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The Salittu Formation is one of the few metavolcanic successions in the U-Pb zircon single grain dating using the LA-MC-ICP-MS technique was utilized to determine the age of the host rocks of the Juomasuo Au-Co-Cu deposit located in the late Archean Kuusamo supracrustal belt. Even though the dated samples have diverse geochemical signatures that imply felsic volcanic and sedimentary precursors, the U-Pb data revealed heterogeneous detrital zircon populations for all samples. The host rocks are thus considered to belong to reworked sedimentary/volcano-sedimentary sequences. The maximun depositional ages of the samples fall in the 2.75-2.65 Ga age window, and no Paleoproterozoic ages were recovered in the examined zircon grains (151 analytical spots in total). In addition, a younger population (2.65-2.60 Ga) of internally featureless, BSE-pale/CL-dark zircon and zircon domains, was found in the mineralized sequences. These homogenized zircon grains resemble zircon formed in postmagmatic solid-state processes, in which zircon is recrystallized in metamorphic-hydrothermal conditions. This metamorphic-hydrothermal event most probably occurred in the original provenance area of the metasedimentary rocks.

Purpose: This study aims to analyse student and teaching staff views on how higher education (HE) can contribute to sustainable development, and to provide examples of how a medical university has adopted the sustainable development goals (SDGs) as part of its institutional strategies and practises. Design/methodology/approach: The study is based on participant views from a conference, which aimed to identify actions needed for HE to contribute to the SDGs. More than 500 students, teachers and academic leaders participated at workshops to discuss and reflect on the role of higher education institutions (HEIs) in sustainable development. The discussion key points were recorded on flipcharts, and the analysis builds on all written statements from the nine workshops. Based on the findings from the workshop, steering documents and activities of a medical university were identified as examples of implementation. Findings: Two overarching interdependent themes were identified and indicated a need to rethink the role not only of HE per se but also that of HEIs at large, to meet the challenges of sustainable development. The study also provides an example of how such organizational change can be practically implemented at a medical university, through the establishment of overarching institutional strategies, funding opportunities and external collaborations. Practical implications: The findings reflect a "bottom-up" call from students and educational staff for HEIs to step up and contribute to systems change - both through a change in pedagogies, as well as through an institution-wide approach and a shift in the role of HEIs in society. Originality/value: The study is unique in providing an exemplar of the implementation of sustainable development in HE at a specific medical university.

Abstract Mortality in renal cell cancer (RCC) is high in the elderly population. Comorbidities have a greater impact on overall prognosis of RCC among elderly patients than in younger patients. All new RCC cases were collected in people over 74 years of age between 1995 and 2018 from the Finnish cancer registry. The comorbidities were identified from the Care Registry for Healthcare. Charlson Comorbidity Index (CCI) was used to evaluate the risk of death based on comorbidities. The overall risk of death was analyzed using the Cox regression model. The risk for RCC death was analyzed using Fine and Gray regression analysis. Individual prognostic role of CCI components was evaluated by adding each component separately into the multivariable Fine and Gray regression model. Using the most prognostic comorbidities we constructed a nomogram to predict RCC mortality. Statistically significant prognostic factors of RCC death were tumor morphology (clear cell, papillary and chromophobe), sex, operative treatment, age, primary tumor extent and CCI. The strongest prognostic factors for overall mortality were tumor extent, tumor morphology and operative treatment. Among the components of CCI, the most important comorbidities predicting mortality were dementia, heart failure and kidney disease. The limitation of this study is that the comorbidities have only been recorded at inpatient and outpatient hospital contacts, which is why the prevalence of comorbidities is probably underestimated. In addition, physical performance status was not available from registry data, but it significantly affects the treatment decisions. RCC mortality is high in the elderly population. Among comorbidities, dementia and heart failure have the greatest impact on the prognosis. Curative treatment in selected elderly patients is efficient and should be considered in patients who can tolerate it and have only limited comorbidities.

Objective: This study aimed to assess perceptions and actions taken by Finnish dental professionals in suspected cases of child physical abuse (CPA) and to describe changes over 10 years. Material and methods: Data collected from two child abuse and neglect (CAN) surveys among Finnish dental professionals, working in public health care, covering suspicions of CPA and actions taken as well as training on CPA issues, were compared. The chi-squared (χ2) test was used to analyze associations. Results: In total, 625 (2008) and 1,025 (2019) questionnaires were completed. Respondents reported that they suspected CPA more frequently in 2008 than in 2019 (21.0% vs. 8.7%, p

In the formerly glaciated terrains in the northern hemisphere and countries such as Finland, till is the most common sediment covering the bedrock. Specifically, indicator or heavy mineral studies utilising till as a vector for mineral deposits undercover have been successful. The pyrite trace-element composition from in situ mineral analyses has been shown to be an effective discriminator between different mineral deposit types, and this has led to research using heavy mineral pyrite in till to identify potential mineral deposits in a given area. However, pyrite is easily oxidised in till beds, and thus, alternative methods should be considered. Goethite pseudomorphs are more commonly found in the till sediments as remnants after pyrite oxidation. This study evaluates trace element compositions of goethitised pyrite recovered in the till beds from central Lapland in northern Finland. Intra-grain trace-elemental variations gathered using laser-ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) between the intact pyrite core and oxidised rim demonstrated complex dynamics and variations between different trace-element values. For example, Cu, V and Mn exhibited elevated trace-element values in the goethite rim compared to the pyrite core. However, elemental ratios such as Ni/As and Co/Ni remain stable between the pyrite core and oxidised rim. Therefore, these ratios have the potential to be used as a discriminating tool between the pyrite core and oxidised rim. In addition, nanoscale variabilities using focused ion beam (FIB) and transmission electron microscopy (TEM) were utilised to inspect possible nano inclusions within the studied heavy mineral grain. The FIB and TEM studies revealed a nanocrystalline pyrite nodule observation within the goethite rim.

For the last two decades, Finnish universities have faced the implementation of new systems of control and undergone dramatic changes that have worsened academic working conditions -- such as corporatisation and budget cuts. This article explores Finnish academics' experiences of university reforms with a special focus on the consequences it has had in terms of organisational socio-dynamics. We adapt Glynos and Howarth's logics of critical explanation and apply this theoretical framework to analyse the interviews of academics who, against their own will, did not have their contracts renewed. This approach describes, explains, and criticises the logics -- which are social, political and fantasmatic -- behind the existence, continuation, and transformation of practices that are very real. Our research findings suggest that there are situations in which experiences of opaque management may occur at university. Academics often found the decision-making processes to be unpredictable and ambiguous, leading to a precarious working atmosphere. Combining the logics approach with micro-level data analysis, we developed the concept of arbitrary management, offering new perspectives for understanding the mediation between social practices and structural reforms. This micro-political analysis provides a new take on how ideologies operate at university in an era of academic capitalism.

The study presented in this article is part of a larger study called Progressive Feedback (blogs.helsinki.fi/orientate), which is an early childhood education and care (ECEC) research and development project. The aim of this article is to find out: (1) how children's tested creative thinking abilities, fluency, originality and imagination correlated with children's social orientations in kindergarten; and (2) how children's participative orientations occur in relation with the teacher and peers. The data consist of Reunamo's child interview tool and the Thinking Creatively in Action and Movement (TCAM) test. The data (280 children from 23 kindergartens and pre-primary schools) were gathered from two municipalities in southern Finland. The results show that the participative orientation was strongly connected with creative thinking abilities, but it was rare in social situations concerning adults. In participative orientation, children concern the situation and intend to change it.

In the original version of this Article, Supplementary Table 10 contained incorrect primer sequences for the mobility shift assay for SNP rs4776984. These errors have now been fixed and the corrected version of the Supplementary Information PDF is available to download from the HTML version of the Article.

Increased adiposity is a hallmark of obesity and overweight, which affect 2.2 billion people world-wide. Understanding the genetic and molecular mechanisms that underlie obesity-related phenotypes can help to improve treatment options and drug development. Here we perform promoter Capture Hi-C in human adipocytes to investigate interactions between gene promoters and distal elements as a transcription-regulating mechanism contributing to these phenotypes. We find that promoter-interacting elements in human adipocytes are enriched for adipose-related transcription factor motifs, such as PPARG and CEBPB, and contribute to heritability of cis-regulated gene expression. We further intersect these data with published genome-wide association studies for BMI and BMI-related metabolic traits to identify the genes that are under genetic cis regulation in human adipocytes via chromosomal interactions. This integrative genomics approach identifies four cis-eQTL-eGene relationships associated with BMI or obesity-related traits, including rs4776984 and MAP2K5, which we further confirm by EMSA, and highlights 38 additional candidate genes.

Despite major progress in defining the genetic basis of Mendelian disorders, the molecular etiology of many cases remains unknown. Patients with these undiagnosed disorders often have complex presentations and require treatment by multiple health care specialists. Here, we describe an integrated clinical diagnostic and research program using whole-exome and whole-genome sequencing (WES/WGS) for Mendelian disease gene discovery. This program employs specific case ascertainment parameters, a WES/WGS computational analysis pipeline that is optimized for Mendelian disease gene discovery with variant callers tuned to specific inheritance modes, an interdisciplinary crowdsourcing strategy for genomic sequence analysis, matchmaking for additional cases, and integration of the findings regarding gene causality with the clinical management plan. The interdisciplinary gene discovery team includes clinical, computational, and experimental biomedical specialists who interact to identify the genetic etiology of the disease, and when so warranted, to devise improved or novel treatments for affected patients. This program effectively integrates the clinical and research missions of an academic medical center and affords both diagnostic and therapeutic options for patients suffering from genetic disease. It may therefore be germane to other academic medical institutions engaged in implementing genomic medicine programs.

Background and aimsHypercholesterolemia confers susceptibility to cardiovascular disease (CVD). Both serum total cholesterol (TC) and LDL-cholesterol (LDL-C) exhibit a strong genetic component (heritability estimates 0.41-0.50). However, a large part of this heritability cannot be explained by the variants identified in recent extensive genome-wide association studies (GWAS) on lipids. Our aim was to find genetic causes leading to high LDL-C levels and ultimately CVD in a large Austrian family presenting with what appears to be autosomal dominant inheritance for familial hypercholesterolemia (FH).MethodsWe utilized linkage analysis followed by whole-exome sequencing and genetic risk score analysis using an Austrian multi-generational family with various dyslipidemias, including elevated TC and LDL-C, and one family branch with elevated lipoprotein (a) (Lp(a)).ResultsWe did not find evidence for genome-wide significant linkage for LDL-C or apparent causative variants in the known FH genes rather, we discovered a particular family-specific combination of nine GWAS LDL-C SNPs (p = 0.02 by permutation), and putative less severe familial hypercholesterolemia mutations in the LDLR and APOB genes in a subset of the affected family members. Separately, high Lp(a) levels observed in one branch of the family were explained primarily by the LPA locus, including short (

ObjectiveWe recently identified a locus on chromosome 18q11.2 for high serum triglycerides in Mexicans. We hypothesize that the lead genome-wide association study single-nucleotide polymorphism rs9949617, or its linkage disequilibrium proxies, regulates 1 of the 5 genes in the triglyceride-associated region.Approach and resultsWe performed a linkage disequilibrium analysis and found 9 additional variants in linkage disequilibrium (r(2)>0.7) with the lead single-nucleotide polymorphism. To select the variants for functional analyses, we annotated the 10 variants using DNase I hypersensitive sites, transcription factor and chromatin states and identified rs17259126 as the lead candidate variant for functional in vitro validation. Using luciferase transcriptional reporter assay in liver HepG2 cells, we found that the G allele exhibits a significantly lower effect on transcription (P

Many genetic variants influence complex traits by modulating gene expression, thus altering the abundance of one or multiple proteins. Here we introduce a powerful strategy that integrates gene expression measurements with summary association statistics from large-scale genome-wide association studies (GWAS) to identify genes whose cis-regulated expression is associated with complex traits. We leverage expression imputation from genetic data to perform a transcriptome-wide association study (TWAS) to identify significant expression-trait associations. We applied our approaches to expression data from blood and adipose tissue measured in ∼ 3,000 individuals overall. We imputed gene expression into GWAS data from over 900,000 phenotype measurements to identify 69 new genes significantly associated with obesity-related traits (BMI, lipids and height). Many of these genes are associated with relevant phenotypes in the Hybrid Mouse Diversity Panel. Our results showcase the power of integrating genotype, gene expression and phenotype to gain insights into the genetic basis of complex traits.

Abstract A pedigree of subjects presented with frontonasal dysplasia (FND). Genome sequencing and analysis identified a p.L165F missense variant in the homeodomain of the transcription factor ALX1 which was imputed to be pathogenic. Induced pluripotent stem cells (iPSC) were derived from the subjects and differentiated to neural crest cells (NCC). NCC derived from ALX1L165F/L165F iPSC were more sensitive to apoptosis, showed an elevated expression of several neural crest progenitor state markers, and exhibited impaired migration compared to wild‐type controls. NCC migration was evaluated in vivo using lineage tracing in a zebrafish model, which revealed defective migration of the anterior NCC stream that contributes to the median portion of the anterior neurocranium, phenocopying the clinical presentation. Analysis of human NCC culture media revealed a change in the level of bone morphogenic proteins (BMP), with a low level of BMP2 and a high level of BMP9. Soluble BMP2 and BMP9 antagonist treatments were able to rescue the defective migration phenotype. Taken together, these results demonstrate a mechanistic requirement of ALX1 in NCC development and migration.

The purpose of this article is to study children’s social orientations as creative processes in early childhood education and care (ECEC). In this article, we focus on how children’s creative thinking abilities relate to children’s social orientations in interactive situations in ECEC. We study children’s creative thinking abilities with the Thinking Creatively in Action and Movement [TCAM] -test and children’s social orientations with the Child observation instrument of Reunamo (2007). Two hundred and eighty children in 23 ECEC institutions participated in the research. There were altogether eight randomly selected days for the observation between January and May 2015. The TCAM-test was conducted by teachers for their own group. The connections between the TCAM-test and the Child observation instrument were studied with partial correlations controlling children’s age. The results showed that children’s creative thinking abilities were associated positively with participative social orientation. An adaptive and withdrawn orientation had negative correlations with creative thinking abilities.

Only 3–5% of heavy alcohol users develop acute alcohol pancreatitis (AAP). This suggests that additional triggers are required to initiate the inflammatory process. Genetic susceptibility contributes to the development of AAP, and SPINK1 mutation is a documented risk factor. We investigated the prevalence of the SPINK1(N34S) mutation in patients with AAP compared to heavy alcohol users who had never suffered an episode of pancreatitis. Blood samples for the mutational analysis from patients with first episode (n = 60) and recurrent AAP (n = 43) and from heavy alcohol users without a history of AAP (n = 98) as well as from a control population (n = 1914) were obtained. SPINK1 mutation was found in 8.7% of the patients with AAP. The prevalence was significantly lower in healthy controls (3.4%, OR 2.72; 1.32–5.64) and very low in alcoholics without pancreatitis (1.0%, OR 9.29; 1.15–74.74). In a comparison adjusted for potential cofounders between AAP patients and alcoholics, SPINK1 was found to be an independent marker for AAP. The prevalence of the SPINK1 mutation is overrepresented in AAP patients and very low in alcoholics without pancreatitis. This finding may play a role in understanding the variable susceptibility to AAP found in heavy alcohol users.

Background and purposeRemote ischemic conditioning (RIC) is a phenomenon in which short periods of nonfatal ischemia in 1 tissue confers protection to distant tissues. Here we performed a longitudinal human pilot study in patients with aneurysmal subarachnoid hemorrhage undergoing RIC by limb ischemia to compare changes in DNA methylation and transcriptome profiles before and after RIC.MethodsThirteen patients underwent 4 RIC sessions over 2 to 12 days after rupture of an intracranial aneurysm. We analyzed whole blood transcriptomes using RNA sequencing and genome-wide DNA methylomes using reduced representation bisulfite sequencing, both before and after RIC. We tested differential expression and differential methylation using an intraindividual paired study design and then overlapped the differential expression and differential methylation results for analyses of functional categories and protein-protein interactions.ResultsWe observed 164 differential expression genes and 3493 differential methylation CpG sites after RIC, of which 204 CpG sites overlapped with 103 genes, enriched for pathways of cell cycle (P

In this article we examine first-year student teachers' possibilities to become interested in professional issues in teacher education. We study the phenomenon of becoming interested among first-year student teachers via three different kinds of data. We analysed our data through John Dewey's definition of interest, where a person has an interest if s/he is actively keen on some object that has personal meaning for her/him. According to our data, student teachers adopt an object of interest that teacher educators provide. Learners found it difficult to find the objects of interests by themselves, and it was exceptional for them to find personal meaning and an active state of interest. This is problematic because studying may be performance-oriented without the conditions of interest conceptualised by Dewey. Through our study we also discuss a theoretical approach which would help understand the mechanism behind becoming interested.

Dyslipidemia and obesity are especially prevalent in populations with Amerindian backgrounds, such as Mexican-Americans, which predispose these populations to cardiovascular disease. Here we design an approach, known as the cross-population allele screen (CPAS), which we conduct prior to a genome-wide association study (GWAS) in 19,273 Europeans and Mexicans, in order to identify Amerindian risk genes in Mexicans. Utilizing CPAS to restrict the GWAS input variants to only those differing in frequency between the two populations, we identify novel Amerindian lipid genes, receptor-related orphan receptor alpha (RORA) and salt-inducible kinase 3 (SIK3), and three loci previously unassociated with dyslipidemia or obesity. We also detect lipoprotein lipase (LPL) and apolipoprotein A5 (APOA5) harbouring specific Amerindian signatures of risk variants and haplotypes. Notably, we observe that SIK3 and one novel lipid locus underwent positive selection in Mexicans. Furthermore, after a high-fat meal, the SIK3 risk variant carriers display high triglyceride levels. These findings suggest that Amerindian-specific genetic architecture leads to a higher incidence of dyslipidemia and obesity in modern Mexicans.

Context: In Lebanon, older adults face socioeconomic challenges that are expected to worsen due to an increase in older adult population, chronic governmental neglect, institutionalised ageism and a lack of educational and social gerontologists. Consequently, local older adults are in dire need for social change, which can be initiated through later life learning. The University for Seniors (UfS) is a University for the Third Age providing learning opportunities for older people in Lebanon. While most older adult learning programmes are occupied with their learners' self-fulfilment, Critical Educational Gerontology promotes emancipatory learning and social change. Study Objective and Design: A case discussion based on a variety of data sources is used to showcase and then challenge the practices of UfS from a critical educational gerontology perspective. To do that, we consider the semantic difference between emancipation and empowerment in their relation to power. Recommendations: We recommend programme-specific measures starting by revisiting the current philosophy of learning, targeting social change as an additional goal to later life learning, and advocacy for the establishment of educational degrees to prepare professionals and academicians in the field of social gerontology. We also recommend a more critical use of empowerment and emancipation within critical educational gerontology.

Abstract Background High serum triglyceride (TG) levels is an established risk factor for coronary heart disease (CHD). Fat is stored in the form of TGs in human adipose tissue. We hypothesized that gene co-expression networks in human adipose tissue may be correlated with serum TG levels and help reveal novel genes involved in TG regulation. Methods Gene co-expression networks were constructed from two Finnish and one Mexican study sample using the blockwiseModules R function in Weighted Gene Co-expression Network Analysis (WGCNA). Overlap between TG-associated networks from each of the three study samples were calculated using a Fisher’s Exact test. Gene ontology was used to determine known pathways enriched in each TG-associated network. Results We measured gene expression in adipose samples from two Finnish and one Mexican study sample. In each study sample, we observed a gene co-expression network that was significantly associated with serum TG levels. The TG modules observed in Finns and Mexicans significantly overlapped and shared 34 genes. Seven of the 34 genes (ARHGAP30, CCR1, CXCL16, FERMT3, HCST, RNASET2, SELPG) were identified as the key hub genes of all three TG modules. Furthermore, two of the 34 genes (ARHGAP9, LST1) reside in previous TG GWAS regions, suggesting them as the regional candidates underlying the GWAS signals. Conclusions This study presents a novel adipose gene co-expression network with 34 genes significantly correlated with serum TG across populations.

Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder with poorly understood pathophysiology and genetic mechanisms. A balanced chromosomal translocation interrupts CTNND2 in several members of a family with profound attentional deficit and myopia, and disruption of the gene was found in a separate unrelated individual with ADHD and myopia. CTNND2 encodes a brain-specific member of the adherens junction complex essential for postsynaptic and dendritic development, a site of potential pathophysiology in attentional disorders. Therefore, we propose that the severe and highly penetrant nature of the ADHD phenotype in affected individuals identifies CTNND2 as a potential gateway to ADHD pathophysiology similar to the DISC1 translocation in psychosis or AUTS2 in autism.

Artikkelimme käsittelee keskijohdon asemaa tietotyön, tässä tapauksessa yliopistotyön, organisoinnissa. Tutkimuksen empiria perustuu haastatteluaineistoon, joka on osa laajempaa etnografista aineistoa. Kuvaamme haastatteluaineiston kautta erästä työyhteisöä tapausesimerkkinä käyttäen millaisia positioita, puhe­tapoja ja artikulaatiota keskijohdon kaksoisasema organisaatiossa heille tuottaa sekä oman että alaisten työn johtamisessa. Kysymme erityisesti: 1) Miten keskijohdon edustajat hahmottavat epävarmuuden osana organisaation toimintaa, omaa työtään ja alaisten työn organisointia? 2) Miten epävarmuuteen keskijohdon positiosta suhtaudutaan ja millaisia mahdollisia ristiriitatilanteita tämä tuottaa koko organisaation toimintaan? Analyysissa hyödynnämme erityisesti kaksoisroolin ja kaksoissidoksen käsitteitä. Tuloksena kuvaamme, miten keskijohdon kaksoisasemasta seuraa työn organisointiin epäselvyyttä, joka ilmenee keskijohdon puheessa kaksoissidoksina. Tutkimuksemme on tapausesimerkki siitä, millaisena keskijohdon asema näyttäytyy nykyisissä johtamisen tavoissa. Tulosten yhteys tietotyön sekä erityisesti yliopistoissa viimeisen vuosikymmen aikana tapahtuneisiin organisaatio­ ja johtamistapojen muutoksiin vaatii lisätutkimusta.

In this research, children's creativity in pretend play and the conditions for creativity during high involvement are studied from four points of view: as a zone for proximal development, as a skill, as a personal orientation and as a culturally shared environment creation. The theoretical model is influenced by Vygotsky's ideas of creativity as cultural mediation. The research methods are systematic observation and skill evaluation. The participants are 280 Finnish four- to five-year-old children in day care. The results highlight the importance of play both by sheer volume and also by children's involvement in it. Children's internalised skills result in personal choices and a personal network of peer contacts. The different choices result in different creative culture production environments. Creative children attract each other and they meet in creative social processes. However, less creative children get excluded from the creative core. Thus, children who need creative scaffolding the most get it the least. The possibilities of involving children in creative processes are discussed.

Ahonen, Sirkka: Suomalaisuuden monet myytit. Kansallinen katse historian kirjoissa. Gaudeamus, Tallinna 2017. 247 s.

Kalle Kinnunen (toimittaja): Kone-Suomi. Khaos Publishing, Helsinki 2017. 319 s.

Supported cellulose ultrafiltration membranes are cast from a cellulose-ionic liquid solution by the immersion precipitation technique. The effects of coagulation bath temperature and polymer concentration in the casting solution on the membrane morphology, wettability, pure water flux, molecular weight cut-off, and fouling resistance are studied. Scanning electron microscopy, contact angle measurements, atomic force microscopy, and filtration experiments are carried out in order to characterise the obtained ultrafiltration cellulose membranes. The results show the effect of coagulation bath temperature and polymer concentration on the surface morphology and properties of cellulose ultrafiltration membranes. Optimisation of the two parameters leads to the creation of dense membranes with good pure water fluxes and proven fouling resistance towards humic acid water solutions.