138 results on '"P. Davous"'
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2. Posters
- Author
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Ryan, D. W., Belyaev S., Rudnov V., Mironov A., Bhagwanjee, S., Muckart, D. J. J., Hodgson, R. E., Afessa, B., Meyers, B., Koch, K., Delke, I., Schelline, G., Meier, M., Haller, M., Briegel, J., Schüffel, W., Peter, K., Jones, C., Griffiths, R. D., Macmillan, R. R., Harris, C., Colardyn, F. A., Dheene, P., Danneels, C., Verstraete, A., Burn, L., Dawsen, B., Baudouin, S. V., Stoll, C., Schelling, G., Bullinger, M., Stott, S. A., Noble, D. W., Weir, J., Vesely, H., Gregor, Th., Defouillov, C., Defouilloy, I., Dimov, G., Tinturier, F., Slama, M., Ossart, M., Rosengaard, L. Bredahl, Eriksen, K., Nielsen, P. Rotbøll, Heslet, L., Moreno, R., Miranda, D. Reis, Fidler, V., Apolone, G., Sicignano, A., Carozzi, C., Giudici, D., Merli, G., Pulici, M., Gaillard, M., Emmanuelli, J., Hervé, C., Davous, H., Beck, D. H., Taylor, B. L., Smith, G. B., Paionk, F. G., Waydhas, C., Fischer, A., Duswald, K. H., Jiménez, M. J., del Nogal, F., Martín, A., Díaz, R., López, J., Suárez, J., Algora, A., Singer, M., Groeneveld, A. B. J., Bossink, A. W. K., Hack, C. E., Thijs, L. G., Mata, G. Vazquez, Fernandez, R. Rivera, Paeec, Proyecto, Schulze, K., Verner, Lj., Logemann, F., Kirchner, E., Garnacho-Montero, J., García-Garmendia, J. L., Ortiz-Leyba, C., Rincón-Ferrari, M. D., Villar, J. Monterrubio, Jiménez-Jiménez, F. J., Jiménez-Jiménez, L. M., Armaganidis, A., Dimitriadou, E., Kaltsas, P., Charisis, A., Pontikis, X., Roussos, Ch., Platsouka, E., Routsi, Ch., Markaki, V., Paniara, O., Young, J. D., Newton, B., Rowan, K., Jara, F., Naya, J. M., Cherta, I., Quíntana, S., Vázquez, P., Alvarez, M., Perez, J. Martinez, Garcia-Bach, M., Aparicio, A., Vila, F., Rué, M., Valero, C., Quintana, S., Artigas, A., Linde-Zwirble, W. T., Clermont, G., Coleman, M. B., Brodak, S., Angus, D. C., Dougnac, A., Hernandez, G., Ojeda, M., Castro, J., Labarca, E., Castillo, L., Andresen, M., Bugedo, G., Diaz, O., Arriagada, D., Dagnino, J., Pinsky, M. R., Newbold, R. C., Tampubolon, O. E., Iskandar, S., Siahaan, M., Suntoro, A., Albert, A., Fongaro, A., Carlot, A., Sattin, A., ARCHIDIA, and ICNARC Working Group on coding conditions in intensive care
- Published
- 1996
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3. Le deuil, expérience de fraternité et d’altérité. Le groupe d’entraide, expérience d’appartenance
- Author
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Davous, D.
- Published
- 2005
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4. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain: Abstracts of Symposia and free communications
- Author
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Harms, L., Bock, A., JÄnisch, W., Valdueza, J., Weber, J., Link, I., De Keyser, J., Goossens, A., Wilczak, N., Vedeler, C., Bjorge, L., Uvestad, E., Conti, G., Williams, K., Ginsberg, L., Rafique, S., Rapoport, S. I., Gershfeld, N. L., De La Meilleure, G., Crevits, L., Faiss, J. H., Heye, N., Blanke, J., Sackmann, A., Kastrup, O., Doornbos, R., van der Worp, H. B., Kappelle, L. J., Bar, P. R., Davie, C. A., Barker, G. J., Brenton, D., Miller, D. H., Thompson, A. J., Block, F., Schwarz, M., Delodovici, L., Baruzzi, F., Bonaldi, G., Dario, A., Marra, A., Mercuri, A., Dworzak, F., Cavallari, P., Confalonieri, P., Zuffi, M., Antozzi, C., Cornelio, F., Baldissera, F., Chassande, B., Ameri, A., Eymard, B., Poisson, M., Vérier, A., Brunet, P., Congia, S., Murgia, P. L., Cannas, A., Borghero, G., Uselli, S., Mellino, G., Ferrai, R., Lampis, R., Massa, R., Muzzetto, B., Giannini, F., Rossi, S., Cioni, R., d'Aniello, C., Guarneri, A., Battistini, N., Ceriani, F., Del Santo, A., Poloni, M., Campo, J. F., Iglesias, F., Guitera, M. V., Farinas, C., Pascual, J., Leno, C., Berciano, J., Thorpe, I. W., Kendall, B. E., McDonald, W. I., Moulignier, A., Dromer, F., Baudrimont, M., Dupont, B., Gozlan, J., El Amrani, M., Petit, J. C., Roullet, E., Sterzi, R., Causaran, R., Protti, A., Riva, M., Erminio, F., Arena, O., Villa, F., Maccagnano, E., Miletta, M., Spinelli, F., Ben-Hur, T., Weidenfeldl, J., Rao, N. S., Chari, C. C., Laforet, P., Matheron, S., Adams, D., Chemouilli, Ph., Desi, M., Said, G., Davous, P., Lionnet, F., Pulik, M., Genet, P., Rozenberg, F., Cartier, L. M., Castillo, J. L., Cea, J. G., Villagra, R., de Saint Martin, L., Mahieux, F., Manifacier, M. J., Mattos, K., Queiros, C., Publio, L., Vinhas, V., PeÇanha-Martins, A. C., Melo, A., Liska, U., Zifko, U., Budka, H., Drlicek, M., Grisold, W., Kaufmann, R., Kaiser, R., Czygan, M., Gomes, I., Jones, N., Cunha, S., EmbiruÇu, E. Katiane, Vieira, V., Araujo, I., Alexandra, M., Ferreira, A., Goes, J., Chemouilli, P., Israel-Biet, Masson, H., Lacroix, C., Gasnault, J., Hildebrandt-Müller, B., Oschmann, P., Krack, P., Willems, W. R., Dorndorf, W., Freitas, V., Bittencourt, A., Fernandes, D., Nascimento, M. H., Severo, M., Moraes, D., Muller, M., Hasert, K., Merkelbach, S., Schimrigk, K., van Oosten, B. W., Lai, M., Polman, C. H., Bertelsmann, F. W., Hodgkinson, S., Cabre, P. H., Volpe, L., Smadja, D., Vernant, J. P., Villaroya, H., Violleau, K., Younes-Chennoufi, A. Ben, Baumann, N., Villanueva-Hemandez, P., Ballabriga, J., Basart, E., Arbizu, T. X., Perez-Serra, J., Vinuels, F., Giron, J. M., Castilla, J. M., Redondo, L., Izquierdo, G., Lauer, K., Henneberg, A., Bittmann, N., Link, D., Wollinsky, K. H., Mobner, R., Fassbender, K., Kuhnen, J., Schwartz, A., Hennerici, M., Miller, A., Lider, O., Abramsky, O., Weiner, H. L., Offner, H., Vanderbark, A. A., Paoino, E., Fainardi, E., Addonizio, M. C., Ruppi, P., Tola, M. R., Granieri, E., Carreras, M., Sazdovitch, V., Joutel, A., Verdier-taillefer, M. H., Heinzlef, O., Radder, C., Tournier-Lasserve, E., Brenner, R. E., Munro, P. M. G., Williams, S. C. R., Bell, J. D., Hawkins, C. P., Filippi, M., Campi, A., Dousset, V., Canal, N., Comi, G., Zhu, J., Weber, F., Retska, R., List, J., Zhang, L., Brock, M., Taphoorn, M. J. B., Heimans, J. J., van der Veen, E. A., Karim, A. B. M. F., Sarazin, M., Argentino, N., Delattre, J. Y., Derkinderen, P., Buchwald, B., Schroter, G., Serve, G., Franke, C. H., Conrad, B., Kitchen, N. D., Thomas, D. G. T., Forman, A. D., Ang, Kie- Kian, Price, R., Stephens, C., Salmaggi, A., Nermni, R., Silvani, A., Forno, M. G., Luksch, R., Boiardi, A., Grzelec, H., Fryze, C., Nowacki, P., Zdziarska, B., Sanson, M., Merel, P., Richard, S., Rouleau, G., Thomas, G., Olsen, N. K., Pfeiffer, P., Egund, N., Bentzen, S. M., Johannesen, L., Mondrup, K., Rose, C., Zyluk, B., Wondrusch, E., Berger, O., Fast, N., Jellinger, K., Lindner, K., Urman, A., Thibault, J. L., Duyckaerts, Ch., Strik, H., Muller, B., Richter, E., Krauseneck, P., Steinbrecher, A., Schabet, M., Hess, C., Bamberg, M., Dichgans, J., Counsell, C. E., McLeod, M., Grant, R., Creel, G. B., Claus, D., Sieber, E., Engelhardt, A., Rechlin, T., Thierauf, P., Neubauer, U., Peresson, M., Di Giovacchino, G., Romani, G. L., Di Silverio, F., Danek, A., Kuffner, M., Hoermann, R., Schopohl, J., Laska, M., Heye, B., Zangaladze, A. T., Valls-SoIè, J., Cammarota, A., Alvarez, R., Tolosa, E., Hallett, M., Ulbricht, D., Ganslandt, O., Kober, H., Vieth, J., Grummich, P., Pongratz, H., Brigel, C., Fahlbusch, R., Serra, F. P., Palma, V., Nolfe, G., Buscaino, G. A., Rothstein, T. L., Gibson J. M., Morrison P. M., Collins A. D., Eiselt, M., Wagnur, H., Zwiener, U., Schindler, T., Efendi, H., Ertekin, C., Erfas, M., Larsson, L. E., Sirin, H., AraÇ, N., Toygar, A., Demir, Y., Seddigh, S., Vogt, T. H., Hundemer, H., Visbeck, A., Pastena, L., Faralli, F., Mainardi, G., Gagliardi, R., Linden, D., Berlit, P., Lopez, O. L., Becker, J. T., Jungreis, C., Brenner, R., Rezek, D., Dekesky, S. T., Estol, C., Boller, F., Fernandez, J. M., Mederer, S., Batlle, J., Turon, A., Codina, A., Hitzenberger, P., Vila, N., Valls-SolÇ, J., Chamorro, A., Pouget, J., Schmied, A., Morin, D., Azulay, J. Ph., Vedel, J. P., Montalt, J., Escudero, J., Barona, R., Campos, A., Varli, K., Ertem, E., Uludag, B., Yagiz, A., Privorkin, Z., Steinvil, Y., Kott, E., Combarros, O., Sanchez-Pernaute, R., Orizaola, P., Mokrusch, Th., Kutluaye, E., Selcuki, D., Ertikin, C., Zettl, U., Gold, R., Harvey, G. K., Hartung, H. P., Toyka, K. V., Wokke, J. H. J., Oey, P. L., Ippel, P. F., Jansen, G. H., Franssen, H., Toyooka, K., Fujimura, H., Ueno, S., Yoshikawa, H., Yorifuji, S., Yanagihara, T., Talamon, C., Tzourio, C., Kiefer, R., Jung, S., Toyka, K., Ruolt, I., Tranchant, C., Mohr, M., Warter, J. M., Younger, D. S., Rosoklija, G., Hays, A. P., Kurita, R., Hasegawa, O., Matsumto, M., Komiyama, A., Nara, Y., Oueslati, S., Belal, S., Turki, I., Ben Hamida, C., Hentati, F., Ben Hamida, M., Kwiecinski, H., Krolicki, L., Domzal-Stryga, A., Dellemijn, P. L. I., van Deventer, P., van Moll, B., Drogendijk, T., Vecht, Ch. J., Nemni S., Amadio, Fazio, R., Galardin, G., Delodovici, M. L., Peghi, E., Monticelli, M. L., Sessa, A., Viguera, M. L., Palomar, M., Gamez, J., Cervera, C., Navarro, C., Serena, J., Duran, I., Fernandez, A. L., Comabella, M., Nos, C., Rio, J., Montalban, J., Navarro, X., Verdu, E., Darbra, S., Buti, M., Mrabet, A., Fredj, M., Gouider, R., Tounsi, H., Khalfallah, N., Haddad, A., Dbaiss, T., Ghnassia, R., Rouillet, E., Chedru, F., Porsche, H., Strenge, H., Li, S. W., Young, Y. P., Garcia, A. A., Baron, P., Scarpini, E., Bianchi, R., Conti, A., Livraghi, S., Rees, J. H., Gregson, N. A., Hughes, R. A. C., Sedano, M. J., Calleja, J., Canga, E., Bahou, Y., Biary, N., Al Deeb, S. M., Guern, E. L. E., Gugenheim, M., Tardieu, S., Aisonobe, T. M., Agid, Y., Bouche, P., Brice, A., Rautenstrauss, B., Nelis, E., Grehl, H., Van Broeckhoven, C., Pfeiffer, R. A., Liehr, T., Ganzmann, E., Gehring, C., Neundörfer, B., Geremia, L., Doronzo, R., Sacilotto, G., Sergi, P., Pastorino, G. C., Scarlato, G., Planté-Bordeneuve, V., Mantel, A., Baas, F., Moser, H., Antonini, A., Psylla, M., Günther, I., Vontobell, P., Beer, H. F., Leenders, K. L., Chaudhuri, K. Ray, Parker, J., Pye, I. F., Millac, P. A. H., Abbott, R. J., Sutter, M., Albani, C., de Rijk, M. C., Breteler, M. M. B., Graveland, G. A., van der Mechè, F. G. A., Hofman, A., Keipes, M., Hilger, Ch., Diederich, N., Metz, H., Hentges, F., Pollak, P., Benabid, A. L., Limousin, P., Hoffmann, D., Benazzouz, A., Perret, J., Laihinen, A., Rinne, J. O., Ruottinen, H., Nagren, K., Lehikoinen, P., Oikonen, V., Ruotsalainen, U., Rinne, U. K., Cocozza, S., Pizzuti, A., Cavalcanti, F., Monticelli, A., Pianese, L., Redolfi, E., Paiau, F., Di Donato, S., Pandolfo, M., Palau, F., Monros, E., De Michele, G., Smeyers, P., Lopez-ArLandis, J., Uilchez, J., Filla, A., Genis, D., Matilla, T., Volpini, V., Blanchs, M. I., Davalos, A., Molins, A., Rosell, J., Estivill, X., De Jonghe, P., Smeyers, G., Krols, L., Mercelis, R., Hazan, J., Weissenbach, J., Martin, J. J., Warner, T. A. T., Williams, L., Orb, A. S., Harding, A. E., Giunti, P., Sweeney, M. G., Spadaro, M., Jodice, C., Novelletto, A., Malaspina, P., Frontali, M., Salmon, E., Gregoire, Del Fiore, Comar, Franck, G., Scheltens, P. H., Siegfried, K., Dartigues, E., De Deyn, P., Horn, R., Nelson, I., Hanna, M. G., Morgan-Hughes, J. A., Collinge, J., Palmer, M. S., Campbell, T., Mahal, S., Sidle, K., Humphreys, C., Tavitian, B., Pappata, S., Jobert, A., Crouzel, A. M., DiGiamberardino, L., Steimetz, G., Barbanti, P., Fabbrini, G., Salvatore, M., Buzzi, M. G., Di Piero, V., Petraroli, R., Sbriccoli, A., Pocchiari, M., Macchi, G., Lenzi, G. L., Spiegel, R., Maguire, P., Schmid, W., Ott, A., Bots, M. L., Grobbe, D. E., Hofman, A., Howard, R. S., Russell, S., Losseff, N., Hirsch, N. P., Couderc, R., Bailleul, S., Nargeot, M. C., Touchon, J., Picot, M. C., Rizzo, M., Watson, G., McGehee, D., Dingus, T., Kappos, L., Radü, E. W., Haas, J., Hartard, C. H., Spuler, S., Yousry, T., Voltz, R., Scheller, A., Holler, E., Hohlfeld, R., Scolding, N. J., Sussman, J., Kolar, O. J., Farlow, M. R., Rice, P. H., Zipp, F., Sotgiu, S., Weiss, E. H., Wekerle, H., Chalmers, R., Robertson, N., Compston, D. A. S., Martino, G., Clementi, E., Brambilla, E., Moiola, L., Martinelli, V., Colombo, B., Poggi, A., Rovaris, M., Grimaldi, L. M. E., Roth, M. P., Descoins, P., Ballivet, S., Ruidavets, J. B., Waubant, E., Nogueira, L., Cambon-Thomsen, A., Clanet, M., Leppert, D., Hauser, S., Lugaresi, A., Tartaro, A., D'aurelio, P., Befalo, L. L. O., Thomas, A., Malatesta, G., Gambi, D., Benedikz, J. E. G., Magnusson, H., Poser, C. M., Guomundsson, G., Bates, T. E., Davies, S. E. C., Clark, J. B., Landon, D. N., ùther, J. R., Rautenberg, W., Overgaard, K., Sereghy, T., Pedersen, H., Boysen, G., Diez-Tejedor, E., Carceller, F., Gutierrez, M., Lopez-Pajares, R., Roda, J. M., Chandra, B., Ricart, W., Gonzalez-Huix, F., Molina, A., Rundek, T., Demarin, V., De Reuck, J., Boon, P., Decoq, D., Strijckmans, K., Goethals, P., Lemahieu, I., Nibbio, A., Chabriat, H., Vahedi, K., Nagy, T., Verin, M., Mas, J. L., Julien, J., Ducrocq, X., Iba-Zizen, M. T., Cabanis, E. A., Bousser, M. G., Rolland, Y., Landgraf, F., Bompais, B., Lemaitre, M. H., Edan, G., Vorstrup, S., Knudsen, L., Olsen, K. Skovgaard, Videbaek, C., Schroeder, T., van Gijn, J., Jansen, H. M. L., Pruim, J., Paans, A. M. J., Willemsen, A. T. M., Hew, J. M., vd Vliet, A. M., Haaxma, R., Vaalburg, W., Minderhoud, J. M., Korf, J., Soudain, S. E., Ho, T. W., Mishu, B., Li, C. Y., Nachainkin, I., Gao, C. Y., Cornblath, D. R., Griffin, J. W., Asbury, A. K., Blaser, M. J., McKhann, G. M., Ho, T., Macko, C., Xue, P., Stadlan, E. M., Ramos-Alvarez, M., Valenciano, L., Visser, L. H., van der Meché, F. G. A., van Darn, P. A., Meulstee, J., Schmitz, P. I. M., Jacobs, B., Oomes, P. G., Kleyweg, R. P., Jacobs, B. C., Endtz, H. P., van Doorn, P. A., van der Mech, F. G. A., Van den Berg, L. H., Mollee, I., Logtenberg, T., Thomas, P. K., Plant, G., Baxter, P. J., Luis, R. Santiago, Matsumoto, M., Notermans, N. C., Wokke, J. H. J., Lokhorst, H. M., van der Graaf, Y., Jennekens, F. G. I., Azulay, J. P., Bille-Turg, F., Valentin, P., Farnarier, G. G., Pellissier, J. F., Serratrice, G., Quasthoff, S., Schneider, U., Grafe, P., Hilkens, P. H. E., Moll, J. W. B., van der Burg, M. E. L., Planting, A. S. T., van Putten, W. L. J., van den Bent, M. J., Birklein, F., Spitzer, A., Lang, E., Neundorfer, B., Diehl, R. R., Lücke, D., Smith, G. D. P., Mathias, C. J., Serra, J., Campera, M., Ochoa, J. L., Ray Chaudhuri, K., Pavitt, D., Alam, M., Handwerker, H. O., Bleasdale-Barr, K., Smith, G., Murray, N. M. F., Hawkins, P., Pepys, M., Gellera, C., DiDonato, S., Taroni, F., Uncini, A., Di Muzio, A., Servidei, S., Silvestri, G., Lodi, R., Iotti, S., Barbiroli, B., Morrissey, S. P., Borruat, F. X., Francis, D., Mosely, I., Hansen, H. C., Helmke, K., Kunze, K., Sadzot, B., Maquet, P., Lemaire, Plenevaux, Damhaut, Sommer, C., Myers, R. R., Berta, E., Mantegazza, R., Argov, Z., Shapira, Y., Wirguin, I., Beuuer, J., Franke, C., Roberts, M., Willison, H., Vincent, A., Newsom-Davis, J., Morrison, K. E., Damels, R., Francis, M., Campbell, L., Davies, K. E., Kohler, W., Bucka, C., Hertel, G., Kanovsky, P., Auer, D., Ackermann, H., Klose, U., Naegele, Th., Bien, S., Voigt, K., Fink, G. R., Stephan, K. M., Wise, R. J. S., Mullatti, N., Hewer, L., Frackowiak, R. S. J., Weiller, C. S., Rijnites, M., Jueptner, M., Bauermann, T., Krams, M., Diener, H. C., van Walderveen, M. A. A., Barkhof, F., Hommes, O. R., Valk, J., Willmer, J. P., Guzman, D. A., Passingham, R. E., Silbersweig, D., Ceballos-Baumann, A., Frith, C. D., Frackowiak, R., Lucas, C. H., Goullard, L., Marchau, M. J., Godefroy, O., Rondepierre, P. H., Chamas, E., Mounier-Vehier, F., Leys, D., Renato, J., Verdugo, M. S. C., Campero, M., Jose, L., Ochoa, D. S. C., Vivancos, F., Tejedor, E. Diez, Martinez, N., Roda, J., Frank, A., Barreiro, P., Satoh, Y., Nagata, K., Maeda, T., Hirata, Y., YalÇinerner, B., Ozkara, C., Ozer, F., Ozer, S., Hanoglu, L., Zunker, P., Pozo, J. L., Oberwittler, C., Schick, A., Buschmann, H. -Ch., Ringelstein, E. Bernd, Lara, M., Anzola, G. P., Magoni, M., Volta, G. Dalla, Tarasov, A., Feigin, V., Beaudry, M. G., Carrier, S., Chicoutimi, Henriques, I. L., Bogoussslavsky, J., van Melle, G., Mathieu, J., Perusse, L., Allard, P., Prevost, C., Cantin, L., Bouchard, J. M., De Braekeleer, M., Agbo, C., Neau, J. P., Tantot, A. M., Dary-Auriol, M., Ingrand, P., Gil, R., Baltadjiev, D., Zekin, D., Sabey, K., Gennaula, C. P., Pope, B. A., Caparros-Lefebvre, D., Girard-Buttaz, I., Pruvo, J. P., Petit, H., Hipola, D., Martin, M., Giménez-Roldan, S., Ivanez, V., Japaridze, G., Carrasco, J. L., Picomell, I., Herranz, J. L., Macias, J. A., Nieto, M., Noya, M., Oller, L., Kiteva-Trencevska, G., Delgado, M. R., Liu, H., Luengo, A., Parra, J., Colas, J., Fernandez, M. J., Manzanares, R., Kornhuber, M. E., Malashkhia, V., Orkodashili, G., Martinez, M., Bonaventura, I., Porta, G., Martinez, I., Fernandez, A., Aguilar, M., Masnou, P., Drouet, A., Dreyfus, M., Cartron, J., Morel-Kopp, M. C., Tchernia, G., Kaplan, C., Lammers, M. W., Hekster, Y. A., Keyser, A., Meinardi, H., Renier, W. O., Boon, P. A. J. M., Have, M. D., Kint, B., Cruz, P., Cadilha, A., Almeida, R., Goncalves, M., Pimenta, M., Ramos, L. M. P., Polder, T. W., Broere, C. A., Polman, L., Rother, I., Rother, M., Schlaug, G., Arnold, S., Holthausen, H., Wunderlich, G., Ebner, A., Luders, H., Witte, O. W., Seitz, R. J., Serra, L. L., Gallicchio, B., Rotondi, F., Wieshmann, U., Meierkord, H., Sabev, K., Di Carlo, V., Gueguen, B., Derouesné, Ch., Ancri, D., Bourdel, M. C., Guillou, S., Aliaga, R., Chornet, M. A., Rodrigo, A., Pascual, A. Pascual -Leone, Catala, M. D., Pascual-Leone, A., Benbadis, S. R., Dinner, D. S., Chelune, G. J., Lüders, H. O., Piedmonte, M. R., Blanco, T., Lopez, M. P., Romero, B., Deltoro, A., Pascual, A., Pascual, Leone, Bolgert, F., Josse, M. O., Tassan, P., Touze, E., Laplane, D., Godenberg, F., Brizioli, E., Del Gobbo, M., Pelliccioni, G., Scarpino, O., Durak, H., Damlacik, G., Tunca, Z., Fidaner, H., Yurekli, Y., Yemez, B., Kaygisiz, A., Anllo, E. A., Esperet, E., Giovagnoli, A. R., Casazza, M., Spreafico, R., Avanzini, G., Mascheroni, S., Vecchio, I., Tornali, C., Antonuzzo, A., Grasso, A. A., Bella, R., Pennisi, G., Raffaele, R., Broeckx, J., Schildermans, F., Hospers, W., Deberdt, W., Carney, J. M., Aksenova, M., Chen, M. S., Juncadella, M., Busquets, N., De la Fuente, I., Rodriguez, A., Rubio, F., Soler, R., Khati, C., Pillon, B., Deweer, B., Malapani, C., Malichard, N., Dubois, B., Rancurel, G., Lopez, D. L., Jungreia, G., DeKosky, S. T., Boiler, F., Weiller, C., Rijntjes, M., Mueller, S. P., Maguire, E. A., Burke, E. T., Staunton, H., Phillips, J., Rousseaux, M., Pena, J., Bertran, I., Santacruz, P., Lopez, R., Catafau, A., Lomena, F., Blesa, R., Rampello, L., Nicoletti, A., Cabaret, M., Lesoin, F., Steinling, M., Tournev, I., Maier-Hauff, K., Schroeder, M., Wolf, A., Cochin, J. P., Noel, I., Augustin, P., Auzou, P., Hannequin, D., Maria, V., Lopez-Bresnahan, Danielle, D. M., Antin-Ozerkis B. A., Bartels, E., Rodiek, S. O., Flugel, K. A., Campos, D. M., Salas-Puig, J., Del Rio, J. Sanhez, Vidal, J. A., Lahoz, C. H., Eraksoy, M., Barlas, O., Barlas, M., Bayindir, C., Ozcan, H., Birbamer, G., Gerstenbrand, F., Felber, S., Luz, G., Aichner, F., Seidel, G., Kaps, M., Hutzelmann, A., Gerriets, T., Kruggel, F., Martin, P. J., Gaunt, M. E., Abbot, R. J., Naylor, A. R., Meary, E., Dilouya, A., Meder, J. F., De Recondo, J., Lebtahi, R., Neff, K. W., Meairs, S., Viola, S., Matta, E., Aquilone, L., Rise, I. R., Authier, F. J., Kondo, H., Ghnassia, R. T., Degos, J. D., Gherardi, R. K., Bardoni A., Ciafaloni E., Comi G. P., Bresolin N., Robotti M., Moggio M., Rigoletto C., Roses A., Scarlato G., Castelli, E., Turconi, A., Bresolin, N., Perani, D., Felisari, G., Chariot, P., de Pinieux, G., Astier, A., Jacotot, B., Gherardi, R., Fischer-Gagnepain, V., Louboutin, J. P., Crespo, F., Florea-Strat, A., Fromont, G., Sabourin, J. -C., Gonano, E. -F., Moroni, I., Prelle, A., Iannaccone, S., Quattrini, A., deRino, F., Sessa, M., Golzi, V., Smirne, S., Nemni, R., Turpin, J. C., Lucotte, G., Jacobs, S. C. J. M., Willems, P. W. A., Bootsma, A. L., Lasa, A., Calaf, M., Baiget, M., Gallano, B., Fichter-Gagnepain, V., Mazzucchelli, F., D'Angelo, M. G., Velicogna, M., Bet, L., Comi, G. P., Bordoni, A., Gonano, E. F., Bazzi, P., Rapuzzi, S., Moggio, M., Fagiolari, G., Ciscato, P., Messina, A., Battistel, A., Ryniewicz, B., Sangla, I., Desnuelle, C., Paquis, V., Cozzone, P. J., Bendahan, D., Sturenburg, H. J., Kohncke, G., Castellli, E., Linssen, W., Stegeman, D., Binkhorst, R., Notermans, S., Jaspert, A., Fahsold, R., de Munain, A. Lopez, Cobo, A., Martorell, L., Poza, J. J., Navarrete Palau, D., Emparanza, J. I., Sanchez-Roy, R., Vilchez, J. J., Hernandez, M., Tena, J. Garcia, Perla, C., Koutroumanidis, M., Papathanasopoulos, P., Papadimitriou, A., Papapetropoulos, T. H., Divari, R., Hadjigeorgiou, G. M., Anastasopoulos, I., Sansone, V., Rotondo, G., Meola, G., Rigoletto, C., Messina, S., Szwabowska-Orzeszko, E., Jozwiak, S., Michalowicz, R., Szaplyko, W., Petrella, M. A., Della Marca, G., Masullo, G., Mennuni, G. F., Kompf, D., Wascher, E., Verleger, R., Kaido, M., Soga, F., Toyooka, H., Bayon, C., Rubio, J., Carlomagno, S., Parlato, V., Santoro, A., Lavarone, A., Bonavita, V., Pentore, R., Venneri, A., Pasquier, F., Lebert, F., Grymonprez, L., Lefebvre, C., Van der Linden, M., Derouesné, C., Renault, B., Lacomblez, L., Homeyer, P., Ouss, L., Neuman, E., Malbezin, M., Barrandon, S., Guez, D., Stevens, M., van Swieten, J. C., Franke, C. L., Sanchez, A., Castellvirel, S., Mila, M., Jimenez, D., Pallesta, F., Ruiz, P. J. Garcia, Barrio, A., Barroso, T., Benitez, J., de Yebenes, J. Garcia, Manubens, J. M., Martinez-Lage, J. M., Larumbe, R., Muruzabal, J., Lacruz, F., Quesada, Pedro, Gallego, J., Ferini-Strambi, L., Marcone, A., Garancini, P., Tedesi, B., Jacob, B., Rozewicz, L., Langdon, D., Davie, C., Ron, M., Thompson, A., Koepp, M. J., Hansen, M. L., Guldin, B., Pressler, R. M., Ried, S., Scholz, C., Monaco, F., Gianelli, M., Schiavalla, M. P., Naldi, P., Cantello, R., Torta, R., Verze, L., Mutani, R., Knott, H., Ferbert, A., Schulze-Bonhage, A., Aust, W., Di Mascio, R., Marchioli, R., Vitullo, F., Di Pasquale, A., Sciulli, L., Kramer, V., Tognoni, G., Santacruz, P., Lopez, R., Marti, M. J., Charques, I., Catafau, A., Lomeila, F., Peila, J., Bertran, I., Blesa, R., Krendel, D. A., Costiga, D. A., Koeppen, S., Korn, W. M., Brugge, S., Schmitz, D., Scheulen, M. E., King, R. H. M., Robertson, A. M., Thomas, P. K., Kerkhofs, A., Vermersch, P., Dereeper, O., Daems Monpeun, C., Parent, M., Deplanque, D., Petit, H., Campero, M., Serra, J., Ochoa, J. L., Martinez-Matos, J. A., Montero, J., Olivé, M., Rene, R., Vidaller, A., Gugenheim, M., Gouider, R., Le Guern, E., Brice, A., Agid, Y., Bouche, P., Grisold, W., Ziflo, U., Drlicek, M., Budka, H., Jellinger, K., Zielinski, C. H., Ginsberg, L., King, R. H. M., Workman, J., Platts, A. D., Thomas, P. K., Gherardi, R. K., Florea-Strat, A., Poron, F., Sabourin, J. -C., Fazio, R., Nemni, R., Franceschi, M., Lorenzetti, I., Rinaldi, L., Canal, N., Weilbach, F. X., Sennlaub, A., Jung, S., Gold, R., Toyka, K. V., Hartung, H. P., Giegerich, G., Ellie, E., Vital, A., Steck, A. J., Vital, C., Julien, J., Doneda, P., Pizzul, S., Scarpini, E., Chiodi, P., Ramacci, M. T., Livraghi, S., Maimone, D., Annunziata, P., Salvadori, C., Guazzi, G. C., Arne-Bes, M. C., Delisle, M. B., Fabre, N., Hurtevent, J. F., Bes, A., Baudoin-Martin, D., Laborde, E., Viallet, F., Creisson, C., Crespi, V., Bogliun, G., Marzorati, L., Zincone, A., D'Angelo, L., Liberani, A., Merlini, M., Rivolta, R., Creange, A., Sabourin, J. -C., Theodorou, I., Gherardi, R. K., Conti, A. M., Malosio, M. L., Baron, P. L., Scarlato, G., Chorao, R., Rosas, M. J., Leite, I., Callea, L., Donati, E., Bargnani, C., Bud, M., Verdu, E., Navarro, X., Braun, S., Einius, S., Poindron, P., Warier, J. M., Bradley, J., Bekkelund, S. I., Torbergsen, T., Mellgren, S. I., Carlomagno, S., Parlato, V., Santoro, A., Lavarone, A., Boller, F., Bonavita, V., Engelhardt, A., Lörler, H., Robeck, S., Kluglein, C., Comi, G., Avoledo, V., Locatelli, T., Leocani, L., Galardi, G., Magnani, G., Medaglini, S., Chkhikvishvili, T. S., Zangaladze, A., Bratoeva, M., Kovachev, P., Chavdarov, D., Artemis, N., Karacostas, D., Milonas, I., Arpa, J., Lopez-Pajares, R., Cruz-Matinez, A., Sarria, J., Palomo, F., Alonso, M., Rodriguez-Al-barino, A., Lacasa, T., Nos, J., Barreiro, P., Martinez, A. Cruz, Villoslada, C., Alons, M., Taghavy, A., Hamer, H., Kratzer, A., Dethy, S., Pauwels, T., Monclus, M., Luxen, A., Goldman, S., Ziegler, M., Crambes, O., Ragueneau, I., Arnaud, F., Zappia, M., Montesanti, R., Colao, R., Palmieri, A., Branca, D., Nicoletti, G., Rizzo, M., Parlato, G., Quattrone, A., Vanacore, N., Zuchegna, P., Bonifati, V., Meco, G., Scholz, J., Friedrich, H. -J., Rohl, A., Ulm, G., Vieregge, P., Savettieri, G., Rocca, W. A., Meneghini, F., Grigoletto, F., Morgante, L., Reggio, A., Salemi, G., Di Pierri, R., OzckmekÇi, S., Ertan, S., Yeni, N., Apaydin, H., Erkol, G., Kiziltan, G., Denktas, F., Ranoux, D., de Recondo, J., Ostergaard, L., Werdelin, L., Odin, P., Lindvall, O., Dupont, E., Christensen, P. B., Boisen, E., Jensen, N. B., Schmiegelow, M., Ingwersen, S. H., Matias-Guiu, J., Canet, T., Falip, R., Martin, R., Galiano, L., Voloshin, M. Y., Burchinskaya, L. F., Cabrera-Valdivia, F., Jimenez-Jimenez, F. J., Molina, J. A., Fernandez-Calle, P., Vazquez, A., Canizares-Liebana, F., Larumbe-Lobalde, S., Ayuso-Peralta, L., Rabasa, M., Codoceo, R., Arrieta, F. J., Aguilar, M. V., Jorge-Santamaria, A., Martinez-Para, M. C., Alarcon, J., Mateo, D., Gimenez-Roldan, S., Gencheva, E., Tzonev, T. z., Georgiev, G., Petkova, P., Gasparini, M., Vanacore, N., Meco, N. G., de la Sierra, G., Aguado, F., Revilla, M., Varela, L., Rico, H., Feve, A., N'Guyen, J. P., Bathien, N., Fenelon, G., Veroust, J., Cesaro, P., Egersbach, G., Hattig, H., Schelosky, L., Wissel, J., Poewe, W., Durif, F., Albuisson, E., Debilly, B., Tournilhac, M., Magnani, C., Mocellini, C., Soffietti, R., Schiffer, D., Cardozo, A., Cruz-Sanchez, F. F., Falip, L., Potagas, G., Ziegler, M., Rondot, P., Bonifati, V., Fabrizio, E., Meco, G., Bostantjopoulou, S., Katsarou, Z., Kyriazis, G., Baas, H., Demisch, L., Esser, A., Zoeller, F., Burklin, F., Harder, S., Fischer, P. A., Arcusa, M. J., Hermandez, S., Claramonte, F. J., Pascual, A. Pascual- Leone, Alonso, M. D., Catata, M. D., Alessandri, A., Giustini, P., Dufour, A., Ciusani, E., Nespolo, A., Roelcke U., Radu E. W., von Ammon K., Maguire R. P., Leenders K. L., Radionova, M., Chavdarov, D., Bratoeva, M., Tzekov, Ch., Pietrangeli, A., Bove, L., Pace, A., Falqui, L., Jandolo, B., Potemkowski, A., Muller B., Reinhard I., Krone A., Warmuth M., Brocker E. M., Krauseneck P., Meyding-Lamadé, U., Krieger, D., Sartor, K., Hacke, W., Maugard-Louboutin, C., Fayet, G., Sagan, C., Martin, S., Ménégalli, D., Lajat, Y., Resche, F., Koriech, O. M., Al Moutaery, K., Yaqub, B., Jochens, R., Wolters, A., Venz, S., Cordes, M., Hecht, B. K., Chatel, M., Gaudray, P., Turc-Carel, C., Gioanni, J., Ayraud, N., Hecht, F., Rumbach, L., Racadot, E., Bataillard, M., Billot, M., Pariset, J., Wijdenes, J., Montalban, Rio J., Tintoré, M., Galan, I., Acarin, N., Rapaport, S., Huberman, M., Shechtcr, D., Karabudak, R., Kilinc, M., Boyacigil, S., Cila, A., Polo, J. M., Setien, S., Sanchez, R., Figols, J., Zubimendi, A., Nadareishvili, Z. G., Massot, R., Marés, R., Gallecho, F., Richart, C., Hernandez, M. A., Garcia, M. R., Lorenzo, J. N., Leon, C., Muros, M., Togores, J., Kutluk, K., Damlacik, G. A., Tekinsoy, B., Obuz, O., Baklan, B., Idiman, E., Genc, K., Zielasek, J., Schmidt, B., Liew, F. Y., Gulay, Z., Yulug, N., Wong, K. S., Wong, T. W., Yu, T. S., Kay, R., Poupon, R., Giral, P., Roberti, C., Zanette, E. M., Chiarotti, F., Brusa, L., Cerbo, R., Prusinski, A., Pondal, M., Canton, R., Dominigo, Erodriguez J., Pereira Monteino J. M., Pereira Monteino X., Pardo, J., Carroacedo, A., Barros, F., Lema, M., Castillo, J., Melchor, A., Montiel, I., Guiu, J. Matias, Kloss, T. M., Keidel, M., Jacob, M., Idiman, F., Idman, E., Ozturk, V., Metin, E., Yilmaz, M., Gerard, J. M., Bouton, R., Decamps, D., Herbaut, A. G., Delecluse, F., Cavenaile, M., Divano, L., Chazot, G., Boureau, F., Emile, J., Bertin, L., d'Allens, H., Ferro, J. M., Costa, I., Carletto, F., Catarci, T., Padovani, A., Iandolo, B., Bartoli, M., Bonamini, M., Pulcinelli, F., Pignatelli, P., Russo, M., Gazzaniga, P. P., Barros, J., Pinheiro, J., Correia, A. P., Monteiro, J. M. Pereira, Alvarez-Cermeno, J. C., Avello, G., Sastre, J. L., Vecino, A., Cesar, J. M., Leone, M., Stankov, B., D'Amico, D., Maltempo, C., Moschian, F., Fraschini, F., Bussone, G., Molto, J. M., Fernandez, E., Fernandez, A. Morento, Barreiro, A., Siclia, J., Castejon, P., Mihout, B., Malberin, M., Salzman, V., Bogousslavsky, J., Meneghetti, G., Baracchini, C., Bozzato, G., Marini, B., Mendel, T., Czlonkowska, A., Pasierski, T., Szwed, H., Marta-Moreno, J., Lopez-Delval, J., Mostacero, E., Morales, F., Mahagne, M. H., Rogopoulos, A., Bertrand, F., Bedoucha, P., Lanteri-Minet, M., Riva, D., Zorzi, C., Milani, N., Vajsar, J., Ronen, G., Macgregor, D., Becker, L., Susseve, J., Seidl, Z., Faber, J., Obenberger, J., Springer, R., Bax, R. T., Eckardt, T., Czettritz, G. V., Emmrich, P., Vlaski-Jekic, S., Petrova, V., Cherninkova, S., Gudeva, T., Tzekov, C., Devoti, M., Franceschetti, S., Mientus, S., Vienna, P., Vashtang, Y., Tazir, M., Assami, S., Oulbani, D., Kaci Ahmed, M. Ait, Andersen, G., Vestergaard, K., Riis, J. O., Chavdarov, D., Corbo, M., Previtali, S., Allen, R. R., McKay, W. C., Rowbotham, M. C., Castellvi-Pel, S., Banchs, I., Kruyer, H., Corral, J., Saugeir-Veber, P., Munnich, A., Bonneau, D., Rozet, J. M., Le Merrer, M., Boespflug-Tanguy, O., Gokyigit, A., Oktem, O., Demir, G., Caliskan, A., Gardiner, R. M., Shorvon, Simon, Wieser, Heinz -Gregor, Hossmann, K. A., Steinberg, A., van Crevel, H., Ducros, A., Labauge, P., Pinsard, N., Ponsot, G., Gouttiere, F., Gastaut, J. L., Delrieu, O., BesanÇon, V., Klopstock, T., May, A., Seibel, P., Papagiannuli, E., Reichmann, H., Gurses, C., Aykut, C., Aktan, S., De Vuono, G., Fiacco, F., Gazzaniga Pozzill, P. P., Assuerus, V., Jacomet, C., Picard, O., Rozenbaum, W., Nueckel, M., Osschmann, P., Horning, C. R., Caldarelli-Stefano, R., Omodeo-Zorini, E., Rivolta, G. E., Maserati, R., Cagni, A., Ferrante, P., Lamadé, W., Heb, Th., Gosztonyl, G., Daral, G., Fresquet, C., Storch-Hagenlocher, B., Wildemann, B., Jager, G., Fuhry, L., Van Paesschen, W., Grunewald, R. A., Duncan, J. S., Connelly, A., Jackson, G. D., Sisodiya, S., Raymond, A. A., Shorvon, S. D., Fish, D. R., Stevens, J. M., Savic, I., Pauli, S., Thorell, J. O., Browne, R. H., Kornhuber, J., Retz, W., Riederer, P., Boon, F., Calliauw, L., Hoksergen, I., Thiery, E., Caemert, J., Decoo, D., Desomer, A., Chevalier, Y., Grinspan, A., Hirsch, E., Moszkowski, J., Marescaux, C., Yaqub, B. A., Valdueza, J. M., Puchner, M. J. A., Dammann, O., Vortmeyer, A., Herrmann, H. -D., Peterson, W., Prevett, M. C., Cunningham, V., Brooks, D. J., Pomes, A., Sunol, C., Durwen, H. F., Confavreux, Ch., Grimaud, J., Saddier, P., Moreau, T., Cortinovis-Tourniaire, P., Aimard, G., Adeleine, P., Paty, D. W., Wiles, C. M., Midgard, R., Riise, T., Kvale, G., Nyland, H., Stodal, H., Haase, A., Lassmann, H., Deeb, S. M. Al., Bruyn, G. W., Semana, G., Teisserenc, H., Alizadeh, M., Loiseau, P., Birebent, B., Yaouanq, J., Genetet, B., Sabouraud, O., Charron, D. J., Shaw, C. 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- Published
- 1994
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5. Senile dementia of the Alzheimer type: is there a correlation between entorhinal cortex and dentate gyrus lesions?
- Author
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Senut, M. C., Roudier, M., Davous, P., Fallet-Bianco, C., and Lamour, Y.
- Published
- 1991
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- View/download PDF
6. Déficience intellectuelle et cancer chez l’enfant : analyse des pratiques concernant le choix du traitement
- Author
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Dangles, Marie-Thérèse, Davous, Dominique, Vialle, Guénola, Auvrignon, Anne, Angellier, Elisabeth, and Bourdeaut, Franck
- Abstract
Les décisions concernant les traitements d’un cancer survenant chez un enfant atteint de déficience intellectuelle sont complexes, en raison des séquelles souvent préoccupantes dans cette population particulièrement vulnérable. Pour éclairer ces difficultés, nous avons mené une enquête analysant les modalités de décision concernant le traitement d’enfants présentant une déficience intellectuelle et atteints de cancer, dans les centres d’onco-hématologie pédiatrique français.
- Published
- 2021
- Full Text
- View/download PDF
7. Les internes de pédiatrie et la mort de l’enfant
- Author
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Davous, Dominique and Petit, Arnaud
- Published
- 2022
- Full Text
- View/download PDF
8. Tremblement postural et ataxie révélant une prémutation X fragile ou syndrome FXTAS
- Author
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R. Juntas Morales, P. Davous, E. Bertolle, and C. Dupel-Pottier
- Subjects
Pediatrics ,medicine.medical_specialty ,Ataxia ,Neurological disorder ,Postural tremor ,medicine.disease ,Central nervous system disease ,White matter ,Fragile X syndrome ,medicine.anatomical_structure ,Atrophy ,Neurology ,medicine ,Cerebellar atrophy ,Neurology (clinical) ,medicine.symptom ,Psychology ,Neuroscience - Abstract
We report a case of FXTAS in a 58-year-old man who presented with postural tremor, mild ataxia and dysexecutive cognitive signs. The syndrome had a slow progressive course. Brain imaging by MRI showed characteristic abnormalities with mild cerebellar atrophy, symmetric high signals in the middle cerebellar peduncles and in the subcortical white matter of cerebral hemispheres. The diagnosis was confirmed by molecular genetics showing by southern blot a 100-120 expansion repeat of the CGG trinucleotide. FXTAS is a recently described syndrome, still unknown by most neurologists and probably rather frequent in men older than 60. We emphasize the value of clinical evaluation and brain imaging by MRI in some patients presenting with non specific motor or cognitive symptoms. A diagnosis of FXTAS may have implications for genetic counselling of female relatives.
- Published
- 2007
- Full Text
- View/download PDF
9. Morbo di Alzheimer
- Author
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P Davous, D Campion, and A Delacourte
- Subjects
Philosophy ,Humanities - Abstract
Il morbo di Alzheimer (MA) e una patologia neurodegenerativa che distrugge progressivamente e in modo irreversibile l’insieme delle funzioni intellettive. Si possono distinguere tre grandi fasi nella conoscenza e nel nostro approccio a questa patologia, la cui prevalenza e l’incidenza aumentano in modo esponenziale con l’eta: la prima fase, da Alzheimer fino agli anni Ottanta, e il periodo descrittivo che dimostra che le forme a esordio precoce e a esordio tardivo sono caratterizzate da due tipi di lesioni cerebrali: le placche amiloidi extracellulari e la degenerazione neurofibrillare (DNF) intraneuronale. La seconda fase, che va dal 1984 al 2004, e quella analitica, che mette in evidenza che la proteina amyloid protein precursor (APP) gioca un ruolo eziologico fondamentale. In effetti, le mutazioni genetiche delle forme familiari legate alle proteine APP, PS1 o PS2, cosi come le forme sporadiche associate all’allele E4 dell’apolipoproteina E, hanno in comune il fatto di aumentare il frammento catabolico Ab 42 che forma le placche amiloidi. Peraltro, e dimostrato che la DNF e costituita dall’aggregazione di una proteina citoscheletrica, la proteina tau. L’estensione corticale del processo di aggregazione di tau, chiamato «taupatia», corrisponde perfettamente all’espressione clinica del MA, che associa amnesia ippocampale, afasia che interessa la corteccia temporale, aprassia e agnosia che interessano le regioni polimodali associative. Questo periodo e caratterizzato dalla definizione di criteri diagnostici rigorosi, dallo sviluppo di tecniche di imaging morfologico e metabolico, di marcatori di laboratorio, dalla comparsa di terapie sintomatiche che tendono a una migliore regolazione dei livelli di acetilcolina e di glutammato. Parallelamente, la convergenza dei dati epidemiologici nei paesi sviluppati permette di realizzare l’importanza del peso socioeconomico del MA e delle sindromi affini: 850 000 casi nel 2006, circa 200 000 nuovi casi ogni anno. Questa presa di coscienza da parte di tutte le figure sanitarie si palesa con misure di carattere finanziario e sociale di accompagnamento e con l’implementazione di reti assistenziali. L’ultima tappa, appena iniziata, corrisponde a una nuova era, fatta di diagnosi precoce associata al concetto di mild cognitive impairment (MCI) e di studi terapeutici di consenso secondo cui APP e tau sono i due bersagli terapeutici piu appropriati.
- Published
- 2007
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10. Maladie d'Alzheimer
- Author
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P Davous, D Campion, and A Delacourte
- Subjects
medicine.medical_specialty ,business.industry ,Medicine ,business ,Dermatology - Published
- 2007
- Full Text
- View/download PDF
11. Diplégie faciale au cours d’une neuropathie démyélinisante inflammatoire aiguë secondaire à une varicelle
- Author
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R. Juntas Morales, J.-N. Tillier, and P. Davous
- Subjects
Neurology ,Neurology (clinical) - Abstract
Resume Introduction La primo-infection par le virus herpes zoster est responsable de nombreuses complications neurologiques dont de rares cas de paralysie faciale bilaterale. Observation Nous rapportons le cas d’une femme âgee de 38 ans qui developpa une diplegie faciale bilaterale d’installation subaigue accompagnee de paresthesies au niveau des membres quelques jours apres une primo-infection par varicelle. Parmi les examens complementaires, il existait une hyperproteinorachie et l’EMG montrait la presence d’une polyneuropathie demyelinisante. Le diagnostic evoque etait celui d’un syndrome de Guillain-Barre et un traitement par immunoglubulines intraveineuses fut realise avec amelioration progressive des symptomes. Conclusion L’immunotherapie est une attitude possible face aux atteintes neurologiques postvaricelles ou le mecanisme auto-immun parait le plus probable.
- Published
- 2009
- Full Text
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12. Visuo-spatial dysgnosia and Balint's syndrome as major symptoms of probable Alzheimer's disease
- Author
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F. Boiler, M. Agostini, M. Panisset, and P. Davous
- Subjects
Pediatrics ,medicine.medical_specialty ,genetic structures ,business.industry ,Visual form ,Posterior cortical atrophy ,Disease ,medicine.disease ,Apraxia ,Bálint's syndrome ,Neurology ,Severe dementia ,medicine ,Right posterior ,Dementia ,Neurology (clinical) ,business ,Neuroscience - Abstract
We describe three patients, respectively 57-, 54- and 55-years-old at onset of the disease, who developed over many years a progressive cortical visual dysfunction without overt dementia. At onset, the visual symptoms were mainly a visuo-spatial dysgnosia, but they progressively worsened to a near complete Balint syndrome in the three cases. In all of them, memory and language were only mildly affected during the first years of evolution, but a constructive and/or dressing apraxia and an optic ataxia in the left visual hemifield suggested in two cases a predominant dysfunction in the right hemisphere. Imaging of the brain by CT scan and MRI showed no focal atrophy, but the metabolic SPECT was early abnormal in all three cases showing a right posterior metabolic defect in two cases and a bilateral posterior hypometabolism in one case. Follow-up of the patients showed that they all developed language and memory disturbances leading to severe dementia after 5–8 years of evolution. It is suggested that these patients are affected by a visual form of Alzheimer's disease which is probably the most frequent cause of progressive Balint-Holmes syndrome.
- Published
- 1996
- Full Text
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13. A prospective study of depression in French patients with Parkinson's disease. The Depar study
- Author
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Sylvain Grignon, P. Davous, H.C. Neukirch, and P. Auquier
- Subjects
medicine.medical_specialty ,education.field_of_study ,Parkinson's disease ,Neurology ,business.industry ,Population ,Disease ,medicine.disease ,Mood ,Internal medicine ,medicine ,Physical therapy ,Neurology (clinical) ,Risk factor ,education ,business ,Prospective cohort study ,Depression (differential diagnoses) - Abstract
To investigate the prevalence and symptomatology of depression in Parkinson's disease (PD), we have studied 506 unselected patients attending the neurology services in French general hospitals during a 5 month period defined for prospective inclusion. 246 patients (48.6%) were suspected of depression according to different methods of evaluation and 168 (33.2%) were defined as definite or probable depression. According to the Montgomery and Asberg scale, 46 cases (9%) had a severity score suggestive of major depression. As a function of the cut-off score defined for severity, these patients represented from 23.2 to 43.7% of the depressive population with PD. There was no significant difference between depressed and non depressed PD patients as a function of the patient's current age or age at onset of PD. A significantly higher rate of depression was found among women with PD. A past history of depression was a risk factor for mood disorder after onset of PD. The severely depressed patients had a significantly longer duration of PD and a higher score of cognitive impairment than mildly or moderately depressed and non depressed patients with PD. Depressed patients had a significantly more advanced stage of disability than non-depressed patients with PD.
- Published
- 1995
- Full Text
- View/download PDF
14. [Facial diplegia and acute inflammatory demyelinating neuropathy secondary to varicella]
- Author
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R, Juntas Morales, J-N, Tillier, and P, Davous
- Subjects
Adult ,Chickenpox ,Electrodiagnosis ,Facial Paralysis ,Neural Conduction ,Humans ,Immunoglobulins, Intravenous ,Female ,Paresthesia ,Guillain-Barre Syndrome ,Demyelinating Diseases - Abstract
Primo-infection by varicella-zoster virus (VZV) may be associated with several neurologic complications. Bilateral facial palsy is a rather uncommon manifestation.We report the case of a 38-year-old woman who developed bilateral facial diplegia and paresthesia affecting all four limbs with subacute onset several days after varicella virus primoinfection. Ancillary tests showed hyperproteinorachia and signs of demyelinating polyneuropathy in nerve conduction tests. The diagnosis of Guillain-Barré syndrome was retained and a treatment with intravenous immunoglobulines was started, leading to progressive improvement.Immunotherapy is a possible therapeutic approach in the context of neurologic postinfectious complications after VZV infection where an underlying mechanism is probable.
- Published
- 2008
15. [Fragile X premutation presenting as postural tremor and ataxia (FXTAS syndrome)]
- Author
-
P, Davous, R, Juntas Morales, C, Dupel-Pottier, and E, Bertolle
- Subjects
Male ,Tegmentum Mesencephali ,Posture ,Brain ,Electroencephalography ,Middle Aged ,Magnetic Resonance Imaging ,Pedigree ,Blotting, Southern ,Cerebellum ,Fragile X Syndrome ,Tremor ,Humans ,Ataxia ,Atrophy ,Cognition Disorders ,Brain Stem - Abstract
We report a case of FXTAS in a 58-year-old man who presented with postural tremor, mild ataxia and dysexecutive cognitive signs. The syndrome had a slow progressive course. Brain imaging by MRI showed characteristic abnormalities with mild cerebellar atrophy, symmetric high signals in the middle cerebellar peduncles and in the subcortical white matter of cerebral hemispheres. The diagnosis was confirmed by molecular genetics showing by southern blot a 100-120 expansion repeat of the CGG trinucleotide. FXTAS is a recently described syndrome, still unknown by most neurologists and probably rather frequent in men older than 60. We emphasize the value of clinical evaluation and brain imaging by MRI in some patients presenting with non specific motor or cognitive symptoms. A diagnosis of FXTAS may have implications for genetic counselling of female relatives.
- Published
- 2007
16. Parents’ and children’s comprehension and decision in a paediatric early phase oncology trial: a prospective study
- Author
-
Béranger, Agathe, Bouazza, Nai¨m, de Haut de Sigy, Amélie, Foubert-Wenc, Anne-Charlotte, Davous, Dominique, Aerts, Isabelle, Geoerger, Birgit, Auvrignon, Anne, Brethon, Benoît, Leblond, Pierre, Corradini, Nadège, André, Nicolas, Martinez, Hélène, Dupont, Jean-Claude K, Doz, Francois, and Chappuy, Hélène
- Abstract
ObjectiveTo analyse parents’ and children’s understanding of consent information and assess their decision-making process in paediatric oncology.DesignProspective observational study.SettingsEleven French paediatric oncology units.PatientsParents and children who have been asked to give consent for participation in an early phase trial.InterventionsThirty-seven children and 119 parents were questioned using an audio-recorded semistructured interview.Main outcome measuresThe participants’ understanding of nine elements of the informed consent was assessed by comparing their answers with the informed consent leaflet. Their decision-making process was also evaluated.ResultsMost parents and children had an excellent understanding regarding their participation in a clinical trial (respectively 88.2% and 48.6%), the right to withdraw (76.5% and 43.2%) and the prospects of collective benefits (74.8% and 48.6%). By contrast, less than half of the parents and few of the children correctly understood the alternatives (respectively 47.5% and 27%), the risks related to participation (44.5% and 10.8%), the prospects of individual benefits (33.6% and 10.8%) and the purpose of the clinical trial (12.6% and 2.7%). Twenty-six (70.3%) children participated in the decision-making process. Most parents and children felt they had no choice but to participate in the trial to have access to a new anticancer treatment.ConclusionsWhat might appear to be a poor understanding of the research protocol may actually correspond to the families’ interpretation of the situation as a coping mechanism. All children (except infants) should get age-tailored information in order for them to have a meaningful involvement in research.
- Published
- 2019
- Full Text
- View/download PDF
17. [Apolipoprotein E and bleomycin hydrolase. Polymorphisms: association with neurodegenerative diseases]
- Author
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V, Nivet-Antoine, M-P, Coulhon, C, Le Denmat, B, Hamon, X, Dulcire, M, Lefebvre, F, Piette, P, Davous, D, Durand, and D, Duchassaing
- Subjects
Aged, 80 and over ,Cysteine Endopeptidases ,Apolipoproteins E ,Polymorphism, Genetic ,Base Sequence ,Genotype ,Alzheimer Disease ,Humans ,Reproducibility of Results ,Neurodegenerative Diseases ,Polymerase Chain Reaction ,Aged ,DNA Primers - Abstract
Several studies indicate a possible association between different genes and chronic neurodegenerative diseases including Alzheimer's disease (DTA). To further investigate, we have analyzed association between the apolipoprotein E (apo E) and bleomycin hydrolase (BH) polymorphisms and three groups of elderly patients: control subjects (T) (n = 68), late-onset sporadic DTA patients (DTAst) (n = 65) and other non vascular neurodegerative diseases (MNDA) (n = 52). Apo E-epsilon4 and BH-G alleles frequencies (%) are: 8.2 (T), 31.5 (DTAst), 16.4 (MNDA) and 41.4 (T), 35.6 (DTAst). No association has been observed between carrying the G allele and DTA in epsilon4 negative subjects but, our data have confirmed the earlier reports: carrying the epsilon4 allele is a dose-dependent risk factor for the DTAst (OR: 6.0, IC 95 %: 2.6-13.7) and decrease the age of symptom onset (p0.005). They have also suggested that apo E genotyping may be of interest to perform differential diagnosis of neurodegenerative diseases in elderly subjects.
- Published
- 2003
18. [Atypical CADASIL phenotypes and pathological findings in two new French families]
- Author
-
J, Mikol, D, Hénin, M, Baudrimont, A, Gaulier, D, Bacri, J N, Tillier, and P, Davous
- Subjects
Male ,Biopsy ,DNA Mutational Analysis ,Pseudobulbar Palsy ,Leukoencephalopathy, Progressive Multifocal ,Brain ,Receptors, Cell Surface ,Middle Aged ,Muscle, Smooth, Vascular ,Pedigree ,Diagnosis, Differential ,Dementia, Multi-Infarct ,Phenotype ,Proto-Oncogene Proteins ,Humans ,Female ,Aged ,Follow-Up Studies ,Skin - Abstract
Atypical phenotypes of CADASIL and corresponding anatomical data in two cases are described in 6 members of 2 new French families. In the first family, 4 cases in the same kindred were probably affected, two of them with a predominant psychiatric presentation, two others with dementia and a pseudo-bulbar syndrome of progressive evolution. No history of migraine or ischemic event were documented in any. In the propositus, the diagnosis was documented by skin biopsy, Notch 3 gene mutation and autopsy after the patient had died when 67 years old, 8 years after onset. Brain examination showed a widespread leukoencephalopathy with subcortical infarcts. Characteristic granular lesions of the small arteries of the brain and other organs were observed. In the second family, two cases are reported. One patient died when 63 years old after a subacute evolution mimicking intracranial hypertension. The anatomical diagnosis was retrospectively proven typical of CADASIL with Notch 3 immunostaining of arterial smooth muscle cells. The other case had a progressive evolution over 20 years of limb paresthesia with a mild spasticity diagnosed as a progressive form of multiple sclerosis. It was followed by a pseudo-bulbar syndrome and a mild subcortical dementia without acute ischemic attack. The diagnosis was confirmed by skin biopsy and mutation of the Notch 3 gene. This report illustrates
- Published
- 2001
19. [Tuberculous meningitis in an immunocompetent adult: contribution of cerebral imaging techniques to the diagnosis and follow-up]
- Author
-
D, Louvel, P, Babo, J P, Sollet, F, Barret, J N, Tillier, and P, Davous
- Subjects
Adult ,Male ,Tuberculosis, Meningeal ,Brain ,Humans ,Middle Aged ,Tomography, X-Ray Computed ,Immunocompetence ,Magnetic Resonance Imaging - Abstract
We have studied 5 men, mean age 47 years, affected by tuberculous meningitis (TM) without documented immunodepression. The diagnosis of TM was supported by clinical and biological investigations and confirmed by the cultures of CSF. All the patients received a four-drug combination therapy and steroids. No drug resistance of the bacilli was observed. Cerebral imaging by CT and MRI was rarely diagnostic but most useful during the follow-up. All the patients developed complications including tuberculomas (5), hydrocephalus (4), ischemic lesions (2), arachnoiditis (1) and abscess of spinal cord (1). Four patients recovered and one died. The mean duration of the follow-up was 16 months. MRI was more sensitive than CT scan to identify inflammatory lesions such as granulomas, angeitis or arachnoiditis and to follow their outcome. Tuberculomas and hydrocephalus were easily diagnosed by CT scan with contrast enhancement. Recommendations of sequential imaging are suggested to identify unexpected or asymptomatic complications of TM during therapy and evaluate the outcome.
- Published
- 1999
20. [Cadasil--a new model for subcortical dementia]
- Author
-
P, Davous and D, Bequet
- Subjects
Male ,Dementia, Multi-Infarct ,Brain ,Humans ,Middle Aged ,Magnetic Resonance Imaging - Abstract
We report 3 cases of Cadasil with dementia. In the 3 cases, the dementia had a subcortical and frontal presentation. It associated behavioural symptoms, amnesia, executive functions disturbances, bradyphrenia, slowing of information processing and frontal symptoms, without aphasia, apraxia or agnosia. One patient showed overt dementia before any focal neurological sign. Imaging of the brain was consistent with subcortical infarcts and leukoencephalopathy, without involvement of the cerebral cortex. We suggest that dementia and psychoaffective disturbances are major diagnostic criteria for Cadasil. This pathology is probably a good model for the neuropsychological study and the physiopathological analysis of the concept of subcortical dementia.
- Published
- 1995
21. Transcortical alexia with agraphia following a right temporo-occipital hematoma in a right-handed patient
- Author
-
François Boller and P. Davous
- Subjects
Male ,medicine.medical_specialty ,Cognitive Neuroscience ,education ,Anomia ,Experimental and Cognitive Psychology ,Audiology ,Neuropsychological Tests ,Lateralization of brain function ,Functional Laterality ,Behavioral Neuroscience ,Aphasia ,medicine ,Humans ,Functional disconnection ,Dominance, Cerebral ,Agraphia ,Visual agnosia ,Cerebral Hemorrhage ,Cerebral Cortex ,Dyslexia, Acquired ,Brain Mapping ,Dyslexia ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Paraphasia ,Temporal Lobe ,Disconnection ,Occipital Lobe ,medicine.symptom ,Psychology ,Tomography, X-Ray Computed ,Cognitive psychology - Abstract
We describe the case of a 51-year-old right-handed man who was affected by a transcortical alexia with agraphia and aphasia. Transcortical alexia produces errors in both reading and writing while copying is preserved. The patient had a severe alexia and was unable to read letters, words or sentences. Language examination showed mild aphasia with reduced fluency, intermittent paraphasia but a good comprehension and a normal repetition. Spontaneously and from dictation, writing was impaired by an agraphic jargon, but copying was excellent even though the patient was unable to read his own written production. There was no visual agnosia nor hemianopia. CT scan and MRI of the brain showed that there was a single right temporo-occipital hemorrhage but no lesion in the left hemisphere. Following surgical evacuation of the hematoma, the patient improved. One month after onset, his language was quite intact and reading was possible. We hypothesize that this particular syndrome was the result of a double disconnection: alexia would result from a disconnection of the right angular gyrus and the occipital associative areas by a subangular lesion; agraphia would result from a disconnection of the right angular gyrus and the semantic store, probably located in the right hemisphere.
- Published
- 1994
22. [Cerebral hemorrhage disclosing metastatic choriocarcinoma]
- Author
-
J, De Sèze, T, Iyriboz, A, Boutan-Laroze, and P, Davous
- Subjects
Adult ,Fatal Outcome ,Brain Neoplasms ,Pregnancy ,Uterine Neoplasms ,Humans ,Female ,Choriocarcinoma ,Magnetic Resonance Imaging ,Cerebral Hemorrhage - Abstract
We report the case of a 28-year-old woman who presented with multiple episodes of cerebral bleeding secondary to a choriocarcinoma with brain, lung and abdominal metastases, which had been partially treated 1 year before. The diagnosis was confirmed by a-high serum beta HCG level. This case emphasizes the importance of suspecting an underlying choriocarcinoma and obtaining a serum beta HCG level in young women presenting with a cerebral haemorrhage.
- Published
- 1994
23. [Chorea disclosing polycythemia and renal adenocarcinoma]
- Author
-
J M, Chamouard, A, Smagghe, B H, Malalanirina, P, Davous, and M, Poisson
- Subjects
Aged, 80 and over ,Chorea ,Remission Induction ,Humans ,Female ,Polycythemia ,Adenocarcinoma ,Nephrectomy ,Kidney Neoplasms ,Aged - Abstract
A 79-year-old woman had chorea complicating polycythaemia. The polycythaemia and the chorea disappeared after surgical removal of a renal carcinoma. The literature on polycythaemic chorea is reviewed and its pathophysiology discussed.
- Published
- 1992
24. [Total deafness after multiple pontine infarctions. Dolichoectasia of the basilar trunk]
- Author
-
P, Davous, J N, Tillier, and J, Torrent
- Subjects
Male ,Basilar Artery ,Pons ,Humans ,Cerebral Infarction ,Deafness ,Middle Aged ,Dilatation, Pathologic - Abstract
A 54 year-old man was affected by three successive infarctions in the vertebro-basilar territory. These infarctions were related to a dolichoectatic basilar artery visualized by arteriography and NMR. Deafness occurred first on the left side and then, after the third infarction, on the right side. The authors underline that deafness can be observed after a pontine infarction in the territory of the anterior inferior cerebellar artery. A dolichoectatic basilar artery can be the source of thrombotic or embolic strokes. Their prevention by antiaggregant or anticoagulant therapy is suggested.
- Published
- 1991
25. [Mitochondrial encephalopathy affecting only the central nervous system]
- Author
-
P, Davous, P, Khoubesserian, P, Tric, and N, Telerman-Toppet
- Subjects
Adult ,Brain Diseases ,Biopsy ,Humans ,Female ,Tomography, X-Ray Computed ,Follow-Up Studies ,Mitochondria, Muscle - Abstract
A 32 year-old diabetic woman presented with an acute coma followed by epileptic seizures, aphasia and constructive apraxia. No ischemic lesion was demonstrated by CT scan and carotid angiograms. The other investigations showed sensorineural hearing loss, retinal degeneration, calcifications of the basal ganglia and lactic acidosis. The follow-up was marked by pseudo-dementia with personality disorders, memory deficits, behavioural changes, migrainous and epileptic features. Although there was no sign of muscular deficiency, a muscular biopsy showed characteristic ragged-red fibers and mitochondrial abnormalities at electron microscopy. The muscular biopsy enables us to classify this case as a mitochondrial encephalopathy similar to the MELAS syndrome. The stroke-like episodes are probably caused by a specific angiopathy involving the mitochondria of brain vessels.
- Published
- 1991
26. [Familial subcortical dementia with arteriopathic leukoencephalopathy. A clinico-pathological case]
- Author
-
P, Davous and C, Fallet-Bianco
- Subjects
Male ,Dementia, Vascular ,Humans ,Female ,Cerebral Arteries ,Middle Aged ,Aged ,Demyelinating Diseases - Abstract
A 54-year-old man died after a subcortical dementia that had developed over 7 years with focal neurological signs and a stepwise course. Clinical and radiological features were similar to those of Binswanger's disease but there was no vascular risk factor, especially no hypertension. Three similar cases had occurred in the family affecting the patient's mother, her brother and sister, suggesting an autosomal dominant hereditary disease. Postmortem examination disclosed an arteriopathic leukoencephalopathy. The white matter was mainly affected in the periventricular areas of the frontal and parietal lobes with myelin loss and pallor, sparing the U fibers. The vascular changes involved the small vessels and were not arteriosclerotic. There was severe thickening of the internal lamina and degradation products of the elastic fibers. There was no amyloid. This vascular leukoencephalopathy was different from Binswanger's disease and amyloid angiopathy. We think that the vascular lesions could correspond to a genetically transmitted specific degenerative pathology of the small arteries of the brain.
- Published
- 1991
27. [Vascular dementia]
- Author
-
P, Davous
- Subjects
Male ,Alzheimer Disease ,Risk Factors ,Dementia, Vascular ,Humans ,Female ,Magnetic Resonance Imaging ,Aged - Published
- 1991
28. [Neuropathologic validation of clinical diagnosis of senile dementia of the Alzheimer type]
- Author
-
P, Davous, C, Fallet-Bianco, Y, Lamour, and M, Roudier
- Subjects
Aged, 80 and over ,Diagnosis, Differential ,Male ,Neurons ,Dementia, Multi-Infarct ,Alzheimer Disease ,Dementia, Vascular ,Brain ,Humans ,Female ,Middle Aged ,Hippocampus ,Aged - Abstract
The purpose of this work was to establish a neuropathological confirmation of the clinical diagnosis of senile dementia of the Alzheimer type (SDAT) in a group of patients prospectively studied in a geriatric hospital since 1984 (Charles Richet Study). The sample consisted of 45 cases, 35 of which had received a clinical diagnosis of SDAT and 10 others a diagnosis of either vascular or mixed dementia. The mean age at death was 85 +/- 6.9 years (range 64-97). The neuropathological diagnosis was established independently of the clinical findings. Senile lesions typical of SDAT were found in 32/35 cases, giving a 91.4% rate of clinico-pathologic agreement. However, vascular lesions were present in 10 cases (28.5%) and the final pathologic diagnosis was mixed dementia, lowering the score of agreement for SDAT to 63%. Considering that the pathological criteria for the diagnosis of SDAT are not uniform, we independently applied 3 inclusion (senile lesions) and 3 exclusion (vascular lesions) criteria for the diagnosis of SDAT to each of the 45 cases. This permitted a comparison of nine combinations of neuropathological criteria with the clinical diagnosis. The sensitivity values ranged from 37 to 80% and the specificity values ranged from 55 to 100%. The highest agreement rate with the clinical diagnosis was achieved when were associated the criterion which specified that plaques and tangles must be present in the hippocampus regardless of neocortical findings and the criterion which excluded cases with vascular lesions of any site if their volume was 50 ml or more.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1991
29. [Neuropathologic study of 50 cases of senile dementia]
- Author
-
C, Fallet-Bianco, M, Roudier, Y, Lamour, and P, Davous
- Subjects
Aged, 80 and over ,Male ,Dementia, Vascular ,Brain ,Amyloidosis ,Middle Aged ,Cerebrovascular Disorders ,Thiazoles ,Alzheimer Disease ,Humans ,Dementia ,Female ,Benzothiazoles ,Prospective Studies ,Aged ,Fluorescent Dyes - Abstract
Fifty brains from patients prospectively studied in a geriatric hospital (Charles Richet Study) were examined pathologically. The patients were senile (mean age: 85) and demented and had been clinically diagnosed as senile dementia of Alzheimer type (SDAT), vascular or multi-infarct dementia (VD), mixed dementia (MD). The whole brain was studied after formalin fixation and coronal sections. The senile changes were quantified in 6 neocortical areas, hippocampus and amygdala and subcortical structures after staining by thioflavine--S and Bodian's method. The other vascular and degenerative lesions were semiquantitatively studied. Three groups of patients were identified after microscopic examination: 1. SDAT (n = 27), 2. VD (n = 6), 3. MD (n = 15), 2 patients had no significant pathological correlate for dementia. Comparison of thioflavine S and Bodian's method in 30 cases showed the former to be more sensitive for the identification of senile plaques. In SDAT, 13/27 brains lacked neurofibrillary tangles in the neocortex. Amyloid angiopathy was observed in 78% of the brains but lacked in 5/6 cases affected by pure VD. Significant lesions of the substantia nigra were observed in 13 cases with typical features of Parkinson's disease in 2 cases. The locus coeruleus was affected mainly in SDAT cases (20/27) and in some cases of VD or MD (6/21). The raphe nuclei showed neuronal loss in 18% of the cases, mostly SDAT. In this series of cases, neocortical neurofibrillary tangles could be lacking in SDAT. Amyloid angiopathy was almost always present in SDAT and MD. Subcortical structures involved in cholinergic, noradrenergic and serotoninergic innervation of the cortex were more severely impaired in SDAT and MD than in VD. Mixed dementia was frequent in these very old demented patients. Clinical and pathological criteria are needed to identify this group of patients.
- Published
- 1990
30. A Comparison of 'Pure' Alzheimer’s Disease and Alzheimer’s Disease Plus Vascular Lesions (Mixed Dementia) in the Elderly
- Author
-
Yvon Lamour, P. Davous, C. Fallet-Bianco, and M. Roudier
- Subjects
Pediatrics ,medicine.medical_specialty ,business.industry ,Neuropathologist ,Neuropsychology ,Disease ,medicine.disease ,Mixed dementia ,mental disorders ,Medicine ,Dementia ,Alzheimer's disease ,business ,Vascular dementia ,Pathological - Abstract
It is widely accepted that senile dementia of the Alzheimer type and dementia due to vascular lesions are the two most common kinds of dementia in the elderly. However, the clinical criteria required to differentiate these two major progressive dementias are still unreliable (1, 2, 3). Furthermore, it has been shown (4, 5) that there were difficulties in classifying patients based on morphologic findings. Validation studies by Tierney et al (6) and Davous et al (7) demonstrated that depending on the neuropathological criteria applied, the same patients could be classified as Alzheimer’s disease or mixed dementia. In order to investigate further the concept of mixed dementia, we established a comparison of neurological, neuropsychological and pathological findings in 2 groups of patients prospectively studied and referred independently by the neuropathologist as “pure” Alzheimer’s disease (AD) and Alzheimer’s disease plus vascular lesions or mixed dementia (MD).
- Published
- 1990
- Full Text
- View/download PDF
31. P066 - Défis de la vaccination contre la COVID-19 en Côte d'Ivoire: connaissances, perception et confiance des populations vis-à-vis des vaccins anti-COVID
- Author
-
Agbé, B., Traoré, Y., Diarrassouba, M., Serigne, N., Messou, E., and Aby-Davous, A.
- Abstract
La vaccination a le plus souvent fait l'objet de méconnaissances voire de fausses informations pouvant aboutir à de la méfiance voire de la réticence de la part des populations. Le caractère pandémique de la COVID-19 avec un développement relativement rapide des vaccins utilisant des techniques nouvelles (vaccins à ARN messager) peut exposer à des niveaux de méfiance importants rendant des stratégies vaccinales moins efficaces surtout en Afrique. L'objectif de cette enquête était de faire un état de lieu des connaissances, perception, confiance vis-à-vis des vaccins anti-COVID à Abidjan (épicentre de l’épidémie) et d'identifier leurs facteurs associés.
- Published
- 2023
- Full Text
- View/download PDF
32. Claudication intermittente par ischémie des racines nerveuses lombaires : test diagnostique et thérapeutique à l'ilomédine
- Author
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P. Davous, M. Gayraud, and J. Cosserat
- Subjects
Gastroenterology ,Internal Medicine - Published
- 2001
- Full Text
- View/download PDF
33. Cerebral infarction and familial protein S deficiency
- Author
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Jacqueline Conard, P Davous, Marie Hélène Horellou, and Meyer-Michel Samama
- Subjects
Advanced and Specialized Nursing ,Text mining ,business.industry ,Cerebral infarction ,medicine ,Neurology (clinical) ,Protein S deficiency ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business ,Bioinformatics - Published
- 1990
- Full Text
- View/download PDF
34. Droit de savoir – droit à l’ignorance, aspects éthiques et psychologiques en oncogénétique pédiatrique
- Author
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Weil-Dubuc, P.-L., Seigneur, E., Margerit-Bonnecuelle, D., Asselain, B., Auvrignon, A., Bontems, D., Buitrago, J., Cerny, C., Fresneau, B., Genevoix, A.-S., Martin, M., Souyri, V., Vialle, G., Davous, D., and Bourdeaut, F.
- Abstract
La génétique somatique et constitutionnelle prend une place grandissante dans la pratique de l’onco-hématologie pédiatrique. Cette accélération tient d’abord aux avancées technologiques et aux forces de poussées qu’exerce la recherche sur des maladies menaçantes, de ce fait considérée comme impérieuse. Les demandes des familles elles-mêmes sont susceptibles d’être influencées par la compréhension qu’elles auront de « la génétique » et l’explicitation qu’on leur donne des enjeux réels, ni minimisés, ni fantasmés. Le groupe « Parents et soignants face à l’éthique en pédiatrie » a réuni parents, soignants et un philosophe pour travailler sur les enjeux éthiques des investigations génétiques dans notre contexte professionnel. Un livret d’information destiné aux parents a concrétisé ce travail. Cet article propose de concentrer l’essentiel des questions éthiques abordées dans ce groupe par une dialectique résumée par la formule « droit de savoir, droit à l’ignorance ». Sans amener à des solutions définitives, l’article conclut en donnant des repères philosophiques pour orienter les décisions.
- Published
- 2015
- Full Text
- View/download PDF
35. Pharmacological modulation of cortisol secretion and dexamethasone suppression in alzheimer's disease
- Author
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C. Abramowitz, P. Davous, M.L. Piketty, Yvon Lamour, and M. Roudier
- Subjects
Male ,Cortisol secretion ,medicine.medical_specialty ,Physostigmine ,Hydrocortisone ,Clonidine ,Dexamethasone ,Alzheimer Disease ,Internal medicine ,medicine ,Humans ,Dementia ,Biological Psychiatry ,Aged ,Aged, 80 and over ,Depressive Disorder ,medicine.disease ,Endocrinology ,Dexamethasone suppression test ,Cholinergic ,Female ,Alzheimer's disease ,Psychology ,medicine.drug - Abstract
We have investigated the dexamethasone suppression of cortisol release in a group of 28 patients with senile dementia of the Alzheimer type (SDAT) after stimulation by physostigmine and donidine, as compared with basal conditions. All patients but one had previously been evaluated with a depression symptom checklist and had submitted to a standard Dexamethasone Suppression Test (DST). SDAT patients showed normal baseline cortisol values measured at 4:00 pm . DST was reproducible, but nonsuppression did not appear to be a feature of the disease, nor of the dementia syndrome, although a majority of the most demented patients were found to be nonsuppressors. Physostigmine stimulated cortisol secretion in 20 of 24 cases, irrespective of the severity of dementia. Clonidine induced a secretion in 12 of 15 cases, but this was less than that observed after cholinergic stimulation. Physostigmine made cortisol release significantly less sensitive to the suppressive effect of dexamethasone than donidine in SDAT. This double response should be tested as a possible predictor of a cholinergic therapeutic effect.
- Published
- 1988
- Full Text
- View/download PDF
36. A comparative evaluation of the short orientation memory concentration test of cognitive impairment
- Author
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P Rondot, Y Lamour, P Davous, and E Debrand
- Subjects
Adult ,Male ,medicine.medical_specialty ,Audiology ,Logical address ,Raven's Progressive Matrices ,Alzheimer Disease ,Memory ,medicine ,Humans ,Dementia ,Psychiatry ,Aged ,Aged, 80 and over ,Psychiatric Status Rating Scales ,Mini–Mental State Examination ,medicine.diagnostic_test ,Mental Disorders ,Wechsler Adult Intelligence Scale ,Middle Aged ,medicine.disease ,Short orientation - memory - concentration test ,Psychiatry and Mental health ,Female ,Surgery ,Neurology (clinical) ,False positive rate ,Nervous System Diseases ,Alzheimer's disease ,Cognition Disorders ,Psychology ,Research Article - Abstract
In order to assess the relative sensitivity and specificity of Katzman's short orientation memory concentration test (OMCT), 89 non demented patients and 44 patients affected by vascular or degenerative dementia were consecutively evaluated by three different mental status tests. The OMCT appeared equivalent to the Mini Mental State Examination in identifying dementia. Optimum sensitivity and specificity, respectively 88% and 94%, were achieved by a 10/11 cut-off score, giving a 11% false positive rate. Among patients with Alzheimer's disease, the OMCT score was correlated with mean values of a simple reaction time. It was also correlated with the Wechsler global MQ and the orientation, logical memory and paired associates items of the scale. There was no relationship between the OMCT score and the coloured Progressive Matrices IQ. The OMCT was reliable when given at 1 month interval. Serial evaluations did not show any significant practice effect.
- Published
- 1987
- Full Text
- View/download PDF
37. Serum neuron-specific enolase in senile dementia of the Alzheimer type
- Author
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H. Scarna, Yvon Lamour, M. Roudier, P. Davous, and S. Safer
- Subjects
Male ,endocrine system ,medicine.medical_specialty ,Pathology ,Enolase ,Significant negative correlation ,Alzheimer Disease ,Internal medicine ,Blood plasma ,medicine ,Humans ,Dementia ,Aged ,Aged, 80 and over ,General Neuroscience ,Healthy elderly ,medicine.disease ,Endocrinology ,medicine.anatomical_structure ,nervous system ,Ageing ,Phosphopyruvate Hydratase ,Female ,Neuron ,Alzheimer's disease ,Psychology - Abstract
The level of neuron-specific enolase (NSE), a glycolytic enzyme localized in neurons, was measured in the serum of patients with senile dementia of the Alzheimer type (SDAT). No difference was observed between NSE levels in SDAT and in healthy elderly controls of the same age range. No correlation was found between NSE levels and severity of the cognitive deficits. There was a marginally significant negative correlation between age and NSE, younger patients having higher NSE levels. The present results suggest that serum NSE is not a useful biological marker in the senile form of the dementia of the Alzheimer type.
- Published
- 1988
- Full Text
- View/download PDF
38. Menzel's hereditary ataxia with slow eye movements and myoclonus
- Author
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P. Rondot, C. Vedrenne, P. Davous, and J. de Recondo
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities ,Ataxia ,Cerebellar ataxia ,business.industry ,Paramedian pontine reticular formation ,Anatomy ,Spinal cord ,Dyssynergia ,medicine.anatomical_structure ,Dentate nucleus ,Superior cerebellar peduncle ,Neurology ,medicine ,Neurology (clinical) ,medicine.symptom ,business ,Myoclonus - Abstract
The patient we describe had cerebellar ataxia, slow eye movements, myoclonus, facial dystonia and signs of spinal cord and peripheral nerve involvement. The patient's mother, brother and sister died from the same disease. Neuropathological examination revealed lesions of olivo-ponto-cerebellar atrophy (OPCA) associated with spinal cord degenerative changes characteristic of Menzel's hereditary ataxia. Although myoclonus was similar to Hunt's dyssynergia cerebellaris myonica, pathological findings did not show significant involvement of the dentate nucleus or superior cerebellar peduncle and physiopathological hypotheses for myoclonus are discussed. Slow eye movement is emphasized in the propositus and we suggest that it could be specific of one type of OPCA. Its pathological significance is discussed, but a primitive and unique involvement of the paramedian pontine reticular formation is unlikely.
- Published
- 1983
- Full Text
- View/download PDF
39. Correlations between memory, language, gnosia, and praxia in 80 patients with senile dementia of the alzheimer type
- Author
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M. Roudier, P. Marcie, P. Davous, N. Podrabinek, and Yvon Lamour
- Subjects
medicine.medical_specialty ,Neuropsychology ,Audiology ,medicine.disease ,Test (assessment) ,Nonverbal communication ,Severe dementia ,mental disorders ,Drug Discovery ,medicine ,Dementia ,In patient ,Alzheimer's disease ,Set (psychology) ,Psychology ,Psychiatry - Abstract
A global neuropsychological study has been carried out with 80 in-patients presenting a syndrome of senile dementia of the Alzheimer type (SDAT):60 scored less than 20 (mild dementia) on the Mini-Mental Test Examination (MMSE); 20 scored less than 10 (severe dementia). The test battery included a set of tasks exploring memory, language, abstract nonverbal thought, gnosias, and praxias. In patients with mild dementia, the overall MMSE score was statistically correlated with the scores for memory, nonverbal thought, language, and gnosias, but not with the score for praxia. Language score was correlated with the scores for the other higher functions. It is suggested that the SDAT syndrome has to be considered as a unique syndrome affecting every higher function quite similarly, with no evidence of clinical subgroups. With this in mind, new studies should be designed to delineate further the role of the mnesic, linguistic, and/or perceptual factors involved in the dementia process.
- Published
- 1988
- Full Text
- View/download PDF
40. Complexes triamminés du rhodium(III) I. Un nouveau complexe du rhodium(III): La rhodium(III)-trihydroxo-triammine préparation, identification et étude de quelques unes de ses propriétés physico-chimiques
- Author
-
G. Pannetier, V. Huynh, R. Bonnaire, P. Davous, and P. Alépée
- Subjects
General Engineering - Abstract
Resume L'action de l'ammoniaque sur l'acide hexachlororhodique bouillant en presence d'eau oxygenee concentree conduit a un compose nouveau, peu soluble, que divers essais qualitatifs (analyse chromatographique et spectrometrie de masse des gaz de decomposition, spectrophotometrie d'absorption infrarouge) et quantitatifs (titre en metal, dosage de la vapeur d'eau degagee par thermolyse sous vide) ont montre avoir pour formule [Rh(OH)3(NH3)3]0. Nous avons egalement fait, en fonction de la temperature, l'analyse du comportement de ce compose dans diverses atmospheres: alors qu'en chauffage lent sous azote nous obtenons un melange de rhodium metallique et de Rh2O3, nous aboutissons au metal sous hydrogene et a Rh2O3 pur sous oxygene; les temperatures ou commencent les reactions observees ont ete precisees dans chaque cas. Le produit prepare, qui est la rhodium(III)-trihydroxo-triammine doit a ses groupements oxhydriles une tres grande reactivite: il est attaque par tous les acides: chlorhydrique, sulfurique, nitrique, perchlorique et acetique en particulier pour donner les derives triammines correspondants.
- Published
- 1969
- Full Text
- View/download PDF
41. Complexes triamminés du rhodium(III) II. Préparation de la rhodium(III)-trichloro-triammine à partir de la rhodium(III)-trihydroxo-triammine étude de son spectre infrarouge et de sa dégradation thermique dans diverses atmosphères
- Author
-
P. Davous, P. Alépée, V. Huynh, G. Pannetier, and R. Bonnaire
- Subjects
General Engineering - Abstract
Resume L'action de l'acide chlorhydrique concentre sur [Rh111(OH)3(NH3)3]0 donne un precipite jaune, legerement orange, quasi insoluble dans l'acide et dans l'eau et non-electrolyte. Ce produit donne par pyrolyse en atmosphere inerte: de la mousse de rhodium, du chlorure d'ammonium, de l'acide chlorhydrique et de l'azote. Sa teneur en chlore a ete determinee par argentimetrie sur ses produits de pyrolyse sous vide en ampoule scellee; elle correspond, ainsi que son titre en rhodium, au complexe vrai [Rh111Cl3(NH3)3]0. Cette formule a ete confirmee par des essais divers: conductibilite, Chromatographie des gaz emis en cours de decomposition, spectrographie infrarouge etc. L'analyse thermogravimetrique en atmosphere inerte conduit au rhodium a 336 °C; par reduction sous hydrogene, on l'obtient a 260 °C; sous oxygene on passe par l'intermediaire du trichlorure de rhodium. Son spectre d'absorption infrarouge est en parfait accord avec les resultats precedents; il revele neanmoins une grande complexite dans la region des faibles frequences; ceci permet de rejeter pour ce precipite la formule [RhCl(NH3)5]3 [RhCl6]2 ou (RhCl3(NH3)3)5 qui en ferait un hexachlororhodite de rhodium(III) chloro-pentammine.
- Published
- 1969
- Full Text
- View/download PDF
42. CADASIL: a review with proposed diagnostic criteria
- Author
-
Davous, P.
- Abstract
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) can be considered as a new disease predominantly affecting the small vessels of the brain with an autosomal dominant transmission linked to chromosome 19. This review includes an historical perspective showing how the disease was identified from the spectrum of vascular leukoencephalopathies. More than two hundred patients have now been described, belonging to at least 30 unrelated pedigrees in Europe, America and Asia. The clinical features include four major neurological presentations associated in variable degrees during the course of the disease: migraine with or without aura, strokes or stroke‐like episodes, major psychiatric symptoms and dementia. The patients are free of the classical vascular risk factors. The disease has a progressive or stepwise course with age at onset in the forties and a mean duration of 13.6 I 10.7 years. Death occurs in the fifties in a characteristic condition associating a pseudo‐bulbar syndrome and subcortical dementia. Cerebral magnetic resonance imaging (MRI) is highly contributive to the diagnosis, showing a diffuse leukoencephalopathy with subcortical infarcts in the basal ganglia and white matter. Pathological data show macroscopic lesions similar to Binswanger's disease but different lesions of the small vessels including thickening of the media, characteristic PAS+ granular material and narrowing of the lumen. Skin biopsy may be a valuable diagnostic tool, showing ultrastructural alterations of skin vessels similar to those of brain vessels. The disease is highly homogeneous on a genetic basis and the identification of the gene Notch 3 on chromosome 19 has opened new avenues for research and genetic counselling. The pathogenesis of the disease has still to be elucidated. A definite diagnosis relies on genetical or pathological data. Diagnostic criteria are proposed to recognize the disease on clinical and imaging parameters. So far, no treatment has been reported to be successful for CADASIL.
- Published
- 1998
- Full Text
- View/download PDF
43. Complexes monoamminés du rhodium(III). Un nouveau complexe monoamminé du rhodium(III): La rhodium(III)-trihydroxo-diaquo-monoammine
- Author
-
P. Davous, P. Alépée, R. Bonnaire, V. Huynh, and G. Pannetier
- Subjects
General Engineering - Abstract
Resume La poudre jaune paille que l'on obtient par dessiccation du precipite forme par action de l'ammoniaque sur une solution d'acide hexachlororhodique bouillant en presence d'eau oxygenee n'est pas representee par [Rh(OH)3(NH3)3]0 ainsi qu'il a ete ecrit, mais par [Rh(OH)3(H2O)2(NH3)]0 ce qui en fait une rhodium (III)-trihydroxo-diaquo-monoammine. Les auteurs donnent les raisons de ce changement; neanmoins tout ce qui a precedemment ete ecrit sur la preparation, les proprietes physiques et chimiques et le comportement thermique de ce corps demeure valable.
- Published
- 1970
- Full Text
- View/download PDF
44. [Alzheimer's type dementia: recent data]
- Author
-
Y, Lamour and P, Davous
- Subjects
Aging ,Neurotransmitter Agents ,Alzheimer Disease ,Brain ,Humans ,Dementia ,Aged ,Aluminum ,Autoimmune Diseases - Abstract
Dementia of the Alzheimer type (DTA) is the most common form of adult-onset dementia. The clinical features of the disease include progressive memory defect, intellectual impairment and behavioral disturbances. The number of patients suffering from DTA is increasing dramatically, due to the growing proportion of old people. DTA therefore is a major public health problem. Brain lesions include several histopathological changes (mostly in the cerebral cortex and hippocampus): neurofibrillary tangles, senile plaques, granulo-vacuolar degeneration, Hirano bodies, angiopathy, loss of nerve cells. Postmortem brain examination reveals characteristic neurochemical deficits. The most consistent reduction in neurotransmitter-synthesizing enzyme observed so far is a reduction in choline acetyltransferase activity, suggesting a cholinergic deficit. However, other deficits involving noradrenaline and somatostatin have also been reported. Several hypotheses (genetic, viral, toxic, immunologic, metabolic) have been put forward in order to explain DTA. The relationship between these hypotheses and the neurochemical deficits is still unclear, but the existence of characteristic neurotransmitter-related deficits allows specific therapeutic trials.
- Published
- 1983
45. Dexamethasone suppression test in senile dementia of the Alzheimer type
- Author
-
H. Susini de Luca, Yvon Lamour, C. Abramowitz, M. Roudier, and P. Davous
- Subjects
education.field_of_study ,medicine.medical_specialty ,business.industry ,Population ,Senile dementia ,medicine.disease ,Internal medicine ,Dexamethasone suppression test ,medicine ,Etiology ,Dementia ,Alzheimer's disease ,education ,business ,Depression (differential diagnoses) - Abstract
The dexamethasone suppression test (DST) has been widely studied in depressive patients. According to Carroll (1), the average sensitivity of this test is 45% among depressed patients irrespective of the etiology of the depression. Little is known about DST results in dementia of the Alzheimer type (SDAT) and in non demented elderly patients and there are conflicting results in the literature (2–6). The purpose of the present investigation was to determine the frequency of abnormal DST responses in a population of elderly inpatients affected with SDAT compared to a group of control mentally healthy patients of similar age range.
- Published
- 1986
- Full Text
- View/download PDF
46. [Extrapyramidal rigidity with dystonia, optic atrophy and bilateral putaminal lesions in an adolescent. Juvenile form of Leigh's disease (author's transl)]
- Author
-
P, Rondot, J, de Recondo, P, Davous, D, Fredy, and F X, Roux
- Subjects
Adult ,Male ,Optic Atrophy ,Encephalomalacia ,Basal Ganglia Diseases ,Intellectual Disability ,Putamen ,Humans ,Psychomotor Disorders ,Tomography, X-Ray Computed ,Brain Stem ,Muscle Rigidity - Abstract
A 19-year-old man presented with an apparently non-familial neurological disorder that had progressed from the age of 6 years. Dystonia of the trunk and limbs with extrapyramidal rigidity, dysarthria, a pyramidal syndrome with spasticity of the lower limbs, bilateral optic atrophy, and nystagmiform ocular movements were present. CT scan demonstrated symmetrical putaminal lesions. The different aetiologies of bilateral striatal lesions are considered, the final diagnosis being a juvenile form of Leigh's disease.
- Published
- 1982
47. Comparative study of posturography and electrooculography in at-risk subjects for Huntington's disease
- Author
-
P. Davous, P. Rondot, and D. Valade
- Subjects
Adult ,Male ,Risk ,medicine.medical_specialty ,Electrodiagnosis ,Adolescent ,Eye Movements ,Posture ,Disease ,Physical medicine and rehabilitation ,Blind study ,Huntington's disease ,medicine ,Humans ,Child ,medicine.diagnostic_test ,Posturography ,Eye movement ,Electrooculography ,medicine.disease ,Huntington Disease ,Neurology ,Physical therapy ,Female ,Neurology (clinical) ,Psychology - Abstract
A simultaneous blind study of posture and eye movements was undertaken in 9 subjects at risk for Huntington's disease. After quantitative evaluation of the postural and electrooculographic abnormalities, the subjects were subdivided into subgroups, and the results were compared to test the relationship between the two methods. There was a significant correlation between the two evaluations. 5 of the 9 patients had evaluation scores which reflected abnormalities similar to those observed in patients suffering from Huntington's disease. These preliminary results suggest that posture and eye movement recordings could be tested for their predictive value in Huntington's disease.
- Published
- 1984
48. [Elementary test of concentration, orientation and memory. Application to the detection of dementia states in daily practice]
- Author
-
P, Davous and Y, Lamour
- Subjects
Aged, 80 and over ,Intelligence Tests ,Male ,Psychological Tests ,Memory ,Humans ,Attention ,Dementia ,Female ,Aged - Abstract
The authors present a french version of the Katzman short orientation memory concentration test. The 6 items of the test include 3 orientation questions, 2 mental control items and an address memory phrase. Time for administration is less than 5 minutes. This french version of the test has been validated as a measure of cognitive impairment in a population of 200 subjects including 140 patients without cognitive impairment and 60 demented subjects. As defined by a 10/11 cut-off score, sensibility and specificity for the diagnosis of dementia were 91 p. 100 and 95 p. 100 respectively. Correlation of the scores with those obtained by the Mini mental state was highly significant. This fast, easy and reliable test seems particularly suitable for the detection of cognitive impairment in clinical practice.
- Published
- 1988
49. Circulating immune complexes in multiple sclerosis. Relation to clinical and biological parameters
- Author
-
P, Davous, C M, Jacque, L, Grangeot-Keros, R, Marteau, and N, Baumann
- Subjects
Adult ,Male ,Multiple Sclerosis ,Time Factors ,Immunoglobulin G ,Age Factors ,Humans ,Female ,Antigen-Antibody Complex ,Lymphocytes ,Cerebrospinal Fluid - Abstract
Circulating immune complexes were looked for on 38 clinically definite MS (multiple sclerosis) patients compared to 35 other neurological patients and 26 healthy subjects. 29% of the MS sera and 8.6% of the other neurological sera were positive, whereas none of the control sera were positive. These differences are significant. Clinical status was analysed as regards the age at onset, the duration and course of the disease, the disability of the patients and the treatment they received. CSF (cerebrospinal fluid) parameters studied were pleocytosis, concentration of total protein, electrophoresis. The results suggest that IC (immune complex) are more frequent during the first 10 years of the MS disease, in patients with blood-brain barrier damage and in patients without oligoclonal IgG.
- Published
- 1978
50. The Hoffmann reflex (H-reflex) in senile dementia of the Alzheimer's type--preliminary results
- Author
-
Y, Lamour, J C, Willer, M, Roudier, and P, Davous
- Subjects
Aged, 80 and over ,H-Reflex ,Motor Neurons ,Leg ,Spinal Cord ,Alzheimer Disease ,Reflex, Monosynaptic ,Reaction Time ,Humans ,Female ,Aged - Abstract
The Hoffmann reflex (H-reflex) and direct motor response (M) were investigated (latency, amplitude and excitability curves were analyzed) in patients with senile dementia of the Alzheimer's type (SDAT). M responses had similar latencies in SDAT patients and old control subjects. H reflex latencies were similar in SDAT patients and old control subjects but longer than in younger controls. The H max/M max ratio was also lower in SDAT patients and old control subjects than in younger controls. The excitability curve of the H-reflex (using a double shock procedure) in SDAT patients was lower than in non-demented old controls for all values of the interstimulus intervals.
- Published
- 1987
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