1. Refractory gastroesophageal reflux disease (GERD): A clinical, endoscopic, and histopathological perspective –a single centre cross-sectional study
- Author
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Somnath Verma, P. Padmanabhan, Bhavishya Sundar, and N. Dinakaran
- Subjects
Refractory GERD ,Heartburn ,Regurgitation ,Endoscopy ,Esophagus ,Barretts Esophagus ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background: Gastroesophageal reflux disease (GERD) manifests as the regurgitation of stomach contents into the esophagus, causing symptoms and potential complications. Proton Pump Inhibitors (PPIs) stand as the primary treatment, preferred for their efficacy. However, cases where patients exhibit no response or improvement following an 8-week regimen of PPIs at the recommended dosage are termed refractory GERD. In India, GERD poses a considerable strain on healthcare resources, impacting the quality of life for affected individuals. Yet, the precise prevalence and distinct manifestations of GERD in the general population remain unclear. Methods: A descriptive observational cross-sectional study was performed on patients attending the Department of Medical Gastroenterology at Meenakshi Medical College Hospital and Research Institute in Kanchipuram, Tamil Nadu, India. The study involved the examination, evaluation, and statistical correlation of the clinical symptoms, suspected risk factors, as well as histopathological and endoscopic findings in the patients. Results: Among 100 patients (average age: 39.03 ± 8.90 years, female-to-male ratio 1.7:1), regurgitation was the predominant symptom, followed by heartburn, with symptoms lasting 8 to 12 months, and a significant majority (69%) experiencing moderate to severe symptoms. Notably, regurgitation correlated significantly with waist circumference and Hill Grade (p
- Published
- 2024
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