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2. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry
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Jitendra PS. Sawhney, Veerappa A. Kothiwale, Vikas Bisne, Rajashekhar Durgaprasad, Praveen Jadhav, Manoj Chopda, Velam Vanajakshamma, Ramdhan Meena, Govindan Vijayaraghavan, Kamaldeep Chawla, Jagan Allu, Karen S. Pieper, A. John Camm, Ajay K. Kakkar, Jean-Pierre Bassand, David A. Fitzmaurice, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Alexander G.G. Turpie, Martin van Eickels, Freek W.A. Verheugt, Gloria Kayani, Keith A.A. Fox, Bernard J. Gersh, Hector Lucas Luciardi, Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, Alex Spyropoulos, John Eikelboom, Ramon Corbalan, Dayi Hu, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean-Yves Le Heuzey, Harald Darius, Matyas Keltai, Sanjay Kakkar, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, D.Y. Hu, K.N. Chen, Y.S. Zhao, H.Q. Zhang, J.Z. Chen, S.P. Cao, D.W. Wang, Y.J. Yang, W.H. Li, Y.H. Yin, G.Z. Tao, P. Yang, Y.M. Chen, S.H. He, Ying Wang, Yong Wang, G.S. Fu, X. Li, T.G. Wu, X.S. Cheng, X.W. Yan, R.P. Zhao, M.S. Chen, L.G. Xiong, P. Chen, Y. Jiao, Y. Guo, L. Xue, F.Z. Wang, H. Li, Z.M. Yang, C.L. Bai, J. Chen, J.Y. Chen, X. Chen, S. Feng, Q.H. Fu, X.J. Gao, W.N. Guo, R.H. He, X.A. He, X.S. Hu, X.F. Huang, B. Li, J. Li, L. Li, Y.H. Li, T.T. Liu, W.L. Liu, Y.Y. Liu, Z.C. Lu, X.L. Luo, T.Y. Ma, J.Q. Peng, X. Sheng, X.J. Shi, Y.H. Sun, G. Tian, K. Wang, L. Wang, R.N. Wu, Q. Xie, R.Y. Xu, J.S. Yang, L.L. Yang, Q. Yang, Y. Ye, H.Y. Yu, J.H. Yu, T. Yu, H. Zhai, Q. Zhan, G.S. Zhang, Q. Zhang, R. Zhang, Y. Zhang, W.Y. Zheng, B. Zhou, Z.H. Zhou, X.Y. Zhu, S. Kakkar, J.P.S. Sawhney, P. Jadhav, R. Durgaprasad, A.G. Ravi Shankar, R.K. Rajput, K. Bhargava, R. Sarma, A. Srinivas, D. Roy, U.M. Nagamalesh, M. Chopda, R. Kishore, G. Kulkarni, P. Chandwani, R.A. Pothiwala, M. Padinhare Purayil, S. Shah, K. Chawla, V.A. Kothiwale, B. Raghuraman, G. Vijayaraghavan, V.M. Vijan, G. Bantwal, V. Bisne, A. Khan, J.B. Gupta, S. Kumar, D. Jain, S. Abraham, D. Adak, A. Barai, H. Begum, P. Bhattacharjee, M. Dargude, D. Davies, B. Deshpande, P. Dhakrao, V. Dhyani, S. Duhan, M. Earath, A. Ganatra, S. Giradkar, V. Jain, R. Karthikeyan, L. Kasala, S. Kaur, S. Krishnappa, A. Lawande, B. Lokesh, N. Madarkar, R. Meena, P. More, D. Naik, K. Prashanth, M. Rao, N.M. Rao, N. Sadhu, D. Shah, M. Sharma, P. Shiva, S. Singhal, S. Suresh, V. Vanajakshamma, S.G. Panse, Y. Koretsune, S. Kanamori, K. Yamamoto, K. Kumagai, Y. Katsuda, K. Sadamatsu, F. Toyota, Y. Mizuno, I. Misumi, H. Noguchi, S. Ando, T. Suetsugu, M. Minamoto, Hiroshi Oda, K. Shiraishi, S. Adachi, K. Chiba, H. Norita, M. Tsuruta, T. Koyanagi, H. Ando, T. Higashi, K. Okada, S. Azakami, S. Komaki, K. Kumeda, T. Murayama, J. Matsumura, Y. Oba, R. Sonoda, K. Goto, K. Minoda, Y. Haraguchi, H. Suefuji, H. Miyagi, H. Kato, Tadashi Nakamura, Tsugihiro Nakamura, H. Nandate, R. Zaitsu, Yoshihisa Fujiura, A. Yoshimura, H. Numata, J. Ogawa, H. Tatematsu, Y. Kamogawa, K. Murakami, Y. Wakasa, M. Yamasawa, H. Maekawa, S. Abe, H. Kihara, S. Tsunoda, Katsumi Saito, Kazuyuki Saito, T. Fudo, K. Obunai, H. Tachibana, I. Oba, T. Kuwahata, S. Higa, M. Gushiken, T. Eto, H. Yoshida, D. Ikeda, Yoshitake Fujiura, M. Ishizawa, M. Nakatsuka, K. Murata, C. Ogurusu, M. Shimoyama, M. Akutsu, I. Takamura, F. Hoshino, N. Yokota, T. Iwao, K. Tsuchida, M. Takeuchi, Y. Hatori, Y. Kitami, Yoichi Nakamura, R. Oyama, M. Ageta, Hiroyuki Oda, Y. Go, K. Mishima, T. Unoki, S. Morii, Yuhei Shiga, H. Sumi, T. Nagatomo, K. Sanno, K. Fujisawa, Y. Atsuchi, T. Nagoshi, T. Seto, T. Tabuchi, M. Kameko, K. Nii, K. Oshiro, H. Takezawa, S. Nagano, N. Miyamoto, M. Iwaki, Yuichiro Nakamura, M. Fujii, M. Okawa, Masahiko Abe, Masatake Abe, Mitsunori Abe, T. Saito, T. Mito, K. Nagao, J. Minami, T. Mita, I. Sakuma, T. Taguchi, S. Marusaki, H. Doi, M. Tanaka, T. Fujito, M. Matsuta, T. Kusumoto, S. Kakinoki, K. Ashida, N. Yoshizawa, J. Agata, O. Arasaki, M. Manita, M. Ikemura, S. Fukuoka, H. Murakami, S. Matsukawa, Y. Hata, T. Taniguchi, T. Ko, H. Kubo, M. Imamaki, M. Akiyama, M. Inagaki, H. Odakura, T. Ueda, Y. Katsube, A. Nakata, H. Watanabe, M. Techigawara, M. Igarashi, K. Taga, T. Kimura, S. Tomimoto, M. Shibuya, M. Nakano, K. Ito, T. Seo, S. Hiramitsu, H. Hosokawa, M. Hoshiai, M. Hibino, K. Miyagawa, Hajime Horie, N. Sugishita, Yukio Shiga, A. Soma, K. Neya, Tetsuro Yoshida, Tomoki Yoshida, M. Mizuguchi, M. Ishiguro, T. Minagawa, M. Wada, H. Mukawa, F. Okuda, S. Nagasaka, Y. Abe, Sen Adachi, Susumu Adachi, T. Adachi, K. Akahane, T. Amano, K. Aoki, T. Aoyama, H. Arai, S. Arima, T. Arino, H. Asano, T. Asano, J. Azuma, T. Baba, T. Betsuyaku, H. Chibana, H. Date, J. Doiuchi, Y. Emura, M. Endo, Y. Fujii, R. Fujiki, A. Fujisawa, Y. Fujisawa, T. Fukuda, T. Fukui, N. Furukawa, T. Furukawa, W. Furumoto, T. Goto, M. Hamaoka, N. Hanazono, K. Hasegawa, T. Hatsuno, Y. Hayashi, K. Higuchi, K. Hirasawa, H. Hirayama, M. Hirose, S. Hirota, M. Honda, Hideki Horie, T. Ido, O. Iiji, H. Ikeda, K. Ikeda, K. Ikeoka, M. Imaizumi, H. Inaba, T. Inoue, F. Iseki, A. Ishihara, N. Ishioka, N. Ito, T. Iwase, H. Kakuda, J. Kamata, H. Kanai, H. Kanda, M. Kaneko, H. Kano, T. Kasai, T. Kato, Y. Kato, Y. Kawada, K. Kawai, K. Kawakami, S. Kawakami, T. Kawamoto, S. Kawano, J. Kim, T. Kira, H. Kitazawa, H. Kitazumi, T. Kito, T. Kobayashi, T. Koeda, J. Kojima, H. Komatsu, I. Komatsu, Y. Koshibu, T. Kotani, T. Kozuka, Y. Kumai, T. Kumazaki, I. Maeda, K. Maeda, Y. Maruyama, S. Matsui, K. Matsushita, Y. Matsuura, K. Mineoi, H. Mitsuhashi, N. Miura, S. Miyaguchi, S. Miyajima, H. Miyamoto, A. Miyashita, S. Miyata, I. Mizuguchi, A. Mizuno, T. Mori, O. Moriai, K. Morishita, O. Murai, Sho Nagai, Shunichi Nagai, E. Nagata, H. Nagata, A. Nakagomi, S. Nakahara, M. Nakamura, R. Nakamura, N. Nakanishi, T. Nakayama, R. Nakazato, T. Nanke, J. Nariyama, Y. Niijima, H. Niinuma, Y. Nishida, Y. Nishihata, K. Nishino, H. Nishioka, K. Nishizawa, I. Niwa, K. Nomura, S. Nomura, M. Nozoe, T. Ogawa, N. Ohara, M. Okada, K. Okamoto, H. Okita, M. Okuyama, H. Ono, T. Ono, Y. Onuki Pearce, S. Oriso, A. Ota, E. Otaki, Y. Saito, H. Sakai, N. Sakamoto, Y. Sakamoto, Y. Samejima, Y. Sasagawa, H. Sasaguri, A. Sasaki, T. Sasaki, Kazuki Sato, Kiyoharu Sato, M. Sawano, S. Seki, Y. Sekine, Y. Seta, K. Sezaki, N. Shibata, Y. Shiina, H. Shimono, Y. Shimoyama, T. Shindo, H. Shinohara, R. Shinohe, T. Shinozuka, T. Shirai, T. Shiraiwa, Y. Shozawa, T. Suga, C. Sugimoto, Kazuo Suzuki, Keita Suzuki, Shu Suzuki, Shunji Suzuki, Susumu Suzuki, Y. Suzuki, M. Tada, A. Taguchi, T. Takagi, Y. Takagi, K. Takahashi, S. Takahashi, H. Takai, C. Takanaka, S. Take, H. Takeda, K. Takei, K. Takenaka, T. Tana, G. Tanabe, K. Taya, H. Teragawa, S. Tohyo, S. Toru, Y. Tsuchiya, T. Tsuji, K. Tsuzaki, H. Uchiyama, O. Ueda, Y. Ueyama, N. Wakaki, T. Wakiyama, T. Washizuka, M. Watanabe, T. Yamada, T. Yamagishi, H. Yamaguchi, Kenichi Yamamoto, Kentaro Yamamoto, Kunihiko Yamamoto, T. Yamamoto, M. Yamaura, M. Yamazoe, K. Yasui, Y. Yokoyama, K. Yoshida, T.W. Lim, C.K. Ching, C.G. Foo, J.H. Chow, D.D. Chen, F.R. Jaufeerally, Y.M. Lee, G. Lim, W.T. Lim, S. Thng, S.Y. Yap, C. Yeo, S. Oh, H.N. Pak, J.-B. Kim, J.H. Kim, S.-W. Jang, D.H. Kim, D.R. Ryu, S.W. Park, D.-K. Kim, D.J. Choi, Y.S. Oh, M.-C. Cho, S.-H. Kim, H.-K. Jeon, D.-G. Shin, J.S. Park, H.K. Park, S.-J. Han, J.H. Sung, J.-G. Cho, G.-B. Nam, Y.K. On, H.E. Lim, J.J. Kwak, T.-J. Cha, T.J. Hong, S.H. Park, J.H. Yoon, N.-H. Kim, K.-S. Kim, B.C. Jung, G.-S. Hwang, C.-J. Kim, D.B. Kim, J.J. Ahn, H.J. An, H. Bae, A.L. Baek, W.J. Chi, E.A. Choi, E.H. Choi, H.K. Choi, H.S. Choi, S. Han, E.S. Heo, K.O. Her, S.W. Hwang, E.M. Jang, H.-S. Jang, S. Jang, H.-G. Jeon, S.R. Jeon, Y.R. Jeon, H.K. Jeong, I.-A. Jung, Hyeon Jeong Kim, Hyun Ju Kim, Ji Seon Kim, Jung Sook Kim, J.A. Kim, K.T. Kim, M.S. Kim, Sang Hee Kim, Sang Hyun Kim, Y.-I. Kim, C.S. Lee, E.H. Lee, G.H. Lee, H.Y. Lee, H.-Y. Lee, K.H. Lee, K.R. Lee, M.S. Lee, M.-Y. Lee, R.W. Lee, S.E. Lee, S.H. Lee, S. Lee, W.Y. Lee, I.K. Noh, A.R. Park, B.R. Park, H.N. Park, J.H. Park, M. Park, Y. Park, S.-Y. Seo, J. Shim, J.H. Sim, Y.M. Sohn, W.S. Son, Y.S. Son, H.J. Song, H.K. Wi, J.J. Woo, S. Ye, K.H. Yim, K.M. Yoo, E.J. Yoon, S.Y. Yun, P. Angchaisuksiri, S. Chawanadelert, P. Mongkolwongroj, K. Kanokphatcharakun, S. Cheewatanakornkul, T. Laksomya, S. Pattanaprichakul, T. Chantrarat, S. Rungaramsin, S. Silaruks, W. Wongcharoen, K. Siriwattana, K. Likittanasombat, P. Katekangplu, W. Boonyapisit, D. Cholsaringkarl, B. Chatlaong, P. Chattranukulchai, Y. Santanakorn, P. Hutayanon, P. Khunrong, T. Bunyapipat, S. Jai-Aue, P. Kaewsuwanna, P. Bamungpong, S. Gunaparn, S. Hongsuppinyo, R. Inphontan, R. Khattaroek, K. Khunkong, U. Kitmapawanont, C. Kongsin, B. Naratreekoon, S. Ninwaranon, J. Phangyota, A. Phrommintikul, P. Phunpinyosak, K. Pongmorakot, S. Poomiphol, N. Pornnimitthum, S. Pumprueg, S. Ratchasikaew, K. Sanit, K. Sawanyawisuth, B. Silaruks, R. Sirichai, A. Sriwichian, W. Suebjaksing, P. Sukklad, T. Suttana, A. Tangsirira, O. Thangpet, W. Tiyanon, Y. Vorasettakarnkij, T. Wisaratapong, W. Wongtheptien, A. Wutthimanop, S. Yawila, A. Oto, A. Altun, I. Ozdogru, K. Ozdemir, O. Yilmaz, A. Aydinlar, M.B. Yilmaz, E. Yeter, Z. Ongen, M. Cayli, H. Pekdemir, M. Ozdemir, M. Sucu, T. Sayin, M. Demir, H. Yorgun, M. Ersanli, E. Okuyan, D. Aras, H. Abdelrahman, O. Aktas, D. Alpay, F. Aras, M.F. Bireciklioglu, S. Budeyri, M. Buyukpapuc, S. Caliskan, M. Esen, M.A. Felekoglu, D. Genc, B. Ikitimur, E.B. Karaayvaz, S. Kılıç Karataş, S. Okutucu, E. Ozcelik, A. Quisi, H. Sag, L. Sahiner, B.Y. Sayin, T. Seker, D. Uzun Alkan, E. Yildirim, R. Yildirim, F. Yilmaz, V. Yuksekdag, H.L. Luciardi, N. Vensentini, A.C. Ingaramo, G.A. Sambadaro, V. Fernandez Caputi, S.G. Berman, P. Dragotto, A.J. Kleiban, N. Centurion, G. Giacomi, R.A. Ahuad Guerrero, D. Conde, G. Zapata, L.A. Di Paola, J.L. Ramos, R.D. Dran, J. Egido, A.A. Fernandez, M.J. Fosco, S. Sassone, V.A. Sinisi, L.R. Cartasegna, M.A. Berli, O.A. Gomez Vilamajo, F. Ferroni, E.D. Alaguibe, A. Alvarez D'Amelio, C. Arabetti, L. Arias, J.A. Belardi, L. Bergesio, F. Berli, M. Berli, S. Borchowiec, C. Buzzetti, R. Cabrini, V. Campisi, A.L. Cappi, R. Carrizo, F. Colombo Berra, J.P. Costabel, O.J.A. Costamagna, A.A. Damonte, I.N. De Urquiza, F. Diez, M.F. Edén, M. Fanuele, F. Fernandez Voena, M. Foa Torres, C. Funosas, M.P. Giacomi, C.H. Gimenez, E.P. Gurfinkel, M. de L.M. Had, V. Hansen, A.D. Hrabar, M. Ingratta, A. Lopez, G. Maehara, L. Maffei, A. Martinelli, C. Martinelli, J. Matkovich, B. Mautner, A. Meirino, R. Munguia, A. Navarro, V. Novas, G. Perez Prados, J. Pontoriero, R.N. Potito, C. Ricotti, M.A. Rodriguez, F. Rolandi, M.E. Said Palladino, M. Salinger, L.S. Sanziani, P.O. Schygiel, A. Sossich, J.F. Tinto, L. Tonelli, A.L. Tufare, M. Vallejo, M.E. Yunis, M. Zillo, F.J. Zurbrigk, A.C.P. Barretto, D.C. Sobral Filho, J. Jaber, D. Armaganijan, J. Faria Neto, A. Steffens, W. Kunz Sebba Barroso de Souza, J.D. de Souza Neto, J.M. Ribeiro, M. Silveira Teixeira, P.R. Ferreira Rossi, L. Pires, D. Moreira, J.C. Moura Jorge, A. Menezes Lorga Filho, L.C. Bodanese, M. Westerlund Montera, C.H. Del Carlo, T. Da Rocha Rodrigues, F.A. Alves da Costa, A. Lopes, R. Lopes, G.R. Araújo, E.R. Fernandes Manenti, J.F. Kerr Saraiva, J.C. Ferreira Braga, A. Negri, L. Souto, C. Moncada, D. Bertolim Precoma, F. Roquette, G. Reis, R.A. Ramos Filho, E. Lanna Figueiredo, R. Vieira Botelho, C. Munhoz da Fontoura Tavares, C.R. Costantini Frack, J. Abdalla Saad, H.C. Finimundi, C. Pisani, D. Chemello, M. Pereira Martins, C.C. Broilo França, F. Alban, G.B. Aranha Rosito, J.B. de Moura Xavier Moraes Junior, R.T. Tumelero, L. Nigro Maia, R. Simões de Almeida, N.C. do Carmo Borges, L.G. Gomes Ferreira, P. Agliardi, J. Alves de Oliveira Gomes, V. Araujo, M. Arruda Nakazone, T. Barbosa, S. Barroso, E. Belisario Falchetto, H. Bellotti Lopes, M.A. Benez Teixeira Lemos, G. Biazus, L. Borges Queiroz, F.E. Camazzola, M. Caporale, S. Cardoso Boscato, F. Chieza, M.O. Chokr, R. Clemente Mingireanov, N. Codonho Góes, C. Correa, M. Costa, C. Costantini Ortiz, L.S. da Silva, F. da Silva Paulitsch, J.A. da Silveira, E. Daros, G.R. de Araújo, M.I. Del Monaco, C. Dias, M.A. Dias, A.P. Drummond Wainstein, P. Ely Pizzato, D.C. Esteves, P. Fabri, T. Félix Lorenzato Fonseca, E. Fernandes, C. Fonseca, C.R. Frack Costantini, R. Franchin Ferraz, F. Freire, P. Gottardo, D. Guanaes, S. Guizzardi, E. Hettwer Magedanz, F. Igansi, F. Jannuzzi, G. Junior, D. Komar, E.G. Lino, D. Lopes, O. Lourenço da Silva Júnior, E. Lustosa, A.P. Macagnan, M.C. Marinho, M. Mazzoni, G. Melo, L. Mortari, O.M.C.C. Mouco, C. Nanzer Vital, C. Ormundo, S. Oss Emmer, E. Palmegiani, R. Pavani, L. Pereira, V.L. Pereira, R. Perreira, S. Poletti, S.C. Quaia Fortunato, C. Queirantes, N. Ramos Pereira, R.L. Rech, S. Ribeiro, A. Rodrigues, H. Roesch, T. Ruaro Reichert, D. Santos, I. Santos, M. Santos, M.V. Seroqui, S. Silva, L. Soares, L. Spolaor, C. Stoll, N. Toazza Duda, L. Trama, B. Unterkircher, M.V. Valois, T. Vargas, T. Viana, C. Vicente, L. Vidal Armaganijan, R. Vieira Homem, L.G. Vieira Torres, L. Vila Boas, F. Villaça Guimarães Filho, R. Corbalan, G. Eggers, C. Bugueño Gutiérrez, G. Arriagada, S. Potthoff Cardenas, B.A.J. Stockins Fernandez, C. Conejeros, C. Houzvic, P. Marin Cuevas, H. Montecinos, A. Forero, F. Lanas, M. Larico Gómez, G. Charme Vilches, C. Rey, C. Astudillo, J. Aguilar, Y. Campisto, C. Lara, E. Molina, J. Munoz Oyarzon, V. Olguin, M. Vergara, C. Villan, C.J. Sánchez Díaz, J. Illescas Diaz, R. Leal Cantú, M.G. Ramos Zavala, R. Cabrera Jardines, N. Espinola Zavaleta, S. Villarreal Umaña, E. López Rosas, G. Llamas Esperón, G. Pozas, E. Cardona Muñoz, N. Matadamas Hernández, A. Leyva Rendón, N. García Hernández, M. de los Ríos Ibarra, L. Virgen Carrillo, D. López Villezca, C. Hernández Herrera, J.J. López Prieto, R. Gaona Rodríguez, E. Villeda Espinosa, D. Flores Martínez, J. Velasco Barcena, R. Yong, I. Rodríguez Briones, J.L. Leiva Pons, H. Álvarez López, R. Olvera Ruiz, C. Díaz de la Vega, C. Cantú Brito, E. Chuquiure Valenzuela, R. Reyes-Sanchez, A. Bazzoni Ruiz, O. Nandayapa Flores, M. Benavides Gonzalez, R. Arriaga Nava, J.D. Morales Cerda, O. Fierro Fierro, P. Fajardo Campos, T.A.A. Alfaro, S. Altamirano Bellorin, R. 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Robiro Robiro, M. Roca, C. Roca Saumell, C. Rodrigo, E. Rodriguez, M. Rodriguez Garcia, S. Saez Jimenez, P. Sanchez Calderon, L. Sanchez Mendez, S. Sanchez Parra, C. Santolaya, M.R. Senan Sanz, A. Seoane Blanco, E. Serralvo, N. Sierra, C. Simon Valero, J. Sorribes Lopez, M. Teixido Fontanillas, M. Terns Riera, G. Tobajas, C. Torres, J. Torres Marques, M. Ubeda Pastor, M. Rosenqvist, A. Wirdby, J. Linden, K. Henriksson, M. Elmersson, A. Egilsson, U. Börjesson, G. Svärd, B. Liu, A. Lindh, L.-B. Olsson, M. Gustavsson, Lars Andersson, Lisbeth Andersson, L. Benson, C. Bothin, A. Hajimirsadeghi, K. Kadir, M. Ericsson, A. Ohlsson, H. Lindvall, P. Svensson, K. Thorne, H. Handel, P. Platonov, B. Eriksson, I. Timberg, K. Romberg, M. Crisby, J.-E. Karlsson, S.A. Jensen, A. Andersson, L. Malmqvist, B. Martinsson, F. Bernsten, J. Engdahl, J. Thulin, A. Hot-Bjelac, P. Stalby, H. Aaröe, E. Ahbeck, H. Ahlmark, F. Al-Khalili, G. Bonkowski, S. Dzeletovic, A.-B. Ekstrand, G.-B. Eriksson, K. Floren, C. Grässjö, S. Hahn, P. Jaensson, B. Jansson, J.-H. Jansson, R.-M. Kangert, A. Koch, D. Kusiak, A. Lettenström, A. Lindberg, C.-J. Lindholm, A. Mannermyr, K. Mansson, M. Millborg, C. Nilsson, A.-M. Ohlin, A. Olofsson, A. Osberg, A. Pedersen, K. Risbecker, K. Rosenberg, J. Samuelsson, M. Shayesteh, K. Skoglund, M. Stjernberg, C. Thorsen, J. Steffel, J.H. Beer, J. Debrunner, D. Amstutz, J. Bruegger, G. Elise, A. Grau, A. Guinand, I. Henriette, E. Saga, S. Winnik, A. Parkhomenko, I. Rudyk, V. Tseluyko, O. Karpenko, S. Zhurba, I. Kraiz, I. Kupnovytska, N. Serediuk, Y. Mostovoy, O. Ushakov, O. Koval, I. Kovalskyi, Y. Svyshchenko, O. Sychov, M. Stanislavchuk, O. Kraydashenko, A. Yagensky, S. Tykhonova, I. Fushtey, R. Belegai, G. Berko, L. Burdeuna, O. Chabanna, I. Daniuk, A. Ivanov, E. Kamenska, P. Kaplan, O. Khyzhnyak, S. Kizim, O. Matova, O. Medentseva, V. Mochonyi, M. Mospan, V. Nemtsova, T. Ovdiienko, O. Palamarchuk, M. Pavelko, R. Petrovskyy, D. Plevak, O. Proshak, S. Pyvovar, L. Rasputina, O. Romanenko, O. Romanova, A. Sapatyi, O. Shumakov, R. Stets, L. Todoriuk, V. Varenov, D. Fitzmaurice, N. Chauhan, D. Goodwin, P. Saunders, R. Evans, J. Leese, P.S. Jhittay, A. Ross, M.S. Kainth, G. Pickavance, J. McDonnell, A. Williams, T. Gooding, H. Wagner, S. Suryani, A. Singal, S. Sircar, R. Bilas, P. Hutchinson, A. Wakeman, M. Stokes, N. Paul, M. Aziz, C. Ramesh, P. Wilson, S. Franklin, S. Fairhead, J. Thompson, V. St Joseph, G. Taylor, D. Tragen, D. Seamark, C. Paul, M. Richardson, A. Jefferies, H. Sharp, H. Jones, C. Giles, M. Page, O. Oginni, J. Aldegather, S. Wetherwell, W. Lumb, P. Evans, F. Scouller, N. Macey, Y. Stipp, R. West, S. Thurston, P. Wadeson, J. Matthews, P. Pandya, A. Gallagher, T. Railton, B. Sinha, D. Russell, J.A. Davies, P. Ainsworth, C.P. Jones, P. Weeks, J. Eden, D. Kernick, W. Murdoch, L. Lumley, R.P. Patel, S.W. Wong, M. Saigol, K. Ladha, K. Douglas, D.F. Cumberlidge, C. Bradshaw, G. Van Zon, K.P. Jones, M.J. Thomas, E. Watson, B. Sarai, N. Ahmad, W. Willcock, J. Cairns, S. Sathananthan, N. de Kare-Silver, A. Gilliland, E. Strieder, A. Howitt, B. Vishwanathan, N. Bird, D. Gray, M. Clark, J. Bisatt, J. Litchfield, E. Fisher, T. Fooks, A.R. Kelsall, E. Alborough, J. Wakeling, M. Parfitt, K. Milne, S. Rogers, R. Priyadharshan, J.L. Oliver, E. Davies, S. Abushal, M. Jacobs, C. Hutton, N.I. Walls, R. Thompson, C. Chigbo, S.M.A. Zaidi, M. Howard, K.C. Butter, S. Barrow, H. Little, I.U. Haq, L. Gibbons, S. Glencross, A.J. McLeod, K. Poland, C. Mulholland, A. Warke, P. Conn, G. Burns, R.N. Smith, S. Lowe, R. Kamath, H.S. Dau, J. Webster, I. Hodgins, S. Vercoe, P.C. Roome, H. Pinnock, J.R.A. Patel, A. Ali, N. Hart, R. Davies, E. Stuart, C.A. Neden, M. Danielsen, R. Heath, P. Sharma, S. Galloway, C. Hawkins, R. Oliver, M. Aylward, S. Mannion, M. Braddick, D. Edwards, A.C. Rothwell, A. Sabir, F. Choudhary, S. Khalaque, A. Wilson, S. Peters, W. Coulson, N. Roberts, A. Heer, S. Coates, B. Ward, D. Jackson, S. Walton, D. Shepherd, M. Sterry, T. Wong, M. Boon, R. Bunney, R. Haria-Shah, R.T. Baron, S. Davies, T. Schatzberger, N. Hargreaves, T. Stephenson, H. Choi, R. Batson, L. Lucraft, T. Myhill, S. Estifano, D. Geatch, J. Wilkinson, R. Veale, K. Forshaw, T. Davies, K. Zaman, P. Vinson, C. Liley, M. Bandrapalli, P. McGinty, R. Wastling, P. McEleny, A. Beattie, P. Cooke, M. Wong, J. Gunasegaram, M. Pugsley, S. Ahmad, C. A'Court, J. Ayers, J. Bennett, S. Cartwright, S. Dobson, C. Dooldeniya, A. Flynn, R. Fox, J. Goram, A. Halpin, A. Hay, P. Jacobs, L. Jeffers, L. Lomax, I. Munro, R. Muvva, M. Nadaph, K. Powell, S. Randfield, D. Redpath, R. Reed, M. Rickenbach, G. Rogers, P.B. Saunders, C. Seamark, J. Shewring, P. Simmons, H. Simper, H. Stoddart, A. Sword, N. Thomas, A. Thomson, H. Gibbs, A. Blenkhorn, B. Singh, W. Van Gaal, W. Abhayaratna, R. Lehman, P. Roberts-Thomson, J. Kilian, D. Coulshed, A. Catanchin, D. Colquhoun, H. Kiat, D. Eccleston, J. French, L. Zimmett, B. Ayres, T. Phan, P. Blombery, D. Crimmins, D. O'Donnell, A. Choi, P. Astridge, M. Arstall, N. Jepson, M. Binnekamp, A. Lee, J. Rogers, G. Starmer, P. Carroll, J. Faunt, A. Aggarwala, L. Barry, C. Batta, R. Beveridge, A. Black, M. Bonner, J. Boys, E. Buckley, M. Campo, L. Carlton, A. Connelly, B. Conway, D. Cresp, H. Dimitri, S. Dixon, M. Dolman, M. Duroux, M. Eskandari, R. Eslick, A. Ferreira-Jardim, T. Fetahovic, D. Fitzpatrick, R. Geraghty, J. Gibbs, T. Grabek, M.H. Modi, K. Hayes, M.P. Hegde, L. Hesketh, B. Hoffmann, B. Jacobson, K. Johnson, C. Juergens, I. Kassam, V. Lawlor, M. Lehman, S. Lehman, D. Leung, S. Mackay, M. MacKenzie, C. McCarthy, C. McIntosh, L. McKeon, H. Morrison, C. Mussap, J.-D. Myers, V. Nagalingam, G. Oldfield, V. O'May, J. Palmer, L. Parsons, K. Patching, T. Patching, V. Paul, M. Plotz, S. Preston, H. Rashad, M. Ratcliffe, S. Raynes, J. Rose, L. Sanders, M. Seremetkoska, H. Setio, S. Shone, P. Shrestha, C. Singh, C. Singleton, N. Stoyanov, S. Sutcliffe, K. Swaraj, J. Tarrant, S. Thompson, I.M. Tsay, M. Vorster, A. Waldman, L. Wallis, E. Wilford, K. Wong, S.J. Connolly, A. Spyropoulos, J. Eikelboom, R. Luton, M. Gupta, A.S. Pandey, S. Cheung, R. Leader, P. Beaudry, F. Ayala-Paredes, J. Berlingieri, J. Heath, G. Poirier, M. Du Preez, R. Nadeau, G. Dresser, R. Dhillon, T. Hruczkowski, B. Schweitzer, B. Coutu, P. Angaran, P. MacDonald, S. Vizel, S. Fikry, R. Parkash, A. Lavoie, J. Cha, B. Ramjattan, J. Bonet, K. Ahmad, L. Aro, T. Aves, K. Beaudry, C. Bergeron, J. Bigcanoe, N. Bignell, L. Breakwell, E. Burke, L. Carroll, B. Clarke, T. Cleveland, S. Daheb, P. Dehghani, I. Denis, Z. Djaidani, P. Dorian, S. Douglass, J. Dunnigan, A. Ewert, D. Farquhar, A. Fearon, L. Ferleyko, D. Fournier, B. Fox, M.-C. Grenier, W. Gulliver, K. Haveman, C. Hines, K. Hines, A.M. Jackson, C. Jean, G. Jethoo, R. Kahlon, S. Kelly, R. Kim, V. Korley, J. Kornder, L. Kwan, J. Largy, C. Lewis, S. Lewis, I. Mangat, R. Moor, J. Navratil, I. Neas, J. Otis, R. Otis, M. Pandey, F. Petrie, A. Pinter, M. Raines, P. Roberts, M. Robinson, G. Sas, S. Schulman, L. Snell, S. Spearson, J. Stevenson, T. Trahey, S. Wong, D. Wright, H. Ragy, A. Abd El-Aziz, S.K. Abou Seif, M.G. El Din, S. El Etriby, A. Elbahry, A. El-Etreby, M. Elkhadem, A. Katta, T. Khairy, A. Mowafy, M. Nawar, A. Ohanissian, A. Reda, M. Reda, H. Salem, N. Sami, S. Samir, M. Setiha, M. Sobhy, A. Soliman, N. Taha, M. Tawfik, E. Zaatout, D. Kettles, J. Bayat, H. Siebert, A. Horak, Y. Kelfkens, R. Garda, T. Pillay, M. Guerra, L. van Zyl, H. Theron, A. Murray, R. Louw, D. Greyling, P. Mntla, V. Ueckermann, R. Loghdey, S. Ismail, F. Ahmed, J. Engelbrecht, A. Ramdass, S. Maharajh, W. Oosthuysen, G. Angel, C. Bester, M. Booysen, C. Boshoff, C. Cannon, S. Cassimjee, C. Chami, G. Conway, A. Davids, L. de Meyer, G. Du Plessis, T. Ellis, L. Henley, M. Karsten, E. Loyd, J. Marks, L. Mavhusa, M. Mostert, A. Page, L. Rikhotso, M. Salie, J. Sasto, F. Shaik, A. Skein, L. Smith, G. Tarr, T. Tau, F. van Zyl, W. Al Mahmeed, G. Yousef, A. Agrawal, M. Nathani, M. Ibrahim, E.M. Esheiba, R. Singh, A. Naguib, M. Abu-Mahfouz, M. Al Omairi, A. Al Naeemi, R. Maruthanayagam, N. Bazargani, A. Wassef, R. Gupta, M. Khan, B. Subbaraman, A. Abdul, A. Al Mulla, S. El Bardisy, P. Haridas, S. Jadhav, K. Magdaluyo, M. Makdad, I. Maqsood, R. Mohamed, N. Sharma, R. Sharma, M. Thanzeel, S.Z. Goldhaber, R. Canosa, P. Rama, E. Blumberg, J. Garcia, P. Mullen, V. Wilson, A. Quick, K. Ferrick, W.M. Kutayli, M. Cox, M. Franco, S. Falkowski, R. Mendelson, M. Williams, S. Miller, S. Beach, A. Alfieri, T. Gutowski, I. Haque, R. Reddy, W. Ahmed, P. Delafontaine, D. Diercks, D. Theodoro, K. Remmel, M. Alberts, R. Ison, H. Noveck, P. Duffy, S. Pitta, D. Nishijima, C. Treasure, N. Asafu-Adjaye, K. Ball, M. Bartlett, M. Bentley, S. Bowers, A. Brown, A. Browne, J. Cameron-Watts, M. Canova, D. Cassidy, K. Cervellione, S. Congal, J. DePauw, A. Dickerson, M. Eley, L. Evans, S. Felpel, K. Ferdinand, D. Fielder, P. Gentry, A. Haideri, F. Hakimi, T. Harbour, E. Hartranft, B. Hawkins, M. Headlee, L. Henson, C. Herrick, T. Hicks, S. Jasinski, A. Jones, L. Jones, P. Jones, S. Karl, M. Keeling, J. Kerr, P. Knowles, J. Langdon, M. Lay, J.A. Lee, T. Lincoln, E. Malone, A. Merliss, D. Merritt, J. Minardo, B. Mooso, C. Orosco, V. Palumbo, M. Parker, T. Parrott, S. Paserchia, G. Pearl, J. Peterson, N. Pickelsimer, T. Purcell, J. Raynor, S. Raziano, C. Richard, T. Richardson, C. Robertson, A. Sage, T. Sanghera, P. Shaw, J. Shoemaker, K. Smith, B. Stephanie, A. Thatcher, H. Theobald, N. Thompson, L. Treasure, T. Tripti, C. Verdi, and V. Worthy
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Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. Methods and results: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012–2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P
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- 2018
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3. Staphylococcus aureus CC30 Lineage and Absence of sed,j,r-Harboring Plasmid Predict Embolism in Infective Endocarditis
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Jean-Philippe Rasigade, Amélie Leclère, François Alla, Adrien Tessier, Michèle Bes, Catherine Lechiche, Véronique Vernet-Garnier, Cédric Laouénan, François Vandenesch, Catherine Leport, The AEPEI Study Group, B. Hoen, X. Duval, F. Alla, A. Bouvet, S. Briancxon, E. Cambau, M. Celard, C. Chirouze, N. Danchin, T. Doco-Lecompte, F. Delahaye, J. Etienne, B. Iung, V. Le Moing, J. F. Obadia, C. Leport, C. Poyart, M. Revest, C. Selton-Suty, C. Strady, P. Tattevin, F. Vandenesch, Y. Bernard, S. Chocron, P. Plesiat, I. Abouliatim, C. De Place, P. Y. Donnio, J. P. Carteaux, C. Lion, N. Aissa, B. Baehrel, R. Jaussaud, P. Nazeyrollas, V. Vernet, P. Nataf, C. Chidiac, H. Aumaître, J. M. Frappier, E. Oziol, A. Sotto, C. Sportouch, M. Bes, P. Abassade, E. Abrial, C. Acar, J. F. Alexandra, N. Amireche, D. Amrein, P. Andre, M. Appriou, M. A. Arnould, P. Assayag, A. Atoui, F. Aziza, N. Baille, N. Bajolle, P. Battistella, S. Baumard, A. Ben Ali, J. Bertrand, S. Bialek, M. Bois Grosse, M. Boixados, F. Borlot, A. Bouchachi, O. Bouche, S. Bouchemal, J. L. Bourdon, L. Brasme, F. Bricaire, E. Brochet, F. J. Bruntz, A. Cady, J. Cailhol, M. P. Caplan, B. Carette, O. Cartry, C. Cazorla, H. Chamagne, H. Champagne, G. Chanques, J. Chastre, B. Chevalier, F. Chometon, C. Christophe, A. Cohen, N. Colin de Verdiere, V. Daneluzzi, L. David, P. De Lentdecker, V. Delcey, P. Deleuze, E. Donal, B. Deroure, V. Descotes-Genon, K. Didier Petit, A. Dinh, V. Doat, F. Duchene, F. Duhoux, M. Dupont, S. Ederhy, O. Epaulard, M. Evest, J. F. Faucher, B. Fantin, E. Fauveau, T. Ferry, M. Fillod, T. Floch, T. Fraisse, J. M. Frapier, L. Freysz, B. Fumery, B. Gachot, S. Gallien, I. Gandjbach, P. Garcon, A. Gaubert, J. L. Genoud, S. Ghiglione, C. Godreuil, A. Grentzinger, L. Groben, D. Gherissi, P. Gue'ret, A. Hagege, N. Hammoudi, F. Heliot, P. Henry, S. Herson, P. Houriez, L. Hustache-Mathieu, O. Huttin, S. Imbert, S. Jaureguiberry, M. Kaaki, A. Konate, J. M. Kuhn, S. Kural Menasche, A. Lafitte, B. Lafon, F. Lanternier, V. Le Chenault, C. Lechiche, S. Lefèvre-Thibaut, A. Lefort, A. Leguerrier, J. Lemoine, L. Lepage, C. Lepouse', J. Leroy, P. Lesprit, L. Letranchant, D. Loisance, G. Loncar, C. Lorentz, P. Mabo, I. Magnin-Poull, T. May, A. Makinson, H. Man, M. Mansouri, O. Marcxon, J. P. Maroni, V. Masse, F. Maurier, M. C. Meyohas, P. L. Michel, C. Michelet, F. Mechaï, O. Merceron, D. Messika-Zeitoun, Z. Metref, V. Meyssonnier, C. Mezher, S. Micheli, M. Monsigny, S. Mouly, B. Mourvillier, O. Nallet, V. Noel, T. Papo, B. Payet, A. Pelletier, P. Perez, J. S. Petit, F. Philippart, E. Piet, C. Plainvert, B. Popovic, J. M. Porte, P. Pradier, R. Ramadan, J. Richemond, M. Rodermann, M. Roncato, I. Roigt, O. Ruyer, M. Saada, J. Schwartz, M. Simon, B. Simorre, S. Skalli, F. Spatz, J. Sudrial, L. Tartiere, A. Terrier De La Chaise, M. C. Thiercelin, D. Thomas, M. Thomas, L. Toko, F. Tournoux, A. Tristan, J. L. Trouillet, L. Tual, A. Vahanian, F. Verdier, V. Vernet Garnier, V. Vidal, P. Weyne, M. Wolff, A. Wynckel, N. Zannad, and P. Y. Zinzius
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S. aureus ,MRSA ,infective endocarditis ,stroke ,CC30 ,enterotoxin ,Microbiology ,QR1-502 - Abstract
Staphylococcus aureus induces severe infective endocarditis (IE) where embolic complications are a major cause of death. Risk factors for embolism have been reported such as a younger age or larger IE vegetations, while methicillin resistance conferred by the mecA gene appeared as a protective factor. It is unclear, however, whether embolism is influenced by other S. aureus characteristics such as clonal complex (CC) or virulence pattern. We examined clinical and microbiological predictors of embolism in a prospective multicentric cohort of 98 French patients with monomicrobial S. aureus IE. The genomic contents of causative isolates were characterized using DNA array. To preserve statistical power, genotypic predictors were restricted to CC, secreted virulence factors and virulence regulators. Multivariate regularized logistic regression identified three independent predictors of embolism. Patients at higher risk were younger than the cohort median age of 62.5 y (adjusted odds ratio [OR] 0.14; 95% confidence interval [CI] 0.05–0.36). S. aureus characteristics predicting embolism were a CC30 genetic background (adjusted OR 9.734; 95% CI 1.53–192.8) and the absence of pIB485-like plasmid-borne enterotoxin-encoding genes sed, sej, and ser (sedjr; adjusted OR 0.07; 95% CI 0.004–0.457). CC30 S. aureus has been repeatedly reported to exhibit enhanced fitness in bloodstream infections, which might impact its ability to cause embolism. sedjr-encoded enterotoxins, whose superantigenic activity is unlikely to protect against embolism, possibly acted as a proxy to others genes of the pIB485-like plasmid found in genetically unrelated isolates from mostly embolism-free patients. mecA did not independently predict embolism but was strongly associated with sedjr. This mecA-sedjr association might have driven previous reports of a negative association of mecA and embolism. Collectively, our results suggest that the influence of S. aureus genotypic features on the risk of embolism may be stronger than previously suspected and independent of clinical risk factors.
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- 2018
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4. Association Between the Tissue and Circulating Advanced Glycation End-Products and the Micro- and Macrovascular Complications in Type 1 Diabetes: The DIABAGE Study
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Diallo, Alpha M., Jaisson, Stéphane, Barriquand, Romain, Lukas, Céline, Barraud, Sara, Decoudier, Bénédicte, Francois, Maud, Ly, Sang, Mahmoudi, Rachid, Arndt, Carl, Nazeyrollas, Pierre, Gillery, Philippe, and Delemer, Brigitte
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- 2022
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5. Cardiac amyloidosis prevalence and 1-year outcome in patients with aortic stenosis undergoing transaortic valve implantation: Findings from the CAMPOS-TAVI study.
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Costa, Jérôme, El-Ali, Ahmed, Morland, David, Dejust, Sebastien, Papathanassiou, Dimitri, Nazeyrollas, Pierre, and Metz, Damien
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[Display omitted] • One in 14 patients (7%) with severe AS undergoing TAVI diagnosed with ATTR-CM. • Targeted screening with Tc99m BS in those at risk (red flags and/or risk scores). • Monoclonal gammopathy excluded. • Emphasis on tailored management for patients with positive BS. • Management includes consideration of TTR stabilizers. • Continued surveillance for ATTR-CM in high-risk patients with negative BS. • More studies needed to define impact of ATTR-CM on long-term prognosis after TAVI. Transthyretin amyloid cardiomyopathy (ATTR-CM) can manifest as rhythm disorders, heart failure, but also valvular degeneration. Despite aortic stenosis (AS) being prevalent among the elderly, data on ATTR-CM prevalence and outcome in patients with AS undergoing transaortic valve implantation (TAVI) remain scarce. To determine ATTR-CM prevalence and evaluate 1-year survival in patients undergoing TAVI. Between December 2020 and September 2021, 100 consecutive patients underwent TAVI and were screened prospectively for ATTR-CM using bone scintigraphy (BS). Monoclonal gammopathy was ruled out in case of cardiac uptake on BS. All patients were followed prospectively for 1 year after TAVI. The proportion of patients aged ≥ 75 years or with a EuroSCORE II > 8% and possible femoral access was 99%. The abnormal cardiac uptake rate on BS was 7% (95% confidence interval: 2–12%); 86% of these patients were male. The RAISE (remodelling, age, injury, system and electrical) score, indicative of ATTR-CM risk, was higher in case of positive BS (P = 0.04). Patients with positive BS were older and exhibited wider QRS complexes on electrocardiography (P = 0.003), a higher frequency of reduced LVEF (57% vs. 17%), impaired basal LV strain (P = 0.02) and a lower voltage/mass ratio (P = 0.01). History of pacemaker implantation before TAVI was higher in the positive BS group (P = 0.0004) and remained the only statistically significant factor after adjustment using the Holm–Bonferroni method. One-year survival of patients with positive BS did not differ from that of patients with isolated AS. Prevalence of ATTR-CM in patients treated with TAVI, underscoring the need for continued surveillance for potential development of ATTR-CM after TAVI. Caution is warranted regarding the 1-year survival because of the lack of study power. Further investigations are needed to define long-term prognosis of AS with ATTR-CM. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Physicians’ exposure to radiation during electrophysiology procedures
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Faroux, Laurent, Daval, Charline, Lesaffre, François, Blanpain, Thierry, Chabert, Jean-Pierre, Martin, Angeline, Guinot, Mathias, Luconi, Nicolas, Espinosa, Madeline, Nazeyrollas, Pierre, Tourneux, Christophe, and Metz, Damien
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- 2019
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7. Performance and economic evaluation of the molecular detection of pathogens for patients with severe infections: the EVAMICA open-label, cluster-randomised, interventional crossover trial
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Cambau, Emmanuelle, Durand-Zaleski, Isabelle, Bretagne, Stéphane, Brun-Buisson, Christian, Cordonnier, Catherine, Duval, Xavier, Herwegh, Stéphanie, Pottecher, Julien, Courcol, René, Bastuji-Garin, Sylvie, Lefort, Agnès, Mantz, Jean, Pease, Sébastien, Lavagna, Leïla, Nicolas-Chanoine, Marie Hélène, Leflon, Véronique, Marcon, Estelle, Ruimy, Raymond, Andremont, Antoine, Lebras, Jacques, Iung, Bernard, Regnier, Bernard, Yeni, Patrick, Montravers, Philippe, Mourvillier, Bruno, Ilic-Habensus, Emila, Talbi, Nadia El Alami, Lasocki, Sigismond, Bouscary, Didier, Mira, Jean-Paul, Grimaldi, David, Marin, Nathalie, Doloy, Alexandra, Poyart, Claire, Scherrer, Emmanuel, Chambon-Pautas, Cecile, Cook, Fabrice, Mekontso-Dessap, Armand, Schortgen, Frédérique, Chedevergne, Karine, Vernant, Jean-Paul, Gauvin-Bodin, Liliane, Trouillet, Jean-Louis, Chastre, Jean, Bricaire, François, Brossier, Florence, Jarlier, Vincent, Dheder, Nathalie, Nieszkowska, Ania, Datry, Annick, Fekkar, Arnaud, Buffet, Pierre, Mazier, Rommy, Brun, Sophie, Meyssonnier, Vanina, Isnard, Françoise, Baudel, Jean-Luc, Meynard, Jean-Luc, Petit, Jean-Claude, Lalande, Valérie, Roux, Patricia, Raffoux, Emmanuel, Ribaud, Patricia, Das, Vincent, Schlemmer, Benoit, Azoulay, Elie, Chimot, Loic, Molina, Jean-Michel, Ponscarme, Diane, Pavie, Juliette, Simon, François, Casin, Isabelle, Menotti, Jean, Gruson, Didier, Bessède, Emilie, Guilhon, Emmanuelle, Accoceberry, Isabelle, Millet, Pascal, Bébéar, Cécile, Berthoux, Christian, Tonnelier, Jean-Marie, Garre, Michel, Hery-Arnaud, Geneviève, Payan, Christopher, Nevez, Gilles, Timsit, Jean-Francois, Cahn, Jean-Yves, Brion, Jean-Paul, Le beau, Bernard, Courby, Stephane, Pelloux, Hervé, Maurin, Max, Epaulard, Olivier, Hamidfar, Rebecca, Berthon, Céline, Coiteux, Valérie, Terriou, Louis, Nseir, Saadalla, Auffray, Jean-Luc, Jouet, Jean-Pierre, Durocher, Alain, Faure, Karine, Clavel, Marc, Camus, Daniel, Dugard, Anthony, Tisseuil, Chantal, Duchiron, Cécile, Ajzenberg, Daniel, Bordessoule, Dominique, Garnier, Fabien, François, Bruno, Ploy, Marie-Cécile, Darde, Marie-Laure, Chaury, Marie-Pierre, Giraud, Stephane, Jaccard, Arnaud, Moreau, Stéphane, Réménieras, Liliane, Touati, Mohamed, Turlure, Pascal, Amiel, Jean-Bernard, Pichon, Nicolas, Postil, Déborah, Vignon, Philippe, Espinouse, Daniel, Jacques, Didier, De Monbrison, Frédérique, Grozel, Jean-Michel, Chomarat, Monique, Gueugniaud, Pierre-Yves, Sanogo, Rokiatou, Drancourt, Michel, Fournier, Pierre Edouard, Roux, Véronique, Delmer, Alain, Himberlin, Chantal, Kolb, Brigitte, Lé, Quoc Hung, Appriou, Morgane, Cousson, Joël, Nazeyrollas, Pierre, Strady, Christophe, Dechamps, Christophe, Vernet, Véronique, Delmer, Alain, Toubas, Dominique, Guyotat, Denis, Auboyer, Christian, Zeni, Fabrice, Alamartine, Eric, Cathebras, Pascal, Lucht, Frédéric, Viallon, Alain, Melis, Adrien, Ros, Alain, Carricajo, Anne, Devanlay, Camille, Labruyere, Carine, Vautrin, Catherine, Cazorla, Céline, Tavernier, Emmanuelle, Grattard, Florence, Aubert, Gérald, Morel, Jerome, Cornillon, Jérome, Abba, Karima, Flori, Pierre, Sung, Roger Tran Manh, Pozzetto, Bruno, Schneider, Francis, Hansmann, Yves, Herbrecht, Raoul, Jaulhac, Benoit, Piémont, Yves, Lestcher, Valérie, Colombat, Philippe, Senecal, Delphine, Garot, Denis, Perrottin, Dominique, Besnier, Jean-Marc, Goudeau, Alain, Lanotte, Philippe, Chandenier, Jacques, Baloul, Samia, Corbel, Céline, Dabbech, Moufida, Gaba, Mabel, Jozefowicz, Elsa, Lafaye, Magali, Maugard, Fabien, Rabeuf, Remi, Rabetrano, Hasina, Veerabudun, Kalaivani, Viallette, Cédric, Stahl, Jean-Paul, Delhaes, Laurence, and The EVAMICA study team
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- 2017
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8. Voltage/mass ratio (VMR) prognosis value in heart failure (HF) patients with transthyretin cardiac amyloidosis (ATTR-CA)
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J Costa, M Pierre, and P Nazeyrollas
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Cardiology and Cardiovascular Medicine - Abstract
Funding Acknowledgements Type of funding sources: None. Introduction Transthyretin cardiac amyloidosis (ATTR-CA) is an emerging cause of heart failure (HF) and is associated with cardiac mass hypertrophy and voltage impairment, but little is known on how theses markers interplay with survival. Objective To evaluate if cardiac voltage/mass ratio (VMR) is associated with prognosis in HF patients involving ATTR-CA. Methods Patients with confirmed mutated (m) or wild-type (wt) ATTR-CA addressed in a single cardiology center underwent retrospective ECG and echocardiographic study to define voltage with Sokolow indice (SV1+RV5, in mV) and left ventricular mass (LVM, g/m²) according to ASE definition. Two groups of patients were defined according to the median cardiac voltage/mass ratio (VMR in µV/g/m²) : Low (VMR < 6.1) or normal (VMR ≥ 6.1). Tc99m-HDP myocardial uptake (MU) on bone scintigraphy (BS) was described according to Perugini (P) classification : PI (MU < chest bones), PII (MU = chest bones) and PIII (MU > bones). Main end-point was overall mortality. Results Among the 74 patients included, mean age was 82±7 years, 80% were males (Graph 1) and 25 (34%) were classified as ATTRwt-CA, 3 (4%) as ATTRm-CA, and 46 (62%) had ongoing genetic exploration. Mean follow-up was 543±332 days. Overall mortality was 21%. On BS, 6 patients (8%) were ranked as PI, 30 (42%) PII and 36 (50%) PIII, with no difference on mortality rates. After ANOVA, mean VMRi significantly decreased with intensity of Tc99m-HDP myocardial uptake on BS (p=0.033, Graph 2A). After log-rank test, survival was impaired in the low VMR group (p=0.034, Graph 2B). After Cox regression, low voltage/masse ratio remained associated with increased risk of mortality (HR 4.6, 95% CI [1.1–18.6], p=0.03), after adjusting on age, sex, left ventricle ejection fraction and log(NT-proBNP). Conclusion VMR is a simple index to collect and significantly associated with impaired survival in HF patients with ATTR-CA. Further studies are needed to confirm these results.
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- 2023
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9. Factors influencing the use of the “not for generic substitution” mention for prescriptions in primary care: a survey with general practitioners
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Beauvais, Virgil, Marque, Annabelle, Ferté, Guillaume, Chrusciel, Jan, Souille, Julie, Nazeyrollas, Pierre, and Sanchez, Stéphane
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- 2018
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10. Circadian disturbance and idiopathic central serous chorioretinopathy
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Setrouk, Elodie, Hubault, Beatrice, Vankemmel, Frédérique, Zambrowski, Olivia, Nazeyrollas, Pierre, Delemer, Brigitte, Durlach, Vincent, Ducasse, Alain, and Arndt, Carl
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- 2016
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11. Echocardiographic assessment of right ventricular function and right ventriculoarterial coupling in tricuspid regurgitation
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L. Trousselle, F. Eggenspieler, L. Faroux, P. Nazeyrollas, O. Huttin, N. Pace, L. Filippetti, A. Fraix, B. Carquin, C. Selton-Suty, and D. Metz
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Cardiology and Cardiovascular Medicine - Published
- 2023
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12. The impact of transoesophageal echocardiography in elderly patients with infective endocarditis.
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N'cho-Mottoh, Marie-Paule B., Erpelding, Marie-Line, Roubaud, Claire, Delahaye, François, Fraisse, Thibaut, Dijos, Marina, Ennezat, Pierre-Vladimir, Fluttaz, Arnaud, Richard, Benjamin, Beaufort, Corinne, Nazeyrollas, Pierre, Brasselet, Camille, Pineau, Olivier, Tattevin, Pierre, Curlier, Elodie, Iung, Bernard, Forestier, Emmanuel, and Selton-Suty, Christine
- Abstract
[Display omitted] • We compared patients aged > 75 years treated for IE, who did/did not undergo TEE. • Patients without TEE were older, with more comorbidities. • Patients without TEE had poorer functional, nutritional and cognitive statuses. • Patients without TEE underwent surgery for a recognized indication less often. • Patients without TEE had a poorer prognosis. Infective endocarditis (IE) increasingly involves older patients. Geriatric status may influence diagnostic and therapeutic decisions. To describe transoesophageal echocardiography (TEE) use in elderly IE patients, and its impact on therapeutic management and mortality. A multicentre prospective observational study (ELDERL-IE) included 120 patients aged ≥75 years with definite or possible IE: mean age 83.1± 5.0; range 75–101 years; 56 females (46.7%). Patients had an initial comprehensive geriatric assessment, and 3-month and 1-year follow-up. Comparisons were made between patients who did or did not undergo TEE. Transthoracic echocardiography revealed IE-related abnormalities in 85 patients (70.8%). Only 77 patients (64.2%) had TEE. Patients without TEE were older (85.4 ± 6.0 vs. 81.9 ± 3.9 years; P = 0.0011), had more comorbidities (Cumulative Illness Rating Scale-Geriatric score 17.9 ± 7.8 vs. 12.8 ± 6.7; P = 0.0005), more often had no history of valvular disease (60.5% vs. 37.7%; P = 0.0363), had a trend toward a higher Staphylococcus aureus infection rate (34.9% vs. 22.1%; P = 0.13) and less often an abscess (4.7% vs. 22.1%; P = 0.0122). Regarding the comprehensive geriatric assessment, patients without TEE had poorer functional, nutritional and cognitive statuses. Surgery was performed in 19 (15.8%) patients, all with TEE, was theoretically indicated but not performed in 15 (19.5%) patients with and 6 (14.0%) without TEE, and was not indicated in 43 (55.8%) patients with and 37 (86.0%) without TEE (P = 0.0006). Mortality was significantly higher in patients without TEE. Despite similar IE features, surgical indication was less frequently recognized in patients without TEE, who less often had surgery and had a poorer prognosis. Cardiac lesions might have been underdiagnosed in the absence of TEE, hampering optimal therapeutic management. Advice of geriatricians should help cardiologists to better use TEE in elderly patients with suspected IE. [ABSTRACT FROM AUTHOR]
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- 2023
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13. Complications des procédures invasives coronaires chez les nonagénaires : une étude cas-témoins
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P. Nazeyrollas, M. Dacunka, S. Sanchez, B. Mailler, A. Al Amoura, L. Chapoutot, F. Raoul, B. Girodet, and A. Marchais
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Gynecology ,03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,medicine ,030204 cardiovascular system & hematology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Resume Introduction La pathologie coronarienne constitue la premiere cause de morbi-mortalite chez les patients nonagenaires, dont le nombre a double en vingt ans. En l’absence de recommandations, la place de la strategie invasive coronaire dans cette population reste un challenge therapeutique, et son interet ainsi que ses risques mal etablis. Le but de notre etude etait d’evaluer la securite de la pratique invasive coronaire dans la population nonagenaire toutes indications confondues. Population et methodes Il s’agissait d’une etude cas-temoin monocentrique menee du 1er janvier 2010 au 30 mai 2019. Les patients inclus etaient l’ensemble des nonagenaires ayant beneficie d’une coronarographie au centre hospitalier de Troyes au cours de cette periode. Pour chaque patient inclus, deux temoins apparies sur le sexe, la date de procedure et l’acte ont ete tires au sort. Le critere de jugement principal etait la survenue de complications per- ou post-procedures immediates durant le sejour au cours duquel etait realisee la procedure. Les principaux criteres de jugement secondaire etaient la duree moyenne de sejour, la survenue d’evenements intercurrents durant le sejour (infections nosocomiales, syndrome confusionnel) et la survenue d’une perte d’autonomie. Resultats Au total, 59 nonagenaires et 118 temoins ont ete inclus dans notre etude. Nous avons recense 30,5 % de complications majeures chez les nonagenaires versus 10,2 % chez les temoins (p = 0,001 ; OR = 0,26 [0,1–0,6]), avec une difference significative portant sur la survenue d’un choc cardiogenique (p = 0,04), d’une insuffisance cardiaque (p = 0,02) et de troubles rythmiques ventriculaires (p = 0,04). L’insuffisance renale aigue post-procedure etait plus importante chez les nonagenaires (p = 0,02 ; OR = 0,20 [0,05–1,57]). La duree moyenne de sejour etait en moyenne deux fois plus longue chez les nonagenaires. Conclusion Les patients nonagenaires sont sujets a plus de complications lors de la realisation d’une procedure invasive coronaire par rapport a des patients de moins 75 ans.
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- 2020
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14. Relationship between severity of HDP-99mTc myocardial uptake on bone scintigraphy (BS) and severity of cardiac involvement in transthyretine cardiac amyloïdosis (TTR-CA)
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J. Costa, M. Pierre, P. Nazeyrollas, and D. Metz
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Cardiology and Cardiovascular Medicine - Published
- 2023
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15. Screening for frailty in elderly subjects living at home: Validation of the modified Short Emergency Geriatric Assessment (SEGAm) instrument
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Oubaya, N., Mahmoudi, R., Jolly, D., Zulfiqar, A. -A., Quignard, E., Cunin, C., Nazeyrollas, P., Novella, J. -L., and Dramé, Moustapha
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- 2014
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16. Cardiac rehabilitation in COVID-19 pandemic period
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J C Costa, I Mouici, L Bichon-Treulet, P Nazeyrollas, and D Metz
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Cardiology and Cardiovascular Medicine - Abstract
Background The current COVID-19 pandemic constitutes a challenge in cardiovascular disease (CVD) management. Little is known on how the virus impacts cardiac rehabilitation (CR) programs (CRP) safety and efficacy. Aim To evaluate the efficacy of basic sanitary procedures to limit the risk of virus spreading in patients undergoing cardiac rehabilitation in ambulatory setting. Methods From august to October 2020, all patients admitted in a single ambulatory CR program were screened for COVID-19 infection before and after CR. Negative naso-pharyngeal swab through RT-PCR was mandatory within seven days before starting the program, and advised after leaving the program. Serologic tests were also advised before and after the CRP. Number of patients were reduced from 9 to 4 in each group, 2 meters distancing respected, and all patients and staff had to wear surgical mask during sessions. Regular hand washing and hydro-alcoholic solutions use were mandatory for both patients and health professionnals. Material disinfection was systematic before and after each session. Results Among the 81 patients included, 63 (76%) were male, mean age was 57±11 years (see table). Sanitary protection measures were well applied and tolerated, especially use of surgical mask during exercice sessions. After RT-PCR on nasal swab, none (0%) were positive before entering CR and only 2 (2.7%) were tested positive after CR. These two patients were asymptomatic. The other patients in the same group as those having positive nasal test after CR were tested negative and were asymptomatic. According to serological analysis, the same 3 patients (3.8%) had anti-bodies against SARS-COV-2 before and after participating CR (see graph). These 3 patients were negative on nasal swab before and after CR. No seroconversion was observed. Mean delay between first and second RT-PCR on nasal swab and serological analysis were 30±15 and 32±15 days, respectively. In total (before and after CR), 5 patients (6.0%) were tested positive with SARS-COV-2. Those 5 patients were younger (mean age 51 years old versus 58, p=0.2), with better functional capacity before and after CR: respectively 7.1 METs (versus 5.2 METs, p=0.014) and 8.3 METs (versus 6.3 METs, p=0.03). In COVID+ patients, improvement of functional capacity was similar to COVID− patients: respectively 0.8 METs (p=0.9) and 15 Watts (p=0.9). Conclusion During COVID-19 pandemic, cardiac rehabilitation is not associated with risk of infection with SARS-CoV-2, provided that basic sanitary measures are stricly applied. It is also associated with functionnal capacity improvement, especially in patients who previously had COVID-19. Funding Acknowledgement Type of funding sources: None. Patients baseline characteristics in CRPatients COVID-19 status in CR
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- 2021
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17. Comprehensive geriatric assessment in older patients suffering from infective endocarditis. A prospective multicentric cohort study
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E. Forestier, C. Roubaud-Baudron, T. Fraisse, C. Patry, G. Gavazzi, B. Hoen, P. Carauz-Paz, B. Moheb-Khosravi, F. Delahaye, G. Sost, M. Paccalin, P. Nazeyrollas, C. Strady, F. Alla, C. Selton-Suty, S. Schambach, d’O. Vallette, B.M. Khosravi, C. Roubaud, A. Lafargue, F. Guerville, D. Kobeh, E. Averty, L. Thiennaud, E. Soulas, T. Basileu, M. Chuzeville, M.-C. Laurain, J.L. Novella, L.A. Bertholon, Y. Jaidi, R. Guiard, J. Naturel, V. Vitrat, X. Duval, G. Wirth, P. Pavese, I. Pierre, É. Fernandes, E. Curlier, A. Boibieux, F. Goehringer, G. Béraud, Y. Nguyen, P. Tattevin, M. Revest, C. Piau, P.C. Paz, A.-C. Vançon, N. Naem, B. Richard, B. Iung, M. Dijos, A. Fluttaz, P.-V. Ennezat, C. Beaufort, F. Torossian, C. Brasselet, E. Donal, O. Pineau, N. Agrinier, M.-L. Erpelding, W.N. Sime, G. Clavère, M. Lebouc, E. Ilic-Habensus, J. Durrieu, T. Habet, C. Dupré, A.-M. Chaissac, S. Touati, A. Delahaye, E. Marquis, M. Warchol, E. Thébault, C. Jouan, C. Campagnac, and I. Petitgenêt
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Male ,0301 basic medicine ,Microbiology (medical) ,Pediatrics ,medicine.medical_specialty ,030106 microbiology ,Nutritional Status ,Comorbidity ,03 medical and health sciences ,0302 clinical medicine ,Older patients ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Geriatric Assessment ,Aged ,Aged, 80 and over ,Old patients ,Endocarditis ,business.industry ,Mean age ,Geriatric assessment ,General Medicine ,medicine.disease ,Survival Analysis ,Hospitalization ,Infectious Diseases ,Infective endocarditis ,Female ,Functional status ,France ,business ,Cohort study - Abstract
The aim was to describe the impact of infective endocarditis (IE) on functional, cognitive and nutritional statuses, and to estimate the influence of these parameters on surgical management and mortality.This was a prospective study over 13 months in 14 French hospitals, including patients ≥75 years of age with definite or possible IE. A comprehensive geriatric assessment (CGA) was performed during the first week of hospitalization, including a retrospective estimation of functional status 2 months before hospitalization, and 3 months after.A total of 120 patients were included (mean age 83.1 ± 5.0 (75-101) years). IE was associated with a dramatic impairment of functional status between 2 months prior hospitalization and the first geriatric evaluation (90.8% able to walk vs. 35.5% (p 0.0001), ADL (Activities in Daily Living) 5.0 ± 1.7 vs. 3.1 ± 2.1 (p 0.0001)). The 19 operated patients (15.8%) had less comorbidities (cumulative illness rating scale geriatric 10.8 ± 8.2 vs. 15.3 ± 7.1 (p 0.0176)), better functional (ADL 5.9 ± 0.4 vs. 4.9 ± 1.8 (p 0.0171) and nutritional (mini nutritional assessment 20.4 ± 5.0 vs. 17.3 ± 6.2 (p 0.0501)) statuses than non-operated patients. Among all infectious, cardiac and geriatric parameters, body mass index (HR 0.9, range 0.8-1, p 0.05) and ADL at the time of the first evaluation (HR 0.7, range 0.6-0.9, p 0.002) were the sole independent predictors of the 3-month (32.5%) and 1-year mortality (42.5%). Three months later, the 57 assessed patients only partially recovered their ADL (3.7 ± 1.9 vs. 5.3 ± 1.4 2 months prior hospitalization and 4.6 ± 1.9 at the first CGA; p 0.0001).Functional and nutritional abilities are crucial components that can be accurately explored through a CGA when managing IE in oldest patients.
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- 2019
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18. Is obesity a marker of robustness in vulnerable hospitalized aged populations? Prospective, multicenter cohort study of 1 306 acutely ill patients
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Lang, Pierre Olivier, Mahmoudi, R., Novella, J. -L., Tardieu, E., Bertholon, L. -A., Nazeyrollas, P., Blanchard, F., Jolly, D., and Drame, M.
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- 2014
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19. Cardiac AMyloïdosis Prevalence and Outcome in aortic Stenosis patients undergoing Transcatheter Aortic Valve Implantation: First insight of the CAMPOS-TAVI study
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J. Costa, A. El Ali, N. Semaan, C. Barbe, P. Nazeyrollas, D. Morland, S. Dejust, D. Papathanassiou, and D. Metz
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Cardiology and Cardiovascular Medicine - Published
- 2022
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20. Prevalence of diabetic and impact on cardiovascular events and mortality in patients with chronic coronary syndromes, across multiple geographical regions and ethnicities
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H Appeltants, C Boesch, I Cromarty, D Carretta, S Romanov, U Windstetter, F Mibach, Jens Refsgaard, S Lebedev, F Proietti, M Y Tamimi, M C Gamboa, M Novikova, E Prada, K H Sim, E Messas, E Zherlitsyna, A Kalampalikis, N Nevolina, N Trocan, J Cohen, G Szto, R Gilabert Gómez, M Omelchenko, A Pinzani, D Goodwin, J Umaran Sánchez, Kim Fox, S H Dong, K Kronberg, E Castillo Lueña, T Ignatieva, S Joubert, C Macchi, S Lee, S Eidelman, F Alizon, S Chandra, M Akbar, D M Colquhoun, G Yanes Bowden, J de Juan Baguda, M Sebastian, C Wernham, K Miedema, R La Greca, C Morton, B S Jheeta, A C Tran, T Q Do, O Rodrigues, J Yan, S H Kim, R Jurgaitienė, Jean-Claude Tardif, R Baleón, D Hay, V Hennebelle, F Fazekas, R Davies, P Gratia, L Sorodoc, S Y Wu, C Martínez Sánchez, L Lopes Antunes, T H T Pham, I Suliman, M J Gómez Martinez, A Pernat, S H Hur, M Alanazy, L Zhabina, M Stanley, J Rogers, Y J Kim, S Geffroy, L K Andersen, S Coman, V Pedrosa del Moral, Y Garaud, J Krupicka, O Dzhkha, C Paul, M Jeżewska, B Mahler Mioto, V Abduvalieva, P Morra, L Kucheryava, C La Rosa, B Chan, M Wrębiak-Trznadel, A Kozlowski, M Sharif, L López Barreiro, V Kolesnikov, M Lawrence, A Tucker, C Okawabata, B La Hay, E Sadauskienė, B K Nguyen, L Bui, A Said, M E Ruíz Esparza, R K Saran, M S C Ho, E Homs Espinach, J R Romo Santana, J Forte De Carvalho, I Pattison, H H Phan, L Baleeva, L Kisiel, A López Granados, C Raters, F Paganelli, R Haberl, A P T Wong, D Xu, R Jagathesan, L Grekhova, H Stursova, Q B Truong, P Raymond, Y Sosnova, N H Khong, J Zarauza Navarro, C Florescu, L Gorshkova, N Saaidin, E Gordillo Higuero, L Davin, I Budanova, C Lavicka, L Gruznykh, P Bogdański, A Dufka, I Arroja, H A R Tahir, G Wilson, G Kolios, S J Yoon, Simon Cattan, K Berdnik, A Serrano, B Sievers, A Rodríguez Almodóvar, L A Holden, F O'Reilly, D Verleyen, H Hafez, K Nehrig, S M Kang, S Berrisch-Rahmel, E Meyer-Michael, P Samama, L Soares, A K Nguyen, F Tuktarova, C Weytjens, E Sandoval Rodriguez, J Cheng, F M Villasenor, João Morais, B Sullivan, R Zimoląg, Albert V. Smith, S F Ding, J C Louchart, G Guardigli, R Furtak, P Azzolini, S Chushak, J L Delgado Prieto, S Kornienko, K K Sia, J H Shin, F Baylac Domengetroy, P Błaszczak, M Saade, N Černič-Šuligoj, K Coetzee, A Kadleckova, V Scollo, O Larina, R Pal, M M Singh, N Nosova, R Burns, B S Yoo, O Gukov, F Massari, V Antia, A Brattström, G Holt, M Scherbak, V Firastrau, Y J Li, E Mikhailova, L Machado Cesar, C García García, J Pjontek, C Everton Biglow, G Pes, C Brown, A Bumbu, S Felis, R Bosch, M Lazaro, Luigi Tavazzi, R Engel, I Romeo Castillejo, Y S Byun, F Matias, I Grushetskaya, C Mestre-Fernandes, T Kheliya, S Schlesingerova, G Theodorakis, I Tsamopoulos, R Pedretti, A Puente Barragán, M P Vo, B Lammens, T Carruthers, J S Bhatt, A Khodanov, N Pasechnaya, I Petrova, G Boutros, I A Khan, E Le Moal, D Garofalo, H R Malaterre, A Bahal, J F Martínez González, H N Dinh, N V Pham, C Barjhoux, I Gilmour, C Soriano Navarro, O D Chioncel, K Tóth, N Borodina, P Khanoyan, B Sevilla Toral, H H Kim, C M A Bui, C Dernedde, N Eliseeva, M Galinier, E Kosachek, M M Doohan, L Potapska, M Tennekoon, R Nourallah, L Perez De Isla, K H Chee, E Panova, D M Walker, G Glanowska, G Hua, A Silvestre, W Wang, Matthew A. 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Velez Edwards, A Buakhamsri, N Bazargani, U Spengler, M Toringhibel, M A Matos, I Skoczylas, V Arrarte Esteban, J Fuertes Beneitez, V Gil, L U P Tran, A Mehta, A Álvarez Sangabriel, P Di Pasquale, K Egstrup, P Choudhury, S Whetstone, T S Chee, M Elkohen, P Martina, J Martínez Rivero, C Arden, J Walczewska, I Benett, R Silvestri, V García Saavedra, J Słaboszewska, A Thomson, S Revienė, A Szpak, V Challenor, F Saporito, P Ruiz Pérez, Vives, H M Li, I Sadykova, D Lawton, T Kuzmina, R Elias, D Troup, P Dehayes, J Vavougios, V Pernice, P Tanielian, R Cabrera Solé, T Pitsch, R Nethononda, P Poinson, A Tavares E Taveira, J Yi-MingCha, J Y Hwang, T Haghfelt, C García Pindado, N Bilous, A Kotsalos, M Bariaud, A Drzewiecka, L Polkina, V Arfaras, P Vymetal, J Rawal, A Aumjaud, H P Wang, L Wu Amen, J Fernandes, F Howie, A Ouguoujil, M H Ngo, J A Bertarini, A Malysheva, G De Geeter, N Aimouch, R Parkin, H Taylor, M Kittipovanonth, A Gupte, S Ramanaidu, L Basto, A Zherebtsova, T Arsentieva, V Männl, Y L Cham, J J Gómez Doblas, D Ennouchi, Iveta Mintale, A Vance, R Jirmar, L Boikova, D T Le, P Srivastava, L Tonet, M Liautard, C Proto, Q H Do, Mª A Pérez Martínez, R Stankevičius, L Semedo, M Anghel, I Nikolaeva, J Janes, H Al-Backer, M C Escourrou Berdou, O Leshchuk, D Reshotko, V P Dang, I Édes, L Schlueter, B Sikorska-Buczkowska, K Hatalova, I Marozsán, S Gessner, J Gmehling, M Kuzmicheva, Z Huang, L Kosareva, D K Kumbla, A Baika, F El-Shaer, T Voronova, J M Chopo Alcubilla, A Veternik, S Mohr, D Garcia, J Y Rhew, C K Yeo, C De Niel, H K N Nguyen, E Orts Soler, J Dubrava, S Natarajan, M S H Khan, U Kossowska, J P Detienne, T T H Nguyen, I Centa, M G Millauer, Jose Lopez-Sendon, J T Counsell, E Galehr, T Schröder, L Frost, P P Singh, C Moya López, R Beyer, L Carpentier, J Carrillo Calvillo, Z M Du, R Steeds, E Horstkotte, P Kindler, P Johnson, M Sander, I Rodríguez Tejero, F Azar Manzur, S Brown, M Odín de los Ríos Ibarra, C K Choor, M A Sadiq, D B Gysan, V B Doan, A Gueusquin, M Andrews, L L Feng, B Martina-Hooi, S R Shetty, Y Dascotte, E T Ch'ng, P Dematteo, A Woodall, S Gabriilidis, Jean Ferrières, S K Oh, J Lindford, S Blignaut, L Macedo, R Carrillo Cardoso, Y C Lai, C Lang, S R Jayasinghe, B Bastian, V Sanfins, J de Jeús Zuñiga, F X Meriaux, G Sepp, S Molotyagina, S García Ortego, T Perger, Y Lukina, J H Wirtz, A Regulska, P Durand, P Loheac, J Sinnadurai, S Avlonitis, J García-Moll Marimón, J Bradley, K Pareathumby, L Latyntseva, D Stergiou, K Ling, S K Hong, N S Chonkar, C Goldie, C C Koo, A Salustri, Y Peneva, I Rodríguez Briones, P Ferreira, L Franskyavichene, G Bragança, C Rodrigues, S H Lee, L Dang, B J Lubelsky, L Weinrich, E Hoffer, J Tricoire, M Marachli, O Smirnova, C Falces Salvador, A Mobeirek, M Fagan, A Serazhim, M M W Yeung, F Petitjean, I Cullen, J Benacka, Yañez Wonenburger, D Gentille Lorente, J Ferreira Dos Santos, F Bosa Ojeda, N Marchionni, L Brottier, P Keelan, D Kerö, L Moretti, R Seabra Gomes, I Jasinkevica, P Purnode, D Relange, H N Luqman, A Petit, I Hamilton-Craig, E Kochurov, P Berry, P Aguar Carrascosa, M Noble, S Yvorra, N Razzaq, J M Walch, L Lenartowska, R Sethi, W Kim, C Killeen, S Kurochkina, N Capuano, P Sampson, K H Mak, T Bouchaya, J Hellermann, M Geneves, F Ramos Ariznabarreta, J L Mougeolle, J Ferreira, T Roy, J de Andrés Novales, J F Monteiro Ferreira, M S Mayer, N Lopez Cabanillas, P Touzet, K H Ng, F Pelier, T K Huynh, J Schindler, T Krechunova, A Gaglione, Z Fras, P Haralambus, R Pradhan, L P Low, G Odent, M Sidor, R Sopia, D Janody, T K Ong, K Adamaszek, G Vives Boniato, T Maxwell, H Charles, D Gough, O Dibon, A A Abdul Rahim, H B Liew, S Tikhonova, I Bläse, J Chambel De Aguiar, E Santas Olmeda, M Rosseel, R Angela, D Savard, C Cernetti, O Huttin, J Calder, O Kilaberiya, A Elkrail, I I Tulevski, A Ilyukhina, E Chalkiadakis, R Antonicelli, H C Gwon, G Bautista López, G Brown, J Kojelienė, R Zeitouni, J Mimoso, N Better, N H Vu, H Abdel Wahab, B Poprawa, F Weber, A Ghicu, K Rybak, G Fouquet, C Pindado Rodríguez, A Salakhova, L Isaeva, M H Fallacher, J Placke, G McCansh, V D Tran, O Gusev, D Enayat, P Khera, E Brice, G Levesque, A Alvarez Auñon, M A Arnau, M A López Aranda, E Andreicheva, I Kruck, R Grigoriu, I Sainz Hidalgo, M Węglarz, A Ajani, I Khudina, T Makhieva, V D Dang, R Testa, E Cisowska-Drozd, F Giacomazzi, R Cierpka, Nicola Greenlaw, P Wong, L Simões, L Tsaryabina, O Gureeva, R Raffelsberger, H Luquez, A Rainbird, D Evéquoz, M A Balice-Pasquinelli, R Massay, K L Joseph, I H Chae, R Herrmann, I Salecker, A Montero Gaspar, P F Fonseca, A Martin, W Czarnecki, R Motomancea, E Dechoux, M Shamsuzzaman, M Leandri, D Marzal Martín, C Navas Navas, C Beaurain, T Gkinis, K Shetty, P A Jeannerat, D S Wong, A Gonzaga, W Kulig, J F Millet, E Jankauskienė, E Anastasiou, A I Ruhani, N Aksyutina, O Kolesova, K Yared, M Panajatovic, Y L Zhou, S Thurston, T Alekseeva, S Preston, N Mai, M Kuzyakina, D Rechtman, T Boonyasirinant, J Nobre Dos santos, A Ahuad Guerrero, M Al-Shamiri, M Feldner-Busztin, S Godart, S Liandrat, A Narayan, L Burlakova, M J García Martínez, C Militaru, J Chávez Paez, H B Matheson, D Meddah, P Brindle, N Petrova, A Nicolino, D Spensieri, A Giuca, E Molina Laborda, J Moreno Arribas, V Martinho, T Mularek-Kubzdela, S K Chua, G A Dan, N T H Tu, V T Nguyen, M Alcocer Gamba, J Costa, H Milligan, R Badr-Eslam, E Variava, A Merkhi, C Mays, R De Castro Aritmendiz, A K Mohamed Yusof, A Hamer, R McNeilly, S Dedkova, D Rousson, K Chamou, A Mahr, D C Dan, R Till, T L Yang, M Vida Gutiérrez, D Piyayotai, É Bajcsi, D Zaronskienė, I Alexopoulos, Y Huo, H S Zeng, P Rowe, S Fleming, D B Vu, Á Dongó, C Hand, J C S Leong, M Claeys, S Hood, J Bozkova, G Vieyra, G Unger, A Liqui-Lung, D Cremer Luengo, M Castillo Orive, S Muth, M Joseph, P L Torres Díaz, C Zakopoulos, D Cross, F Trujillo Berraquero, F Sattar, H A Boyrazian, T B Le, M Mantcheva, M Constantinescu, P Gosse, U Keil, G F Vaz, M Bdeir, T S Pham, M J García González, J K Ryu, D W Jeon, Zs Malkócs, J Á Perea Egido, R Izquierdo González, V Probst, E Wellenkamp, C Boureux, M Czarnecka, C Vaughan, H Falconer, H Brunner, G Peña Pérez, E Nelböck-Huber, E Blanc, F Thomas-Richard, A L R Ng, M Provvidenza, R Gascueña Rubia, J Freitas, A Dabboura, B Mörz-Proszowski, A Utech, C Alves, C M David, J A Lastra Galán, L Oliveira, T A Nguyen, I Ghaly, A Hofmeister, I Gorodilova, P Szałkowski, M S Hiremath, G Golovina, C Daly, M Tardy, S Kostomarova, J-P Salembier, P Zagožen, D Wang, M Vogel, J Borbola, I Chlewicka, K-H Schmitz, C Pappas, J Victory, M Garandeau, P Wiggers, C Piñero Ramírez, L Tkhorzhevskaya, E Suglobova, V Samakhovets, P Surmont, H A Ramírez Reyes, M Winter, F Prunier, B Cavert, B Salaun, J M Roca Catalán, A Beinhauer, Ian Ford, K Elsby, V Knyazeva, C Tamburino, V Khoury, A Felice Castro Issa, B Marchenko, K König, A Kennedy, J M Alegret Colomer, T Gillet, Clarify Investigators, B Maheu, A Troncoso Gil, N Haldane, B Koujan, T Mouhat, A Waldman, J Robert, J Campbell, A Kokis, M Micheals, P Gori, P Ramoutar, M Al Zaibag, V Ryzhkova, M Kazakovtseva, C Bernardeau, B Ferreiro Rodríguez, Y Voloshko, S Szabo, I Jarvis, Y N Ke, J Donetti, A Serrano-Garcia, R Ketelers, S Grigoryan, V Kulik, P Zündorf, L Kleemann, J McPherson, M Luaces Méndez, F Mouquet, L G Xiong, T H Tran, P Costello, A Potter, M Cinteza, F Colivicchi, E Nowicka, O Greiner, G Reddy, M Martins Oliveira, F Fernandes De Sousa, P Nocon, R Sewell, I Nikodemska, R Tadeu Munhoz, T Gilbert, I Laizane, M Maroun, B Demianiuk, A Bolidai, R Kacorzyk, R Fernández Mouzo, K Karastanev, J Blanco Castiñeiras, P Messali, R Schwarz, M Vardhani, O Gouli, C Thelemann, A Forclaz, G Khaznadar, G Eisele, P Sosner, M L Bourachot, N Pontikakis, S Heinemann-Meerz, E Zatsarina, E Smrckova, P Calmettes, D H Kang, M L Santos Iglesias, S M Marinescu, A Heap, Melnikova, N F Strathmore, S Tolpygina, M Yang, M Naisseh, E George, J Banach, E Delcoulx, E Teijeira Fernández, J Poles, P Saunders, S Haddad, T Q Luu, A Dhesi, O Prikolota, M Baar, P Lafontaine, C O'Dong, I Petropoulos, B-M Altevogt, D Warden, T De Backer, G Miñana Escrivá, T L Mai, U Schlesinger-Irsch, M M Gomaa, E Moksyuta, M Drexler, P Monteiro, P Grooterhorst, J Moolman, P McAlavey, J O'Shea, L P Quinn, F Crespo, K Srinivasa Reddy, T Shokina, Ellen M. Schmidt, M H Jeong, K Denef, A Pleskof, I Takács, Y Tikhonov, O Ushakov, L Stevens, J Ezcurdia Sasieta, L Nkombua, O Henne Otero, J Y Fraboulet, D S Kim, G Hoh, A Tamm, M Sardon, G Chatzioakim, M A Ulecia Martínez, S Reymond, M Myint, G Proença, R Massabie, E Foster, H Dougall, Anjan Kumar Roy, C Franco Aranda, M Getman, E Filippova, C Aguiar, X D Pu, N Voronina, L L Chen, M Szulc, L Bayakhchan, M J Pinto Vaz, C Niederberger, N Vites, I Sen, Paul R. Kalra, J A Castillo Moreno, W K Ng, C Brunschwig, D Morgan, A Concepción Clemente, N Yakimova, J M Guy, A H Jaafar, J Badarienė, N Taylor, L Compson, R Amor, A Maximovitch, J L Bardají Mayor, E Marín Araez, N H Chau, N Srtumilenko, K Kelly, A Papathanasioy, S Erofeev, B Mamez, A Ribeiro, M Micko, N Alvarenga Recalde, K Atueva, Z Sebõk, P Kycina, A K Gupta, A Laucevičius, R Ahuja, A Prokop, P Stadler, S De Ridder, L Zhang, F B Ramadan, L Kapustina, V Fedoskin, A Bateman, C A Nacht, R Musetescu, M Aparici Feal, A Büttl, S Ross, M Rau, P Federico Zaragoza, G Brisson, M Zagreanu, T T H Pham, F Dominé, N Davydova, N Petrochenko, N Paul, P H Truong, S Frickel, W Bryl, G Brouillette, A Stumpp, M Barrera Bustillos, C Ziccarelli, O Zalyzniak, M eatherhead, N Watkins, G Riccioni, l Kudryavtsev, R Carvalho, J P S Sawhney, V González Toda, P Matos Dias, M Giorgadze, I Rodriguez Marrero, W Gritsch, K Lee, G W Kellam, I Parker, V Ecina, Mª I Soto Ruiz, C Delhomme, T Ivaschenko, Y W Cheah, I Grudtsina, R Chehayeb, T Dookie, O Krasnoslobodskaya, P Jarmużek, F Van den Branden, A M F Vandeplas, A Rocha De Almeida, M Espiga De Macedo, E Łotocka, K Nagy, R Paliulionienė, J L Leyva Pons, N Fedorova, Y Yanina, O Stasuk, Z Vlasuk, P Lim, P Egloff, T Berezhna, A Faria, J Cerda Rojas, E Moser, H G Jin, S J Oh, G Arquero García, K H Karner, I Leontaridis, A Banikova, J Fridrich, H Lesseliers, I Pokrovskaya, P Astridge, H Abdul Manap, R Daniel, C A Almeida Fernández, A Nowowiejska-Wiewióra, B Carvalho De Moura, M Malden, H Rosenstein, S Dixon, G Balogh, M Adam-Blanpain, A Sandalian, H Gervas Pavón, G A Antoniadis, N Naberezhnova, A Amlaiky, P Terrosu, K K H Lau, B Chartier, X Su, O Kovyrshyna, G Beale, P Primot, M H Chen, S S Ramesh, R Chyrek, E Gómez Álvarez, J Rodríguez Collado, G Sibilio, R Jeremiasz, R Colin, C Lalla, G M Fullerton, M P Samal, H Thümmel, R P Patel, J Takhar, H M Kwon, T A Cieza Lara, F Magliari, J Morrell, M Rayo Gutiérrez, T L Orenstein-Lyall, H Choi, S Kulinich, A Aftab, A Wallace, B B Abdul Kareem, S Kwok, A Królak, A Grover, Laurent Fauchier, Mª J Pinilla Lozano, G Sengupta, D Paris, M Al Dhanki, J Milewski, F Petersen Aranguren, H Brufau Redondo, H Mayr, A Arias Mendoza, M Ducoudre, A Correia, J S Awtar Singh, P Aylward, E Brscic, J Du Plooy, J L Arenas León, G Silva Alves, L Sreenivasa Murthy, P Dendale, F La Varra, S Minkin, T Eggeling, A Jamiel, G Lebischak, E Andreev, T V A Tuong, V Chaithiraphan, O Duprez, S Higgins, F Chometon, Y Cottin, A Bonny, C Guyetand, J Matos, F Henpin Yue Cesena, L Polyaeva, M Drijfhout, J Toplak, G E Vertes, N F Wang, J Doucet, A K Trivedi, P Turek, G Chouinard, A Al Lawati, W Filip, F Kovar, T J Cha, A Belanger, H L Cong, J F Robert, D López Gómez, J L Sanz Rodríguez, H Simper, P Shetty, A Chukwu, E Bukanina, C Amoros Galito, H MacCowan, T T T Tran, A Singal, K C Vu, O Ismail, A Ardiaca Capell, P Bousquet, F Goss, Z Galeeva, Maxime Guenoun, B Rijavec, Z Lazerevic, A McCracken, A C Motoc, Y Sharapova, S Wright, A J Paule Sánchez, L Mainar Latorre, I Sirazov, X L Yang, S E Paget, G Berkenboom, J Markenvard, I Surovtseva, S K George, Matthias Simon, M L Fuantos Delgado, C Christoforidis, M Lagares Carballo, P Alvarez García, J Könemann, L Crawford, I Gonos, D Saulnier, E Szabó, L Ardouin, J Bhayat, F J Abardía Oliva, X Bernard, O Sirbu, P Boutsikos, N Khmelevskikh, E Tavlueva, P LeBouthillier, I Bourazanis, A Sequeira, M López Martínez, C P Paulus, R K M Bhaskaran, F Pellerin, B Brown, B Saleh, A Lacchè, R Sola Casado, E Kaźmierczak, M Weingrod, and G Vijayaraghavan
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medicine.medical_specialty ,Cardiac & Cardiovascular Systems ,Epidemiology ,LONG-TERM ,medicine.medical_treatment ,Chronic coronary syndromes ,Coronary Artery Disease ,Revascularization ,Ventricular Function, Left ,GLUCOSE ,MELLITUS ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Diabetes Mellitus ,Ethnicity ,Prevalence ,medicine ,Humans ,ARTERY-DISEASE ,Myocardial infarction ,Stroke ,RISK ,OUTCOMES ,Ejection fraction ,Science & Technology ,business.industry ,Proportional hazards model ,CLARIFY Investigators ,Hazard ratio ,Diabetes ,Stroke Volume ,Geographical disparities ,Syndrome ,medicine.disease ,MIDDLE-EAST ,EUROPEAN-SOCIETY ,Treatment Outcome ,MYOCARDIAL-INFARCTION ,Heart failure ,CLARIFY registry ,Cardiovascular System & Cardiology ,HEART-FAILURE ,Cardiology and Cardiovascular Medicine ,business ,Life Sciences & Biomedicine - Abstract
BackgroundIn contrast with the setting of acute myocardial infarction, there are limited data regarding the impact of diabetes mellitus on clinical outcomes in contemporary cohorts of patients with chronic coronary syndromes. We aimed to investigate the prevalence and prognostic impact of diabetes according to geographical regions and ethnicity.Methods and resultsCLARIFY is an observational registry of patients with chronic coronary syndromes, enrolled across 45 countries in Europe, Asia, America, Middle East, Australia, and Africa in 2009–2010, and followed up yearly for 5 years. Chronic coronary syndromes were defined by ≥1 of the following criteria: prior myocardial infarction, evidence of coronary stenosis >50%, proven symptomatic myocardial ischaemia, or prior revascularization procedure.Among 32 694 patients, 9502 (29%) had diabetes, with a regional prevalence ranging from below 20% in Northern Europe to ∼60% in the Gulf countries. In a multivariable-adjusted Cox proportional hazards model, diabetes was associated with increased risks for the primary outcome (cardiovascular death, myocardial infarction, or stroke) with an adjusted hazard ratio of 1.28 (95% confidence interval 1.18, 1.39) and for all secondary outcomes (all-cause and cardiovascular mortality, myocardial infarction, stroke, heart failure, and coronary revascularization). Differences on outcomes according to geography and ethnicity were modest.ConclusionIn patients with chronic coronary syndromes, diabetes is independently associated with mortality and cardiovascular events, including heart failure, which is not accounted by demographics, prior medical history, left ventricular ejection fraction, or use of secondary prevention medication. This is observed across multiple geographic regions and ethnicities, despite marked disparities in the prevalence of diabetes.ClinicalTrials identifierISRCTN43070564
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- 2021
21. IDF21-0047 Association between the advanced glycation end-products and the vascular complications in T1D – The DIABAGE study
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A.M. Diallo, S. Jaisson, R. Barriquand, C. Lukas, S. Barraud, B. Decoudier, M. Francois, S. Ly, C. Arndt, P. Nazeyrollas, P. Gillery, and B. Delemer
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Endocrinology ,Endocrinology, Diabetes and Metabolism ,Internal Medicine ,General Medicine - Published
- 2022
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22. Perugini score corelates with electrical and echographic structural abnormalities in transthyretine cardiac amyloïdosis
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J. Costa, R. Pouy, A. El Ali, N. Semaan, L. Bichon-Treulet, P. Nazeyrollas, and D. Metz
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Cardiology and Cardiovascular Medicine - Published
- 2022
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23. Prevalence of iron deficiency in cardiac rehabilitation
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J. Costa, C. Dolci, L. Bichon-Treulet, P. Nazeyrollas, and D. Metz
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Cardiology and Cardiovascular Medicine - Published
- 2022
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24. Cardiac rehabilitation in COVID-19 pandemic period
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J. Costa, I. Mouici, A. Maouche, P. Durdon, L. Bichon-Treulet, P. Nazeyrollas, and D. Metz
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Cardiology and Cardiovascular Medicine - Abstract
Background COVID-19 pandemic constitutes a challenge in cardiovascular disease management. Little is known about COVID-19 prevalence and incidence in cardiac rehabilitation (CR) programs. Aim To evaluate the prevalence and incidence of COVID-19 in patients undergoing CR in ambulatory setting. Methods From august to October 2020, all patients admitted in a single ambulatory CR program were screened for COVID-19 infection before and after CR, through naso-pharyngeal RT-PCR and serology assays before and after the CR. Number of patients was reduced from 9 to 4 in each group, 2 meters distancing respected, and all patients and staff had to wear surgical mask during sessions. Hand washing and material disinfection were systematic before and after each session for both patients and health professionals. Results Among the 81 patients included, 63 (76%) were male, mean age was 57 ± 11 years (Table 1). None (0%) had positive RT-PCR before entering CR and only 2 (2.7%) were tested positive after CR. These two patients were asymptomatic. After serological analysis, 3 patients (3.8%) had anti-bodies against SARS-COV-2 before and after participating CR (Fig. 1). These 3 patients were negative on nasal swab before and after CR. No seroconversion was observed. In total (before and after CR), 5 patients (6.0%) were tested positive with COVID-19. Those 5 patients were younger (mean age 51 years old versus 58, P = 0.02), with better functional capacity before and after CR: respectively 7.1 METs (versus 5.2 METs, P = 0.01) and 8.3 METs (versus 6.3 METs, P = 0.03). In COVID+ patients, improvement of functional capacity was similar to COVID–patients: respectively 0.8 METs (P = 0.9) and 15 Watts (P = 0.9). Conclusion CR is not associated with risk of infection with SARS-COV-2, provided that basic sanitary measures are stricly applied. It is also associated with functional capacity improvement, even in patients who previously had COVID-19.
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- 2021
25. Effects of amifostine on perfused isolated rat heart and on acute doxorubicin-induced cardiotoxicity
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Nazeyrollas, Pierre, Prévost, Alain, Baccard, Nathalie, Manot, Leslie, Devillier, Philippe, and Millart, Hervé
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- 1999
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26. No association of endothelial lipase and aldose reductase polymorphisms with proliferative diabetic retinopathy: Results of the French prospective multicenter REDIAGEN study.
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HENRY, Adrien, BOIGELOT, Tiffany, MOURA, Thomas FERREIRA DE, LECLERCQ, Isabelle, BARBE, Coralie, THIERY, Aurore, DJERADA, Zoubir, NAZEYROLLAS, Pierre, CLAVEL, Christine, CORNILLET-LEFEBVRE, Pascale, BERROD, Jean-Paul, CREUZOT-GARCHER, Catherine, MEYER, Laurent, GAUCHER, David, GUERCI, Bruno, LENOBLE, Patrick, MILAZZO, Solange, PERONE, Jean-Marc, ARNDT, Carl, and DURLACH, Vincent
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ALDOSE reductase ,DIABETIC retinopathy ,LIPASES - Published
- 2024
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27. Valeur pronostique à 12 mois du niveau de fragilité évalué par la grille SEGA dans le cadre du syndrome coronaire aigu de l’octogénaire : étude PROSECO
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Jean Luc Novella, P. Nazeyrollas, Laurent Faroux, Damien Jolly, Moustapha Dramé, C. Acsente, and D. Metz
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Epidemiology ,Public Health, Environmental and Occupational Health - Abstract
Etat de la question La grille SEGA a montre de bonnes performances dans le depistage de l’etat de fragilite aussi bien a domicile que dans les services d’accueil des urgences. Ses capacites predictives dans le cadre du syndrome coronaire aigu des sujets âges n’ont toutefois pas encore ete evaluees. L’objectif de notre etude etait d’etudier la valeur pronostique a 12 mois du niveau de fragilite evalue par la grille SEGA dans une population de patients âges de 80 ans ou plus hospitalises pour un syndrome coronaire aigu. Materiel et methodes Tous les patients consecutifs âges de 80 ans ou plus hospitalises pour un syndrome coronaire aigu de type 1 entre le 1er novembre 2016 et le 1er novembre 2017 etaient inclus. Ils beneficiaient d’une evaluation geriatrique standardisee incluant une estimation du niveau de fragilite par la grille SEGA. Le critere de jugement principal etait le delai jusqu’a la survenue d’un deces quelle qu’en soit la cause. Resultats Au total, 64 patients ont ete inclus avec un âge moyen de 85,3 ± 4 ans. Selon la grille SEGA, 24 % etaient « fragiles » et 44 % etaient « tres fragiles ». Dix-huit (28 %) deces ont ete observes au cours du suivi. Apres ajustement sur l’âge du patient, l’indice de masse corporelle et la presence d’une hypertension arterielle, la survie n’etait pas significativement liee a la fragilite (HR 1,1 ; 95 % CI 0,4 a 3,1 ; p = 0,8) ( Fig. 1 ). Conclusion La fragilite definie par la grille SEGA (fragilite physique et/ou psychique et/ou sociale) n’etait pas significativement liee au risque de deces dans notre population.
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- 2019
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28. P4538Therapeutic and prognostic impact of comprehensive geriatric assessment in elderly patients with infective endocarditis
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F. Delahaye, Bruno Hoen, C. Patry, Aepei, G. Sost, François Alla, Bernard Iung, Claire Roubaud-Baudron, L. Belle, P. Nazeyrollas, Emmanuel Forestier, Christine Selton-Suty, O. Pineau, Gaëtan Gavazzi, and T. Fraisse
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medicine.medical_specialty ,business.industry ,Infective endocarditis ,medicine ,Geriatric assessment ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business ,Intensive care medicine - Published
- 2017
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29. Prediction of cardiovascular events by left ventricular longitudinal deformation parameters after transcatheter aortic valve implantation
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Olivier Huttin, P. Nazeyrollas, and F. Heurtebize
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medicine.medical_specialty ,Ejection fraction ,Transcatheter aortic ,Longitudinal strain ,business.industry ,medicine.disease ,Basal (phylogenetics) ,Stenosis ,Internal medicine ,medicine ,Cardiology ,In patient ,Cardiology and Cardiovascular Medicine ,Longitudinal deformation ,business ,Cardiovascular mortality - Abstract
Background Transcatheter Aortic Valve Implantation (TAVI) is a recommended therapy for patients with severe aortic stenosis in surgically high or intermediate-risk patients but during follow-up, the rate of death and re-hospitalization for cardiovascular causes remains high. Purpose The objective of this study was to evaluate left ventricular global systolic longitudinal deformation before TAVI as predictors of prognosis after. Methods 146 patients treated by TAVI between 2015 and 2016 at Nancy Hospital and in 2016 at Reims Hospital were included. The parameters studied were the global longitudinal strain (GLS), the endocardial and epicardial strain, the basal and apical regional strain, and the post systolic index (PSI). The main endpoint was cardiovascular mortality. The secondary criteria were the occurrence of a cardiovascular hospitalization and the occurrence of one or the other. Results Despite a left ventricular ejection fraction conserved at 58.8 ± 10.6%, the GLS was impaired at −16.4 ± 4.1%. The cardiovascular death rate was 9.6% (14 patients). The GLS before TAVI was predictive of cardiovascular mortality for endocardial, medial and epicardial strain with thresholds of −17%, −15% and −13% respectively with Sensitivity (Se) 64% and Specificity (Sp) 70% (P = 0.01), Se 63% Sp 70% (P = 0.006), and Se 64% Sp 70%(P = 0.008) respectively. The rate of rehospitalization for cardiovascular cause was 16.4% (24 patients). PSI was also a factor of poor prognosis for cardiovascular hospitalizations with a threshold of 10, clinically relevant and usable (P = 0.029). Conclusion Left ventricular longitudinal deformation parameters are decreased in patients with severe aortic stenosis despite a conserved LVEF. They seem to have a prognostic value for the cardiovascular mortality rate and occurrence of cardiovascular re-hospitalization after TAVI. They may have an interest in defining the delay of the beginning of treatment and follow-up to maintain after TAVI.
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- 2019
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30. Association of endothelial lipase Thr111Ile polymorphism with proliferative retinopathy in type 2 diabetes patients
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I. Leclercq, I. Movesayan, P. Nazeyrollas, V. Durlach, C. Clavel, M.M. Malloy, John P. Kane, Clive R. Pullinger, A. Ducasse, E. Socquard, A. Durlach, and C. Arndt
- Subjects
Adult ,Male ,Endothelial lipase ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Type 2 diabetes ,Polymorphism, Single Nucleotide ,Gastroenterology ,Endocrinology ,Internal medicine ,Genotype ,Internal Medicine ,medicine ,Humans ,Genetic Predisposition to Disease ,Prospective cohort study ,Aged ,Retrospective Studies ,Aged, 80 and over ,Univariate analysis ,Diabetic Retinopathy ,business.industry ,Heterozygote advantage ,Lipase ,General Medicine ,Diabetic retinopathy ,Middle Aged ,medicine.disease ,Minor allele frequency ,Diabetes Mellitus, Type 2 ,Female ,business - Abstract
Aim Our previous study demonstrated that the endothelial lipase (EL) C.584C>T polymorphism (rs2000813, p.Thr111Ile) was significantly associated with diabetic retinopathy (DR). The present work was conducted to see if this specific variant of the EL gene was more specifically linked to the severity of DR. Methods This retrospective cohort study was based on a review of the institutional charts of 287 type 2 diabetes patients (mean age=59.7years; mean BMI=29.0kg/m 2 ; mean HbA 1c =8.4%) genotyped for the EL C.584C>T polymorphism (rs2000813, p.Thr111Ile). The stage of DR was also determined for each genotype (CC, CT, TT). Results On univariate analysis, the minor allele homozygote TT variant was significantly associated with severe DR (OR: 4.3; 95% CI: 1.4, 13.1) compared with the major CC homozygote. No significant result was found for the CT heterozygote. Multivariate analysis revealed an increased risk for TT homozygotes to present with severe non-proliferative DR (OR: 8.09; 95% CI: 1.23, 53.1) or proliferative DR. Other associations were not significant. Conclusion Minor allele homozygosity for this EL variant (c.584C>T) could be a significant risk factor for developing severe, sight-threatening disease due to proliferative DR. Further prospective studies of this EL polymorphism in a larger population sample are needed to confirm these results.
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- 2014
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31. Carcinoid heart disease (CHD): the CRUSOE-NETs, a prospective cohort study from the French group of endocrine tumours (GTE)
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L. Francois, C. Lombard Bohas, Eric Baudin, F. Delelis, Thomas Walter, Romain Coriat, A. Cachier, P. Nazeyrollas, O. Hentic Dhome, S. Dominguez, J.-C. Eicher, Guillaume Cadiot, L. Cabanes, S. Ederhy, C. Lepage, K. Dekeister Geoffroy, Pauline Afchain, and J. Forestier
- Subjects
medicine.medical_specialty ,Peptide receptor ,business.industry ,Incidence (epidemiology) ,Hematology ,Neuroendocrine tumors ,medicine.disease ,Aortic disease ,Clinical trial ,Oncology ,Internal medicine ,Radionuclide therapy ,medicine ,business ,Prospective cohort study ,Carcinoid syndrome - Abstract
Background Neuroendocrine tumors (NET) represent a heterogeneous group of rare tumors, some of them secreting serotonin resulting in the carcinoid syndrome (CS). CHD is an integral part of this syndrome but remains poorly understood. The GTE is conducting a national survey of patients at risk for CHD aiming at evaluating the occurrence & progression rates of CHD, the frequency & results of cardiac surgery, and patient outcomes as well as the role of clinical characteristics and biomarkers as predictive markers; 600 patients are expected over a 5-year period with a 10-year follow-up. We herein present the study status at one year. Methods Patients with a metastatic ileum or bronchial NET, or any NET with a CS or 5HIAA levels greater than at least twice the upper normal range, seen by a NET specialist and a referee cardiologist are eligible. Clinical, pathological, biological parameters and previous treatments are collected. A transthoracic echocardiography is realised at inclusion and at least every year. Results From March 2018 to March 2019, 167 patients from 8 centers were included. Median [range] time from NET diagnosis to study inclusion was 56 months [0-501]. Median age was 66 years [34-86] with a male preponderance (53%); 85% had ileum NETs, 8% lung NETs, and 7% other NETs with CS or elevated 5HIAA; 100% had metastatic disease. Most of them have been pretreated: somatostatin analogs 96%, surgery of primary tumor 81% or metastasis 34%, liver embolization 24%, peptide receptor radionuclide therapy 19%, chemotherapy 16%, targeted therapy 12%, radiofrequency ablation 6%, interferon 2%. At inclusion, 81 patients (49%) had a CS, 67% with flushing, 68% with diarrhea. CHD was documented in 22 (13%) patients, all of them had tricuspid disease and simultaneous pulmonary, mitral and/or aortic disease for respectively 13, 3 and 1 of them; 14 patients with CHD had a CS. Seven patients underwent cardiac surgery for CHD. Conclusions The first large prospective multicentric study about CHD is ongoing. Preliminary results confirm the feasibility of the study with nearly 170 patients included in one year and 13% of CHD. The inclusion of new patients and 10-year follow-up will allow a better knowledge of the current incidence, progression and prognosis of CHD. Clinical trial identification NCT03498040. Legal entity responsible for the study French Group of Endocrine Tumors (GTE). Funding IPSEN. Disclosure G. Cadiot: Advisory / Consultancy: Novartis; Advisory / Consultancy: Ipsen; Advisory / Consultancy: AAA; Advisory / Consultancy: Keocyt. P. Nazeyrollas: Honoraria (self), Honoraria (institution), Travel / Accommodation / Expenses, Non-remunerated activity/ies: Novartis; Honoraria (self), Non-remunerated activity/ies: MSD; Honoraria (institution): Sanofi; Honoraria (institution): novo-nordisk; Travel / Accommodation / Expenses, Non-remunerated activity/ies: actelion; Travel / Accommodation / Expenses, Non-remunerated activity/ies: Bayer; Non-remunerated activity/ies: Servier; Non-remunerated activity/ies: bms. P. Afchain: Travel / Accommodation / Expenses: Novartis; Travel / Accommodation / Expenses: Ipsen. F. Delelis: Honoraria (self): Novartis; Honoraria (self): boehringer. J. Forestier: Honoraria (self): Amgen; Honoraria (self), Advisory / Consultancy, Speaker Bureau / Expert testimony, Research grant / Funding (institution): Bayer; Honoraria (self), Speaker Bureau / Expert testimony, Research grant / Funding (institution): Ipsen; Honoraria (self), Advisory / Consultancy, Travel / Accommodation / Expenses: Sanofi; Honoraria (self), Advisory / Consultancy, Speaker Bureau / Expert testimony: Merck; Honoraria (self): Servier. C. Lombard Bohas: Advisory / Consultancy: Ipsen; Advisory / Consultancy: Novartis; Advisory / Consultancy: Pfizer; Advisory / Consultancy: AAA. All other authors have declared no conflicts of interest.
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- 2019
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32. Comparison of clinical outcomes after transcarotid and transsubclavian versus transfemoral transcatheter aortic valve implantation: A propensity-matched analysis.
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Villecourt, Aurélien, Faroux, Laurent, Muneaux, Alexandre, Tassan-Mangina, Sophie, Heroguelle, Virginie, Poncet, Anne, Nazeyrollas, Pierre, Ruggieri, Vito Giovanni, and Metz, Damien
- Abstract
Copyright of Archives of Cardiovascular Diseases is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2020
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33. Abdominal aorta tortuosity on computed tomography identifies patients at risk of complications during transfemoral transcatheter aortic valve replacement.
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Kinnel, Marine, Faroux, Laurent, Villecourt, Aurélien, Tassan-Mangina, Sophie, Heroguelle, Virginie, Nazeyrollas, Pierre, Poncet, Anne, Ruggieri, Vito Giovanni, and Metz, Damien
- Abstract
Copyright of Archives of Cardiovascular Diseases is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2020
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34. Embolies coronaires secondaires à un thrombus adhérent de l’oreillette droite par un foramen ovale perméable
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C. Ménager, P. Nazeyrollas, H.T. Bui, D. Metz, and S. Rubin
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medicine.medical_specialty ,Intracranial Embolism ,business.industry ,medicine.medical_treatment ,Mitral valve replacement ,medicine.disease ,Thrombosis ,Surgery ,Pulmonary embolism ,Paradoxical embolism ,Embolism ,cardiovascular system ,medicine ,Patent foramen ovale ,cardiovascular diseases ,Thrombus ,Cardiology and Cardiovascular Medicine ,business - Abstract
This observation relates to the discovery of native coronary paradoxical embolism secondary to thrombus adherent to the right atrium through a patent foramen ovale (PFO). A patient of 64 years, with a history of mitral regurgitation not followed, was hospitalized for acute respiratory distress due to a mitral insufficiency (MI) with a ruptured chordae and pulmonary embolism. Coronary angiography was performed and revealed two typical images of coronary embolism associated to a non-atheromatous coronary tree. The patient underwent a mitral valve replacement. After the establishment of cardiopulmonary bypass, adherent fibrin and cruoric thrombus of the right atrium and a PFO were found. The analysis of the valves did not reveal any arguments for infective endocarditis. A CT scan, performed as the patient remained unconscious after surgery, showed several cerebral infarcts. Paradoxical embolism coronary was diagnosed in front of the combination of adherent thrombus in the right atrium, pulmonary embolism and systemic coronary and cerebral embolism with a PFO. Coronary embolism rarely happens. It is mainly due to three causes: iatrogenic origin in most cases, direct causes due to micro emboli, particularly from infectious endocarditis and paradoxical embolic origin. There are two types of right atrial thrombus; the most common is the mobile thrombus from the peripheral venous system. The other one, which is more rare, is the adherent thrombus, which occurs in situ. Coronary embolism of paradoxical origin represents a small proportion of the causes of coronary embolism. However, this diagnosis must be considered.
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- 2013
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35. Vascular and systemic diseases: Use of transthoracic Doppler echocardiography combined with clinical and electrocardiographic data to predict acute pulmonary embolism
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Jolly D, Damien Metz, J. Elaerts, Chapoutot L, P. Nazeyrollas, Maes D, Maillier B, C. Jennesseaux, and J. P. Chabert
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Vascular disease ,Deep vein ,Respiratory disease ,Doppler echocardiography ,medicine.disease ,QT interval ,Thrombosis ,Pulmonary embolism ,medicine.anatomical_structure ,Internal medicine ,Cardiology ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,Electrocardiography - Abstract
Transthoracic echocardiography and continuous wave Doppler were prospectively performed in 132 out-patients with suspicion of pulmonary embolism, and who had no previous history of severe cardiac or pulmonary disease. Bedside echocardiography determined diagnosis other than pulmonary embolism in 55 patients. Further study was completed in 70 patients; pulmonary embolism was found in 31 and excluded in 39. Significant differences were found as regards right ventricular diameter (27 +/- 8 vs 22 +/- 5 mm, P < 0.001), left ventricular diameter (41 +/- 9 vs 49 +/- 7 mm, P < 0.001), right over left ventricular diameter ratio (0.67 +/- 0.23 vs 0.43 +/- 0.15, P < 0.0001), tricuspid regurgitant flow peak velocity (2.9 +/- 0.4 vs 2.4 +/- 0.7 m.s-1, P < 0.0001), and abnormal septum motion (12 vs 4, P < 0.01). Multivariate analysis of echocardiographic data included a tricuspid regurgitant flow peak velocity greater than 2.5 m.s-1 and a right over left ventricular diameter ratio greater than 0.5 in a logistic model (sensitivity 93%, specificity 81%). The combination of echocardiographic and non-echocardiographic data included the two previous echocardiographic variables, together with signs of deep vein thrombosis, a deep S wave in lead D1, and a Q wave in lead D3 on the electrocardiogram in a logistic model (sensitivity 96%, specificity 83%). It can be concluded that emergency echocardiography, alone or combined with clinical examination and electrocardiogram, satisfactorily predicts acute pulmonary embolism.
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- 1996
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36. [Coronary embolism due to an adherent right atrium thrombus through a patent foramen ovale]
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C, Ménager, H T, Bui, S, Rubin, P, Nazeyrollas, and D, Metz
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Male ,Intracranial Embolism ,Embolism ,Foramen Ovale, Patent ,Humans ,Mitral Valve Insufficiency ,Hemiplegia ,Thrombosis ,Cerebral Infarction ,Heart Atria ,Middle Aged ,Pulmonary Embolism ,Coronary Vessels - Abstract
This observation relates to the discovery of native coronary paradoxical embolism secondary to thrombus adherent to the right atrium through a patent foramen ovale (PFO). A patient of 64 years, with a history of mitral regurgitation not followed, was hospitalized for acute respiratory distress due to a mitral insufficiency (MI) with a ruptured chordae and pulmonary embolism. Coronary angiography was performed and revealed two typical images of coronary embolism associated to a non-atheromatous coronary tree. The patient underwent a mitral valve replacement. After the establishment of cardiopulmonary bypass, adherent fibrin and cruoric thrombus of the right atrium and a PFO were found. The analysis of the valves did not reveal any arguments for infective endocarditis. A CT scan, performed as the patient remained unconscious after surgery, showed several cerebral infarcts. Paradoxical embolism coronary was diagnosed in front of the combination of adherent thrombus in the right atrium, pulmonary embolism and systemic coronary and cerebral embolism with a PFO. Coronary embolism rarely happens. It is mainly due to three causes: iatrogenic origin in most cases, direct causes due to micro emboli, particularly from infectious endocarditis and paradoxical embolic origin. There are two types of right atrial thrombus; the most common is the mobile thrombus from the peripheral venous system. The other one, which is more rare, is the adherent thrombus, which occurs in situ. Coronary embolism of paradoxical origin represents a small proportion of the causes of coronary embolism. However, this diagnosis must be considered.
- Published
- 2011
37. Association of endothelial lipase Thr111Ile polymorphism with lipid metabolism and microvascular complications in type 2 diabetic patients
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John P. Kane, I. Movesayan, Clive R. Pullinger, Mary J. Malloy, Christian Zellner, C. Clavel, V. Durlach, A. Ducasse, P. Nazeyrollas, Bradley E. Aouizerat, E. Socquard, A. Durlach, Matrice extracellulaire et dynamique cellulaire - UMR 7369 (MEDyC), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), and Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Endothelial lipase ,Male ,medicine.medical_specialty ,Genotype ,Endocrinology, Diabetes and Metabolism ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Biology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Endocrinology ,Risk Factors ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,Genetic Predisposition to Disease ,Longitudinal Studies ,ComputingMilieux_MISCELLANEOUS ,030304 developmental biology ,Aged ,0303 health sciences ,Diabetic Retinopathy ,Polymorphism, Genetic ,Cholesterol ,Microcirculation ,Cholesterol, HDL ,Homozygote ,Lipid metabolism ,General Medicine ,Diabetic retinopathy ,Cholesterol, LDL ,Lipase ,Middle Aged ,medicine.disease ,Lipid Metabolism ,3. Good health ,chemistry ,Diabetes Mellitus, Type 2 ,lipids (amino acids, peptides, and proteins) ,Female ,Endothelium, Vascular ,Diabetic Angiopathies ,Lipoprotein ,Retinopathy ,Follow-Up Studies - Abstract
Aim Endothelial lipase (EL) is a key enzyme in lipid metabolism, and a polymorphism in the EL gene may be a candidate for modulating lipid parameters in type 2 diabetic (T2D) patients. Methods In 396 T2D patients (age: 59.5±10.7 years; BMI: 28.9±5.3kg/m 2 ; HbA 1c : 8.2±1.9%), the c.584C>T polymorphism (rs2000813, p.Thr111Ile) was studied in 225 men (frequency of c.584T: 0.351) and 171 women (frequency of c.584T: 0.304). Patients' metabolic parameters, and macrovascular and microvascular complications, were assessed at baseline and at follow-up (mean: 4.2 years). Results Patients who were homozygous for the minor allele displayed modestly decreased low-density lipoprotein (LDL) cholesterol and raised apolipoprotein B at baseline, and raised systolic blood pressure and high-density lipoprotein (HDL) cholesterol on follow-up. Homozygosity for the minor allele was significantly associated with frequency of retinopathy ( P =0.025), with TT homozygous patients more likely to have diabetic retinopathy (OR: 3.505; 95% CI: 1.491–8.239) both initially and at follow-up. Conclusion The c.584C>T EL polymorphism is associated with a higher risk of diabetic retinopathy that could be linked to modifications in HDL-cholesterol metabolism and blood pressure levels.
- Published
- 2011
38. Association of HindIII and PvuII genetic polymorphisms of lipoprotein lipase with lipid metabolism and macrovascular events in type 2 diabetic patients
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V. Durlach, C. Clavel, P. Nazeyrollas, E. Socquard, and A. Durlach
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Male ,medicine.medical_specialty ,Site-Specific DNA-Methyltransferase (Adenine-Specific) ,DNA-Cytosine Methylases ,Endocrinology, Diabetes and Metabolism ,Lipoproteins ,Coronary Disease ,Type 2 diabetes ,Diabetic angiopathy ,Biology ,HindIII ,Endocrinology ,Risk Factors ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Triglycerides ,Aged ,Lipoprotein lipase ,Polymorphism, Genetic ,medicine.diagnostic_test ,nutritional and metabolic diseases ,Lipid metabolism ,General Medicine ,Middle Aged ,medicine.disease ,Lipids ,Lipoprotein Lipase ,Diabetes Mellitus, Type 2 ,Multivariate Analysis ,biology.protein ,lipids (amino acids, peptides, and proteins) ,Female ,Lipid profile ,Diabetic Angiopathies ,Lipoprotein - Abstract
Lipoprotein lipase (LPL) is a key enzyme of lipid metabolism, and its genetic polymorphism may be a candidate for modulating lipid parameters in type 2 diabetic subjects (D2).In a group of 404 type 2 diabetic patients, aged 59.5+/-10.8y, BMI=28.9+/-5.3 kg/m2, HbA1c=8.2+/-1.9%, we studied the H and P polymorphisms at the LPL locus detectable with the restriction enzymes HindIII and PvuII. Patients were separated into 229 males (17H1H1, 84H1H2, 128H2H2 and 51P1P1, 110P1P2, 68P2P2) and 175 females (16H1H1, 69H1H2, 90H2H2 and 51P1P1, 85P1P2, 39P2P2), and compared on the basis of their lipid parameters and their macrovascular complications.Triglyceride (TG) and HDL-cholesterol(c) concentrations differed between patients with and without coronary heart disease (CHD) (3.44+/-2.09 and 1.96+/-1.40 mmol/l for TGs and 1.05+/-0.24 and 1.34+/-0.40 mmol/l for HDL-c, P0.001). HDL-c concentrations were lower in male H2H2 and P2P2 subjects (P0.001), and TG levels were higher in male H2H2 and P2P2 subjects (P0.0001 for Hind III and P0.05 for PvuII). Allele frequency of the HindIII and PvuII restriction site was similar to those reported in other Caucasian populations and the presence of the H2/P2 variants was significantly higher in CHD patients. The prevalence of CHD in this population was 18% but was 29% in H2H2 and 38% in P2P2 subjects (P0.02).Thus, HindIII and PvuII polymorphisms seem to exert a modulating role on lipid profile particularly in male D2, contributing to increase the risk of macrovascular events.
- Published
- 2006
39. Risk Factors for Adverse Drug Reactions in Older Subjects Hospitalized in a Dedicated Dementia Unit.
- Author
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Kanagaratnam, Lukshe, Dramé, Moustapha, Novella, Jean-Luc, Trenque, Thierry, Joachim, Clarisse, Nazeyrollas, Pierre, Jolly, Damien, and Mahmoudi, Rachid
- Abstract
Objective To identify risk factors for the occurrence of adverse drug reactions (ADRs) based on geriatric evaluation. Design Longitudinal prospective study from May 2010 to November 2011. Setting Dedicated acute geriatric care unit specializing in the management of patients with dementia syndrome (Alzheimer disease or related syndromes) at the University Hospital of Reims, France. Participants Older patients with dementia syndrome (Alzheimer disease or related syndromes). Measurements Sociodemographic variables and comprehensive geriatric assessment were recorded. Occurrence of ADRs was noted. Risk factors for ADR were identified by multivariate logistic regression. Results During the study period, 293 patients were included; average age was 82 ± 8 years; the majority were women (61.4%). Average Mini-Mental State Examination score was 13 ± 8; average activities of daily living (ADL) score was 3.6 ± 2.1. Independent risk factors for occurrence of at least one ADR were polypharmacy (≥5 drugs/day) (OR: 4.0, 95% CI: 1.1--14.1) and dependence on at least 1 ADL (OR: 2.6, 95% CI: 1.1--6.5). Conclusions Risk factors for ADRs were polypharmacy and dependence on at least one ADL. Our findings underline the importance of taking into consideration the characteristics of the patients when prescribing drugs in this specific population. Prescriptions should be re-evaluated at each follow-up [ABSTRACT FROM AUTHOR]
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- 2017
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40. Echocardiographic assessment of right ventricular function and right ventriculoarterial coupling in tricuspid regurgitation.
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Trousselle, L., Eggenspieler, F., Faroux, L., Nazeyrollas, P., Huttin, O., Pace, N., Filippetti, L., Fraix, A., Carquin, B., Selton-Suty, C., and Metz, D.
- Abstract
Echographic evaluation of the cardiopulmonary unit may be difficult in the presence of TR. Purpose: To assess the variation of simple and combined echographic parameters analysing the cardiopulmonary unit according to the severity of TR. Echographic images were reviewed in 179 patients to assess TR grade according to Hahn's 5 grades classification. Classical morphological (RV end diastolic length and area), function [TAPSE, RVFAC, S',RVFWS (RV free wall longitudinal strain)] and load [PASP,TRTVI (TR Time-velocity integral)] parameters analysing RV were assessed. Combined parameters of function and load (TAPSE/PASP, TR TVI × RVFWS), morphology and load (load adaptation index = TRTVIxRVED length/area) and morphology, load, and function [myomechanical index (MMI = RV-RA mean pressure gradient × RVFWS/indexed RAED area × 10–2) and morphology-load-function index (MLF = RVED length/area xTRTVIx RVFWS)] were calculated. We used ROC curves to analyze the diagnostic value of echocardiographic parameters to predict potential high (> 3) or low (< 6) surgical risk of mortality according to TRISCORE. Simple parameters were significatively different among groups with a nonlinear progression between the 5 levels of TR. Combined parameters were also significatively different. Among them, MMI and MLF had a linear progression (MMI: grade 1: 0.20 ± 0.09; grade 2: 0.15 ± 0.08; grade 3: 0.10 ± 0.05, grade 4: 0.09 ± 0.08; grade 5: 0.05 ± 0.04 P = 0.000; MLF: grade 1: 7.56 ± 2.06; grade 2: 6.57 ± 2.14; grade 3: 4.85 ± 2.29, grade 4: 4.79 ± 3.17; grade 5: 3.06 ± 1.82 P = 0.000) and had the best predictive value for TRISCORE (MMI: AUC = 0.889 P = 0.000 for low risk, 0.855 P = 0.000 for high risk; MLF: AUC = 0.873 P = 0.000 and 0.822 P = 0.000). Combined parameters are relevant to evaluate cardiopulmonary unit in a population presenting with TR, especially when combining morphology, function and load (Fig. 1). [ABSTRACT FROM AUTHOR]
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- 2023
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41. Efficiency of amifostine as a protection against doxorubicin toxicity in rats during a 12-day treatment
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P, Nazeyrollas, C, Frances, A, Prevost, B, Costa, M, Lorenzato, J P, Kantelip, J, Elaerts, and H, Millart
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Male ,Amifostine ,Antibiotics, Antineoplastic ,Doxorubicin ,Body Weight ,Animals ,Drug Interactions ,Heart ,In Vitro Techniques ,Rats, Wistar ,Myocardial Contraction ,Ventricular Function, Left ,Rats - Abstract
Our purpose was to determine the effects of amifostine, a cytoprotective agent, on doxorubicin tolerance and cardiotoxicity in rats.Male Wistar rats were treated every other day with an intraperitoneal injection of amifostine or saline 30 minutes before intraperitoneal injection of doxorubicin or saline. Weight change was recorded, and contractile function was evaluated after 11 injections by means of the isolated heart.Weight evolution and cardiac function were significantly improved by 7 and 20 mg/kg amifostine (p0.001) but not by 50 mg/kg. The final weight were: controls 349 +/- 16 g; doxorubicin alone 258 +/- 54 g; with amifostine: 7 mg/kg 314 + 28 g; 20 mg/kg 312 +/- 32 g; 50 mg/kg 250 +/- 34 g. Left ventricular developed pressure were: controls 137 +/- 15 mmHg; doxorubicin alone 119 +/- 20 mmHg; with amifostine: 7 mg/kg 140 +/- 20 mmHg; 20 mg/kg 137 +/- 25 mmHg; 50 mg/kg 124 +/- 20 mmHg.Seven and 20 mg/kg amifostine protected rats from the toxicity of doxorubicin at the cumulative dose of 18 mg/kg during a 12-day treatment, with regard to weight loss and heart contraction.
- Published
- 2003
42. [Stress cardiomyopathy: report of 2 cases]
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A, Aliouche, C, Pop, L, Chapoutot, S, Tassan, E, Vautrin, P, Nazeyrollas, and D, Metz
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Catecholamines ,Humans ,Female ,Middle Aged ,Cardiomyopathies ,Stress, Psychological - Abstract
The authors reported two cases of acute catecholamines cardiomyopathy expressed clinically by chest pain and dyspnea, without any previous cardiac history. The diagnosis of human stress cardiomyopathy is established on: typically rapid onset aftermath of intense emotional stress, left ventricular apical akinesis and hyperkinetic motion of basal walls imaged by two-dimensional echocardiography. Rapid reversal clinical course and normal coronary arteriography. Similar finding have been observed in conjunction with pheochromocytoma who have been excluded by normal levels of urinary catecholamines metabolites.
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- 2003
43. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry
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Sawhney, Jitendra PS., Kothiwale, Veerappa A., Bisne, Vikas, Durgaprasad, Rajashekhar, Jadhav, Praveen, Chopda, Manoj, Vanajakshamma, Velam, Meena, Ramdhan, Vijayaraghavan, Govindan, Chawla, Kamaldeep, Allu, Jagan, Pieper, Karen S., John Camm, A., Kakkar, Ajay K., Kakkar, Ajay K., Bassand, Jean-Pierre, John Camm, A., Fitzmaurice, David A., Goldhaber, Samuel Z., Goto, Shinya, Haas, Sylvia, Hacke, Werner, Mantovani, Lorenzo G., Misselwitz, Frank, Pieper, Karen S., Turpie, Alexander G.G., van Eickels, Martin, Verheugt, Freek W.A., John Camm, A., Bassand, Jean-Pierre, Goldhaber, Samuel Z., Haas, Sylvia, Kayani, Gloria, Mantovani, Lorenzo G., Fox, Keith A.A., Gersh, Bernard J., Luciardi, Hector Lucas, Gibbs, Harry, Brodmann, Marianne, Cools, Frank, Barretto, Antonio Carlos Pereira, Connolly, Stuart J., Spyropoulos, Alex, Eikelboom, John, Corbalan, Ramon, Hu, Dayi, Jansky, Petr, Nielsen, Jørn Dalsgaard, Ragy, Hany, Raatikainen, Pekka, Le Heuzey, Jean-Yves, Darius, Harald, Keltai, Matyas, 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Fitzmaurice, D., Chauhan, N., Goodwin, D., Saunders, P., Evans, R., Leese, J., Jhittay, P.S., Ross, A., Kainth, M.S., Pickavance, G., McDonnell, J., Williams, A., Gooding, T., Wagner, H., Suryani, S., Singal, A., Sircar, S., Bilas, R., Hutchinson, P., Wakeman, A., Stokes, M., Paul, N., Aziz, M., Ramesh, C., Wilson, P., Franklin, S., Fairhead, S., Thompson, J., St Joseph, V., Taylor, G., Tragen, D., Seamark, D., Paul, C., Richardson, M., Jefferies, A., Sharp, H., Jones, H., Giles, C., Page, M., Oginni, O., Aldegather, J., Wetherwell, S., Lumb, W., Evans, P., Scouller, F., Macey, N., Stipp, Y., West, R., Thurston, S., Wadeson, P., Matthews, J., Pandya, P., Gallagher, A., Railton, T., Sinha, B., Russell, D., Davies, J.A., Ainsworth, P., Jones, C.P., Weeks, P., Eden, J., Kernick, D., Murdoch, W., Lumley, L., Patel, R.P., Wong, S.W., Saigol, M., Ladha, K., Douglas, K., Cumberlidge, D.F., Bradshaw, C., Van Zon, G., Jones, K.P., Thomas, M.J., Watson, E., Sarai, B., Ahmad, N., Willcock, W., Cairns, J., Sathananthan, S., de Kare-Silver, N., Gilliland, A., Strieder, E., Howitt, A., Vishwanathan, B., Bird, N., Gray, D., Evans, P., Clark, M., Bisatt, J., Litchfield, J., Fisher, E., Fooks, T., Kelsall, A.R., Alborough, E., Wakeling, J., Parfitt, M., Milne, K., Rogers, S., Priyadharshan, R., Oliver, J.L., Davies, E., Abushal, S., Jacobs, M., Hutton, C., Walls, N.I., Thompson, R., Chigbo, C., Zaidi, S.M.A., Howard, M., Butter, K.C., Barrow, S., Little, H., Haq, I.U., Gibbons, L., Glencross, S., McLeod, A.J., Poland, K., Mulholland, C., Warke, A., Conn, P., Burns, G., Smith, R.N., Lowe, S., Kamath, R., Dau, H.S., Webster, J., Hodgins, I., Vercoe, S., Roome, P.C., Pinnock, H., Patel, J.R.A., Ali, A., Hart, N., Davies, R., Stuart, E., Neden, C.A., Danielsen, M., Heath, R., Sharma, P., Galloway, S., Hawkins, C., Oliver, R., Aylward, M., Mannion, S., Braddick, M., Edwards, D., Rothwell, A.C., Sabir, A., Choudhary, F., Khalaque, S., Wilson, A., Peters, S., Coulson, W., Roberts, N., Heer, A., Coates, S., Ward, B., Jackson, D., Walton, S., Shepherd, D., Sterry, M., Wong, T., Boon, M., Bunney, R., Haria-Shah, R., Baron, R.T., Davies, S., Schatzberger, T., Hargreaves, N., Stephenson, T., Choi, H., Batson, R., Lucraft, L., Myhill, T., Estifano, S., Geatch, D., Wilkinson, J., Veale, R., Forshaw, K., Davies, T., Zaman, K., Vinson, P., Liley, C., Bandrapalli, M., McGinty, P., Wastling, R., McEleny, P., Beattie, A., Cooke, P., Wong, M., Gunasegaram, J., Pugsley, M., Ahmad, S., A'Court, C., Ayers, J., Bennett, J., Cartwright, S., Dobson, S., Dooldeniya, C., Flynn, A., Fox, R., Goram, J., Halpin, A., Hay, A., Jacobs, P., Jeffers, L., Lomax, L., Munro, I., Muvva, R., Nadaph, M., Powell, K., Randfield, S., Redpath, D., Reed, R., Rickenbach, M., Rogers, G., Saunders, P.B., Seamark, C., Shewring, J., Simmons, P., Simper, H., Stoddart, H., Sword, A., Thomas, N., Thomson, A., Gibbs, H., Blenkhorn, A., Singh, B., Van Gaal, W., Abhayaratna, W., Lehman, R., Roberts-Thomson, P., Kilian, J., Coulshed, D., Catanchin, A., Colquhoun, D., Kiat, H., Eccleston, D., French, J., Zimmett, L., Ayres, B., Phan, T., Blombery, P., Crimmins, D., O'Donnell, D., Choi, A., Astridge, P., Arstall, M., Jepson, N., Binnekamp, M., Lee, A., Rogers, J., Starmer, G., Carroll, P., Faunt, J., Aggarwala, A., Barry, L., Batta, C., Beveridge, R., Black, A., Bonner, M., Boys, J., Buckley, E., Campo, M., Carlton, L., Connelly, A., Conway, B., Cresp, D., Dimitri, H., Dixon, S., Dolman, M., Duroux, M., Eskandari, M., Eslick, R., Ferreira-Jardim, A., Fetahovic, T., Fitzpatrick, D., Geraghty, R., Gibbs, J., Grabek, T., Modi, M.H., Hayes, K., Hegde, M.P., Hesketh, L., Hoffmann, B., Jacobson, B., Johnson, K., Juergens, C., Kassam, I., Lawlor, V., Lehman, M., Lehman, S., Leung, D., Mackay, S., MacKenzie, M., McCarthy, C., McIntosh, C., McKeon, L., Morrison, H., Mussap, C., Myers, J.-D., Nagalingam, V., Oldfield, G., O'May, V., Palmer, J., Parsons, L., Patching, K., Patching, T., Paul, V., Plotz, M., Preston, S., Rashad, H., Ratcliffe, M., Raynes, S., Rose, J., Sanders, L., Seremetkoska, M., Setio, H., Shone, S., Shrestha, P., Singh, C., Singleton, C., Stoyanov, N., Sutcliffe, S., Swaraj, K., Tarrant, J., Thomas, N., Thompson, S., Tsay, I.M., Vorster, M., Waldman, A., Wallis, L., Wilford, E., Wong, K., Connolly, S.J., Spyropoulos, A., Eikelboom, J., Luton, R., Gupta, M., Pandey, A.S., Cheung, S., Leader, R., Beaudry, P., Ayala-Paredes, F., Berlingieri, J., Heath, J., Poirier, G., Du Preez, M., Nadeau, R., Dresser, G., Dhillon, R., Hruczkowski, T., Schweitzer, B., Coutu, B., Angaran, P., MacDonald, P., Vizel, S., Fikry, S., Parkash, R., Lavoie, A., Cha, J., Ramjattan, B., Bonet, J., Ahmad, K., Angaran, P., Aro, L., Aves, T., Beaudry, K., Bergeron, C., Bergeron, C., Bigcanoe, J., Bignell, N., Breakwell, L., Burke, E., Carroll, L., Clarke, B., Cleveland, T., Daheb, S., Dehghani, P., Denis, I., Djaidani, Z., Dorian, P., Douglass, S., Dunnigan, J., Ewert, A., Farquhar, D., Fearon, A., Ferleyko, L., Fournier, D., Fox, B., Grenier, M.-C., Gulliver, W., Haveman, K., Hines, C., Hines, K., Jackson, A.M., Jean, C., Jethoo, G., Kahlon, R., Kelly, S., Kim, R., Korley, V., Kornder, J., Kwan, L., Largy, J., Lewis, C., Lewis, S., Mangat, I., Moor, R., Navratil, J., Neas, I., Otis, J., Otis, R., Pandey, M., Petrie, F., Pinter, A., Raines, M., Roberts, P., Robinson, M., Sas, G., Schulman, S., Snell, L., Spearson, S., Stevenson, J., Trahey, T., Wong, S., Wright, D., Ragy, H., Abd El-Aziz, A., Abou Seif, S.K., El Din, M.G., El Etriby, S., Elbahry, A., El-Etreby, A., Elkhadem, M., Katta, A., Khairy, T., Mowafy, A., Nawar, M., Ohanissian, A., Reda, A., Reda, M., Salem, H., Sami, N., Samir, S., Setiha, M., Sobhy, M., Soliman, A., Taha, N., Tawfik, M., Zaatout, E., Jacobson, B., Kettles, D., Bayat, J., Siebert, H., Horak, A., Kelfkens, Y., Garda, R., Pillay, T., Guerra, M., van Zyl, L., Theron, H., Murray, A., Louw, R., Greyling, D., Mntla, P., Ueckermann, V., Loghdey, R., Ismail, S., Ahmed, F., Engelbrecht, J., Ramdass, A., Maharajh, S., Oosthuysen, W., Angel, G., Bester, C., Booysen, M., Boshoff, C., Cannon, C., Cassimjee, S., Chami, C., Conway, G., Davids, A., de Meyer, L., Du Plessis, G., Ellis, T., Henley, L., Karsten, M., Loyd, E., Marks, J., Mavhusa, L., Mostert, M., Page, A., Rikhotso, L., Salie, M., Sasto, J., Shaik, F., Skein, A., Smith, L., Tarr, G., Tau, T., van Zyl, F., Al Mahmeed, W., Yousef, G., Agrawal, A., Nathani, M., Ibrahim, M., Esheiba, E.M., Singh, R., Naguib, A., Abu-Mahfouz, M., Al Omairi, M., Al Naeemi, A., Maruthanayagam, R., Bazargani, N., Wassef, A., Gupta, R., Khan, M., Subbaraman, B., Abdul, A., Al Mulla, A., El Bardisy, S., Haridas, P., Jadhav, S., Magdaluyo, K., Makdad, M., Maqsood, I., Mohamed, R., Sharma, N., Sharma, R., Thanzeel, M., Goldhaber, S.Z., Canosa, R., Rama, P., Blumberg, E., Garcia, J., Mullen, P., Wilson, V., Quick, A., Ferrick, K., Kutayli, W.M., Cox, M., Franco, M., Falkowski, S., Mendelson, R., Williams, M., Miller, S., Beach, S., Sharma, N., Alfieri, A., Gutowski, T., Haque, I., Reddy, R., Ahmed, W., Delafontaine, P., Diercks, D., Theodoro, D., Remmel, K., Alberts, M., Ison, R., Noveck, H., Duffy, P., Pitta, S., Nishijima, D., Treasure, C., Asafu-Adjaye, N., Ball, K., Bartlett, M., Bentley, M., Bowers, S., Brown, A., Browne, A., Cameron-Watts, J., Canova, M., Cassidy, D., Cervellione, K., Congal, S., DePauw, J., Dickerson, A., Eley, M., Evans, L., Felpel, S., Ferdinand, K., Fielder, D., Gentry, P., Haideri, A., Hakimi, F., Harbour, T., Hartranft, E., Hawkins, B., Headlee, M., Henson, L., Herrick, C., Hicks, T., Jasinski, S., Johnson, K., Jones, A., Jones, L., Jones, P., Karl, S., Keeling, M., Kerr, J., Knowles, P., Langdon, J., Lay, M., Lee, J.A., Lincoln, T., Malone, E., Merliss, A., Merritt, D., Minardo, J., Mooso, B., Orosco, C., Palumbo, V., Parker, M., Parrott, T., Paserchia, S., Pearl, G., Peterson, J., Pickelsimer, N., Purcell, T., Raynor, J., Raziano, S., Richard, C., Richardson, T., Robertson, C., Sage, A., Sanghera, T., Shaw, P., Shoemaker, J., Smith, K., Stephanie, B., Thatcher, A., Theobald, H., Thompson, N., Treasure, L., Tripti, T., Verdi, C., and Worthy, V.
- Abstract
The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry.
- Published
- 2018
- Full Text
- View/download PDF
44. Practical management of concomitant acute heart failure and worsening renal function in the emergency department
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Ferreira, João Pedro, Chouihed, Tahar, Nazeyrollas, Pierre, Levy, Bruno, Seronde, Marie F., Bilbault, Pascal, Braun, François, Roul, Gérald, Kénizou, David, Zannad, Noura, Girerd, Nicolas, and Rossignol, Patrick
- Abstract
Worsening renal function (i.e. any increase in creatinine or decrease in the estimated glomerular filtration rate) is common in patients admitted for acute heart failure in the emergency department. Although worsening renal function (WRF) has been associated with the occurrence of dismal outcomes, this only appears to be the case when associated with clinical deterioration. However, if the clinical status of the patient is improving, a certain increase in serum creatinine may be acceptable. This WRF, which is not associated with clinical deterioration or adverse outcomes (e.g. during treatment up-titration), has been referred to as ‘pseudo-WRF’ and should not detract clinicians from targeting ‘guideline-recommended’ therapies. This is an important message for emergency physicians to pursue diuretics as long as signs of pulmonary congestion persist to improve the clinical status of the patient. In the present review, we aim to provide clinicians in acute settings with an integrative and comprehensive approach to cardiorenal interactions in acute heart failure.
- Published
- 2018
- Full Text
- View/download PDF
45. Integrative Assessment of Congestion in Heart Failure Throughout the Patient Journey
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Girerd, Nicolas, Seronde, Marie-France, Coiro, Stefano, Chouihed, Tahar, Bilbault, Pascal, Braun, François, Kenizou, David, Maillier, Bruno, Nazeyrollas, Pierre, Roul, Gérard, Fillieux, Ludivine, Abraham, William T., Januzzi, James, Sebbag, Laurent, Zannad, Faiez, Mebazaa, Alexandre, and Rossignol, Patrick
- Abstract
Congestion is one of the main predictors of poor patient outcome in patients with heart failure. However, congestion is difficult to assess, especially when symptoms are mild. Although numerous clinical scores, imaging tools, and biological tests are available to assist physicians in ascertaining and quantifying congestion, not all are appropriate for use in all stages of patient management. In recent years, multidisciplinary management in the community has become increasingly important to prevent heart failure hospitalizations. Electronic alert systems and communication platforms are emerging that could be used to facilitate patient home monitoring that identifies congestion from heart failure decompensation at an earlier stage. This paper describes the role of congestion detection methods at key stages of patient care: pre-admission, admission to the emergency department, in-hospital management, and lastly, discharge and continued monitoring in the community. The multidisciplinary working group, which consisted of cardiologists, emergency physicians, and a nephrologist with both clinical and research backgrounds, reviewed the current literature regarding the various scores, tools, and tests to detect and quantify congestion. This paper describes the role of each tool at key stages of patient care and discusses the advantages of telemedicine as a means of providing true integrated patient care.
- Published
- 2018
- Full Text
- View/download PDF
46. PO21 Le polymorphisme Thr111Ile de la lipase endotheliale : un nouveau biomarqueur de la sévérité de la rétinopathie chez le diabétique de type 2
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Christian Zellner, V. Durlach, A. Ducasse, I. Movesayan, Clive R. Pullinger, C. Arndt, Mary J. Malloy, I. Leclercq, John P. Kane, P. Nazeyrollas, C. Clavel, A. Durlach, and Bradley E. Aouizerat
- Subjects
Endocrinology ,Endocrinology, Diabetes and Metabolism ,Internal Medicine ,General Medicine - Abstract
Introduction L’identification de nouveaux facteurs de risque de gravite de retinopathie diabetique (RD) constitue un enjeu important, compte-tenu de la menace que celle-ci fait peser sur la fonction visuelle. La lipase endotheliale (LE) est une phospholipase qui joue un role important dans le metabolisme des HDL. Nous avons deja montre que le polymorphisme Thr111Ile (rs 2000813) de la LE s’associait particulierement a la RD sans prejuger de sa severite (Diabetes Metab 2011; 37(1):64-71). Patients et methodes Dans cette etude nous avons evalue retrospectivement dans un groupe de 287 patients diabetiques de type 2 (DT2) (âge = 59,7 ± 10,3 ans, BMI = 29,0 ± 5,5 kg/m 2 , HbA1C = 8,4 ± 1,9 %, duree du diabete = 12,0 ± 7,9 ans lors de la visite initiale) la severite de la RD en fonction du polymorphisme Thr11Ileu de la LE. Chaque dossier a ete revu, les patients classes en fonction de leur genotype (CC, CT, TT) et du stade de gravite de la RD. Resultats Les sujets homozygotes pour l’allele rare (TT) presentaient en analyse univariee une association significative avec les formes avancees de RD (severes non proliferantes, proliferantes, panphotocoagulees) (OR 4,3 IC95 % [1,4; 13,1]) en comparaison des sujets porteurs de l’allele frequent (CC). Le genotype CT etait sans effet particulier sur l’expression de la RD. Les facteurs predictifs de RD etaient dans ce groupe : le genotype TT (p = 0,03), la duree du diabete (p = 0,01), l’HbA1c (p Conclusion Le polymorphisme Thr111Ile de la lipase endotheliale (rs 2000813) s’associe significativement a un surcroit de risque de RD severe. Ces resultats devront etre confirmes sur de plus larges cohortes et les mecanismes physiopathologiques analyses.
- Published
- 2012
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47. [Value of pulsed Doppler tissue imaging for early detection of myocardial dysfunction with anthracyclines]
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S, Tassan-Mangina, C, Brasselet, P, Nazeyrollas, M, Collot-Bigot, B, Costa, A M, Blaise, P, Laury, L, Bonfils, D, Metz, and J, Elaerts
- Subjects
Adult ,Male ,Heart Diseases ,Heart Ventricles ,Ultrasonography, Doppler ,Echocardiography ,Heart Rate ,Ultrasonography, Doppler, Pulsed ,Neoplasms ,Humans ,Mitral Valve ,Anthracyclines ,Female ,Prospective Studies - Abstract
The cumulative and definitive nature of chronic cardiotoxicity of anthracyclines requires a preventive strategy of early diagnosis. The authors undertook a prospective study of the association of echocardiography, mitral Doppler and pulsed Doppler tissue imaging of the left ventricular lateral and posterior walls in the context of this problem in 20 patients without cardiac disease undergoing cancer chemotherapy including anthracyclines. Doppler echocardiography was performed before the first session of chemotherapy and at the end of treatment, 6 +/- 4 months later. After a total cumulative dose of 227 +/- 91 mg/m2 of doxorubicine, there were no changes in left ventricular ejection fraction but a significant decrease in mitral E wave velocity (p = 0.04) and in E/A ratio (p = 0.01), suggesting early changes in left ventricular relaxation. The Doppler tissue examination confirmed the presence of radial and longitudinal abnormalities in myocardial relaxation (decreases in myocardial E wave velocities of the posterior and lateral walls of the left ventricle, p = 0.02 and p = 0.01, respectively). The peak velocity of the myocardial systolic wave (Sm) was significantly decreased in the lateral wall (p = 0.02) and approached statistical significance in the posterior wall (p = 0.07). These results suggest concomitant changes in myocardial systolic and diastolic function with moderate doses of anthracyclines. Therefore, pulsed Doppler tissue examination enables earlier detection of left ventricular cardiotoxicity with anthracyclines than classical echocardiographic parameters.
- Published
- 2002
48. [Prediction of improvement of left ventricular systolic function by dobutamine echocardiography after recent myocardial infarction]
- Author
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O, Lozé, S, Tassan-Mangina, P, Nazeyrollas, C, Brasselet, P, Laury, L, Bonfils, B, Jamet, A, Deschildre, D, Metz, and J, Elaerts
- Subjects
Adult ,Male ,Cardiotonic Agents ,Systole ,Myocardial Infarction ,Myocardial Ischemia ,Middle Aged ,Prognosis ,Ventricular Function, Left ,Echocardiography ,Dobutamine ,Humans ,Female ,Aged - Abstract
Left ventricular ejection fraction is a major prognostic factor of ischaemic heart disease. In the early phase of myocardial infarction, part of the myocardium may be stunned and responsible for marked segmental wall dysfunction which is potentially reversible. The authors studied the potential of low dose dobutamine echocardiography to predict secondary improvement of left ventricular systolic function in 21 patients with recent inaugural myocardial infarction without primary angioplasty. All patients were treated and the investigation was carried out up to 20 micrograms/Kg/min of dobutamine without unwanted side-effects or myocardial ischaemia. The detection of viability by this method was associated with improved wall motion of the affected segments in 74% of cases, most of which had benefited from myocardial revascularisation at control echocardiography performed 8 weeks later. If 4 or more segments were estimated to be viable initially, the left ventricular ejection fraction improved to a value comparable to that obtained at a dosage of 20 micrograms/Kg/min of dobutamine. On the other hand, there was no secondary improvement in 76% of segments estimated to be non-viable whether or not they had been revascularised. The sensitivity, specificity, positive and negative predictive values of low dose dobutamine echocardiography for prediction of myocardial recovery after recent infarction were respectively 71, 79, 74 and 76%. The results of this investigation show prognostic value and could be an aid to the decision concerning revascularisation of patients not having undergone primary angioplasty.
- Published
- 2001
49. [Comparative evaluation of hydrophilic and standard guide wires for retrograde catheterization of severe aortic stenosis]
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B, Jamet, D, Metz, C, Brasselet, J P, Chabert, C, Blaise, S, Tassan-Mangina, A, Deschildre, P, Nazeyrollas, and J, Elaerts
- Subjects
Male ,Cardiac Catheterization ,Treatment Outcome ,Humans ,Female ,Aortic Valve Stenosis ,Equipment Design ,Middle Aged ,Aged - Abstract
The feasibility and safety of using hydrophilic guide wires were compared with those of standard guide wires for retrograde catheterization of aortic stenosis in a prospective randomised study. The performances of the guide wires were assessed by the time taken to catheterize the aortic valve (minutes) and the duration of radioscopy (minutes: grays). The success of the procedure was defined as presence of the guide in the left ventricle in less than 8 minutes. The two patient groups were comparable with respect to the severity of the aortic stenosis. Two failures of catheterisation were observed in the "standard guide wire" group compared with three failures with the hydrophilic guide wire. The mean catheterisation time of the "standard" group was 2.56 minutes compared with 3.12 minutes with the hydrophilic guide wire (p = 0.35 NS). This result was correlated with the duration of radioscopy and number of groups (respectively p = 0.18 NS and p = 0.5 NS). One case of tamponade and a transient ischaemic cerebral attack were observed in the "standard" group. This study does not show the hydrophilic guide wire to be superior to the standard guide wire for catheterisation of aortic stenosis. However, the hydrophilic guide wires were perfectly innocuous for this procedure.
- Published
- 2001
50. Cardiopathie hypokinétique dilatée curable chez l’adulte : penser à la carnitine !
- Author
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R Garnotel, P. Nazeyrollas, Amélie Servettaz, F. Lesaffre, and Roland Jaussaud
- Subjects
Gastroenterology ,Internal Medicine - Published
- 2010
- Full Text
- View/download PDF
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