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Chitosan derivative was successively synthesized by initial preparation of acyl thiourea reagent using ammonium thiocyanate and making it to react with at primary amino groups of chitosan and then reduced to yield Thiolated Chitosan. Due to the formation of disulphide bonds with mFucus glycoproteins, mucoadhesiveness is augmented. The thiol groups were then quantified using Ellman’s reagent. The derivatives inherit good swelling property in neutral and alkaline media. The different derivatives containing thiol groups were formulated into tablets using reference drug for evaluation. The Thiolated Chitosan display in situ gelling features due to the pH-dependent (alkaline pH) formation of inter-molecular disulphide bonds which makes the application of Thiolated Chitosan on intestinal mucosa and can guarantee prolonged controlled release of embedded therapeutic ingredients. Keywords: Thiolated Chitosan, Acyl isothiocyanate, Isopropanol, Mucoadhesion, Matrix tablet

Tagetes erecta plant Synonym Aztec Marigold. The Tagetes erecta commonly known as Genduphul. the leaves of plant collected and authenticated and powdered and extracted with methanol as solvent by soxhlet extraction method. The phytochemical evaluation and phytochemical screening of extract was done, the plant showed presence of flavanoids, tannin, alkaloids, carbohydrate, terpenoids. These constituent was separated from each other by thin layer chromatography, Isolated by column chromatography these spots was send for spectral analysis .the antiulcer activity was performed, by ethanol induced method.

Glycolamide esters (compounds 1-17) of 2-(3-trifluoromethyl-phenylamino)nicotinic acid (niflumic acid, CAS 4394-00-7) have been synthesized and evaluated as possible prodrugs. In-vitro hydrolysis studies were conducted at selected pH values (1.2, 3.5, 4.8, 7.4 and 7.8) and in human plasma at 37 +/- 0.5 degree C using HPLC with UV detection. The aqueous (pH 7.4 and 7.8) and enzymatic rates of hydrolysis were substantially affected by the nature of promoieties in this series. The compounds showed good chemical stability in the buffers of low pH values (1.2, 3.5 and 4.8) and appreciable hydrolysis under alkaline conditions and in human plasma. They exhibited long hydrolytic half-lives of 7-46 h in aqueous buffer solutions (pH 7.4 and 7.8) and 14-21 min in human plasma, respectively. It was observed that N,N-disubstituted and cyclic glycolamide derivatives showed 2 fold more hydrolysis in the alkaline pH than monosubstituted derivatives, whereas the piperidino and thiomorpholino derivatives did not undergo chemical hydrolysis. The compounds contain two possible sites for hydrolysis with an increased hydrolytic susceptibility at the terminal aliphatic carbonyl site in aqueous buffers and human plasma solutions. They were found to be cleaved at two hydrolytic carbonyls, namely the nicotinyl (2-5 % in enzymatic hydrolysis) and the aliphatic site (7-55 % and 70-85 % in buffer and plasma hydrolysis, respectively) as revealed by HPLC analysis. The glycolamide ester prodrugs of niflumic acid underwent chemical and enzymatic hydrolysis to release mainly the metabolite 2-(3-trifluoromethyl-phenylamino) nicotinic acid carboxymethyl ester (III) and not the parent drug 2-(3-trifluoromethyl-phenylamino)nicotinic acid. The structure of the metabolite was confirmed by liquid chromatography-mass spectroscopy (LCMS).

In an effort to develop potent anticonvulsant agents, we have synthesized some novel schiff’s bases of 3-{[2-({(E)-[substituted) phenyl] methylidene} amino) ethyl] amino} quinoxalin-2(1H)-one and evaluated for in vivo anticonvulsant activity. All the compounds were characterized by IR, 1 H NMR data. This activity was carried out on pentylenetetrazole-induced seizure model. Compounds (IIIb) and (IIIc) Showed maximum time for straub tail and clonic convulsions. That means they possess good activity compared with standard. Animals treated with compounds (IIIb) and (IIIe) were recovered from this activity.

Aloe is the dried juice of the leaves of Aloe barbadensis Miller, known as Curacao aloes; or of Aloe perryi Baker, known as Socotrine aloes; or of Aloe ferox Miller and hybrids of this species with Aloe Africana Miller and Aloe spicata Baker, known as Cape aloes, belonging to family Liliaceae.1. The aim of the present review article is to study different methods to overcome the stability problem of aloe gel. This review article deals with methods like selection and optimization of gelling agent, use of high hydrostatic pressure for processing and formulation of polyelectrolyte complex beads to enhance stability of aloe gel. Carboxy methylcellulose sodium, Carbomer 934, HPMC and different concentration of viscosity enhancer can be used to increase the stability of aloe gel. High hydrostatic pressure (HHP) is an innovative emerging technology to increase the stability of aloe vera gel. High Hydrostatic Pressure involves the application of pressure on the product within a range of 50 to 1000 MPa. It has been reported that pressure up to 350 MPa can be applied to plant systems without any major effect on texture and structure. Another method to overcome the stability problem of aloe gel is formulation of polyelectrolyte-complex beads using chitosan-sodium alginate and suspending them into calamine lotion. The gels obtained by using either of above methods were evaluated for pH, colour, viscosity and stability.