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8. Abstracts

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Derlon J. M., Petit-taboué M. C., Dauphin F., Courtheoux P., Chapon F., Creissard P., Darcel F., Houtteville J. P., Kaschten, B., Sadzot, B., Stevenaert, A., Tjuvajev, Juri G., Macapinlac, Homer A., Daghighian, Farhad, Ginos, James Z., Finn, Ronald D., Jiaju Zhang, M. S., Beattie, Bradley, Graham, Martin, Larson, Steven M., Blasberg, Ronald G., Levivier, M., Goldman, S., Pirotte, B., Brucher, J. M., Balériaux, D., Luxen, A., Hildebrand, J., Brotchi, J., Go K. G., Kamman R. L., Mooyaart E. L., Heesters M. A. A. M., Sijens, P. E., Oudksrk, M., van Dijk, P., Levendag, P. C., Vecht, Ch. J., Metz, R. J., Kennedy, D. N., Rosen, B. R., Hochberg, F. H., Fishman, A. J., Filipek, P. A., Caviness, V. S., Gross, M. W., Weinzierl, F. X., Trappe, A. E., Goebel, W. E., Frank, A. M., Becker, Georg, Krone, Andreas, Schmidt, Karsten, Hofmann, Erich, Bogdahn, Ulrich, Bencsch, H., Fclber, S., Finkenstedt, G., Kremser, C., Sfockhammer, G., Aichner, F., Bogdahn U., Fröhlich T., Becker G., Krone A., Schlief R., Schürmann J., Jachimczak P., Hofmann E., Roggendorf W., Roosen K., Carapella, C. M., Carpinelli, G., Passalacqua, R., Raus, L., Giannini, M., Mastrostefano, R., Podo, F., Tofani, A., Maslrostefano, R., Mottoles, M., Ferraironi, A., Scelsa, M. G., Oppido, P., Riccio, A., Maini, C. L., Collombier, L., Taillandier, L., Dcbouverie, M., Laurens, M. H., Thouvenot, P., Weber, M., Bertrand, A., Cruickshank G. S., Patterson J., Hadley D., De Witte, Olivier, Hildebrand, Jerzy, Luxen, André, Goldman, Serge, Ernestus, R. -I., Bockhorst, K., Eis, M., Els, T., Hoehn-Berlage, M., Gliese, M., Fründ, R., Geissler, A., Woertgen, C., Holzschuh, M., Goldman, Serge, Levivier, M., Pirotte, B., Brucher, J. M., Luxen, A., Brotchi, J., Hildebrand, J., Hausmann, O., Merlo, A., Jerrnann, E., Uirich, J., Chiquet-Ehrismann, R., Müller, J., Mäcke, H., Gratzl, O., Herholz, K., Ghaemi, M., Würker, M., Pietrzyk, U., Heiss, W. -D., Kotitschke, K., Brandl, M., Tonn, J. C., Haase, A., Bogdahn, U., Kotitschke, K., Muigg, S., Felber, S., Aichner, F., Haase, A., Bogdahn, U., Krone A., Becker G., Woydt M., Roggendorf W., Hofmann E., Bogdahn U., Roosen K., Lanfermann, Heinrich, Heindel, Walter, Kugel, Harald, Erneslus, Ralf -Ingo, Röhn, Gabricle, Lackner, Klaus, Metz, R. J., Kennedy, D. N., Pardo, F. S., Kutke, S., Sorensen, A. G., Hochberg, F. H., Fishman, A. J., Filipek, P. A., Rosen, B. R., Caviness, V. S., Mechtler, L. L., Withiam-Lench, S., Shin, K., Klnkel, W. R., Patel, M., Truax, B., Kinkel, P., Shin, K., Mechtler, L., Ricci M., Pantano P., Maleci A., Pierallini S., Di Stefano D., Bozzao L., Cantore G. P., Röhn, Gabriele, Els, T., Schröder, R., Hoehn-Berlage, M., Ernestus, R. -I., Ruda, R., Mocellini, C., Soffietti, R., Campana, M., Ropolo, R., Riva, A., de Filippi, P. G., Schiffer, D., Salgado D., Rodrigues M., Salgado L., Fonseca A. T., Vieira M. R., Bravo Marques J. M., Satoh, H., Uozumi, T., Kiya, K., Kurisu, K., Arita, K., Sumida, M., Ikawa, F., Tzuk-Shina, Tz., Gomori, J. M., Rubinstein, R., Lossos, A., Siegal, T., Vaalburg, W., Paans, A. M. J., Willemsen, A. T. M., van Waarde, A., Pruim, J., Visser, G. M., Go, K. G., Valentini, S., Ting, Y. L. T., De Rose, R., Chidichimo, G., Corricro, G., van Lcycn-Pilgram, Karin, Erncslus, Ralf -Ingo, Klug, Norfried, van Leyen-Pilgram, K., Ernestus, R. -I., Schröder, R., Klug, N., Woydt M., Krone A., Tonn J. C., Becker G., Neumann U., Roggendorf W., Roosen K., Plate, Karl H., Breier, Georg, Millaucr, Birgit, Weich, Herbert A., Ullrich, Axel, Risau, Werner, Roosen N., Chopra R. K., Mikkelsen T., Rosenblum S. D., Yan P. S., Knight R., Windham J., Rosenblum M. L., Schiffer, D., Attanasio, A., Cavalla, P., Chio, A., Giordana, M. T., Migheli, A., Amberger, V., Hensel, T., Schwab, M. E., Cervoni, Luigi, Celli, Paolo, Tarantino, Roberto, Huettner, C., Tonn, J. C., Berweiler, U., Roggendorf, W., Salmon, I., Rorive, S., Rombaut, K., Pirotte, B., Haot, J., Brotchi, J., Kiss, R., Maugard-Louboutin C., Charrier J., Fayet G., Sagan C., Cuillioere P., Ricolleau G., Martin S., Menegalli-Bogeelli D., Lajat Y., Resche F., Molnàr, Péter, Bárdos, Helga, Ádány, Róza, Rogers, J. P., Pilkington, G. J., Pollo, B., Giaccone, G., Allegranza, A., Bugiani, O., Prim, J., Badia, J., Ribas, E., Coello, F., Shezen, E., Lossos, A., Abramsky, O., Siegal, T., Scerrati M., Roselli R., Iacoangeli M., Pompucci A., Rossi G. F., Deeb, Saleh M. Al., Koreich, Osama, Yaqub, Basim, Moutaery, Khalaf R. Al., Giordana, M. T., Cavalla, P., Chio, A., Marino, S., Vigliani, M. C., Schiffer, D., Deburghgraeve, V., Darcel, F., Gedouin, D., Hassel, M. Ben, Guegan, Y., Jeremic, B., Grujicic, D., Antunovic, V., Matovic, M., Shibamoto, Y., Kallio, Merja, Huhmar, Helena, Kudoh, Ch., Detta, A., Sugiura, K., Hitchcock, E. R., Mastrostefano, R., Di Russo, R., Cipriani§, M., Occhipinti, E. M., Conti, E. M. S., Clowegeser A., Ortler M., Seiwald M., Kostron H., Rajan B., Ross G., Lim C., Ashlcy S., Goode D., Traish D., Brada M., Sanden, G. A. C. vd, Schouten, L. J., Coebergh, J. W. W., Razenberg, P. P. A., Twijnstra, A., Snilders-Keilholz, A., Voormolen, J. H. C., Hermans, J., Leer, J. W. H., Taillandier, L., Baylac, F., Dcbouvcrie, M., Anxionnal, R., Bracard, S., Vignand, J. M., Duprcz, A., Weber, M., Winking, M., Böker, D. K., Simmet, T., Rothbart, David, Strugar, John, Balledux, Jeroen, Criscuolo, Gregory R., Jachimczak, Piotr, Blesch, Armin, Heβdörfer, Birgit, Bogdahn, Ulrich, Ernestus, Ralf -Ingo, Schröder, Roland, Klug, Norfrid, Krouwer, H. G. J., Duinen, S. G. v., Algra, A., Zentner, J., Wolf, H. K., Ostertun, B., Hufnagel, A., Campos, M. G., Solymosi, L., Schramm, J., Newlands, E. S., O'Reilly, S. M., Brampton, M., Soffietti, R., Chio, A., Mocellini, C., Ruda, R., Vigliani, M. C., Schiffer, D., Sciolla, R., Seliak, D., Henriksson, R., Bergenheim, A. T., Björk, P., Gunnarsson, P. -O., Hariz, Ml., Grant, R., Collie, D., Gregor A., Ebmeier K. P., Jarvis G., Lander F., Cull A., Sellar R., Brada, M., Thomas, C., Elyan, S., Hines, F., Ashley, S., Stenning, S., Bernstein J. J., Goldberg W. J., Roelcke U., Von Ammon K., Hausmann O., Radu E. W., Kaech D., Leenders K. L., Fitzek, II, M. M., Aronen J. Efird, Hochberg, F., Gruber, M., Schmidt, E., Rosen, B., Flschman, A., Pardo, P., Afra U. M. U., Sipos, L., Slouik, F., Boiardi A., Salmaggi A., Pozzi A., Farinotti L., Fariselli L., Silvani A., Brandes, A., Scelzi, E., Rigon, A., Zampieri, P., Pignataro, M., Amanzo, P. D'., Amista, P., Rotilio, A., Fiorentino, M. V., Thomas, R., Brazil, L., O'Connor, A. M., Ashley, S., Brada, M., Salvati, Maurizio, Cervoni, Luigi, Puzzilli, Fabrizio, Cervoni, Luigi, Salvati, Maurizio, Raguso, Michele, Cruickshank G. S., Duckworth R., Rumpling R., Rottuci M., Fariselli L., Boiardi A., Broggi G., Plrint, N. G., Sabattini, E., Manetto, V., Gambacorta, H., Poggi, S., Pileri, S., Ferracini, R., Grant, R., Plev D. V., Hopf N. J., Knosp E., Bohl J., Perncczky A., Kiss, R., Salmon, I., Catnby, I., Dewitte, O., Brotchi, J., Pasteels, J. L., Camby, I., Salmon, I., Darro, F., Danguy, A., Brotchi, J., Pasteels, J. L., Kiss, R., Kiu, M. C., Lai, G. M., Yang, T. S., Ng, K. T., Chen, J. S., Chang, C. N., Leung, W. M., Ho, Y. S., Rychter, M. Deblec, Klimek, A., Liberski, P. P., Karpinaka, A., Krauseneck P., Schöffel V., Müller B., Kreth, F. W., Faist, M., Warnke, P. C., Ostertag, C. B., Nielen, K. M. B. v., Visscr, M. C., Lebrun C., Lonjon M., Desjardin T., Michiels J. F., Chanalet Sa. Lagrange J. L., Roche J. L., Chatel M., Mastronardi L., Puzzilli F., Osman Farah J., Lunardi P., Matsutani, M., Ushio, Y., Takakura, K., Menten, Johan, Hamers, Han, Ribot, Jacques, Dom, René, Tcepen, Hans, Müller B., Weidner N., Krauseneck P., Naujocks, G., van Roost, D., Wiestler, O. D., Kuncz, A., Nieder, C., Setzel-Sesterhein, M., Niewald, M., Schnabel, I., O'Neill, K. S., Kitchen, N. D., Wilkins, P. R., Marsh, H. T., Pierce, E., Doshi, R., Deane, R., Previtali, S., Quattrini, A., Nemni, R., Ducati, A., Wrabetz, L., Canal, N., Punt, C. J. A., Stamatakis, L., Giroux, B., Rutten, E., Quigley, Matthew R., Beth Sargent P. A. -C., Flores, Nicholas, Simon, Sheryl, Maroon, Joseph C., Quigley, Matthew R., Beth Sargent P. A. -C., Flores, Nicholas, Maroon, Joseph C., Rocca A. A., Gervasoni C., Castagna A., Picozzi P., Giugni E., Rocca A. A., Tonnarelli G. P., Ducati A., Mangili F., Truci G., Canal N., Giovanelli M., Roelcke U., Von Ammon K., Radu E. W., Leenders K. L., Sachsenheimer, W., Bimmler, T., Seiwald M., Eiter H. Rhomberg W., Ortler M., Obwegesser A., Kostron H., Steilen H., Henn W., Moringlane J. R., Kolles H., Feiden W., Zang K. D., Sleudel W. I., Steinbrecher, Andreas, Schabet, Martin, Heb, Clemens, Bamberg, Michael, Dichgans, Johannes, Stragliotto, G., Delattre, J. Y., Poisson, M., Zampieri, P., Brandes, A., Rigon, A., Tosatto, L., D'Amanzo, P., Menicucci, N., Rotilio, A., Mingrino, S., Steudel, W. I., Feld, R., Henn, W., Zang, K. D., Maire, J. Ph., Caudry, M., Guerin, J., Celerier, D., Salem, N., Demeaux, H., Fahregat, J. F., Kusak, M. E., Bucno, A., Albisua, J., Jerez, P., Sarasa, J. L., Garefa, R., de Campos, J. M., Kusak, M. E., de Campos, J. M., Bueno, A., García-Delgado, R., Sarasa, J. L., García-Sola, R., Lantsov A. A., Shustova T. I., Lcnartz, D., Wellenreuther, R., von Deirnling, A., Köning, W., Menzel, J., Scarpa, S., Manna, A., Reale, M. G., Oppido, P. A., Carapella, C. M., Frati, L., Valery, C. A., Ichen, M., Foncin, J. P., Soubrane, C., Khayat, D., Philippon, J., Vaz, R., Cruz, C., Weis S., Protopapa D., März R., Winkler P. A., Reulen H. J., Bise K., Beuls E., Berg J., Deinsberger, W., Böker, D. K., Samii, M., Caudry, M., Darrouzet, V., Guérin, J., Trouette, R., Causse, N., Bébéar, J. P., Parker, F., Vallee, J. N., Carlier, R., Zerah, M., Lacroix-Jousselin, C., Piepmeier, Joseph M., Kveton, John, Czibulka, Agnes, Tigliev G. S., Chernov M. P., Maslova L. N., Valdueza, José M., Jänisch, Werner, Bock, Alexander, Harms, Lutz, Bessell, E. M., Graus, F., Punt, J., Firth, J., Hope, T., Koriech, Osama, Al Deeb, Saleh, Al Moutaery, Khalaf, Yaqub, B., Silvani A., Salmaggi A., Pozzi A., Franzini A., Boiardi A., Goldbrunner, R., Warmuth-Metz, M., Paulus, W., Tonn, J. -Ch., Roosen, K., Strik I. I., Müller B., Markert C., Pflughaupt K. -W., Krauseneck P., O'Neill, B. P., Dinapoli, R. P., Voges, J., Sturm, V., Deuß, U., Traud, C., Treuer, H., Lehrke, R., Kim, D. G., Müller, R. P., Alexandrov Yu. S., Moutaery, K., Aabed, M., Koreich, O., Ross, G. M., Rajan, B., Traish, D., Ashley, S., Ford, D., Brada, M., Schmeets, I. L. O., Jager, J. J., Pannebakker, M. A. G., de Jong, J. M. A., van Lindert, E., Knosp, E., Kitz, K., Blond, S., Dubois, F., Assaker, R., Baranzelli, M. C., Sleiman, M., Pruvo, J. P., Coche-Dequeant, B., Matsutani M., Takakura K., Sano K., PetriČ-Grabnar, G., Jereb, B., Župančič, N., Koršič, M., Rainov N. G., Burkert W., Ushio, Yukitaka, Kochi, Masato, Itoyama, Youichi, de Campos, J. M., Kusak, M. E., Sarasa, J. L., García, R., Bueno, A., Ferrando, L., Hoang-Xuan, K., Sanson, M., Merel, P., Delattre, J. Y., Poisson, M., Delattre, O., Thomas, G., Hoang-Xuan, K., Delattre, J. Y., Poisson, M., Thomas, G., Haritz, D., Obersen, B., Grochulla, F., Gabel, D., Haselsberger K., Radner H., Pendl G., Brada, M., Laing, R. W., Warrington, A. P., Nowak, P. J. C. M., Kolkman-Deurloo, I. K. K., Visser, A. G., Berge, Hv. d., Niël, C. G. J. H., Levendag, P. C., Bergström P., Hariz M., Löfroth P. -O., Bergenheim T., Henriksson R., Blond, S., Assaker, R., Cortet-rudelli, C., Dewailly, D., Coche-dequeant, B., Castelain, B., Dinapoli, R., Shaw, E., Coffey, R., Earle, J., Foote, R., Schomberg, P., Gorman, D., Girard N., Courel M. N., Delpech B., Haselsberger K., Friehs G. M., Schröttner O., Pendl G., Pötter, R., hawliczek, R., Sperveslage, P., Prott, F. J., Wachter, S., Dieckmann, K., Würker, M., Herholz, K., Pietrzyk, U., Voges, J., Treuer, H., Sturm, V., Bauer, B., Heiss, W. -D., Jund, R., Zimmermann, F., Feldmann, H. J., Gross, M. W., Kneschaurek, P., Molls, M., Lederman, G., Lowry, J., Wertheim, S., Voulsinas, L., Fine, M., Lederman, G., Lowry, J., Wertheim, S., Fine, M., Voutsinas, I., Qian, G., Rashid, H., Lederman, G., Lowry, J., Wertheim, S., Fine, M., Voulsinas, L., Qian, G., Rashid, H., Moutaery, K., Aabed, M., Koreich, O., Scerrati M., Montemaggi P., Iacoangeli M., Pompucci A., Roselli R., Trignani R., Rossi G. F., Shin, K., Mechtler, L., West, C., Grand, W., Shin, K., Sibata, C., West, C., Mechtler, L., Grand, W., Thomas, R., Guerrero, D., James, N., Ashley, S., Gregor, A., Brada, M., Voges, J., Sturm, V., Bramer, R., Pahlke, H., Lehrke, R., Treuer, H., Banik, N., Kim, D. G., Hövels, M., Bernsen H. J. J. A., Rijken P. F. J. W., Van der Sanden B. P. J., Hagemeier N. E. M., Van der Kogel A. J., Koehler P. J., Verbiest H., Jager J., Vecht Ch. J., Ross G. M., McIlwrath A., Brown R., Mottolesb, C., Pierre'Kahn, A., Croux, M., Roche, J. L., Marchai, J., Delhemes, P., Tremoulet, M., Stilhart, B., Chazai, J., Caillaud, P., Ravon, R., Passacha, J., Bouffet, E., Dirven C. M. F., Mooy J. J. A., Molenaar W. M., Lewandowicz, G. M., Grant, N., Harkness, W., Hayward, R., Thomas, D. G. T., Darling, J. L., Delepine, N., Subovici I. I., Cornille B., Markowska S., Alkallaf JC. Desbois, KühI, J., Niethammer, D., Spaar, H. J., Gnekow, A., Havers, W., Berthold, F., Graf, N., Lampert, F., Maass, E., Mertens, R., Schöck, V., Aguzzi, A., Boukhny, A., Smirtukov, S., Prityko, A., Hoiodov, B., Geludkova, O., Nikanorov, A., Levin, P., Rothbart, David, Balledux, Jeroen, Criscuolo, Gregory R., D'haen, B., Van Calenbergh, F., Casaer, P., Dom, R., Menten, J., Goffin, J., Plets, C., Hertel, A., Hernaiz, P., Seipp, C., Siegler, K., Baum, R. P., Maul, F. D., Schwabe, D., Jacobi, G., Kornhuber, B., Hör, G., Menten, J., Casaer, P., Pilkington, G. J., Merzak, A., Rooprai, H. K., Bullock, P., van Domburg P. H. M. F., Wesseling P., Thijssen H. O. M., Wolff, J. E. A., Boos, J., Krähling, K. H., Gressner-Brocks, V., Jürgens, H., Schlegel, J., Scherthan, H., Arens, N., Stumm, Gabi, Kiessling, Marika, Merzak, A., Koochekpour, S., Pilkington, G. J., Reifenberger, G., Reifenberger, J., Liu, L., James, C. D., Wechsler, W., Collins, V. P., Fabel-Schulte, Klaus, Jachimczak, Plotr, Heßdörfer, Birgitt, Baur, Inge, Schlingensiepen, Karl -Hermann, Brysch, Wolgang, Bogdahn, Ulrich, Blesch A., Bosserhoff A. K., Apfel R., Lottspeich F., Jachimczak P., Büttner R., Bogdahn U., Cece, R., Barajon, I., Tazzari, S., Cavaletti, G., Torri-Tarelli, L., Tredici, G., Hecht, B., Turc-Carel, C., Atllas, R., Chatel, M., Gaudray, P., Gioanni, J., Hecht, F., Balledux, Jeroen, Rothbart, David, Criscuolo, Gregory R., de Campos, J. M., Kusak, M. E., Rey, J. A., Bello, M. J., Sarasa, J. L., Dubois, F., Blond, S., Parent, M., Assaker, R., Gosselin, P., Christiaens, J. L., Feld, R., Moringlane, J. R., Steudel, W. I., Schaudies, J. R., Janka M., Tonn J. C., Fischer U., Meese E., Roosen K., Remmelink, M., Salmon, I., Cras, P., Pasteels, J. L., Brotchi, J., Kiss, R., Bensadoun R. J., Frenay M., Formento J. L., Milano G., Lagrange J. L., Grellier P., Lee, J. -Y., Ernestus, R. -I., Riese, H. -H., Cervós-Navarro, J., Reutter, W., Lippitz, B., Scheitinger, C., Scholz, M., Weis, J., Gilsbach, J. M., Füzesi, L., Koochekpour, S., Merzak, A., Pilkington, G. J., Sanson, M., Li, Y. J., Hoang-Xuan, K., Delattre, J. Y., Poisson, M., Hamelin, R., Van de Kelft, Erik, Dams, Erna, Martin, Jean -Jacques, Willems, Patrick, Lehrke R., Voges J., Treuer H., Erdmann J., Müller R. P., Sturm V., Wurm R. E., Warrington A. P., Laing R. W., Sardell S., Hines F., Graham J. D., Brada M., Ushio, Yukitaka, Kuratsu, Jun -ichi, Kochi, Masato, Kitz K., Aichholzer M., Rössler K., Alesch F., Ertl A., Sorensen, P. S., Helweg-Larsen, S., Mourldsen, H., Hansen, H. H., El Sharoum, S. Y., Berfelo, M. W., Theunissen, P. H. M. H., Jager, J. J., de Jong, J. M. A., Fedorcsák, I., Nyáry, I., Osztie, É., Horvath, Á., Kontra, G., Frenay M., Burgoni-chuzel J., Paquis P., Lagrange J. L., Helweg-Larsen, S., Hansen, SW., Sørensen, PS., Salmon, I., Kiss, R., Krauseneck P., Müller B., Morche M., Tonn J. C., Lagerwaard, F. J., Levendag, P. C., Eijkenboom, W. M. H., Schmilz, P. I. M., Lentzsch S., Weber F., Franke J., Dörken B., Lunardi P., Schettini G., Osman Farah J., Qasho R., Mocellini, C., Ruda, R., Soffietti, R., Garabello, D., Sales, S., De Lucchi, R., Vasario, E., Schiffer, D., Muracciole, X., Régis, J., Manera, L., Peragut, J. C., Juin, P., Sedan, R., Nieder, C., Niewald, M., Walter, K., Schnabel, K., Nieder, C., Niewald, N., Nestle, U., Schnabel, K., Berberich, W., Oschmann, P., Theißen R. D., Reuner K. H., Kaps M., Dorndorf W., Martin, K. K., Akinwunmi, J., Rooprai, H. K., Kennedy, A., Linke, A., Ognjenovic, N., Pilkington, G. J., Svadovsky A. I., Peresedov V. V., Bulakov A. A., Butyalko M. Y., Zhirnova I. G., Labunsky D. A., Gnazdizky V. V., Gannushkina I. V., Taphoorn, M. J. B., Potman, R., Barkhof, F., Weerts, J. G., Karim, A. B. M. F., Heimans, J. J., van de Pol, M., van Aalst, V. C., Wilmink, J. T., Twijnstra, A., van der Sande, J. J., Boogerd, W., Kröger, R., Jäger A., Wismeth C., Dekant A., Brysch W., Schlingensiepen K. H., Jachimczak P., Bogdahn U., Pirolte, B., Cool, V., Gérard, C., Levivier, M., Dargent, J. L., Goldman, S., Brotchi, J., Hildebrand, J., Velu, T., Herrlinger, U., Schabet, M., Ohneseit, P., Buchholz, R., Zhu, Jianhong, Reszka, Regina, Weber, Friedrich, Walther, Wolfgang, Zhang, L. I., Brock, Mario, Roosen N., Rock J. P., Zeng H., Feng J., Fenstermacher J. D., Rosenblum M. L., Siegal, T., Gabizon, A., Beljanski M., Crochet S., Bergenheim, A. T., Zackrisson, B., Elfverson, J., Bergström, P., Henriksson, R., Butti, G., Baetta, R., Magrassi, L., De Renzis, M. R., Soma, M. R., Davegna, C., Pezzotta, S., Paoletti, R., Fumagalli, R., Infuso, L., Sankar, A. A., Darling, J. L., Thomas, D. G. T., Defer, G. -L., Brugières, P., Gray, F., Chomienne, C., Poirier, J., Degos, L., Degos, J. D., Colombo, Bruno M., DiDonato, Stefano, Finocchiaro, Gaetano, Hebeda, K. M., Sterenborg, H. J. C. M., Saarnak, A. E., Wolbers, J. G., van Gemert, M. J. C., Kaaijk P., Troost D., Leenstra S., Das P. K., Bosch D. A., Kostron H., Hochleitner B. W., Obwegeser A., Ortler M., Seiwald M., Vooys, W., Krouwer, H. G. J., de Gast, G. C., Marx, J. J. M., Osman Farah J., Lunardi P., Puzzilli F., Menovsky, T., Beek, J. F., Wolbers, J. G., van Gemert, M. J. C., Naujocks, G., Wiestler, O. D., Schirrmacher, V., Schramm, J., Schmitz, A., Eis-Hübinger, A. M., Piepmeier, p. h., Pedersen, Patricia, Greer, Charles, Quigley, Matthew R., Shih, Tommy, Elrifal, Amr, Rothfus, William, Maroon, Joseph C., Rohertson, L., Rampling, R., Whoteley, T. L., Piumb, J. A., Kerr, D. J., Falina, P. A., Crossan, I. M., Roosen N., Rock J. P., Feng J., Zeng H., Ho K. L., Fenstermacher J. D., Rosenblum M. L., Ruchoux, M. M., Vincent, S., Jonca, F., Plouet, J., Lecomte, M., Samid, D., Thibault, A., Ram, Z., Oldfield, E. H., Myers, C. E., Reed, E., Schabet, M., Herrlinger, U., Buchholz, R., Shoshan, Y., Siegal, T., Siegal, T., Shezen, E., Siegal, Tz., Stockhammer, G., Rosenblum, M., Samid, D., Lieberman, F., Terzis, A. J. A., Bjerkvig, R., Laerum, O. D., Arnold, H., Thibault, A., Samid, D., Figg, W. D., Myers, C. E., Reed, E., Thomas, R., Flux, G., Chittenden, S., Doshi, P., Brazil, L., Thomas, D. G. T., Bignor, D., Zalutsky, M., Brada, M., Tjuvajev, Juri, Kaplitt, Michael, Desai, Revathi, Bradley, M. S., Bettie B. S., Gansbacher, Bernd, Blasberg, Ronald, Haugland, H. K., Saraste, J., Rooseni, K., Laerum, O. D., Vincent, A. J. P. E., Avezaat, C. J. J., Bout, A., Noteboom, J. L., Vecht, C. h., Valerio, D., Hoogerbrugge, P. M., Weber, F., Reszka, R., Zhu, J., Walther, W., List, J., Schulz, W., Wolbers, J. G., Sterenborg, I. I. J. C. M., Kamphorst, W., van Gemert, M. J. C., van Alplien, H. A. M., Salander P., Bergenheim T., Henriksson R., Grant, R., Brazil, L., Thomas, R., Guerrero, D., Laing, R., Ashley, S., Brada, M., Schmidt B., Bauer B., Grau G., Bohnstedt, T., Frydrych A., Franz K., Lorenz R., Brandes, A., Amanzo, P. D'., Zampieri, P., Rigon, A., Scelzi, E., Rotilio, A., Berti, F., Paccagnella, A., Fiorentino, M. V., Müller B., Krauseneck P., van Deventer, P. L., Dellemijn, P. L. I., van den Bent, M. J., Vecht, Ch. J., Kansen, P. J., Tredici, G., Petruccioli, N. G., Cavaletti, G., Cavalletti, E., Kiburg, B., Müller, L. J., Moorer-van Delft, C. M., Heimans, J. J., Boer, H. H., Pace A., Bove L., Pietrangeli A., Innocenti P., Aloe A., Nardi M., Jandolo B., Kellie S. J., De Graaf S. S. N., Bloemhof H., Roebuck D., Dalla Pozza L., Uges D. D. R., Johnston I., Besser M., Chaseling R. A., Koeppen, S., Gründemann, S., Lossos, A., Siegal, T., Nitschke M., Vieregge P., Reusche E., Rob P., Kömpf D., Postma, T. J., Vermorken, J. B., Heimans, J. J., Rampling R. P., Dunlop D. J., Steward M. S., Campbell S. M., Roy S., Hilkens, P. H. E., Verweij, J., van Putten, W. L. J., Vecht, Ch. J., van den Bent, M. J., Hilkens, P. H. E., Moll, J. W. B., van der Burg, M. E. L., Planting, A. S. T., van Putten, W. L. J., Vecht, Ch. J., van den Bent, M. J., Wondrusch E., Zifko U., Drlicek M., Liszka U., Grisold W., Zifko U., Fazeny B., Dittrich Ch., Wondrusch E., Grisold W., Verschuuren, Jan J., Meneses, Patricio I., Rosenfeld, Myrna R., Kaplitt, Michael G., Posner, Jerome B., Dalmau, Josep, Sillevis Smitt P. A. E., Manley G., Posner J. B., Cavaletti, G., Bogliun, G., Margorati, L., Bianchi, G., Drlicek, M., Liska, U., Casati, B., Kolig, C., Grisold, H., Graus, F., Reñe, R., Uchuya, M., Valldeoriola, F., Delattre, J. Y., Benedetti de Cosentiro C., Ortale D., Martinez R., Lambre J., Cagnolati S., Vinai C., Salmaggi A., Nemni R., Silvani A., Forno M. G., Luksch R., Confalonieri P., Boiardi A., Nitschke M., Scholz J., Vieregge P., Kömpf D., Hochberg F. H., Pfeiffer, G., Netzer, J., Hansen, Ch., Eggers, Ch., Hagel Ch., Kunze, K., Verschuuren, Jan J., Rosenblum, Marc K., Lieberman, Frank S., Posner, Jerome B., and Dalmau, Josep

Published
1994
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11. Recurrent Oligodendroglioma Diagnosed with 11C-L-Methionine and PET: A Case Report

Author

P. Hubert, Jean-Michel Derlon, P. Courtheoux, J.P. Houtteville, F. Shishido, F. Viader, M.C. Petit-Taboué, and F. Chapon

Subjects
Pathology, medicine.medical_specialty, Methionine, medicine.diagnostic_test, business.industry, medicine.disease, nervous system diseases, chemistry.chemical_compound, Epilepsy, Neurology, chemistry, Positron emission tomography, Glioma, Medicine, Neurology (clinical), Oligodendroglioma, business, neoplasms, Intractable seizures
Abstract

A benign oligodendroglioma was removed in a young patient who had temporal epileptic seizures. He then became free of any fit until 15 months after the operation, when he developed seizures progressiv

Published
1993
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13. 900 MHz electromagnetic radiation effects on platinum intracranial implants

Author

F. Bureau, M. Tartire, and P. Courtheoux

Subjects
Tungsten filament, Materials science, chemistry, Electromagnetic coil, Cellular radio, chemistry.chemical_element, Implant, Tungsten, equipment and supplies, Platinum, Electromagnetic radiation, Biomedical engineering
Abstract

Intracranial aneurysms in surgically difficult locations are usually treated endovascularly. The treatment consists in the implantation of a tungsten or a platinum coil in the vein that is providing blood to the aneurysm sac. The implant is stopping the arrival of blood in the sac avoiding its rupture. Several articles have stated that in some cases, tungsten implants are severely damaged several months after the surgery and sometimes, they even completely disappear. As the phenomenon remained unexplained, tungsten implants were replaced by platinum implants but without more guarantees of success. The aim of this article is to check if we can expect platinum coils to be damaged like tungsten coils when implanted in the brain. As GSM mobile phone radiations have been suspected to contribute to the phenomenon, 900 MHz electromagnetic wave exposure of a tungsten and a platinum coil in a bloody environment have been reproduced. A corrosion of the tungsten filament was observed during the experiment while the platinum filament remained undamaged.

Published
2003
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14. [Endovascular treatment of a cervical vertebral artery pseudoaneurysm using covered stents. One case report]

Author

P, Courtheoux, J, Guarnieri, and J, Theron

Subjects
Adolescent, Coated Materials, Biocompatible, Humans, Female, Stents, Tomography, X-Ray Computed, Wounds, Nonpenetrating, Magnetic Resonance Imaging, Aneurysm, False, Vertebral Artery, Cerebral Angiography, Follow-Up Studies
Abstract

Covered stents have been successfully used in the treatment of fusiform aneurysms and post dissection aneurysms in peripheral arteries as well as in post-traumatic arteriovenous fistulas. We report a case where a pseudoaneurysm of the cervical vertebral artery was excluded by placement of two covered stents, preserving patency of the parent artery, in a 15-year-old patient.

Published
2003

17. [Management of vasospasm from subarachnoid hemorrhage. Attitude of French centers. French Society of Neuroradiology]

Author

S, Bracard, P, Arrue, F G, Barral, F, Bouquigny, J, Berge, J, Bonneville, A, Casasco, C, Cognard, P, Courtheoux, C, Depriester, J, Drouineau, G, Gozet, D, Herbreteau, E, Houdart, O, Levrier, D, Martin, J, Meder, J, Moret, A, Pasco-Papon, L, Pierot, G, Rodesch, F, Turjman, and A, Tournade

Subjects
Academic Medical Centers, Ischemic Attack, Transient, Humans, France, Subarachnoid Hemorrhage, Attitude to Health
Published
1999

19. Tumors of the optic nerve, eye and orbit

Author

L. Boiteau, Ch. Billote, and P. Courtheoux

Subjects
genetic structures, Optic canal, business.industry, Fibrous dysplasia, Meninges, Anatomy, medicine.disease, eye diseases, medicine.anatomical_structure, medicine, Optic nerve, sense organs, business, Superior ophthalmic vein, Orbit (anatomy)
Abstract

Due to its anatomical and histological composition, the orbit is an area where many tissues of different nature and origin are juxtaposed (bone, ocular globe, muscles, nerves, meninges, fat, vessels, lacrymal gland...). This diversity of tissue types is the reason for the multiplicity of disease processes encountered.

Published
1998
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20. Familial cavernous malformations in a large French kindred: mapping of the gene to the CCM1 locus on chromosome 7q

Author

B. Lechevalier, Françoise Chapon, J P Chodkiewicz, Katayoun Vahedi, M. T. Iba-Zizen, S. Khoury, J.P. Houtteville, P. Courtheoux, L. Notelet, E. A. Cabanis, and E. Tournier-Lasserve

Subjects
Adult, Intracranial Arteriovenous Malformations, Male, Adolescent, Genetic Linkage, Locus (genetics), Asymptomatic, Genetic linkage, medicine, Polymorphic Microsatellite Marker, Humans, Family, Chromosome 7 (human), Genetics, business.industry, Haplotype, Brain, Chromosome Mapping, Cavernous malformations, medicine.disease, Penetrance, Magnetic Resonance Imaging, Pedigree, Psychiatry and Mental health, Haplotypes, Papers, Surgery, Female, Neurology (clinical), France, medicine.symptom, Lod Score, business, Chromosomes, Human, Pair 7, Microsatellite Repeats
Abstract

Objectives—To characterise clinically a large French family aVected with cerebral cavernomas and to check for linkage of this condition to chromosome 7. Methods—A family,originating from Normandy and in which five members had undergone surgery for cavernomas, was extended. All members older than 18 were studied clinically and by neuroimaging. Genetic linkage analysis was conducted using 11 polymorphic microsatellite markers located between D7S502 and D7S479. Results—The family included three generations. Among the 25 members investigated, 11 had an abnormal cerebral MRI, eight of them being symptomatic, and 12 were asymptomatic with a normal MRI. The status of the two remaining members could not be established on the basis of clinical and MRI data. The family reported shares some striking features with other previously linked families—namely, a high clinical penetrance and the presence of multiple lesions within most of the aVected members. A lod score of 4.04 was obtained with marker D7S657 with no recombinant. Significant lod scores were also obtained with D7S524 (Zmax=3.32 at =0.00) and D7S630 (Zmax=3.44 at =0.00). These results establish linkage of the condition found in this family to chromosome 7. Haplotype analysis strongly suggests that the gene is telomeric to D7S802 and centromeric to D7S479. Conclusions—These data confirm linkage of cerebral cavernous malformations to chromosome 7 in a non-Hispanic family. (J Neurol Neurosurg Psychiatry 1997;63:40‐45)

Published
1997

21. [Topographical diagnosis of insulinoma of the pancreas. Value of the test of intra-arterial calcium infusion]

Author

Y, Reznik, C, Coffin, P, Courtheoux, A, Schletzer-Mari, D, Roland-Billecart, and J, Mahoudeau

Subjects
Adult, Male, Pancreatic Neoplasms, Angiography, Humans, Infusions, Intra-Arterial, Insulin, Calcium, Female, Insulinoma, Stimulation, Chemical, Aged
Abstract

The localization of insulinomas is a central problem, because none of the imaging techniques has proved sufficiently reliable for the diagnosis of tumors smaller than 2 cms.Calcium stimulation test was performed during selective pancreatic angiogram with calcium gluconate injection in the pancreatic arteries, e.g. gastroduodenal, superior mesenteric and splenic. A simultaneous catheterization of hepatic veins through the femoral vein allowed measurement of insulin level increment after calcium stimulation.In our experience, this test allowed a positive location of an insulinoma in three consecutive patients presenting with organic hypoglycemia, and was useful for surgeons while non-invasive imaging techniques failed to locate the tumor in any of the three patients.The calcium stimulation test is a reliable preoperative procedure, particularly when other imaging techniques fail to locate the tumor. However it remains invasive, and our data are still too preliminary to clearly define its place within imaging techniques.

Published
1997

22. [Dural fistulae of the cavernous sinus and interventional neuroradiology. Apropos of 4 cases]

Author

P, Prigent, P, Courtheoux, P, Le Coq, A, Le Callonnec, and M, Urvoy

Subjects
Aged, 80 and over, Arteriovenous Fistula, Neuroradiography, Humans, Cavernous Sinus, Female, Dura Mater, Middle Aged, Radiography, Interventional, Embolization, Therapeutic, Aged
Abstract

Our purpose was to show how difficult it is to diagnose a dural fistula of the cavernous sinus, which is an anomalous arteriovenous shunt within the dura mater extending from meningeal arteries to the cavernous sinus.A dural fistula was suspected in four female patients aged between 61 and 80, presenting with a red eye, dilated episcleral veins, exophthalmos and elevated intraocular pressure. A cerebral hyperselective angiography was performed in all cases.The cerebral angiography confirmed the diagnosis of a dural fistula in all cases, showing the early filling of the cavernous sinus followed by the draining vessel (posterior in case n. 4, anterior in cases n degrees 1, 2, 3). Case n degrees 2 was unilateral and cases n. 1, 3, 3 were bilateral. The blood flow was low in all cases. A successful embolization was performed in all patients with resolution of all symptoms.The diagnosis of dural fistulas is often difficult because of misleading clinical signs. It is documented by a cerebral angiography showing the feeding vessels and helping to choose either venous or arterial embolization which is the most suitable treatment.

Published
1996

23. [Dural fistula of the cavernous sinus. Treatment through an intravenous approach apropos of 4 cases]

Author

P, Courtheoux, H, Huet, A, Tournade, and J, Theron

Subjects
Aged, 80 and over, Meninges, Arteriovenous Fistula, Carotid Artery, External, Humans, Cavernous Sinus, Female, Dura Mater, Middle Aged, Embolization, Therapeutic, Carotid Artery, Internal, Aged, Veins
Abstract

The authors report 4 cases of symptomatic dural fistula of the carotid cavernous sinus treated by transvenous coils. The objectives of dural fistula treatment are now clearly established and several methods are available. Abstention is the rule for asymptomatic forms, whereas symptomatic forms with ophthalmological complications may respond to manual compression of the jugular vein and the carotid artery, arterial embolization, radiotherapy or venous embolization. Arterial embolization results in complete cure in 72% to 78% of the cases, but it is limited by the meningeal supply of the internal carotid artery, with the microcatheter the transvenous route make it possible to treat the meningeal supply from the internal and external carotids without affecting the arterial system, but this technique is restricted by the anatomy of each patient.

Published
1995

25. Recurrent oligodendroglioma diagnosed with 11C-L-methionine and PET: a case report

Author

F, Viader, J M, Derlon, M C, Petit-Taboué, F, Shishido, P, Hubert, J P, Houtteville, P, Courtheoux, and F, Chapon

Subjects
Male, Reoperation, Adolescent, Brain Neoplasms, Oligodendroglioma, Diagnosis, Differential, Methionine, Postoperative Complications, Epilepsy, Temporal Lobe, Humans, Carbon Radioisotopes, Neoplasm Recurrence, Local, Follow-Up Studies, Tomography, Emission-Computed
Abstract

A benign oligodendroglioma was removed in a young patient who had temporal epileptic seizures. He then became free of any fit until 15 months after the operation, when he developed seizures progressively less controlled by therapy. All investigations were normal (including CT scan and MRI) except a PET study which showed a high uptake of 11C-L-methionine in the area of the previous tumor. The second operation revealed that this area was indeed a tumor recurrence. We briefly discuss the potential usefulness of PET for the follow-up of low grade gliomas.

Published
1993

26. Regional cerebral oxygen consumption, blood flow, and blood volume in healthy human aging

Author

Giuliano Sette, J.-M. Travere, Gilles Marchal, C. Le Poec, P. Courtheoux, Patrice Rioux, Jean-Claude Baron, J M Derlon, and M.C. Petit-Taboué

Subjects
Adult, Male, medicine.medical_specialty, Aging, Hemodynamics, Blood volume, Hematocrit, White matter, Oxygen Consumption, Arts and Humanities (miscellaneous), Internal medicine, medicine, Humans, Radionuclide Imaging, Aged, Blood Volume, medicine.diagnostic_test, business.industry, Brain, Blood flow, Middle Aged, medicine.anatomical_structure, Blood pressure, Cerebral blood flow, Cerebral cortex, Anesthesia, Cerebrovascular Circulation, Cardiology, Female, Neurology (clinical), business
Abstract

• Using high-resolution positron emission tomography and the oxygen 15 continuous inhalation method, we examined the changes in cerebral metabolic rate of oxygen, blood flow, blood volume, and oxygen extraction fraction as a function of age in 25 optimally healthy, unmedicated volunteers who ranged in age from 20 to 68 years. Subjects were strictly selected for absence of cerebrovascular risk factors, dementia, or mental disorders; they had neither biological nor clinical abnormalities, and no focal anomaly on computed tomographic scan. Regions of interest were determined according to the anatomical structures defined on corresponding computed tomographic scan cuts obtained using a stereotaxic head-positioning method. This same method was also used for positron emission tomographic imaging. There was no significant effect of aging on Paco 2 values, hematocrit, arterial blood pressure, cholesterol and triglyceride levels, and blood glucose levels. In most cerebral cortex gyri, the cerebral metabolic rate of oxygen significantly decreased with age according to a linear pattern, with the same magnitude (about -6% per decade) in all four lobes and on both sides. This effect of age on cortical cerebral metabolic rate of oxygen persisted when the possible influence of cortical atrophy, gender, and head size were partialled out. In contrast, the white matter, deep gray nuclei, thalamus, and cerebellum were not significantly affected. The cerebral blood volume declined with a similar pattern to cerebral metabolic rate of oxygen, while changes in cerebral blood flow were less significant, presumably because of larger variance of data across subjects. Aging left the cerebral blood flow—cerebral blood volume—cerebral metabolic rate of oxygen coupling unaltered, as shown by lack of changes in both the oxygen extraction fraction and the cerebral blood flow—cerebral blood volume ratio. The selective decrease of oxygen metabolism in neocortex during normal aging could result from the combined effects of direct neuronal loss, cellular biological impairment, and functional deafferentation, and could underlie or reflect age-related cognitive changes.

Published
1992

27. [Embolization in venous erectile insufficiency]

Author

P, Courtheoux

Subjects
Adult, Male, Erectile Dysfunction, Humans, Middle Aged, Embolization, Therapeutic, Aged, Penis
Abstract

The authors report their experience with management of venous erectile insufficiency. The patients were classified according to radiologic criteria. 46 patients with venous insufficiency of the Santorini plexus were treated by detachable balloons and coils with 57% of satisfactory clinical results.

Published
1991

28. New triple coaxial catheter system for carotid angioplasty with cerebral protection

Author

J, Theron, P, Courtheoux, F, Alachkar, G, Bouvard, and D, Maiza

Subjects
Carotid Artery Diseases, Male, Arterial Occlusive Diseases, Middle Aged, Brain Ischemia, Cerebral Angiography, Cerebrovascular Circulation, Catheterization, Peripheral, Journal Article, Humans, Female, Angioplasty, Balloon, Carotid Artery, Internal, Aged
Published
1990

29. CO-18 Suivi à un an des sténoses athéromateuses intra-crâniennes du système vertébro-basilaire traitées par stent

Author

J. Theron and P. Courtheoux

Subjects
Radiological and Ultrasound Technology, Radiology, Nuclear Medicine and imaging, Neurology (clinical)
Abstract

Objectifs Analyse des resultats cliniques et angiographiques a 1 an des stenoses atheromateuses symptomatiques du systeme vertebrobasilaire intra-crânien traitees par stent. Materiels et Methodes 18 patients ont ete revus a 1 an pour exploration clinique et angiographique apres stenting d’une stenose atheromateuse vertebrobasilaire. Resultats 1 patient est decede par thrombose du tronc basilaire liee a un non-respect du traitement anti-plaquettaire. 2 patients ont vu leur symptomatologie clinique re-apparaitre avec re-stenose angiographique. 1 patient a thrombose son stent au niveau du tiers inferieur du tronc basilaire, sans aucune symptomatologie clinique.14 patients sont restes asymptomatiques a un an, sans re-stenose significative au sein du stent. Conclusion Le stenting des stenoses symptomatiques vertebro-iliaques intra-crâniennes apparait efficace sur la symptomatologie clinique. Le taux de re-stenose a un an reste faible. Il est a noter qu’aucune re-stenose n’a ete re-dilatee.

Published
2004
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30. P-14 Traitement des anévrysmes intra- crâniens par coïls matrix

Author

P. Courtheoux and J. Theron

Subjects
Radiological and Ultrasound Technology, Radiology, Nuclear Medicine and imaging, Neurology (clinical)
Abstract

Objectifs Analyse des premiers resultats de l’utilisation des coils Matrix dans le traitement des anevrysmes intra-cerebraux. Materiels et Methodes 12 patients (13 anevrysmes) ont ete embolises par coils Matrix de mai 2003 a novembre 2003 (71 patients ont ete traites durant la meme periode par coils standards). 6 anevrysmes ont ete embolises en urgence pour hemorragie meningee. Dans 4 autres cas, il s’agissait d’une reprise pour compaction apres un traitement par coils standards et dans 3 autres cas, d’anevrysmes non rompus. Tous les anevrysmes de cette serie avaient un diametre maximum inferieur a 12 mm et un ration sac/collet favorable. Resultats Aucune complication en per et post embolisation n’a ete a deplorer. Les controles angiographiques a 24 h ont montre, dans deux cas, deux castes immediats imparfaits, une exclusion complete du sac anevrysmal. Les controles angiographiques a 6 mois n’ont pas montre de recidive ou de compaction, notamment chez les patients re-embolises pour compaction apres traitement par coils standards. Conclusion L’utilisation des coils Matrix apparait plus difficile que celle des coils traditionnels, du fait de friction lors de la poussee au sein du micro-catheter et de la formation de logettes dans le sac anevrysmal. Toutefois, les resultats semblent prometteur mais demandent un « follow-up » plus long.

Published
2004
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31. Proton magnetic resonance spectroscopy and schizophrenia

Author

J Fernandez, Pascal Delamillieure, P. Brazol, T. Vasse, J M Constans, P. Courtheoux, Sonia Dollfus, and Michel Petit

Subjects
Psychiatry and Mental health, Relaxometry, Materials science, Nuclear magnetic resonance, Solid-state nuclear magnetic resonance, Schizophrenia (object-oriented programming), Spin echo, Spectroscopy, Biological Psychiatry, Proton magnetic resonance
Published
1998
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33. Stent placement in superior vena cava syndrome.

Author

Courtheoux, Patrick, Alkofer, Barbara, Al Refaï, Madjed, Gervais, Radj, Le Rochais, Jean Philippe, and Icard, Philippe

Subjects
VENA cava superior, SYNDROMES, CHEST diseases, SYMPTOMS
Abstract

: BackgroundSuperior vena cava syndrome (SVCS) is often seen in the natural history of malignant thoracic diseases. SVCS is characterized by unpleasant symptoms that usually lead to death. The purpose of our study is to show the efficiency of percutaneous stenting in the superior vena cava for relieving SVCS and the possibility of repeated stenting after recurrence.: MethodsTwenty patients with SVCS caused by malignant diseases who had one or more stents placed in the superior vena cava or its main tributaries were evaluated.: ResultsOut of 20 patients, 1 died of myocardial infarction 24 hours after the procedure without any signs of pulmonary embolus, hemorrhage, or malposition of the stent. SVCS was successfully controlled in 94% of patients until death or completion of the study. In 3 patients the procedure was repeated (3 to 20 weeks later) because of the recurrence of symptoms.: ConclusionsPercutaneous venous stent placement in the superior vena cava is a simple and effective technique to relieve rapid SVCS caused by malignancies. When recurrence occurs, repeated stenting can be performed successfully. [Copyright &y& Elsevier]

Published
2003
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35. Radial Approach in the Treatment of Supraaortic Arterial Lesions

Author

Théron, J., Guimaraens, L., Casasco, A., Sola, T., Saleme, S., Courtheoux, P., and Hamon, M.

Abstract

Radial approach (mainly right) has been used in the treatment of 67 supraaortic lesions including 56 carotid, nine vertebral and two subclavian artery stenoses. This approach offers new possibilities and solves most of the remaining technical difficulties or impossibilities encountered in the endovascular treatment of supraaortic lesions. The current technique is described. The results of this first series have been very satisfactory without complication. MR angiography allows selection of patients suitable for radial approach.

Published
2007
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36. Cerebral Microembolism During Cardiac Catheterization and Risk of Acute Brain Injury

Author

Hamon, Michèle, Gomes, Sophie, Oppenheim, Catherine, Morello, Rémy, Sabatier, Rémi, Lognoné, Thérèse, Grollier, Gilles, Courtheoux, Patrick, and Hamon, Martial

Abstract

Cerebral microembolism detected by transcranial Doppler occurs systematically during cardiac catheterization, but its clinical relevance remains unknown. Studies suggest that asymptomatic embolic cerebral infarction detectable by diffusion-weighted (DW) MRI might exist after percutaneous cardiac interventions, especially after retrograde catheterization of the aortic valve in patients with valvular aortic stenosis, with a frequency as high as 22% of cases. We investigated the incidence of new ischemic lesions on serial cerebral DW MRI after cardiac catheterization.

Published
2006
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37. Modelling multichannel response behaviour

Author

Courtheoux, Richard J

Abstract

For most organisations, the marketing realities of the 21st century include both stimulating demand through multiple media and capturing demand through multiple channels. To build models that provide a solid basis for customer segmentation and marketing contact decisions, marketers must be able to isolate and predict the incremental impact of each contact. This paper discusses recommended procedures for diagnosing the structure of the marketing situation with respect to multiple interacting channels and the subsequent appropriate choices of models that should be created. It also explores issues related to the accurate creation of behavioural (dependent) and predictive (independent) variables as a key modelling success factor in a multichannel marketing environment.

Published
2003
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38. “Protected” Wallstenting of Atheromatous Stenoses at the Carotid Bifurcation

Author

Théron, J.G., Guimaraens, L.J., Casasco, A.E., Courtheoux, P.G., Beaujeux, R.L., Rufenacht, D.A., Coskun, O., Sola, M.T., Constans, J.-M., and Martin, J.-B.

Abstract

Atheromatous stenoses at the carotid bifurcation were treated by angioplasty and Wallstenting with cerebral protection obtained in most cases by temporary occlusion of the internal carotid artery. 287 carotid stenoses were treated in 233 patients. The stenosis was symptomatic in 79% of cases. All patients presented either a stenosis of >70% with significant impairment of the cerebral circulation (281 cases) or a symptomatic ulcerated plaque (six cases). A self-mounted protection system was used in 177 cases, the Percusurge Guardwire protection device in 98 cases an EPI filter in 12 cases. There was a contralateral internal carotid occlusion in 13% of cases. A combined stenting (vertebral, siphon, subclavian) was performed in 14% of cases. A Rolling membrane Wallstent was used in 84 patients, a first generation Easy Wallstent in 38 cases, a “Carotid” Easy Wallstent 35 in 55 cases and monorail 14 in 110 cases.Full opening of the stenosis was obtained in 98% of patients with correction of the arterial curve and improvement of the cerebral vascular supply. There were 0.7% cases with transient symptomatic neurological complications and 2% with permanent sequelae mainly related to avoidable inadequacy in flushing or to the insufficient radial force of the first generation Easy Wallstent. There were no per and one post-procedural cardiac complication (0.6%) in the s165 cases performed with the “Carotid” Easy Wallstent. Follow-up angiograms showed O.7% of restenoses. Still in evolution, endovascular treatment of atheromatous stenoses at the carotid bifurcation with cerebral protection and stenting is a promising alternative technique to surgery. The association of Carotid Easy Wallstent 14 monorail and Percusurge Guardwire appears to be currently satisfactory.

Published
2003
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39. Database marketing connects to the Internet

Author

Courtheoux, R J

Abstract

Long before the advent of the commercial Internet in the late 1990s, the concept of database marketing pushed forward a revolution in marketing. Leading marketers struggled with the implications of three key database marketing concepts: — individual, addressable customers are the central focus of marketing — customer data can be collected, analysed and then used to drive marketing — customer management should be long-term oriented. As a result, marketing processes were re-engineered, a more technical cadre of professionals joined marketing departments, software products were created and new types of service businesses emerged. This first generation of database marketing emerged when computer technology could support three important functions. — Very large-scale collection of customer data, especially transactional data, from multiple sources. Computerisation of operations reached the point where virtually every customer interaction resulted in a digital trail that could be linked to a customer master record. — Affordable retention and processing of marketing databases. Marketing databases often contain millions of customers and tens of millions of related records in order to be effective drivers of marketing programmes. To a large degree, the requirements of database marketing forced the creation of online databases in place of tape-based, offline files. — Analysis and access tools that enabled decision support and statistical modelling and targeting of marketing communications. These provided the business pay-off needed to justify investments in database building. Many experts quite appropriately called the infusion of both concepts and technology into the marketing realm ‘revolutionary’. However, by the beginning of the new millennium this revolution became an accepted, even everyday, component of corporate marketing. Given the force, speed and trajectory of today's Internet-driven changes in marketing, it might be more appropriate to call this a hyper-revolution. Whenever change happens so dramatically, it is easy get both immersed and lost in the details of what is occurring. This paper attempts to show the connections between Internet-driven changes in marketing practice and the earlier foundation of database marketing.

Published
2000
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40. FMRI and PET of Self-Paced Finger Movement: Comparison of Intersubject Stereotaxic Averaged Data

Author

Joliot, Marc, Papathanassiou, Dimitri, Mellet, Emmanuel, Quinton, Olivier, Mazoyer, Nathalie, Courtheoux, Patrick, and Mazoyer, Bernard

Abstract

We compared the intersubject-averaged functional anatomy of self-paced right index finger movement as revealed by 15O water positron emission tomography (PET) and blood oxygen level-dependent functional magnetic resonance imaging (FMRI) at 1.5 T. Image data sets were acquired with both techniques on a group of eight subjects, spatially normalized in the stereotaxic space and subsequently processed in order to get identical smoothness and degrees of freedom. Intersubject-averaged PET and FMRI activation maps were found congruent in the left primary sensorimotor area (PSM), bilateral supplementary motor area, bilateral supra marginalis gyri, left operculum, left inferior parietal lobule, right middle frontal gyrus, and right cerebellum. In those regions the mean distance between PET and FMRI local maxima was 7.4 mm. FMRI detected additional activations in the right precentral gyrus, right rolandic operculum, right inferior parietal lobule, and bilateral insula, whereas PET demonstrated a higher detection sensitivity at the deep nuclei level. PET and FMRI percentage signal variations were found linearly related by a factor around 10, both within the PSM and across a set of distributed local extrema. However, in most cases, FMRI was more sensitive than PET, as assessed by tvalues. Finally the pattern of deactivations was markedly dissimilar between the two techniques, possibly due to differences in the “Rest” control task.

Published
1999
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41. Regional Cerebral Oxygen Consumption, Blood Flow, and Blood Volume in Healthy Human Aging

Author

Marchal, Gilles, Rioux, Patrice, Petit-Taboué, Marie-Christine, Sette, Giuliano, Travère, Jean-Marcel, Le Poec, Claude, Courtheoux, Patrick, Derlon, Jean-Michel, and Baron, Jean-Claude

Abstract

• Using high-resolution positron emission tomography and the oxygen 15 continuous inhalation method, we examined the changes in cerebral metabolic rate of oxygen, blood flow, blood volume, and oxygen extraction fraction as a function of age in 25 optimally healthy, unmedicated volunteers who ranged in age from 20 to 68 years. Subjects were strictly selected for absence of cerebrovascular risk factors, dementia, or mental disorders; they had neither biological nor clinical abnormalities, and no focal anomaly on computed tomographic scan. Regions of interest were determined according to the anatomical structures defined on corresponding computed tomographic scan cuts obtained using a stereotaxic head-positioning method. This same method was also used for positron emission tomographic imaging. There was no significant effect of aging on Paco2 values, hematocrit, arterial blood pressure, cholesterol and triglyceride levels, and blood glucose levels. In most cerebral cortex gyri, the cerebral metabolic rate of oxygen significantly decreased with age according to a linear pattern, with the same magnitude (about -6% per decade) in all four lobes and on both sides. This effect of age on cortical cerebral metabolic rate of oxygen persisted when the possible influence of cortical atrophy, gender, and head size were partialled out. In contrast, the white matter, deep gray nuclei, thalamus, and cerebellum were not significantly affected. The cerebral blood volume declined with a similar pattern to cerebral metabolic rate of oxygen, while changes in cerebral blood flow were less significant, presumably because of larger variance of data across subjects. Aging left the cerebral blood flow—cerebral blood volume—cerebral metabolic rate of oxygen coupling unaltered, as shown by lack of changes in both the oxygen extraction fraction and the cerebral blood flow—cerebral blood volume ratio. The selective decrease of oxygen metabolism in neocortex during normal aging could result from the combined effects of direct neuronal loss, cellular biological impairment, and functional deafferentation, and could underlie or reflect age-related cognitive changes.

Published
1992
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43. Familial cavernous malformations in a large French kindred: mapping of the gene to the CCM1 locus on chromosome 7q

Author

Iba-Zizen, M.T., Notelet, L., Cabanis, E.A., Chapon, F., Lechevalier, B., Vahedi, K., Tournier-Lasserve, E., Khoury, S., Houtteville, J.P., Chodkiewicz, J.P., and Courtheoux, P.

Abstract

Objectives To characterise clinically a large French family affected with cerebral cavernomas and to check for linkage of this condition to chromosome 7. Methods A family, originating from Normandy and in which five members had undergone surgery for cavernomas, was extended. All members older than 18 were studied clinically and by neuroimaging. Genetic linkage analysis was conducted using 11 polymorphic microsatellite markers located between D7S502 and D7S479. Results The family included three generations. Among the 25 members investigated, 11 had an abnormal cerebral MRI, eight of them being symptomatic, and 12 were asymptomatic with a normal MRI. The status of the two remaining members could not be established on the basis of clinical and MRI data. The family reported shares some striking features with other previously linked families--namely, a high clinical penetrance and the presence of multiple lesions within most of the affected members. A lod score of 4.04 was obtained with marker D7S657 with no recombinant. Significant lod scores were also obtained with D7S524 (Zmax=3.32 at θ=0.00) and D7S630 (Zmax=3.44 at θ=0.00). These results establish linkage of the condition found in this family to chromosome 7. Haplotype analysis strongly suggests that the gene is telomeric to D7S802 and centromeric to D7S479. Conclusions These data confirm linkage of cerebral cavernous malformations to chromosome 7 in a non-Hispanic family.

Published
1997

45. Chemoembolization of lumbar spine metastases. A preliminary study

Author

P, Courtheoux, F, Alachkar, A, Casasco, Y, Adam, J M, Derlon, F, Courtheoux, J L, L'Hirondel, and J, Theron

Subjects
Adult, Male, Radiography, Spinal Neoplasms, Mitomycin, Humans, Female, Middle Aged, Embolization, Therapeutic, Aged, Mitomycins
Published
1985

46. [Hemodynamic study of obstructive lesions of the internal carotid artery: value of coupled measurement of regional cerebral blood flow and volume]

Author

J M, Derlon, G, Bouvard, P, Hubert, B, Lechevalier, B, Dupuy, F, Viader, D, Maiza, P, Courtheoux, Y, Fernandez, and J P, Houtteville

Subjects
Carotid Artery Diseases, Cerebral Revascularization, Ischemic Attack, Transient, Regional Blood Flow, Hemodynamics, Brain, Humans, Arterial Occlusive Diseases, Carotid Artery, Internal, Xenon Radioisotopes, Brain Ischemia, Tomography, Emission-Computed
Abstract

A study of 130 patients having presented either a transient ischemic attack or a completed stroke, or admitted for an asymptomatic carotid stenosis, allowed the following investigations: CT-scan, doppler, angiography, measurement of the regional cerebral blood flow (rCBF) by the study of 133Xe clearance (Novocerebrograph (R)), and measurement of the regional cerebral blood volume (rCBV) made by gamma emission tomography after autotransfusion of 99m Tc-labeled erythrocytes with an Elscint Apex 415 ECT (R) camera. Our aim was to look in which case a rCBF and/or a rCBV interhemispheric asymmetry was observed, by comparing the previous hemodynamic parameters with clinical, CT-scan and angiographic data. Although a rCBF and/or a rCBV asymmetry appeared more often among patients presenting with infarction than among those of the asymptomatic category, this does not seem specific for any clinical grade. The same statement applies to the comparison between hemodynamic parameters and CT data. The arterial lesions were classified in 4 groups: no stenosis (12 cases), uni or bilateral moderate carotid stenosis (40 cases), unilateral severe carotid stenosis or occlusion (65 cases), bilateral carotid severe stenosis or occlusion (13 cases). We observed a rCBF asymmetry among some patients in the 4 groups, although this was more frequent among the two latter groups. Nevertheless no case of a rCBV asymmetry was observed in the 2 first groups. Such an asymmetry was present in 31 percent of the patients belonging to the two latter groups. In patients of the third group the asymmetry was always due to a relative increase of rCBV beyond the carotid lesion.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1987

47. [Primary meningioma of the maxillary sinus. Apropos of a case]

Author

C, Postel, B, Sautreuil, J, Mani, P, Courtheoux, A, Valdazo, and J, Theron

Subjects
Maxillary Sinus Neoplasms, Humans, Female, Middle Aged, Meningioma, Tomography, X-Ray Computed, Paranasal Sinus Neoplasms
Abstract

A case report concerning a left primary maxillary meningioma is presented. Clinical, conventional radiographic and CT signs are presented. The diagnosis was made after histologic examination of the specimen. The pathogenesis is discussed.

Published
1987

48. [Granular cell tumor of a cerebral hemisphere: value of gliofibrillary protein acid assay]

Author

B, Lechevalier, J C, Mandard, Y, Adam, D C, Da Silva, C, Bazin, and P, Courtheoux

Subjects
Immunoenzyme Techniques, Male, Microscopy, Electron, Intermediate Filament Proteins, Brain Neoplasms, Parietal Lobe, Glial Fibrillary Acidic Protein, Humans, Occipital Lobe, Middle Aged
Abstract

A patient with a left parieto-occipital tumor presented generalized convulsions, and aphasia with alexia and agraphia. Diagnosis was confirmed by CT scan. Partial excision only was possible and was followed by radiotherapy. Histology showed the tumor to be composed of moderate and large sized cells with a granular PAS+ cytoplasm. Protoplasmic astrocytes were numerous at the periphery. Electron microscopy demonstrated typical features of Abrikossof's granular cell tumor: heterogeneous granulations constituted mainly of secondary lysosomes, autophagic vacuoles, multivesicular bodies, and rare angular bodies. The granular cells were interspersed with astrocytes, the feet of which were implanted on the capillary basal membrane. Immunoperoxidases assay of gliofibrillary protein acid demonstrated high levels in the intercellular prolongations, considered here to be astrocytic, but weak concentrations in the granular cells. This suggests uptake by the latter cells of adjacent astrocytic gliofibrillary protein acid, especially as the action of an anti-albumin serum on the tumor demonstrated that the granular cells can take up extracellular proteins by a passive mechanism. These findings stand against an astrocytic origin of the tumor. Comparison with other granular cell tumors, particularly pituicytomas, provides evidence of morphological unity, but cerebral granular cell tumors are rich in astrocytes, whereas these are absent in pituicytomas. The oncogenic unity of these tumors has not been established.

Published
1982

49. Local intraarterial fibrinolysis in the carotid territory

Author

J, Theron, P, Courtheoux, A, Casasco, F, Alachkar, F, Notari, F, Ganem, and D, Maiza

Subjects
Adult, Aged, 80 and over, Carotid Artery Diseases, Male, Arterial Occlusive Diseases, Case Reports, Middle Aged, Urokinase-Type Plasminogen Activator, Fibrinolytic Agents, Injections, Intra-Arterial, Humans, Female, Streptokinase, Cerebral Arterial Diseases, Aged
Abstract

A series comprising 12 patients who had intraarterial local fibrinolysis in the carotid territory is reported. A classification is proposed that divides the different types of occlusions into three groups on the basis of angiographic location. Group 1 (two cases) comprises occlusion of the extra- and/or intracranial carotid artery with patency of the circle of Willis and the lenticulostriate arteries. In this group, there is no brain infarction, the CT findings are normal, and the clinical signs are mainly hemodynamic and intermittent. Fibrinolysis may be performed late and rather safely and completed by surgery or angioplasty of the neck vessel stenosis responsible for the occlusion. Group 2 (five cases) comprises occlusions of the cortical arteries without involvement of the lenticulostriate arteries. The mechanism of the occlusion can be hemodynamic or embolic. Group 3 (five cases) comprises occlusions of intracerebral arteries involving the lenticulostriate arteries. In groups 2 and 3 with brain infarction, fibrinolysis will only be able to restore viability of the area of cerebral tissue surrounding the infarction (penumbra). The time factor is particularly critical in group 3 because lenticulostriate arteries are terminal vessels whose revascularization may induce hemorrhages with increasing frequency as the occlusion time is prolonged. The time factor is less critical in group 2 because collaterals make the ischemia less severe in the infarcted area and the vital and functional consequences of hemorrhage are not as serious as in group 3 because of the location. In this series, all the symptomatic complications of hemorrhage (two cases) occurred in group 3, in patients treated later than 6 hr after clinical onset. Given the time delay inherent in performing CT and angiography and in making the medical decision, it is considered dangerous to undertake fibrinolytic therapy in group 3, unless it can be started before 4 or 5 hr after clinical onset.

Published
1989

50. [Acute cardiac liver following a pulmonary embolism. Apropos of 2 cases]

Author

J P, Brandel, P, Commeau, G, Grollier, P, Charbonneau, C, Breut, P, Courtheoux, B, Le Chevalier, and J C, Potier

Subjects
Male, Heart Diseases, Liver Diseases, Acute Disease, Humans, Middle Aged, Pulmonary Embolism
Abstract

The authors report 2 cases of acute hepatic failure secondary to a pulmonary embolism, the [atypical] symptomatology of which considerably interfered with diagnosis. A review of the literature confirms the rarity of embolic pathology as causing acute cardiac liver. The authors emphasize the importance of echotomography (cardiac and abdominal) in seeking dilatation of the right heart cavities, as well as of the inferior vena cava and hepatic veins.

Published
1985

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