Author: "P. Guerci" - Searchworks@Jio Institute Digital Library Search Results

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936 results on '"P. Guerci"'

1. Topological superconductivity from repulsive interactions in twisted WSe$_2$

Author: Guerci, Daniele, Kaplan, Daniel, Ingham, Julian, Pixley, J. H., and Millis, Andrew J.
Subjects: Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract: The recent observation of superconductivity in twisted bilayer WSe$_2$ raises intriguing questions concerning the origin and the properties of superconducting states realized in bands with non-trivial topological properties and repulsive electron-electron interactions. Using a continuum band structure model, we analyze a mechanism for Coulomb interaction-driven superconductivity in twisted bilayers of WSe$_2$. We discuss the symmetries and the phenomenological properties of the resulting superconducting phases and their evolution with interlayer potential difference, tunable via an out of plane electric field. The pairing strength is a non-monotonic function of interlayer potential, being larger at intermediate values due to mixing of singlet and triplet pairing. In contrast, at larger interlayer potential, the pairing tendency is suppressed due to enhanced Coulomb repulsion. The superconducting state is chiral in a large regime of parameters and undergoes a transition to a nodal nematic superconductor at a critical potential difference. The chiral state, characterized by an intervalley-symmetric superposition of triplet and singlet pairs, is classified as a topological superconductor within the Altland-Zirnbauer class C. At zero interlayer potential difference, the superconducting state is instead of class D, which hosts Majorana zero modes, making it a promising candidate for applications in quantum computation., Comment: 9+11 pages, 4+9 figures
Published: 2024

2. Layer skyrmions for ideal Chern bands and twisted bilayer graphene

Author: Guerci, Daniele, Wang, Jie, and Mora, Christophe
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics
Abstract: Ideal $C=1$ Chern bands exhibit a Landau level correspondence: they factorize as a lowest Landau levels and a spinor wavefunction that spans the layer index. We demonstrate that, in single Dirac moir\'e models, the spinor develops generally a Skyrme texture in real space with an associated Berry phase which compensates exactly the magnetic phase of the Landau level. For ideal bands with higher Chern numbers $C>1$, we find that $C$ color Landau levels are carried by $C$ spinors with Skyrme textures. We identify a SU(C) gauge symmetry in the color space of spinors and an emergent non-Abelian connection in real space intimately linked to the Pontryagin winding index of the layer skyrmions. They result in a total real-space Chern number of $-1$, screening the magnetic phase, irrespective of $C$ and of the number of layers. The topologically robust Skyrme texture remains remarkably intact in twisted bilayer graphene, even far from the chiral limit, and for realistic values of corrugation, making it an experimentally testable feature. We verify our predictions at the first magic angle of twisted bilayer, trilayer, and monolayer-bilayer graphene., Comment: 8+13 pages, 6 figures
Published: 2024

3. Topological Kondo semimetal and insulator in AB-stacked heterobilayer transition metal dichalcogenides

Author: Guerci, Daniele, Lucht, Kevin P., Crépel, Valentin, Cano, Jennifer, Pixley, J. H., and Millis, Andrew J.
Subjects: Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract: Recent experiments reported the realization of a heavy Fermi liquid in AB-stacked MoTe$_2$/WSe$_2$ heterobilayers. In this paper we show that the AB-stacked heterobilayer configuration is particularly suited to realize topological Kondo semimetal and topological Kondo insulator ground states at a doping of two holes per moir\'e unit cell. The small lattice mismatch between the MoTe$_2$ and WSe$_2$ monolayers and the different bandwidths of their highest lying moir\'e valence bands means that, in the experimentally relevant range of hole dopings, the MoTe$_2$ layer is effectively a Mott insulator with only low-lying magnetic excitations Kondo-coupled to more itinerant electrons in the WSe$_2$. The crucial consequence of the AB-stacking configuration is that the interlayer tunnelling connects orbitals of opposite parity in the two layers, leading to a chiral Kondo coupling. We show that the chiral Kondo coupling favors a topological Kondo semimetal at filling $\nu=1+1$, with a non-quantized spin Hall conductance arising from edge modes, whose spectrum and overlap with bulk states we determine. We further show that a spatially random strain field that locally breaks the rotation symmetry can convert the Kondo semimetal to a narrow gap topological Kondo insulator featuring a quantized spin Hall conductance., Comment: 12 pages, 11 figures
Published: 2024

4. Electrical Transport in the Hatsugai-Kohmoto Model

Author: Guerci, Daniele, Sangiovanni, Giorgio, Millis, Andrew J., and Fabrizio, Michele
Subjects: Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract: We show that in models with the Hatsugai-Kohmoto type of interaction that is local in momentum space thus infinite-range in real space, Kubo formulas neither reproduce the correct thermodynamic susceptibilities, nor yield sensible transport coefficients. Using Kohn's trick to differentiate between metals and insulators by threading a flux in a torus geometry, we uncover the striking property that Hatsugai-Kohmoto models with an interaction-induced gap in the spectrum sustain a current that grows as the linear size at any non-zero flux and which can be either diamagnetic or paramagnetic., Comment: 7 pages, 1 figure
Published: 2024

5. Helical trilayer graphene in magnetic field: Chern mosaic and higher Chern number ideal flat bands

Author: Datta, Anushree, Guerci, Daniele, Goerbig, Mark O., and Mora, Christophe
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Strongly Correlated Electrons
Abstract: Helical trilayer graphene (hTG) exhibits a supermoir\'e pattern with large domains centered around stacking points ABA and BAB, where two well-separated low-energy bands appear with different total Chern numbers at each valley, forming a Chern mosaic pattern. In the chiral limit, the low-energy bands become exactly flat at zero energy for magic-angle twists. Here we investigate these zero-energy flat bands and their topological properties in the presence of a perpendicular magnetic field. We show that hTG retains the precise flatness of the zero-energy bands, even at finite magnetic fields. We find topological phase transitions at fields corresponding to unit and half magnetic flux leading to an emergence of higher Chern number flat bands. Consequently the Chern mosaic gets modified for finite magnetic fields. We further find the analytical forms of zero-energy wave functions and identify a set of hidden wave functions, which gives crucial insights into both the topological transitions and enhancement of Chern numbers across them. We also find topological transitions away from the chiral limit with finite corrugations and at different magic angles., Comment: 16 pages, 7 figures
Published: 2024
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6. Sublattice structure and topology in spontaneously crystallized electronic states

Author: Zeng, Yongxin, Guerci, Daniele, Crépel, Valentin, Millis, Andrew J., and Cano, Jennifer
Subjects: Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract: The prediction and realization of the quantum anomalous Hall effect are often intimately connected to honeycomb lattices in which the sublattice degree of freedom plays a central role in the nontrivial topology. Two-dimensional Wigner crystals, on the other hand, form triangular lattices without sublattice degrees of freedom, resulting in a topologically trivial state. In this Letter, we discuss the possibility of spontaneously formed honeycomb-lattice crystals that exhibit the quantum anomalous Hall effect. Starting from a single-band system with nontrivial quantum geometry, we derive the mean-field energy functional of a class of crystal states and express it as a model of sublattice pseudospins in momentum space. We find that nontrivial quantum geometry leads to extra terms in the pseudospin model that break an effective `time-reversal symmetry' and favor a topologically nontrivial pseudospin texture. When the effects of these extra terms dominate over the ferromagnetic exchange coupling between pseudospins, the anomalous Hall crystal state becomes energetically favorable over the trivial Wigner crystal state.
Published: 2024
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7. Absence of quantization in the circular photogalvanic effect in disordered chiral Weyl semimetals

Author: Wu, Ang-Kun, Guerci, Daniele, Fu, Yixing, Wilson, Justin H., and Pixley, J. H.
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Disordered Systems and Neural Networks
Abstract: The circularly polarized photogalvanic effect (CPGE) is studied in chiral Weyl semimetals with short-ranged quenched disorder. Without disorder, the topological properties of chiral Weyl semimetals lead to the quantization of the CPGE, which is a second-order optical response. Using a combination of diagrammatic perturbation theory in the continuum and exact numerical calculations via the kernel polynomial method on a lattice model we show that disorder perturbatively destabilizes the quantization of the CPGE., Comment: 16 pages, 11 figures
Published: 2023
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8. Edge zeros and boundary spinons in topological Mott insulators

Author: Wagner, Niklas, Guerci, Daniele, Millis, Andrew J., and Sangiovanni, Giorgio
Subjects: Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract: We introduce a real-space slave rotor theory of the physics of topological Mott insulators, using the Kane-Mele-Hubbard model as an example, and use it to show that a topological gap in the Green function zeros corresponds to a gap in the bulk spinon spectrum and that a zero edge mode corresponds to a spinon edge mode. We then consider an interface between a topological Mott insulator and a conventional topological insulator showing how the spinon edge mode of the topological Mott insulator combines with the spin part of the conventional electron topological edge state leaving a non-Fermi liquid edge mode described by a gapless propagating holon and gapped spinon state. Our work demonstrates the physical meaning of Green function zeros and shows that interfaces between conventional and Mott topological insulators are a rich source of new physics., Comment: 7+5 pages, 4+3 figures
Published: 2023
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9. Heterogeneity of glycaemic phenotypes in type 1 diabetes

Author: Fagherazzi, Guy, Aguayo, Gloria A., Zhang, Lu, Hanaire, Hélène, Picard, Sylvie, Sablone, Laura, Vergès, Bruno, Hamamouche, Naïma, Detournay, Bruno, Joubert, Michael, Delemer, Brigitte, Guilhem, Isabelle, Vambergue, Anne, Gourdy, Pierre, Hadjadj, Samy, Velayoudom, Fritz-Line, Guerci, Bruno, Larger, Etienne, Jeandidier, Nathalie, Gautier, Jean-François, Renard, Eric, Potier, Louis, Benhamou, Pierre-Yves, Sola, Agnès, Bordier, Lyse, Bismuth, Elise, Prévost, Gaëtan, Kessler, Laurence, Cosson, Emmanuel, and Riveline, Jean-Pierre
Published: 2024
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10. Imaging Self-aligned Moir\'e Crystals and Quasicrystals in Magic-angle Bilayer Graphene on hBN Heterostructures

Author: Lai, Xinyuan, Guerci, Daniele, Li, Guohong, Watanabe, Kenji, Taniguchi, Takashi, Wilson, Justin, Pixley, Jedediah H., and Andrei, Eva Y.
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics
Abstract: Using scanning-tunneling-microscopy and theoretical modeling on heterostructures of twisted bilayer graphene and hexagonal Boron-Nitride, we show that the emergent super-moire structures display a rich landscape of moire-crystals and quasicrystals. We reveal a phase-diagram comprised of commensurate moire-crystals embedded in swaths of moire quasicrystals. The 1:1 commensurate crystal, expected to be a Chern insulator, should only exist at one point on the phase-diagram, implying that it ought to be practically undetectable. Surprisingly we find that the commensurate crystals exist over a much wider than predicted range, providing evidence of an unexpected self-alignment mechanism that is explained using an elastic-network model. The remainder of the phase-diagram, where we observe tunable quasicrystals, affords a new platform for exploring the unique electronic-properties of these rarely found in nature structures., Comment: 37 pages, 18 figures
Published: 2023

11. ESICM LIVES 2016: part one

Author: L. Bos, L. Schouten, L. van Vught, M. Wiewel, D. Ong, O. Cremer, A. Artigas, I. Martin-Loeches, A. Hoogendijk, T. van der Poll, J. Horn, N. Juffermans, M. Schultz, N. de Prost, T. Pham, G. Carteaux, A. Mekontso Dessap, C. Brun-Buisson, E. Fan, G. Bellani, J. Laffey, A. Mercat, L. Brochard, B. Maitre, LUNG SAFE investigators and the ESICM study group, P. A. Howells, D. R. Thickett, C. Knox, D. P. Park, F. Gao, O. Tucker, T. Whitehouse, D. F. McAuley, G. D. Perkins, LUNG SAFE Investigators and the ESICM Trials Group, L. Pisani, J. P. Roozeman, F. D. Simonis, A. Giangregorio, L. R. Schouten, S. M. Van der Hoeven, A. Serpa Neto, E. Festic, A. M. Dondorp, S. Grasso, L. D. Bos, M. J. Schultz, M. Koster-Brouwer, D. Verboom, B. Scicluna, K. van de Groep, J. Frencken, M. Bonten, J. I. Ko, K. S. Kim, G. J. Suh, W. Y. Kwon, K. Kim, J. H. Shin, O. T. Ranzani, E. Prina, R. Menendez, A. Ceccato, R. Mendez, C. Cilloniz, A. Gabarrus, M. Ferrer, A. Torres, A. Urbano, L. A. Zhang, D. Swigon, F. Pike, R. S. Parker, G. Clermont, C. Scheer, S. O. Kuhn, A. Modler, M. Vollmer, C. Fuchs, K. Hahnenkamp, S. Rehberg, M. Gründling, A. Taggu, N. Darang, N. Öveges, I. László, K. Tánczos, M. Németh, G. Lebák, B. Tudor, D. Érces, J. Kaszaki, W. Huber, D. Trásy, Z. Molnár, G. Ferrara, V. S. Kanoore Edul, H. S. Canales, E. Martins, C. Canullán, G. Murias, M. O. Pozo, J. F. Caminos Eguillor, M. G. Buscetti, C. Ince, A. Dubin, H. D. Aya, A. Rhodes, N. Fletcher, R. M. Grounds, M. Cecconi, M. Jacquet-Lagrèze, M. Riche, R. Schweizer, P. Portran, W. Fornier, M. Lilot, J. Neidecker, J. L. Fellahi, A. Escoresca-Ortega, A. Gutiérrez-Pizarraya, L. Charris-Castro, Y. Corcia-Palomo, E. Fernandez-Delgado, J. Garnacho-Montero, C. Roger, L. Muller, L. Elotmani, J. Lipman, J. Y. Lefrant, J. A. Roberts, R. Muñoz-Bermúdez, M. Samper, C. Climent, F. Vasco, V. Sara, S. Luque, N. Campillo, S. Grau Cerrato, J. R. Masclans, F. Alvarez-Lerma, S. Carvalho Brugger, G. Jimenez Jimenez, M. Miralbés Torner, J. Trujillano Cabello, B. Balsera Garrido, X. Nuvials Casals, F. Barcenilla Gaite, M. Vallverdú Vidal, M. Palomar Martínez, V. Gusarov, D. Shilkin, M. Dementienko, E. Nesterova, N. Lashenkova, A. Kuzovlev, M. Zamyatin, A. Demoule, S. Carreira, S. Lavault, O. Palancca, E. Morawiec, J. Mayaux, I. Arnulf, T. Similowski, B. S. Rasmussen, R. G. Maltesen, M. Hanifa, S. Pedersen, S. R. Kristensen, R. Wimmer, M. Panigada, G. Li Bassi, T. Kolobow, A. Zanella, M. Cressoni, L. Berra, V. Parrini, H. Kandil, G. Salati, S. Livigni, A. Amatu, A. Andreotti, F. Tagliaferri, G. Moise, G. Mercurio, A. Costa, A. Vezzani, S. Lindau, J. Babel, M. Cavana, D. Consonni, A. Pesenti, L. Gattinoni, for the GRAVITY-VAP TRIAL NETWORK, P. Mansouri, F. Zand, L. Zahed, F. Dehghanrad, M. Bahrani, M. Ghorbani, B. Cambiaghi, O. Moerer, T. Mauri, N. Kunze-Szikszay, C. Ritter, M. Quintel, L. M. Vilander, M. A. Kaunisto, S. T. Vaara, V. Pettilä, FINNAKI Study Group, J. L. G. Haitsma Mulier, S. Rozemeijer, A. M. E. Spoelstra-de Man, P. E. Elbers, P. R. Tuinman, M. C. de Waard, H. M. Oudemans-van Straaten, A. M. A. Liberatore, R. B. Souza, A. M. C. R. P. F. Martins, J. C. F. Vieira, I. H. J. Koh, M. Galindo Martínez, R. Jiménez Sánchez, L. Martínez Gascón, M. D. Rodríguez Mulero, A. Ortín Freire, A. Ojados Muñoz, S. Rebollo Acebes, Á. Fernández Martínez, S. Moreno Aliaga, L. Herrera Para, J. Murcia Payá, F. Rodríguez Mulero, P. Guerci, Y. Ince, P. Heeman, B. Ergin, Z. Uz, M. Massey, R. Papatella, E. Bulent, F. Toraman, E. R. Longbottom, H. D. Torrance, H. C. Owen, C. J. Hinds, R. M. Pearse, M. J. O’Dywer, Z. Trogrlic, M. van der Jagt, H. Lingsma, H. H. Ponssen, J. F. Schoonderbeek, F. Schreiner, S. J. Verbrugge, S. Duran, T. van Achterberg, J. Bakker, D. A. M. P. J. Gommers, E. Ista, A. Krajčová, P. Waldauf, F. Duška, A. Shah, N. Roy, S. McKechnie, C. Doree, S. Fisher, S. J. Stanworth, J. F. Jensen, D. Overgaard, M. H. Bestle, D. F. Christensen, I. Egerod, The RAPIT Group, A. Pivkina, I. Zhivotneva, N. Pasko, A. Alklit, R. L. Hansen, H. Knudsen, L. B. Grode, The RAPIT group, M. Hravnak, L. Chen, A. Dubrawski, M. R. Pinsky, S. M. Parry, L. D. Knight, B. C. Connolly, C. E. Baldwin, Z. A. Puthucheary, L. Denehy, N. Hart, P. E. Morris, J. Mortimore, C. L. Granger, H. I. Jensen, R. Piers, B. Van den Bulcke, J. Malmgren, V. Metaxa, A. K. Reyners, M. Darmon, K. Rusinova, D. Talmor, A. P. Meert, L. Cancelliere, L. Zubek, P. Maia, A. Michalsen, J. Decruyenaere, E. Kompanje, S. Vanheule, E. Azoulay, S. Vansteelandt, D. Benoit, C. Ryan, D. Dawson, J. Ball, K. Noone, B. Aisling, S. Prudden, A. Ntantana, D. Matamis, S. Savvidou, M. Giannakou, M. Gouva, G. Nakos, V. Koulouras, J. Aron, G. Lumley, D. Milliken, K. Dhadwal, B. A. McGrath, S. J. Lynch, B. Bovento, G. Sharpe, E. Grainger, S. Pieri-Davies, S. Wallace, B. McGrath, M. Jung, J. Cho, H. Park, G. Suh, O. Kousha, J. Paddle, L. Gamrin Gripenberg, M. Sundström Rehal, J. Wernerman, O. Rooyackers, H. J. de Grooth, W. P. Choo, A. M. Spoelstra-de Man, E. L. Swart, L. Talan, G. Güven, N. D. Altıntas, M. Padar, G. Uusvel, L. Starkopf, J. Starkopf, A. Reintam Blaser, M. S. Kalaiselvan, A. S. Arunkumar, M. K. Renuka, R. L. Shivkumar, M. Volbeda, D. ten Kate, M. Hoekstra, J. M. van der Maaten, M. W. Nijsten, A. Komaromi, Å. Norberg, M. Smedberg, M. Mori, L. Pettersson, M. Theodorakopoulou, T. Christodoulopoulou, A. Diamantakis, F. Frantzeskaki, M. Kontogiorgi, E. Chrysanthopoulou, M. Lygnos, C. Diakaki, A. Armaganidis, K. Gundogan, E. Dogan, R. Coskun, S. Muhtaroglu, M. Sungur, T. Ziegler, M. Guven, A. Kleyman, W. Khaliq, D. Andreas, M. Singer, R. Meierhans, R. Schuepbach, I. De Brito-Ashurst, G. Sabetian, R. Nikandish, F. Hagar, M. Masjedi, B. Maghsudi, A. Vazin, E. Asadpour, K. C. Kao, L. C. Chiu, C. Y. Hung, C. H. Chang, S. H. Li, H. C. Hu, S. El Maraghi, M. Ali, D. Rageb, M. Helmy, J. Marin-Corral, C. Vilà, A. Vàzquez, I. Martín-Loeches, E. Díaz, J. C. Yébenes, A. Rodriguez, F. Álvarez-Lerma, H1N1 SEMICYUC/GETGAG Working Group, N. Varga, A. Cortina-Gutiérrez, L. Dono, M. Martínez-Martínez, C. Maldonado, E. Papiol, M. Pérez-Carrasco, R. Ferrer, K. Nweze, B. Morton, I. Welters, M. Houard, B. Voisin, G. Ledoux, S. Six, E. Jaillette, S. Nseir, S. Romdhani, R. Bouneb, D. Loghmari, N. Ben Aicha, J. Ayachi, K. Meddeb, I. Chouchène, A. Khedher, M. Boussarsar, K. S. Chan, W. L. Yu, J. Nolla, L. Vidaur, J. Bonastre, B. Suberbiola, J. E. Guerrero, H1N1 SEMICYUC/GETGAG working group, N. Ramon Coll, G. Jiménez Jiménez, J. Codina Calero, M. García, M. C. de la Torre, E. Vendrell, E. Palomera, E. Güell, M. Serra-Prat, J. F. Bermejo-Martín, J. Almirall, E. Tomas, A. Escoval, F. Froe, M. H. Vitoria Pereira, N. Velez, E. Viegas, E. Filipe, C. Groves, M. Reay, A. Ballin, F. Facchin, G. Sartori, F. Zarantonello, E. Campello, C. M. Radu, S. Rossi, C. Ori, P. Simioni, N. Umei, I. Shingo, A. C. Santos, C. Candeias, I. Moniz, R. Marçal, Z. Costa e Silva, J. M. Ribeiro, J. F. Georger, J. P. Ponthus, M. Tchir, V. Amilien, M. Ayoub, E. Barsam, G. Martucci, G. Panarello, F. Tuzzolino, G. Capitanio, V. Ferrazza, T. Carollo, L. Giovanni, A. Arcadipane, M. López Sánchez, M. A. González-Gay, F. J. Llorca Díaz, M. I. Rubio López, E. Zogheib, L. Villeret, J. Nader, M. Bernasinski, P. Besserve, T. Caus, H. Dupont, P. Morimont, S. Habran, R. Hubert, T. Desaive, F. Blaffart, N. Janssen, J. Guiot, A. Pironet, P. Dauby, B. Lambermont, T. Pettenuzzo, G. Citton, C. Kirakli, O. Ediboglu, S. Ataman, M. Yarici, F. Tuksavul, S. Keating, A. Gibson, M. Gilles, M. Dunn, G. Price, N. Young, P. Remeta, P. Bishop, M. D. Fernández Zamora, J. Muñoz-Bono, E. Curiel-Balsera, E. Aguilar-Alonso, R. Hinojosa, A. Gordillo-Brenes, J. A. Arboleda-Sánchez, ARIAM-CARDIAC SURGERY PROJECT AUTHORS, I. Skorniakov, D. Vikulova, C. Whiteley, O. Shaikh, A. Jones, M. Ostermann, L. Forni, M. Scott, J. Sahatjian, W. Linde-Zwirble, D. Hansell, P. Laoveeravat, N. Srisawat, M. Kongwibulwut, S. Peerapornrattana, N. Suwachittanont, T. O. Wirotwan, P. Chatkaew, P. Saeyub, K. Latthaprecha, K. Tiranathanagul, S. Eiam-ong, J. A. Kellum, R. E. Berthelsen, A. Perner, A. E. K. Jensen, J. U. Jensen, D. J. Gebhard, J. Price, C. E. Kennedy, A. Akcan-Arikan, Y. R. Kang, M. N. Nakamae, K. Hamed, M. M. Khaled, R. Aly Soliman, M. Sherif Mokhtar, G. Seller-Pérez, D. Arias-Verdú, E. Llopar-Valdor, I. De-Diós-Chacón, G. Quesada-García, M. E. Herrera-Gutierrez, R. Hafes, G. Carroll, P. Doherty, C. Wright, I. G. Guerra Vera, M. Ralston, M. L. Gemmell, A. MacKay, E. Black, R. I. Docking, R. Appleton, M. R. Ralston, L. Gemmell, A. Mackay, J. G. Röttgering, P. W. G. Elbers, N. Mejeni, J. Nsiala, A. Kilembe, P. Akilimali, G. Thomas, A. E. Andersson, A. M. Fagerdahl, V. Knudsen, P-INFECT, A. Ben Cheikh, Y. Hamdaoui, A. Guiga, N. Fraj, N. Sma, I. Chouchene, N. Bouafia, A. Amirian, B. Ziaian, C. Fleischmann, D. O. Thomas-Rueddel, A. Schettler, D. Schwarzkopf, A. Stacke, K. Reinhart, A. Martins, P. Sousa, G. Snell, R. Matsa, T. T. S. Paary, A. M. Cavalheiro, L. L. Rocha, C. S. Vallone, A. Tonilo, M. D. S. Lobato, D. T. Malheiro, G. Sussumo, N. M. Lucino, V. D. Rosenthal, A. Sanaei Dashti, A. Yousefipour, J. R. Goodall, M. Williamson, E. Tant, N. Thomas, C. Balci, C. Gonen, E. Haftacı, H. Gurarda, E. Karaca, B. Paldusová, I. Zýková, D. Šímová, S. Houston, L. D’Antona, J. Lloyd, V. Garnelo-Rey, M. Sosic, V. Sotosek-Tokmazic, J. Kuharic, I. Antoncic, S. Dunatov, A. Sustic, C. T. Chong, M. Sim, T. Lyovarin, F. M. Acosta Díaz, S. Narbona Galdó, M. Muñoz Garach, O. Moreno Romero, A. M. Pérez Bailón, A. Carranza Pinel, M. Colmenero, A. Gritsan, A. Gazenkampf, E. Korchagin, N. Dovbish, R. M. Lee, M. P. P. Lim, B. C. L. Lim, J. J. See, R. Assis, F. Filipe, N. Lopes, L. Pessoa, T. Pereira, N. Catorze, M. S. Aydogan, C. Aldasoro, P. Marchio, A. Jorda, M. D. Mauricio, S. Guerra-Ojeda, M. Gimeno-Raga, M. Colque-Cano, A. Bertomeu-Artecero, M. Aldasoro, S. L. Valles, D. Tonon, T. Triglia, J. C. Martin, M. C. Alessi, N. Bruder, P. Garrigue, L. Velly, S. Spina, V. Scaravilli, C. Marzorati, E. Colombo, D. Savo, A. Vargiolu, G. Cavenaghi, G. Citerio, A. H. V. Andrade, P. Bulgarelli, J. A. P. Araujo, V. Gonzalez, V. A. Souza, C. Massant, C. A. C. Abreu Filho, R. A. Morbeck, L. E. Burgo, R. van Groenendael, L. T. van Eijk, G. P. Leijte, B. Koeneman, M. Kox, P. Pickkers, A. García-de la Torre, M. de la Torre-Prados, A. Fernández-Porcel, C. Rueda-Molina, P. Nuevo-Ortega, T. Tsvetanova-Spasova, E. Cámara-Sola, A. García-Alcántara, L. Salido-Díaz, X. Liao, T. Feng, J. Zhang, X. Cao, Q. Wu, Z. Xie, H. Li, Y. Kang, M. S. Winkler, A. Nierhaus, E. Mudersbach, A. Bauer, L. Robbe, C. Zahrte, E. Schwedhelm, S. Kluge, C. Zöllner, E. Mitsi, S. H. Pennington, J. Reine, A. D. Wright, R. Parker, I. D. Welters, J. D. Blakey, G. Rajam, E. W. Ades, D. M. Ferreira, D. Wang, A. Kadioglu, S. B. Gordon, R. Koch, J. Rahamat-Langedoen, J. Schloesser, M. de Jonge, J. Bringue, R. Guillamat-Prats, E. Torrents, M. L. Martinez, M. Camprubí-Rimblas, L. Blanch, S. Y. Park, Y. B. Park, D. K. Song, S. Shrestha, S. H. Park, Y. Koh, M. J. Park, C. W. Hong, O. Lesur, D. Coquerel, X. Sainsily, J. Cote, T. Söllradl, A. Murza, L. Dumont, R. Dumaine, M. Grandbois, P. Sarret, E. Marsault, D. Salvail, M. Auger-Messier, F. Chagnon, Apelin Group, M. P. Lauretta, E. Greco, A. Dyson, S. Preau, M. Ambler, A. Sigurta, S. Saeed, L. Topcu Sarıca, N. Zibandeh, D. Genc, F. Gul, T. Akkoc, E. Kombak, L. Cinel, I. Cinel, S. J. Pollen, N. Arulkumaran, G. Warnes, D. J. Pennington, K. Brohi, M. J. O’Dwyer, H. Y. Kim, S. Na, J. Kim, Y. F. Chang, A. Chao, P. Y. Shih, C. T. Lee, Y. C. Yeh, L. W. Chen, M. Adriaanse, W. Rietdijk, S. Funcke, S. Sauerlaender, B. Saugel, H. Pinnschmidt, D. A. Reuter, R. Nitzschke, S. Perbet, C. Biboulet, A. Lenoire, D. Bourdeaux, B. Pereira, B. Plaud, J. E. Bazin, V. Sautou, A. Mebazaa, J. M. Constantin, M. Legrand, Y. Boyko, P. Jennum, M. Nikolic, H. Oerding, R. Holst, P. Toft, H. K. Nedergaard, T. Haberlandt, S. Park, S. Kim, Y. J. Cho, Y. J. Lim, A. Chan, S. Tang, S. L. Nunes, S. Forsberg, H. Blomqvist, L. Berggren, M. Sörberg, T. Sarapohja, C. J. Wickerts, J. G. M. Hofhuis, L. Rose, B. Blackwood, E. Akerman, J. Mcgaughey, M. Fossum, H. Foss, E. Georgiou, H. J. Graff, M. Kalafati, R. Sperlinga, A. Schafer, A. G. Wojnicka, P. E. Spronk, F. Khalili, R. Afshari, H. Haddad Khodaei, S. Javadpour, P. Petramfar, S. Nasimi, H. Tabei, A. Gunther, J. O. Hansen, P. Sackey, H. Storm, J. Bernhardsson, Ø. Sundin, A. Bjärtå, A. Bienert, P. Smuszkiewicz, P. Wiczling, K. Przybylowski, A. Borsuk, I. Trojanowska, J. Matysiak, Z. Kokot, M. Paterska, E. Grzeskowiak, A. Messina, E. Bonicolini, D. Colombo, G. Moro, S. Romagnoli, A. R. De Gaudio, F. Della Corte, S. M. Romano, J. A. Silversides, E. Major, E. E. Mann, A. J. Ferguson, D. F. Mcauley, J. C. Marshall, J. A. Diaz-Rodriguez, R. Silva-Medina, E. Gomez-Sandoval, N. Gomez-Gonzalez, R. Soriano-Orozco, P. L. Gonzalez-Carrillo, M. Hernández-Flores, K. Pilarczyk, J. Lubarksi, D. Wendt, F. Dusse, J. Günter, B. Huschens, E. Demircioglu, H. Jakob, A. Palmaccio, A. M. Dell’Anna, D. L. Grieco, F. Torrini, C. Iaquaniello, F. Bongiovanni, M. Antonelli, L. Toscani, D. Antonakaki, D. Bastoni, M. Jozwiak, F. Depret, J. L. Teboul, J. Alphonsine, C. Lai, C. Richard, X. Monnet, G. Demeter, I. Kertmegi, A. Hasanin, A. Lotfy, A. El-adawy, H. Nassar, S. Mahmoud, A. Abougabal, A. Mukhtar, F. Quinty, S. Habchi, A. Luzi, E. Antok, G. Hernandez, B. Lara, L. Enberg, M. Ortega, P. Leon, C. Kripper, P. Aguilera, E. Kattan, M. Lehmann, S. Sakka, B. Bein, R. M. Schmid, J. Preti, J. Creteur, A. Herpain, J. Marc, F. Trojette, S. Bar, L. Kontar, D. Titeca, J. Richecoeur, B. Gelee, N. Verrier, R. Mercier, E. Lorne, J. Maizel, M. Slama, M. E. Abdelfattah, A. Eladawy, M. A. Ali Elsayed, A. Pedraza Montenegro, E. Monares Zepeda, J. Franco Granillo, J. S. Aguirre Sánchez, G. Camarena Alejo, A. Rugerio Cabrera, A. A. Tanaka Montoya, C. Lee, F. Hatib, M. Cannesson, P. Theerawit, T. Morasert, Y. Sutherasan, G. Zani, S. Mescolini, M. Diamanti, R. Righetti, A. Scaramuzza, M. Papetti, M. Terenzoni, C. Gecele, M. Fusari, K. A. Hakim, A. Chaari, M. Ismail, A. H. Elsaka, T. M. Mahmoud, K. Bousselmi, V. Kauts, W. F. Casey, S. D. Hutchings, D. Naumann, J. Wendon, S. Watts, E. Kirkman, Z. Jian, S. Buddi, J. Settels, P. Bertini, F. Guarracino, C. Trepte, P. Richter, S. A. Haas, V. Eichhorn, J. C. Kubitz, M. S. Soliman, W. I. Hamimy, A. Z. Fouad, A. M. Mukhtar, M. Charlton, L. Tonks, L. Mclelland, T. J. Coats, J. P. Thompson, M. R. Sims, D. Williams, D. Z. Roushdy, R. A. Soliman, R. A. Nahas, M. Y. Arafa, W. T. Hung, C. C. Chiang, W. C. Huang, K. C. Lin, S. C. Lin, C. C. Cheng, P. L. Kang, S. R. Wann, G. Y. Mar, C. P. Liu, M. Lopez Carranza, H. Sancho Fernandez, J. A. Sanchez Roman, F. Lucena, A. Campanario Garcia, A. Loza Vazquez, A. Lesmes Serrano, ARIAM-SEMICYUC Registry Investigators, L. Sayagues Moreira, R. Vidal-Perez, U. Anido Herranz, J. M. Garcia Acuna, C. Pena Gil, J. L. Garcia Allut, P. Rascado Sedes, C. Martin Lopez, E. Saborido Paz, C. Galban Rodriguez, J. R. Gonzalez-Juanatey, A. Vallejo-Baez, M. V. de la Torre-Prados, ARIAM Group, R. Marharaj, K. Gervasio, M. Bottiroli, M. Mondino, D. De Caria, A. Calini, E. Montrasio, F. Milazzo, M. P. Gagliardone, A. Vallejo-Báez, ARIAM group, U. Anido, M. Cheikh-Bouhlel, M. P. R. D. L. Dela Cruz, J. M. Bernardo, F. Galfo, A. Marino, C. C. Chao, P. Hou, C. C. Hung, C. H. Chiang, Y. J. Liou, S. M. Hung, Y. S. Lin, F. Y. Kuo, K. R. Chiou, C. J. Chen, L. S. Yan, C. Y. Liu, H. H. Wang, H. L. Chen, C. K. Ho, S. Grewal, S. Gopal, C. Corbett, A. Wilson, J. Capps, W. Ayoub, A. Lomas, S. Ghani, J. Moore, D. Atkinson, M. Sharman, W. Swinnen, J. Pauwels, K. Mignolet, E. Pannier, A. Koch, T. Sarens, W. Temmerman, A. M. Elmenshawy, A. M. Fayed, M. Elboriuny, E. Hamdy, E. Zakaria, A. C. Falk, A. Petosic, K. Olafsen, H. Wøien, H. Flaatten, K. Sunde, J. J. Cáceres Agra, J. L. Santana Cabrera, J. D. Martín Santana, L. Melián Alzola, H. Rodríguez Pérez, T. Castro Pires, H. Calderón, A. Pereira, S. Castro, C. Granja, I. Norkiene, I. Urbanaviciute, G. Kezyte, D. Ringaitiene, T. Jovaisa, G. Vogel, U. B. Johansson, A. Sandgren, C. Svensen, E. Joelsson-Alm, M. A. Leite, L. D. Murbach, E. F. Osaku, C. R. L. M. Costa, M. Pelenz, N. M. Neitzke, M. M. Moraes, J. L. Jaskowiak, M. M. M. Silva, R. S. Zaponi, L. R. L. Abentroth, S. M. Ogasawara, A. C. Jorge, P. A. D. Duarte, J. Barreto, S. T. Duarte, S. Taba, D. Miglioranza, D. P. Gund, C. F. Lordani, H. Vollmer, M. Gager, C. Waldmann, A. T. Mazzeo, R. Tesio, C. Filippini, M. E. Vallero, C. Giolitti, S. Caccia, M. Medugno, T. Tenaglia, R. Rosato, I. Mastromauro, L. Brazzi, P. P. Terragni, R. Urbino, V. Fanelli, V. M. Ranieri, L. Mascia, J. Ballantyne, L. Paton, P. Perez-Teran, O. Roca, J. C. Ruiz-Rodriguez, A. Zapatero, J. Serra, S. Bianzina, P. Cornara, G. Rodi, G. Tavazzi, M. Pozzi, G. A. Iotti, F. Mojoli, A. Braschi, A. Vishnu, D. Buche, R. Pande, D. L. J. Moolenaar, F. Bakhshi-Raiez, D. A. Dongelmans, N. F. de Keizer, D. W. de Lange, I. Fuentes Fernández, D. Martínez Baño, J. L. Buendía Moreno, R. Jara Rubio, J. Scott, D. Phelan, D. Morely, J. O’Flynn, P. Stapleton, M. Lynch, B. Marsh, E. Carton, C. O’Loughlin, K. C. Cheng, M. I. Sung, M. O. Elghonemi, M. H. Saleh, T. S. Meyhoff, M. Krag, P. B. Hjortrup, M. H. Møller, T. Öhman, T. Sigmundsson, E. Redondo, M. Hallbäck, F. Suarez-Sipmann, H. Björne, C. Hällsjö Sander, KARISMA, D. Chiumello, C. Chiurazzi, M. Brioni, I. Algieri, M. Guanziroli, G. Vergani, T. Tonetti, I. Tomic, A. Colombo, F. Crimella, E. Carlesso, V. Gasparovic, R. El-Sherif, M. Abd Al-Basser, A. Raafat, A. El-Sherif, L. R. A. Schouten, O. L. Cremer, D. S. Y. Ong, G. Amoruso, G. Cinnella, L. D. J. Bos, P. Schmidle, M. Findeisen, P. Hoppmann, J. Jaitner, F. Brettner, T. Lahmer, EXODUS-investigators, G. Rajagopalan, V. Bansal, R. Frank, R. Hinds, J. Levitt, United States Critical Illness and Injury Trials Group/LIPS-B investigators, S. Siddiqui, SICM NICER Group, J. P. Gilbert, K. Sim, C. H. Wang, I. J. Li, W. R. Tang, P. Persona, A. De Cassai, M. Franco, A. Goffi, B. Llorente Ruiz, J. Lujan Varas, R. Molina Montero, C. Pintado Delgado, O. Navarrete, M. Vazquez Mezquita, E. Alonso Peces, M. A. M. Nakamura, L. A. Hajjar, F. R. B. G. Galas, T. A. Ortiz, M. B. P. Amato, L. Bitker, N. Costes, D. Le Bars, F. Lavenne, D. Mojgan, J. C. Richard, D. Massari, M. Gotti, P. Cadringher, A. Zerman, M. Türkoğlu, G. Arık, F. Yıldırım, Z. Güllü, I. Kara, N. Boyacı, B. Basarık Aydoğan, Ü. Gaygısız, K. Gönderen, G. Aygencel, M. Aydoğdu, Z. Ülger, G. Gürsel, J. Riera, C. Maldonado Toral, C. Mazo, M. Martínez, J. Baldirà, L. Lagunes, A. Roman, M. Deu, J. Rello, D. J. Levine, R. M. Mohus, Å. Askim, J. Paulsen, A. Mehl, A. T. Dewan, J. K. Damås, E. Solligård, B. O. Åsvold, Mid-Norway Sepsis Research Center, A. DeWan, O. Aktepe, A. Kara, H. Yeter, A. Topeli, M. Norrenberg, M. Devroey, H. Khader, J. C. Preiser, Z. Tang, C. Qiu, L. Tong, C. Cai, O. Apostolopoulou, J. Y. Moon, M. R. Park, I. S. Kwon, G. R. Chon, J. Y. Ahn, S. J. Kwon, Y. J. Chang, J. Y. Lee, S. Y. Yoon, J. W. Lee, The Korean Chungcheong Critical Care Research Group, M. Kostalas, J. Mckinlay, G. Kooner, G. Dudas, A. Horton, C. Kerr, N. Karanjia, B. Creagh-Brown, N. D. Altintas, S. Izdes, O. Keremoglu, A. Alkan, S. Neselioglu, O. Erel, N. Tardif, T. Gustafsson, K. N. MacEachern, M. Traille, I. Bromberg, S. E. Lapinsky, M. J. Moore, J. L. García-Garmendia, F. Villarrasa-Clemente, F. Maroto-Monserrat, O. Rufo-Tejeiro, V. Jorge-Amigo, M. Sánchez-Santamaría, C. Colón-Pallarés, A. Barrero-Almodóvar, S. Gallego-Lara, C. T. Anthon, R. B. Müller, N. Haase, K. Møller, J. Wetterslev, M. Nakanishi, A. Kuriyama, T. Fukuoka, M. A. Abd el Halim, M. H. Elsaid hafez, A. M. Moktar, H. M. Elazizy, K. Abdel Hakim, M. Elbahr, T. Mahmoud, E. Khalil, W. Casey, S. H. Zaky, A. Rizk, R. Ahmed, G. A. Ospina-Tascón, A. F. Garcia Marin, G. J. Echeverry, W. F. Bermudez, H. J. Madriñan-Navia, J. D. Valencia, E. Quiñonez, A. Marulanda, C. A. Arango-Dávila, A. Bruhn, D. De Backer, D. Orbegozo Cortes, F. Su, J. L. Vincent, L. Tullo, L. Mirabella, P. Di Molfetta, M. Dambrosio, C. Villavicencio Lujan, J. Leache irigoyen, M. Cartanya ferré, R. Carbonell García, M. Ahmed, M. El Ayashi, E. Ayman, M. Salem, S. Fathy, A. Zaghlol, M. F. Aguilar Arzapalo, Å. Valsø, T. Rustøen, I. Schou-Bredal, L. Skogstad, K. Tøien, C. Padilla, Y. Palmeiro, W. Egbaria, R. Kigli, B. Maertens, K. Blot, S. Blot, E. Santana-Santos, E. R. dos Santos, R. E. D. L. Ferretti-Rebustini, R. D. C. C. D. O. dos Santos, R. G. S. Verardino, L. A. Bortolotto, A. M. Doyle, I. Naldrett, J. Tillman, S. Price, P. Pearson, J. Greaves, D. Goodall, A. Berry, A. Richardson, G. O. Odundo, P. Omengo, P. Obonyo, N. M. Chanzu, R. Kleinpell, S. J. Sarris, P. Nedved, M. Heitschmidt, H. Ben-Ghezala, S. Snouda, S. Djobbi, N. K. J. Adhikari, D. Leasa, D. Fergusson, D. A. Mckim, J. Weblin, D. McWilliams, F. Doesburg, F. Cnossen, W. Dieperink, W. Bult, M. W. N. Nijsten, G. A. Galvez-Blanco, C. I. Olvera Guzman, J. Santos Stroud, R. Thomson, M. Llaurado-Serra, A. Lobo-Civico, M. Pi-Guerrero, I. Blanco-Sanchez, A. Piñol-Tena, C. Paños-Espinosa, Y. Alabart-Segura, B. Coloma-Gomez, A. Fernandez-Blanco, F. Braga-Dias, M. Treso-Geira, A. Valeiras-Valero, L. Martinez-Reyes, A. Sandiumenge, M. F. Jimenez-Herrera, CAPCRI Study, R. Prada, P. Juárez, R. Argandoña, J. J. Díaz, C. Sánchez Ramirez, P. Saavedra, S. Ruiz Santana, O. Obukhova, S. Kashiya, I. A. Kurmukov, A. M. Pronina, P. Simeone, L. Puybasset, G. Auzias, O. Coulon, B. Lesimple, G. Torkomian, A. Bartkowska-Sniatkowska, O. Szerkus, D. Siluk, J. Bartkowiak-Wieczorek, J. Rosada-Kurasinska, J. Warzybok, R. Kaliszan, C. Hernandez Caballero, S. Roberts, G. Isgro, D. Hall, G. Guillaume, O. Passouant, F. Dumas, W. Bougouin, B. Champigneulle, M. Arnaout, J. Chelly, J. D. Chiche, O. Varenne, J. P. Mira, E. Marijon, A. Cariou, M. Beerepoot, H. R. Touw, K. Parlevliet, C. Boer, P. W. Elbers, Á. J. Roldán Reina, Y. Corcia Palomo, R. Martín Bermúdez, L. Martín Villén, I. Palacios García, J. R. Naranjo Izurieta, J. B. Pérez Bernal, F. J. Jiménez Jiménez, Cardiac Arrest Group HUVR, F. Cota-Delgado, T. Kaneko, H. Tanaka, M. Kamikawa, R. Karashima, S. Iwashita, H. Irie, S. Kasaoka, O. Arola, R. Laitio, A. Saraste, J. Airaksinen, M. Pietilä, M. Hynninen, J. Wennervirta, M. Bäcklund, E. Ylikoski, P. Silvasti, E. Nukarinen, J. Grönlund, V. P. Harjola, J. Niiranen, K. Korpi, M. Varpula, R. O. Roine, T. Laitio, for the Xe-HYPOTHECA study group, S. Salah, B. G. Hassen, A. Mohamed Fehmi, Y. C. Hsu, J. Barea-Mendoza, C. García-Fuentes, M. Castillo-Jaramillo, H. Dominguez-Aguado, R. Viejo-Moreno, L. Terceros-Almanza, S. Bermejo Aznárez, C. Mudarra-Reche, W. Xu, M. Chico-Fernández, J. C. Montejo-González, K. Crewdson, M. Thomas, M. Merghani, L. Fenner, P. Morgan, D. Lockey, E. J. van Lieshout, B. Oomen, J. M. Binnekade, R. J. de Haan, N. P. Juffermans, M. B. Vroom, R. Algarte, L. Martínez, B. Sánchez, I. Romero, F. Martínez, S. Quintana, J. Trenado, O. Sheikh, D. Pogson, R. Clinton, F. Riccio, A. Arthur, L. Young, A. Sinclair, D. Markopoulou, K. Venetsanou, L. Filippou, E. Salla, S. Stratouli, I. Alamanos, A. H. Guirgis, R. Gutiérrez Rodriguez, M. J. Furones Lorente, I. Macias Guarasa, A. Ukere, S. Meisner, G. Greiwe, B. Opitz, D. Benten, B. Nashan, L. Fischer, C. J. C. Trepte, C. R. Behem, B. Ana, A. Vazir, D. Gibson, M. R. Hadavi, M. Riahi alam, M. R. Sasani, N. Parenti, F. Agrusta, C. Palazzi, B. Pifferi, R. Sganzerla, F. Tagliazucchi, A. Luciani, M. Möller, J. Müller-Engelmann, G. Montag, P. Adams, C. Lange, J. Neuzner, R. Gradaus, K. H. Wodack, F. Thürk, A. D. Waldmann, M. F. Grässler, S. Nishimoto, S. H. Böhm, E. Kaniusas, C. J. Trepte, M. Wallin, F. Suarez Sipman, A. Oldner, L. Colinas, R. Vicho, M. Serna, R. Cuena, A. Canabal, ECOCRITIC group, M. Etman, M. El Bahr, A. El Sakka, A. Arali, O. Bond, P. De Santis, E. Iesu, F. Franchi, S. Scolletta, F. S. Taccone, Z. Marutyan, L. Hamidova, A. Shakotko, V. Movsisyan, I. Uysupova, A. Evdokimov, S. Petrikov, F. J. Redondo Calvo, N. Bejarano, V. Baladron, R. Villazala, J. Redondo, D. Padilla, P. Villarejo, C. Gomez-Gonzalez, S. Mas-Font, A. Puppo-Moreno, M. Herrera-Gutierrez, M. Garcia-Garcia, S. Aldunate-Calvo, NEFROCON Investigators, E. P. Plata-Menchaca, X. L. Pérez-Fernández, M. Estruch, A. Betbese-Roig, P. Cárdenas Campos, M. Rojas Lora, N. D. Toapanta Gaibor, R. S. Contreras Medina, V. D. Gumucio Sanguino, E. J. Casanova, J. Sabater Riera, SIRAKI group, K. Kritmetapak, S. Peerapornratana, P. Kittiskulnam, T. Dissayabutra, P. Susantithapong, K. Praditpornsilpa, K. Tungsanga, S. Eiam-Ong, T. Winkelmann, T. Busch, J. Meixensberger, S. Bercker, E. M. Flores Cabeza, M. Sánchez Sánchez, N. Cáceres Giménez, C. Gutierrez Melón, E. Herrero de Lucas, P. Millán Estañ, M. Hernández Bernal, A. Garcia de Lorenzo y Mateos, P. A. C. Specht, M. Balik, M. Zakharchenko, F. Los, H. Brodska, C. de Tymowski, P. Augustin, M. Desmard, P. Montravers, S. N. Stapel, R. de Boer, H. M. Oudemans, A. Hollinger, T. Schweingruber, F. Jockers, M. Dickenmann, M. Siegemund, Clinical Intensive Care Research Basel, N. Runciman, L. Alban, C. Turrini, T. Sasso, T. Langer, P. Taccone, C. Marenghi, G. Grasselli, P. Wibart, T. Reginault, M. Garcia, B. Barbrel, A. Benard, C. Bader, F. Vargas, H. N. Bui, G. Hilbert, J. M. Serrano Simón, P. Carmona Sánchez, F. Ruiz Ferrón, M. García de Acilu, J. Marin, V. Antonia, L. Ruano, M. Monica, G. Hong, D. H. Kim, Y. S. Kim, J. S. Park, Y. K. Jee, Z. Yu xiang, W. Jia-xing, W. Xiao dan, N. Wen long, W. Yu, Z. Yan, X. Cheng, T. Kobayashi, Y. Onodera, R. Akimoto, A. Sugiura, H. Suzuki, M. Iwabuchi, M. Nakane, K. Kawamae, P. Carmona Sanchez, M. D. Bautista Rodriguez, M. Rodriguez Delgado, V. Martínez de Pinillos Sánchez, A. Mula Gómez, P. Beuret, C. Fortes, M. Lauer, M. Reboul, J. C. Chakarian, X. Fabre, B. Philippon-Jouve, S. Devillez, M. Clerc, N. Rittayamai, M. Sklar, M. Dres, M. Rauseo, C. Campbell, B. West, D. E. Tullis, M. Okada, N. Ahmad, M. Wood, A. Glossop, J. Higuera Lucas, A. Blandino Ortiz, D. Cabestrero Alonso, R. De Pablo Sánchez, L. Rey González, R. Costa, G. Spinazzola, A. Pizza, G. Ferrone, M. Rossi, G. Conti, H. Ribeiro, J. Alves, M. Sousa, P. Reis, C. S. Socolovsky, R. P. Cauley, J. E. Frankel, A. L. Beam, K. O. Olaniran, F. K. Gibbons, K. B. Christopher, J. Pennington, P. Zolfaghari, H. S. King, H. H. Y. Kong, H. P. Shum, W. W. Yan, C. Kaymak, N. Okumus, A. Sari, B. Erdogdu, S. Aksun, H. Basar, A. Ozcan, N. Ozcan, D. Oztuna, J. A. Malmgren, S. Lundin, K. Torén, M. Eckerström, A. Wallin, A. C. Waldenström, for the Section on Ethics of the ESICM, F. C. Riccio, A. C. P. Antonio, A. F. Leivas, F. Kenji, E. James, S. Jonnada, C. S. Gerrard, N. Jones, J. D. Salciccioli, D. C. Marshall, M. Komorowski, A. Hartley, M. C. Sykes, R. Goodson, J. Shalhoub, J. R. Fernández Villanueva, R. Fernández Garda, A. M. López Lago, E. Rodríguez Ruiz, R. Hernández Vaquero, C. Galbán Rodríguez, E. Varo Pérez, C. Hilasque, I. Oliva, G. Sirgo, M. C. Martin, M. Olona, M. C. Gilavert, M. Bodí, C. Ebm, G. Aggarwal, S. Huddart, N. Quiney, S. M. Fernandes, J. Santos Silva, J. Gouveia, D. Silva, R. Marques, H. Bento, A. Alvarez, Z. Costa Silva, D. Díaz Diaz, M. Villanova Martínez, E. Palencia Herrejon, A. Martinez de la Gandara, G. Gonzalo, M. A. Lopez, P. Ruíz de Gopegui Miguelena, C. I. Bernal Matilla, P. Sánchez Chueca, M. D. C. Rodríguez Longares, R. Ramos Abril, A. L. Ruíz Aguilar, R. Garrido López de Murillas, R. Fernández Fernández, P. Morales Laborías, M. A. Díaz Castellanos, M. E. Morales Laborías, J. Park, S. Woo, T. West, E. Powell, A. Rimmer, C. Orford, J. Williams, P. Ruiz de Gopegui Miguelena, R. S. Bourne, R. Shulman, M. Tomlin, G. H. Mills, M. Borthwick, W. Berry, D. García Huertas, F. Manzano, F. Villagrán-Ramírez, A. Ruiz-Perea, C. Rodríguez-Mejías, F. Santiago-Ruiz, M. Colmenero-Ruiz, C. König, B. Matt, A. Kortgen, C. S. Hartog, A. Wong, C. Balan, G. Barker, S. Tachaboon, J. Paratz, G. Kayambu, R. Boots, R. Vlasenko, E. Gromova, S. Loginov, M. Kiselevskiy, Y. Dolgikova, K. B. Tang, C. M. Chau, K. N. Lam, E. Gil, G. Y. Suh, C. M. Park, C. R. Chung, C. H. Lai, Y. J. Cheng, V. Colella, N. Zarrillo, M. D’Amico, F. Forfori, B. Pezza, T. Laddomada, V. Beltramelli, M. L. Pizzaballa, A. Doronzio, B. Balicco, D. Kiers, W. van der Heijden, J. Gerretsen, Q. de Mast, S. el Messaoudi, G. Rongen, M. Gomes, N. P. Riksen, Y. Kashiwagi, K. Hayashi, Y. Inagaki, S. Fujita, A. Blet, M. Sadoune, J. Lemarié, N. Bihry, R. Bern, E. Polidano, R. Merval, J. M. Launay, B. Lévy, J. L. Samuel, J. Hartmann, S. Harm, and V. Weber
Subjects: Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Published: 2016
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12. Nature of even and odd magic angles in helical twisted trilayer graphene

Author: Guerci, Daniele, Mao, Yuncheng, and Mora, Christophe
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Strongly Correlated Electrons
Abstract: Helical twisted trilayer graphene exhibits zero-energy flat bands with large degeneracy in the chiral limit. The flat bands emerge at a discrete set of magic twist angles and feature properties intrinsically distinct from those realized in twisted bilayer graphene. Their degeneracy and the associated band Chern numbers depend on the parity of the magic angles. Two degenerate flat bands with Chern numbers $C_A=2$ and $C_B=-1$ arise at odd magic angles, whereas even magic angles display four flat bands, with Chern number $C_{A/B}=\pm1$, together with a Dirac cone crossing at zero energy. All bands are sublattice polarized. We demonstrate the structure behind these flat bands and obtain analytical expressions for the wavefunctions in all cases. Each magic angle is identified with the vanishing of a zero-mode wavefunction at high-symmetry position and momentum. The whole analytical structure results from whether the vanishing is linear or quadratic for the, respectively, odd and even magic angle. The $C_{3z}$ and $C_{2y}T$ symmetries are shown to play a key role in establishing the flat bands. In contrast, the particle-hole symmetry is not essential, except from gapping out the crossing Dirac cone at even magic angles., Comment: 14 pages, 6 figures
Published: 2023

13. Geometric Stiffness in Interlayer Exciton Condensates

Author: Verma, Nishchhal, Guerci, Daniele, and Queiroz, Raquel
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract: Recent experiments have confirmed the presence of interlayer excitons in the ground state of transition metal dichalcogenide (TMD) bilayers. The interlayer excitons are expected to show remarkable transport properties when they undergo Bose condensation. In this work, we demonstrate that quantum geometry of Bloch wavefunctions plays an important role in the phase stiffness of the Interlayer Exciton Condensate (IEC). Notably, we identify a geometric contribution that amplifies the stiffness, leading to the formation of a robust condensate with an increased BKT temperature. Our results have direct implications for the ongoing experimental efforts on interlayer excitons in materials that have non-trivial quantum geometry. We provide quantitative estimates for the geometric contribution in TMD bilayers through a realistic continuum model with gated Coulomb interaction, and find that the substantially increased stiffness allows for an IEC to be realized at amenable experimental conditions., Comment: improved presentation
Published: 2023
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14. Consensus-driven protocol for transanal irrigation in patients with low anterior resection syndrome and functional constipation

Author: Martellucci, J., Falletto, E., Ascanelli, S., Bondurri, A., Borin, S., Bottini, C., Caproli, E., Carrera, M., Cestaro, G., Chimisso, L., Clarizia, G., Clementi, I., Cornaglia, S., Costa, S., Gallo, G., Guerci, C., Lambiase, C., Lauretta, A., Luffarelli, P., Neri, M. C., Piccolo, D., Rosati, E., Rossitti, P., Spolini, A., Torchia, G., Valloncini, E., Zattoni, D., Zucchi, E., Biotti, P., Cambareri, A., Coniglio, G., Coppola, A., Nepote Fus, K., Graziani, S., Grilli, M., Grego, A., Guerra, E., Livio, E., Manganini, L., Mazzeo, P., Minonne, A., Mirafiori, M., Negri, G., Palazzolo, V., Di Pasquale, C., and Tantolo, V.
Published: 2024
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15. Pain outcomes of outside-the-cage robotic thoracic surgery: a prospective matched-cohort study

Author: Streit, Arthur, Walsh, Lyndon C., Stasiak, Florent, Vautrin, Nicolas, Guerci, Philippe, Seitlinger, Joseph, and Renaud, Stéphane
Published: 2024
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16. Clinical impact of genetic alterations including germline DDX41 mutations in MDS/low-blast count AML patients treated with azacitidine-based regimens

Author: Sébert, Marie, Freiman, Lucie, Chaffaut, Cendrine, Guerci, Agnès, Peterlin, Pierre, Thépot, Sylvain, Beyne-Rauzy, Odile, Park, Sophie, Cluzeau, Thomas, Chermat, Fatiha, Fenaux, Pierre, Preudhomme, Claude, Clappier, Emmanuelle, Chevret, Sylvie, Adès, Lionel, Duployez, Nicolas, and Duchmann, Matthieu
Published: 2024
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17. Chiral model of twisted bilayer graphene realized in a monolayer

Author: Crépel, Valentin, Dunbrack, Aaron, Guerci, Daniele, Bonini, John, and Cano, Jennifer
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Strongly Correlated Electrons
Abstract: We demonstrate that a single layer of graphene subject to a superlattice potential nearly commensurate to a $\sqrt{3} \times \sqrt{3}$ supercell exactly maps to the chiral model of twisted bilayer graphene, albeit with half as many degrees of freedom. We comprehensively review the properties of this ``half-chiral model,'' including the interacting phases stabilized at integer fillings and the effects of substrate-induced symmetry breaking. We list candidate substrates that could produce a superlattice potential on graphene with the correct periodicity to access the flat band limit. Experimental measurements on a half-chiral moire heterostructure, in which valley-skyrmions cannot form, could yield insights on the physics they mediate in twisted bilayer graphene.
Published: 2023
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18. Chern mosaic and ideal flat bands in equal-twist trilayer graphene

Author: Guerci, Daniele, Mao, Yuncheng, and Mora, Christophe
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Strongly Correlated Electrons
Abstract: We study trilayer graphene arranged in a staircase stacking configuration with equal consecutive twist angle. On top of the moir\'e cristalline pattern, a supermoir\'e long-wavelength modulation emerges that we treat adiabatically. For each valley, we find that the two central bands are topological with Chern numbers $C=\pm 1$ forming a Chern mosaic at the supermoir\'e scale. The Chern domains are centered around the high-symmetry stacking points ABA or BAB and they are separated by gapless lines connecting the AAA points, where the spectrum is fully connected. In the chiral limit and at a magic angle of $\theta \sim 1.69^\circ$, we prove that the central bands are exactly flat with ideal quantum curvature at ABA and BAB. Furthermore, we decompose them analytically as a superposition of an intrinsic color-entangled state with $\pm 2$ and a Landau level state with Chern number $\mp 1$. To connect with experimental configurations, we also explore the non-chiral limit with finite corrugation and find that the topological Chern mosaic pattern is indeed robust and the central bands are still well separated from remote bands., Comment: 7+7 pages, 5 figures
Published: 2023

19. Topological superconductivity in doped magnetic moir\'e semiconductors

Author: Crépel, Valentin, Guerci, Daniele, Cano, Jennifer, Pixley, J. H., and Millis, Andrew
Subjects: Condensed Matter - Superconductivity, Condensed Matter - Strongly Correlated Electrons
Abstract: We show that topological superconductivity may emerge upon doping of transition metal dichalcogenide heterobilayers above an integer-filling magnetic state of the topmost valence moir\'e band. The effective attraction between charge carriers is generated by an electric p-wave Feshbach resonance arising from interlayer excitonic physics and has a tuanble strength, which may be large. Together with the low moir\'e carrier densities reachable by gating, this robust attraction enables access to the long-sought p-wave BEC-BCS transition. The topological protection arises from an emergent time reversal symmetry occurring when the magnetic order and long wavelength magnetic fluctuations do not couple different valleys. The resulting topological superconductor features helical Majorana edge modes, leading to half-integer quantized spin-thermal Hall conductivity and to charge currents induced by circularly polarized light or other time-reversal symmetry-breaking fields., Comment: 5+2 pages, 4 figures
Published: 2023
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20. Time-dependent ghost-Gutzwiller non-equilibrium dynamics

Author: Guerci, Daniele, Capone, Massimo, and Lanatà, Nicola
Subjects: Condensed Matter - Strongly Correlated Electrons
Abstract: We introduce the time-dependent ghost Gutzwiller approximation (td-gGA), a non-equilibrium extension of the ghost Gutzwiller approximation (gGA), a powerful variational approach which systematically improves on the standard Gutzwiller method by including auxiliary degrees of freedom. We demonstrate the effectiveness of td-gGA by studying the quench dynamics of the single-band Hubbard model as a function of the number of auxiliary parameters. Our results show that td-gGA captures the relaxation of local observables, in contrast with the time-dependent Gutzwiller method. This systematic and qualitative improvement leads to an accuracy comparable with time-dependent Dynamical Mean-Field Theory which comes at a much lower computational cost. These findings suggest that td-gGA has the potential to enable extensive and accurate theoretical investigations of multi-orbital correlated electron systems in nonequilibrium situations, with potential applications in the field of quantum control, Mott solar cells, and other areas where an accurate account of the non-equilibrium properties of strongly interacting quantum systems is required., Comment: 8 pages, 2 figures
Published: 2023
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21. Medial Gradual Opening Osteotomy of the Tibia With Monolateral External Fixator for Correcting the Varus Deformity of the Tibia

Author: Flavio dos Santos Cerqueira, M.D., Felipe Holanda Junqueira, M.D., Guilherme Blois Vasconcelos Pereira, M.D., Larissa da Silva, M.D., Lucas Braga Teixeira, M.D., David Guerci Maia, M.D., Rafael Gouvea de Moraes Vivas, M.D., Jander Soares de Faria, M.D., Jose Leonardo Rocha de Faria, M.D., M.Sc., Leandro Lemgruber Kropf, M.D., M.Sc., Fernando dos Santos Cerqueira, M.D., M.Sc., Bruno Domenico Leonetti, M.D., and Diego Perez da Motta, M.D., M.Sc.
Subjects: Orthopedic surgery, RD701-811
Abstract: Correction of the varus deformities in the tibia is necessary because of the excessive pressure exerted on the medial compartment of the knee, which intensifies the degenerative process. Correction strategies encompass a variety of approaches and depend on the patient’s individual characteristics, age, soft tissue condition, and the orthopaedic surgeon’s experience with different surgical materials. Size and location of the deformity, whether gradual or acute, play crucial roles in choosing the most appropriate material and shape. The gradual correction is especially indicated for patients with severe deformities, soft tissue involvement, and a history of bone infections. This study aimed to introduce a gradual correction technique for varus deformities in the tibia using a unilateral external fixator and to describe the postoperative follow-up. This technique offers notable advantages, including accurate correction, better patient acceptance, lighter assembly, less risk of pseudarthrosis, and shorter distraction process owing to the use of a single piece. In addition, the operated limb can support the load on the day after surgery, and dynamic follow-up is performed on an outpatient basis.
Published: 2024
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22. Supermoir\'e low-energy effective theory of twisted trilayer graphene

Author: Mao, Yuncheng, Guerci, Daniele, and Mora, Christophe
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics
Abstract: Stacking three monolayers of graphene with a twist generally produces two moir\'e patterns. A moir\'e of moir\'e structure then emerges at larger distance where the three layers periodically realign. We devise here an effective low-energy theory to describe the spectrum at distances larger than the moir\'e lengthscale. In each valley of the underlying graphene, the theory comprises one Dirac cone at the ${\bf \Gamma}_M$ point of the moir\'e Brillouin zone and two weakly gapped points at ${\bf K}_M$ and ${\bf K}'_M$. The velocities and small gaps exhibit a spatial dependence in the moir\'e-of-moir\'e unit cell, entailing a non-abelian connection potential which ensures gauge invariance. The resulting model is numerically solved and a fully connected spectrum is obtained, which is protected by the combination of time-reversal and twofold-rotation symmetries., Comment: 17 pages, 15 figures
Published: 2022
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23. Adopting an Ecosystem Approach to Digitalization-driven Organizational Change ? Actionable Knowledge from a Collaborative Project

Author: Shaba, Emanuela, Guerci, Marco, Canterino, Filomena, Gilardi, Silvia, Cagliano, Raffaella, and Bartezzaghi, Emilio
Published: 2023
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24. Chiral Kondo Lattice in Doped MoTe$_2$/WSe$_2$ Bilayers

Author: Guerci, Daniele, Wang, Jie, Zang, Jiawei, Cano, Jennifer, Pixley, J. H., and Millis, Andrew
Subjects: Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract: We theoretically study the interplay between magnetism and a heavy Fermi liquid in the AB stacked transition metal dichalcogenide bilayer system MoTe$_2$/WSe$_2$ in the regime in which the Mo layer supports localized magnetic moments coupled by interlayer electron tunnelling to a weakly correlated band of itinerant electrons in the W layer. We show that the interlayer electron transfer leads to a chiral Kondo exchange, with consequences including a strong dependence of the Kondo temperature on carrier concentration, a topological hybridization gap and an anomalous Hall effect. The theoretical model exhibits two phases, a small Fermi surface magnet and a large Fermi surface heavy Fermi liquid; the transition between them is first order. A low-energy theory is developed for the the transport properties of the two states. Implications of our results for present and future experiments on MoTe$_2$/WSe$_2$ bilayer heterostructures are discussed., Comment: (7+9) pages, (4+6) figures
Published: 2022
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25. Designer Meron Lattice on the Surface of a Topological Insulator

Author: Guerci, Daniele, Wang, Jie, Pixley, J. H., and Cano, Jennifer
Subjects: Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract: We present a promising route to realize spontaneous magnetic order on the surface of a 3D topological insulator by applying a superlattice potential. The superlattice potential creates tunable van Hove singularities, which, when combined with strong spin-orbit coupling and Coulomb repulsion give rise to a topological meron lattice spin texture. The periodicity of this designer meron lattice can be tuned by varying the periodicity of the superlattice potential. We characterize the magnetic order using Ginzburg-Landau theory and show that the magnetic transition temperature reaches experimentally accessible values. Our work introduces a new direction to realize exotic quantum order by engineering interacting Dirac electrons in a superlattice potential, with promising applications to spintronics., Comment: 11 pages, 5 figures and 2 tables
Published: 2022
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26. High Fidelity RF Clutter Modeling and Simulation

Author: Gogineni, Sandeep, Guerci, Joseph R., Nguyen, Hoan K., Bergin, Jameson S., Kirk, David R., Watson, Brian C., and Rangaswamy, Muralidhar
Subjects: Electrical Engineering and Systems Science - Signal Processing
Abstract: In this paper, we present a tutorial overview of state-of-the-art radio frequency (RF) clutter modeling and simulation (M&S) techniques. Traditional statistical approximation based methods will be reviewed followed by more accurate physics-based stochastic transfer function clutter models that facilitate site-specific simulations anywhere on earth. The various factors that go into the computation of these transfer functions will be presented, followed by several examples across multiple RF applications. Finally, we introduce a radar challenge dataset generated using these tools that can enable testing and benchmarking of all cognitive radar algorithms and techniques., Comment: submitted to IEEE Aerospace and Electronic Systems Magazine
Published: 2022

27. Combination of serum and peritoneal 1.3-beta-d-glucan can rule out intra-abdominal candidiasis in surgical critically ill patients: a multicenter prospective study

Author: Novy, Emmanuel, Rivière, Jérémie, Nguyen, Maxime, Arfeuille, Gaëlle, Louis, Guillaume, Bouhemad, Bélaïd, Pottecher, Julien, Hecketsweiler, Stéphane, Germain, Adeline, Laithier, François-Xavier, Losser, Marie-Reine, Debourgogne, Anne, Bernard, Yohann, Rousseau, Hélène, Baumann, Cédric, Luc, Amandine, Birckener, Julien, Machouart, Marie-Claire, and Guerci, Philippe
Published: 2023
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28. Reappraisal of intra-abdominal candidiasis: insights from peritoneal fluid analysis

Author: Novy, Emmanuel, Esposito, Mathieu, Birckener, Julien, Germain, Adeline, Losser, Marie-Reine, Machouart, Marie-Claire, and Guerci, Philippe
Published: 2023
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29. Thoracic epidural analgesia in intensive care unit patients with acute pancreatitis: the EPIPAN multicenter randomized controlled trial

Author: Jabaudon, Matthieu, Genevrier, Alexandra, Jaber, Samir, Windisch, Olivier, Bulyez, Stéphanie, Laterre, Pierre-François, Escudier, Etienne, Sossou, Achille, Guerci, Philippe, Bertrand, Pierre-Marie, Danin, Pierre-Eric, Bonnassieux, Martin, Bühler, Leo, Heidegger, Claudia Paula, Chabanne, Russell, Godet, Thomas, Roszyk, Laurence, Sapin, Vincent, Futier, Emmanuel, Pereira, Bruno, and Constantin, Jean-Michel
Published: 2023
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30. Is it possible to predict the severity of acute appendicitis? Reliability of predictive models based on easily available blood variables

Author: Afzal, Barza, Cirocchi, Roberto, Dawani, Aruna, Desiderio, Jacopo, Di Cintio, Antonio, Di Nardo, Domenico, Farinacci, Federico, Fung, James, Gemini, Alessandro, Guerci, Lorenzo, Kam, Sen Yin Melina, Lakunina, Svetlana, Madi, Lee, Mazzetti, Stefano, Nadyrshine, Bakhtiar, Shams, Ola, Ranucci, Maria Chiara, Ricci, Francesco, Sharmin, Afroza, Trastulli, Stefano, Yasin, Tanzela, Bond-Smith, Giles, and Tebala, Giovanni D.
Published: 2023
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31. Norepinephrine formulation for equivalent vasopressive score

Author: Mongardon, Nicolas, de Roux, Quentin, Leone, Marc, and Guerci, Philippe
Published: 2023
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32. Combining glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) in patients with type 2 diabetes mellitus (T2DM)

Author: Gourdy, Pierre, Darmon, Patrice, Dievart, François, Halimi, Jean-Michel, and Guerci, Bruno
Published: 2023
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33. Clinical factors affecting short- and long-term mortality in older patients with COVID-19: a retrospective cohort study

Author: Benedetta Pennella, Francesca Rotunno, Martina Mercuri, Marco Guerci, Mauro Molteni, Marta Biancucci, Clelia Berton, Francesca Troian, Paolo Maria Tripodi, Alessia Gilio, Antea Milano, Daniela Dalla Gasperina, Francesco Dentali, Aldo Bonaventura, and Andrea Maria Maresca
Subjects: COVID-19, SARS-CoV-2, older patients, mortality, frailty, Medicine
Abstract: The majority of fatal cases of SARS-CoV-2 was concentrated among older patients. We aimed at assessing risk factors contributing to mortality in this population. A retrospective study including 584 COVID-19 patients aged ≥80 years hospitalized between October 10th 2020 to May 4th 2021 at Ospedale di Circolo (Varese, Italy) and Ospedale Galmarini (Tradate, Italy) was conducted. Evaluation of risk factors associated with in-hospital mortality was the primary endpoint. 509 patients were considered. Median age was 86 [82-89] years. Almost half of the patients (n=241) suffered from ≥3 comorbidities. Overall in-hospital mortality was 39.7% (n=202). Age, chronic kidney disease (CKD), peripheral oxygen saturation at admission, and high-flow oxygen during hospital stay independently predicted in-hospital mortality. Overall mortality at 6 months was 57.8% (n=294) and increased with increasing age and number of comorbidities (P
Published: 2024
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34. Higher-order van Hove singularity in magic-angle twisted trilayer graphene

Author: Guerci, Daniele, Simon, Pascal, and Mora, Christophe
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Strongly Correlated Electrons
Abstract: We study the presence of higher-order van Hove singularities in mirror-symmetric twisted trilayer graphene. This geometry has recently emerged experimentally as a fascinating playground for studying correlated and exotic superconducting phases. We find that the trilayer hosts a zero-energy higher-order van Hove singularity with an exponent -1/3. The singularity is protected by the threefold rotation symmetry and a combined mirror-particle-hole symmetry and it can be tuned with only the twist angle and a perpendicular electric field. It arises from the combined merging of van Hove singularities and Dirac cones at zero energy, beyond the recent classifications of van Hove singularities. Moreover, we find that varying a third parameter such as corrugation brings the system to a topological Lifshitz transition, with anomalous exponent -2/5, separating regions of locally open and closed semiclassical orbits., Comment: 18 pages, 13 figures
Published: 2021
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35. Reappraisal of intra-abdominal candidiasis: insights from peritoneal fluid analysis

Author: Emmanuel Novy, Mathieu Esposito, Julien Birckener, Adeline Germain, Marie-Reine Losser, Marie-Claire Machouart, and Philippe Guerci
Subjects: Secondary peritonitis, Candida, Virulence, Critically ill patient, Pathogenicity, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract: Abstract Background The understanding of high mortality associated with intra-abdominal candidiasis (IAC) remains limited. While Candida is considered a harmless colonizer in the digestive tract, its role as a true pathogen in IAC is still debated. Evidence regarding Candida virulence in the human peritoneal fluid are lacking. We hypothesized that during IAC, Candida albicans develops virulence factors to survive to new environmental conditions. The objective of this observational exploratory monocentric study is to investigate the influence of peritoneal fluid (PF) on the expression of C. albicans virulence using a multimodal approach. Materials and methods A standardized inoculum of a C. albicans (3.106 UFC/mL) reference strain (SC5314) was introduced in vitro into various PF samples obtained from critically ill patients with intra-abdominal infection. Ascitic fluids (AFs) and Sabouraud medium (SBD) were used as control groups. Optical microscopy and conventional culture techniques were employed to assess the morphological changes and growth of C. albicans. Reverse transcriptase qPCR was utilized to quantify the expression levels of five virulence genes. The metabolic production of C. albicans was measured using the calScreener™ technology. Results A total of 26 PF samples from patients with secondary peritonitis were included in the study. Critically ill patients were mostly male (73%) with a median age of 58 years admitted for urgent surgery (78%). Peritonitis was mostly hospital-acquired (81%), including 13 post-operative peritonitis (50%). The infected PF samples predominantly exhibited polymicrobial composition. The findings revealed substantial variability in C. albicans growth and morphological changes in the PF compared to ascitic fluid. Virulence gene expression and metabolic production were dependent on the specific PF sample and the presence of bacterial coinfection. Conclusions This study provides evidence of C. albicans virulence expression in the peritoneal fluid. The observed variability in virulence expression suggests that it is influenced by the composition of PF and the presence of bacterial coinfection. These findings contribute to a better understanding of the complex dynamics of intra-abdominal candidiasis and advocate for personalized approach for IAC patients. Trial registration https://clinicaltrials.gov/ (NCT05264571; February 22, 2022) Graphical Abstract
Published: 2023
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36. Emergency surgical treatment of colonic acute diverticulitis: a multicenter observational study on behalf of the Italian society of colorectal surgery (SICCR) Lombardy committee

Author: Ferrara, Francesco, Guerci, Claudio, Bondurri, Andrea, Spinelli, Antonino, and De Nardi, Paola
Published: 2023
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37. Moir\'e lattice effects on the orbital magnetic response of twisted bilayer graphene and Condon instability

Author: Guerci, Daniele, Simon, Pascal, and Mora, Christophe
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics
Abstract: We analyze the orbital magnetic susceptibility from the band structure of twisted bilayer graphene. Close to charge neutrality, the out-of-plane susceptibility inherits the strong diamagnetic response from graphene. Increasing the doping, a crossover from diamagnetism to paramagnetism is obtained and a logarithmic divergence develops at the van Hove singularity of the Moir\'e lattice in the first band. The enhanced paramagnetism at the van Hove singularity is stronger for relatively large angle but gets suppressed by the flat spectrum towards the vicinity of the first magic angle. A diverging paramagnetic susceptibility indicates an instability towards orbital ferromagnetism with an orbital out-of-plane magnetization and a Landau level structure. The region of instability is however found to be practically very small, parametrically suppressed by the ratio of the electron velocity to the speed of light. We also discuss the in-plane orbital susceptibility at charge neutrality where we find a paramagnetic response and a logarithmic divergence at the magic angle. The paramagnetic response is associated with negative counterflow current in the two layers and does not admit a semiclassical description., Comment: 19 pages, 13 figures
Published: 2021
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38. Correction: Adopting an Ecosystem Approach to Digitalization-driven Organizational Change? Actionable Knowledge from a Collaborative Project

Author: Shaba, Emanuela, Guerci, Marco, Canterino, Filomena, Gilardi, Silvia, Cagliano, Raffaella, and Bartezzaghi, Emilio
Published: 2023
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39. Reflexões sobre a progressividade da política previdenciária no Brasil: uma contribuição ao debate

Author: LUÍS EDUARDO AFONSO, OTÁVIO JOSÉ GUERCI SIDONE, and GERALDO ANDRADE DA SILVA FILHO
Subjects: Previdência social, progressividade, aspectos distributivos, adequação, equidade, Economics as a science, HB71-74
Abstract: RESUMO Este artigo traz uma reflexão sobre a progressividade da política previdenciária no Brasil, com base no debate entre Hoffmann (2021) e Cardoso et al. (2021a, 2021b) feito na REP. As dimensões de adequação e equidade devem ocupar espaço proeminente nesta análise. A literatura empírica, por meio do cálculo da Taxa de Reposição e a Taxa Interna de Retorno, traz evidências de que as aposentadorias do RGPS apresentam progressividade para as dimensões de renda, sexo, escolaridade e espécie de benefício. Já para o RPPS da União, há evidências menos claras de progressividade quanto ao sexo, e evidências de regressividade quanto à renda.
Published: 2023
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40. ENOX2 NADH Oxidase: A BCR-ABL1-Dependent Cell Surface and Secreted Redox Protein in Chronic Myeloid Leukemia

Author: Seda Baykal, Maud Voldoire, Christophe Desterke, Nathalie Sorel, Emilie Cayssials, Hyacinthe Johnson-Ansah, Agnes Guerci-Bresler, Annelise Bennaceur-Griscelli, Jean-Claude Chome, and Ali G. Turhan
Subjects: cml, enox2, biomarker, chronic myeloid leukemia, redox protein, secreted protein, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Objective: Chronic myeloid leukemia (CML) is a disease caused by the acquisition of BCR-ABL1 fusion in hematopoietic stem cells. In this study, we focus on the oncofetal ENOX2 protein as a potential secretable biomarker in CML. Materials and Methods: We used cell culture, western blot, quantitative RT-PCR, ELISA, transcriptome analyses, and bioinformatics techniques to investigate ENOX2 mRNA and protein expression. Results: Western blot analyses of UT-7 and TET-inducible Ba/F3 cell lines demonstrated the upregulation of the ENOX2 protein. BCR-ABL1 was found to induce ENOX2 overexpression in a kinase-dependent manner. We confirmed increased ENOX2 mRNA expression in a cohort of CML patients at diagnosis. In a series of CML patients, ELISA assays showed a highly significant increase of ENOX2 protein levels in the plasma of patients with CML compared to controls. Reanalyzing the transcriptomic dataset confirmed ENOX2 mRNA overexpression in the chronic phase of the disease. Bioinformatic analyses identified several genes whose mRNA expressions were positively correlated with ENOX2 in the context of BCR-ABL1. Some of them encode proteins involved in cellular functions compatible with the growth deregulation observed in CML. Conclusion: Our results highlight the upregulation of a secreted redox protein in a BCR-ABL1-dependent manner in CML. The data presented here suggest that ENOX2, through its transcriptional mechanism, plays a significant role in BCR-ABL1 leukemogenesis.
Published: 2023
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41. Design Thinking and Career Development: A Comparative Study

Author: Clio Dosi, Eric Guerci, Jacek Jakieła, Joanna Świętoniowska, Eleni Vordou, Maria José Varadinov, Matteo Vignoli, Gastão de Jesus Marques, and Joanna Wójcik
Subjects: Mechanical drawing. Engineering graphics, T351-385
Abstract: This study conceives career development as a design process and not as a planning activity. An uncertain and fast-changing professional environment requires adaptation and training in a proper mindset. Since there is no such thing as “expertise” in life, Design methodologies and principles may be helpful for students to develop self-awareness and guidance. This study presents a comparative approach based on Beckman and Barry’s (2007) learning framework of the two main career development methodologies for students based on Design Thinking: “Designing Your Life and BE(A)ST” (BE Aware STudent). Designing Your Life explores design thinking principles and techniques to help individuals create fulfilling and meaningful careers. BE(A)ST is an approach, process, and set of tools that assist students in designing their careers while still at university.
Published: 2024
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42. Prognostic indicators in pituitary adenoma surgery: a comprehensive analysis of surgical outcomes and complications

Author: George Riley, Nicolas Scheyer, Marc Klein, Isabelle Merlot, Bruno Guerci, Elodie Jeanbert, and Lea Demarquet
Subjects: nonfunctioning pituitary adenoma (NFPA), pituitary adenoma (PA), endoscopic endonasal surgery (EES), adenoma, surgery complications and outcome, pronostic and predictive factors, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: ObjectiveThe primary aim of this study was to identify predictive factors associated with onset of de-novo clinically significant pituitary insufficiencies following endoscopic endonasal surgery (EES) for pituitary adenomas. The secondary objective explored the predictive factors of surgical successMethodsA retrospective analysis was conducted on 211 patients who underwent EES. Logistic regression models were employed for the primary and secondary objectives. Patients were stratified into specific groups based on surgical indications and prolactin levels for nuanced analysis.ResultsSignificant predictors for de-novo pituitary insufficiencies included male sex (OR 3.3, CI95% 1.3-8.1, p=0.01), immediate postoperative insufficiencies (OR 5.6, CI95% 2.8-11.1, p
Published: 2024
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43. Superradiant phase transition in electronic systems and emergent topological phases

Author: Guerci, Daniele, Simon, Pascal, and Mora, Christophe
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Strongly Correlated Electrons
Abstract: We derive a general criterion for determining the onset of superradiant phase transition in electronic bands coupled to a cavity field, with possibly electron-electron interactions. For longitudinal superradiance in 2D or genuine 1D systems, we prove that it is always prevented, thereby extending existing no-go theorems. Instead, a superradiant phase transition can occur to a nonuniform transverse cavity field and we give specific examples in non-interacting models, either through Fermi surface nesting or parabolic band touching. Investigating the resulting time-reversal symmetry breaking superradiant states, we find in the former case Fermi surface lifting down to four Dirac points on a square lattice model, with topologically protected zero-modes, and in the latter case topological bands with non-zero Chern number on an hexagonal lattice., Comment: 6 pages, 2 figures and supplementary material
Published: 2020
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44. Thoracic epidural analgesia in intensive care unit patients with acute pancreatitis: the EPIPAN multicenter randomized controlled trial

Author: Matthieu Jabaudon, Alexandra Genevrier, Samir Jaber, Olivier Windisch, Stéphanie Bulyez, Pierre-François Laterre, Etienne Escudier, Achille Sossou, Philippe Guerci, Pierre-Marie Bertrand, Pierre-Eric Danin, Martin Bonnassieux, Leo Bühler, Claudia Paula Heidegger, Russell Chabanne, Thomas Godet, Laurence Roszyk, Vincent Sapin, Emmanuel Futier, Bruno Pereira, Jean-Michel Constantin, and for the EPIPAN study group
Subjects: Acute pancreatitis, Intensive care unit, Epidural analgesia, Ventilator-free days, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract: Abstract Background Findings from preclinical studies and one pilot clinical trial suggest potential benefits of epidural analgesia in acute pancreatitis. We aimed to assess the efficacy of thoracic epidural analgesia, in addition to usual care, in improving clinical outcomes of intensive care unit patients with acute pancreatitis. Methods A multicenter, open-label, randomized, controlled trial including adult patients with a clinical diagnosis of acute pancreatitis upon admission to the intensive care unit. Participants were randomly assigned (1:1) to a strategy combining thoracic epidural analgesia and usual care (intervention group) or a strategy of usual care alone (control group). The primary outcome was the number of ventilator-free days from randomization until day 30. Results Between June 2014 and January 2019, 148 patients were enrolled, and 135 patients were included in the intention-to-treat analysis, with 65 patients randomly assigned to the intervention group and 70 to the control group. The number of ventilator-free days did not differ significantly between the intervention and control groups (median [interquartile range], 30 days [15–30] and 30 days [18–30], respectively; median absolute difference of − 0.0 days, 95% CI − 3.3 to 3.3; p = 0.59). Epidural analgesia was significantly associated with longer duration of invasive ventilation (median [interquartile range], 14 days [5–28] versus 6 days [2–13], p = 0.02). Conclusions In a population of intensive care unit adults with acute pancreatitis and low requirement for intubation, this first multicenter randomized trial did not show the hypothesized benefit of epidural analgesia in addition to usual care. Safety of epidural analgesia in this setting requires further investigation. Trial registration: ClinicalTrials.gov registration number NCT02126332 , April 30, 2014.
Published: 2023
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45. Combining glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) in patients with type 2 diabetes mellitus (T2DM)

Author: Pierre Gourdy, Patrice Darmon, François Dievart, Jean-Michel Halimi, and Bruno Guerci
Subjects: Glucagon-like peptide-1 receptor agonists, Sodium-glucose cotransporter-2 inhibitors, Type 2 diabetes mellitus, Combination therapy, Cardiovascular protection, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Abstract Due to their cardiovascular protective effect, glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) represent breakthrough therapies for type 2 diabetes mellitus (T2DM). In this review article, we discuss the mechanistic and clinical synergies that make the combined use of GLP-1RAs and SGLT2is appealing in patients with T2DM. Overall, the presented cumulative evidence supports the benefits of GLP-1RA plus SGLT2i combination therapy on metabolic-cardiovascular-renal disease in patients with T2DM, with a low hypoglycemia risk. Accordingly, we encourage the adoption of GLP-1RA plus SGLT2i combination therapy in patients with T2DM and established atherosclerotic cardiovascular disease (ASCVD) or multiple risk factors for ASCVD (i.e., age ≥ 55 years, overweight/obesity, dyslipidemia, hypertension, current tobacco use, left ventricular hypertrophy, and/or proteinuria). Regarding renal effects, the evidence of SGLT2is in preventing kidney failure is more abundant than for GLP-1RAs, which showed a beneficial effect on albuminuria but not on hard kidney endpoints. Hence, in case of persistent albuminuria and/or uncontrolled metabolic risks (i.e., inadequate glycemic control, hypertension, overweight/obesity) on SGLT2i therapy, GLP-1RAs should be considered as the preferential add-on therapy in T2DM patients with chronic kidney disease. Despite the potential clinical benefits of GLP-1RA plus SGLT2i combination therapy in patients with T2DM, several factors may delay this combination to become a common practice soon, such as reimbursement and costs associated with polypharmacy. Altogether, when administering GLP-1RA plus SGLT2i combination therapy, it is important to adopt an individualized approach to therapy taking into account individual preferences, costs and coverage, toxicity profile, consideration of kidney function and glucose-lowering efficacy, desire for weight loss, and comorbidities.
Published: 2023
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46. Potassium canrenoate in brain-dead organ donors: a randomised controlled clinical trial protocol (CANREO-PMO)

Author: Nicolas Girerd, Philippe Guerci, Xavier Lepage, Ludovic Merckle, Sophie Girerd, Kevin Duarte, Lilia Belarif, and Frédéric Jaisser
Subjects: Medicine
Abstract: Introduction Ischaemia/reperfusion injuries (IRIs) are associated with poorer survival of kidney grafts from expanded criteria donors. Preclinical studies have shown that mineralocorticoid receptor antagonists (MRAs) prevent acute and chronic post-ischaemic renal dysfunction by limiting IRI. However, data concerning the safety of MRAs in brain-dead donor patients are scarce. We seek to investigate the tolerance of MRAs on the haemodynamics in this population.Methods and analysis CANREO-PMO is a randomised, controlled, single-centre, double-blind study. Brain-dead organ donors hospitalised in intensive care are randomised 1:1 after consent to receive 200 mg potassium canrenoate or its matching placebo every 6 hours until organ procurement. The primary outcome is a hierarchical composite endpoint that includes: (1) cardiocirculatory arrest, (2) the impossibility of kidney procurement, (3) the average hourly dose of norepinephrine/epinephrine between randomisation and departure to the operating room, and (4) the average hourly volume of crystalloids and/or colloids received. Thirty-six patients will be included. The secondary endpoints evaluated among the graft recipients are the: (1) vital status of the kidney graft recipients and serum creatinine level with estimated glomerular filtration rate (GFR) according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) at 3 months after renal transplantation, (2) percentage of patients dependent on dialysis and/or with an estimated GFR
Published: 2023
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47. Probing Majorana zero modes by measuring transport through an interacting magnetic impurity

Author: Guerci, Daniele and Nava, Andrea
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Strongly Correlated Electrons
Abstract: Motivated by recent experiments we consider transport across an interacting magnetic impurity coupled to the Majorana zero mode (MZM) observed at the boundary of a topological superconductor (SC). In the presence of a finite tunneling amplitude we observe hybridization of the MZM with the quantum dot, which is manifested by a half-integer zero-bias conductance $G_0=e^2/2h$ measured on the metallic contacts. The low-energy feature in the conductance drops abruptly by crossing the transition line from the topological to the non-topological superconducting regime. Differently from the in-gap Yu-Shiba-Rosinov-like bound states, which are strongly affected by the on-site impurity Coulomb repulsion, we show that the MZM signature in the conductance is robust and persists even at large values of the interaction. Interestingly, the topological regime is characterized by a vanishing Fano factor, $F=0$, induced by the MZM. Combined measurements of the conductance and the shot noise in the experimental set-up presented in the manuscript allow to detect the topological properties of the superconducting wire and to distinguish the low-energy contribution of a MZM from other possible sources of zero-bias anomaly. Despite being interacting the model is exactly solvable, which allows to have an exact characterization of the charge transport properties of the junction., Comment: 19 pages, 9 figures
Published: 2019
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48. Transport through a magnetic impurity: a slave-spin approach

Author: Guerci, Daniele
Subjects: Condensed Matter - Mesoscale and Nanoscale Physics
Abstract: We study transport across a magnetic impurity by means of a recently developed slave-spin technique that does not require any constraint. Within a conserving mean-field approximation we find a conductance that displays both the known zero-bias anomaly but also the expected peak at bias of order U. We extend the slave-spin mean-field approximation to study the out of equilibrium transient evolution of a quantum dot. We apply the method to investigate the time-evolution of a quantum dot induced by a time-dependent electrochemical potential applied to the contacts. Similarly to the time-dependent Gutzwiller approximation, the mean-field slave-spin dynamics is able to capture dissipation in the leads, so that a steady-state is reached after a characteristic relaxation time., Comment: 13 pages, 6 figures
Published: 2019
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49. Is it possible to predict the severity of acute appendicitis? Reliability of predictive models based on easily available blood variables

Author: Barza Afzal, Roberto Cirocchi, Aruna Dawani, Jacopo Desiderio, Antonio Di Cintio, Domenico Di Nardo, Federico Farinacci, James Fung, Alessandro Gemini, Lorenzo Guerci, Sen Yin Melina Kam, Svetlana Lakunina, Lee Madi, Stefano Mazzetti, Bakhtiar Nadyrshine, Ola Shams, Maria Chiara Ranucci, Francesco Ricci, Afroza Sharmin, Stefano Trastulli, Tanzela Yasin, Giles Bond-Smith, and Giovanni D. Tebala
Subjects: Acute appendicitis, Appendicectomy, Predictive models, Lymphocyte count, c-reactive protein, Albumin, Surgery, RD1-811, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract: Abstract Introduction Recent evidence confirms that the treatment of acute appendicitis is not necessarily surgical, and selected patients with uncomplicated appendicitis can benefit from a non-operative management. Unfortunately, no cost-effective test has been proven to be able to effectively predict the degree of appendicular inflammation as yet, therefore, patient selection is too often left to the personal choice of the emergency surgeon. Our paper aims to clarify if basic and readily available blood tests can give reliable prognostic information to build up predictive models to help the decision-making process. Methods Clinical notes of 2275 patients who underwent an appendicectomy with a presumptive diagnosis of acute appendicitis were reviewed, taking into consideration basic preoperative blood tests and histology reports on the surgical specimens. Variables were compared with univariate and multivariate analysis, and predictive models were created. Results 18.2% of patients had a negative appendicectomy, 9.6% had mucosal only inflammation, 53% had transmural inflammation and 19.2% had gangrenous appendicitis. A strong correlation was found between degree of inflammation and lymphocytes count and CRP/Albumin ratio, both at univariate and multivariate analysis. A predictive model to identify cases of gangrenous appendicitis was developed. Conclusion Low lymphocyte count and high CRP/Albumin ratio combined into a predictive model may have a role in the selection of patients who deserve appendicectomy instead of non-operative management of acute appendicitis.
Published: 2023
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50. The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?

Author: Belinda De Simone, Fikri M. Abu-Zidan, Elie Chouillard, Salomone Di Saverio, Massimo Sartelli, Mauro Podda, Carlos Augusto Gomes, Ernest E. Moore, Susan J. Moug, Luca Ansaloni, Yoram Kluger, Federico Coccolini, Aitor Landaluce-Olavarria, Begoña Estraviz-Mateos, Ana Uriguen-Etxeberria, Alessio Giordano, Alfonso Palmieri Luna, Luz Adriana Hernández Amín, Adriana María Palmieri Hernández, Amanda Shabana, Zakaria Andee Dzulkarnaen, Muhammad Asyraf Othman, Mohamad Ikhwan Sani, Andrea Balla, Rosa Scaramuzzo, Pasquale Lepiane, Andrea Bottari, Fabio Staderini, Fabio Cianchi, Andrea Cavallaro, Antonio Zanghì, Alessandro Cappellani, Roberto Campagnacci, Angela Maurizi, Mario Martinotti, Annamaria Ruggieri, Asri Che Jusoh, Karim Abdul Rahman, Anis Suraya M. Zulkifli, Barbara Petronio, Belén Matías-García, Ana Quiroga-Valcárcel, Fernando Mendoza-Moreno, Boyko Atanasov, Fabio Cesare Campanile, Ilaria Vecchioni, Luca Cardinali, Grazia Travaglini, Elisa Sebastiani, Serge Chooklin, Serhii Chuklin, Pasquale Cianci, Enrico Restini, Sabino Capuzzolo, Giuseppe Currò, Rosalinda Filippo, Michele Rispoli, Daniel Aparicio-Sánchez, Virginia Durán Muñóz-Cruzado, Sandra Dios Barbeito, Samir Delibegovic, Amar Kesetovic, Diego Sasia, Felice Borghi, Giorgio Giraudo, Diego Visconti, Emanuele Doria, Mauro Santarelli, Davide Luppi, Stefano Bonilauri, Ugo Grossi, Giacomo Zanus, Alberto Sartori, Giacomo Piatto, Maurizio De Luca, Domenico Vita, Luigi Conti, Patrizio Capelli, Gaetano Maria Cattaneo, Athanasios Marinis, Styliani-Aikaterini Vederaki, Mehmet Bayrak, Yasemin Altıntas, Mustafa Yener Uzunoglu, Iskender Eren Demirbas, Yuksel Altinel, Serhat Meric, Yunus Emre Aktimur, Derya Salim Uymaz, Nail Omarov, Ibrahim Azamat, Eftychios Lostoridis, Eleni-Aikaterini Nagorni, Antonio Pujante, Gabriele Anania, Cristina Bombardini, Francesco Bagolini, Emre Gonullu, Baris Mantoglu, Recayi Capoglu, Stefano Cappato, Elena Muzio, Elif Colak, Suleyman Polat, Zehra Alan Koylu, Fatih Altintoprak, Zülfü Bayhan, Emrah Akin, Enrico Andolfi, Sulce Rezart, Jae Il Kim, Sung Won Jung, Yong Chan Shin, Octavian Enciu, Elena Adelina Toma, Fabio Medas, Gian Luigi Canu, Federico Cappellacci, Fabrizio D’Acapito, Giorgio Ercolani, Leonardo Solaini, Francesco Roscio, Federico Clerici, Roberta Gelmini, Francesco Serra, Elena Giulia Rossi, Francesco Fleres, Guglielmo Clarizia, Alessandro Spolini, Francesco Ferrara, Gabriela Nita, Jlenia Sarnari, Mahir Gachabayov, Abakar Abdullaev, Gaetano Poillucci, Gian Marco Palini, Simone Veneroni, Gianluca Garulli, Micaela Piccoli, Gianmaria Casoni Pattacini, Francesca Pecchini, Giulio Argenio, Mariano Fortunato Armellino, Giuseppe Brisinda, Silvia Tedesco, Pietro Fransvea, Giuseppe Ietto, Caterina Franchi, Giulio Carcano, Gennaro Martines, Giuseppe Trigiante, Giulia Negro, Gustavo Machain Vega, Agustín Rodríguez González, Leonardo Ojeda, Gaetano Piccolo, Andrea Bondurri, Anna Maffioli, Claudio Guerci, Boo Han Sin, Zamri Zuhdi, Azlanudin Azman, Hussam Mousa, Shadi al Bahri, Goran Augustin, Ivan Romic, Trpimir Moric, Ioannis Nikolopoulos, Jacopo Andreuccetti, Giusto Pignata, Rossella D’Alessio, Jakub Kenig, Urszula Skorus, Gustavo Pereira Fraga, Elcio Shiyoiti Hirano, Jackson Vinícius de Lima Bertuol, Arda Isik, Eray Kurnaz, Mohammad Sohail Asghar, Ameer Afzal, Ali Akbar, Taxiarchis Konstantinos Nikolouzakis, Konstantinos Lasithiotakis, Emmanuel Chrysos, Koray Das, Nazmi Özer, Ahmet Seker, Mohamed Ibrahim, Hytham K. S. Hamid, Ahmed Babiker, Konstantinos Bouliaris, George Koukoulis, Chrysoula-Christina Kolla, Andrea Lucchi, Laura Agostinelli, Antonio Taddei, Laura Fortuna, Carlotta Agostini, Leo Licari, Simona Viola, Cosimo Callari, Letizia Laface, Emmanuele Abate, Massimiliano Casati, Alessandro Anastasi, Giuseppe Canonico, Linda Gabellini, Lorenzo Tosi, Anna Guariniello, Federico Zanzi, Lovenish Bains, Larysa Sydorchuk, Oksana Iftoda, Andrii Sydorchuk, Michele Malerba, Federico Costanzo, Raffaele Galleano, Michela Monteleone, Andrea Costanzi, Carlo Riva, Maciej Walędziak, Andrzej Kwiatkowski, Łukasz Czyżykowski, Piotr Major, Marcin Strzałka, Maciej Matyja, Michal Natkaniec, Maria Rosaria Valenti, Maria Domenica Pia Di Vita, Maria Sotiropoulou, Stylianos Kapiris, Damien Massalou, Massimiliano Veroux, Alessio Volpicelli, Rossella Gioco, Matteo Uccelli, Marta Bonaldi, Stefano Olmi, Matteo Nardi, Giada Livadoti, Cristian Mesina, Theodor Viorel Dumitrescu, Mihai Calin Ciorbagiu, Michele Ammendola, Giorgio Ammerata, Roberto Romano, Mihail Slavchev, Evangelos P. Misiakos, Emmanouil Pikoulis, Dimitrios Papaconstantinou, Mohamed Elbahnasawy, Sherief Abdel-elsalam, Daniel M. Felsenreich, Julia Jedamzik, Nikolaos V. Michalopoulos, Theodoros A. Sidiropoulos, Maria Papadoliopoulou, Nicola Cillara, Antonello Deserra, Alessandro Cannavera, Ionuţ Negoi, Dimitrios Schizas, Athanasios Syllaios, Ilias Vagios, Stavros Gourgiotis, Nick Dai, Rekha Gurung, Marcus Norrey, Antonio Pesce, Carlo Vittorio Feo, Nicolo’ Fabbri, Nikolaos Machairas, Panagiotis Dorovinis, Myrto D. Keramida, Francesk Mulita, Georgios Ioannis Verras, Michail Vailas, Omer Yalkin, Nidal Iflazoglu, Direnc Yigit, Oussama Baraket, Karim Ayed, Mohamed hedi Ghalloussi, Parmenion Patias, Georgios Ntokos, Razrim Rahim, Miklosh Bala, Asaf Kedar, Robert G. Sawyer, Anna Trinh, Kelsey Miller, Ruslan Sydorchuk, Ruslan Knut, Oleksandr Plehutsa, Rumeysa Kevser Liman, Zeynep Ozkan, Saleh Abdel Kader, Sanjay Gupta, Monika Gureh, Sara Saeidi, Mohsen Aliakbarian, Amin Dalili, Tomohisa Shoko, Mitsuaki Kojima, Raira Nakamoto, Semra Demirli Atici, Gizem Kilinc Tuncer, Tayfun Kaya, Spiros G. Delis, Stefano Rossi, Biagio Picardi, Simone Rossi del Monte, Tania Triantafyllou, Dimitrios Theodorou, Tadeja Pintar, Jure Salobir, Dimitrios K. Manatakis, Nikolaos Tasis, Vasileios Acheimastos, Orestis Ioannidis, Lydia Loutzidou, Savvas Symeonidis, Tiago Correia de Sá, Mónica Rocha, Tommaso Guagni, Desiré Pantalone, Gherardo Maltinti, Vladimir Khokha, Wafaa Abdel-elsalam, Basma Ghoneim, José Antonio López-Ruiz, Yasin Kara, Syaza Zainudin, Firdaus Hayati, Nornazirah Azizan, Victoria Tan Phooi Khei, Rebecca Choy Xin Yi, Harivinthan Sellappan, Zaza Demetrashvili, Nika Lekiashvili, Ana Tvaladze, Caterina Froiio, Daniele Bernardi, Luigi Bonavina, Angeles Gil-Olarte, Sebastiano Grassia, Estela Romero-Vargas, Francesco Bianco, Andrew A. Gumbs, Agron Dogjani, Ferdinando Agresta, Andrey Litvin, Zsolt J. Balogh, George Gendrikson, Costanza Martino, Dimitrios Damaskos, Nikolaos Pararas, Andrew Kirkpatrick, Mikhail Kurtenkov, Felipe Couto Gomes, Adolfo Pisanu, Oreste Nardello, Fabrizio Gambarini, Hager Aref, Nicola de’ Angelis, Vanni Agnoletti, Antonio Biondi, Marco Vacante, Giulia Griggio, Roberta Tutino, Marco Massani, Giovanni Bisetto, Savino Occhionorelli, Dario Andreotti, Domenico Lacavalla, Walter L. Biffl, and Fausto Catena
Subjects: Acute cholecystitis, Cholecystectomy, Gangrene, COVID-19, SARS-CoV-2, Laparoscopy, Surgery, RD1-811, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract: Abstract Background The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not. Methods Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not. Results A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p
Published: 2022
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