Maite Ballester, Benoit Barrou, Federica Barzaghi, Sabrina Basso, Gulsum Iclal Bayhan, Liliana Bezrodnik, Agurtzane Bilbao, Geraldine Blanchard-Rohner, Ignacio Blanco, Adeline Blandinières, Daniel Blázquez-Gamero, Marketa Bloomfield, Mireia Bolivar-Prados, Raphael Borie, Elisabeth Botdhlo-Nevers, Aurore Bousquet, David Boutolleau, Claire Bouvattier, Oksana Boyarchuk, Juliette Bravais, M. Luisa Briones, Marie-Eve Brunner, Raffaele Bruno, Maria Rita P. Bueno, Huda Bukhari, Jacinta Bustamante, Juan José Cáceres Agra, Ruggero Capra, Raphael Carapito, Maria Carrabba, Carlos Casasnovas, Marion Caseris, Irene Cassaniti, Martin Castelle, Francesco Castelli, Martín Castillo de Vera, Mateus V. Castro, Emilie Catherinot, Jale Bengi Celik, Alessandro Ceschi, Martin Chalumeau, Bruno Charbit, Cécile Boulanger, Père Clavé, Bonaventura Clotet, Anna Codina, Cloé Comarmond, Patrizia Comoli, Angelo G. Corsico, Taner Coşkuner, Aleksandar Cvetkovski, Cyril Cyrus, David Dalmau, François Danion, David Ross Darley, Vincent Das, Nicolas Dauby, Stéphane Dauger, Paul De Munte, Loic de Pontual, Amin Dehban, Geoffroy Delplancq, Isabelle Desguerre, Antonio Di Sabatino, Jean-Luc Diehl, Stephanie Dobbelaere, Elena Domínguez-Garrido, Clément Dubost, Olov Ekwall, Şefika Elmas Bozdemir, Marwa H. Elnagdy, Melike Emiroglu, Akifumi Endo, Emine Hafize Erdeniz, Selma Erol Aytekin, Maria Pilar Etxart Lasa, Romain Euvrard, Giovanna Fabio, Laurence Faivre, Antonin Falck, Muriel Fartoukh, Morgane Faure, Miguel Fernandez Arquero, Ricard Ferrer, Jose Ferreres, Bruno Francois, Victoria Fumadó, Kitty S.C. Fung, Francesca Fusco, Alenka Gagro, Blanca Garcia Solis, Pierre Garçon, Pascale Gaussem, Zeynep Gayretli, Juana Gil-Herrera, Laurent Gilardin, Audrey Giraud Gatineau, Mònica Girona-Alarcón, Karen Alejandra Cifuentes Godínez, Jean-Christophe Goffard, Nacho Gonzales, Luis I. Gonzalez-Granado, Rafaela González-Montelongo, Antoine Guerder, Belgin Gülhan, Victor Daniel Gumucio, Leif Gunnar Hanitsch, Jan Gunst, Marta Gut, Jérôme Hadjadj, Selda Hancerli, Tetyana Hariyan, Nevin Hatipoglu, Deniz Heppekcan, Elisa Hernandez-Brito, Po-ki Ho, María Soledad Holanda-Peña, Juan P. Horcajada, Sami Hraiech, Linda Humbert, Ivan F.N. Hung, Alejandro D. Iglesias, Antonio Íñigo-Campos, Matthieu Jamme, María Jesús Arranz, Marie-Thérèse Jimeno, Iolanda Jordan, Saliha Kanık-Yüksek, Yalcin Kara, Aydın Karahan, Adem Karbuz, Kadriye Kart Yasar, Ozgur Kasapcopur, Kenichi Kashimada, Sevgi Keles, Yasemin Kendir Demirkol, Yasutoshi Kido, Can Kizil, Ahmet Osman Kılıç, Adam Klocperk, Antonia Koutsoukou, Zbigniew J. Król, Hatem Ksouri, Paul Kuentz, Arthur M.C. Kwan, Yat Wah M. Kwan, Janette S.Y. Kwok, Jean-Christophe Lagier, David S.Y. Lam, Vicky Lampropoulou, Fleur Le Bourgeois, Yee-Sin Leo, Rafael Leon Lopez, Daniel Leung, Michael Levin, Michael Levy, Romain Lévy, Zhi Li, Daniele Lilleri, Edson Jose Adrian Bolanos Lima, Agnes Linglart, Eduardo López-Collazo, José M. Lorenzo-Salazar, Céline Louapre, Catherine Lubetzki, Kwok-Cheung Lung, Charles-Edouard Luyt, David C. Lye, Cinthia Magnone, Enrico Marchioni, Carola Marioli, Majid Marjani, Laura Marques, Jesus Marquez Pereira, Andrea Martín-Nalda, David Martínez Pueyo, Javier Martinez-Picado, Iciar Marzana, Carmen Mata-Martínez, Alexis Mathian, Larissa R.B. Matos, Gail V. Matthews, Julien Mayaux, Raquel McLaughlin-Garcia, Philippe Meersseman, Jean-Louis Mège, Armand Mekontso-Dessap, Isabelle Melki, Federica Meloni, Jean-François Meritet, Paolo Merlani, Özge Metin Akcan, Mehdi Mezidi, Isabelle Migeotte, Maude Millereux, Matthieu Million, Tristan Mirault, Clotilde Mircher, Mehdi Mirsaeidi, Yoko Mizoguchi, Bhavi P. Modi, Francesco Mojoli, Elsa Moncomble, Abián Montesdeoca Melián, Antonio Morales Martinez, Francisco Morandeira, Pierre-Emmanuel Morange, Clémence Mordacq, Guillaume Morelle, Stéphane J. Mouly, Adrián Muñoz-Barrera, Cyril Nafati, Shintaro Nagashima, Yu Nakagama, Bénédicte Neven, João Farela Neves, Yuk-Yung Ng, Hubert Nielly, Yeray Novoa Medina, Esmeralda Nuñez Cuadros, Semsi Nur Karabela, J. Gonzalo Ocejo-Vinyals, Mehdi Oualha, Amani Ouedrani, Tayfun Özçelik, Aslinur Ozkaya-Parlakay, Michele Pagani, Maria Papadaki, Philippe Parola, Tiffany Pascreau, Stéphane Paul, Estela Paz-Artal, Sigifredo Pedraza, Nancy Carolina González Pellecer, Silvia Pellegrini, Rebeca Pérez de Diego, Xosé Luis Pérez-Fernández, Aurélien Philippe, Quentin Philippot, Adrien Picod, Marc Pineton de Chambrun, Antonio Piralla, Laura Planas-Serra, Dominique Ploin, Julien Poissy, Géraldine Poncelet, Garyphallia Poulakou, Marie S. Pouletty, Persia Pourshahnazari, Jia Li Qiu-Chen, Paul Quentric, Thomas Rambaud, Didier Raoult, Violette Raoult, Anne-Sophie Rebillat, Claire Redin, Léa Resmini, Pilar Ricart, Jean-Christophe Richard, Raúl Rigo-Bonnin, Nadia Rivet, Jacques G. Rivière, Gemma Rocamora-Blanch, Mathieu P. Rodero, Carlos Rodrigo, Luis Antonio Rodriguez, Carlos Rodriguez-Gallego, Agustí Rodriguez-Palmero, Carolina Soledad Romero, Anya Rothenbuhler, Damien Roux, Nikoletta Rovina, Flore Rozenberg, Yvon Ruch, Montse Ruiz, Maria Yolanda Ruiz del Prado, Juan Carlos Ruiz-Rodriguez, Joan Sabater-Riera, Kai Saks, Maria Salagianni, Oliver Sanchez, Adrián Sánchez-Montalvá, Silvia Sánchez-Ramón, Laire Schidlowski, Agatha Schluter, Julien Schmidt, Matthieu Schmidt, Catharina Schuetz, Cyril E. Schweitzer, Francesco Scolari, Luis Seijo, Analia Gisela Seminario, Piseth Seng, Sevtap Senoglu, Mikko Seppänen, Alex Serra Llovich, Virginie Siguret, Eleni Siouti, David M. Smadja, Nikaia Smith, Ali Sobh, Xavier Solanich, Jordi Solé-Violán, Catherine Soler, Betül Sözeri, Giulia Maria Stella, Yuriy Stepanovskiy, Annabelle Stoclin, Fabio Taccone, Jean-Luc Taupin, Simon J. Tavernier, Loreto Vidaur Tello, Benjamin Terrier, Guillaume Thiery, Karolina Thorn, Caroline Thumerelle, Imran Tipu, Martin Tolstrup, Gabriele Tomasoni, Julie Toubiana, Josep Trenado Alvarez, Vasiliki Triantafyllia, Jesús Troya, Owen T.Y. Tsang, Liina Tserel, Eugene Y.K. Tso, Alessandra Tucci, Şadiye Kübra Tüter Öz, Matilde Valeria Ursini, Takanori Utsumi, Pierre Vabres, Juan Valencia-Ramos, Ana Maria Van Den Rym, Isabelle Vandernoot, Valentina Velez-Santamaria, Silvia Patricia Zuniga Veliz, Mateus C. Vidigal, Sébastien Viel, Cédric Villain, Marie E. Vilaire-Meunier, Judit Villar-García, Audrey Vincent, Dimitri Van der Linden, Alla Volokha, Fanny Vuotto, Els Wauters, Alan K.L. Wu, Tak-Chiu Wu, Aysun Yahşi, Osman Yesilbas, Mehmet Yildiz, Barnaby E. Young, Ufuk Yükselmiş, Marco Zecca, Valentina Zuccaro, Jens Van Praet, Bart N. Lambrecht, Eva Van Braeckel, Cédric Bosteels, Levi Hoste, Eric Hoste, Fré Bauters, Jozefien De Clercq, Catherine Heijmans, Hans Slabbynck, Leslie Naesens, Benoit Florkin, Mary-Anne Young, Amanda Willis, Paloma Lapuente-Suanzes, Ana de Andrés-Martín, Matilda Berkell, Valerio Carelli, Alessia Fiorentino, Surbhi Malhotra, Alessandro Mattiaccio, Tommaso Pippucci, Marco Seri, Evelina Tacconelli, Michiel van Agtmael, Anne Geke Algera, Brent Appelman, Frank van Baarle, Diane Bax, Martijn Beudel, Harm Jan Bogaard, Marije Bomers, Peter Bonta, Lieuwe Bos, Michela Botta, Justin de Brabander, Godelieve de Bree, Sanne de Bruin, David T.P. Buis, Marianna Bugiani, Esther Bulle, Osoul Chouchane, Alex Cloherty, Mirjam Dijkstra, Dave A. Dongelmans, Romein W.G. Dujardin, Paul Elbers, Lucas Fleuren, Suzanne Geerlings, Theo Geijtenbeek, Armand Girbes, Bram Goorhuis, Martin P. Grobusch, Florianne Hafkamp, Laura Hagens, Jorg Hamann, Vanessa Harris, Robert Hemke, Sabine M. Hermans, Leo Heunks, Markus Hollmann, Janneke Horn, Joppe W. Hovius, Menno D. de Jong, Rutger Koning, Endry H.T. Lim, Niels van Mourik, Jeaninne Nellen, Esther J. Nossent, Frederique Paulus, Edgar Peters, Dan A.I. Pina-Fuentes, Tom van der Poll, Bennedikt Preckel, Jan M. Prins, Jorinde Raasveld, Tom Reijnders, Maurits C.F. J. de Rotte, Michiel Schinkel, Marcus J. Schultz, Femke A.P. Schrauwen, Alex Schuurmans, Jaap Schuurmans, Kim Sigaloff, Marleen A. Slim, Patrick Smeele, Marry Smit, Cornelis S. Stijnis, Willemke Stilma, Charlotte Teunissen, Patrick Thoral, Anissa M. Tsonas, Pieter R. Tuinman, Marc van der Valk, Denise P. Veelo, Carolien Volleman, Heder de Vries, Lonneke A. Vught, Michèle van Vugt, Dorien Wouters, A.H. Zwinderman, Matthijs C. Brouwer, W. Joost Wiersinga, Alexander P.J. Vlaar, Miranda F. Tompkins, Camille Alba, Daniel N. Hupalo, John Rosenberger, Gauthaman Sukumar, Matthew D. Wilkerson, Xijun Zhang, Justin Lack, Andrew J. Oler, Kerry Dobbs, Ottavia M. Delmonte, Jeffrey J. Danielson, Andrea Biondi, Laura Rachele Bettini, Mariella D’Angiò, Ilaria Beretta, Luisa Imberti, Alessandra Sottini, Virginia Quaresima, Eugenia Quiros-Roldan, Camillo Rossi, Riccardo Castagnoli, Daniela Montagna, Amelia Licari, and Gian Luigi Marseglia
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HLA ,association ,asymptomatic infection ,COVID-19 ,population stratification ,Genetics ,QH426-470 - Abstract
Summary: Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B∗15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the three HLA-B∗15:01 individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.
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- 2024
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39. Extensible Machine Learning for Encrypted Network Traffic Application Labeling via Uncertainty Quantification
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Jorgensen, Steven, Holodnak, John, Dempsey, Jensen, de Souza, Karla, Raghunath, Ananditha, Rivet, Vernon, DeMoes, Noah, Alejos, Andrés, and Wollaber, Allan
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Computer Science - Cryptography and Security ,Computer Science - Machine Learning ,68T07 (Primary), 68M25 (Secondary) ,I.2.6 ,K.6.5 - Abstract
With the increasing prevalence of encrypted network traffic, cyber security analysts have been turning to machine learning (ML) techniques to elucidate the traffic on their networks. However, ML models can become stale as new traffic emerges that is outside of the distribution of the training set. In order to reliably adapt in this dynamic environment, ML models must additionally provide contextualized uncertainty quantification to their predictions, which has received little attention in the cyber security domain. Uncertainty quantification is necessary both to signal when the model is uncertain about which class to choose in its label assignment and when the traffic is not likely to belong to any pre-trained classes. We present a new, public dataset of network traffic that includes labeled, Virtual Private Network (VPN)-encrypted network traffic generated by 10 applications and corresponding to 5 application categories. We also present an ML framework that is designed to rapidly train with modest data requirements and provide both calibrated, predictive probabilities as well as an interpretable "out-of-distribution" (OOD) score to flag novel traffic samples. We describe calibrating OOD scores using p-values of the relative Mahalanobis distance. We demonstrate that our framework achieves an F1 score of 0.98 on our dataset and that it can extend to an enterprise network by testing the model: (1) on data from similar applications, (2) on dissimilar application traffic from an existing category, and (3) on application traffic from a new category. The model correctly flags uncertain traffic and, upon retraining, accurately incorporates the new data., Comment: Paper is 15 pages and has 10 figures. Published in IEEE Transactions on Artificial Intelligence (https://doi.org/10.1109/TAI.2023.3244168). For associated dataset, see https://www.ll.mit.edu/r-d/datasets/vpnnonvpn-network-application-traffic-dataset-vnat
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- 2022
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40. Combined spectroscopy and intensity interferometry to determine the distances of the blue supergiants P Cygni and Rigel
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de Almeida, E. S. G., Hugbart, Mathilde, de Souza, Armando Domiciano, Rivet, Jean-Pierre, Vakili, Farrokh, Siciak, Antonin, Labeyrie, Guillaume, Garde, Olivier, Matthews, Nolan, Lai, Olivier, Vernet, David, Kaiser, Robin, and Guerin, William
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
In this paper we report on spatial intensity interferometry measurements within the H$\alpha$ line on two stars: the Luminous Blue Variable supergiant \PCygni\,and the late-type B supergiant Rigel. The experimental setup was upgraded to allow simultaneous measurement of two polarization channels, instead of one in our previous setup, and the zero baseline correlation function on-sky to validate independent estimates obtained from the stellar spectrum and the instrumental spectral throughput. Combined with simultaneous spectra measurements and based on radiative transfer models calculated with the code CMFGEN, we were able to fit our measured visibility curves to extract the stellar distances. Our distance determinations for both \PCygni\ (1.61 $\pm$ 0.18 kpc) and Rigel (0.26 $\pm$ 0.02 kpc) agree very well with the values provided by astrometry with the Gaia and Hipparcos missions, respectively. This result for Rigel was obtained by adopting a stellar luminosity of $L_{\star}$ = 123000 $L_{\odot}$, which is reported in the literature as being consistent with the Hipparcos distance to Rigel. However, due to the lack of consensus on Rigel's luminosity, we also explore how the adoption of the stellar luminosity in our models affects our distance determination for Rigel. In conclusion, we support, in an independent way, the distance to Rigel as the one provided by the Hipparcos mission, when taking the luminosity of 123000 $L_{\odot}$ at face value. This study is the first successful step towards extending the application of the Wind Momentum Luminosity Relation method for distance calibration from an LBV supergiant to a more normal late-type B supergiant., Comment: Monthly Notices of the Royal Astronomical Society: Letters, Oxford Journals, In press
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- 2022
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41. Meeting the Socio-Emotional Needs of LGTBQ Students in Schools
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Rivet, Christopher
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Many LGTBQ youth struggle to be included in schools and have their emotional needs appropriately met. As a result, their identity and overall self-concept suffer due to unsafe school environments, poor peer relationships, and poor engagement within the school. Schools need to address these concerns and provide safe and inclusive environments that support the emotional well-being of LGTBQ students. Without these supports, students will likely continue to become disconnected and disengaged from their education due to adverse experiences that are common to many LGTBQ youth.
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- 2021
42. Constraints on the structure and seasonal variations of Triton's atmosphere from the 5 October 2017 stellar occultation and previous observations
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Oliveira, J. Marques, Sicardy, B., Gomes-Júnior, A. R., Ortiz, J. L., Strobel, D. F., Bertrand, T., Forget, F., Lellouch, E., Desmars, J., Bérard, D., Doressoundiram, A., Lecacheux, J., Leiva, R., Meza, E., Roques, F., Souami, D., Widemann, T., Santos-Sanz, P., Morales, N., Duffard, R., Fernández-Valenzuela, E., Castro-Tirado, A. J., Braga-Ribas, F., Morgado, B. E., Assafin, M., Camargo, J. I. B., Vieira-Martins, R., Benedetti-Rossi, G., Santos-Filho, S., Banda-Huarca, M. V., Quispe-Huaynasi, F., Pereira, C. L., Rommel, F. L., Margoti, G., Dias-Oliveira, A., Colas, F., Berthier, J., Renner, S., Hueso, R., Pérez-Hoyos, S., Sánchez-Lavega, A., Rojas, J. F., Beisker, W., Kretlow, M., Herald, D., Gault, D., Bath, K. -L., Bode, H. -J., Bredner, E., Guhl, K., Haymes, T. V., Hummel, E., Kattentidt, B., Klös, O., Pratt, A., Thome, B., Avdellidou, C., Gazeas, K., Karampotsiou, E., Tzouganatos, L., Kardasis, E., Christou, A. A., Xilouris, E. M., Alikakos, I., Gourzelas, A., Liakos, A., Charmandaris, V., Jelínek, M., Štrobl, J., Eberle, A., Rapp, K., Gährken, B., Klemt, B., Kowollik, S., Bitzer, R., Miller, M., Herzogenrath, G., Frangenberg, D., Brandis, L., Pütz, I., Perdelwitz, V., Piehler, G. M., Riepe, P., von Poschinger, K., Baruffetti, P., Cenadelli, D., Christille, J. -M., Ciabattari, F., Di Luca, R., Alboresi, D., Leto, G., Sanchez, R. Zanmar, Bruno, P., Occhipinti, G., Morrone, L., Cupolino, L., Noschese, A., Vecchione, A., Scalia, C., Savio, R. Lo, Giardina, G., Kamoun, S., Barbosa, R., Behrend, R., Spano, M., Bouchet, E., Cottier, M., Falco, L., Gallego, S., Tortorelli, L., Sposetti, S., Sussenbach, J., Abbeel, F. Van Den, André, P., Llibre, M., Pailler, F., Ardissone, J., Boutet, M., Sanchez, J., Bretton, M., Cailleau, A., Pic, V., Granier, L., Chauvet, R., Conjat, M., Dauvergne, J. L., Dechambre, O., Delay, P., Delcroix, M., Rousselot, L., Ferreira, J., Machado, P., Tanga, P., Rivet, J. -P., Frappa, E., Irzyk, M., Jabet, F., Kaschinski, M., Klotz, A., Rieugnie, Y., Klotz, A. N., Labrevoir, O., Lavandier, D., Walliang, D., Leroy, A., Bouley, S., Lisciandra, S., Coliac, J. -F., Metz, F., Erpelding, D., Nougayrède, P., Midavaine, T., Miniou, M., Moindrot, S., Morel, P., Reginato, B., Reginato, E., Rudelle, J., Tregon, B., Tanguy, R., David, J., Thuillot, W., Hestroffer, D., Vaudescal, G., Aissa, D. Baba, Grigahcene, Z., Briggs, D., Broadbent, S., Denyer, P., Haigh, N. J., Quinn, N., Thurston, G., Fossey, S. J., Arena, C., Jennings, M., Talbot, J., Alonso, S., Reche, A. Román, Casanova, V., Briggs, E., Iglesias-Marzoa, R., Ibáñez, J. Abril, Martín, M. C. Díaz, González, H., García, J. L. Maestre, Marchant, J., Ordonez-Etxeberria, I., Martorell, P., Salamero, J., Organero, F., Ana, L., Fonseca, F., Peris, V., Brevia, O., Selva, A., Perello, C., Cabedo, V., Gonçalves, R., Ferreira, M., Dias, F. Marques, Daassou, A., Barkaoui, K., Benkhaldoun, Z., Guennoun, M., Chouqar, J., Jehin, E., Rinner, C., Lloyd, J., Moutamid, M. El, Lamarche, C., Pollock, J. T., Caton, D. B., Kouprianov, V., Timerson, B. W., Blanchard, G., Payet, B., Peyrot, A., Teng-Chuen-Yu, J. -P., Françoise, J., Mondon, B., Payet, T., Boissel, C., Castets, M., Hubbard, W. B., Hill, R., Reitsema, H. J., Mousis, O., Ball, L., Neilsen, G., Hutcheon, S., Lay, K., Anderson, P., Moy, M., Jonsen, M., Pink, I., Walters, R., and Downs, B.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
A stellar occultation by Neptune's main satellite, Triton, was observed on 5 October 2017 from Europe, North Africa, and the USA. We derived 90 light curves from this event, 42 of which yielded a central flash detection. We aimed at constraining Triton's atmospheric structure and the seasonal variations of its atmospheric pressure since the Voyager 2 epoch (1989). We also derived the shape of the lower atmosphere from central flash analysis. We used Abel inversions and direct ray-tracing code to provide the density, pressure, and temperature profiles in the altitude range $\sim$8 km to $\sim$190 km, corresponding to pressure levels from 9 {\mu}bar down to a few nanobars. Results. (i) A pressure of 1.18$\pm$0.03 {\mu}bar is found at a reference radius of 1400 km (47 km altitude). (ii) A new analysis of the Voyager 2 radio science occultation shows that this is consistent with an extrapolation of pressure down to the surface pressure obtained in 1989. (iii) A survey of occultations obtained between 1989 and 2017 suggests that an enhancement in surface pressure as reported during the 1990s might be real, but debatable, due to very few high S/N light curves and data accessible for reanalysis. The volatile transport model analysed supports a moderate increase in surface pressure, with a maximum value around 2005-2015 no higher than 23 {\mu}bar. The pressures observed in 1995-1997 and 2017 appear mutually inconsistent with the volatile transport model presented here. (iv) The central flash structure does not show evidence of an atmospheric distortion. We find an upper limit of 0.0011 for the apparent oblateness of the atmosphere near the 8 km altitude., Comment: 52 pages, 26 figures in the main paper, 2 figures in appendix B, 9 figures in appendix C, 1 long table over 5 pages
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- 2022
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43. Acceptability of a Combination Adherence Strategy to Support HIV Antiretroviral Therapy and Pre-exposure Prophylaxis Adherence During Pregnancy and Breastfeeding in Malawi
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Saidi, Friday, Phanga, Twambilile, Graybill, Lauren A., Mollan, Katie R., Hill, Lauren M., Sibande, Watson, Msowoya, Getrude, Thom, Annie, Rosenberg, Nora E., Freeborn, Kellie, Amico, K. Rivet, Phiri, Sam, Mutale, Wilbroad, and Chi, Benjamin H.
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- 2023
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44. Quality improvement collaborative for improving patient care delivery in Argentine public health sector intensive care units
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Gabriela Sanchez, Javier Roberti, Luz Gibbons, Ezequiel García-Elorrio, Viviana Rodriguez, Viviana Chediack, Maria del Pilar Arias López, Cecilia Inés Loudet, Facundo Jorro Barón, Rosa Reina, Silvia Liliana Alegría, Cecilia del Valle Barrios, Rodolfo Buffa, María Laura Cabana, Eleonora Roxana Cunto, Simón Fernández Nievas, Mariel Ayelén García, Gabriela Izzo, María Natalia Llanos, Claudia Meregalli, José Joaquín Mira, María Elena Ratto, Mariano Luis Rivet, Ana María Silvestri, Analía Tévez, Leonardo Joaquín Uranga, Graciela Zakalik, Laura Paggi, Jacqueline Vilca Becerra, Ivanna Rodríguez, José Gelmetti, Agustina Paglia, Magali Villacorta, Fernando Luna, Christian Vanini, Alicia Sirino, Carina Balasini, Elizabeth Johanna Bastías Saez, Mariela Viviana Fumale, Leticia Fernanda Castillo, Alejandra del Valle Rodríguez, Andrea Elizabeth Vitale, Yanina Luz Vernetti, Eliseo Velásquez Chambi, Aracelly Pérez Flores, Itala Talamas Hurtado, Marta Verduguez, Verónica Bortoli, Maximiliano Carmona, Matías Caponi, Melisa Chocobar, Flavia Badilla, Gisela Videla, Cecilia Conil, Analía Ileana Resguardo, Silvia Susana González, Elizabeth Rodríguez Muñoz, Rosana Gregori, José Antonio Almeida, Cecilia Verónica Domínguez, Olga Zulema Tejerina, Susana Tejerina, Cintya Tintilay, Malena Lamas, Dalma Gutiérrez, Patricia Báez, Valeria Aguiar, Josefa Galán, María Eugenia Gauna, Daniela Olmos Kutscherauer, Andrea Marcolini, Fernando David Fernández, Luis Fernando Castellano, Silvia Edith Catalini, Gladys Myriam Aramayo, Luciano Inowlocki Calejman, María Luz Torrico, Liliana González, Vilma Villavicencio, Javier Julián Ortega, Pablo Nicolás Taborda, Martín Américo Moreno, Silvina Maricel Moyano, Sebastian Vacas, Claudia del Valle Fernández, Clemente Mamani, Sabrina Guillén, Karina Maciel, Silvia Laura Fernández, Gustavo Plotnikow, Cecilia Florencia Pereyra, Inés Suárez Anzorena, Marianela Lescano, and Marina Guglielmino
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Medicine (General) ,R5-920 - Abstract
Background The demand for healthcare services during the COVID-19 pandemic was excessive for less-resourced settings, with intensive care units (ICUs) taking the heaviest toll.Objective The aim was to achieve adequate personal protective equipment (PPE) use in 90% of patient encounters, to reach 90% compliance with objectives of patient flow (OPF) and to provide emotional support tools to 90% of healthcare workers (HCWs).Methods We conducted a quasi-experimental study with an interrupted time-series design in 14 ICUs in Argentina. We randomly selected adult critically ill patients admitted from July 2020 to July 2021 and active HCWs in the same period. We implemented a quality improvement collaborative (QIC) with a baseline phase (BP) and an intervention phase (IP). The QIC included learning sessions, periods of action and improvement cycles (plan-do-study-act) virtually coached by experts via platform web-based activities. The main study outcomes encompassed the following elements: proper utilisation of PPE, compliance with nine specific OPF using daily goal sheets through direct observations and utilisation of a web-based tool for tracking emotional well-being among HCWs.Results We collected 7341 observations of PPE use (977 in BP and 6364 in IP) with an improvement in adequate use from 58.4% to 71.9% (RR 1.2, 95% CI 1.17 to 1.29, p
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- 2024
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45. Skin involvement in systemic lymphoma of follicular helper T‐cell origin: A cohort study of 57 patients
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Romain Stammler, Maxime Battistella, Julien Calvani, Baptiste Louveau, François Lemonnier, Saskia Ingen‐Housz Oro, Nicolas Ortonne, Jean David Bouaziz, Jacqueline Rivet, Marie‐Dominique Vignon‐Pennamen, David Boutboul, Caroline Ram‐Wolff, Lionel Galicier, Catherine Thieblemont, Pauline Brice, Loïc Renaud, Geraldine Jeudy, Marie Beylot‐Barry, Christian Le Clech, Charlée Nardin, Jean‐Michel Cayuela, Véronique Meignin, Samia Mourah, Martine Bagot, Adèle De Masson, and French Study Group on Cutaneous Lymphomas
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angioimmunoblastic T‐cell lymphoma ,cutaneous T‐cell lymphoma ,T follicular helper cells ,T follicular helper lymphoma ,Dermatology ,RL1-803 ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background Angioimmunoblastic T‐cell lymphoma (AITL) is one of the most frequent peripheral T‐cell lymphomas (PTCL) in western countries. Skin involvement is common and may reveal the malignancy. Despite its frequency, skin involvement in AITL has been poorly described. Objectives We aimed to analyze the cutaneous expression of PTCL of TFH origin and its prognostic impact. Methods We conducted a multicenter retrospective cohort study by retrieving histopathological reports including the mention ‘AITL’ or ‘PTCL with T‐follicular helper phenotype’ (PTCL‐TFH) from five French tertiary hospital centers. Results From 2000 to 2022, we reviewed 382 histopathological records and identified 52 AITL cases and 5 PTCL‐TFH cases with cutaneous involvement. Thirty‐two (56%) patients were males with a mean age of 63 years. Fifty‐six (98%) patients presented with lymphadenopathy, 32 (56%) splenomegaly and 17 (30%) hepatomegaly. B signs were present in 34 (60%) patients. Skin lesions were present on the lower limbs in 44 (77%) patients, trunk in 38 (67%) patients, upper limbs in 35 (61%) and head in 27 (47%). Macules and papules were the most frequent lesions found in 47 (82%) patients, followed by nodules in 10 (17%) patients, erythemato‐squamous plaques in 10 (17%) patients, purpura in 9 (16%), urticaria in 9 (16%) and blisters in 5 (9%) patients. Erythroderma affected seven patients (12%). A skin biopsy was taken in 50 patients and revealed a specific lymphomatous infiltrate in 36 cases. A dominant skin T‐cell clone was detected in 13 out of 17 (76%) patients. Among the 14 patients with a nonspecific dermatitis, various histopathological patterns were observed including interface dermatitis, psoriasiform dermatitis, vasculitis, bullous dermatitis, granulomatous dermatitis and thrombotic vasculopathy. After a median follow‐up of 24 months (range, 0–121 months), median overall survival was 121 months (95% CI, 25.2–NA). At last follow‐up, 33 patients (58%) were alive, 20 (35%) were in complete remission and 7 (12%) were in partial remission; 30 (53%) patients experienced at least one relapse, including nodal relapses in 24 (80%) cases and cutaneous relapses in 12 (40%). Conclusions This study revealed the deep heterogeneity of skin presentations in AITL. Atypical skin presentations were common and included blistering, purpuric and psoriasiform eruptions.
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- 2023
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46. Adaptive evaluation of mHealth and conventional adherence support interventions to optimize outcomes with new treatment regimens for drug-resistant tuberculosis and HIV in South Africa (ADAP-TIV): study protocol for an adaptive randomized controlled trial
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Jesse Ross, Rubeshan Perumal, Allison Wolf, Mbali Zulu, Kevin Guzman, Boitumelo Seepamore, Karl Reis, Hlengiwe Nyilana, Senzo Hlathi, Radhamoney Narasimmulu, Ying Kuen K. Cheung, K. Rivet Amico, Gerald Friedland, Amrita Daftary, Jennifer R. Zelnick, Kogieleum Naidoo, and Max R. O’Donnell
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Tuberculosis ,MDR-TB ,HIV/AIDS ,Bedaquiline ,Antiretrovirals ,mHealth ,Medicine (General) ,R5-920 - Abstract
Abstract Background Highly effective, short-course, bedaquiline-containing treatment regimens for multidrug-resistant tuberculosis (MDR-TB) and integrase strand transfer inhibitor (INSTI)-containing fixed dose combination antiretroviral therapy (ART) have radically transformed treatment for MDR-TB and HIV. However, without advances in adherence support, we may not realize the full potential of these therapeutics. The primary objective of this study is to compare the effect of adherence support interventions on clinical and biological endpoints using an adaptive randomized platform. Methods This is a prospective, adaptive, randomized controlled trial comparing the effectiveness of four adherence support strategies on a composite clinical outcome in adults with MDR-TB and HIV initiating bedaquiline-containing MDR-TB treatment regimens and receiving ART in KwaZulu-Natal, South Africa. Trial arms include (1) enhanced standard of care, (2) psychosocial support, (3) mHealth using cellular-enabled electronic dose monitoring, and (4) combined mHealth and psychosocial support. The level of support will be titrated using a differentiated service delivery (DSD)-informed assessment of treatment support needs. The composite primary outcome will include survival, negative TB culture, retention in care, and undetectable HIV viral load at month 12. Secondary outcomes will include individual components of the primary outcome and quantitative evaluation of adherence on TB and HIV treatment outcomes. Discussion This trial will evaluate the contribution of different modes of adherence support on MDR-TB and HIV outcomes with WHO-recommended all-oral MDR-TB regimens and ART in a high-burden operational setting. We will also assess the utility of a DSD framework to pragmatically adjust levels of MDR-TB and HIV treatment support. Trial registration ClinicalTrials.gov NCT05633056. Registered on 1 December 2022
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- 2023
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47. High resolution seafloor thermometry for internal wave and upwelling monitoring using Distributed Acoustic Sensing
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Julián David Pelaez Quiñones, Anthony Sladen, Aurelien Ponte, Itzhak Lior, Jean-Paul Ampuero, Diane Rivet, Samuel Meulé, Frédéric Bouchette, Ivane Pairaud, and Paschal Coyle
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Medicine ,Science - Abstract
Abstract Temperature is an essential oceanographic variable (EOV) that still today remains coarsely resolved below the surface and near the seafloor. Here, we gather evidence to confirm that Distributed Acoustic Sensing (DAS) technology can convert tens of kilometer-long seafloor fiber-optic telecommunication cables into dense arrays of temperature anomaly sensors having millikelvin (mK) sensitivity, thus allowing to monitor oceanic processes such as internal waves and upwelling with unprecedented detail. Notably, we report high-resolution observations of highly coherent near-inertial and super-inertial internal waves in the NW Mediterranean sea, offshore of Toulon, France, having spatial extents of a few kilometers and producing maximum thermal anomalies of more than 5 K at maximum absolute rates of more than 1 K/h. We validate our observations with in-situ oceanographic sensors and an alternative optical fiber sensing technology. Currently, DAS only provides temperature changes estimates, however practical solutions are outlined to obtain continuous absolute temperature measurements with DAS at the seafloor. Our observations grant key advantages to DAS over established temperature sensors, showing its transformative potential for the description of seafloor temperature fluctuations over an extended range of spatial and temporal scales, as well as for the understanding of the evolution of the ocean in a broad sense (e.g. physical and ecological). Diverse ocean-oriented fields could benefit from the potential applications of this fast-developing technology.
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- 2023
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48. Towards a better consideration of rainfall and hydrological spatial features by a deep neural network model to improve flash floods forecasting: case study on the Gardon basin, France
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Saint-Fleur, Bob E., Allier, Sam, Lassara, Emilien, Rivet, Antoine, Artigue, Guillaume, Pistre, Séverin, and Johannet, Anne
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- 2023
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49. Missed Opportunities When We Focus only on Risk: Using the Concerns Based Conversation Starter to Identify Potential PrEP Candidates
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Johnson, Megan Mueller, Brooks, Noah, and Amico, K Rivet
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- 2023
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50. Bornological quantum groups as locally compact quantum groups
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Rivet, Damien and Yuncken, Robert
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Mathematics - Quantum Algebra ,Mathematics - Operator Algebras - Abstract
Bornological quantum groups were introduced by Voigt in order to generalize the theory of algebraic quantum groups in the sense of van Daele. In particular the class of bornological quantum groups contains all classical locally compact groups. In this paper we prove that a bornological quantum group gives rise to a locally compact quantum group, in a similar way to Kustermans and van Daele's result for algebraic quantum groups. We show that the bornological quantum groups, although more general than the algebraic ones, share most of their nice properties. We also argue that bornological quantum groups, when they occur as dense subalgebras of locally compact quantum groups, are useful tools for studying locally compact quantum groups. For instance, we show that the simple definition of a bornological closed quantum subgroup yields a closed subgroup of the locally compact quantum group in the sense of Vaes or Wooronowicz.
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- 2021
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