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6. Refraction-Based Speed of Sound Estimation in Layered Media: An Angular Approach

Author

Heriard-Dubreuil, Baptiste, Besson, Adrien, Wintzenrieth, Frederic, Cohen-Bacrie, Claude, and Thiran, Jean-Philippe

Abstract

Speed of sound estimation in ultrasound imaging is a growing modality with several clinical applications such as hepatic steatosis stages quantification. A key challenge for clinically relevant speed of sound estimation is to obtain repeatable values independent of superficial tissues and available in real-time. Recent works have demonstrated the feasibility to achieve quantitative estimations of the local speed of sound in layered media. However, such techniques require high computational power and exhibit instabilities. We present a novel speed of sound estimation technique based on an angular approach of ultrasound imaging in which plane waves are considered in transmit and receive. This change of paradigm allows us to rely on the refraction properties of plane waves to infer the local speed of sound values directly from the angular raw data. The proposed method robustly estimates the local speed of sound with only a few ultrasound emissions and with a low computational complexity which makes it compatible with real-time imaging. Simulations and in vitro experimental results show that the proposed method outperforms state-of-the-art approaches with biases and standard deviations lower than 10 m s−1, eight times fewer emissions, and 1000 times lower computational time. Further in vivo experiments validate its performance for liver imaging.

Published
2023
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7. POSTER VIEWING SESSION - ANDROLOGY

Author

E. C. Dul, C. M. A. van Ravenswaaij-Arts, H. Groen, J. van Echten-Arends, J. A. Land, Y. Tyulenev, V. Naumenko, L. Kurilo, L. Shileiko, A. Segal, R. Klimova, A. Kushch, J. Ribas-Maynou, A. Garcia-Peiro, C. Abad, M. J. Amengual, J. Benet, J. Navarro, A. Colasante, A. M. Lobascio, F. Scarselli, M. G. Minasi, E. Alviggi, P. Rubino, V. Casciani, R. Pena, M. T. Varricchio, K. Litwicka, S. Ferrero, D. Zavaglia, G. Franco, Z. P. Nagy, E. Greco, L. Romany, M. Meseguer, S. Garcia-Herrero, A. Pellicer, N. Garrido, A. Dam, A. Pijnenburg, J. C. Hendriks, J. R. Westphal, L. Ramos, J. A. M. Kremer, F. Eertmans, V. Bogaert, B. Puype, W. Geisler, C. Clusmann, I. Klopsch, T. Strowitzki, W. Eggert-Kruse, R. Maettner, E. Isachenko, V. Isachenko, E. Strehler, K. Sterzik, G. Band, I. Madgar, H. Brietbart, Z. Naor, J. S. Cunha-Filho, C. A. Souza, V. G. Krebs, K. D. Santos, W. J. Koff, A. Stein, I. Hammoud, M. Albert, M. Bergere, M. Bailly, F. Boitrelle, F. Vialard, R. Wainer, V. Izard, J. Selva, P. Cohen - Bacrie, S. Belloc, J. de mouzon, M. Cohen-Bacrie, S. Alvarez, A. M. Junca, M. Dumont, S. Douard, N. Prisant, K. Tomita, S. Hashimoto, Y. Akamatsu, M. Satoh, R. Mori, T. Inoue, Y. Ohnishi, K. Ito, Y. Nakaoka, Y. Morimoto, V. J. H. Smith, K. K. Ahuja, F. Atig, M. Raffa, M. T. Sfar, A. Saad, M. Ajina, D. P. A. F. Braga, G. Halpern, R. C. S. Figueira, A. S. Setti, A. Iaconelli Jr., E. Borges Jr., G. S. Medeiros, E. B. Pasqualotto, F. F. Pasqualotto, M. Nadalini, N. Tarozzi, M. Di Santo, A. Borini, C. Lopez-Fernandez, F. Arroyo, P. Caballero, R. Nunez-Calonge, J. L. Fernandez, J. Gosalvez, A. Gosalbez, S. Cortes, K. Zikopoulos, L. Lazaros, G. Vartholomatos, A. Kaponis, G. Makrydimas, N. Plachouras, N. Sofikitis, S. Kalantaridou, E. Hatzi, I. Georgiou, J. de Mouzon, E. Amar, P. Cohen-Bacrie, M. L. Vuillaume, F. Brugnon, C. Artonne, L. Janny, H. Pons-Rejraji, J. Fedder, L. Bosco, G. Ruvolo, A. M. Bruccoleri, M. Manno, M. C. Roccheri, E. Cittadini, I. Bochev, P. Gavrilov, S. Kyurkchiev, A. Shterev, G. Carlomagno, M. Colone, R. A. Condorelli, A. Stringaro, A. E. Calogero, J. Zakova, M. Kralikova, I. Crha, P. Ventruba, J. Melounova, M. Matejovicova, M. Vodova, E. Lousova, M. Sanchez Toledo, C. Alvarez LLeo, C. Garcia Garrido, M. Resta Serra, L. L. Belmonte Andujar, G. Gonzalez de Merlo, M. Pohanka, M. Huser, I. Amiri, J. Karimi, M. T. Goodarzi, H. Tavilani, A. Filannino, M. C. Magli, E. Boudjema, A. Crippa, A. P. Ferraretti, L. Gianaroli, F. Robles, H. Huang, D. J. Yao, H. J. Huang, J. R. Li, S. K. Fan, M. L. Wang, S. Yung-Kuei, S. Amer, A. Mahran, J. Darne, R. Shaw, E. Borghi, C. Cetera, U. Shukla, D. Ogutu, B. Deval, M. Jansa, M. Savvas, N. Narvekar, P. Houska, A. L. Dackland, L. Bjorndahl, U. Kvist, L. Muzii, B. Barboni, L. Samanta, S. Kar, S. A. Yakovenko, M. N. Troshina, B. K. Rutman, S. A. Dyakonov, E. Holmes, C. Feijo, S. Verza Junior, S. C. Esteves, C. L. Berta, A. M. Caille, S. A. Ghersevich, C. Zumoffen, M. J. Munuce, M. San Celestino, D. Agudo, M. Alonso, P. Sanjurjo, D. Becerra, F. Bronet, J. A. Garcia-Velasco, A. Pacheco, R. Lafuente, G. Lopez, M. A. Checa, R. Carreras, M. Brassesco, M. Oneta, V. Savasi, B. Parrilla, D. Guarneri, A. Laureti, F. Pagano, I. Cetin, E. Ekwurtzel, G. Morgante, P. Piomboni, A. Stendardi, F. Serafini, V. De Leo, R. Focarelli, M. Benkhalifa, J. De Mouzon, F. Entezami, A. Junca, J. J. De Mouzon, A. Mangiarini, E. Capitanio, A. Paffoni, L. Restelli, C. Guarneri, C. Scarduelli, G. Ragni, K. Harrison, J. Irving, N. Martin, D. Sherrin, A. Yazdani, C. Almeida, S. Correia, E. Rocha, A. Alves, M. Cunha, L. Ferraz, S. Silva, M. Sousa, A. Barros, A. Perdrix, A. Travers, J. P. Milazzo, F. Clatot, N. Mousset-Simeon, B. Mace, N. Rives, H. S. Clarke, A. Callow, D. Saxton, A. A. Pacey, O. Sapir, G. Oron, A. Ben-Haroush, R. Garor, D. Feldberg, H. Pinkas, A. Wertheimer, B. Fisch, E. Palacios, M. C. Gonzalvo, A. Clavero, J. P. Ramirez, A. Rosales, J. Mozas, J. A. Castilla, J. Mugica, O. Ramon, A. Valdivia, A. Exposito, L. Casis, R. Matorras, R. Bongers, F. Gottardo, M. Zitzmann, S. Kliesch, T. Cordes, A. Kamischke, A. Schultze-Mosgau, N. Buendgen, K. Diedrich, G. Griesinger, L. Crisol, F. Aspichueta, M. L. Hernandez, J. I. Ruiz-Sanz, R. Mendoza, A. A. Sanchez-Tusie, A. Bermudez, P. Lopez, G. C. Churchill, C. L. Trevino, I. Maldonado, and J. Dabbah

Subjects
medicine.medical_specialty, Reproductive Medicine, Rehabilitation, medicine, Obstetrics and Gynecology, Medical physics, Session (computer science), Psychology
Published
2011
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8. Andrology (Male Fertility, Spermatogenesis)

Author

Y. Matsumoto, S. Goto, H. Hashimoto, S. Kokeguchi, M. Shiotani, H. Okada, P. Cohen - Bacrie, A. Hazout, S. Belloc, J. De Mouzon, Y. Menezo, M. Dumont, A. M. Junca, M. Cohen-Bacrie, S. Alvarez, F. Olivennes, N. Prisant, M. Weltin, W. Geissler, C. Clussmann, T. Strowitzki, W. Eggert-Kruse, Y. Endou, Y. Fjii, H. Motoyama, F. Q. Quintana, Z. L. Zaloa Larreategui, I. P. Iratxe Penalba, S. O. Sara Ortega, M. M. Monica Martin, G. Q. Guillermo Quea, J. S. Jose Serna, M. G. Showell, J. Brown, A. Yazdani, M. T. Stankiewicz, R. J. Hart, C. Zumoffen, M. J. Munuce, A. Caille, S. Ghersevich, A. M. Lendinez, B. Perez-Nevot, A. R. Palomares, A. Serrano Garballo, A. Rodriguez, A. Reche, A. Mayor-Olea, M. Ruiz-Galdon, A. Reyes-Engel, J. Mendiola, N. Jorgensen, A. M. Andersson, A. M. Calafat, J. B. Redmon, E. Z. Drobnis, C. Wang, A. Sparks, S. W. Thurston, F. Liu, S. H. Swan, A. C. Tarasconi, B. V. Tarasconi, D. V. Tarasconi, E. M. V. Silva, Y. Fujii, I. Crha, J. Pribyl, P. Skladal, J. Zakova, P. Ventruba, M. Pohanka, G. De La Fuente, A. Pacheco, J. A. G. Velasco, A. Requena, A. Pacheco Castro, M. San Celestino Carchenilla, R. Salvanes, A. Arnanz, C. Balmori, A. Pellicer, J. A. Garcia-Velasco, T. Ishikawa, M. Fujisawa, S. Kranz, K. Hersemeyer, A. Hentrich, H. R. Tinneberg, L. Konrad, L. Simon, D. Lutton, J. McManus, S. E. M. Lewis, S. Rubio, P. Simon Sanjurjo, S. Lewis, J. Buzzi, A. Valcarcel, E. Lombardi, R. Oses, V. Rawe, E. Young, A. Magendzo, S. Lizama, G. Duque, A. Mackenna, A. Monqaut, C. Zavaleta, G. Lopez, R. Lafuente, M. Brassesco, R. Condorelli, S. La Vignera, S. La Rosa, N. Barone, E. Vicari, S. Bellanca, R. D'Agata, A. E. Calogero, M. Enciso, M. Iglesias, I. Galan, A. Gosalvez, J. Gosalvez, M. Curaba, J. Poels, A. Van Langendonckt, J. Donnez, C. Wyns, M. Garcez, M. Salvador, E. B. Pasqualotto, D. P. A. F. Braga, E. Borges, F. F. Pasqualotto, T. Aoki, R. C. S. Figueira, L. G. L. Maldonado, A. Iaconelli, R. Frassini, J. Mandelli, A. S. Setti, S. S. Cortezzi, M. Di Mauro, N. Burrello, J. Kashir, C. Jones, C. Young, M. Ruas, P. Grasa, K. Rietdorf, E. Heytens, B. Heindryckx, S. Y. Yoon, R. A. Fissore, C. M. Deane, D. Nikiforaki, S. T. Tee, P. de Sutter, J. Parrington, K. Coward, L. Visser, G. H. Westerveld, S. K. M. van Daalen, F. van der Veen, M. P. Lombardi, S. Repping, S. Cubillos, S. Sanchez, J. Pedraza, G. Charria, H. Aparicio, A. Gongora, F. Caldino, S. Cuneo, J. P. Ou, W. E. Zhao, Y. F. Liu, Y. W. Xu, C. Q. Zhou, N. Al-Asmar Pinar, V. Peinado, J. Gruhn, M. Susiarjo, M. Gil-Salom, J. M. Martinez-Jabaloyas, J. Remohi, C. Rubio, T. Hassold, N. Al-Asmar, L. Rodrigo, T. J. Hassold, M. Bungum, N. Forsell, A. Giwercman, I. Amiri, N. Sheikh, R. Najafi, M. Godarzi, M. Farimani, H. Makukh, M. Tyrkus, D. Zastavna, A. Nakonechnuy, S. S. Khayat, L. V. Schileiko, L. F. Kurilo, S. Garcia-Herrero, N. Garrido, J. A. Martinez-Conejero, L. Romany, M. Meseguer, B. Dorphin, M. Lefevre, C. Gout, P. Oger, C. Yazbeck, N. Rougier, S. De Stefani, V. Scala, S. Benedetti, M. C. Tagliamonte, E. Zavagnini, S. Palini, C. Bulletti, F. Canestrari, N. Subiran, F. M. Pinto, M. L. Candenas, E. Agirregoitia, J. Irazusta, E. M. Cha, J. H. Lee, I. H. Park, K. H. Lee, M. H. Kim, M. S. Jensen, C. Rebordosa, A. M. Thulstrup, G. Toft, H. T. Sorensen, J. P. Bonde, T. B. Henriksen, J. Olsen, L. Bosco, M. Speciale, M. Manno, N. Amireh, M. C. Roccheri, E. Cittadini, P. Wu, Y. M. Lee, H. W. Chen, C. R. Tzeng, J. Llacer, J. Ten, B. Lledo, A. Rodriguez-Arnedo, R. Morales, R. Bernabeu, A. Garcia-Peiro, J. Martinez-Heredia, M. Oliver-Bonet, J. Ribas, C. Abad, M. J. Amengual, J. Navarro, J. Benet, C. Moutou, N. Gardes, J. C. Nicod, N. Becker, M. P. Bailly, I. Galland, O. Pirello, C. Rongieres, C. Wittemer, S. Viville, W. Elmahaishi, B. Smith, A. Doshi, P. Serhal, J. C. Harper, C. Rennemeier, U. Kammerer, J. Dietl, P. Staib, K. Elgmati, M. Nomikos, M. Theodoridou, B. Calver, K. Swann, F. A. Lai, I. Georgiou, L. Lazaros, N. Xita, A. Kaponis, N. Plachouras, E. Hatzi, K. Zikopoulos, F. Ferfouri, P. Clement, D. Molina Gomes, M. Albert, M. Bailly, R. Wainer, J. Selva, F. Vialard, T. Takisawa, K. Usui, T. Kyoya, Y. Shibuya, H. Hattori, Y. Sato, M. Ota, K. Kyono, P. C. Chiu, K. K. Lam, C. L. Lee, M. K. Chung, V. W. Huang, W. S. O, F. Tang, P. C. Ho, W. S. Yeung, C. H. Kim, J. Y. Lee, S. H. Kim, C. S. Suh, Y. K. Shin, Y. J. Kang, J. H. Jung, C. Y. Cha, E. S. Hwang, T. Mukaida, M. Nagaba, K. Takahashi, D. Elkaffash, M. Sedrak, I. Huhtaniemi, T. Abdel-Al, D. Younan, N. G. Cassuto, D. Bouret, I. Hammoud, Y. Barak, S. Seshadri, M. Bates, G. Vince, D. I. Jones, M. Ben Khalifa, D. Montjean, P. Cohen-Bacrie, F. X. Aubriot, M. Cohen, E. Boudjema, M. C. Magli, A. Crippa, B. Baccetti, A. P. Ferraretti, L. Gianaroli, T. Singer, Q. V. Neri, J. C. Hu, R. Maggiulli, Z. Kollman, E. Rauch, P. N. Schlegel, Z. Rosenwaks, G. D. Palermo, B. Zorn, B. Skrbinc, E. Matos, B. Golob, M. Pfeifer, J. Osredkar, E. Sabanegh, R. K. Sharma, A. Thiyagarajan, A. Agarwal, G. Robin, F. Boitrelle, F. Marcelli, C. Marchetti, V. Mitchell, D. Dewailly, J. M. Rigot, N. Rives, A. Perdrix, A. Travers, J. P. Milazzo, N. Mousset-Simeon, B. Mace, A. Jakab, Z. Molnar, M. Benyo, I. Levai, Z. Kassai, A. Ihan, A. Kopitar, M. Kolbezen, D. Vaamonde, M. E. Da Silva-Grigoletto, J. M. Garcia-Manso, R. Vaamonde-Lemos, S. C. Oehninger, G. Walis, D. Monahan, E. Ermolovich, E. Fadlon, A. Abu Elhija, M. Abu Elhija, E. Lunenfeld, M. Huleihel, M. Costantini-Ferrando, J. C. Y. Hu, J. G. Alvarez, E. Velilla, M. Lopez-Teijon, C. Lopez-Fernandez, H. G. Tempest, F. Sun, E. Ko, P. Turek, R. H. Martin, M. T. Zomeno-Abellan, A. Ramirez, A. Gutierrez-Adan, J. C. Martinez, J. Landeras, J. Ballesta, M. Aviles, M. Ganaiem, S. Binder, A. Meinhardt, L. Sousa, A. Grangeia, F. Carvalho, M. Sousa, A. Barros, C. Sifer, N. Sermondade, E. Hafhouf, C. Poncelet, B. Benzacken, R. Levy, J. P. Wolf, L. Crisol, F. Aspichueta, M. L. Hernandez, A. Exposito, R. Matorras, M. B. Ruiz-Larrea, J. I. Ruiz-Sanz, S. Jallad, F. Atig, H. Ben Amor, A. L. I. Saad, A. Kerkeni, M. Ajina, A. L. I. Othmane, I. Koscinski, L. Ladureau, F. Scarselli, V. Casciani, M. Lobascio, M. G. Minasi, P. Rubino, A. Colasante, L. Arizzi, K. Litwicka, E. Iammarrone, S. Ferrero, C. Mencacci, G. Franco, D. Zavaglia, Z. P. Nagy, E. Greco, S. Ohgi, M. Takahashi, C. Kishi, K. Suga, A. Yanaihara, L. W. Chamley, A. Wagner, and A. N. Shelling

Subjects
Andrology, Reproductive Medicine, Phospholipase C, Point mutation, Rehabilitation, Obstetrics and Gynecology, Identification (biology), Biology, Sperm, Gene, Molecular biology
Published
2010
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9. Andrology

Author

M. S. C. Carchenilla, D. Agudo, S. Rubio, D. Becerra, F. Bronet, J. A. Garcia-Velasco, A. Pacheco, M. Lardone, A. Piottante, A. Parada-Bustamante, F. Argandona, M. Florez, A. Espinoza, M. Ebensperger, A. Castro, M. Cohen-Bacrie, S. Belloc, A. Dalleac, E. Amar, V. Izard, A. Hazout, P. Cohen-Bacrie, J. de Mouzon, F. Muzzonigro, A. M. Crivello, I. Stanghellini, L. Bernardini, A. P. Ferraretti, C. Magli, L. Gianaroli, P. S. Martin, M. H. Duvison, M. D. Silva, J. Gosalvez, F. S. Martin, A. Pomante, F. Colombo, M. Mattioli, B. Barboni, M. C. Magli, O. Hacifazlioglu, N. Findikli, U. Goktolga, M. Bahceci, A. Jakab, A. Mokanszki, A. Varga, M. Benyo, Z. Kassai, E. Olah, Z. Molnar, G. I. Gundogan, H. H. Bozkurt, T. Irez, A. Domingo, C. Anarte, N. Presilla, I. Calvo, O. Aguirre, A. Oroquieta, J. A. Agirregoikoa, J. L. De Pablo, G. Barrenetxea, I. Moragues, M. L. Medrano, A. Montoya, B. Ramos, M. J. G. Torres, J. Aizpurua, S. R. Ibala, H. Ghedir, A. Mehri, I. Zidi, S. Brahem, M. Mehdi, M. Ajina, A. Saad, M. J. Gomez-Torres, J. E. Cavaco, L. Rato, M. G. Alves, T. R. Dias, G. Lopes, S. Socorro, P. F. Oliveira, A. M. Lobascio, M. G. Minasi, E. Greco, M. Bungum, A. Bungum, N. Silver, M. Zahiri, M. Movahedin, S. J. Mowla, M. Noruzinia, M. Huleihel, Y. Abarbanel, E. P. Haber, M. Azab, D. Lan, E. Lunenfeld, M. J. Smith, Q. V. Neri, L. Harvey, Z. Rosenwaks, G. D. Palermo, M. Alhalabi, S. Samawi, H. Droubi, M. Khalaf, A. Taha, R. Khatib, A. Bednarowska-flisiak, M. Wcislo, J. Liss, A. Swider, J. Szczyglinska, M. Grzymkowska, A. Bruszczynska, J. Glowacka, K. Kitowska-Marszalkowska, M. Krapchev, A. Mirecka, K. Wisniewska, K. Lukaszuk, I. Natali, L. Tamburrino, M. Cambi, S. Marchiani, I. Noci, M. Maggi, G. Forti, E. Baldi, M. Muratori, X. Ferraretto, B. Pasquet, F. Damond, S. Matheron, S. Epelboin, S. Yahi, P. Demailly, N. Rougier, C. Yazbeck, L. Delaroche, P. Longuet, M. Llabador, C. Estellat, C. Patrat, M. Askarijahromi, M. Amanlu, S. j. Mowla, Z. Mazaheri, P. Christensen, E. S. Sills, R. Fischer, O. G. J. Naether, D. Walsh, K. Rudolf, G. Coull, V. Baukloh, R. Labouriau, A. Birck, F. Parisi, B. Parrilla, M. Oneta, V. Savasi, L. Veleva, T. Milachich, I. Bochev, I. Antonova, A. Shterev, V. Vlaisavljevic, B. P. Breznik, B. Kovacic, M. Serrano, M. C. Gonzalvo, A. Clavero, M. F. Fernandez, J. Mozas, L. Martinez, J. Fontes, S. Carrillo, M. L. Lopez-Regalado, B. Lopez-Leria, I. Orozco, A. Mantilla, J. A. Castilla, G. Mskhalaya, E. Zakharova, V. Zaletova, E. Kasatonova, Y. Melnik, E. Efremov, M. C. Schiewe, G. Verheyen, H. Tournaye, I. Phletincx, C. A. Sims, C. Rothman, E. Borges, A. S. Setti, D. P. A. F. Braga, L. Vingris, A. Iaconelli, C. Dupont, C. Faure, N. Sermondade, B. Gautier, C. Herbemont, I. Aknin, J. P. Klein, I. Cedrin-Durnerin, J. P. Wolf, S. Czernichow, R. Levy, C. Rondanino, C. Chauffour, L. Ouchchane, C. Artonne, L. Janny, J. M. Lobaccaro, D. H. Volle, F. Brugnon, N. Colacurci, P. Piomboni, G. Ruvolo, F. Lombardo, E. L. Verde, V. De Leo, M. Lispi, E. Papaleo, R. De Palo, L. Gandini, S. Longobardi, Y. Yokota, M. Yokota, H. Yokota, Y. Araki, S. Alshahrani, D. Durairajanayagam, R. Sharma, E. Sabanegh, A. Agarwal, H. Hattori, Y. Nakajo, T. Ikeno, Y. Sato, T. Kyoya, K. Kyono, B. Li, J. B. Li, X. F. Xiao, Y. F. Ma, J. Wang, X. X. Liang, H. X. Zhao, F. Jiang, Y. Q. Yao, X. H. Wang, N. R. Roan, H. Liu, J. Muller, A. Avila-Herrera, K. S. Pollard, P. Lishko, F. Kirchhoff, J. Munch, H. E. Witkowska, W. C. Greene, A. Mangiarini, A. Paffoni, L. Restelli, C. Guarneri, E. Somigliana, G. Ragni, R. Bou, M. Aleman, F. Guardiola, C. Camargo, J. B. A. Oliveira, C. G. Petersen, A. L. Mauri, F. C. Massaro, A. Nicoletti, A. M. Nascimento, L. D. Vagnini, A. M. V. C. Martins, M. Cavagna, R. L. R. Baruffi, and J. G. Franco

Subjects
Reproductive Medicine, Apoptosis, Rehabilitation, Varicocele, medicine, Obstetrics and Gynecology, Biology, medicine.disease, Sperm, Function (biology), Chromatin, Cell biology
Published
2013
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10. Pronostic en fécondation in vitro des patientes ayant une AMH basse et une FSH normale

Author

M. Khrouf, V. Grzegorczyk-Martin, J.-L. Benaim, P. Cohen-Bacrie, J. Belaisch-Allart, O. Kulski, J.-M. Mayenga, and S. Bringer-Deutsch

Subjects
Gynecology, medicine.medical_specialty, Reproductive Medicine, business.industry, medicine, Obstetrics and Gynecology, General Medicine, business
Abstract

Resume Objectif L’evaluation de la reserve ovarienne est indispensable dans la prise en charge de couples en fecondation in vitro (FIV) afin de predire la reponse ovarienne a la stimulation. Il semble aujourd’hui que l’hormone antimullerienne (AMH) en soit le meilleur marqueur. Notre etude s’interesse au pronostic de la FIV chez les couples dont la femme presente une AMH abaissee (≤ 2 ng/mL) malgre une FSH normale (≤ 10 mUI/mL) et un Estradiol normal (≤ 50 pg/mL). Patientes et methodes Une etude retrospective incluant 704 patientes prises en charge pour leur premiere tentative de FIV a ete menee dans notre centre d’assistance medicale a la procreation. Trois groupes ont ete definis et compares : les patientes du groupe 1 presentent une AMH inferieure ou egale a 2 ng/mL et une FSH inferieure ou egale a 10 mUI/mL (groupe d’etude), celles du groupe 2 une AMH superieure a 2 ng/mL et une FSH inferieure ou egale a 10 mUI/mL (groupe dit « normal ») et celles du groupe 3 une AMH inferieure ou egale a 2 ng/mL et une FSH superieure a 10 mUI/mL (groupe a reserve ovarienne tres perturbee). Resultats Les patientes du premier groupe ont des resultats en FIV significativement inferieurs a celles du deuxieme groupe quel que soit l’âge, et similaires a celles du troisieme groupe. L’AMH est significativement superieure a la FSH et l’âge pour predire la faible reponse ovarienne et l’annulation du cycle pour mauvaise reponse. Discussion et conclusion Cette etude confirme le fait qu’une AMH abaissee est correlee a un pronostic diminue en FIV, quelle que soit la valeur de la FSH. Le taux de succes est meilleur chez la femme jeune dans chaque groupe, mais reste inferieur a celui des patientes presentant une AMH normale. Ces resultats permettent d’informer les couples avant la premiere tentative et d’adapter le traitement de stimulation en FIV.

Published
2012
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11. Dynamique de l’index de vascularisation et de flux dans la phase préovulatoire de l’hyperstimulation ovarienne contrôlée. Relation avec le taux de conception

Author

E. Sedbon, P. Cohen-Bacrie, and P. Vignal

Subjects
Gynecology, medicine.medical_specialty, Reproductive Medicine, Ultrasound angiography, business.industry, Obstetrics and Gynecology, Medicine, General Medicine, 3d power doppler, Ultrasonography, business
Abstract

Resume Objectif Etudier l’evolution de l’index de vascularisation et de flux (IVF) sous-endometrial dans les cycles d’hyperstimulation ovarienne controlee (HOC + IIU) et comparer sa dynamique d’evolution chez les femmes enceintes et non enceintes. Patientes et methodes Il s’agit d’une etude retrospective effectuee sur 61 couples. Afin de determiner le profil de l’IVF en periode preovulatoire immediate, les patientes ont subi dans cette phase preovulatoire une angiographie endometriale par echographie 3D associee au Doppler puissance. Resultats Nous avons observe un profil decroissant de l’IVF dans 52 % (32/61) des cycles. A l’interieur des sous-groupes, ce profil decroissant a ete observe pour le sous-groupe avec pic spontane de LH (luteinizing hormone), dans 45 % (14/31) et pour le sous-groupe declenchement par hCG (human chorionic gonadotropin) dans 60 % (18/30). Il y a eu dix conceptions (10/61, 16,4 %), dont huit (8/32, 30 %) etaient associees avec un profil decroissant d’IVF contre deux (2/29,7 %) avec un profil croissant (NS). Dans les sous-groupes, nous avons observe : sous-groupe detection du pic de LH, cinq conceptions (5/14, 36 %) associees avec un profil decroissant contre une conception (1/17, 6 %) avec un profil croissant de VFI (odds-ratio pour une conception, 8,3 ; intervalle de confiance [IC] a 95 % : 0,8–444 ; p = 0,06 en faveur d’un profil decroissant de l’IVF) ; sous-groupe declenchement par HCG : trois conceptions (3/18, 17 %) avec IVF decroissant et une conception avec IVF croissant (1/12,8 %) (p = 0,6). Discussion et conclusion Un profil decroissant de l’IVF compare a un profil croissant est plus frequent dans l’hyperstimulation ovarienne controlee. Un tel profil semble etre associe a un taux de conception plus eleve dans les cycles avec pic de LH spontane.

Published
2012
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12. FEMALE (IN)FERTILITY

Author

S. Kanta Goswami, S. Banerjee, P. Saha, P. Chakraborty, S. N. Kabir, M. A. Karimzadeh, F. Mohammadian, M. Mashayekhy, P. Saldeen, K. Kallen, P. O. Karlstrom, K. A. Rodrigues-Wallberg, A. Salerno, A. Nazzaro, L. Di Iorio, S. Marino, C. Granato, G. Landino, E. Pastore, B. Ghoshdastidar, C. Chakraborty, B. N. Ghoshdastidar, S. Ghoshdastidar, G. A. Partsinevelos, M. Papamentzelopoulou, D. Mavrogianni, S. Marinopoulos, V. Dinopoulou, C. Theofanakis, E. Anagnostou, D. Loutradis, C. Franz, R. Nieuwland, M. Montag, A. Boing, S. Rosner, A. Germeyer, T. Strowitzki, B. Toth, M. Mohamed, A. Vlismas, L. Sabatini, A. Caragia, B. Collins, A. Leach, A. Zosmer, T. Al-Shawaf, Z. Beyhan, J. D. Fisch, C. Danner, L. Keskintepe, Y. Aydin, P. Ayca, T. Oge, H. Hassa, E. Papanikolaou, G. Pados, G. Grimbizis, H. Bili, K. Karastefanou, H. Fatemi, D. Kyrou, P. Humaidan, B. Tarlatzis, F. Gungor, B. Karamustafaoglu, A. C. Iyibozkurt, M. Ozsurmeli, E. Bastu, F. Buyru, G. Di Emidio, M. Vitti, A. Mancini, T. Baldassarra, A. M. D'Alessandro, F. Polsinelli, C. Tatone, F. Leperlier, J. Lammers, L. Dessolle, S. Lattes, P. Barriere, T. Freour, P. Elodie, S. Assou, E. Van den Abbeel, J. C. Arce, S. Hamamah, H. Dechaud, D. Haouzi, S. Tiplady, S. Johnson, G. Jones, W. Ledger, N. Eizadyar, S. Ahmad Nia, M. Seyed Mirzaie, S. A. Azin, M. Yazdani Safa, Y. Onaran, C. Iltemir Duvan, E. Keskin, A. Ayrim, H. Kafali, N. Kadioglu, B. Guler, T. Var, M. N. Cicek, A. S. Batioglu, I. Lichtblau, F. Olivennes, J. de Mouzon, M. Dumont, A. M. Junca, M. Cohen-Bacrie, A. Hazout, S. Belloc, P. Cohen-Bacrie, A. Allegra, A. Marino, F. Sammartano, F. Coffaro, P. Scaglione, S. Gullo, A. Volpes, N. Prisant, M. Saare, K. Vaidla, A. Salumets, M. Peters, U. N. Jindal, M. Thakur, V. Shvell, M. P. Diamond, A. O. Awonuga, M. Veljkovic, B. Macanovic, I. Milacic, D. Borogovac, B. Arsic, D. Pavlovic, D. Lekic, D. Bojovic Jovic, E. Garalejic, K. Jayaprakasan, H. Eljabu, J. Hopkisson, B. Campbell, N. Raine-Fenning, P. Kop, M. van Wely, B. W. Mol, A. A. Melker, P. M. W. Janssens, A. Nap, B. Arends, J. P. W. R. Roovers, H. Ruis, S. Repping, F. van der Veen, M. H. Mochtar, A. Sargin, N. Yilmaz, C. Gulerman, A. Guven, B. Polat, M. Ozel, Y. Bardakci, C. Vidal, J. Giles, J. Remohi, A. Pellicer, N. Garrido, M. Javdani, H. Fallahzadeh, R. Davar, H. Sheibani, C. Leary, S. Killick, R. G. Sturmey, S. G. Kim, K. H. Lee, I. H. Park, H. G. Sun, J. H. Lee, Y. Y. Kim, E. M. Choi, L. L. Van Loendersloot, M. Van Wely, P. M. M. Bossuyt, F. Van Der Veen, M. Roychoudhury Sarkar, D. Roy, R. Sahu, J. Bhattacharya, I. Eguiluz Gutierrez- Barquin, V. Sanchez Sanchez, A. Torres Afonso, M. Alvarez Sanchez, S. De Leon Socorro, J. Molina Cabrillana, S. Seara Fernandez, J. A. Garcia Hernandez, Z. S. Ozkan, M. Simsek, B. Kumbak, R. Atilgan, E. Sapmaz, J. A. Agirregoikoa, J. L. DePablo, E. Abanto, M. Gonzalez, C. Anarte, G. Barrenetxea, A. Aleyasin, A. Mahdavi, M. Agha Hosseini, L. Safdarian, P. Fallahi, F. Bahmaee, E. Sarikaya, T. Segawa, S. Teramoto, S. Tsuchiyama, O. Miyauchi, Y. Watanabe, T. Ohkubo, M. Shozu, H. Ishikawa, F. Yelian, S. Papaioannou, T. Knowles, M. Aslam, R. Milnes, A. Takashima, N. Takeshita, T. Kinoshita, M. G. Chapman, S. Kilani, N. Dadras, M. E. Parsanezhad, J. Zolghadri, M. Younesi, J. Floehr, E. Dietzel, J. Wessling, J. Neulen, B. Rosing, S. Tan, W. Jahnen-Dechent, K. S. Lee, J. K. Joo, J. B. Son, B. S. Joo, F. Risquez, E. Confino, F. Llavaneras, I. Marval, G. D'Ommar, M. Gil, M. Risquez, L. Lozano, A. Paublini, M. Piras, A. Risquez, R. Prochazka, M. Blaha, L. Nemcova, A. Weghofer, A. Kim, D. H. Barad, N. Gleicher, Y. Kilic, B. Ergun, B. Howard, H. Weiss, K. Doody, C. Schafer, S. Ensslen, B. Denecke, T. Veitinger, M. Spehr, T. Tropartz, R. Tolba, A. Egert, H. Schorle, S. Alanya, and H. Yumru

Subjects
Reproductive Medicine, Total fertility rate, media_common.quotation_subject, Rehabilitation, Obstetrics and Gynecology, Fertility, Biology, Demography, Age and female fertility, media_common
Published
2012
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13. POSTER VIEWING SESSION - REPRODUCTIVE (EPI) GENETICS

Author

B. Acar-Perk, J. Weimer, K. Koch, A. Salmassi, N. Arnold, L. Mettler, A. G. Schmutzler, C. S. Ottolini, D. K. Griffin, A. H. Handyside, M. C. Summers, A. R. Thornhill, D. Montjean, M. Benkhalifa, P. Cohen-Bacrie, J. P. Siffroi, J. Mandelbaum, I. Berthaut, A. Bashamboo, C. Ravel, K. McElreavey, A. Ao, X. Y. Zhang, A. Yilmaz, J. T. Chung, E. Demirtas, W. Y. Son, M. Dahan, W. Buckett, H. Holzer, S. L. Tan, A. Perheentupa, M. Vierula, N. Jorgensen, N. E. Skakkebaek, S. Chantot-Bastaraud, J. Toppari, L. Muzii, M. C. Magli, L. Gioia, M. Mattioli, A. P. Ferraretti, L. Gianaroli, I. Koscinski, E. Elinati, C. Fossard, P. Kuentz, Z. Kilani, A. Demirol, T. Gurgan, F. Schmitt, J. Velez de la Calle, N. Iqbal, N. Louanjli, M. Pasquier, F. Carre-Pigeon, J. Muller, C. Barratt, S. Viville, C. Magli, C. Grugnetti, E. Castelletti, B. Paviglianiti, L. Pepas, P. Braude, J. Grace, V. Bolton, Y. Khalaf, T. El-Toukhy, I. Galeraud-Denis, H. Bouraima, L. Sibert, N. Rives, S. Carreau, F. Janse, L. M. de With, B. C. J. M. Fauser, C. B. Lambalk, J. S. E. Laven, A. J. Goverde, J. C. Giltay, V. De Leo, L. Governini, A. Quagliariello, M. A. Margollicci, P. Piomboni, A. Luddi, H. Miyamura, H. Nishizawa, S. Ota, M. Suzuki, A. Inagaki, H. Egusa, S. Nishiyama, T. Kato, I. Nakanishi, T. Fujita, Y. Imayoshi, A. Markoff, I. Yanagihara, Y. Udagawa, H. Kurahashi, B. Alvaro Mercadal, R. Imbert, I. Demeestere, A. De Leener, Y. Englert, S. Costagliola, A. Delbaere, E. Velilla, A. Colomar, E. Toro, S. Chamosa, J. Alvarez, M. Lopez-Teijon, S. Fernandez, Y. Hosoda, A. Hasegawa, N. Morimoto, Y. Wakimoto, Y. Ito, S. Komori, L. Sati, C. Zeiss, R. Demir, J. McGrath, S. Y. Ku, Y. J. Kim, Y. Y. Kim, H. J. Kim, K. E. Park, S. H. Kim, Y. M. Choi, S. Y. Moon, A. Minor, V. Chow, S. Ma, E. Martinez Mendez, M. Gaytan, A. Linan, A. Pacheco, M. San Celestino, C. Nogales, M. Ariza, D. Cernuda, F. Bronet, A. M. Lendinez Ramirez, A. R. Palomares, B. Perez-Nevot, V. Urraca, A. Ruiz Martin, A. Reche, M. Ruiz Galdon, A. Reyes-Engel, N. R. Treff, X. Tao, D. Taylor, B. Levy, K. M. Ferry, R. T. Scott Jr., S. Vasan, K. K. Acharya, B. Vasan, R. Yalaburgi, K. K. Ganesan, S. C. Darshan, C. H. Neelima, P. Deepa, B. Akhilesh, D. Sravanthi, K. S. Sreelakshmi, H. Deepti, J. H. van Doorninck, C. Eleveld, M. van der Hoeven, E. Birnie, E. A. P. Steegers, R. J. Galjaard, I. M. van den Berg, F. Fiorentino, L. Spizzichino, S. Bono, A. Biricik, G. Kokkali, L. Rienzi, F. M. Ubaldi, E. Iammarrone, A. Gordon, K. Pantos, E. Oitmaa, A. Tammiste, S. Suvi, M. Punab, M. Remm, A. Metspalu, A. Salumets, L. Rodrigo, P. Mir, A. Cervero, E. Mateu, A. Mercader, C. Vidal, J. Giles, J. Remohi, A. Pellicer, J. Martin, C. Rubio, H. Mozdarani, S. Moghbeli Nejad, M. Behmanesh, A. Alleyasin, H. Ghedir, S. Ibala-Romdhane, O. Mamai, S. Brahem, H. Elghezal, M. Ajina, M. Gribaa, A. Saad, M. C. Martinez, V. Peinado, M. Milan, N. Al-Asmar, P. Buendia, A. Delgado, L. Escrich, B. Amorocho, C. Simon, L. Petrussa, H. Van de Velde, N. De Munck, M. De Rycke, S. Altmae, J. A. Martinez-Conejero, F. J. Esteban, M. Ruiz-Alonso, A. Stavreus-Evers, J. A. Horcajadas, B. Bug, G. Raabe-Meyer, U. Bender, J. Zimmer, B. Schulze, P. H. Vogt, T. Laisk, M. Peters, V. Grabar, A. Feskov, E. Zhilkova, N. Sugawara, M. Maeda, T. Seki, T. Manome, R. Nagai, Y. Araki, I. Georgiou, L. Lazaros, N. Xita, A. Chatzikyriakidou, A. Kaponis, N. Grigoriadis, E. Hatzi, I. Grigoriadis, N. Sofikitis, K. Zikopoulos, M. Gunn, P. R. Brezina, A. Benner, L. Du, W. G. Kearns, X. Shen, C. Zhou, Y. Xu, Y. Zhong, Y. Zeng, G. Zhuang, M. C. Gunn, K. Richter, P. Andreeva, I. Dimitrov, M. Konovalova, S. Kyurkchiev, A. Shterev, A. Daser, E. Day, H. Turley, A. Immesberger, T. Haaf, T. Hahn, P. H. Dear, M. Schorsch, J. Don, N. Golan, T. Eldar, and R. Yaverboim

Subjects
03 medical and health sciences, medicine.medical_specialty, 030219 obstetrics & reproductive medicine, 0302 clinical medicine, Reproductive Medicine, business.industry, Rehabilitation, medicine, Obstetrics and Gynecology, Medical physics, Session (computer science), business
Published
2011
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14. Session 66: Understanding the Male Genome

Author

Masato Fujisawa, S. Kamidono, Lawrence Dierickx, C.W. Bak, Stéphane Viville, Christophe Arnoult, M López-Teijón, Yorgos Nikas, E. Velilla, S. Sung, Radu Harbuz, Debbie Montjean, J. Bujan, P. Cohen Bacrie, Moncef Benkhalifa, J.A. Grootegoed, D.R. Lee, N. Prisant, Pierre F. Ray, Isabelle Koscinski, E. Wassenaar, J. Montagut, David Gentien, S. Chamosa, Joop S.E. Laven, E Toro, Sylviane Hennebicq, Willy M. Baarends, S. Zerdoud, Sam Schoenmakers, D. Nogueira, M. Ben Khelifa, T.E. Shin, Yves Menezo, S.H. Song, R. Nose, Jean-Pierre Siffroi, T. Matsui, A Colomar, Joël Lunardi, P. De la Grange, E. Huyghe, Mahmoud Kharouf, F. Courbon, Raoudha Zouari, T. Ishikawa, P. Plante, Jessica Escoffier, S. Fernandez, and T.K. Yoon

Subjects
Genetics, Reproductive Medicine, Rehabilitation, Obstetrics and Gynecology, Session (computer science), Biology, Genome
Published
2010
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15. Posters * Fertility Preservation

Author

R. Talevi, V. Barbato, V. Mollo, C. De Stefano, F. Finelli, R. Ferraro, R. Gualtieri, P. Zhou, A. H. Liu, Y. X. Cao, H. Roman, I. Pura, O. Tarta, N. Bourdel, L. Marpeau, J. C. Sabourin, M. Portmann, Z. P. Nagy, B. Behr, B. Alvaro Mercadal, I. Demeestere, R. Imbert, Y. Englert, A. Delbaere, S. Lueke, N. Buendgen, F. Koester, K. Diedrich, G. Griesinger, A. Kim, J. E. Han, C. Eunmi, Y. S. Kim, J. H. Cho, T. K. Yoon, P. Piomboni, A. Stendardi, D. Palumberi, G. Morgante, V. De Leo, F. Serafini, R. Focarelli, C. Tatone, G. Di Emidio, M. C. Carbone, M. Vento, R. Ciriminna, P. G. Artini, K. Kyono, T. Ishikawa, K. Usui, M. Hatori, L. Yasmin, E. Sato, M. Iwasaka, K. Fujii, N. Owada, T. Sankai, M. McLaughlin, P. Fineron, R. A. Anderson, W. H. B. Wallace, E. E. Telfer, S. Labied, A. Beliard, C. Munaut, J. M. Foidart, I. Turkcuoglu, K. Oktay, K. Rodriguez-Wallberg, M. Kuwayama, Y. Takayama, C. Mori, N. Kagawa, N. Akakubo, Y. Takehara, K. Kato, S. P. Leibo, O. Kato, H. Yoon, Y. Shin, J. cha, H. Kim, W. Lee, S. Yoon, J. Lim, M. G. Larman, D. K. Gardner, D. Zander-Fox, M. Lane, H. Hamilton, S. Lee, S. Ozkavukcu, E. Heytens, R. M. Alappat, M. Sole, M. Boada, M. Biadiu, J. Santalo, B. Coroleu, P. N. Barri, A. Veiga, L. Rossi, R. Bartoletti, M. Mengarelli, G. Boccia Artieri, L. Gemini, L. Mazzoli, L. Giannini, G. Scaravelli, S. J. Silber, S. Yamanguchi, Y. Nagumo, Y. Takai, S. Ishihara, R. Soleimani, I. Rottiers, A. Gojayev, A. C. Cuvelier, P. De Sutter, M. Salama, K. Winkler, K. F. Murach, S. Hofer, L. Wildt, S. C. Friess, N. Okumura, N. Kuji, A. Kishimi, H. Nishio, Y. Mochimaru, K. Minegishi, K. Miyakoshi, T. Fujii, M. Tanaka, D. Aoki, Y. Yoshimura, K. Hasegawa, S. Juanzi, W. Zhao, S. Zhang, X. Xue, S. Silber, J. Zhang, D. Meirow, R. Gosden, J. R. Westphal, R. Gerritse, C. C. M. Beerendonk, D. D. M. Braat, R. Peek, G. Coticchio, M. Dal Canto, F. Brambillasca, M. Mignini Renzini, M. Merola, M. Lain, R. Fadini, S. A. Nottola, E. Albani, C. Lorenzo, T. Carlini, M. Maione, A. Borini, G. Macchiarelli, P. E. Levi-Setti, L. Rienzi, S. Romano, A. Capalbo, B. Iussig, L. Albricci, S. Colamaria, E. Baroni, F. Sapienza, M. Giuliani, R. Anniballo, F. M. Ubaldi, D. A. Beyer, A. Schultze-Mosgau, F. Amari, S. Al-Hasani, S. Resta, M. C. Magli, A. Ruberti, M. Lappi, A. P. Ferraretti, L. Gianaroli, N. Prisant, S. Belloc, M. Cohen-Bacrie, A. Hazout, F. Olivennes, F. X. Aubriot, S. Alvarez, J. De Mouzon, C. Thieulin, P. Cohen-Bacrie, S. Wozniak, P. Szkodziak, E. Wozniakowska, M. Paszkowski, T. Paszkowski, D. Diaz, S. Dragnic, B. Hayward, R. Bennett, A. Al-Sabbagh, E. Novella-Maestre, J. Teruel, L. Carmona, E. Rosello, A. Pellicer, M. Sanchez-Serrano, J. R. Lee, J. Y. Lee, C. H. Kim, Y. Lee, B. C. Jee, C. S. Suh, S. H. Kim, S. Y. Moon, V. Mirabet, J. Crespo, M. Schiewe, N. Nugent, S. Zozula, R. Anderson, J. F. Zulategui, M. Meseguer, J. Remohi, D. Castello, J. L. L. Romero, M. J. De los Santos, A. C. Cobo, M. von Wolff, J. Jauckus, M. Kupka, T. Strowitzki, B. Lawrenz, H. Raanani, B. Kaufman, E. Maman, M. M. Mendel, J. Dor, N. K. Buendgen, C. Combelles, H. Y. Wang, C. Racowsky, L. Kuleshova, M. Tucker, J. Graham, K. Richter, J. Carter, and M. Levy

Subjects
Gynecology, Pathology, medicine.medical_specialty, Ideal (set theory), Reproductive Medicine, business.industry, Ovarian tissue, Rehabilitation, medicine, Obstetrics and Gynecology, business
Published
2010
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17. Causes et implications cliniques des altérations de l’ADN des spermatozoïdes

Author

Jacqueline Selva, Patrick Madelenat, P. Cohen-Bacrie, Chadi Yazbeck, Y. Menezo, and André Hazout

Subjects
Infertility, Genetics, Mutation, DNA damage, Obstetrics and Gynecology, General Medicine, Apert syndrome, Reproductive technology, Biology, medicine.disease, medicine.disease_cause, Reproductive Medicine, medicine, DNA fragmentation, Conceptus, Genomic imprinting
Abstract

Numerous recent studies involve DNA damages associated with poor fertilization rates, early embryo development defect, and poor quality of conceptus following Assisted Reproductive Technologies (ART). The authors denounce a particularly high rate of miscarriages and childhood cancer or dominant genetic mutations such as achondroplasia, Apert syndrome or aberrant gene imprinting such as Angelman and Beckwith Wiedeman syndromes. Gametes DNA defects have numerous origins which are difficult to determine; they are known to involve hypomethylation, oxydative stress and environmental factors.(adducts formation). DNA defect is also linked to a more or less delayed apoptotic phenomenon. Exposure to radiations or radiofrequency electromagnetic emissions can also induce DNA alterations into the spermatozoa of infertile men. Although the underlying mechanisms are unclear, these DNA defects have obvious consequences on reproduction of mammalian species. Detection of such anomalies before ART, are an important step toward developing strategies for clinical management according to the aetiology.

Published
2008
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19. [Low circulating anti-Müllerian hormone and normal follicle stimulating hormone levels: which prognosis in an IVF program?]

Author

V, Grzegorczyk-Martin, M, Khrouf, S, Bringer-Deutsch, J-M, Mayenga, O, Kulski, P, Cohen-Bacrie, J-L, Benaim, and J, Belaisch-Allart

Subjects
Adult, Anti-Mullerian Hormone, Estradiol, Pregnancy Rate, Oocyte Retrieval, Fertilization in Vitro, Prognosis, Ovulation Induction, Pregnancy, Humans, Female, Follicle Stimulating Hormone, Birth Rate, Retrospective Studies
Abstract

To evaluate the results of controlled ovarian hyperstimulation (COH) for IVF in patients with low anti-Müllerian hormone (AMH) and normal basal follicle stimulating hormone (FSH) and Estradiol levels (≤50 pg/mL).A retrospective cohort study including 704 patients for whom AMH and FSH levels (measured between days 3 and 5 of the menstrual cycle) were available, is performed in the IVF center at the Sèvres Hospital (France). Three groups are designed and analyzed: group 1 with AMH less or equal to 2 ng/mL and FSH less or equal to 10 mUI/mL (study group), Group 2 with AMH greater than 2 ng/mL and FSH less or equal to 10 mUI/mL (control group) and Group 3 with AMH less or equal to 2 ng/mL and FSH greater than 10 mUI/mL (group with decreased ovarian reserve).IVF outcome for patients from the study group is significantly worse than that of the second but not than that of the third group. In the first group, the number of retrieved oocytes, the number of total obtained embryos, the clinical pregnancy rate and the live birth rate are significantly lower than in the second group; moreover, there are more cancelled cycles because of poor response in the first group. There is no difference with the third group.This study shows that women with a low baseline AMH have a similar response to COH to the poor responders patients with a decreased ovarian reserve revealed by an elevated FSH level. Thus, when a woman undergoing IVF cycle presents a low AMH, she might be considered as a poor responder patient regardless of the FSH level and, although the clinical pregnancy rate is not so disappointing (18%), the couple should be informed of a higher risk of cycle cancellation.

Published
2011

20. [Flow Index Vascularization dynamics in the preovulatory phase of controlled ovarian hyperstimulation: profile and relationship with conception rate]

Author

P, Vignal, P, Cohen-Bacrie, and E, Sedbon

Subjects
Adult, Endometrium, Ovulation Induction, Pregnancy, Fertilization, Angiography, Humans, Female, Ultrasonography, Doppler, Luteinizing Hormone, Middle Aged, Chorionic Gonadotropin, Retrospective Studies
Abstract

To study the evolution of subendometrial vascularization flow index (VFI) in controlled ovarian hyperstimulation (COH+IIU) cycles and compare its dynamic changes in pregnant and non pregnant women.This is a retrospective study on 61 couples. To determine the profile of IVF just before ovulation, patients had 3D-Power Doppler angiography (3D-PDA) in this precise preovulatory phase.We observed a decreasing profile of VFI in 52% (32/61) of the main group cycles, in 45% (14/31) of the subgroup with spontaneous peak of LH (luteinizing hormone), and in 60% (18/30) of the hCG (human chorionic gonadotropin) trigger subgroup. There were ten conceptions, (10/61, 16.4%), including eight (8/32, 30%) that were associated with a decreasing profile of VFI versus two (2/29, 7%) that were associated with an increasing profile (NS). In the detection of LH peak subgroup, we observed five conceptions (5/14, 36%) associated with a decreasing profile versus one conception (1/17, 6%) associated with an increasing profile of VFI (OR: 8.3; confidence interval [CI] 95%: 0.8-444; P=0.06 in favor of a of decreasing VFI profile). In the hCG subgroup, there were three conceptions in the decreasing VFI profile (3/18, 17%) and one conception with increasing VFI (1/12, 17%, P=0.6).In controlled ovarian hyperstimulation, a decreasing VFI profile is more common compared to an increasing one. Such au profile seems to be associated with a higher conception rate in cycles with spontaneous LH surge.

Published
2011

21. [Teratozoospermia, myth or reality? A 10-years retrospective study on 101404 consecutive sperm samples]

Author

N, Prisant, P, Cohen-Bacrie, E, Amar, J, Belaisch-Allart, M, Cohen-Bacrie, F, Olivennes, F-X, Aubriot, and S, Belloc

Subjects
Adult, Male, Semen Analysis, Sperm Count, Sperm Motility, Humans, Sperm Head, Hydrogen-Ion Concentration, Spermatozoa, Retrospective Studies
Abstract

Several studies have reported a time-related decline in semen quality. In this context, 101,404 spermograms-spermocytograms performed in a single andrology laboratory from January 2000 to December 2009 were investigated retrospectively. Variations of sperm parameters were analyzed over the years.For each semen sample, age at semen collection, duration of sexual abstinence, volume of seminal fluid, pH, concentration of spermatozoa, percentages of overall motile and progressive motile sperm, percentage of morphologically abnormal spermatozoa (according to David's classification) and amplitude of lateral head displacement (ALH) were analyzed. For each parameter, the mean value per year was determined. To examine trends over time the statistical tests used were analyses of variance and correlation studies.Data showed an increasing age of patients from 36.5 years in 2000 to 37.2 years in 2009. The semen concentration was 63.5 millions/mL in 2000 and 63.6 millions/mL in 2009 with a slight fall from 2001 to 2008. The vitality continuously increased from 67.8% in 2000 to 73.5% in 2009 as well as the overall motility (from 37.7% to 39.2%) and the progressive motility (from 34.6% to 36.2%). The percentage of morphologically abnormal spermatozoa continuously increased from 64.5% to 84.2% (r=0.43, P0.001).Contrary to a variety of works, our very large study of semen analysis did not show a real decline in semen WHO parameters during a 10-year period, except for the percentage of morphologically abnormal spermatozoa, which dramatically increased over the years.

Published
2010

22. [Teratozoospermia at the time of intracytoplasmic morphologically selected sperm injection (IMSI)]

Author

A-M, Junca, P, Cohen-Bacrie, S, Belloc, M, Dumont, and Y, Ménézo

Subjects
Male, Pregnancy Rate, Pregnancy, Pregnancy Outcome, Sperm Motility, Humans, Sperm Head, Female, DNA Fragmentation, Sperm Injections, Intracytoplasmic, Spermatozoa, DNA Damage
Abstract

Until now, the morphological sperm analysis (spermocytogram) allows to define sperm normality, but the relationship between sperm morphology and fertility is not yet assessed. Although several studies do not report any relationship between abnormal sperm morphology and ICSI results, nevertheless, the success rate of ICSI sems to be dependent on injected sperm morphological aspect. Detailed morphological sperm examination (especially sperm head) at high magnification (from x 6600 to x 12500) (MSOME) in real time allows to select the best spermatozoa before oocyte injection (IMSI). In some cases, implantation and ongoing pregnancy rates were improved with this sperm selection method. Ultramorphologic criteria were established and the most predictive factor of sperm quality is the presence of vacuoles in the sperm head. Those vacuoles appear to be related to DNA damage (fragmentation and/or denaturation) and affect embryo development. To standardize those observations, several authors tried to establish sperm MSOME classifications in order to be used in routine and to replace the conventional spermocytogram in the next future.

Published
2009

23. [Quality of follow-up of children]

Author

P, Cohen-Bacrie and C, Ramogida

Subjects
Reproductive Techniques, Assisted, Population Surveillance, Humans, Child
Abstract

A nonmedical follow-up of the children born through ART is recommended by guidelines to evaluate any consequences, whether beneficial or harmful, of their mode of conception. Governed by medical confidentiality, according to the CNIL, this follow-up should not be done only through a questionnaire but by a direct relation with a healthcare professional. FOLLOW UP, used in 27 ART centers in France, is an example of this follow-up.

Published
2008

24. [Sperm quality and selection]

Author

P, Cohen-Bacrie

Subjects
Male, Sperm Motility, Humans, Sperm Injections, Intracytoplasmic, Sperm Capacitation, Spermatozoa
Abstract

Selection of a live and morphologically normal spermatozoa is a fundamental stage in ICSI success because of its potential effects on early and late embryo development. In addition to the routine tests such as the spermogram and the spermocytogram, a number of tests have been developed for this purpose : the hyaluronic acid test, which measures the rate of DNA fragmentation using TUNEL (% of fragmented DNA) or electrophoresis separation of SPZ, SPZ evaluation using the FISH method, MSOME (motile sperm organelle morphology examination) techniques, et IMSI (intracytoplasmic morphologically selected sperm injection), which can evaluate the nuclear vacuoles, etc.

Published
2008

25. [Indications for IMSI]

Author

P, Cohen-Bacrie, M, Dumont, A M, Junca, S, Belloc, and A, Hazout

Subjects
Male, Humans, Sperm Injections, Intracytoplasmic, Infertility, Male
Abstract

ICSI failures (essentially fertilization and implantation failures) can be due to the quality of the oocytes, the spermatozoon injected and its manipulation, uterine factors and paternal factors, such as DNA fragmentation of the spermatozoa. Pre-selection of the spermatozoon is the crucial phase for ensuring successful ICSI. The characteristics of the sperm must be checked under the microscope at a magnification of x 6600 as certain abnormalities, in particular nuclear vacuoles, cannot be seen at x 300. In our centre, we conducted a study on 72 patients which showed that with more than 30% of fragmented DNA, neither implantation or birth was achieved using ICSI. Performing IMSI on the same patients allowed us to obtain implantation rates of 17.4% with 30 to 40 % of fragmented DNA and of 33.3% above 40%. Births were achieved in 17.4% and 28.6% of cases respectively. IMSI has the advantage of allowing extremely careful selection of the spermatozoon microinjected, so that it is of normal shape, with the least vacuoles possible and a low DNA fragmentation rate. It is, however, a complicated technique that cannot be routinely performed.

Published
2008

26. [Causes and clinical implications of sperm DNA damages]

Author

A, Hazout, Y, Menezo, P, Madelenat, C, Yazbeck, J, Selva, and P, Cohen-Bacrie

Subjects
Adult, Male, Oxidative Stress, Reproduction, Mutation, In Situ Nick-End Labeling, Humans, Spermatozoa, Infertility, Male, DNA Damage
Abstract

Numerous recent studies involve DNA damages associated with poor fertilization rates, early embryo development defect, and poor quality of conceptus following Assisted Reproductive Technologies (ART). The authors denounce a particularly high rate of miscarriages and childhood cancer or dominant genetic mutations such as achondroplasia, Apert syndrome or aberrant gene imprinting such as Angelman and Beckwith Wiedeman syndromes. Gametes DNA defects have numerous origins which are difficult to determine; they are known to involve hypomethylation, oxydative stress and environmental factors.(adducts formation). DNA defect is also linked to a more or less delayed apoptotic phenomenon. Exposure to radiations or radiofrequency electromagnetic emissions can also induce DNA alterations into the spermatozoa of infertile men. Although the underlying mechanisms are unclear, these DNA defects have obvious consequences on reproduction of mammalian species. Detection of such anomalies before ART, are an important step toward developing strategies for clinical management according to the aetiology.

Published
2007

27. [ICSI: can one select the spermatozoids?]

Author

A M, Junca, P, Cohen-Bacrie, and A, Hazout

Subjects
Male, Treatment Outcome, Pregnancy, Humans, Female, DNA Fragmentation, Sperm Injections, Intracytoplasmic, Spermatozoa, Infertility, Male, Retrospective Studies
Published
2005

28. SESSION 44: TREATMENT OUTCOMES

Author

A. S. Setti, D. P. A. F. Braga, R. C. S. Figueira, T. Aoki, A. Iaconelli, E. Borges, M. Caanen, E. Kuijper, R. Homburg, P. Hompes, M. Kushnir, C. B. Lambalk, D. Monahan, Q. Neri, J. Kocent, P. N. Schlegel, Z. Rosenwaks, G. D. Palermo, S. Belloc, J. de Mouzon, M. Cohen-Bacrie, I. Lichtblau, M. Dumont, A. M. Junca, A. Hazout, P. Cohen-Bacrie, A. J. Bensdorp, C. P. W. M. Hukkelhoven, B. W. Mol, and M. van Wely

Subjects
medicine.medical_specialty, Reproductive Medicine, business.industry, Rehabilitation, Treatment outcome, Physical therapy, Obstetrics and Gynecology, Medicine, Session (computer science), business
Published
2012
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30. [Non-obstructive azoospermia and ICSI]

Author

M, Adjiman, F X, Aubriot, A, Glissant, A, Hazout, C, Nathan, A, Stanovici, M, Dumont, and P, Cohen-Bacrie

Subjects
Cryopreservation, Male, Humans, Fertilization in Vitro, Oligospermia, Spermatozoa, Insemination, Artificial, Semen Preservation
Abstract

50 cases of non obstructive azoospermia required testicular sperm extraction and ICSI. Results are promising but ability to find spermatozoa remains questionable. Further studies are necessary to improve success of the method. Genetic research also need to be developed for better understanding the process.

Published
1998

32. [Microinjection in France: report of the BLEFCO multicentric study]

Author

P, Cohen-Bacrie, S, Hamamah, J, Parinaud, and S, Zerah

Subjects
Male, Cytoplasm, Microinjections, Pregnancy, Pregnancy Outcome, Humans, Female, Fertilization in Vitro, France, Embryo Transfer, Zona Pellucida
Abstract

In order to evaluate the assisted fertilizations in France, BLEFCO association has analysed 436 and 1,781 attempts for SUZI and ICSI respectively. For SUZI, the transfer rate was 62% and the pregnancy per attempt rate was 10%. For ICSI, whatever indications, the transfer rate was 86% and the pregnancy per attempt rate was 21%. ICSI in cases of altered sperm without previous IVF represented 46% of ICSI attempts. No relationship between the transfer rate and the indication of ICSI has been observed. However, in case of unexplained fertilization failures, the pregnancy per attempt rate is significantly lower when compared to the other indications.

Published
1995

33. [The importance of the preoperative measurement of hemoglobin concentration. Evaluation of a colorimetric method (Hemocue)]

Author

M, Sfez, P, Desruelle, G F, Pennecot, and P, Cohen-Bacrie

Subjects
Adult, Aged, 80 and over, Adolescent, Infant, Middle Aged, Hemoglobins, Evaluation Studies as Topic, Child, Preschool, Preoperative Care, Hemoglobinometry, Humans, Colorimetry, Child, Aged
Abstract

The present study compares two methods of haemoglobin measurement during surgery in 40 patients aged 1 to 85 years. The reference method is the Coulter STKS based on red cell count and mean cellular content in haemoglobin measurement. The method tested (Hemocue-Diagnostics Transfusion) allows instantaneous determination of haemoglobin on a 10 mu sample by measuring infrared absorption by haemoglobin in the 565 and 880 nm wavelengths. These methods have been compared using the method of assessment of agreement described by Bland and Altman. As previous reports suggested that the precision of haemoglobin measurement by Hemocue could depend on the capillary or venous site of sampling, we assessed agreement of the two methods of measurement of haemoglobin at both sites. In addition, the relationship between hematocrit and haemoglobin measured by either method has been assessed. On venous samples, there was a good agreement between the two methods of measurement of haemoglobin (n = 47), with a mean difference of -0.166 g/dl-1 and agreement limits of -1.041 g/dl-1 and +0.195 g/dl-1. Ninety six percent of the observed differences to two methods were within the 95% confidence interval. On capillary samples, there was a poor agreement between Hemocue and Coulter since the mean difference was -0.272 g/dl-1 with the following limits of agreement: -2.356 g/dl-1 and +1.812 g/dl-1. Only 92% of the observed differences were within the 95% confidence interval, with 17% of these being greater than the clinically accepted limit of 1 g/dl-1. The precision of Hemocue measurement of capillary blood haemoglobin was only +/- 16%.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1991

37. Ultrasons focalisés de forte intensité pour la thérapie transcrânienne du cerveau.

Author

Aubry, J.-F., Marsac, L., Pernot, M., Robert, B., Boch, A.-L., Chauvet, D., Salameh, N., Souris, L., Darasse, L., Bittoun, J., Martin, Y., Cohen-Bacrie, C., Souquet, J., Fink, M., and Tanter, M.

Subjects
MAGNETIC resonance imaging of the brain, BRAIN tomography, ULTRASONIC encephalography, MEDICAL thermometry, TREATMENT of brain cancer, BRAIN diseases, PATIENTS
Abstract

Copyright of IRBM is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2010
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38. Diagnostic bactériologique des infections chez les greffés.

Author

Cohen-Bacrie, Stéphan, Cointault, Olivier, Clavé, Danielle, Archambaud, Maryse, and Marty, Nicole

Subjects
COMPLICATIONS from organ transplantation, STEM cell transplantation, BACTERIAL diseases, BACTEREMIA, CYSTIC fibrosis, MYCOBACTERIUM, IMMUNOSUPPRESSION, ANTIBIOTICS, PROGNOSIS
Abstract

Copyright of Revue Francophone des Laboratoires is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2008
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39. Multiparameter analysis of human oocytes at metaphase II stage after IVF failure in non-male infertility.

Author

P. Cohen-Bacrie, F. Miyara, F-X. Aubriot, P. Debey, A. Glissant, C. Nathan, S. Douard, A. Stanovici, F. Herve, M. Dumont-Hassan, and A.L. Meur

Subjects
*CHROMATIN, *ZYGOTES, *FERTILIZATION in vitro, *FERTILIZATION (Biology)
Abstract

BACKGROUND: Using fluorescence imaging, an a posteriori multiparametric analysis was performed of human oocytes which failed to give pronucleated zygotes after IVF in cases of very low rates of fertilization or complete fertilization failure. METHODS: The analysis included: (i) the state of the maternal and paternal chromatin; (ii) quality of the metaphase II oocytes; and (iii) cortical granule (CG) distribution. RESULTS: Most oocytes were arrested in metaphase II, but they were abnormal in 50% of cases. The incidence of spindle and chromosome aberrations was strongly influenced by maternal age (69% for 40- to 45-year-old women versus 35% for 26- to 33-year-olds), and sperm chromatin was always condensed in immature oocytes, and fully decondensed only in normal metaphase II. The migration of CGs appeared to be associated with achievement of nuclear maturation at the time of puncture. CONCLUSIONS: These factors, when analysed on a complete set of oocytes from the same patient, provided information about potential causes of IVF failure, and also represented part of an 'oocyte quality evaluation' to select the assisted fertilization technique most suitable for each patient. For example, when the majority of oocytes were judged non-fertilizable at a first attempt, no pregnancy was registered at any subsequent attempt. [ABSTRACT FROM AUTHOR]

Published
2003

40. Diagnosis of Tuberculosis by Trained African Giant Pouched Rats and Confounding Impact of Pathogens and Microflora of the Respiratory Tract

Author

Mgode, Georgies F., Weetjens, Bart J., Nawrath, Thorben, Cox, Christophe, Jubitana, Maureen, Machang'u, Robert S., Cohen-Bacrie, Stéphan, Bedotto, Marielle, Drancourt, Michel, Schulz, Stefan, and Kaufmann, Stefan H. E.

Abstract

ABSTRACTTrained African giant-pouched rats (Cricetomys gambianus) can detect Mycobacterium tuberculosisand show potential for the diagnosis of tuberculosis (TB). However, rats' ability to discriminate between clinical sputum containing other Mycobacteriumspp. and nonmycobacterial species of the respiratory tract is unknown. It is also unknown whether nonmycobacterial species produce odor similar to M. tuberculosisand thereby cause the detection of smear-negative sputum. Sputum samples from 289 subjects were analyzed by smear microscopy, culture, and rats. Mycobacteriumspp. were isolated on Lowenstein-Jensen medium, and nonmycobacterial species were isolated on four different media. The odor from nonmycobacterial species from smear- and M. tuberculosisculture-negative sputa detected by =2 rats (“rat positive”) was analyzed by gas chromatography-mass spectrometry and compared to the M. tuberculosisodor. Rats detected 45 of 56 confirmed cases of TB, 4 of 5 suspected cases of TB, and 63 of 228 TB-negative subjects (sensitivity, 80.4%; specificity, 72.4%; accuracy, 73.9%; positive predictive value, 41.7%; negative predictive value, 93.8%). A total of 37 (78.7%) of 47 mycobacterial isolates were M. tuberculosiscomplex, with 75.7% from rat-positive sputa. Ten isolates were nontuberculous mycobacteria, one was M. intracellulare, one was M. aviumsubsp. hominissuis, and eight were unidentified. Rat-positive sputa with Moraxella catarrhalis, Streptococcus pneumoniae, Staphylococcusspp., and Enterococcusspp. were associated with TB. Rhodococcus, Nocardia, Streptomyces, Staphylococcus, and Candidaspp. from rat-positive sputa did not produce M. tuberculosis-specific volatiles (methyl nicotinate, methyl para-anisate, and ortho-phenylanisole). Prevalence of Mycobacterium-related Nocardiaand Rhodococcusin smear-negative sputa did not equal that of smear-negative mycobacteria (44.7%), of which 28.6% were rat positive. These findings and the absence of M. tuberculosis-specific volatiles in nonmycobacterial species indicate that rats can be trained to specifically detect M. tuberculosis.

Published
2012
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41. Embryology. Embryos with high implantation potential after intracytoplasmic sperm injection can be recognized by a simple, non-invasive examination of pronuclear morphology

Author

Tesarik, J., Junca, A.M., Hazout, A., Aubriot, F.X., Nathan, C., Cohen-Bacrie, P., and Dumont-Hassan, M.

Abstract

Embryos are conventionally selected for transfer based on the evaluation of the cleavage speed and extent of blastomere fragmentation. Here we examined whether the predictive value of these criteria, as indicators of the chance of embryo implantation, can be further potentiated by adding previously described criteria reflecting the regularity of pronuclear development. In a group of embryos selected for transfer in 380 fresh embryo transfer cycles according to the conventional criteria, the transfer of only those embryos that developed from zygotes judged normal at the pronuclear stage (pattern 0) gave significantly higher pregnancy (44.8%) and implantation (30.2%) rates compared with the pregnancy (22.1%; P < 0.05) and implantation rates (11.2%; P < 0.001) for the transfers of only those embryos that developed from zygotes judged abnormal (non-pattern 0). The transfer of only one pattern 0 embryo was sufficient for the optimal chance of pregnancy (no differences in pregnancy rates after transfer of one, two or three pattern 0 embryos), whereas the transfer of two pattern 0 embryos mostly resulted in a twin pregnancy. The inclusion of the criteria based on pronuclear morphology can thus lead to the application of a single embryo transfer policy and optimize the selection of embryos for transfer and cryopreservation.

Published
2000

42. Embryos with high implantation potential after intracytoplasmic sperm injection can be recognized by a simple, non-invasive examination of pronuclear morphology.

Author

Tesarik, J, Junca, A M, Hazout, A, Aubriot, F X, Nathan, C, Cohen-Bacrie, P, and Dumont-Hassan, M

Abstract

Embryos are conventionally selected for transfer based on the evaluation of the cleavage speed and extent of blastomere fragmentation. Here we examined whether the predictive value of these criteria, as indicators of the chance of embryo implantation, can be further potentiated by adding previously described criteria reflecting the regularity of pronuclear development. In a group of embryos selected for transfer in 380 fresh embryo transfer cycles according to the conventional criteria, the transfer of only those embryos that developed from zygotes judged normal at the pronuclear stage (pattern 0) gave significantly higher pregnancy (44.8%) and implantation (30.2%) rates compared with the pregnancy (22.1%; P < 0. 05) and implantation rates (11.2%; P < 0.001) for the transfers of only those embryos that developed from zygotes judged abnormal (non-pattern 0). The transfer of only one pattern 0 embryo was sufficient for the optimal chance of pregnancy (no differences in pregnancy rates after transfer of one, two or three pattern 0 embryos), whereas the transfer of two pattern 0 embryos mostly resulted in a twin pregnancy. The inclusion of the criteria based on pronuclear morphology can thus lead to the application of a single embryo transfer policy and optimize the selection of embryos for transfer and cryopreservation.

Published
2000
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43. Differentiation of spermatogenic cells during in-vitro culture of testicular biopsy samples from patients with obstructive azoospermia: effect of recombinant follicle stimulating hormone

Author

Tesarik, J, Greco, E, Rienzi, L, Ubaldi, F, Guido, M, Cohen-Bacrie, P, and Mendoza, C

Abstract

In-vitro differentiation of spermatogenic cells is a potential approach to the treatment of male sterility due to spermatogenic arrest. This is a pilot study evaluating meiotic, morphogenetic and cytoplasmic maturation of spermatogenic cells from 18 patients with obstructive azoospermia, during in-vitro culture of partly disintegrated testicular biopsy samples in the presence or absence of recombinant follicle stimulating hormone (rFSH). Meiotic progression was detectable only in the presence of rFSH in culture medium. FSH-dependent condensation, peripheral migration and protrusion of spermatid nuclei, together with FSH-independent flagellar growth, were the main events indicating post-meiotic sperm cell differentiation. rFSH also promoted the progression of spermatid cytoplasmic maturation, reflected by acceleration of acrosomal development. These differentiation events appeared to be mediated by humoral activity of Sertoli cells, without the need for a direct Sertoli-sperm cell contact. These findings provide a background for similar studies in patients with non-obstructive azoospermia. If reproducible in the latter group, transmeiotic in-vitro differentiation of primary spermatocytes may be useful in cases of complete maturation arrest, whereas the development of culture-specific forms may help select viable spermatids in cases of complete spermiogenesis failure.Keywords:in-vitro spermatogenesis/recombinant FSH/spermatids/spermatocytes/spermiogenesis

Published
1998

47. Methylation changes in mature sperm deoxyribonucleic acid from oligozoospermic men: assessment of genetic variants and assisted reproductive technology outcome.

Author

Montjean D, Ravel C, Benkhalifa M, Cohen-Bacrie P, Berthaut I, Bashamboo A, and McElreavey K

Subjects
Case-Control Studies, Chi-Square Distribution, Chromosomes, Human, Y, DNA (Cytosine-5-)-Methyltransferases genetics, DNA Methyltransferase 3A, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Male, Odds Ratio, Oligospermia diagnosis, Oligospermia physiopathology, Oligospermia therapy, Phenotype, Pregnancy, Pregnancy Rate, Proteins genetics, RNA, Long Noncoding genetics, Risk Factors, Spermatozoa pathology, Treatment Outcome, DNA metabolism, DNA Methylation, Fertility, Genetic Variation, Oligospermia genetics, Reproductive Techniques, Assisted, Spermatozoa metabolism
Abstract

Objective: To characterize a potential genetic cause for methylation errors described in oligozoospermia., Design: Analysis of PEG1/MEST-DMR and H19-DMR methylation level in sperm, in parallel with the study of several genes on the Y chromosome, DNMT3A, and DNMT3L. Clinical outcome was also looked at regarding PEG1/MEST-DMR and H19-DMR methylation level in sperm., Setting: Research and diagnostic laboratories., Patient(s): One hundred nineteen normospermic and 175 oligozoospermic men consulting for couple infertility., Intervention(s): We studied PEG1/MEST-DMR and H19-DMR methylation profiles in 294 men. We searched for Y chromosome gene aberrations and for mutations in both DNMT3A and DNMT3L genes in men showing epimutations. Assisted reproductive technology (ART) outcomes were also investigated., Main Outcome Measure(s): Sperm samples were collected from 294 volunteers for genomic DNA isolation that was used to study methylation profiles in imprinted loci and Y chromosome SMCY, DNMT3A, and DNMT3L genes. Pregnancy rate was also studied after ART treatment using sperm showing epimutations., Result(s): Epimutations in H19-DMR and PEG1/MEST-DMR were found in 20% and 3% of oligozoospermic men, respectively. We identified an amino acid change in DNMT3A in one case and in DNMT3L in eight men with altered methylation profiles. No mutations were detected in SMCY or in selected Y chromsome genes. No correlation between ART outcome and epimutations was found., Conclusion(s): We observed epimethylations in spermatozoa of oligozoospermic individuals, but no association was found with genetic variants or in the ART outcome., (Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)

Published
2013
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48. Advantages of the two-step embryo transfer strategy in human IVF/ICSI cycles.

Author

Yazbeck C, Ben Jamaa N, Hazout A, Cohen-Bacrie P, Junca AM, and Rougier N

Subjects
Adult, Blastocyst physiology, Cryopreservation, Female, Humans, Live Birth epidemiology, Ovulation Induction, Pregnancy, Pregnancy Rate, Pregnancy, Multiple, Sperm Injections, Intracytoplasmic, Embryo Transfer methods, Fertilization in Vitro methods
Abstract

The aim of this study was to evaluate the advantages of the two-step embryo transfer (ET) strategy combining a day 2/3 ET with a day 5/6 blastocyst transfer. In an observational comparative study, 400 infertile women were enrolled from two assisted reproductive technology (ART) units according to inclusion criteria: age below 42 years and at least three embryos obtained on day 2 thus allowing an extended in vitro culture. Two groups were defined according to the ET strategy adopted: group 1 had a two-step ET; and group 2 had a day 2/3 ET with (subgroup 2a) or without (subgroup 2b) blastocysts cryopreserved on day 5/6. Live birth rate was significantly higher in group 1 than in subgroups 2a and 2b (36.5% versus 29.4% and 13.4%, respectively; p < 10(-3)). Multiple pregnancy rates were comparable between groups. After adjusting on major prognostic factors, the two-step ET strategy was still associated with a significantly higher live birth rate than the day 2/3 ET (OR = 2.23; 95% CI: 1.32-3.77). The two-step ET provides better live birth rates than the cleavage-stage ET. It does not increase multiple pregnancy rates if the number of embryos transferred is limited. It also prevents cycle loss when embryos fail to develop into blastocysts.

Published
2013
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49. Blood type and ovarian reserve.

Author

de Mouzon J, Hazout A, Cohen-Bacrie M, Belloc S, and Cohen-Bacrie P

Subjects
Female, Humans, ABO Blood-Group System, Blood Grouping and Crossmatching, Ovary physiology
Published
2012
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50. [Teratozoospermia, myth or reality? A 10-years retrospective study on 101404 consecutive sperm samples].

Author

Prisant N, Cohen-Bacrie P, Amar E, Belaisch-Allart J, Cohen-Bacrie M, Olivennes F, Aubriot FX, and Belloc S

Subjects
Adult, Humans, Hydrogen-Ion Concentration, Male, Retrospective Studies, Semen Analysis, Sperm Count, Sperm Head ultrastructure, Sperm Motility, Spermatozoa physiology, Spermatozoa abnormalities
Abstract

Objectives: Several studies have reported a time-related decline in semen quality. In this context, 101,404 spermograms-spermocytograms performed in a single andrology laboratory from January 2000 to December 2009 were investigated retrospectively. Variations of sperm parameters were analyzed over the years., Patients and Methods: For each semen sample, age at semen collection, duration of sexual abstinence, volume of seminal fluid, pH, concentration of spermatozoa, percentages of overall motile and progressive motile sperm, percentage of morphologically abnormal spermatozoa (according to David's classification) and amplitude of lateral head displacement (ALH) were analyzed. For each parameter, the mean value per year was determined. To examine trends over time the statistical tests used were analyses of variance and correlation studies., Results: Data showed an increasing age of patients from 36.5 years in 2000 to 37.2 years in 2009. The semen concentration was 63.5 millions/mL in 2000 and 63.6 millions/mL in 2009 with a slight fall from 2001 to 2008. The vitality continuously increased from 67.8% in 2000 to 73.5% in 2009 as well as the overall motility (from 37.7% to 39.2%) and the progressive motility (from 34.6% to 36.2%). The percentage of morphologically abnormal spermatozoa continuously increased from 64.5% to 84.2% (r=0.43, P<0.001)., Discussion and Conclusion: Contrary to a variety of works, our very large study of semen analysis did not show a real decline in semen WHO parameters during a 10-year period, except for the percentage of morphologically abnormal spermatozoa, which dramatically increased over the years., (Copyright © 2010 Elsevier Masson SAS. All rights reserved.)

Published
2011
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