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WEAVE, the new wide-field, massively multiplexed spectroscopic survey facility for the William Herschel Telescope, will see first light in late 2022. WEAVE comprises a new 2-degree field-of-view prime-focus corrector system, a nearly 1000-multiplex fibre positioner, 20 individually deployable 'mini' integral field units (IFUs), and a single large IFU. These fibre systems feed a dual-beam spectrograph covering the wavelength range 366$-$959\,nm at $R\sim5000$, or two shorter ranges at $R\sim20\,000$. After summarising the design and implementation of WEAVE and its data systems, we present the organisation, science drivers and design of a five- to seven-year programme of eight individual surveys to: (i) study our Galaxy's origins by completing Gaia's phase-space information, providing metallicities to its limiting magnitude for $\sim$3 million stars and detailed abundances for $\sim1.5$ million brighter field and open-cluster stars; (ii) survey $\sim0.4$ million Galactic-plane OBA stars, young stellar objects and nearby gas to understand the evolution of young stars and their environments; (iii) perform an extensive spectral survey of white dwarfs; (iv) survey $\sim400$ neutral-hydrogen-selected galaxies with the IFUs; (v) study properties and kinematics of stellar populations and ionised gas in $z<0.5$ cluster galaxies; (vi) survey stellar populations and kinematics in $\sim25\,000$ field galaxies at $0.3\lesssim z \lesssim 0.7$; (vii) study the cosmic evolution of accretion and star formation using $>1$ million spectra of LOFAR-selected radio sources; (viii) trace structures using intergalactic/circumgalactic gas at $z>2$. Finally, we describe the WEAVE Operational Rehearsals using the WEAVE Simulator., Comment: 41 pages, 27 figures, accepted for publication by MNRAS; updated version including information on individual grants in a revised Acknowledgements section, corrections to the affiliation list, and an updated references list

The mathematical modelling of biological systems has historically followed one of two approaches: comprehensive and minimal. In comprehensive models, the involved biological pathways are modelled independently, then brought together as an ensemble of equations that represents the system being studied, most often in the form of a large system of coupled differential equations. This approach often contains a very large number of tuneable parameters (> 100) where each describes some physical or biochemical subproperty. As a result, such models scale very poorly when assimilation of real world data is needed. Furthermore, condensing model results into simple indicators is challenging, an important difficulty in scenarios where medical diagnosis is required. In this paper, we develop a minimal model of glucose homeostasis with the potential to yield diagnostics for pre-diabetes. We model glucose homeostasis as a closed control system containing a self-feedback mechanism that describes the collective effects of the physiological components involved. The model is analyzed as a planar dynamical system, then tested and verified using data collected with continuous glucose monitors (CGMs) from healthy individuals in four separate studies. We show that, although the model has only a small number (3) of tunable parameters, their distribution across subjects has a consistent distribution both for hyperglycemic and for hypoglycemic episodes.

We present a reanalysis of several years of DIMM data at the site of Dome C, Antarctica, to provide measurements of the coherence time $\tau_0$. Statistics and seasonal behaviour of $\tau_0$ are given at two heights above the ground, 3m and 8m, for the wavelength $\lambda=500$nm. We found an annual median value of $2.9$ms at the height of 8m. A few measurements could also be obtained at the height of 20m and give a median value of 6ms during the period June--September. For the first time, we provide measurements of $\tau_0$ in daytime during the summer, which appears to show the same time dependence as the seeing with a sharp maximum at 5pm local time. Exceptional values of $\tau_0$ above 10ms are met at this particular moment. The continuous slow variations of turbulence conditions during the day offers a natural test bed for a solar adaptive optics system.

The distinction between "healthy" and "unhealthy" patients is commonly based on single, discrete values taken at an isolated point in time (e.g., blood pressure or core temperature). Perhaps a more robust and insightful diagnosis can be obtained by studying the functional interdependence of such indicators and the homeostasis that controls them. This requires quasi-continuous measurements and a procedure to map the data onto a parsimonious control model with a degree of universality. The current research illustrates this approach using glucose homeostasis as a target. Data were obtained from 41 healthy subjects wearing over-the-counter glucose monitors, and projected onto a simple proportional-integral (PI) controller, widely used in engineering applications. The indicators quantifying the control function are clustered for the great majority of subjects, while a few outliers exhibit less efficient homeostasis. Practical implications for healthcare and education are further discussed.

We present wind and temperature profiles at Dome C measured by balloon born sonds during the polar summer. Data from 197 flights have been processed for 4 campaigns between 2000 and 2004. We show the exceptionnal wind conditions at Dome C, Average ground wind speed is 3.6 m/s. We noticed in mid-november the presence of high altitude strong winds (40 m/s) probably due to the polar vortex which disappear in summer. These winds seem to have no effect on seeing measurements made with a DIMM at the same period. Temperature profiles exhibit a minimum at height 5500 m (over the snow surface) that defines the tropopause. Surface layer temperature profile has negative gradient in the first 50 m above ground in the afternoon and a strong inversion layer (5{\deg}C over 50 m) around midnight. Wind profiles are compared with other astronomical sites, and with a meteorological model from Meteo France.

The optical turbulence above Dome C in winter is mainly concentrated in the first tens of meters above the ground. Properties of this so-called surface layer (SL) were investigated during the period 2007-2012 by a set of sonics anemometers placed on a 45 m high tower. We present the results of this long-term monitoring of the refractive index structure constant Cn2 within the SL, and confirm its thickness of 35m. We give statistics of the contribution of the SL to the seeing and coherence time. We also investigate properties of large scale structure functions of the temperature and show evidence of a second inertial zone at kilometric spatial scales.

We present the identification of very low frequency g modes in the asymptotic regime and two important parameters that have long been waited for: the core rotation rate, and the asymptotic equidistant period spacing of these g modes. The GOLF instrument on board the SOHO space observatory has provided two decades of full-disk helioseismic data. In the present study, we search for possible collective frequency modulations that are produced by periodic changes in the deep solar structure. Such modulations provide access to only very low frequency g modes, thus allowing statistical methods to take advantage of their asymptotic properties. For oscillatory periods in the range between 9 and nearly 48 hours, almost 100 g modes of spherical harmonic degree 1 and more than 100 g modes of degree 2 are predicted. They are not observed individually, but when combined, they unambiguouslyprovide their asymptotic period equidistance and rotational splittings, in excellent agreement with the requirements of the asymptotic approximations. Previously, p-mode helioseismology allowed the g-mode period equidistance parameter $P_0$ to be bracketed inside a narrow range, between approximately 34 and 35 minutes. Here, $P_0$ is measured to be 34 min 01 s, with a 1 s uncertainty. The previously unknown g-mode splittings have now been measured from a non-synodic reference with very high accuracy, and they imply a mean weighted rotation of 1277 $\pm$ 10 nHz (9-day period) of their kernels, resulting in a rapid rotation frequency of 1644 $\pm$ 23 nHz (period of one week) of the solar core itself, which is a factor 3.8 $\pm$ 0.1 faster than the rotation of the radiative envelope. The g modes are known to be the keys to a better understanding of the structure and dynamics of the solar core. Their detection with these precise parameters will certainly stimulate a new era of research in this field., Comment: 17 pages, 35 figures

Context: The structure of the inner disk of Herbig Be stars is not well understood. The continuum disks of several Herbig Be stars have inner radii that are smaller than predicted by models of irradiated disks with optically thin holes. Aims: We study the size of the inner disk of the Herbig B[e] star HD 85567 and compare the model radii with the radius suggested by the size-luminosity relation. Methods: The object was observed with the AMBER instrument of the Very Large Telescope Interferometer. We obtained K-band visibilities and closure phases. These measurements are interpreted with geometric models and temperature-gradient models. Results: Using several types of geometric star-disk and star-disk-halo models, we derived inner ring-fit radii in the K band that are in the range of 0.8 - 1.6 AU. Additional temperature-gradient modeling resulted in an extended disk with an inner radius of $0.67^{+0.51}_{-0.21}$ AU, a high inner temperature of $2200^{+750}_{-350}$ K, and a disk inclination of $53^{+15}_{-11}$$^\circ$. Conclusions: The derived geometric ring-fit radii are approximately 3 - 5 times smaller than that predicted by the size-luminosity relation. The small geometric and temperature-gradient radii suggest optically thick gaseous material that absorbs stellar radiation inside the dust disk.

We observed the AGB stars S Ori, GX Mon and R Cnc with the MIDI instrument at the VLTI. We compared the data to radiative transfer models of the dust shells, where the central stellar intensity profiles were described by dust-free dynamic model atmospheres. We used Al2O3 and warm silicate grains. Our S Ori and R Cnc data could be well described by an Al2O3 dust shell alone, and our GX Mon data by a mix of an Al2O3 and a silicate shell. The best-fit parameters for S Ori and R Cnc included photospheric angular diameters Theta(Phot) of 9.7+/-1.0mas and 12.3+/-1.0mas, optical depths tau(V)(Al2O3) of 1.5+/-0.5 and 1.35+/-0.2, and inner radii R(in) of 1.9+/-0.3R(Phot) and 2.2+/-0.3R(Phot), respectively. Best-fit parameters for GX Mon were Theta(Phot)=8.7+/-1.3mas, tau(V)(Al2O3)=1.9+/-0.6, R(in)(Al2O3)=2.1+/-0.3R(Phot), tau(V)(silicate)=3.2+/-0.5, and R(in)(silicate)=4.6+/-0.2R(Phot). Our model fits constrain the chemical composition and the inner boundary radii of the dust shells, as well as the photospheric angular diameters. Our interferometric results are consistent with Al2O3 grains condensing close to the stellar surface at about 2 stellar radii, co-located with the extended atmosphere and SiO maser emission, and warm silicate grains at larger distances of about 4--5 stellar radii. We verified that the number densities of aluminum can match that of the best-fit Al2O3 dust shell near the inner dust radius in sufficiently extended atmospheres, confirming that Al2O3 grains can be seed particles for the further dust condensation. Together with literature data of the mass-loss rates, our sample is consistent with a hypothesis that stars with low mass-loss rates form primarily dust that preserves the spectral properties of Al2O3, and stars with higher mass-loss rate form dust with properties of warm silicates., Comment: 20 pages, 10 figures

Over the past few years a major effort has been put into the exploration of potential sites for the deployment of submillimetre astronomical facilities. Amongst the most important sites are Dome C and Dome A on the Antarctic Plateau, and the Chajnantor area in Chile. In this context, we report on measurements of the sky opacity at 200 um over a period of three years at the French-Italian station, Concordia, at Dome C, Antarctica. We also present some solutions to the challenges of operating in the harsh polar environ- ment. Dome C offers exceptional conditions in terms of absolute atmospheric transmission and stability for submillimetre astron- omy. Over the austral winter the PWV exhibits long periods during which it is stable and at a very low level (0.1 to 0.3 mm). Higher values (0.2 to 0.8 mm) of PWV are observed during the short summer period. Based on observations over three years, a transmission of around 50% at 350 um is achieved for 75% of the time. The 200-um window opens with a typical transmission of 10% to 15% for 25% of the time. Dome C is one of the best accessible sites on Earth for submillimetre astronomy. Observations at 350 or 450 {\mu}m are possible all year round, and the 200-um window opens long enough and with a sufficient transparency to be useful. Although the polar environment severely constrains hardware design, a permanent observatory with appropriate technical capabilities is feasible. Because of the very good astronomical conditions, high angular resolution and time series (multi-year) observations at Dome C with a medium size single dish telescope would enable unique studies to be conducted, some of which are not otherwise feasible even from space.

We obtained 13 epochs of mid-infrared interferometry with the MIDI instrument at the VLTI between April 2004 and July 2007, covering pulsation phases 0.45-0.85 within four cycles. The data are modeled with a radiative transfer model of the dust shell where the central stellar intensity profile is described by a series of dust-free dynamic model atmospheres based on self-excited pulsation models. We examined two dust species, silicate and Al2O3 grains. We performed model simulations using variations in model phase and dust shell parameters to investigate the expected variability of our photometric and interferometric data. The observed visibility spectra do not show any indication of variations as a function of pulsation phase and cycle. The observed photometry spectra may indicate intracycle and cycle-to-cycle variations at the level of 1-2 standard deviations. The best-fitting model for our average pulsation phase of 0.64+/-0.15 includes the dynamic model atmosphere M21n (T_model=2550 K) with a photospheric angular diameter of 7.6+/-0.6 mas, and a silicate dust shell with an optical depth of 2.8+/-0.8, an inner radius of 4.1+/-0.7 R_Phot, and a power-law index of the density distribution of 2.6+/-0.3. The addition of an Al2O3 dust shell did not improve the model fit. The photospheric angular diameter corresponds to a radius of 520^+230_-140 R_sun and an effective temperature of ~ 2420+/-200 K. Our modeling simulations confirm that significant visibility variations are not expected for RR Aql at mid-infrared wavelengths within our uncertainties. We conclude that our RR Aql data can be described by a pulsating atmosphere surrounded by a silicate dust shell. The effects of the pulsation on the mid-infrared flux and visibility values are expected to be less than about 25% and 20%, respectively, and are too low to be detected within our measurement uncertainties., Comment: 16 pages, 14 figures. Accepted for publication in A&A

At an altitude of 3250m and at a latitude of $75^\circ$S, the Italo-French Concordia station was open to winter-over teams in 2005. It is one of the high points of the Antarctic polar plateau. These extreme remote sites are expected to provide exceptional conditions for astronomical observations, specially in the infra-red ranges, given the very cold winter temperatures, averaging well below -60C. Being very flat as highest points of that very broad polar plateau, they are also not subject to the famous katabatic winds that can be devastating on the Antarctic coast, and in fact their mean wind speed along the year are the weakest known on Earth, less than 3 m/s. Besides the resulting absence of danger that such winds would present for large size optical instruments, this situation offers another benefit, which is an excellent free atmosphere seeing above a very thin but turbulent surface layer. This paper emphasizes these seeing peculiarities, but not only. It is presented as simply following a significant fraction of my slide presentation during the meeting., Comment: Contribution in conference "Comprehensive characterization of astronomical sites", held October 4-10, 2010, in Kislovodsk, Russia, 15 pages, 24 figures

Context: The winter seeing at Concordia is essentially bimodal, excellent or quite poor, with relative proportions that depend on altitude above the snow surface. This paper studies the temporal behavior of the good seeing sequences. Aims: An efficient exploitation of extremely good seeing with an adaptive optics system needs long integrations. It is then important to explore the temporal distribution of the fraction of time providing excellent seeing. Methods: Temporal windows of good seeing are created by a simple binary process. Good or bad. Their autocorrelations are corrected for those of the existing data sets, since these are not continuous, being often interrupted by technical problems in addition to the adverse weather gaps. At the end these corrected autocorrelations provide the typical duration of good seeing sequences. This study has to be a little detailed as its results depend on the season, summer or winter. Results: Using a threshold of 0.5 arcsec to define the "good seeing", three characteristic numbers are found to describe the temporal evolution of the good seeing windows. The first number is the mean duration of an uninterrupted good seeing sequence: it is $\tau_0=7.5$ hours at 8 m above the ground (15 hours at 20 m). These sequences are randomly distributed in time, with a negative exponential law of damping time $\tau_1=29$ hours (at elevation 8 m and 20 m). The third number is the mean time between two 29 hours episodes. It is T=10 days at 8 m high (5 days at 20 m)., Comment: 4 pages, 6 figures

This paper analyses 3.5 years of site testing data obtained at Dome C, Antarctica, based on measurements obtained with three DIMMs located at three different elevations. Basic statistics of the seeing and the isoplanatic angle are given, as well as the characteristic time of temporal fluctuations of these two parameters, which we found to around 30 minutes at 8 m. The 3 DIMMs are exploited as a profiler of the surface layer, and provide a robust estimation of its statistical properties. It appears to have a very sharp upper limit (less than 1 m). The fraction of time spent by each telescope above the top of the surface layer permits us to deduce a median height of between 23 m and 27 m. The comparison of the different data sets led us to infer the statistical properties of the free atmosphere seeing, with a median value of 0.36 arcsec. The C_n^2 profile inside the surface layer is also deduced from the seeing data obtained during the fraction of time spent by the 3 telescopes inside this turbulence. Statistically, the surface layer, except during the 3-month summer season, contributes to 95 percent of the total turbulence from the surface level, thus confirming the exceptional quality of the site above it.

Context. Due to its great mass and its rapid formation, Jupiter has played a crucial role in shaping the Solar System. The knowledge of its internal structure would strongly constrain the solar system formation mechanism. Seismology is the most efficient way to probe directly the internal structure of giant planets. Aims. SYMPA is the first instrument dedicated to the observations of free oscillations of Jupiter. Principles and theoretical performance have been presented in paper I. This second paper describes the data processing method, the real instrumental performance and presents the first results of a Jovian observation run, lead in 2005 at Teide Observatory. Methods. SYMPA is a Fourier transform spectrometer which works at fixed optical path difference. It produces Doppler shift maps of the observed object. Velocity amplitude of Jupiter's oscillations is expected below 60 cm/s. Results Despite light technical defects, the instrument demonstrated to work correctly, being limited only by photon noise, after a careful analysis. A noise level of about 12 cm/s has been reached on a 10-night observation run, with 21 % duty cycle, which is 5 time better than previous similar observations. However, no signal from Jupiter is clearly highlighted., Comment: 13 pages, 26 figures

In this work, we present the first AMBER observations, of the Wolf-Rayet and O (WR+O) star binary system y2 Velorum. The AMBER instrument was used with the telescopes UT2, UT3, and UT4 on baselines ranging from 46m to 85m. It delivered spectrally dispersed visibilities, as well as differential and closure phases, with a resolution R = 1500 in the spectral band 1.95-2.17 micron. We interpret these data in the context of a binary system with unresolved components, neglecting in a first approximation the wind-wind collision zone flux contribution. We show that the AMBER observables result primarily from the contribution of the individual components of the WR+O binary system. We discuss several interpretations of the residuals, and speculate on the detection of an additional continuum component, originating from the free-free emission associated with the wind-wind collision zone (WWCZ), and contributing at most to the observed K-band flux at the 5% level. The expected absolute separation and position angle at the time of observations were 5.1±0.9mas and 66±15° respectively. However, we infer a separation of 3.62+0.11-0.30 mas and a position angle of 73+9-11°. Our analysis thus implies that the binary system lies at a distance of 368+38-13 pc, in agreement with recent spectrophotometric estimates, but significantly larger than the Hipparcos value of 258+41-31 pc.

We report on results from the first solar Fitting at Low-Angular degree Group (solar FLAG) hare-and-hounds exercise. The group is concerned with the development of methods for extracting the parameters of low-l solar p mode data (`peak bagging'), collected by Sun-as-a-star observations. Accurate and precise estimation of the fundamental parameters of the p modes is a vital pre-requisite of all subsequent studies. Nine members of the FLAG (the `hounds') fitted an artificial 3456-d dataset. The dataset was made by the `hare' (WJC) to simulate full-disc Doppler velocity observations of the Sun. The rotational frequency splittings of the l=1, 2 and 3 modes were the first parameter estimates chosen for scrutiny. Significant differences were uncovered at l=2 and 3 between the fitted splittings of the hounds. Evidence is presented that suggests this unwanted bias had its origins in several effects. The most important came from the different way in which the hounds modeled the visibility ratio of the different rotationally split components. Our results suggest that accurate modelling of the ratios is vital to avoid the introduction of significant bias in the estimated splittings. This is of importance not only for studies of the Sun, but also of the solar analogues that will targets for asteroseismic campaigns.

We present low-resolution turbulence profiles of the atmosphere above Dome C, Antarctica, measured with the MASS instrument during 25 nights in March-May 2004. Except for the lowest layer, Dome C has significantly less turbulence than Cerro Tololo and Cerro Pachon. In particular, the integrated turbulence at 16 km is always less than the median values at the two Chilean sites. From these profiles we evaluate the photometric noise produced by scintillation, and the atmospheric contribution to the error budget in narrow-angle differential astrometry. In comparison with the two mid-latitude sites in Chile, Dome C offers a potential gain of about 3.6 in both photometric precision (for long integrations) and narrow-angle astrometry precision. These gain estimates are preliminary, being computed with average wind-speed profiles, but the validity of our approach is confirmed by independent data. Although the data from Dome C cover a fairly limited time frame, they lend strong support to expectations that Dome C will offer significant advantages for photometric and astrometric studies., Comment: 12 pages, 5 figures, accepted by PASP 26th April, 2006

The solar magnetism is no more considered as a purely superficial phenomenon. The SoHO community has shown that the length of the solar cycle depends on the transition region between radiation and convection. Nevertheless, the internal solar (stellar) magnetism stays poorly known. Starting in 2008, the American instrument HMI/SDO and the European microsatellite PICARD will enrich our view of the Sun-Earth relationship. Thus obtaining a complete MHD solar picture is a clear objective for the next decades and it requires complementary observations of the dynamics of the radiative zone. For that ambitious goal, space prototypes are being developed to improve gravity mode detection. The Sun is unique to progress on the topology of deep internal magnetic fields and to understand the complex mechanisms which provoke photospheric and coronal magnetic changes and possible longer cycles important for human life. We propose the following roadmap in Europe to contribute to this "impressive" revolution in Astronomy and in our Sun-Earth relationship: SoHO (1995-2007), PICARD (2008-2010), DynaMICS (2009-2017) in parallel to SDO (2008-2017) then a world-class mission located at the L1 orbit or above the solar poles., Comment: 10 pages, 8 figures, will appear in the proceedings of 2005 ESLAB symposium 19-21 April 2005

The GOLFNG (Global Oscillations at Low Frequency New Generation) instrument is devoted to the search for solar gravity and acoustic modes, and also chromospheric modes from space. This instrument which is a successor to GOLF/SOHO will contribute to improve our knowledge of the dynamics of the solar radiative zone. It is a 15 points resonant scattering spectrometer, working on the D1 sodium line. A ground-based prototype is under construction to validate the difficult issues. It will be installed at the Teide Observatory, on Tenerife in 2006 to analyse the separation of the effects of the magnetic turbulence of the line from the solar oscillations. We are prepared to put a space version of this instrument including a capability of identification of the modes, in orbit during the next decade. This instrument should be included in the ILWS program as it offers a key to the improvement of our knowledge of the solar core in combination with observations from SDO and PICARD. We hope to determine the core rotation and magnetic field, through precise measurements of oscillation mode frequency splittings. Understanding the magnetic field of the radiative zone is important for progress in the study of solar activity sources, an important player for the long-term Sun-Earth relationship., Comment: Accepted in Advances in Space Research

We report site testing results obtained in night-time during the polar autumn and winter at Dome C. These results were collected during the first Concordia winterover by A. Agabi. They are based upon seeing and isoplanatic angle monitoring, as well as in-situ balloon measurements 2 of the refractive index structure constant profiles Cn (h). Atmosphere is divided into two regions: (i) a 36 m high surface layer responsible of 87% of the turbulence and (ii) a very stable free atmosphere above with a median seeing of 0.36+-0.19 arcsec at an elevation of h = 30 m. The median seeing measured with a DIMM placed on top of a 8.5 m high tower is 1.3+-0.8 arcsec., Comment: accepted for publication in PASP (oct 2005)

We present summer site testing results based on DIMM data obtained at Dome C, Antarctica. These data have been collected on the bright star Canopus during two 3-months summer campaigns in 2003-2004 and 2004-2005. We performed continuous monitoring of the seeing a nd the isoplanatic angle in the visible. We found a median seeing of 0.54 \arcsec and a median isoplanatic angle of 6.8 \arcsec. The seeing appears to have a deep minimum around 0.4 \arcsec almost every day in late afternoon.