662 results on '"P. Ferriani"'
Search Results
2. Evaluation of Sexual Function of Transgender Individuals
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Barcelos, Thays Marina Roncato, de Oliveira Brito, Luiz Gustavo, Jorge, Cristine Homsi, Franceschini, Silvio Antonio, Troncon, Julia Kefalas, Ferriani, Rui Alberto, and da Silva Lara, Lucia Alves
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- 2024
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3. Designing a molecular magnetic button based on 4d and 5d transition-metal phthalocyanines
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P. Ferriani, S. Heinze, and V. Bellini
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Medicine ,Science - Abstract
Abstract The field of molecular spintronics exploits the properties of organic molecules possessing a magnetic moment, either native in the form of radicals or induced by the insertion of transition metal magnetic ions. To realize logic or storage molecular spin-tronics devices, molecules with stable different magnetic states should be deposited on a substrate, and switching between the states controllably achieved. By means of a first-principles calculations, we have devised a functional molecule exhibiting different magnetic states upon structural changes induced by current injection. We investigate the prototypical case of non-planar M-Phthalocyanine (MPc), where M is a transition-metal ion belonging to the 4d and 5d series. We find that for ZrPc and HfPc deposited on a graphene decorated Ni(111) substrate, two different structural conformations could be stabilized, for which the molecules attain different magnetic states depending on the position of the M ion – whether above the Pc or between the Pc and the substrate –, acting therefore as molecular magnetic button. Our work indicates an intuitive way to engineer a magnetic molecular switch with tailored properties, starting from the knowledge of the basic atomic properties of elements and surfaces.
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- 2017
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4. Obesity contributes to telomere shortening in polycystic ovary syndrome
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Kogure, Gislaine Satyko, Verruma, Carolina Gennari, Santana, Barbara A., Calado, Rodrigo T., Ferriani, Rui Alberto, Furtado, Cristiana Libardi Miranda, and dos Reis, Rosana Maria
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- 2024
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5. Developmental lung disease in a cat associated with high probability of severe pulmonary hypertension: natural history, histopathology and genetic analysis.
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Nebel, Yari, Williams, Kurt, Lyons, Leslie, Reinero, Carol, Ferriani, Riccardo, Toschi Corneliani, Roberto, and Spalla, Ilaria
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Congenital lung disease ,FOXF1 ,congestive heart failure ,feline diffuse lung disease ,lung biopsy - Abstract
CASE SUMMARY: This report describes the diagnostic findings, natural history and genetic analysis of the candidate gene Forkhead Box F1 (FOXF1) in a young cat with developmental lung disease and high probability of pulmonary hypertension. A 1-year-old male entire Chartreux cat was referred for cardiac murmur investigation and exercise intolerance. Echocardiography identified a high-velocity tricuspid regurgitant jet with right-sided cardiac changes, supporting a high probability of pulmonary hypertension. No congenital cardiac shunts or left-sided cardiac changes were found to support a primary cardiac cause of pulmonary hypertension. Extensive laboratory work, thoracic radiographs and CT were performed. Histopathological characterisation (lung biopsy and later post mortem) was necessary to reach the final diagnosis. Eight months after diagnosis, the cat developed right-sided congestive heart failure, eventually leading to euthanasia. Survival from diagnosis to death was 12 months. RELEVANCE AND NOVEL INFORMATION: Developmental lung disease belongs to a group of diffuse lung diseases in humans associated with pulmonary hypertension. The veterinary literature describing lung growth disorders in cats is sparse, and the present report provides information on clinical presentation and progression alongside a thorough diagnostic workup, which may aid clinicians in identifying this condition. Lung biopsy was pivotal in reaching the final diagnosis. No causal variants in FOXF1 were identified.
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- 2024
6. Childhood-onset systemic lupus erythematosus (cSLE) and malignancy: a nationwide multicentre series review
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Brufatto, Matheus Zanata, Lanças, Sean Hideo Shirata, de Albuquerque Pedrosa Fernandes, Taciana, Sallum, Adriana Maluf Elias, Campos, Lucia Maria Arruda, Sakamoto, Ana Paula, Terreri, Maria Teresa, Sztajnbok, Flavio Roberto, Bica, Blanca Elena Rios Gomes, Ferriani, Virginia Paes Leme, de Carvalho, Luciana Martins, Silva, Clovis Artur Almeida, and Saad-Magalhaes, Claudia
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- 2024
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7. Dysbiosis index and fecal concentrations of sterols, long-chain fatty acids and unconjugated bile acids in dogs with inflammatory protein-losing enteropathy
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Federica Cagnasso, Jan S. Suchodolski, Antonio Borrelli, Franca Borella, Enrico Bottero, Elena Benvenuti, Riccardo Ferriani, M. Katherine Tolbert, Chih-Chun Chen, Paula R. Giaretta, and Paola Gianella
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canine ,fecal long-chain fatty acids ,fecal sterols ,fecal bile acids ,dysbiosis ,Microbiology ,QR1-502 - Abstract
IntroductionCanine protein-losing enteropathy (PLE) is a syndrome characterized by gastrointestinal loss of proteins. While fecal microbiome and metabolome perturbations have been reported in dogs with chronic enteropathy, they have not been widely studied in dogs with PLE. Therefore, the study aims were to investigate gut microbiome and targeted fecal metabolites in dogs with inflammatory PLE (iPLE) and evaluate whether treatment affects these changes at short-term follow-up.MethodsThirty-eight dogs with PLE and histopathological evidence of gastrointestinal inflammation and 47 healthy dogs were enrolled. Fecal samples were collected before endoscopy (T0) and after one month of therapy (T1). Microbiome and metabolome alterations were investigated using qPCR assays (dysbiosis index, DI) and gas chromatography/mass spectrometry (long-chain fatty acids, sterols, unconjugated bile acids), respectively.ResultsMedian (min-max) DI of iPLE dogs was 0.4 (−5.9 to 7.7) and was significantly higher (p < 0.0001) than median DI in healthy dogs [−2.0 (−6.0 to 5.3)]. No significant associations were found between DI and selected clinicopathological variables. DI did not significantly differ between T0 and T1. In iPLE dogs, at T0, myristic, palmitic, linoleic, oleic, cis-vaccenic, stearic, arachidonic, gondoic, docosanoic, erucic, and nervonic acids were significantly higher (p < 0.0001) than healthy dogs. In iPLE dogs, oleic acid (p = 0.044), stearic acid (p = 0.013), erucic acid (p = 0.018) and nervonic acid (p = 0.002) were significantly decreased at T1. At T0, cholesterol and lathosterol (p < 0.0001) were significantly higher in iPLE dogs compared to healthy dogs, while total measured phytosterols were significantly lower (p = 0.001). No significant differences in total sterols, total phytosterols and total zoosterols content were found at T1, compared to T0. At T0, total primary bile acids and total secondary bile acids did not significantly differ between healthy control dogs and iPLE dogs. No significant differences in fecal bile acid content were found at T1.DiscussionDysbiosis and lipid metabolism perturbations were observed in dogs with iPLE. Different therapeutic protocols lead to an improvement of some but not all metabolome perturbations at short-term follow-up.
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- 2024
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8. First description of oesophageal melanoma in a cat and palliative treatment by endoscopic argon plasma coagulation laser
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Riccardo Ferriani, Teresa Bruna Pagano, and Enrico Bottero
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Veterinary medicine ,SF600-1100 - Abstract
Case summary An 11-year-old castrated male domestic shorthair cat presented with chronic regurgitation and weight loss. Despite a 2-month history of weight loss, regurgitation intensified over 4 weeks, occurring with every food intake, even on a semi-liquid diet. Physical examination revealed thinness and dehydration, and a focal oval mass was noted in the middle mediastinum on thoracic radiography. Oesophagoscopy identified a 6 cm neoformation almost completely obstructing the oesophageal lumen. Biopsies were taken and histopathology, positivity to melanoma triple cocktail and PNL-2 by immunohistochemistry led to the diagnosis of melanocytic neoplasm. Palliative debulking with argon plasma coagulation (APC) was performed, significantly improving the cat’s quality of life for 2 months. The cat survived for 107 days after diagnosis. Relevance and novel information This case report describes the first report of melanocytic neoplasia originating from the oesophageal mucosa in a cat. In cats, melanomas outside the eyes are exceedingly rare and oesophageal neoplasms are exceptionally rare in veterinary medicine, particularly melanomas. The diagnosis relied on positive immunohistochemistry markers aligning with previous research. Treatment with APC emerged as a novel, potentially palliative approach, successfully alleviating regurgitation for 3 months. This underscores APC’s potential in feline oesophageal neoplasia palliative care, which deserves further investigation in a broader feline cohort to confirm its efficacy. Overall, this report provides valuable insights into the diagnosis and treatment of oesophageal melanoma in cats.
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- 2024
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9. Childhood-onset systemic lupus erythematosus (cSLE) and malignancy: a nationwide multicentre series review
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Matheus Zanata Brufatto, Sean Hideo Shirata Lanças, Taciana de Albuquerque Pedrosa Fernandes, Adriana Maluf Elias Sallum, Lucia Maria Arruda Campos, Ana Paula Sakamoto, Maria Teresa Terreri, Flavio Roberto Sztajnbok, Blanca Elena Rios Gomes Bica, Virginia Paes Leme Ferriani, Luciana Martins de Carvalho, Clovis Artur Almeida Silva, and Claudia Saad-Magalhaes
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Childhood-onset systemic lupus erithematosus ,Registry ,Malignancy ,Leukaemia ,Lymphoma ,Solid malignancy ,Diseases of the musculoskeletal system ,RC925-935 ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Background Increased malignancy frequency is well documented in adult-systemic lupus erythematosus (SLE), but with limited reports in childhood-onset SLE (cSLE) series. We explored the frequency of malignancy associated with cSLE, describing clinical and demographic characteristics, disease activity and cumulative damage, by the time of malignancy diagnosis. Method A retrospective case-notes review, in a nationwide cohort from 27 Pediatric Rheumatology centres, with descriptive biopsy-proven malignancy, disease activity/damage accrual, and immunosuppressive treatment were compiled in each participating centre, using a standard protocol. Results Of the 1757 cSLE cases in the updated cohort, 12 (0.7%) developed malignancy with median time 10 years after cSLE diagnosis. There were 91% females, median age at cSLE diagnosis 12 years, median age at malignancy diagnosis 23 years. Of all diagnosed malignancies, 11 were single-site, and a single case with concomitant multiple sites; four had haematological (0.22%) and 8 solid malignancy (0.45%). Median (min–max) SLEDAI-2 K scores were 9 (0–38), median (min–max) SLICC/ACR-DI (SDI) score were 1 (1–5) Histopathology defined 1 Hodgkin's lymphoma, 2 non-Hodgkin's lymphoma, 1 acute lymphoblastic leukaemia; 4 gastrointestinal carcinoma, 1 squamous cell carcinoma of the tongue and 1 anal carcinoma; 1 had sigmoid adenocarcinoma and 1 stomach carcinoid; 3 had genital malignancy, being 1 vulvae, 1 cervix and 1 vulvae and cervix carcinomas; 1 had central nervous system oligodendroglioma; and 1 testicle germ cell teratoma. Conclusion Estimated malignancy frequency of 0.7% was reported during cSLE follow up in a multicentric series. Median disease activity and cumulative damage scores, by the time of malignancy diagnoses, were high; considering that reported in adult series.
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- 2024
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10. Resistance and aerobic training increases genome-wide DNA methylation in women with polycystic ovary syndrome
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Cristiana Libardi Miranda Furtado, Megan Hansen, Gislaine Satyko Kogure, Victor Barbosa Ribeiro, Nathanael Taylor, Murilo Racy Soares, Rui Alberto Ferriani, Kenneth Ivan Aston, Timothy Jenkins, and Rosana Maria dos Reis
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Polycystic ovary syndrome ,physical activity ,aerobic training ,resistance training ,DNA methylation ,Genetics ,QH426-470 - Abstract
ABSTRACTPhysical activity is a first-line treatment for polycystic ovary syndrome (PCOS). Resistance or aerobic exercise improves metabolic complications, reproductive outcomes, and quality of life in PCOS. DNA methylation reprogramming during exercise may be the major modifier behind these changes. We sought to evaluate genome-wide DNA methylation changes after supervised resistance and aerobic exercise in women with PCOS. Exercises were performed in 56 women with PCOS (resistance, n = 30; aerobic, n = 26), for 16 weeks (wks), three times per week, in 50-minute to one-hour sessions. Anthropometric indices and hormonal and metabolic parameters were measured before and after training. Genome-wide leukocyte DNA methylation was analysed by Infinium Human MethylationEPIC 850K BeadChip microarrays (Illumina). Both resistance and aerobic exercise improved anthropometric indices, metabolic dysfunction, and hyperandrogenism in PCOS after the training programme, but no differences were observed between the two exercises. Resistance and aerobic exercise increased genome-wide DNA methylation, although resistance changed every category in the CpG island context (islands, shores, shelve, and open sea), whereas aerobic exercise altered CpG shores and the open sea. Using a stringent FDR (>40), 6 significantly differentially methylated regions (DMRs) were observed in the resistance exercise cohort and 14 DRMs in the aerobic cohort, all of which were hypermethylated. The increase in genome-wide DNA methylation may be related to the metabolic and hormonal changes observed in PCOS after resistance and aerobic exercise. Since the mammalian genome is hypermethylated globally to prevent genomic instability and ageing, resistance and aerobic exercise may promote health and longevity through environmentally induced epigenetic changes.
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- 2024
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11. Developmental lung disease in a cat associated with high probability of severe pulmonary hypertension: natural history, histopathology and genetic analysis
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Yari Nebel, Kurt Williams, Leslie A Lyons, Carol Reinero, Riccardo Ferriani, Roberto Toschi Corneliani, and Ilaria Spalla
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Veterinary medicine ,SF600-1100 - Abstract
Case summary This report describes the diagnostic findings, natural history and genetic analysis of the candidate gene Forkhead Box F1 ( FOXF1 ) in a young cat with developmental lung disease and high probability of pulmonary hypertension. A 1-year-old male entire Chartreux cat was referred for cardiac murmur investigation and exercise intolerance. Echocardiography identified a high-velocity tricuspid regurgitant jet with right-sided cardiac changes, supporting a high probability of pulmonary hypertension. No congenital cardiac shunts or left-sided cardiac changes were found to support a primary cardiac cause of pulmonary hypertension. Extensive laboratory work, thoracic radiographs and CT were performed. Histopathological characterisation (lung biopsy and later post mortem) was necessary to reach the final diagnosis. Eight months after diagnosis, the cat developed right-sided congestive heart failure, eventually leading to euthanasia. Survival from diagnosis to death was 12 months. Relevance and novel information Developmental lung disease belongs to a group of diffuse lung diseases in humans associated with pulmonary hypertension. The veterinary literature describing lung growth disorders in cats is sparse, and the present report provides information on clinical presentation and progression alongside a thorough diagnostic workup, which may aid clinicians in identifying this condition. Lung biopsy was pivotal in reaching the final diagnosis. No causal variants in FOXF1 were identified.
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- 2024
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12. The FIGO ovulatory disorders classification system
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Munro, Malcolm G, Balen, Adam H, Cho, SiHyun, Critchley, Hilary OD, Díaz, Ivonne, Ferriani, Rui, Henry, Laurie, Mocanu, Edgar, van der Spuy, Zephne M, and for the FIGO Committee on Menstrual Disorders and Related Health Impacts, and FIGO Committee on Reproductive Medicine
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Contraception/Reproduction ,Clinical Research ,Reproductive health and childbirth ,Good Health and Well Being ,Female ,Gynecology ,Humans ,Polycystic Ovary Syndrome ,Pregnancy ,Uterine Diseases ,anovulation ,ovulatory disorders ,ovulatory disorders classification ,ovulatory dysfunction ,FIGO Committee on Menstrual Disorders and Related Health Impacts ,and FIGO Committee on Reproductive Medicine ,Endocrinology ,and Infertility ,Paediatrics and Reproductive Medicine ,Obstetrics & Reproductive Medicine ,Reproductive medicine - Abstract
Ovulatory disorders are common causes of amenorrhea, abnormal uterine bleeding, and infertility, and are frequent manifestations of polycystic ovary syndrome (PCOS). There are many potential causes and contributors to ovulatory dysfunction that challenge clinicians, trainees, educators, and those who perform basic, translational, clinical, and epidemiological research. Similarly, therapeutic approaches to ovulatory dysfunction potentially involve a spectrum of lifestyle, psychological, medical, and procedural interventions. Collaborative research, effective education, and consistent clinical care remain challenged by the absence of a consensus comprehensive system for classification of these disorders. The existing and complex system, attributed to WHO, was developed more than three decades ago and did not consider more than 30 years of research into these disorders in addition to technical advances in imaging and endocrinology. This manuscript describes the development of a new classification of ovulatory disorders performed under the aegis of the International Federation of Gynecology and Obstetrics (FIGO) and conducted using a rigorously applied Delphi process. The stakeholder organizations and individuals who participated in this process comprised specialty journals, experts at large, national, specialty obstetrical and gynecological societies, and informed lay representatives. After two face-to-face meetings and five Delphi rounds, the result is a three-level multi-tiered system. The system is applied after a preliminary assessment identifies the presence of an ovulatory disorder. The primary level of the system is based on an anatomic model (Hypothalamus, Pituitary, Ovary) that is completed with a separate category for PCOS. This core component of the system is easily remembered using the acronym HyPO-P. Each anatomic category is stratified in the second layer of the system to provide granularity for investigators, clinicians, and trainees using the "GAIN-FIT-PIE" mnemonic (Genetic, Autoimmune, Iatrogenic, Neoplasm; Functional, Infectious and Inflammatory, Trauma and Vascular; Physiological, Idiopathic, Endocrine). The tertiary level allows for specific diagnostic entities. It is anticipated that, if widely adopted, this system will facilitate education, clinical care, and the design and interpretation of research in a fashion that better informs progress in this field. Integral to the deployment of this system is a periodic process of reevaluation and appropriate revision, reflecting an improved understanding of this collection of disorders.
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- 2022
13. Operations-aware novelty detection framework for CNC machine tools: proposal and application
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Macchi, Marco, Cattaneo, Laura, Polenghi, Adalberto, Bruno, Danilo, Mosci, Sofia, Ferriani, Fabio, and Caneva, Roberto
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- 2023
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14. Applying multidimensional computerized adaptive testing to the MSQOL-54: a simulation study
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Giordano, Andrea, Testa, Silvia, Bassi, Marta, Cilia, Sabina, Bertolotto, Antonio, Quartuccio, Maria Esmeralda, Pietrolongo, Erika, Falautano, Monica, Grobberio, Monica, Niccolai, Claudia, Allegri, Beatrice, Viterbo, Rosa Gemma, Confalonieri, Paolo, Giovannetti, Ambra Mara, Cocco, Eleonora, Grasso, Maria Grazia, Lugaresi, Alessandra, Ferriani, Elisa, Nocentini, Ugo, Zaffaroni, Mauro, De Livera, Alysha, Jelinek, George, Solari, Alessandra, and Rosato, Rosalba
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- 2023
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15. A brazilian nationwide multicenter study on deficiency of deaminase-2 (DADA2)
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Melo, Adriana, de Carvalho, Luciana Martins, Ferriani, Virginia Paes Leme, Cavalcanti, André, Appenzeller, Simone, Oliveira, Valéria Rossato, Neto, Herberto Chong, Rosário, Nelson Augusto, de Oliveira Poswar, Fabiano, Guimaraes, Matheus Xavier, Kokron, Cristina Maria, Maia, Rayana Elias, Silva, Guilherme Diogo, Keller, Gabriel, Ferreira, Mauricio Domingues, Vasconcelos, Dewton Moraes, Toledo-Barros, Myrthes Anna Maragna, Barros, Samar Freschi, Neto, Nilton Salles Rosa, Krieger, Marta Helena, Kalil, Jorge, and Mendonça, Leonardo Oliveira
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- 2023
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16. Applying multidimensional computerized adaptive testing to the MSQOL-54: a simulation study
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Andrea Giordano, Silvia Testa, Marta Bassi, Sabina Cilia, Antonio Bertolotto, Maria Esmeralda Quartuccio, Erika Pietrolongo, Monica Falautano, Monica Grobberio, Claudia Niccolai, Beatrice Allegri, Rosa Gemma Viterbo, Paolo Confalonieri, Ambra Mara Giovannetti, Eleonora Cocco, Maria Grazia Grasso, Alessandra Lugaresi, Elisa Ferriani, Ugo Nocentini, Mauro Zaffaroni, Alysha De Livera, George Jelinek, Alessandra Solari, and Rosalba Rosato
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Multiple sclerosis ,Bifactor model ,Item response theory ,Multidimensional computerized adaptive test ,Health-related quality of life ,MSQOL-54 ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract Background The Multiple Sclerosis Quality of Life-54 (MSQOL-54) is one of the most commonly-used MS-specific health-related quality of life (HRQOL) measures. It is a multidimensional, MS-specific HRQOL inventory, which includes the generic SF-36 core items, supplemented with 18 MS-targeted items. Availability of an adaptive short version providing immediate item scoring may improve instrument usability and validity. However, multidimensional computerized adaptive testing (MCAT) has not been previously applied to MSQOL-54 items. We thus aimed to apply MCAT to the MSQOL-54 and assess its performance. Methods Responses from a large international sample of 3669 MS patients were assessed. We calibrated 52 (of the 54) items using bifactor graded response model (10 group factors and one general HRQOL factor). Then, eight simulations were run with different termination criteria: standard errors (SE) for the general factor and group factors set to different values, and change in factor estimates from one item to the next set at
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- 2023
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17. A brazilian nationwide multicenter study on deficiency of deaminase-2 (DADA2)
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Adriana Melo, Luciana Martins de Carvalho, Virginia Paes Leme Ferriani, André Cavalcanti, Simone Appenzeller, Valéria Rossato Oliveira, Herberto Chong Neto, Nelson Augusto Rosário, Fabiano de Oliveira Poswar, Matheus Xavier Guimaraes, Cristina Maria Kokron, Rayana Elias Maia, Guilherme Diogo Silva, Gabriel Keller, Mauricio Domingues Ferreira, Dewton Moraes Vasconcelos, Myrthes Anna Maragna Toledo-Barros, Samar Freschi Barros, Nilton Salles Rosa Neto, Marta Helena Krieger, Jorge Kalil, and Leonardo Oliveira Mendonça
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Autoinflammatory diseases ,ada2 ,Deficiency of adenosine deaminase 2 ,Immune dysregulation ,Diseases of the musculoskeletal system ,RC925-935 ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Introduction The deficiency of ADA2 (DADA2) is a rare autoinflammatory disease provoked by mutations in the ADA2 gene inherited in a recessive fashion. Up to this moment there is no consensus for the treatment of DADA2 and anti-TNF is the therapy of choice for chronic management whereas bone marrow transplantation is considered for refractory or severe phenotypes. Data from Brazil is scarce and this multicentric study reports 18 patients with DADA2 from Brazil. Patients and methods This is a multicentric study proposed by the Center for Rare and Immunological Disorders of the Hospital 9 de Julho - DASA, São Paulo - Brazil. Patients of any age with a confirmed diagnosis of DADA2 were eligible for this project and data on clinical, laboratory, genetics and treatment were collected. Results Eighteen patients from 10 different centers are reported here. All patients had disease onset at the pediatric age (median of 5 years) and most of them from the state of São Paulo. Vasculopathy with recurrent stroke was the most common phenotype but atypical phenotypes compatible with ALPS-like and Common Variable Immunodeficiency (CVID) was also found. All patients carried pathogenic mutations in the ADA2 gene. Acute management of vasculitis was not satisfactory with steroids in many patients and all those who used anti-TNF had favorable responses. Conclusion The low number of patients diagnosed with DADA2 in Brazil reinforces the need for disease awareness for this condition. Moreover, the absence of guidelines for diagnosis and management is also necessary (t).
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- 2023
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18. Selection of reference miRNAs for RT-qPCR assays in endometriosis menstrual blood-derived mesenchymal stem cells.
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Sabrina Yukari Santos Hacimoto, Ana Clara Lagazzi Cressoni, Lilian Eslaine Costa Mendes da Silva, Cristiana Carolina Padovan, Rui Alberto Ferriani, Júlio César Rosa-E-Silva, and Juliana Meola
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Medicine ,Science - Abstract
Choosing appropriate reference genes or internal controls to normalize RT-qPCR data is mandatory for the interexperimental reproducibility of gene expression data obtained by RT-qPCR in most studies, including those on endometriosis. Particularly for miRNAs, the choice for reference genes is challenging because of their physicochemical and biological characteristics. Moreover, the retrograde menstruation theory, mesenchymal stem cells in menstrual blood (MenSCs), and changes in post-transcriptional regulatory processes through miRNAs have gained prominence in the scientific community as important players in endometriosis. Therefore, we originally explored the stability of 10 miRNAs expressions as internal control candidates in conditions involving the two-dimensional culture of MenSCs from healthy women and patients with endometriosis. Here, we applied multiple algorithms (geNorm, NormFinder, Bestkeeper, and delta Ct) to screen reference genes and assessed the comprehensive stability classification of miRNAs using RefFinder. Pairwise variation calculated using geNorm identified three miRNAs as a sufficient number of reference genes for accurate normalization. MiR-191-5p, miR-24-3p, and miR-103a-3p were the best combination for suitable gene expression normalization. This study will benefit similar research, but is also attractive for regenerative medicine and clinics that use MenSCs, miRNA expression, and RT-qPCR.
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- 2024
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19. As vozes do Programa Criança Feliz: desafios e potencialidades
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Lia Brioschi Soares, Fernanda Kimie Tavares Mishima, and Maria das Graças Carvalho Ferriani
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Desenvolvimento Infantil ,Família ,Políticas Públicas ,Winnicott ,Social pathology. Social and public welfare. Criminology ,HV1-9960 - Abstract
Resumo: Realizou-se pesquisa em três municípios com participantes do Programa Criança Feliz (PCF), que visa promover o desenvolvimento integral infantil. Familiares e equipes foram entrevistados, com posterior análise qualitativa, fundamentada pela teoria de Winnicott. Os resultados mostram que burocracia, insegurança jurídica e financeira fragilizam o PCF, enquanto visita domiciliar e fortalecimento de vínculos auxiliaram as famílias a estarem atentas às necessidades infantis.
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- 2023
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20. Type I and type IIb autoimmune chronic spontaneous urticaria: Using common clinical tools for endotyping patients with CSU
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Juliana A. Sella, MD, PhD, Mariana P.L. Ferriani, MD, PhD, Janaina M.L. Melo, MD, PhD, Orlando Trevisan Neto, MD, Maria Eduarda T. Zanetti, MD, Daniel L. Cordeiro, MD, MSc, José E. Lemos, MD, Sebastião A. Barros, Jr., MD, Davi C. Aragon, PhD, and L. Karla Arruda, MD, PhD
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Urticaria ,IgE ,omalizumab ,autoimmunity ,chronic spontaneous urticaria ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Background: Mechanisms triggering the pathogenesis of chronic spontaneous urticaria (CSU) have been identified as type I autoallergic (which is associated with IgE antibodies against autoantigens) and type IIb autoimmune (which is driven by autoantibodies to FceR1 and/or IgE). Objective: Our aim was to define presumptive endotypes in patients with CSU by using tests amenable to use in routine clinical practice. Methods: A retrospective analysis of the medical records of 394 patients with CSU with or without chronic inducible urticaria or angioedema was performed. Patients were assigned to 1 of 4 groups as follows: (1) type I endotype of CSU, if they presented at least 1 of the following: allergic disease, total IgE level of at least 40UI/mL, and positive result of skin tests to inhalant allergen(s), (2) type IIb endotype of CSU, if they presented at least 1 of following: autoimmune disease, low total IgE level less than 40 IU/mL, positive autologous serum skin test result, positive for antinuclear antibodies in a titer of at least 1:160, and elevated level of anti–thyroid peroxidase, (3) overlap of type I/type IIb endotypes of CSU, if they presented with at least 1 marker of both type I and type IIb, and (4) non–type I/type IIb endotype of CSU, if they presented with none of the markers of type I or type IIb. Results: The mean age at onset of symptoms was 34 years; 82.2% of those with CSU were female, and angioedema and chronic inducible urticaria were found in 74.8% and 31.9% of patients, respectively. Of the patients with CSU, 38% presented with the type I endotype and 51% presented with type I/type IIb overlap, whereas 9% presented with the type IIb endotype and 2% presented with the non–type I/type IIb endotype. Eosinopenia was associated with type IIb and type I/type IIb overlap as opposed to the type I and non–type I/type IIb endotypes (P = .02). Conclusions: Most patients with CSU presented with features of the type 1 (autoallergic) endotype, whether associated with type IIb (autoimmune) endotype or not.
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- 2023
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21. Coevolutionary dynamics of a variant of the cyclic Lotka-Volterra model with three-agent interactions
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Palombi, Filippo, Ferriani, Stefano, and Toti, Simona
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Quantitative Biology - Populations and Evolution ,Condensed Matter - Statistical Mechanics ,Nonlinear Sciences - Adaptation and Self-Organizing Systems ,Physics - Physics and Society - Abstract
We study a variant of the cyclic Lotka-Volterra model with three-agent interactions. Inspired by a multiplayer variation of the Rock-Paper-Scissors game, the model describes an ideal ecosystem in which cyclic competition among three species develops through cooperative predation. Its rate equations in a well-mixed environment display a degenerate Hopf bifurcation, occurring as reactions involving two predators plus one prey have the same rate as reactions involving two preys plus one predator. We estimate the magnitude of the stochastic noise at the bifurcation point, where finite size effects turn neutrally stable orbits into erratically diverging trajectories. In particular, we compare analytic predictions for the extinction probability, derived in the Fokker-Planck approximation, with numerical simulations based on the Gillespie stochastic algorithm. We then extend the analysis of the phase portrait to heterogeneous rates. In a well-mixed environment, we observe a continuum of degenerate Hopf bifurcations, generalizing the above one. Neutral stability ensues from a complex equilibrium between different reactions. Remarkably, on a two-dimensional lattice, all bifurcations disappear as a consequence of the spatial locality of the interactions. In the second part of the paper, we investigate the effects of mobility in a lattice metapopulation model with patches hosting several agents. We find that strategies propagate along the arms of rotating spirals, as they usually do in models of cyclic dominance. We observe propagation instabilities in the regime of large wavelengths. We also examine three-agent interactions inducing nonlinear diffusion., Comment: 22 pages, 13 figures. v2: version accepted for publication in EPJB
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- 2019
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22. Expression of the miR-9-5p, miR-125b-5p and its target gene NFKB1 and TRAF6 in childhood-onset systemic lupus erythematosus (cSLE)
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Denise de Queiroga Nascimento, Isaura Isabelle Fonseca Gomes da Silva, Camilla Albertina Dantas Lima, André de Souza Cavalcanti, Luciana Rodrigues Roberti, Rosane Gomes de Paula Queiroz, Virginia Paes Leme Ferriani, Sergio Crovella, Luciana Martins de Carvalho, and Paula Sandrin-Garcia
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csle ,mir-125b ,mir-9 ,inflammation ,gene expression ,Internal medicine ,RC31-1245 - Abstract
Childhood- onset systemic lupus erythematosus (cSLE) is a multisystem inflammatory disease that can lead to severe clinical conditions resulting in early comorbidities. Several genetic, environmental, and immunological factors are known to influence the onset of the disease. MiRNAs have been already considered as potential actors involved in the development and activity of the SLE. Thus, understanding the behavior of these regulators can contribute to clarify the inflammatory process affecting SLE patients. Among miRNAs, miR-125b-5p and miR-9-5p targeting NFKB1 and TRAF6 genes can be involved in the etio-pathogenesis of the disease by modulating inflammation. In this study we evaluated miR-9-5p and miR-125b-5p expression and its target genes NFKB1 and TRAF6 in peripheral blood samples (PBMC) from the 35 cSLE patients and 35 healthy controls. MiRNAs and gene target expression have been evaluated by using RT-PCR with specific TaqMan® probes. Both miR-9-5p [Fold Change (FC) = −2.21; p = 0.002] and miR-125b-5p (FC= −3.30; p
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- 2022
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23. MIR146A and ADIPOQ genetic variants are associated with birth weight in relation to gestational age: a cohort study
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Silva, Lívia Reis, Melo, Anderson Sanches, Salomão, Karina Bezerra, Mazin, Suleimy Cristina, Tone, Luiz Gonzaga, Cardoso, Viviane Cunha, dos Reis, Rosana Maria, Furtado, Cristiana Libardi Miranda, and Ferriani, Rui Alberto
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- 2022
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24. Aerobic physical training impact on adipokines in women with polycystic ovary syndrome – Effects of body fat percentage
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Hugo Celso Dutra de Souza, Stella Vieira Philbois, Tábata de Paula Facioli, Rui Alberto Ferriani, and Ada Clarice Gastaldi
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Polycystic ovary syndrome ,adipokines ,aerobic physical training ,inflammatory markers ,body fat ,Medicine ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
ABSTRACT Objective: We investigated the effects of aerobic training on adipokine concentrations in women with polycystic ovary syndrome (PCOS). Subjects and methods: 120 women, including 60 with PCOS and 60 without PCOS, were divided into six groups (n = 20) based on body fat percentages of 22%-27%, 28%-32%, and 33%-37%. All groups were submitted the same evaluations before and after 16 weeks of aerobic training. These included anthropometric and hemodynamic analyses, cardiopulmonary tests, and laboratory tests. Two-way analysis of variance was performed to evaluate the differences between women with and without PCOS, effect of the body fat percentage, and effect of aerobic training. Results: Body fat and PCOS were associated with high values of blood glucose, insulin, and testosterone. Body fat also reduced adiponectin levels and increased leptin, tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6). In contrast, the PCOS increased only TNF-α and IL-6 levels. In the PCOS group, aerobic training reduced insulin, triglycerides, leptin, and IL-6 levels. It also promoted an increase in adiponectin and high-density lipoprotein levels. However, aerobic training did not alter TNF-α concentrations. Conclusion: The body fat potentiates metabolic impairments that may be harmful to women with PCOS. Aerobic training appears to promote an important beneficial effect on the metabolic regulation of adipokines, except TNF-α.
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- 2022
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25. Dual-energy X-ray absorptiometry and adiposity index are sensitive methods to evaluate central fat accumulation in women with polycystic ovary syndrome and normal body mass index
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Gislaine Satyko Kogure, Victor Barbosa Ribeiro, Maria Célia Mendes, Rui Alberto Ferriani, Cristiana Libardi Miranda Furtado, and Rosana Maria dos Reis
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Dual-energy X-ray absorptiometry ,body mass index ,central obesity ,polycystic ovary syndrome ,Medicine ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
ABSTRACT Objective: This study aimed to determine the differences in body fat distribution and central obesity indicators using dual-energy X-ray absorptiometry (DXA), adiposity indices, and anthropometric indices between women with and without polycystic ovary syndrome (PCOS). Materials and methods: Clinical and laboratory examination history, including transvaginal ultrasound, fasting blood samples, anthropometric measurements, and DXA scans were conducted in 179 women with PCOS (PCOS group) and 100 without PCOS (non-PCOS group). The volunteers were grouped by body mass index (BMI): normal (18-24.9 kg/m2), overweight (25-29.9 kg/m2), or obese (>30 kg/m2). The visceral adiposity index (VAI) and lipid accumulation product (LAP) were calculated, regions of interest (ROIs) were determined, and the fat mass index (FMI) was calculated using DXA. Results: VAI, LAP, ROIs, FMI, and adiposity indices by DXA were higher in women with PCOS and normal BMI. In both PCOS and non-PCOS groups, the ROIs progressively increased from normal BMI to overweight and obese, and from overweight to obese. Obese women with PCOS showed high trunk fat mass. However, obesity was not able to modify these trunk/periphery fat ratios in PCOS from overweight to higher BMI. These variables were associated with the incidence of PCOS. Conclusion: In women with PCOS and normal BMI, both DXA and the adiposity indices, VAI and LAP, are more sensitive methods to evaluate total body fat and fat accumulation in the central abdominal region. It was also observed that as BMI increased, the differences in measurements between women with and without PCOS decreased.
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- 2023
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26. Use of a human wrist blood pressure monitor for arterial blood pressure measurements in normotensive conscious dogs in comparison to veterinary high‐definition oscillometry
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Elisa Martinelli, Riccardo Ferriani, Annamaria Zanaboni, Roberto Toschi Corneliani, and Chiara Locatelli
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blood pressure ,high‐definition oscillometry ,normotensive dogs ,wrist blood pressure monitor ,Veterinary medicine ,SF600-1100 - Abstract
Abstract Background The gold standard in canine blood pressure (BP) measurement is the invasive method; however, non‐invasive blood pressure measurement techniques (NIBP) are more commonly used. The lack of small, lightweight, cheap, fast and portable NIBP still remains a point to improve in the emergency setting. Key Findings A human wrist blood pressure (WBP) device was evaluated in comparison with the veterinary high‐definition oscillometry (HDO) in conscious normotensive dogs. Systolic and diastolic BPs were evaluated in two groups of dogs. The bias, the limits of agreement and correlation between variables were calculated. Twenty‐five and 36 dogs were, respectively, included in Study No. 1 (dogs weighting ≥10 kg) and 2 (dogs weighting ≥20 kg). In both studies, correlation between the two devices was moderate. A better agreement was displayed for diastolic pressure and poor precision for both systolic and diastolic pressures measurements (as determined by wide limits of agreement). The WBP method underestimated both the systolic and diastolic BP with respect to the HDO method. The inclusion of bigger dogs (Study No. 2) with limb circumference more like to human limb dimension did not improve the agreement between considered methods. Significance The human WBP monitor considered is not suitable to replace the commonly used veterinary HDO for in‐clinic BP monitoring in normotensive conscious dogs.
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- 2022
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27. Clinical evaluation and microbiota analysis in 9 dogs with antibiotic‐responsive enteropathy: A prospective comparison study
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Enrico Bottero, Riccardo Ferriani, Elena Benvenuti, Pietro Ruggiero, Simona Astorina, Marco Giraldi, Loris Bertoldi, Giuseppe Benvenuto, Eleonora Sattin, Paola Gianella, and Jan S. Suchodolski
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chronic diarrhea ,dysbiosis ,Enterobacteriaceae ,tylosin ,Veterinary medicine ,SF600-1100 - Abstract
Abstract Background Antibiotic‐responsive enteropathy (ARE) is diagnosed by excluding other causes of diarrhea and when there is a short‐term response to administration of antibiotics. Objectives To characterize the gut microbiota and clinical trend of dogs with suspected ARE and to evaluate the variation in microbiota before (T0), after 30 days (T30) of tylosin treatment, and 30 days after discontinuation of treatment (T60). A further objective was to evaluate whether changes in gut microbiota are related to relapses of diarrhea when the therapy is tapered. Animals Study sample (group A) was composed of 15 dogs with chronic diarrhea, group B was composed of 15 healthy dogs. Group A was given tylosin for 30 days. Methods A multicentric prospective study. Clinical Indexes, fecal score, and samples for microbiota analysis were collected at T0, T30, and T60 in group A and T0 and T30 in group B. The gut microbiota was analyzed via 16S ribosomal RNA gene. Qiime2 version 2020.2 was used to perform bioinformatic analyses, and Alpha‐ and Beta‐diversity were computed. Results Diarrhea recurred after T30 in 9 of 14 dogs, which were classified as affected by ARE. At T0, a difference was noted in the beta‐diversity between groups (Bray Curtis metric P = .006). A T0‐T30 difference in alpha‐diversity was noted in group A (Shannon index P = .001, Faith PD P = .007). Conclusions and Clinical Importance Although tylosin influences the microbiota of dogs with ARE, we failed to find any specific characteristic in the microbiota of dogs with ARE.
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- 2022
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28. Overexpression of miR-200b-3p in Menstrual Blood-Derived Mesenchymal Stem Cells from Endometriosis Women
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de Oliveira, Rafael Zucco, de Oliveira Buono, Fabiana, Cressoni, Ana Clara Lagazzi, Penariol, Letícia Bruna Corrêa, Padovan, Cristiana Carolina, Tozetti, Patricia Aparecida, Poli-Neto, Omero Benedito, Ferriani, Rui Alberto, Orellana, Maristela Delgado, Rosa-e-Silva, Júlio Cesar, and Meola, Juliana
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- 2022
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29. Polycystic Ovary Syndrome: the Epigenetics Behind the Disease
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Eiras, Matheus Credendio, Pinheiro, Daniel Pascoalino, Romcy, Kalil Andrade Mubarac, Ferriani, Rui Alberto, Reis, Rosana Maria Dos, and Furtado, Cristiana Libardi Miranda
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- 2022
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30. Transcriptomic analysis of cumulus cells shows altered pathways in patients with minimal and mild endometriosis
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Da Luz, Caroline Mantovani, Da Broi, Michele Gomes, Koopman, Larissa de Oliveira, Plaça, Jessica Rodrigues, da Silva-Jr, Wilson Araújo, Ferriani, Rui Alberto, Meola, Juliana, and Navarro, Paula Andrea
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- 2022
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31. Spotlight on latent tuberculosis infection screening for juvenile idiopathic arthritis in two countries, comparing high and low risk patients
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Piotto, Daniela, Nicacio, Aline, Neto, Agna, Mourão, Ana Filipa, Oliveira-Ramos, Filipa, Campanilho-Marques, Raquel, Guedes, Margarida, Cabral, Marta, Santos, Maria José, Fonseca, João Eurico, Canhão, Helena, Aikawa, Nádia Emi, Oliveira, Sheila K. F., Ferriani, Virginia P. L., Pileggi, Gecilmara C. S., Magalhães, Claudia S., Silva, Clovis Artur, and Terreri, Maria Teresa
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- 2022
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32. Transcriptomic analysis of cumulus cells shows altered pathways in patients with minimal and mild endometriosis
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Caroline Mantovani Da Luz, Michele Gomes Da Broi, Larissa de Oliveira Koopman, Jessica Rodrigues Plaça, Wilson Araújo da Silva-Jr, Rui Alberto Ferriani, Juliana Meola, and Paula Andrea Navarro
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Medicine ,Science - Abstract
Abstract Endometriosis is a chronic inflammatory disorder that is highly associated with infertility. This association seems to be related to oocyte impairment, mainly in the initial stages of endometriosis (minimal and mild), where no distortions or adhesions are present. Nonetheless, invasive oocyte analyses are not routinely feasible; thus, indirect assessment of oocyte quality is highly desirable, and, in this context, cumulus cells (CCs) may be more suitable targets of analysis. CCs are crucial in oocyte development and could be used as an index of oocyte quality. Therefore, this prospective case–control study aimed to shed light on the infertility mechanisms of endometriosis I/II by analyzing the CCs’ mRNA transcription profile (women with endometriosis I/II, n = 9) compared to controls (women with tubal abnormalities or male factor, n = 9). The transcriptomic analyses of CCs from patients with minimal and mild endometriosis revealed 26 differentially expressed genes compared to the controls. The enrichment analysis evidenced some altered molecular processes: Cytokine-cytokine receptor interactions, Chemokine signaling, TNF signaling, NOD-like receptor signaling, NF-kappa B signaling, and inflammatory response. With the exception of CXCL12, all enriched genes were downregulated in CCs from patients with endometriosis. These findings provide a significant achievement in the field of reproductive biology, directing future studies to discover biomarkers of oocyte quality in endometriosis.
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- 2022
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33. Urinary cortisol‐creatinine ratio in dogs with hypoadrenocorticism
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Francesca Del Baldo, Magda Gerou Ferriani, Walter Bertazzolo, Matteo Luciani, Antonio Maria Tardo, and Federico Fracassi
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Addison's disease ,adrenal insufficiency ,canine ,cortisol ,Veterinary medicine ,SF600-1100 - Abstract
Abstract Background Basal serum cortisol (BSC) ≥2 μg/dL (>55 nmol/L) has high sensitivity but low specificity for hypoadrenocorticism (HA). Objective To determine whether the urinary corticoid:creatinine ratio (UCCR) can be used to differentiate dogs with HA from healthy dogs and those with diseases mimicking HA (DMHA). Animals Nineteen healthy dogs, 18 dogs with DMHA, and 10 dogs with HA. Methods Retrospective study. The UCCR was determined on urine samples from healthy dogs, dogs with DMHA, and dogs with HA. The diagnostic performance of the UCCR was assessed based on receiver operating characteristics (ROC) curves, calculating the area under the ROC curve. Results The UCCR was significantly lower in dogs with HA (0.65 × 10−6; range, 0.33‐1.22 × 10−6) as compared to healthy dogs (3.38 × 10−6; range, 1.11‐17.32 × 10−6) and those with DMHA (10.28 × 10−6; range, 2.46‐78.65 × 10−6) (P
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- 2022
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34. Dzyaloshinskii-Moryia interaction at an antiferromagnetic interface: first-principles study of FeIr bilayers on Rh(001)
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Meyer, Sebastian, Dupé, Bertrand, Ferriani, Paolo, and Heinze, Stefan
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Computational Physics - Abstract
We study the magnetic interactions in atomic layers of Fe and 5d transition-metals such as Os, Ir, and Pt on the (001) surface of Rh using first-principles calculations based on density functional theory. For both stackings of the 5d-Fe bilayer on Rh(001) we observe a transition from an antiferromagnetic to a ferromagnetic nearest-neighbor exchange interaction upon 5d band filling. In the sandwich structure 5d/Fe/Rh(001) the nearest neighbor exchange is significantly reduced. For FeIr bilayers on Rh(001) we consider spin spiral states in order to determine exchange constants beyond nearest neighbors. By including spin-orbit coupling we obtain the Dzyaloshinskii-Moriya interaction (DMI). The magnetic interactions in Fe/Ir/Rh(001) are similar to those of Fe/Ir(001) for which an atomic scale spin lattice has been predicted. However, small deviations between both systems remain due to the different lattice constants and the Rh vs. Ir surface layers. This leads to slightly different exchange constants and DMI and the easy magnetization direction switches from out-of-plane for Fe/Ir(001) to in-plane for Fe/Ir/Rh(001). Therefore a fine tuning of magnetic interactions is possible by using single 5d transition-metal layers which may allow to tailor antiferromagnetic skyrmions in this type of ultrathin films. In the sandwich structure Ir/Fe/Rh(001) we find a strong exchange frustration due to strong hybridization of the Fe layer with both Ir and Rh which drastically reduces the nearest-neighbor exchange. The energy contribution from the DMI becomes extremely large and DMI beyond nearest neighbors cannot be neglected. We attribute the large DMI to the low coordination of the Ir layer at the surface. We demonstrate that higher- order exchange interactions are significant in both systems which may be crucial for the magnetic ground state.
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- 2017
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35. Influence of periodic external fields in multiagent models with language dynamics
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Palombi, Filippo, Ferriani, Stefano, and Toti, Simona
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Physics - Physics and Society ,Condensed Matter - Statistical Mechanics ,Computer Science - Multiagent Systems ,Nonlinear Sciences - Adaptation and Self-Organizing Systems - Abstract
We investigate large-scale effects induced by external fields, phenomenologically interpreted as mass media, in multiagent models evolving with the microscopic dynamics of the binary naming game. In particular, we show that a single external field, broadcasting information at regular time intervals, can reverse the majority opinion of the population, provided the frequency and the effectiveness of the sent messages lie above well-defined thresholds. We study the phase structure of the model in the mean field approximation and in numerical simulations with several network topologies. We also investigate the influence on the agent dynamics of two competing external fields, periodically broadcasting different messages. In finite regions of the parameter space we observe periodic equilibrium states in which the average opinion densities are reversed with respect to naive expectations. Such equilibria occur in two cases: (i) when the frequencies of the competing messages are different but close to each other; (ii) when the frequencies are equal and the relative time shift of the messages does not exceed half a period. We interpret the observed phenomena as a result of the interplay between the external fields and the internal dynamics of the agents and conclude that, depending on the model parameters, the naming game is consistent with scenarios of first- or second-mover advantage (to borrow an expression from the jargon of business strategy)., Comment: 46 pages, 31 figures. v2: version accepted for publication in Physical Review E
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- 2017
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36. Viability of a MSQOL-54 general health-related quality of life score using bifactor model
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Andrea Giordano, Silvia Testa, Marta Bassi, Sabina Cilia, Antonio Bertolotto, Maria Esmeralda Quartuccio, Erika Pietrolongo, Monica Falautano, Monica Grobberio, Claudia Niccolai, Beatrice Allegri, Rosa Gemma Viterbo, Paolo Confalonieri, Ambra Mara Giovannetti, Eleonora Cocco, Maria Grazia Grasso, Alessandra Lugaresi, Elisa Ferriani, Ugo Nocentini, Mauro Zaffaroni, Alysha De Livera, George Jelinek, Alessandra Solari, and Rosalba Rosato
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Multiple sclerosis ,Bifactor model ,Dimensionality ,Factor analyses ,Health-related quality of life ,MSQOL-54 ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract Background MSQOL-54 is a multidimensional, widely-used, health-related quality of life (HRQOL) instrument specific for multiple sclerosis (MS). Findings from the validation study suggested that the two MSQOL-54 composite scores are correlated. Given this correlation, it could be assumed that a unique total score of HRQOL may be calculated, with the advantage to provide key stakeholders with a single overall HRQOL score. We aimed to assess how well the bifactor model could account for the MSQOL-54 structure, in order to verify whether a total HRQOL score can be calculated. Methods A large international database (3669 MS patients) was used. By means of confirmatory factor analysis, we estimated a bifactor model in which every item loads onto both a general factor and a group factor. Fit of the bifactor model was compared to that of single and two second-order factor models by means of Akaike information and Bayesian information criteria reduction. Reliability of the total and subscale scores was evaluated with Mc Donald’s coefficients (omega, and omega hierarchical). Results The bifactor model outperformed the two second-order factor models in all the statistics. All items loaded satisfactorily (≥ 0.40) on the general HRQOL factor, except the sexual function items. Omega coefficients for total score were very satisfactory (0.98 and 0.87). Omega hierarchical for subscales ranged between 0.22 to 0.57, except for the sexual function (0.70). Conclusions The bifactor model is particularly useful when it is intended to acknowledge multidimensionality and at the same time take account of a single general construct, as the HRQOL related to MS. The total raw score can be used as an estimate of the general HRQOL latent score.
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- 2021
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37. Unnecessary Abdominal Surgeries in Attacks of Hereditary Angioedema with Normal C1 Inhibitor
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Gutierrez, Marcel, Veronez, Camila L., Rodrigues Valle, Solange O, Gonçalves, Rozana Fátima, Ferriani, Mariana Paes Leme, Moreno, Adriana S., Arruda, L. Karla, Aun, Marcelo Vivolo, Giavina-Bianchi, Pedro, Alonso, Maria Luiza Oliva, Pesquero, Joao B., and Grumach, Anete S.
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- 2021
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38. Dementia-related genetic variants in an Italian population of early-onset Alzheimer’s disease
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Anna Bartoletti-Stella, Martina Tarozzi, Giacomo Mengozzi, Francesca Asirelli, Laura Brancaleoni, Nicola Mometto, Michelangelo Stanzani-Maserati, Simone Baiardi, Simona Linarello, Marco Spallazzi, Roberta Pantieri, Elisa Ferriani, Paolo Caffarra, Rocco Liguori, Piero Parchi, and Sabina Capellari
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Alzheimer’s disease ,early onset Alzheimer disease ,next generation sequencing ,genetic heterogeneity ,mutation screening ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Early-onset Alzheimer’s disease (EOAD) is the most common form of early-onset dementia. Although three major genes have been identified as causative, the genetic contribution to the disease remains unsolved in many patients. Recent studies have identified pathogenic variants in genes representing a risk factor for developing Alzheimer’s disease (AD) and in causative genes for other degenerative dementias as responsible for EOAD. To study them further, we investigated a panel of candidate genes in 102 Italian EOAD patients, 45.10% of whom had a positive family history and 21.74% with a strong family history of dementia. We found that 10.78% of patients carried pathogenic or likely pathogenic variants, including a novel variant, in PSEN1, PSEN2, or APP, and 7.84% showed homozygosity for the ε4 APOE allele. Additionally, 7.84% of patients had a moderate risk allele in PSEN1, PSEN2, or TREM2 genes. Besides, we observed that 12.75% of our patients carried only a variant in genes associated with other neurodegenerative diseases. The combination of these variants contributes to explain 46% of cases with a definite familiarity and 32% of sporadic forms. Our results confirm the importance of extensive genetic screening in EOAD for clinical purposes, to select patients for future treatments and to contribute to the definition of overlapping pathogenic mechanisms between AD and other forms of dementia.
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- 2022
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39. Gut Microbiota and Lymphocyte Subsets in Canine Leishmaniasis
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Sara Meazzi, Stefania Lauzi, Valeria Martini, Riccardo Ferriani, Margherita Peri, Sergio Aurelio Zanzani, and Alessia Giordano
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Leishmania spp. ,fecal microbiome ,leukocytes ,flow cytometry ,bacteria ,Veterinary medicine ,SF600-1100 - Abstract
Gut microbiota seems to interact with immune system. Canine leishmaniasis pathogenesis and severity of disease lean on the host immunity, but there is no information in literature about gut microbiota in infected animals. Thus, this study aims to compare the microbiota composition and leukocyte subset of healthy dogs with those of asymptomatic dogs exposed to Leishmania spp. and dogs with clinical leishmaniasis. Thirty-nine dogs were enrolled and grouped into three groups: healthy, exposed asymptomatic and infected symptomatic for Leishmania spp. Flow cytometry on whole blood evaluated the prevalence of CD4, CD5, CD8, CD11b, CD14, and CD21 positive cells. Gut microbiota was investigated using a next generation sequencing (NGS) technique. Firmicutes resulted significantly more abundant in the healthy dogs compared with the other two groups. Conversely, Proteobacteria were more abundant in symptomatic dogs. Even in rarest phyla comparison some significant differences were found, as well as in comparison at classes, order, family and genus levels. The symptomatic group had lower concentration of all the lymphocyte classes (CD5, CD21, CD4, CD8) compared to the other groups. A lower abundance of Firmicutes is reported in literature in diseased animals compared to the healthy ones and this is in agreement with the results of this study. Increased Proteobacteria in sick animals could suggest a dysbiosis status, even without distinct gastrointestinal signs. The leukocyte classes results indicate a decreased Th1 response in symptomatic dogs. Studies also investigating the cytokine response could deepen the knowledge on the pathogenesis of canine leishmaniasis.
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- 2022
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40. Novel type of atomic-scale spin lattice at a surface and its emergent Hall effect
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Hoffmann, M., Weischenberg, J., Dupe, B., Freimuth, F., Ferriani, P., Mokrousov, Y., and Heinze, S.
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We predict the occurrence of a novel type of atomic-scale spin lattice in an Fe monolayer on the Ir(001) surface. Based on density functional theory calculations we parametrize a spin Hamiltonian and solve it numerically using Monte-Carlo simulations. We find the stabilization of a three-dimensional spin structure arranged on a 3x3 lattice. Despite an almost vanishing total magnetization we predict the emergence of a large anomalous Hall effect, to which there is a significant topological contribution purely due to the real space spin texture at the surface., Comment: 5 pages
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- 2015
41. Disease activity index is associated with subclinical atherosclerosis in childhood-onset systemic lupus erythematosus
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Priscila B. S. Medeiros, Roberta G. Salomão, Sara R. Teixeira, Diane M. Rassi, Luciana Rodrigues, Davi C. Aragon, Priscila G. Fassini, Fábio V. Ued, Rita C. Tostes, Jacqueline P. Monteiro, Virgínia P. L. Ferriani, and Luciana M. de Carvalho
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Atherosclerosis ,Lupus Erythematosus, systemic, childhood ,Carotid intima-media thickness ,Nutritional assessment ,Pediatrics ,RJ1-570 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Systemic lupus erythematosus (SLE) is an independent risk factor for cardiovascular events. The present study determined the prevalence of subclinical atherosclerosis in childhood-onset SLE using the carotid intima-media thickness (CIMT) measurement and investigated associations between traditional and nontraditional risk factors for atherosclerosis, such as medications, SLE Disease Activity Index - SLEDAI-2 K and SLICC-ACR damage index and CIMT. Methods Cross-sectional prospective study between 2017 and 2018. CIMT was assessed by ultrasonography. Data were collected by chart review, nutritional evaluation and laboratory tests and analyzed by Fisher, Wilcoxon-Mann-Whitney tests, multiple linear and log binomial regression. Results Twenty-eight patients (mean age 13.9 years, SD 3) were enrolled. The prevalence of subclinical atherosclerosis was 32% (95% CI 14.8, 49.4). The mean CIMT was 0.43 ± 0.035 mm. The most common traditional risk factors observed were dyslipidemia (82.1%), uncontrolled hypertension (14.2%), obesity (14.3%), and poor diet (78.6%). Uncontrolled hypertension (p = 0.04), proteinuria (p = 0.02), estimated glomerular filtration rate 5 (P = 0.04) were associated with subclinical atherosclerosis. SLEDAI-2 K > 5 maintained association with CIMT after adjusting for control variables. Conclusion Subclinical atherosclerosis is frequently observed in cSLE, mainly in patients with moderate to severe disease activity.
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- 2021
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42. Downregulation of DROSHA: Could It Affect miRNA Biogenesis in Endometriotic Menstrual Blood Mesenchymal Stem Cells?
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Ana Clara Lagazzi Cressoni, Letícia B. C. Penariol, Cristiana Carolina Padovan, Maristela D. Orellana, Júlio Cesar Rosa-e-Silva, Omero Benedicto Poli-Neto, Rui Alberto Ferriani, Cláudia Cristina Paro de Paz, and Juliana Meola
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endometriosis ,DROSHA ,miRNA biosynthesis ,MenSC ,RT-qPCR ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Menstrual blood mesenchymal stem cells (MenSCs) have gained prominence in the endometriosis scientific community, given their multifunctional roles in regenerative medicine as a noninvasive source for future clinical applications. In addition, changes in post-transcriptional regulation via miRNAs have been explored in endometriotic MenSCs with a role in modulating proliferation, angiogenesis, differentiation, stemness, self-renewal, and the mesenchymal–epithelial transition process. In this sense, homeostasis of the miRNA biosynthesis pathway is essential for several cellular processes and is related to the self-renewal and differentiation of progenitor cells. However, no studies have investigated the miRNA biogenesis pathway in endometriotic MenSCs. In this study, we profiled the expression of eight central genes for the miRNA biosynthesis pathway under experimental conditions involving a two-dimensional culture of MenSCs obtained from healthy women (n = 10) and women with endometriosis (n = 10) using RT-qPCR and reported a two-fold decrease in DROSHA expression in the disease. In addition, miR-128-3p, miR-27a-3p, miR-27b-3p, miR-181a-5p, miR-181b-5p, miR-452-3p, miR-216a-5p, miR-216b-5p, and miR-93-5p, which have been associated with endometriosis, were identified through in silico analyses as negative regulators of DROSHA. Because DROSHA is essential for miRNA maturation, our findings may justify the identification of different profiles of miRNAs with DROSHA-dependent biogenesis in endometriosis.
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- 2023
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43. Tunnelling anisotropic magnetoresistance effect of single adatoms on a noncollinear magnetic surface
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Caffrey, Nuala M., Schröder, Silke, Ferriani, Paolo, and Heinze, Stefan
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Condensed Matter - Materials Science - Abstract
The tunnelling anisotropic magnetoresistance (TAMR) effect describes the sensitivity of spin-polarized electron transport to the orientation of the magnetization with respect to the crystallographic axes. As the TAMR effect requires only a single magnetic electrode, in contrast to the tunnelling magnetoresistance effect, it offers an attractive route towards alternative spintronics applications. In this work we consider the TAMR effect at the single-atom limit by investigating the anisotropy of the local density of states in the vacuum above transition-metal adatoms adsorbed on a noncollinear magnetic surface, the monolayer of Mn on W(110). This surface presents a cycloidal spin spiral ground state with an angle of 173$^\circ$ between neighbouring spins and thus allows a quasi-continuous exploration of the angular dependence of the TAMR of adsorbed adatoms using scanning tunnelling microscopy. Using first-principles calculations, we investigate the TAMR of Co, Rh and Ir adatoms on Mn/W(110) and relate our results to magnetization direction dependent changes in the local density of states. The anisotropic effect is found to be enhanced dramatically on the adsorption of heavy transition-metal atoms, with values of up to 50% predicted from our calculations. This effect will be measurable even with a non-magnetic STM tip., Comment: 17 pages, 8 figures
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- 2014
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44. Complex trend of magnetic order in Fe clusters on 4$d$ transition-metal surfaces
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Sessi, V., Otte, F., Krotzky, S., Tieg, C., Wasniowska, M., Ferriani, P., Heinze, S., Honolka, J., and Kern, K.
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Condensed Matter - Materials Science - Abstract
We demonstrate the occurrence of compensated spin configurations in Fe clusters and monolayers on Ru(0001) and Rh(111) by a combination of X-ray magnetic circular dichroism experiments and first-principles calculations. Our results reveal complex intra-cluster exchange interactions which depend strongly on the substrate 4$d$-band filling, the cluster geometry as well as lateral and vertical structural relaxations. The importance of substrate 4$d$-band filling manifests itself also in small nearest-neighbor exchange interactions in Fe dimers and in an nearly inverted trend of the Ruderman-Kittel-Kasuya-Yosida coupling constants for Fe adatoms on the Ru and Rh surface.
- Published
- 2014
45. Panniculitis in childhood-onset systemic lupus erythematosus: a multicentric cohort study
- Author
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Mônica Verdier, Pedro Anuardo, Natali Weniger Spelling Gormezano, Ricardo Romiti, Lucia Maria Arruda Campos, Nadia Emi Aikawa, Rosa Maria Rodrigues Pereira, Maria Teresa Terreri, Claudia Saad Magalhães, Juliana C. O. A. Ferreira, Marco Felipe Castro Silva, Mariana Ferriani, Ana Paula Sakamoto, Virginia Paes Leme Ferriani, Maraísa Centeville, Juliana Sato, Maria Carolina Santos, Eloisa Bonfá, and Clovis Artur Silva
- Subjects
Lupus erythematosus panniculits ,Childhood ,Systemic lupus erythematosus and multicenter study ,Diseases of the musculoskeletal system ,RC925-935 ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Objective To evaluate prevalence, clinical manifestations, laboratory abnormalities, treatment and outcome in a multicenter cohort of childhood-onset systemic lupus erythematosus (cSLE) patients with and without panniculitis. Methods Panniculitis was diagnosed due to painful subcutaneous nodules and/or plaques in deep dermis/subcutaneous tissues and lobular/mixed panniculitis with lymphocytic lobular inflammatory infiltrate in skin biopsy. Statistical analysis was performed using Bonferroni correction(p
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- 2019
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46. Cláusula de não concorrência na alienação de participação societária: exame de seus requisitos de validade e ineficácia superveniente
- Author
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Adriano Ferriani and Giovanni Nanni
- Subjects
cláusula de não concorrência ,aquisição de participação societária ,direito comercial ,direito civil ,código civil ,contrato ,ineficácia de negócio jurídico ,Law ,Civil law ,K623-968 - Abstract
Trata-se de extrato de parecer elaborado em disputa arbitral na qual se discutiu a validade de cláusula de não concorrência pactuada em contrato de aquisição de participação societária. São analisados os requisitos de validade de referida convenção, assim como a hipótese de sua ineficácia superveniente.
- Published
- 2020
47. Comparative Evaluation of Peripheral Blood Neutrophil to Lymphocyte Ratio, Serum Albumin to Globulin Ratio and Serum C-Reactive Protein to Albumin Ratio in Dogs with Inflammatory Protein-Losing Enteropathy and Healthy Dogs
- Author
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Federica Cagnasso, Antonio Borrelli, Enrico Bottero, Elena Benvenuti, Riccardo Ferriani, Veronica Marchetti, Piero Ruggiero, Barbara Bruno, Cristiana Maurella, and Paola Gianella
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dog ,chronic enteropathy ,inflammatory bowel disease ,leukocytes ,clinical response ,Veterinary medicine ,SF600-1100 ,Zoology ,QL1-991 - Abstract
Few routinely available biomarkers are clinically useful in assessing dogs with inflammatory protein-losing enteropathy caused by immunosuppressive-responsive enteropathy (IRE-PLE). Only the neutrophil to lymphocyte ratio (NLR) has been studied, while no information exists on the use of the albumin to globulin ratio (AGR) and C-reactive protein to albumin ratio (CRP/ALB). We aimed to evaluate the clinical significance of the NLR, AGR and CRP/ALB in a population of dogs with IRE-PLE. The medical records of 53 IRE-PLE dogs were reviewed at the time of diagnosis (T0) and 1 month after the initiation of immunosuppressants (T1). A control group of 68 healthy dogs was used for comparison. At T0, the median values of the NLR and AGR of sick dogs were significantly higher and lower than those of healthy dogs, respectively. With the increase in the chronic enteropathy activity index, AGR and CRP/ALB significantly decreased and increased, respectively. At T1, NLR and AGR significantly increased, while CRP/ALB significantly decreased. NLR, AGR and CRP/ALB did not differ significantly between dogs classified as responders and nonresponders according to the chronic enteropathy activity index. Further studies are needed to provide more information on this subject.
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- 2023
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48. Viability of a MSQOL-54 general health-related quality of life score using bifactor model
- Author
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Giordano, Andrea, Testa, Silvia, Bassi, Marta, Cilia, Sabina, Bertolotto, Antonio, Quartuccio, Maria Esmeralda, Pietrolongo, Erika, Falautano, Monica, Grobberio, Monica, Niccolai, Claudia, Allegri, Beatrice, Viterbo, Rosa Gemma, Confalonieri, Paolo, Giovannetti, Ambra Mara, Cocco, Eleonora, Grasso, Maria Grazia, Lugaresi, Alessandra, Ferriani, Elisa, Nocentini, Ugo, Zaffaroni, Mauro, De Livera, Alysha, Jelinek, George, Solari, Alessandra, and Rosato, Rosalba
- Published
- 2021
- Full Text
- View/download PDF
49. Disease activity index is associated with subclinical atherosclerosis in childhood-onset systemic lupus erythematosus
- Author
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Medeiros, Priscila B. S., Salomão, Roberta G., Teixeira, Sara R., Rassi, Diane M., Rodrigues, Luciana, Aragon, Davi C., Fassini, Priscila G., Ued, Fábio V., Tostes, Rita C., Monteiro, Jacqueline P., Ferriani, Virgínia P. L., and de Carvalho, Luciana M.
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- 2021
- Full Text
- View/download PDF
50. Identification of suitable reference genes for mesenchymal stem cells from menstrual blood of women with endometriosis
- Author
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Zucherato, Victoria S., Penariol, Leticia B. C., Silva, Lilian E. C. M., Padovan, Cristiana C., Poli-Neto, Omero B., Rosa-e-Silva, Julio C., Ferriani, Rui A., and Meola, Juliana
- Published
- 2021
- Full Text
- View/download PDF
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