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BackgroundPoor affect recognition is an early sign of frontotemporal dementia (FTD). Here, we applied the abbreviated version of the Comprehensive Affect Testing System (CATS-A) battery to Italian FTD cases and healthy controls (HC) to provide cut-offs of emotional dysfunction in the whole group and in different FTD clinical syndromes.MethodsOne hundred thirty-nine FTD patients (60 behavioural variant [bvFTD],13 semantic behavioural variant of FTD [sbvFTD], 28 progressive supranuclear palsy [PSP], 21 semantic [svPPA] and 17 nonfluent [nfvPPA] variants of primary progressive aphasia) and 116 HC were administered the CATS-A, yielding an Affective Recognition Quotient (ARQ), which was used as outcome measure. Age- and education-adjusted, regression-based norms were derived in HC. In patients, the ARQ was assessed for its internal reliability, factorial validity and construct validity by testing its association with another social cognition paradigm, the Story-Based Empath Task (SET). The diagnostic accuracy of the ARQ in discriminating patients from HC, genetic cases from HC and patient groups among each other was tested via ROC analyses.ResultsIn the whole FTD cohort, CATS-A proved to be underpinned by a mono-component factor (51.1%) and was internally consistent (McDonalds ω = 0.76). Moreover, the ARQ converged with the SET (r(122) = 0.50; p

BackgroundPosterior cortical atrophy is a rare syndrome characterised by early, prominent, and progressive impairment in visuoperceptual and visuospatial processing. The disorder has been associated with underlying neuropathological features of Alzheimer's disease, but large-scale biomarker and neuropathological studies are scarce. We aimed to describe demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy in a large international cohort.MethodsWe searched PubMed between database inception and Aug 1, 2021, for all published research studies on posterior cortical atrophy and related terms. We identified research centres from these studies and requested deidentified, individual participant data (published and unpublished) that had been obtained at the first diagnostic visit from the corresponding authors of the studies or heads of the research centres. Inclusion criteria were a clinical diagnosis of posterior cortical atrophy as defined by the local centre and availability of Alzheimer's disease biomarkers (PET or CSF), or a diagnosis made at autopsy. Not all individuals with posterior cortical atrophy fulfilled consensus criteria, being diagnosed using centre-specific procedures or before development of consensus criteria. We obtained demographic, clinical, biofluid, neuroimaging, and neuropathological data. Mean values for continuous variables were combined using the inverse variance meta-analysis method; only research centres with more than one participant for a variable were included. Pooled proportions were calculated for binary variables using a restricted maximum likelihood model. Heterogeneity was quantified using I2.FindingsWe identified 55 research centres from 1353 papers, with 29 centres responding to our request. An additional seven centres were recruited by advertising via the Alzheimer's Association. We obtained data for 1092 individuals who were evaluated at 36 research centres in 16 countries, the other sites having not responded to our initial invitation to participate to the study. Mean age at symptom onset was 59·4 years (95% CI 58·9-59·8; I2=77%), 60% (56-64; I2=35%) were women, and 80% (72-89; I2=98%) presented with posterior cortical atrophy pure syndrome. Amyloid β in CSF (536 participants from 28 centres) was positive in 81% (95% CI 75-87; I2=78%), whereas phosphorylated tau in CSF (503 participants from 29 centres) was positive in 65% (56-75; I2=87%). Amyloid-PET (299 participants from 24 centres) was positive in 94% (95% CI 90-97; I2=15%), whereas tau-PET (170 participants from 13 centres) was positive in 97% (93-100; I2=12%). At autopsy (145 participants from 13 centres), the most frequent neuropathological diagnosis was Alzheimer's disease (94%, 95% CI 90-97; I2=0%), with common co-pathologies of cerebral amyloid angiopathy (71%, 54-88; I2=89%), Lewy body disease (44%, 25-62; I2=77%), and cerebrovascular injury (42%, 24-60; I2=88%).InterpretationThese data indicate that posterior cortical atrophy typically presents as a pure, young-onset dementia syndrome that is highly specific for underlying Alzheimer's disease pathology. Further work is needed to understand what drives cognitive vulnerability and progression rates by investigating the contribution of sex, genetics, premorbid cognitive strengths and weaknesses, and brain network integrity.FundingNone.

The Cluster multi-point mission offers a unique collection of non-thermal continuum (NTC) radio waves observed in the 2–80 kHz frequency range over almost 15 years, from various view points over the radiating plasmasphere. Here we present rather infrequent case events, such as when primary electrostatic sources of such waves are embedded within the plasmapause boundary far from the magnetic equatorial plane. The spectral signature of the emitted electromagnetic waves is structured as a series of wide harmonic bands within the range covered by the step in plasma frequency encountered at the boundary. Developing the concept that the frequency distance df between harmonic bands measures the magnetic field magnitude B at the source (df = Fce, electron gyrofrequency), we analyse three selected events. The first one (studied in Grimald et al., 2008) presents electric field signatures observed by a Cluster constellation of small size (~ 200 to 1000 km spacecraft separation) placed in the vicinity of sources. The electric field frequency spectra display frequency peaks placed at frequencies fs = n df (n being an integer), with df of the order of Fce values encountered at the plasmapause by the spacecraft. The second event, taken from the Cluster tilt campaign, leads to a 3-D view of NTC waves ray path orientations and to a localization of a global source region at several Earth radii (RE) from Cluster (Décréau et al., 2013). The measured spectra present successive peaks placed at fs ~ (n+ 1/2) df. Next, considering if both situations might be two facets of the same phenomenon, we analyze a third event. The Cluster fleet, configured into a constellation of large size (~ 8000 to 25 000 km spacecraft separation), allows us to observe wide-banded NTC waves at different distances from their sources. Two new findings can be derived from our analysis. First, we point out that a large portion of the plasmasphere boundary layer, covering a large range of magnetic latitudes, is radiating radio waves. The radio waves are issued from multiple sources of small size, each related to a given fs series and radiating inside a beam of narrow cone angle, referred to as a beamlet. The beamlets illuminate different satellites simultaneously, at different characteristic fs values, according to the latitude at which the satellite is placed. Second, when an observing satellite moves away from its assumed source region (the plasmapause surface), it is illuminated by several beamlets, issued from nearby sources with characteristic fs values close to each other. The addition of radio waves blurs the spectra of the overall received electric field. It can move the signal peaks such that their position fs satisfiesfs = (n+α) df, with 0 < α < 1. These findings open new perspectives for the interpretation of NTC events displaying harmonic signatures.

The main part of the Cluster Spatio-Temporal Analysis of Field Fluctuations (STAFF) experiment consists of triaxial search coils allowing the measurements of the three magnetic components of the waves from 0.1 Hz up to 4 kHz. Two sets of data are produced, one by a module to filter and transmit the corresponding waveform up to either 10 or 180 Hz (STAFF-SC), and the second by the onboard Spectrum Analyser (STAFF-SA) to compute the elements of the spectral matrix for five components of the waves, 3 × B and 2 × E (from the EFW experiment), in the frequency range 8 Hz to 4 kHz. In order to understand the way the output signals of the search coils are calibrated, the transfer functions of the different parts of the instrument are described as well as the way to transform telemetry data into physical units across various coordinate systems from the spinning sensors to a fixed and known frame. The instrument sensitivity is discussed. Cross-calibration inside STAFF (SC and SA) is presented. Results of cross-calibration between the STAFF search coils and the Cluster Fluxgate Magnetometer (FGM) data are discussed. It is shown that these cross-calibrations lead to an agreement between both data sets at low frequency within a 2% error. By means of statistics done over 10 yr, it is shown that the functionalities and characteristics of both instruments have not changed during this period.

Objective: Executive Functioning (EF) is a construct that is considered central to cognitive development and has recently garnered attention for its potential role in social functioning. This study investigated the relationship between EF and social skill using both multiple regression and relative weights analyses. Participants: A sample of undergraduate college students in the U.S. (N = 257; N[subscript female] = 145; M[subscript age] = 19.51) participated for course credit. Methods: Participants completed an online survey. Data were analyzed using multiple regression and relative weights analysis to better understand the unique contribution of EF skills to specific social skills. Results: For some dimensions of EF, ability positively correlated with adaptive social outcome, whereas for some other dimensions, "lower" ability correlated with positive social outcomes. Conclusions: EF may play a role in the general social functioning of college students, though the relationship appears complex and domain-specific.

ADHD symptoms in emerging adult college students are associated with multiple impairments. Social support may buffer the relation between ADHD and impairment. Social support can be defined in terms of quantity or quality; more research is needed to better understand this distinction. Thus, the current study examined the moderating effect of social support quantity vs. quality on the relation between ADHD symptoms and impairment in college students. Our sample included 2,517 undergraduate students (75% women) in the United States who participated in an online survey. In a series of moderated regression analyses, we found that social support quantity (i.e. having a larger social network) served as a buffer of impairment, while social support quality (i.e. the depth and availability of individuals in the social circle) did not. This suggests that college students with ADHD symptoms may need to spread their social support needs among a larger group of people to receive the support they need. Clinically, college counseling centers should be aware of this, and tailor their interventions accordingly. Limitations and future directions are discussed.

The Cluster mission operated a "tilt campaign" during the month of May 2008. Two of the four identical Cluster spacecraft were placed at a close distance (~50 km) from each other and the spin axis of one of the spacecraft pair was tilted by an angle of ~46°. This gave the opportunity, for the first time in space, to measure global characteristics of AC electric field, at the sensitivity available with long boom (88 m) antennas, simultaneously from the specific configuration of the tilted pair of satellites and from the available base of three satellites placed at a large characteristic separation (~1 RE). This paper describes how global characteristics of radio waves, in this case the configuration of the electric field polarization ellipse in 3-D-space, are identified from in situ measurements of spin modulation features by the tilted pair, validating a novel experimental concept. In the event selected for analysis, non-thermal continuum (NTC) waves in the 15–25 kHz frequency range are observed from the Cluster constellation placed above the polar cap. The observed intensity variations with spin angle are those of plane waves, with an electric field polarization close to circular, at an ellipticity ratio e = 0.87. We derive the source position in 3-D by two different methods. The first one uses ray path orientation (measured by the tilted pair) combined with spectral signature of magnetic field magnitude at source. The second one is obtained via triangulation from the three spacecraft baseline, using estimation of directivity angles under assumption of circular polarization. The two results are not compatible, placing sources widely apart. We present a general study of the level of systematic errors due to the assumption of circular polarization, linked to the second approach, and show how this approach can lead to poor triangulation and wrong source positioning. The estimation derived from the first method places the NTC source region in the dawn sector, at a large L value (L ~ 10) and a medium geomagnetic latitude (35° S). We discuss these untypical results within the frame of the geophysical conditions prevailing that day, i.e. a particularly quiet long time interval, followed by a short increase of magnetic activity.

The frequency range of the WHISPER relaxation sounder instrument on board CLUSTER, 4–80 kHz, has been chosen so as to encompass the electron gyro-frequency, Fce, and the electron plasma frequency, Fp, in most regions to be explored. Measurement of those frequencies, which are triggered as resonances by the sounder, provides a direct estimation of in situ fundamental plasma characteristics: electron density and magnetic field intensity. In the late mission phase, CLUSTER penetrated regions deep inside the plasmasphere where Fce and Fp are much higher than the upper frequency of the sounder's range. However, they are of the right order of magnitude as to place the lower hybrid frequency, Flh, in the 4–15 kHz band. This characteristic frequency, placed at a resonance of the medium, is triggered by the sounder's transmitter and shows up as an isolated peak in the received spectrum, not present in spectra of naturally occuring VLF waves. This paper illustrates, from analysis of case events, how measured Flh values give access to a plasma diagnostic novel of its kind. CLUSTER, travelling along its orbit, encounters favourable conditions where Fce is increasing and Fp decreasing, such that Fce/Fp increases from values below unity to values above unity. Measured Flh values thus give access, in turn, to the effective mass, Meff, indicative of plasma ion composition, and to the core plasmasphere electron density value, a parameter difficult to measure. The analysed case events indicate that the estimated quantities (Meff in the 1.0–1.4 range, Ne in the 5 × 102–104 cm−3 range) are varying with external factors (altitude, L value, geomagnetic activity) in a plausible way. Although covering only a restricted region (mid-latitude, low altitude inner plasmasphere), these measurements are available, since late 2009, for all CLUSTER perigee passes not affected by eclipses (on average, roughly a third of a total of ~200 passes per year) and offer multipoint observations previously unavailable in this region.

We present data from the sixth Cassini flyby of Titan (T5), showing that the magnetosphere of Saturn strongly interacts with the moon's ionosphere and exo-ionosphere. A simple electron ionisation model provides a reasonable agreement with the altitude structure of the ionosphere. Furthermore, we suggest that the dense and cold exo-ionosphere (from the exobase at 1430 km and outward to several Titan radii from the surface) can be explained by magnetospheric forcing and other transport processes whereas exospheric ionisation by impacting low energy electrons seems to play a minor role.

Above the polar cap, at about 5–9 Earth radii (RE) altitude, the PEACE experiment onboard CLUSTER detected, for the first time, electron beams outflowing from the ionosphere with large and variable energy fluxes, well collimated along the magnetic field lines. All these events occurred during periods of northward or weak interplanetary magnetic field (IMF). These outflowing beams were generally detected below 100 eV and typically between 40 and 70 eV, just above the photoelectron level. Their energy gain can be explained by the presence of a field-aligned potential drop below the spacecraft, as in the auroral zone. The careful analysis of the beams distribution function indicates that they were not only accelerated but also heated. The parallel heating is estimated to about 2 to 20 eV and it globally tends to increase with the acceleration energy. Moreover, WHISPER observed broadband electrostatic emissions around a few kHz correlated with the outflowing electron beams, which suggests beam-plasma interactions capable of triggering plasma instabilities. In presence of simultaneous very weak ion fluxes, the outflowing electron beams are the main carriers of downward field-aligned currents estimated to about 10 nA/m2. These electron beams are actually not isolated but surrounded by wider structures of ion outflows. All along its polar cap crossings, Cluster observed successive electron and ion outflows. This implies that the polar ionosphere represents a significant source of cold plasma for the magnetosphere during northward or weak IMF conditions. The successive ion and electron outflows finally result in a filamented current system of opposite polarities which connects the polar ionosphere to distant regions of the magnetosphere.

Non-thermal continuum (NTC) radiation is, with auroral kilometric radiation (AKR), one of the two electromagnetic emissions generated within the Earth's magnetosphere and radiated into space. The location of the source of NTC has been sought for several decades, with only limited success. The constellation formed by the four CLUSTER spacecraft provides the possibility of triangulation in the vicinity of the source, thus allowing progress in source localisation, while simultaneously revealing the beaming properties of NTC radio sources. We present a case event showing two beams localised on opposite sides of the magnetic equator. At any selected frequency, triangulation points to a single region source of small size. Its position is compatible with the range of possible loci of sources predicted by the radio window theory of Jones (1982) in a frame of constraints relaxed from the simple sketch proposed in early works. The analysis of similar observations from the Dynamics Explorer 1 by Jones et al. (1987) enabled the authors to claim validation of the radio window theory. CLUSTER observations, however, reveal a large beaming cone angle projected onto the ecliptic plane, a feature unobservable by Dynamics Explorer which had a different spin axis orientation. According to the radio window theory, such a large observed cone angle can only be formed by a series of point sources, each beaming in a narrow cone angle. This study demonstrates the difficulty of validating NTC linear generation mechanisms using global beaming properties alone.

Plasmaspheric plumes have been routinely observed by CLUSTER and IMAGE. The CLUSTER mission provides high time resolution four-point measurements of the plasmasphere near perigee. Total electron density profiles have been derived from the electron plasma frequency identified by the WHISPER sounder supplemented, in-between soundings, by relative variations of the spacecraft potential measured by the electric field instrument EFW; ion velocity is also measured onboard these satellites. The EUV imager onboard the IMAGE spacecraft provides global images of the plasmasphere with a spatial resolution of 0.1 RE every 10 min; such images acquired near apogee from high above the pole show the geometry of plasmaspheric plumes, their evolution and motion. We present coordinated observations of three plume events and compare CLUSTER in-situ data with global images of the plasmasphere obtained by IMAGE. In particular, we study the geometry and the orientation of plasmaspheric plumes by using four-point analysis methods. We compare several aspects of plume motion as determined by different methods: (i) inner and outer plume boundary velocity calculated from time delays of this boundary as observed by the wave experiment WHISPER on the four spacecraft, (ii) drift velocity measured by the electron drift instrument EDI onboard CLUSTER and (iii) global velocity determined from successive EUV images. These different techniques consistently indicate that plasmaspheric plumes rotate around the Earth, with their foot fully co-rotating, but with their tip rotating slower and moving farther out.

Electromagnetic low-frequency waves in the magnetotail lobe close to the PSBL (Plasma Sheet Boundary Layer) are studied using the Cluster spacecraft. The lobe waves show Alfvénic properties and transport their wave energy (Poynting flux) on average toward the Earth along magnetic field lines. Most of the wave events are rich with oxygen (O+) ion plasma. The rich O+ plasma can serve to enhance the magnetic field fluctuations, resulting in a greater likelihood of observation, but it does not appear to be necessary for the generation of the waves. Taking into account the fact that all events are associated with auroral electrojet enhancements, the source of the lobe waves might be a substorm-associated instability, i.e. some instability near the reconnection site, or an ion beam-related instability in the PSBL.

The electron density profiles derived from the EFW and WHISPER instruments on board the four Cluster spacecraft reveal density structures inside the plasmasphere and at its outer boundary, the plasmapause. We have conducted a statistical study to characterize these density structures. We focus on the plasmasphere crossing on 11 April 2002, during which Cluster observed several density irregularities inside the plasmasphere, as well as a plasmaspheric plume. We derive the density gradient vectors from simultaneous density measurements by the four spacecraft. We also determine the normal velocity of the boundaries of the plume and of the irregularities from the time delays between those boundaries in the four individual density profiles, assuming they are planar. These new observations yield novel insights about the occurrence of density irregularities, their geometry and their dynamics. These in-situ measurements are compared with global images of the plasmasphere from the EUV imager on board the IMAGE satellite.

It is now well known that amplitude modulated HF transmissions into the ionosphere can be used to generate ELF/VLF signals using the so-called "electrojet antenna". Although most observations of the generated ELF/VLF signals have been made on the ground, several low and high-altitude satellite observations have also been reported (James et al., 1990). One of the important unknowns in the physics of ELF/VLF wave generation by ionospheric heating is the volume of the magnetosphere illuminated by the ELF/VLF waves. In an attempt to investigate this question further, ground-satellite conjunction experiments have recently been conducted using the four Cluster satellites and the HF heater of the High-Frequency Active Auroral Research Program (HAARP) facility in Gakona, Alaska. Being located on largely closed field lines at L≈4.9, HAARP is currently also being used for ground-to-ground type of ELF/VLF wave-injection experiments, and will be increasingly used for this purpose as it is now being upgraded for higher power operation. In this paper, we describe the HAARP installation and present recent results of the HAARP-Cluster experiments. We give an overview of the detected ELF/VLF signals at Cluster, and a possible explanation of the spectral signature detected, as well as the determination of the location of the point of injection of the HAARP ELF/VLF signals into the magnetosphere using ray tracing.

The Cluster fleet offers the first possibility of comparing non-thermal terrestrial continuum radiation from similarly equipped nearby observation points. A very rich data set has already been acquired on the Cluster polar orbit, between 4 and 19 Earth radii geocentric distances, and preliminary analysis has been carried out on these emissions. We focus in this paper on direction finding performed from all four spacecraft as a means to locate the position of the sources of this continuum radiation. Directions are derived from spin modulation properties, under the usual analysis assumptions of the wave vector of the radiation lying in the plane containing the spin axis and the antenna position at electric field minimum. All the spin axes of the four Cluster spacecraft are aligned perpendicular to the ecliptic, thus the aligned spacecraft antenna spin planes provide redundant 2-D views of the propagation path of the radiation and source location. Convincing 2-D triangulation results have been obtained in the vicinity of the source region. In addition, the out of spin plane component of the wave vector reveals itself to a certain extent through directivity characteristics compared at different distances of the spin plane to the ecliptic. The four case events studied (two of them taken near apogee, the other two near perigee) have confirmed general properties derived from previous observations: trapping in the lower frequency range, radiation escaping into the magnetosheath region in the higher frequency range. All propagation directions are compatible with source positions in the plasmapause region, however, at a significant distance from the equator in one case. Our observations have also revealed new properties, like the importance of small-scale density irregularities in the local amplification of continuum radiation. We conclude that more detailed generation and propagation models are needed to fit the observations.

The Spatio Temporal Analysis of Field Fluctuations (STAFF) experiment is one of the five experiments, which constitute the Cluster Wave Experiment Consortium (WEC). STAFF consists of a three-axis search coil magnetometer to measure magnetic fluctuations at frequencies up to 4 kHz, a waveform unit (up to either 10 Hz or 180 Hz) and a Spectrum Analyser (up to 4 kHz). The Spectrum Analyser combines the 3 magnetic components of the waves with the two electric components measured by the Electric Fields and Waves experiment (EFW) to calculate in real time the 5 × 5 Hermitian cross-spectral matrix at 27 frequencies distributed logarithmically in the frequency range 8 Hz to 4 kHz. The time resolution varies between 0.125 s and 4 s. The first results show the capabilities of the experiment, with examples in different regions of the magnetosphere-solar wind system that were encountered by Cluster at the beginning of its operational phase. First results obtained by the use of some of the tools that have been prepared specifically for the Cluster mission are described. The characterisation of the motion of the bow shock between successive crossings, using the reciprocal vector method, is given. The full characterisation of the waves analysed by the Spectrum Analyser, thanks to a dedicated program called PRASSADCO, is applied to some events; in particular a case of very confined electromagnetic waves in the vicinity of the equatorial region is presented and discussed.Key words. Magnetospheric physics (magnetopause, cusp and boundary layer) – Space plasma physics (waves and instabilities; shock waves)

We present the study of one of the first magnetopause crossings observed by the four Cluster spacecraft simultaneously, on 10 December 2000. Although the delays between the crossings are very short, the features of the boundary appear quite different as seen by the different spacecraft, strongly suggesting the presence of a local curvature of the magnetopause at that time. The small-scale fluctuations observed by the STAFF search-coil experiment are placed in relation to this context. A preliminary investigation of their behaviour on the boundary and in the neighbourhood magnetosheath is performed in comparison with the theoretical model of Belmont and Rezeau (2001), which describes the interaction of waves with the boundary.Key words. Space plasma physics (transport processes, discontinuities, turbulence)

The Wave Experiment Consortium, WEC, is a highly integrated package of five instruments used to study the plasma environment around the Earth. One of these instruments, the Waves of HIgh frequency and Sounder for Probing of Electron density by Relaxation, Whisper, aims at the thermal electron density evaluation and natural wave monitoring in the 4–83 kHz frequency range. In its active working mode, which is our primarily concern here, the Whisper instrument transmits a short wave train at a swept frequency and receives echoes after a delay. Incidentally, it behaves like a classical ground-based ionosonde. Natural modes of oscillations may thus be excited in the surrounding medium. This means that with suitable interpretations, the Whisper sounding technique becomes a powerful tool for plasma diagnosis. By taking into account the characteristic frequencies of the magnetoplasmas encountered by the Cluster spacecraft, it is indeed possible to reliably and accurately determine the electron density and, to a lesser degree, the magnetic field strength from the Whisper electric field measurements. Due to the predominantly electrostatic nature of the waves that are excited, observations of resonances may also lead to information on the electron velocity distribution functions. The existence of a hot population may indeed be revealed and the hot to cold density ratio can be estimated.Key words. Magnetospheric physics (plasma waves and instabilities). Space plasma physics (active perturbation experiments; instruments and techniques)