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3. PLANES EXPERIMENTALES PARA MEDIR LA INCIDENCIA DE VARIABLES TECNOLÓGICAS EN LOS INDICADORES DE UNA INVERSIÓN

Author

Lester A. Alemán Hurtado, Binko Mamady Toure, Yoelvis Fleites Avila, Yailet Albernas Carvajal, and Erenio González Suárez

Subjects
diseños experimentales, incertidumbre, indicadores económicos, inversión, tecnología, Special industries and trades, HD9000-9999
Abstract

Introducción: Como la incertidumbre incide en los indicadores económicos de las instalaciones una vez hecha la inversión, se propone cuantificar cada variable tecnológica, con ayuda de diseños experimentales para trabajar en minimizarla. Objetivo: Anticipar con rapidez los impactos de la incertidumbre en las variables tecnológicas del diseño de una instalación industrial para definir la estrategia investigativa para introducir la tecnología. Materiales y Métodos: Mediante el conocimiento de una tecnología, se realizaron ensayos teóricos para medir la incidencia de las variables del proceso, en indicadores económicos de seis variantes tecnológicas. Debido al alto número de variables independientes se utilizó una combinación de diseños factoriales parciales para medir la sensibilidad de los indicadores a la desviación de las variables. Resultados y Discusión: De los resultados de costo por litro de etanol y por peso de producción, se determinaron mediante el diseño de Plackett – Bürman, la significación de los coeficientes de las variables para las seis variantes. Descartando las variables no significativas, y reducidos los diseños a factoriales parciales, se identifica la significación de las variables como medida de la incertidumbre y cuales deben investigarse para resolver los problemas que limitan la introducción de las tecnologías. Conclusiones: Aplicando diseños factoriales parciales se definió, con mínimo trabajo experimental, la significación de variables incidentes en los indicadores económicos de las variantes tecnológicas, permitiendo trazar políticas de investigación a fin de minimizar gastos asociados a la tecnología.

Published
2021

5. PLANES EXPERIMENTALES AL ESTUDIAR LA HIDRÓLISIS ÁCIDA DE ASERRÍN DE PINO PARA PRODUCIR ETANOL

Author

Leyanis Mesa Garriga, Erenio González Suárez, Binko Mamady Toure, Nancy López Bello, and Roxana Cortés-Martínez

Subjects
aserrín de pino, diseño de experimento, etanol, hidrólisis, investigaciones, Special industries and trades, HD9000-9999
Abstract

Introducción: Es necesario estudiar las posibilidades de determinar con rapidez y exactitud la obtención de etanol de aserrín de madera de pino, minimizando los gastos experimentales y con ello los costos de investigación para evaluar alternativas en la producción de etanol de residuos lignocelulósicos. Objetivo: Verificar la factibilidad de aplicar los diseños experimentales para conocer las verdaderas potencialidades del aserrín de pino como materia prima para etanol de residuos lignocelulósicos. Materiales y Métodos: La investigación se realizó utilizando diseños de experimentos en la etapa de hidrólisis ácida a nivel de laboratorio, que permitieron evaluar el uso de estos métodos midiendo el efecto de las variables del proceso en los resultados de diferentes azúcares obtenidos. Resultados y Discusión: El comportamiento no lineal del efecto de las variables independientes en la cantidad de glucosa obtenida, por masa seca inicial, en el líquido filtrado de la etapa de fracción ácida de aserrín de pino permite predecir que los mejores resultados de esta variable de respuesta se consiguen a valores altos del por ciento de ácido y de temperatura. Conclusiones: El uso de estrategias experimentales utilizando diseño de experimentos permite obtener resultados técnicos de proyección económica minimizando los gastos de la investigación.

Published
2021

6. The LOFT Ground Segment

Author

Bozzo, E., Antonelli, A., Argan, A., Barret, D., Binko, P., Brandt, S., Cavazzuti, E., Courvoisier, T., Herder, J. W. den, Feroci, M., Ferrigno, C., Giommi, P., Götz, D., Guy, L., Hernanz, M., Zand, J. J. M. in't, Klochkov, D., Kuulkers, E., Motch, C., Lumb, D., Papitto, A., Pittori, C., Rohlfs, R., Santangelo, A., Schmid, C., Schwope, A. D., Smith, P. J., Webb, N. A., Wilms, J., and Zane, S.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

LOFT, the Large Observatory For X-ray Timing, was one of the ESA M3 mission candidates that completed their assessment phase at the end of 2013. LOFT is equipped with two instruments, the Large Area Detector (LAD) and the Wide Field Monitor (WFM). The LAD performs pointed observations of several targets per orbit (~90 minutes), providing roughly ~80 GB of proprietary data per day (the proprietary period will be 12 months). The WFM continuously monitors about 1/3 of the sky at a time and provides data for about ~100 sources a day, resulting in a total of ~20 GB of additional telemetry. The LOFT Burst alert System additionally identifies on-board bright impulsive events (e.g., Gamma-ray Bursts, GRBs) and broadcasts the corresponding position and trigger time to the ground using a dedicated system of ~15 VHF receivers. All WFM data are planned to be made public immediately. In this contribution we summarize the planned organization of the LOFT ground segment (GS), as established in the mission Yellow Book 1 . We describe the expected GS contributions from ESA and the LOFT consortium. A review is provided of the planned LOFT data products and the details of the data flow, archiving and distribution. Despite LOFT was not selected for launch within the M3 call, its long assessment phase (> 2 years) led to a very solid mission design and an efficient planning of its ground operations., Comment: Proc. SPIE 9144, Space Telescopes and Instrumentation 2014: Ultraviolet to Gamma Ray, 91446A

Published
2014
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7. The Large Observatory For x-ray Timing

Author

Feroci, M., Herder, J. W. den, Bozzo, E., Barret, D., Brandt, S., Hernanz, M., van der Klis, M., Pohl, M., Santangelo, A., Stella, L., Watts, A., Wilms, J., Zane, S., Ahangarianabhari, M., Albertus, C., Alford, M., Alpar, A., Altamirano, D., Alvarez, L., Amati, L., Amoros, C., Andersson, N., Antonelli, A., Argan, A., Artigue, R., Artigues, B., Atteia, J. -L., Azzarello, P., Bakala, P., Baldazzi, G., Balman, S., Barbera, M., van Baren, C., Bhattacharyya, S., Baykal, A., Belloni, T., Bernardini, F., Bertuccio, G., Bianchi, S., Bianchini, A., Binko, P., Blay, P., Bocchino, F., Bodin, P., Bombaci, I., Bidaud, J. -M. Bonnet, Boutloukos, S., Bradley, L., Braga, J., Brown, E., Bucciantini, N., Burderi, L., Burgay, M., Bursa, M., Budtz-Jørgensen, C., Cackett, E., Cadoux, F. R., Cais, P., Caliandro, G. A., Campana, R., Campana, S., Capitanio, F., Casares, J., Casella, P., Castro-Tirado, A. J., Cavazzuti, E., Cerda-Duran, P., Chakrabarty, D., Château, F., Chenevez, J., Coker, J., Cole, R., Collura, A., Cornelisse, R., Courvoisier, T., Cros, A., Cumming, A., Cusumano, G., D'Aì, A., D'Elia, V., Del Monte, E., De Luca, A., De Martino, D., Dercksen, J. P. C., De Pasquale, M., De Rosa, A., Del Santo, M., Di Cosimo, S., Diebold, S., Di Salvo, T., Donnarumma, I., Drago, A., Durant, M., Emmanoulopoulos, D., Erkut, M. H., Esposito, P., Evangelista, Y., Fabian, A., Falanga, M., Favre, Y., Feldman, C., Ferrari, V., Ferrigno, C., Finger, M., Finger, M. H., Fraser, G. W., Frericks, M., Fuschino, F., Gabler, M., Galloway, D. K., Sanchez, J. L. Galvez, Garcia-Berro, E., Gendre, B., Gezari, S., Giles, A. B., Gilfanov, M., Giommi, P., Giovannini, G., Giroletti, M., Gogus, E., Goldwurm, A., Goluchová, K., Götz, D., Gouiffes, C., Grassi, M., Groot, P., Gschwender, M., Gualtieri, L., Guidorzi, C., Guy, L., Haas, D., Haensel, P., Hailey, M., Hansen, F., Hartmann, D. H., Haswell, C. A., Hebeler, K., Heger, A., Hermsen, W., Homan, J., Hornstrup, A., Hudec, R., Huovelin, J., Ingram, A., Zand, J. J. M. in't, Israel, G., Iwasawa, K., Izzo, L., Jacobs, H. M., Jetter, F., Johannsen, T., Jonker, P., Josè, J., Kaaret, P., Kanbach, G., Karas, V., Karelin, D., Kataria, D., Keek, L., Kennedy, T., Klochkov, D., Kluzniak, W., Kokkotas, K., Korpela, S., Kouveliotou, C., Kreykenbohm, I., Kuiper, L. M., Kuvvetli, I., Labanti, C., Lai, D., Lamb, F. K., Laubert, P. P., Lebrun, F., Lin, D., Linder, D., Lodato, G., Longo, F., Lund, N., Maccarone, T. J., Macera, D., Maestre, S., Mahmoodifar, S., Maier, D., Malcovati, P., Mandel, I., Mangano, V., Manousakis, A., Marisaldi, M., Markowitz, A., Martindale, A., Matt, G., McHardy, I. M., Melatos, A., Mendez, M., Mereghetti, S., Michalska, M., Migliari, S., Mignani, R., Miller, M. C., Miller, J. M., Mineo, T., Miniutti, G., Morsink, S., Motch, C., Motta, S., Mouchet, M., Mouret, G., Mulačová, J., Muleri, F., Muñoz-Darias, T., Negueruela, I., Neilsen, J., Norton, A. J., Nowak, M., O'Brien, P., Olsen, P. E. H., Orienti, M., Orio, M., Orlandini, M., Orleanski, P., Osborne, J. P., Osten, R., Ozel, F., Pacciani, L., Paolillo, M., Papitto, A., Paredes, J. M., Patruno, A., Paul, B., Perinati, E., Pellizzoni, A., Penacchioni, A. V., Perez, M. A., Petracek, V., Pittori, C., Pons, J., Portell, J., Possenti, A., Poutanen, J., Prakash, M., Provost, P. Le, Psaltis, D., Rambaud, D., Ramon, P., Ramsay, G., Rapisarda, M., Rachevski, A., Rashevskaya, I., Ray, P. S., Rea, N., Reddy, S., Reig, P., Aranda, M. Reina, Remillard, R., Reynolds, C., Rezzolla, L., Ribo, M., de la Rie, R., Riggio, A., Rios, A., Gil, P. Rodríguez, Rodriguez, J., Rohlfs, R., Romano, P., Rossi, E. M. R., Rozanska, A., Rousseau, A., Ryde, F., Sabau-Graziati, L., Sala, G., Salvaterra, R., Sanna, A., Sandberg, J., Scaringi, S., Schanne, S., Schee, J., Schmid, C., Shore, S., Schneider, R., Schwenk, A., Schwope, A. D., Seyler, J. -Y., Shearer, A., Smith, A., Smith, D. M., Smith, P. J., Sochora, V., Soffitta, P., Soleri, P., Spencer, A., Stappers, B., Steiner, A. W., Stergioulas, N., Stratta, G., Strohmayer, T. E., Stuchlik, Z., Suchy, S., Sulemainov, V., Takahashi, T., Tamburini, F., Tauris, T., Tenzer, C., Tolos, L., Tombesi, F., Tomsick, J., Torok, G., Torrejon, J. M., Torres, D. F., Tramacere, A., Trois, A., Turolla, R., Turriziani, S., Uter, P., Uttley, P., Vacchi, A., Varniere, P., Vaughan, S., Vercellone, S., Vrba, V., Walton, D., Watanabe, S., Wawrzaszek, R., Webb, N., Weinberg, N., Wende, H., Wheatley, P., Wijers, R., Wijnands, R., Wille, M., Wilson-Hodge, C. A., Winter, B., Wood, K., Zampa, G., Zampa, N., Zampieri, L., Zdunik, L., Zdziarski, A., Zhang, B., Zwart, F., Ayre, M., Boenke, T., van Damme, C. Corral, Kuulkers, E., and Lumb, D.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The Large Observatory For x-ray Timing (LOFT) was studied within ESA M3 Cosmic Vision framework and participated in the final down-selection for a launch slot in 2022-2024. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument, LOFT will study the behaviour of matter under extreme conditions, such as the strong gravitational field in the innermost regions of accretion flows close to black holes and neutron stars, and the supra-nuclear densities in the interior of neutron stars. The science payload is based on a Large Area Detector (LAD, 10 m 2 effective area, 2-30 keV, 240 eV spectral resolution, 1 deg collimated field of view) and a WideField Monitor (WFM, 2-50 keV, 4 steradian field of view, 1 arcmin source location accuracy, 300 eV spectral resolution). The WFM is equipped with an on-board system for bright events (e.g. GRB) localization. The trigger time and position of these events are broadcast to the ground within 30 s from discovery. In this paper we present the status of the mission at the end of its Phase A study., Comment: Proc. SPIE 9144, Space Telescopes and Instrumentation 2014: Ultraviolet to Gamma Ray, 91442T

Published
2014
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8. Planck Early Results. V. The Low Frequency Instrument data processing

Author

Zacchei, A., Maino, D., Baccigalupi, C., Bersanelli, M., Bonaldi, A., Bonavera, L., Burigana, C., Butler, R. C., Cuttaia, F., de Zotti, G., Dick, J., Frailis, M., Galeotta, S., González-Nuevo, J., Górski, K. M., Gregorio, A., Keihänen, E., Keskitalo, R., Knoche, J., Kurki-Suonio, H., Lawrence, C. R., Leach, S., Leahy, J. P., López-Caniego, M., Mandolesi, N., Maris, M., Matthai, F., Meinhold, P. R., Mennella, A., Morgante, G., Morisset, N., Natoli, P., Pasian, F., Perrotta, F., Polenta, G., Poutanen, T., Reinecke, M., Ricciardi, S., Rohlfs, R., Sandri, M., Suur-Uski, A. -S., Tauber, J. A., Tavagnacco, D., Terenzi, L., Tomasi, M., Valiviita, J., Villa, F., Zonca, A., Banday, A. J., Barreiro, R. B., Bartlett, J. G., Bartolo, N., Bedini, L., Bennett, K., Binko, P., Borrill, J., Bouchet, F. R., Bremer, M., Cabella, P., Cappellini, B., Chen, X., Colombo, L., Cruz, M., Curto, A., Danese, L., Davies, R. D., Davis, R. J., de Gasperis, G., de Rosa, A., de Troia, G., Dickinson, C., Diego, J. M., Donzelli, S., Dörl, U., Efstathiou, G., Enßlin, T. A., Eriksen, H. K., Falvella, M. C., Finelli, F., Franceschi, E., Gaier, T. C., Gasparo, F., Génova-Santos, R. T., Giardino, G., Gómez, F., Gruppuso, A., Hansen, F. K., Hell, R., Herranz, D., Hovest, W., Huynh, M., Jewell, J., Juvela, M., Kisner, T. S., Knox, L., Lähteenmäki, A., Lamarre, J. -M., Leonardi, R., León-Tavares, J., Lilje, P. B., Lubin, P. M., Maggio, G., Marinucci, D., Martínez-González, E., Massardi, M., Matarrese, S., Meharga, M. T., Melchiorri, A., Migliaccio, M., Mitra, S., Moss, A., Nørgaard-Nielsen, H. U., Pagano, L., Paladini, R., Paoletti, D., Partridge, B., Pearson, D., Pettorino, V., Pietrobon, D., Prézeau, G., Procopio, P., Puget, J. -L., Quercellini, C., Rachen, J. P., Rebolo, R., Robbers, G., Rocha, G., Rubiño-Martín, J. A., Salerno, E., Savelainen, M., Scott, D., Seiffert, M. D., Silk, J. I., Smoot, G. F., Sternberg, J., Stivoli, F., Stompor, R., Tofani, G., Toffolatti, L., Tuovinen, J., Türler, M., Umana, G., Vielva, P., Vittorio, N., Vuerli, C., Wade, L. A., Watson, R., White, S. D. M., and Wilkinson, A.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We describe the processing of data from the Low Frequency Instrument (LFI) used in production of the Planck Early Release Compact Source Catalogue (ERCSC). In particular, we discuss the steps involved in reducing the data from telemetry packets to cleaned, calibrated, time-ordered data (TOD) and frequency maps. Data are continuously calibrated using the modulation of the temperature of the cosmic microwave background radiation induced by the motion of the spacecraft. Noise properties are estimated from TOD from which the sky signal has been removed using a generalized least square map-making algorithm. Measured 1/f noise knee-frequencies range from 100mHz at 30GHz to a few tens of mHz at 70GHz. A destriping code (Madam) is employed to combine radiometric data and pointing information into sky maps, minimizing the variance of correlated noise. Noise covariance matrices required to compute statistical uncertainties on LFI and Planck products are also produced. Main beams are estimated down to the approx -10dB level using Jupiter transits, which are also used for geometrical calibration of the focal plane., Comment: A&A Volume 536, December 2011 Planck early results

Published
2011
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9. A systematic approach to the Planck LFI end-to-end test and its application to the DPC Level 1 pipeline

Author

Frailis, M., Maris, M., Zacchei, A., Morisset, N., Rohlfs, R., Meharga, M., Binko, P., Turler, M., Galeotta, S., Gasparo, F., Franceschi, E., Butler, R. C., D'Arcangelo, O., Fogliani, S., Gregorio, A., Lowe, S. R., Maggio, G., Malaspina, M., Mandolesi, N., Manzato, P., Pasian, F., Perrotta, F., Sandri, M., Terenzi, L., Tomasi, M., and Zonca, A.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Extragalactic Astrophysics
Abstract

The Level 1 of the Planck LFI Data Processing Centre (DPC) is devoted to the handling of the scientific and housekeeping telemetry. It is a critical component of the Planck ground segment which has to strictly commit to the project schedule to be ready for the launch and flight operations. In order to guarantee the quality necessary to achieve the objectives of the Planck mission, the design and development of the Level 1 software has followed the ESA Software Engineering Standards. A fundamental step in the software life cycle is the Verification and Validation of the software. The purpose of this work is to show an example of procedures, test development and analysis successfully applied to a key software project of an ESA mission. We present the end-to-end validation tests performed on the Level 1 of the LFI-DPC, by detailing the methods used and the results obtained. Different approaches have been used to test the scientific and housekeeping data processing. Scientific data processing has been tested by injecting signals with known properties directly into the acquisition electronics, in order to generate a test dataset of real telemetry data and reproduce as much as possible nominal conditions. For the HK telemetry processing, validation software have been developed to inject known parameter values into a set of real housekeeping packets and perform a comparison with the corresponding timelines generated by the Level 1. With the proposed validation and verification procedure, where the on-board and ground processing are viewed as a single pipeline, we demonstrated that the scientific and housekeeping processing of the Planck-LFI raw data is correct and meets the project requirements., Comment: 20 pages, 7 figures; this paper is part of the Prelaunch status LFI papers published on JINST: http://www.iop.org/EJ/journal/-page=extra.proc5/jinst

Published
2010
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10. LFI Radiometric Chain Assembly (RCA) data handling 'Rachel'

Author

Malaspina, M., Franceschi, E., Battaglia, P., Binko, P., Butler, R. C., D'Arcangelo, O., Fogliani, S., Frailis, M., Franceschet, C., Galeotta, S., Gasparo, F., Gregorio, A., Lapolla, M., Leonardi, R., Maggio, G., Mandolesi, N., Manzato, P., Maris, M., Meharga, M., Meinhold, P., Morisset, N., Pasian, F., Perrotta, F., Rohlfs, R., Sandri, M., Tomasi, M., Turler, M., Zacchei, A., and Zonca, A.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

This paper is part of the Prelaunch status LFI papers published on JINST (http://www.iop.org/EJ/journal/-page=extra.proc5/1748-0221). Planck's Low Frequency Instrument is an array of 22 pseudo-correlation radiometers at 30, 44, and 70 GHz. Before integrating the overall array assembly, a first set of tests has been performed for each radiometer chain assembly (RCA), consisting of two radiometers. In this paper, we describe Rachel, a software application which has been purposely developed and used during the RCA test campaign to carry out both near-realtime on-line data analysis and data storage (in FITS format) of the raw output from the radiometric chains., Comment: This is an author-created, un-copyedited version of an article accepted for publication in JINST. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The definitive publisher authenticated version is available online at http://dx.doi.org/10.1088/1748-0221/4/12/T12017

Published
2010
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11. Level 1 on-ground telemetry handling in Planck LFI

Author

Zacchei, A., Frailis, M., Maris, M., Morisset, N., Rohlfs, R., Meharga, M., Binko, P., Turler, M., Galeotta, S., Gasparo, F., Franceschi, E., Butler, R. C., Cuttaia, F., D'Arcangelo, O., Fogliani, S., Gregorio, A., Leonardi, R., Lowe, S. R., Maino, D., Maggio, G., Malaspina, M., Mandolesi, N., Manzato, P., Meinhold, P., Mendes, L., Mennella, A., Morgante, G., Pasian, F., Perrotta, F., Sandri, M., Stringhetti, L., Terenzi, L., Tomasi, M., and Zonca, A.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Extragalactic Astrophysics
Abstract

The Planck Low Frequency Instrument (LFI) will observe the Cosmic Microwave Background (CMB) by covering the frequency range 30-70 GHz in three bands. The primary instrument data source are the temperature samples acquired by the 22 radiometers mounted on the Planck focal plane. Such samples represent the scientific data of LFI. In addition, the LFI instrument generates the so called housekeeping data by sampling regularly the on-board sensors and registers. The housekeeping data provides information on the overall health status of the instrument and on the scientific data quality. The scientific and housekeeping data are collected on-board into telemetry packets compliant with the ESA Packet Telemetry standards. They represent the primary input to the first processing level of the LFI Data Processing Centre. In this work we show the software systems which build the LFI Level 1. A real-time assessment system, based on the ESA SCOS 2000 generic mission control system, has the main purpose of monitoring the housekeeping parameters of LFI and detect possible anomalies. A telemetry handler system processes the housekeeping and scientific telemetry of LFI, generating timelines for each acquisition chain and each housekeeping parameter. Such timelines represent the main input to the subsequent processing levels of the LFI DPC. A telemetry quick-look system allows the real-time visualization of the LFI scientific and housekeeping data, by also calculating quick statistical functions and fast Fourier transforms. The LFI Level 1 has been designed to support all the mission phases, from the instrument ground tests and calibration to the flight operations, and developed according to the ESA engineering standards., Comment: This paper is part of the Prelaunch status LFI papers published on JINST: http://www.iop.org/EJ/journal/-page=extra.proc5/jinst

Published
2010
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12. Off-line radiometric analysis of Planck/LFI data

Author

Tomasi, M., Mennella, A., Galeotta, S., Lowe, S. R., Mendes, L., Leonardi, R., Villa, F., Cappellini, B., Gregorio, A., Meinhold, P., Sandri, M., Cuttaia, F., Terenzi, L., Maris, M., Valenziano, L., Salmon, M. J., Bersanelli, M., Binko, P., Butler, R. C., D'Arcangelo, O., Fogliani, S., Frailis, M., Franceschi, E., Gasparo, F., Maggio, G., Maino, D., Malaspina, M., Mandolesi, N., Manzato, P., Meharga, M., Morgante, G., Morisset, N., Pasian, F., Perrotta, F., Rohlfs, R., Turler, M., Zacchei, A., and Zonca, A.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Extragalactic Astrophysics
Abstract

The Planck Low Frequency Instrument (LFI) is an array of 22 pseudo-correlation radiometers on-board the Planck satellite to measure temperature and polarization anisotropies in the Cosmic Microwave Background (CMB) in three frequency bands (30, 44 and 70 GHz). To calibrate and verify the performances of the LFI, a software suite named LIFE has been developed. Its aims are to provide a common platform to use for analyzing the results of the tests performed on the single components of the instrument (RCAs, Radiometric Chain Assemblies) and on the integrated Radiometric Array Assembly (RAA). Moreover, its analysis tools are designed to be used during the flight as well to produce periodic reports on the status of the instrument. The LIFE suite has been developed using a multi-layered, cross-platform approach. It implements a number of analysis modules written in RSI IDL, each accessing the data through a portable and heavily optimized library of functions written in C and C++. One of the most important features of LIFE is its ability to run the same data analysis codes both using ground test data and real flight data as input. The LIFE software suite has been successfully used during the RCA/RAA tests and the Planck Integrated System Tests. Moreover, the software has also passed the verification for its in-flight use during the System Operations Verification Tests, held in October 2008., Comment: Planck LFI technical papers published by JINST: http://www.iop.org/EJ/journal/-page=extra.proc5/1748-0221

Published
2010
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13. Optimization of Planck/LFI on--board data handling

Author

Maris, M., Tomasi, M., Galeotta, S., Miccolis, M., Hildebrandt, S., Frailis, M., Rohlfs, R., Morisset, N., Zacchei, A., Bersanelli, M., Binko, P., Burigana, C., Butler, R. C., Cuttaia, F., Chulani, H., D'Arcangelo, O., Fogliani, S., Franceschi, E., Gasparo, F., Gomez, F., Gregorio, A., Herreros, J. M., Leonardi, R., Leutenegger, P., Maggio, G., Maino, D., Malaspina, M., Mandolesi, N., Manzato, P., Meharga, M., Meinhold, P., Mennella, A., Pasian, F., Perrotta, F., Rebolo, R., Turler, M., and Zonca, A.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics, Computer Science - Information Theory
Abstract

To asses stability against 1/f noise, the Low Frequency Instrument (LFI) onboard the Planck mission will acquire data at a rate much higher than the data rate allowed by its telemetry bandwith of 35.5 kbps. The data are processed by an onboard pipeline, followed onground by a reversing step. This paper illustrates the LFI scientific onboard processing to fit the allowed datarate. This is a lossy process tuned by using a set of 5 parameters Naver, r1, r2, q, O for each of the 44 LFI detectors. The paper quantifies the level of distortion introduced by the onboard processing, EpsilonQ, as a function of these parameters. It describes the method of optimizing the onboard processing chain. The tuning procedure is based on a optimization algorithm applied to unprocessed and uncompressed raw data provided either by simulations, prelaunch tests or data taken from LFI operating in diagnostic mode. All the needed optimization steps are performed by an automated tool, OCA2, which ends with optimized parameters and produces a set of statistical indicators, among them the compression rate Cr and EpsilonQ. For Planck/LFI the requirements are Cr = 2.4 and EpsilonQ <= 10% of the rms of the instrumental white noise. To speedup the process an analytical model is developed that is able to extract most of the relevant information on EpsilonQ and Cr as a function of the signal statistics and the processing parameters. This model will be of interest for the instrument data analysis. The method was applied during ground tests when the instrument was operating in conditions representative of flight. Optimized parameters were obtained and the performance has been verified, the required data rate of 35.5 Kbps has been achieved while keeping EpsilonQ at a level of 3.8% of white noise rms well within the requirements., Comment: 51 pages, 13 fig.s, 3 tables, pdflatex, needs JINST.csl, graphicx, txfonts, rotating; Issue 1.0 10 nov 2009; Sub. to JINST 23Jun09, Accepted 10Nov09, Pub.: 29Dec09; This is a preprint, not the final version

Published
2010
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14. The Large Observatory for x-ray timing

Author

Feroci, M, Herder, JW den, Bozzo, E, Barret, D, Brandt, S, Hernanz, M, van der Klis, M, Pohl, M, Santangelo, A, Stella, L, Watts, A, Wilms, J, Zane, S, Ahangarianabhari, M, Albertus, C, Alford, M, Alpar, A, Altamirano, D, Alvarez, L, Amati, L, Amoros, C, Andersson, N, Antonelli, A, Argan, A, Artigue, R, Artigues, B, Atteia, J-L, Azzarello, P, Bakala, P, Baldazzi, G, Balman, S, Barbera, M, van Baren, C, Bhattacharyya, S, Baykal, A, Belloni, T, Bernardini, F, Bertuccio, G, Bianchi, S, Bianchini, A, Binko, P, Blay, P, Bocchino, F, Bodin, P, Bombaci, I, Bidaud, J-M Bonnet, Boutloukos, S, Bradley, L, Braga, J, Brown, E, Bucciantini, N, Burderi, L, Burgay, M, Bursa, M, Budtz-Jørgensen, C, Cackett, E, Cadoux, FR, Caïs, P, Caliandro, GA, Campana, R, Campana, S, Capitanio, F, Casares, J, Casella, P, Castro-Tirado, AJ, Cavazzuti, E, Cerda-Duran, P, Chakrabarty, D, Château, F, Chenevez, J, Coker, J, Cole, R, Collura, A, Cornelisse, R, Courvoisier, T, Cros, A, Cumming, A, Cusumano, G, D'Ai, A, D'Elia, V, Del Monte, E, de Luca, A, de Martino, D, Dercksen, JPC, de Pasquale, M, De Rosa, A, Del Santo, M, Di Cosimo, S, Diebold, S, Di Salvo, T, Donnarumma, I, Drago, A, Durant, M, Emmanoulopoulos, D, Erkut, MH, Esposito, P, Evangelista, Y, Fabian, A, Falanga, M, and Favre, Y

Subjects
X-ray timing, X-ray spectroscopy, X-ray imaging, compact objects, X-ray detectors, microchannel plates, astro-ph.IM
Abstract

The Large Observatory For x-ray Timing (LOFT) was studied within ESA M3 Cosmic Vision framework and participated in the final downselection for a launch slot in 2022-2024. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument, LOFT will study the behaviour of matter under extreme conditions, such as the strong gravitational field in the innermost regions of accretion flows close to black holes and neutron stars, and the supranuclear densities in the interior of neutron stars. The science payload is based on a Large Area Detector (LAD, 10 m2 effective area, 2-30 keV, 240 eV spectral resolution, 1° collimated field of view) and a Wide Field Monitor (WFM, 2-50 keV, 4 steradian field of view, 1 arcmin source location accuracy, 300 eV spectral resolution). The WFM is equipped with an on-board system for bright events (e.g. GRB) localization. The trigger time and position of these events are broadcast to the ground within 30 s from discovery. In this paper we present the status of the mission at the end of its Phase A study.

Published
2014

15. Assigning mitochondrial localization of dual localized proteins using a yeast Bi-Genomic Mitochondrial-Split-GFP

Author

Gaétan Bader, Ludovic Enkler, Yuhei Araiso, Marine Hemmerle, Krystyna Binko, Emilia Baranowska, Johan-Owen De Craene, Julie Ruer-Laventie, Jean Pieters, Déborah Tribouillard-Tanvier, Bruno Senger, Jean-Paul di Rago, Sylvie Friant, Roza Kucharczyk, and Hubert Dominique Becker

Subjects
mitochondria, dual localized protein, Split-GFP, import, aminoacyl-tRNA synthetase, argonaute 2 protein, Medicine, Science, Biology (General), QH301-705.5
Abstract

A single nuclear gene can be translated into a dual localized protein that distributes between the cytosol and mitochondria. Accumulating evidences show that mitoproteomes contain lots of these dual localized proteins termed echoforms. Unraveling the existence of mitochondrial echoforms using current GFP (Green Fluorescent Protein) fusion microscopy approaches is extremely difficult because the GFP signal of the cytosolic echoform will almost inevitably mask that of the mitochondrial echoform. We therefore engineered a yeast strain expressing a new type of Split-GFP that we termed Bi-Genomic Mitochondrial-Split-GFP (BiG Mito-Split-GFP). Because one moiety of the GFP is translated from the mitochondrial machinery while the other is fused to the nuclear-encoded protein of interest translated in the cytosol, the self-reassembly of this Bi-Genomic-encoded Split-GFP is confined to mitochondria. We could authenticate the mitochondrial importability of any protein or echoform from yeast, but also from other organisms such as the human Argonaute 2 mitochondrial echoform.

Published
2020
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16. Slightly elevated international normalized ratio predicts bleeding episodes in patients treated with direct oral anticoagulants

Author

Priya Bhardwaj, Louise Breum Petersen, Tomas Sorm Binko, Jan Roland Petersen, and Gitte Gleerup Fornitz

Subjects
Medicine (General), R5-920
Abstract

Introduction Patients treated with direct oral anticoagulants (DOACs) are at increased bleeding risk. It is therefore of increasing interest to identify predictors of bleeding episodes to increase safety during treatment with DOACs. Methods This retrospective cohort study systematically reviewed medical records of 235 patients treated with either apixaban, rivaroxaban or dabigatran for non-valvular atrial fibrillation or venous thromboembolism and collected data on the international normalized ratio (INR) and all bleeding episodes. Results INR ≥ 1.5 was significantly associated with increased risk of minor and major bleeding events in patients treated with direct factor Xa inhibitors. This association was not present in patients treated with dabigatran. However, a high negative predictive value was identified for INR

Published
2020
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17. Inductive Reasoning in the Secondary Classroom.

Author

National Education Association, Washington, DC., Neubert, Gloria A., and Binko, James B.

Abstract

It has been alleged that few American students can use their knowledge effectively in thinking and reasoning. This study urges teachers to give more attention to student abilities in analyzing, classifying, comparing, formulating hypotheses, and drawing conclusions--that is, thinking skills essential to reasoning processes. Designed to familiarize secondary classroom teachers with one model of instruction for developing students' reasoning abilities, this book gives practical assistance in learning how to use the inductive approach, a teaching approach that actively involves students in the use of their own reasoning while learning content area material. Each chapter of the book includes a section that asks readers to recall experience pertinent to the material in the chapter, a set of questions to answer as the material is read, and a series of activities designed to lead readers through the developmental stages of the learning process. Chapters of the book are: (1) What is the inductive approach? (2) Why use the inductive approach? (3) How to use the inductive approach for concept development; (4) How to use the inductive approach for principle formation; (5) Inductive reasoning in English; (6) Inductive reasoning in mathematics; (7) Inductive reasoning in science; and (8) Inductive reasoning in social studies. A 90-item bibliography is attached. (RS)

Published
1992

18. Deficits in integrative NMDA receptors caused by Grin1disruption can be rescued in adulthood

Author

Venkatesan, Sridevi, Binko, Mary A., Mielnik, Catharine A., Ramsey, Amy J., and Lambe, Evelyn K.

Abstract

Glutamatergic NMDA receptors (NMDAR) are critical for cognitive function, and their reduced expression leads to intellectual disability. Since subpopulations of NMDARs exist in distinct subcellular environments, their functioning may be unevenly vulnerable to genetic disruption. Here, we investigate synaptic and extrasynaptic NMDARs on the major output neurons of the prefrontal cortex in mice deficient for the obligate NMDAR subunit encoded by Grin1and wild-type littermates. With whole-cell recording in brain slices, we find that single, low-intensity stimuli elicit surprisingly-similar glutamatergic synaptic currents in both genotypes. By contrast, clear genotype differences emerge with manipulations that recruit extrasynaptic NMDARs, including stronger, repetitive, or pharmacological stimulation. These results reveal a disproportionate functional deficit of extrasynaptic NMDARs compared to their synaptic counterparts. To probe the repercussions of this deficit, we examine an NMDAR-dependent phenomenon considered a building block of cognitive integration, basal dendrite plateau potentials. Since we find this phenomenon is readily evoked in wild-type but not in Grin1-deficient mice, we ask whether plateau potentials can be restored by an adult intervention to increase Grin1expression. This genetic manipulation, previously shown to restore cognitive performance in adulthood, successfully rescues electrically-evoked basal dendrite plateau potentials after a lifetime of NMDAR compromise. Taken together, our work demonstrates NMDAR subpopulations are not uniformly vulnerable to the genetic disruption of their obligate subunit. Furthermore, the window for functional rescue of the more-sensitive integrative NMDARs remains open into adulthood.

Published
2023
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19. Adolescent Girls' Perceptions of Smoking Risk and Protective Factors: Implications for Message Design

Author

Curbow, Barbara, Bowie, Janice, and Binko, JoAnn

Abstract

Using a snowball technique, in-depth interviews were conducted with 108 girls emanating from seven demographically dissimilar social networks. Girls were asked to classify 58 items as either a risk or protective factor for smoking initiation and then to assign an importance weighting to each. All items except one (worries about her weight) were clearly categorized as risk or protective; mean levels of agreement were 80.8% for perceived risk items and 92.6% for perceived protective items. Principal components analysis (PCA) of the weights given to the perceived risk items found that 28 items loaded on seven factors (social, affect, access, media, offers, family, and image) and explained 71.26% of the variance. PCA of 25 protective items revealed four factors (health, family, looks, and barriers) that explained 73.35% of the variance. Significant group differences on the importance weights were found, primarily by school (public or private), age (12-14 years or 15-16 years), having a friend who smokes (yes or no), and having tried smoking (yes or no). These group differences support the idea of having a broader array of antismoking messages for adolescent girls so that important subgroups can be targeted. Additional results support the position of developing antismoking messages with positive, affirming themes.

Published
2007
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21. Writing and Geography Provide Lessons for Other Disciplines.

Author

Binko, James B., Neubert, Gloria A., and Madden, Maggie

Abstract

The National Writing Project and the National Geographic Society's Geography Education Program are two highly acclaimed staff development networks that are models for other organizations. Both programs feature intensive summer workshops and numerous followups during the subsequent school year. This paper describes the networks and presents six recommendations for staff developers. (SM)

Published
1997

22. Teaching Geography in the Disciplines. Fastback No. 400.

Author

Phi Delta Kappa Educational Foundation, Bloomington, IN., Binko, James B., and Neubert, Gloria A.

Abstract

This booklet provides an overview of interdisciplinary geography and supplies practical examples of how geography can be linked to other subjects. Because geography is included in new state high school graduation requirements, the subject is making a renaissance in the classroom. Teachers are finding new and exciting ways to integrate geography into existing courses of study, and are revising curricula to incorporate geographic perspectives into other disciplines. The fastback is divided into five sections: (1) "Geography's Renaissance"; (2) "Components of Geographic Understanding"; (3) "Frameworks for Teaching Geography"; (4) "Geography in History and Social Studies"; and (5) "Geography in Other Disciplines." Samples of geographic integration are provided for the subjects of art, English and language arts, foreign language, health, history, mathematics, music, physical education, social studies, and science. Contains 65 references. (EH)

Published
1996

23. Using the Inductive Approach to Construct Content Knowledge.

Author

Neubert, Gloria A. and Binko, James B.

Abstract

Examines the inductive approach to learning, which helps ensure an interactive environment where students use their language processes to learn. Preservice teachers can learn to organize their teaching inductively. Such training should include direct experience with the inductive approach, analysis of the experiences, guided practice, and coaching in field settings. (SM)

Published
1991

24. DISPONIBILIDAD DE BIOMASA COMO FUENTE DE PRODUCTOS QUÍMICOS Y ENERGÍA EN CABINDA, ANGOLA

Author

David Muto Lubota, Gilberto Hernández Pérez, José Fernando B. do Rosario, Binko Mamade Toure, and Julio Pedraza Garciga

Subjects
energía, biomasa residual, bioenergéticos, coproductos, Special industries and trades, HD9000-9999
Abstract

El objetivo del trabajo es determinar la disponibilidad de la biomasa para la producción de bioenergéticos en Cabinda, Angola. Metodológicamente se concibió mediante la investigación, revisión de documentos, observación directa, entrevista, estudio de campo y el análisis llevado a cabo en instituciones, empresas, industrias y áreas de cultivo que constituyen gran fuente de biomasa residual en el territorio de Cabinda. Como principales resultados se presenta un análisis detallado de la disponibilidad de la biomasa agrícola y agroindustrial existente, donde se tiene en cuenta el potencial productivo de la floresta, así como la clasificación de la biomasa, la determinación del potencial uso de sus principales componentes, y la distribución geográfica de la biomasa residual agrícola y agroindustrial para determinar posteriormente las principales alternativas para la producción de energía y productos de mayor valor agregado (etanol, biodiesel, hidrógeno, biogás, bioelectricidad, etc.) a desarrollar en Cabinda, Angola, por tal motivo se concluye que la biomasa residual disponible en Cabinda se clasifica en: residuos forestales, residuos madereros industriales, residuos industriales, suficiente cantidad para ser fuente de productos químicos y energía, constituyendo es estudio la antesala para la estrategia para el aprovechamiento de la biomasa como fuente de productos químicos y energía.

Published
2014

25. INITIAL CAPACITY OF BIOENERGETIC PRODUCTION FOR THE RECYCLING OF PLASTICS IN CABINDA, ANGOLA

Author

David Muto Lubota, Tania Grancho Freitas, Divanize de Jesus Sambovo Landa, Juan Esteban Miño Valdés, and Binko Mamade Toure

Subjects
bioenergetics, initial investments, technology assimilation, uncertainty, plastic, Special industries and trades, HD9000-9999
Abstract

In this paper, the study of the possibilities of the efficient use of forest residuals as raw materials, for the production of bioenergetics that guarantees the operations of a plant for the recycling of plastic residuals is exposed. In the study, a conceptual model and the procedures for the assimilation of technologies of bioenergetic production, reported in previous works, is validated (Muto et al., 2016). Due to their significance, it is considered the uncertainty to the future changes with emphasis to the growth of the demand of capacities of prosecution of urban solid wastes (USW) and the readiness of the raw material. Suitable values of initial investment capabilities are determined for a first step forward so that a second stage investor that increases capabilities must be run at 6 years for initial investment executed capabilities. The first investment will recover in 2.8 years.

Published
2016

26. Winds OF CHANGE.

Author

Biemesderfer, Susan, Binko, Heidi, Spruce, George Blue, Coulon, Kyle, Panza, Alexa, Pollard, D. J., Quinn, Patrick, Rust, Tyler, Singer, Suzanne, Smith, Tiffany D., and Warren, Chris

Subjects
BOARDS of directors, EDITORIAL boards
Published
2023

27. Professional Development Schools--The Proof Is in Performance.

Author

Neubert, Gloria A. and Binko, James B.

Abstract

Facing a new state mandate, Maryland teacher educators established a pilot professional development school (PDS) and achieved positive results with preservice teachers. The PDS internship was more effective than the regular program in preparing teacher candidates to maintain classroom discipline, use technology effectively for instruction, and reflect on their teaching. Also, the PDS provided the participating school with professional development and technical assistance. (MLH)

Published
1998

29. Book reviews

Author

Khan, Badrul, Reigeluth, Charles M., Binko, Julie, Fletcher-Campbell, Felicity, and McArthur, Ian

Published
1992
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33. Teach-Probe-Revise: A Model for Initiating Classroom Research.

Author

Neubert, Gloria A. and Binko, James B.

Abstract

Proposes a model to help teachers become consumers and producers of research as an integral part of classroom instruction. The strategy begins with teachers' concerns and aims at helping them become more responsible for directing their own professional development. Suggests employment of the model in preservice teacher education. (TRS)

Published
1986

34. Geography Inservice that Works: Multiplying Your Successes.

Author

Binko, James B.

Abstract

Based on two premises for successful inservice training (collegiality and peer training capabilities), this article describes four steps for organizing an effective program: awareness, understanding, guided practice, and implementation. The fourth step is more effective when accompanied initially by peer coaching, mentoring, or team teaching. (MLH)

Published
1989

35. Off-line radiometric analysis of Planck/LFI data

Author

F. Gasparo, S. Fogliani, Andrea Zacchei, E. Franceschi, S. Galeotta, Davide Maino, Andrea Zonca, Anna Gregorio, Luca Terenzi, Fabrizio Villa, O. D'Arcangelo, F. Pasian, M. Malaspina, M. Frailis, M. Tomasi, R. C. Butler, N. Morisset, Rodrigo Leonardi, F. Perrotta, F. Cuttaia, Marc Türler, A. Mennella, M. Meharga, Marco Bersanelli, L. Mendes, Gianluca Morgante, R. Rohlfs, P. Manzato, Luca Valenziano, M. Maris, M. J. Salmon, M. Sandri, B. Cappellini, G. Maggio, P. Binko, N. Mandolesi, Peter Meinhold, S. R. Lowe, M., Tomasi, A., Mennella, S., Galeotta, S. R., Lowe, L., Mende, R., Leonardi, F., Villa, B., Cappellini, Gregorio, Anna, P., Meinhold, M., Sandri, F., Cuttaia, L., Terenzi, M., Mari, L., Valenziano, M. J., Salmon, M., Bersanelli, P., Binko, R. C., Butler, O., D'Arcangelo, S., Fogliani, M., Fraili, E., Franceschi, F., Gasparo, G., Maggio, D., Maino, M., Malaspina, N., Mandolesi, P., Manzato, M., Meharga, G., Morgante, N., Morisset, F., Pasian, F., Perrotta, R., Rohlf, M., Türler, and A. ZACCHEI AND A., Zonca

Subjects
Cosmology and Nongalactic Astrophysics (astro-ph.CO), Computer science, Cosmic microwave background, Real-time computing, FOS: Physical sciences, Low frequency, Data Handling, Space instrumentation, Instruments for CM B observations, Instru- mental noise, Radio spectrum, symbols.namesake, Settore FIS/05 - Astronomia e Astrofisica, Instruments for CMB observations, CMB physics, Planck, Instrumental noise, Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM), Mathematical Physics, Radiometer, Planck ESA mission, symbols, Radiometric dating, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The Planck Low Frequency Instrument (LFI) is an array of 22 pseudo-correlation radiometers on-board the Planck satellite to measure temperature and polarization anisotropies in the Cosmic Microwave Background (CMB) in three frequency bands (30, 44 and 70 GHz). To calibrate and verify the performances of the LFI, a software suite named LIFE has been developed. Its aims are to provide a common platform to use for analyzing the results of the tests performed on the single components of the instrument (RCAs, Radiometric Chain Assemblies) and on the integrated Radiometric Array Assembly (RAA). Moreover, its analysis tools are designed to be used during the flight as well to produce periodic reports on the status of the instrument. The LIFE suite has been developed using a multi-layered, cross-platform approach. It implements a number of analysis modules written in RSI IDL, each accessing the data through a portable and heavily optimized library of functions written in C and C++. One of the most important features of LIFE is its ability to run the same data analysis codes both using ground test data and real flight data as input. The LIFE software suite has been successfully used during the RCA/RAA tests and the Planck Integrated System Tests. Moreover, the software has also passed the verification for its in-flight use during the System Operations Verification Tests, held in October 2008., Comment: Planck LFI technical papers published by JINST: http://www.iop.org/EJ/journal/-page=extra.proc5/1748-0221

Published
2010
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36. Optimization of Planck/LFI –on board data handling

Author

Davide Maino, A. Mennella, O. D'Arcangelo, Anna Gregorio, Peter Meinhold, H. Chulani, M. Frailis, N. Morisset, Sergi R. Hildebrandt, José Miguel Herreros, P. Manzato, F. Pasian, S. Fogliani, Rafael Rebolo, Andrea Zonca, F. Gasparo, F. Perrotta, M. Maris, P. Binko, Marc Türler, Andrea Zacchei, P. Leutenegger, Carlo Burigana, M. Meharga, M. Tomasi, N. Mandolesi, M. Malaspina, Marco Bersanelli, R. Rohlfs, M. Miccolis, G. Maggio, F. Cuttaia, Rodrigo Leonardi, R. C. Butler, F. Gomez, E. Franceschi, S. Galeotta, M., Mari, M., Tomasi, S., Galeotta, M., Miccoli, S., Hildebrandt, M., Fraili, R., Rohlf, N., Morisset, A., Zacchei, M., Bersanelli, P., Binko, C., Burigana, R. C., Butler, F., Cuttaia, H., Chulani, O., D'Arcangelo, S., Fogliani, E., Franceschi, F., Gasparo, F., Gomez, Gregorio, Anna, J. M., Herrero, R., Leonardi, P., Leutenegger, G., Maggio, D., Maino, M., Malaspina, N., Mandolesi, P., Manzato, M., Meharga, P., Meinhold, A., Mennella, F., Pasian, F., Perrotta, R., Rebolo, and M. TÜRLER AND A., Zonca

Subjects
FOS: Computer and information sciences, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Computer science, Computer Science - Information Theory, FOS: Physical sciences, Lossy compression, Instruments for CMB observations, Settore FIS/05 - Astronomia e Astrofisica, CMB physics, Electronic engineering, Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM), Mathematical Physics, Instrument Data, Planck ESA mission, Information Theory (cs.IT), Data compression, On-board data handling, Space instrumentation, Detector, Bandwidth (signal processing), Data compression ratio, White noise, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

To asses stability against 1/f noise, the Low Frequency Instrument (LFI) onboard the Planck mission will acquire data at a rate much higher than the data rate allowed by its telemetry bandwith of 35.5 kbps. The data are processed by an onboard pipeline, followed onground by a reversing step. This paper illustrates the LFI scientific onboard processing to fit the allowed datarate. This is a lossy process tuned by using a set of 5 parameters Naver, r1, r2, q, O for each of the 44 LFI detectors. The paper quantifies the level of distortion introduced by the onboard processing, EpsilonQ, as a function of these parameters. It describes the method of optimizing the onboard processing chain. The tuning procedure is based on a optimization algorithm applied to unprocessed and uncompressed raw data provided either by simulations, prelaunch tests or data taken from LFI operating in diagnostic mode. All the needed optimization steps are performed by an automated tool, OCA2, which ends with optimized parameters and produces a set of statistical indicators, among them the compression rate Cr and EpsilonQ. For Planck/LFI the requirements are Cr = 2.4 and EpsilonQ, 51 pages, 13 fig.s, 3 tables, pdflatex, needs JINST.csl, graphicx, txfonts, rotating; Issue 1.0 10 nov 2009; Sub. to JINST 23Jun09, Accepted 10Nov09, Pub.: 29Dec09; This is a preprint, not the final version

Published
2009

37. LFI Radiometric Chain Assembly (RCA) data handling 'Rachel'

Author

Marc Türler, Anna Gregorio, M. Tomasi, F. Gasparo, R. Rohlfs, N. Morisset, F. Pasian, N. Mandolesi, E. Franceschi, Cristian Franceschet, Andrea Zonca, M. Frailis, G. Maggio, F. Perrotta, P. Binko, S. Galeotta, S. Fogliani, M. Lapolla, M. Malaspina, M. Meharga, R. C. Butler, Andrea Zacchei, Rodrigo Leonardi, M. Sandri, P. Battaglia, Peter Meinhold, P. Manzato, M. Maris, O. D'Arcangelo, M., Malaspina, E., Franceschi, P., Battaglia, P., Binko, R. C., Butler, O., D'Arcangelo, S., Fogliani, M., Fraili, C., Franceschet, S., Galeotta, F., Gasparo, Gregorio, Anna, M., Lapolla, R., Leonardi, G., Maggio, N., Mandolesi, P., Manzato, M., Mari, M., Meharga, P., Meinhold, N., Morisset, F., Pasian, F., Perrotta, R., Rohlf, M., Sandri, M., Tomasi, M., Türler, and A. ZACCHEI AND A., Zonca

Subjects
Radiometer, Spectral responses, Computer science, Group method of data handling, Planck ESA mission, CMB physics, Software Engineering, FOS: Physical sciences, Data Handling, Low frequency, Set (abstract data type), symbols.namesake, Settore FIS/05 - Astronomia e Astrofisica, Microwave Antennas, symbols, Radiometric dating, Planck, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM), Mathematical Physics, Remote sensing
Abstract

This paper is part of the Prelaunch status LFI papers published on JINST (http://www.iop.org/EJ/journal/-page=extra.proc5/1748-0221). Planck's Low Frequency Instrument is an array of 22 pseudo-correlation radiometers at 30, 44, and 70 GHz. Before integrating the overall array assembly, a first set of tests has been performed for each radiometer chain assembly (RCA), consisting of two radiometers. In this paper, we describe Rachel, a software application which has been purposely developed and used during the RCA test campaign to carry out both near-realtime on-line data analysis and data storage (in FITS format) of the raw output from the radiometric chains., Comment: This is an author-created, un-copyedited version of an article accepted for publication in JINST. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The definitive publisher authenticated version is available online at http://dx.doi.org/10.1088/1748-0221/4/12/T12017

Published
2009

38. Level 1 on-ground telemetry handling in Planck-LFI

Author

Anna Gregorio, M. Tomasi, P. Binko, M. Frailis, M. Meharga, Gianluca Morgante, F. Gasparo, N. Morisset, R. Rohlfs, N. Mandolesi, S. Fogliani, Andrea Zacchei, Andrea Zonca, Luca Terenzi, L. Mendes, R. C. Butler, Luca Stringhetti, F. Cuttaia, Francesca Perrotta, Rodrigo Leonardi, M. Sandri, G. Maggio, A. Mennella, Marc Türler, E. Franceschi, S. Galeotta, P. Manzato, M. Maris, Davide Maino, O. D'Arcangelo, S. R. Lowe, F. Pasian, Peter Meinhold, M. Malaspina, A., Zacchei, M., Fraili, M., Mari, N., Morisset, R., Rohlf, M., Meharga, P., Binko, M., Türler, S., Galeotta, F., Gasparo, E., Franceschi, R. C., Butler, F., Cuttaia, O., D'Arcangelo, S., Fogliani, Gregorio, Anna, R., Leonardi, S. R., Lowe, D., Maino, G., Maggio, M., Malaspina, N., Mandolesi, P., Manzato, P., Meinhold, L., Mende, A., Mennella, G., Morgante, F., Pasian, F., Perrotta, M., Sandri, L., Stringhetti, L., Terenzi, and M. TOMASI AND A., Zonca

Subjects
Data processing, Mission control center, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Computer science, Instrument Data, Group method of data handling, Planck ESA mission, CMB physics, Real-time computing, Housekeeping (computing), FOS: Physical sciences, Data Handling, Real-time monitoring, Space instrumentation, Settore FIS/05 - Astronomia e Astrofisica, Instruments for CMB observations, Telemetry, Data quality, Software system, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM), Mathematical Physics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

The Planck Low Frequency Instrument (LFI) will observe the Cosmic Microwave Background (CMB) by covering the frequency range 30-70 GHz in three bands. The primary instrument data source are the temperature samples acquired by the 22 radiometers mounted on the Planck focal plane. Such samples represent the scientific data of LFI. In addition, the LFI instrument generates the so called housekeeping data by sampling regularly the on-board sensors and registers. The housekeeping data provides information on the overall health status of the instrument and on the scientific data quality. The scientific and housekeeping data are collected on-board into telemetry packets compliant with the ESA Packet Telemetry standards. They represent the primary input to the first processing level of the LFI Data Processing Centre. In this work we show the software systems which build the LFI Level 1. A real-time assessment system, based on the ESA SCOS 2000 generic mission control system, has the main purpose of monitoring the housekeeping parameters of LFI and detect possible anomalies. A telemetry handler system processes the housekeeping and scientific telemetry of LFI, generating timelines for each acquisition chain and each housekeeping parameter. Such timelines represent the main input to the subsequent processing levels of the LFI DPC. A telemetry quick-look system allows the real-time visualization of the LFI scientific and housekeeping data, by also calculating quick statistical functions and fast Fourier transforms. The LFI Level 1 has been designed to support all the mission phases, from the instrument ground tests and calibration to the flight operations, and developed according to the ESA engineering standards., Comment: This paper is part of the Prelaunch status LFI papers published on JINST: http://www.iop.org/EJ/journal/-page=extra.proc5/jinst

Published
2009
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39. The Large Observatory For x-ray Timing

Author

Antonios Manousakis, S. Boutloukos, F. Zwart, Jose M. Torrejon, C. Pittori, Alessandro Drago, Dieter H. Hartmann, Feryal Özel, T. J. L. Courvoisier, Tim Johannsen, Jordi José, M. Michalska, Christian Schmid, I. Rashevskaya, Gottfried Kanbach, V. Petracek, L. Bradley, Allan Hornstrup, M. H. Erkut, Sergio Campana, Rudy Wijnands, Andrew Cumming, Nils Andersson, Tomaso Belloni, M. C. Miller, Roman Wawrzaszek, Stefano Bianchi, Enrique García-Berro, Sandro Mereghetti, C. Guidorzi, C. Corral Van Damme, Søren Brandt, Francesco Tombesi, Felix Ryde, Didier Barret, Simon Vaughan, Marco Feroci, T. Di Salvo, C. van Baren, Angelo Antonelli, Marc Ribó, J. L. Atteia, P. Soleri, Alessio Trois, Silvia Zane, G. Mouret, Ersin Gogus, Emanuele Perinati, J. Coker, Piero Malcovati, V. Mangano, F. Jetter, P. Uter, P. Romano, M. Nowak, Roberto Turolla, Laura Tolos, Antonino D'Ai, Laura Alvarez, C. Amoros, Simone Scaringi, A. Possenti, David M. Smith, M. Falanga, A. Goldwurm, René Hudec, Ignacio Negueruela, M. van der Klis, Francesco Longo, José A. Pons, I. M. McHardy, R. Rohlfs, P. Cais, Luigi Stella, S. Di Cosimo, Antoine Rousseau, M. Ayre, M. Gschwender, D. Klochkov, Niels Lund, Chryssa Kouveliotou, P. Azzarello, F. Château, Michael Gabler, S. Vercellone, Martin Durant, I. Donnarumma, Giorgio Matt, Mauro Orlandini, P. Kaaret, Patrick Smith, P. T. O'Brien, A. Argan, M. Orienti, Marco Grassi, Claudio Labanti, Edward F. Brown, Christopher S. Reynolds, Gloria Sala, Y. Evangelista, Gabriel Török, José Braga, Riccardo Campana, Alan Smith, C. Gouiffes, Nevin N. Weinberg, Leonardo Gualtieri, Yannick Favre, P.G. Jonker, Gabriele Giovannini, D. de Martino, Irfan Kuvvetli, S. Motta, Teresa Mineo, Paul J. Groot, Pablo Reig, Martino Marisaldi, Andrea Sanna, Lorenzo Amati, G. L. Israel, D. Macera, K. S. Wood, Pablo Cerdá-Durán, F. Fuschino, Suvi Gezari, Mariano Mendez, Slawomir Suchy, Damien Rambaud, Nanda Rea, R. Artigue, J.-Y. Seyler, S. N. Shore, Frederick K. Lamb, Jörn Wilms, Mark G. Alford, Margarita Hernanz, Thomas M. Tauris, Luca Izzo, Tobias Boenke, J. J. M. in 't Zand, J. Mulačová, P. Binko, Daniel Maier, Jan Schee, Bruce Gendre, Enrico Bozzo, Paul S. Ray, Giuseppe Bertuccio, Simone Migliari, Ignazio Bombaci, Vladimir Karas, Nikolaos Stergioulas, P. P. Laubert, D. Karelin, A. C. Fabian, Giovanni Miniutti, Dacheng Lin, L. Guy, Martine Mouchet, Colleen A. Wilson-Hodge, Valeria Ferrari, Kai Hebeler, Mark H. Finger, Shigeto Watanabe, Pawel Haensel, H. Jacobs, Adrian Martindale, A. A. Zdziarski, Andrea Santangelo, Giuseppe Baldazzi, Piergiorgio Casella, Fabio Muleri, M. Hailey, Antonio Bianchini, Giuseppe Lodato, E. Del Monte, M. Rapisarda, Zdeněk Stuchlík, Alain Cros, V. Sochora, Laurens Keek, Jorge Casares, Andrew Melatos, Pere Blay, E. Rossi, A. P. Spencer, G. Stratta, Conrado Albertus, J. M. Paredes, M. Ahangarianabhari, Anna L. Watts, M. Del Santo, I. Kreykenbohm, Alessandro Patruno, G. A. Caliandro, C. Feldman, M. Pohl, Fabrizio Tamburini, G. Zampa, Marina Orio, Flemming Hansen, P. Ramon, Ruben Salvaterra, David H. Lumb, Edward M. Cackett, Andrew Shearer, Sharon M. Morsink, L. Pacciani, J.-M. Bonnet Bidaud, A. De Luca, Jérôme Chenevez, Sebastian Diebold, N. Zampa, Carole A. Haswell, Luciano Burderi, E. Cavazzuti, Adam Ingram, Dhiren Kataria, Berend Winter, A. Vacchi, W. Hermsen, P. Giommi, Dong Lai, N. A. Webb, P. Bodin, Dom Walton, Solen Balman, Benjamin Stappers, M. Burgay, Luca Zampieri, Carl Budtz-Jørgensen, Ralph A. M. J. Wijers, Giancarlo Cusumano, J. L. Galvez Sanchez, Raffaella Schneider, Luciano Rezzolla, Alexander Heger, S. Korpela, Dimitrios Emmanoulopoulos, Biswajit Paul, Diego Götz, B. Artigues, Paolo Soffitta, M. H. Finger, J. W. den Herder, Paolo Esposito, Kazushi Iwasawa, Poul Erik Holmdahl Olsen, J. Neilsen, Marco Barbera, Deepto Chakrabarty, R. A. Osten, M. Reina Aranda, A. J. Castro-Tirado, Andrea Tramacere, D. Haas, Johannes Dercksen, John A. Tomsick, A. V. Penacchioni, V. D'Elia, Alfonso Collura, Altan Baykal, P. Le Provost, S. Turriziani, Kostas D. Kokkotas, Duncan K. Galloway, Ron Remillard, Juhani Huovelin, Somak Bhattacharyya, Pavel Bakala, Phil Uttley, Richard E. Cole, Mahesh Prakash, L. Kuiper, T. Munoz-Darias, Diego F. Torres, S. Mahmoodifar, G. Ramsay, Andrew Norton, T. Kennedy, Achim Schwenk, L. Zdunik, A. B. Giles, Jerome Rodriguez, C. Motch, Ilya Mandel, Marcello Giroletti, Dimitrios Psaltis, J. Sandberg, Fiamma Capitanio, Remon Cornelisse, M. R. Gilfanov, Peggy Varniere, Franck Cadoux, Peter J. Wheatley, M. de Pasquale, Juri Poutanen, S. Maestre, A. Pellizzoni, Axel Schwope, Diego Altamirano, Piotr Orleanski, V. Vrba, Agata Różańska, Kateřina Goluchová, P. Rodríguez Gil, Niccolò Bucciantini, Stéphane Schanne, Carlo Ferrigno, Thomas J. Maccarone, H. Wende, Tod E. Strohmayer, Tadayuki Takahashi, Francois Lebrun, E. Kuulkers, Jeroen Homan, Maurizio Paolillo, M. A. Perez, J. P. Osborne, A. Alpar, Sanjay Reddy, G.W. Fraser, V. Sulemainov, D. Linder, L. Sabau-Graziati, A. Rachevski, Bing Zhang, Alessandro Papitto, C. Tenzer, Alex Markowitz, J. Portell, Roberto Mignani, Fabrizio Bocchino, Arnau Rios, R. de la Rie, M. Wille, A. de Rosa, Alessandro Riggio, M. Frericks, Andrew W. Steiner, Michal Bursa, Federico Bernardini, Jon M. Miller, W. Kluzniak, INAF - Osservatorio Astronomico di Roma ( OAR ), Istituto Nazionale di Astrofisica ( INAF ), Laboratoire d'Astrophysique de l'Observatoire Midi-Pyrénées ( LATT ), Université Paul Sabatier - Toulouse 3 ( UPS ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire Midi-Pyrénées ( OMP ) -Centre National de la Recherche Scientifique ( CNRS ), Variable Energy Cyclotron Centre, Institut Pasteur de Montevideo, Réseau International des Instituts Pasteur ( RIIP ) -Institut Pasteur de Montevideo, Mullard Space Science Laboratory ( MSSL ), University College of London [London] ( UCL ), FORMATION STELLAIRE 2014, Laboratoire d'astrodynamique, d'astrophysique et d'aéronomie de bordeaux ( L3AB ), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Observatoire aquitain des sciences de l'univers ( OASU ), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Laboratoire d'Astrophysique de Bordeaux [Pessac] ( LAB ), Université de Bordeaux ( UB ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Bordeaux ( UB ), Instituto de Astrofísica de Andalucía ( IAA ), Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), Institut de Recherches sur les lois Fondamentales de l'Univers ( IRFU ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Interactions et dynamique des environnements de surface ( IDES ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Licryl Laboratory ( CNR-IPCF UOS Cosenza ), University of Calabria, Laboratori Nazionali di Frascati ( LNF ), National Institute for Nuclear Physics ( INFN ), PCAS, Istituto di Astrofisica Spaziale e Fisica Cosmica - Milano ( IASF-MI ), AstroParticule et Cosmologie ( APC - UMR 7164 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Astrophysique Interactions Multi-échelles ( AIM - UMR 7158 - UMR E 9005 ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Paris Diderot - Paris 7 ( UPD7 ), Canada's National Laboratory for Particle and Nuclear Physics ( TRIUMF ), NRC, Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] ( UNIBO ), Institut de recherches sur la catalyse et l'environnement de Lyon ( IRCELYON ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Univers et Théories ( LUTH ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Spectrochimie Infrarouge et Raman - UMR 8516 ( LASIR ), Université de Lille-Centre National de la Recherche Scientifique ( CNRS ), Dipartimento di Scienze Fisiche [Naples], Università degli studi di Napoli Federico II, Energétique, propulsion, espace, environnement ( EPEE ), Université d'Orléans ( UO ) -Centre National de la Recherche Scientifique ( CNRS ), Department of Physics and Astronomy [Hanover], Dartmouth College [Hanover], Institut de recherche en astrophysique et planétologie ( IRAP ), Université Paul Sabatier - Toulouse 3 ( UPS ) -Observatoire Midi-Pyrénées ( OMP ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d’Optique Atmosphérique - UMR 8518 ( LOA ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Université de Lille-Centre National de la Recherche Scientifique ( CNRS ), Institut de Biologie du Développement de Marseille ( IBDM ), Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Universitat Politècnica de Catalunya [Barcelona] ( UPC ), INAF-IASF Milano, Climate and Environmental Physics [Bern], University of Bern, Centre National d'Etudes Spatiales ( CNES ), Institute of Geology, Eidgenössische Technische Hochschule [Zürich] ( ETH Zürich ), IEEC-CSIC, Universitat Autònoma de Barcelona [Barcelona] ( UAB ), MedisysResearch Lab ( Medisys ), Philips Research, European Space Astronomy Center ( ESAC ), European Space Agency ( ESA ), High Energy Astrophys. & Astropart. Phys (API, FNWI), INAF - Osservatorio Astronomico di Roma (OAR), Istituto Nazionale di Astrofisica (INAF), Laboratoire d'Astrophysique de l'Observatoire Midi-Pyrénées (LATT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Réseau International des Instituts Pasteur (RIIP), Mullard Space Science Laboratory (MSSL), University College of London [London] (UCL), Laboratoire d'astrodynamique, d'astrophysique et d'aéronomie de bordeaux (L3AB), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Interactions et dynamique des environnements de surface (IDES), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Licryl Laboratory (CNR-IPCF UOS Cosenza), Università della Calabria [Arcavacata di Rende] (Unical), Laboratori Nazionali di Frascati (LNF), Istituto Nazionale di Fisica Nucleare (INFN), Istituto di Astrofisica Spaziale e Fisica Cosmica - Milano (IASF-MI), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Canada's particle accelerator centre (TRIUMF), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 (LASIRE), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), University of Naples Federico II = Università degli studi di Napoli Federico II, Energétique, propulsion, espace, environnement (EPEE), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Laboratoire d’Optique Atmosphérique - UMR 8518 (LOA), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Universitat Politècnica de Catalunya [Barcelona] (UPC), Climate and Environmental Physics [Bern] (CEP), Physikalisches Institut [Bern], Universität Bern [Bern] (UNIBE)-Universität Bern [Bern] (UNIBE), Centre National d'Études Spatiales [Toulouse] (CNES), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Universitat Autònoma de Barcelona (UAB), MedisysResearch Lab (Medisys), European Space Astronomy Centre (ESAC), Agence Spatiale Européenne = European Space Agency (ESA), SPIE, Takahashi, Tadayuki, Feroci M., Den Herder J.W., Bozzo E., Barret D., Brandt S., Hernanz M., Van Der Klis M., Pohl M., Santangelo A., Stella L., Watts A., Wilms J., Zane S., Ahangarianabhari M., Albertus C., Alford M., Alpar A., Altamirano D., Alvarez L., Amati L., Amoros C., Andersson N., Antonelli A., Argan A., Artigue R., Artigues B., Atteia J.-L., Azzarello P., Bakala P., Baldazzi G., Balman S., Barbera M., Van Baren C., Bhattacharyya S., Baykal A., Belloni T., Bernardini F., Bertuccio G., Bianchi S., Bianchini A., Binko P., Blay P., Bocchino F., Bodin P., Bombaci I., Bonnet Bidaud J.-M., Boutloukos S., Bradley L., Braga J., Brown E., Bucciantini N., Burderi L., Burgay M., Bursa M., Budtz-Jorgensen C., Cackett E., Cadoux F.R., Cais P., Caliandro G.A., Campana R., Campana S., Capitanio F., Casares J., Casella P., Castro-Tirado A.J., Cavazzuti E., Cerda-Duran P., Chakrabarty D., Chateau F., Chenevez J., Coker J., Cole R., Collura A., Cornelisse R., Courvoisier T., Cros A., Cumming A., Cusumano G., D'ai A., D'elia V., Del Monte E., De Luca A., De Martino D., Dercksen J.P.C., De Pasquale M., De Rosa A., Del Santo M., Di Cosimo S., Diebold S., Di Salvo T., Donnarumma I., Drago A., Durant M., Emmanoulopoulos D., Erkut M.H., Esposito P., Evangelista Y., Fabian A., Falanga M., Favre Y., Feldman C., Ferrari V., Ferrigno C., Finger M., Finger M.H., Fraser G.W., Frericks M., Fuschino F., Gabler M., Galloway D.K., Galvez Sanchez J.L., Garcia-Berro E., Gendre B., Gezari S., Giles A.B., Gilfanov M., Giommi P., Giovannini G., Giroletti M., Gogus E., Goldwurm A., Goluchova K., Gotz D., Gouiffes C., Grassi M., Groot P., Gschwender M., Gualtieri L., Guidorzi C., Guy L., Haas D., Haensel P., Hailey M., Hansen F., Hartmann D.H., Haswell C.A., Hebeler K., Heger A., Hermsen W., Homan J., Hornstrup A., Hudec R., Huovelin J., Ingram A., In't Zand J.J.M., Israel G., Iwasawa K., Izzo L., Jacobs H.M., Jetter F., Johannsen T., Jonker P., Jose J., Kaaret P., Kanbach G., Karas V., Karelin D., Kataria D., Keek L., Kennedy T., Klochkov D., Kluzniak W., Kokkotas K., Korpela S., Kouveliotou C., Kreykenbohm I., Kuiper L.M., Kuvvetli I., Labanti C., Lai D., Lamb F.K., Laubert P.P., Lebrun F., Lin D., Linder D., Lodato G., Longo F., Lund N., Maccarone T.J., Macera D., Maestre S., Mahmoodifar S., Maier D., Malcovati P., Mandel I., Mangano V., Manousakis A., Marisaldi M., Markowitz A., Martindale A., Matt G., Mchardy I.M., Melatos A., Mendez M., Mereghetti S., Michalska M., Migliari S., Mignani R., Miller M.C., Miller J.M., Mineo T., Miniutti G., Morsink S., Motch C., Motta S., Mouchet M., Mouret G., Mulaova J., Muleri F., Munoz-Darias T., Negueruela I., Neilsen J., Norton A.J., Nowak M., O'brien P., Olsen P.E.H., Orienti M., Orio M., Orlandini M., Orleaaski P., Osborne J.P., Osten R., Ozel F., Pacciani L., Paolillo M., Papitto A., Paredes J.M., Patruno A., Paul B., Perinati E., Pellizzoni A., Penacchioni A.V., Perez M.A., Petracek V., Pittori C., Pons J., Portell J., Possenti A., Poutanen J., Prakash M., Le Provost P., Psaltis D., Rambaud D., Ramon P., Ramsay G., Rapisarda M., Rachevski A., Rashevskaya I., Ray P.S., Rea N., Reddy S., Reig P., Reina Aranda M., Remillard R., Reynolds C., Rezzolla L., Ribo M., De La Rie R., Riggio A., Rios A., Rodriguez-Gil P., Rodriguez J., Rohlfs R., Romano P., Rossi E.M.R., Rozanska A., Rousseau A., Ryde F., Sabau-Graziati L., Sala G., Salvaterra R., Sanna A., Sandberg J., Scaringi S., Schanne S., Schee J., Schmid C., Shore S., Schneider R., Schwenk A., Schwope A.D., Seyler J.-Y., Shearer A., Smith A., Smith D.M., Smith P.J., Sochora V., Soffitta P., Soleri P., Spencer A., Stappers B., Steiner A.W., Stergioulas N., Stratta G., Strohmayer T.E., Stuchlik Z., Suchy S., Sulemainov V., Takahashi T., Tamburini F., Tauris T., Tenzer C., Tolos L., Tombesi F., Tomsick J., Torok G., Torrejon J.M., Torres D.F., Tramacere A., Trois A., Turolla R., Turriziani S., Uter P., Uttley P., Vacchi A., Varniere P., Vaughan S., Vercellone S., Vrba V., Walton D., Watanabe S., Wawrzaszek R., Webb N., Weinberg N., Wende H., Wheatley P., Wijers R., Wijnands R., Wille M., Wilson-Hodge C.A., Winter B., Wood K., Zampa G., Zampa N., Zampieri L., Zdunik L., Zdziarski A., Zhang B., Zwart F., Ayre M., Boenke T., Corral Van Damme C., Kuulkers E., Lumb D., Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille Institut (CLIL), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Universität Bern [Bern]-Universität Bern [Bern], European Space Agency (ESA), Feroci, M., den Herder, J., Bozzo, E., Barret, D., Brandt, S., Hernanz, M., van der Klis, M., Pohl, M., Santangelo, A., Stella, L., Watts, A., Wilms, J., Zane, S., Ahangarianabhari, M., Albertus, C., Alford, M., Alpar, A., Altamirano, D., Alvarez, L., Amati, L., Amoros, C., Andersson, N., Antonelli, A., Argan, A., Artigue, R., Artigues, B., Atteia, J., Azzarello, P., Bakala, P., Baldazzi, G., Balman, S., Barbera, M., van Baren, C., Bhattacharyya, S., Baykal, A., Belloni, T., Bernardini, F., Bertuccio, G., Bianchi, S., Bianchini, A., Binko, P., Blay, P., Bocchino, F., Bodin, P., Bombaci, I., Bonnet Bidaud, J., Boutloukos, S., Bradley, L., Braga, J., Brown, E., Bucciantini, N., Burderi, L., Burgay, M., Bursa, M., Budtz Jørgensen, C., Cackett, E., Cadoux, F., Caïs, P., Caliandro, G., Campana, R., Campana, S., Capitanio, F., Casares, J., Casella, P., Castro Tirado, A., Cavazzuti, E., Cerda Duran, P., Chakrabarty, D., Château, F., Chenevez, J., Coker, J., Cole, R., Collura, A., Cornelisse, R., Courvoisier, T., Cros, A., Cumming, A., Cusumano, G., D'Ai', A., D'Elia, V., Del Monte, E., de Luca, A., de Martino, D., Dercksen, J., de Pasquale, M., De Rosa, A., Del Santo, M., Di Cosimo, S., Diebold, S., DI SALVO, T., Donnarumma, I., Drago, A., Durant, M., Emmanoulopoulos, D., Erkut, M., Esposito, P., Evangelista, Y., Fabian, A., Falanga, M., Favre, Y., Feldman, C., Ferrari, V., Ferrigno, C., Finger, M., Fraser, G., Frericks, M., Fuschino, F., Gabler, M., Galloway, D., Galvez Sanchez, J., Garcia Berro, E., Gendre, B., Gezari, S., Giles, A., Gilfanov, M., Giommi, P., Giovannini, G., Giroletti, M., Gogus, E., Goldwurm, A., Goluchová, K., Götz, D., Gouiffes, C., Grassi, M., Groot, P., Gschwender, M., Gualtieri, L., Guidorzi, C., Guy, L., Haas, D., Haensel, P., Hailey, M., Hansen, F., Hartmann, D., Haswell, C., Hebeler, K., Heger, A., Hermsen, W., Homan, J., Hornstrup, A., Hudec, R., Huovelin, J., Ingram, A., In't Zand, J., Israel, G., Iwasawa, K., Izzo, L., Jacobs, H., Jetter, F., Johannsen, T., Jonker, P., Josè, J., Kaaret, P., Kanbach, G., Karas, V., Karelin, D., Kataria, D., Keek, L., Kennedy, T., Klochkov, D., Kluzniak, W., Kokkotas, K., Korpela, S., Kouveliotou, C., Kreykenbohm, I., Kuiper, L., Kuvvetli, I., Labanti, C., Lai, D., Lamb, F., Laubert, P., Lebrun, F., Lin, D., Linder, D., Lodato, G., Longo, F., Lund, N., Maccarone, T., Macera, D., Maestre, S., Mahmoodifar, S., Maier, D., Malcovati, P., Mandel, I., Mangano, V., Manousakis, A., Marisaldi, M., Markowitz, A., Martindale, A., Matt, G., Mchardy, I., Melatos, A., Mendez, M., Mereghetti, S., Michalska, M., Migliari, S., Mignani, R., Miller, M., Miller, J., Mineo, T., Miniutti, G., Morsink, S., Motch, C., Motta, S., Mouchet, M., Mouret, G., Mulačová, J., Muleri, F., Muñoz Darias, T., Negueruela, I., Neilsen, J., Norton, A., Nowak, M., O'Brien, P., Olsen, P., Orienti, M., Orio, M., Orlandini, M., Orleański, P., Osborne, J., Osten, R., Ozel, F., Pacciani, L., Paolillo, M., Papitto, A., Paredes, J., Patruno, A., Paul, B., Perinati, E., Pellizzoni, A., Penacchioni, A., Perez, M., Petracek, V., Pittori, C., Pons, J., Portell, J., Possenti, A., Poutanen, J., Prakash, M., Le Provost, P., Psaltis, D., Rambaud, D., Ramon, P., Ramsay, G., Rapisarda, M., Rachevski, A., Rashevskaya, I., Ray, P., Rea, N., Reddy, S., Reig, P., Reina Aranda, M., Remillard, R., Reynolds, C., Rezzolla, L., Ribo, M., de la Rie, R., Riggio, A., Rios, A., Rodríguez Gil, P., Rodriguez, J., Rohlfs, R., Romano, P., Rossi, E., Rozanska, A., Rousseau, A., Ryde, F., Sabau Graziati, L., Sala, G., Salvaterra, R., Sanna, A., Sandberg, J., Scaringi, S., Schanne, S., Schee, J., Schmid, C., Shore, S., Schneider, R., Schwenk, A., Schwope, A., Seyler, J., Shearer, A., Smith, A., Smith, D., Smith, P., Sochora, V., Soffitta, P., Soleri, P., Spencer, A., Stappers, B., Steiner, A., Stergioulas, N., Stratta, G., Strohmayer, T., Stuchlik, Z., Suchy, S., Sulemainov, V., Takahashi, T., Tamburini, F., Tauris, T., Tenzer, C., Tolos, L., Tombesi, F., Tomsick, J., Torok, G., Torrejon, J., Torres, D., Tramacere, A., Trois, A., Turolla, R., Turriziani, S., Uter, P., Uttley, P., Vacchi, A., Varniere, P., Vaughan, S., Vercellone, S., Vrba, V., Walton, D., Watanabe, S., Wawrzaszek, R., Webb, N., Weinberg, N., Wende, H., Wheatley, P., Wijers, R., Wijnands, R., Wille, M., Wilson Hodge, C., Winter, B., Wood, K., Zampa, G., Zampa, N., Zampieri, L., Zdunik, L., Zdziarski, A., Zhang, B., Zwart, F., Ayre, M., Boenke, T., Corral van Damme, C., Kuulkers, E., Lumb, D., Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Consejo Superior de Investigaciones Científicas [Spain] (CSIC), National Institute for Nuclear Physics (INFN), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Canada's National Laboratory for Particle and Nuclear Physics (TRIUMF), Università di Bologna [Bologna] (UNIBO), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Spectrochimie Infrarouge et Raman - UMR 8516 (LASIR), Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Aix Marseille Université (AMU)-Collège de France (CdF)-Centre National de la Recherche Scientifique (CNRS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), Universitat Autònoma de Barcelona [Barcelona] (UAB), Astronomy, den Herder, J. W., Atteia, J. L., Bonnet Bidaud, J. M., Cadoux, F. R., Cais, P., Caliandro, G. A., Castro Tirado, A. J., D'Aì, A., De Luca, A., De Martino, D., Dercksen, J. P. C., De Pasquale, M., Di Salvo, T., Erkut, M. H., Finger, M. H., Fraser, G. W., Galloway, D. K., Galvez Sanchez, J. L., Giles, A. B., Hartmann, D. H., Haswell, C. A., in't Zand, J. J. M., Jacobs, H. M., Kuiper, L. M., Lamb, F. K., Laubert, P. P., Maccarone, T. J., Mchardy, I. M., Miller, M. C., Miller, J. M., Norton, A. J., Olsen, P. E. H., Orleanski, P., Osborne, J. P., Paolillo, Maurizio, Paredes, J. M., Penacchioni, A. V., Perez, M. A., Ray, P. S., Rossi, E. M. R., Schwope, A. D., Seyler, J. Y., Smith, D. M., Smith, P. J., Steiner, A. W., Strohmayer, T. E., Torrejon, J. M., Torres, D. F., and Wilson Hodge, C. A.

Subjects
x-ray and γ-ray instrumentation, compact objects, microchannel plates, X-ray detectors, X-ray imaging, X-ray spectroscopy, X-ray timing, Electronic, Optical and Magnetic Materials, Condensed Matter Physics, Computer Science Applications1707 Computer Vision and Pattern Recognition, Applied Mathematics, Electrical and Electronic Engineering, Vision, Observatories, Field of view, 01 natural sciences, 7. Clean energy, neutron stars, Observatory, 010303 astronomy & astrophysics, Physics, Equipment and services, Astrophysics::Instrumentation and Methods for Astrophysics, Steradian, [ SDU.ASTR.IM ] Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Astrophysics - Instrumentation and Methods for Astrophysics, X-ray detector, [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Cosmic Vision, Spectral resolution, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, NO, microchannel plate, Settore FIS/05 - Astronomia e Astrofisica, X-rays, compact object, 0103 physical sciences, Electronic, Optical and Magnetic Materials, Instrumentation and Methods for Astrophysics (astro-ph.IM), dense hadronic matter, Sensors, 010308 nuclear & particles physics, Astronomy, Accretion (astrophysics), [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Neutron star, 13. Climate action, [ PHYS.ASTR.IM ] Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Gamma-ray burst, astro-ph.IM
Abstract

The Large Observatory For x-ray Timing (LOFT) was studied within ESA M3 Cosmic Vision framework and participated in the final down-selection for a launch slot in 2022-2024. Thanks to the unprecedented combination of effective area and spectral resolution of its main instrument, LOFT will study the behaviour of matter under extreme conditions, such as the strong gravitational field in the innermost regions of accretion flows close to black holes and neutron stars, and the supra-nuclear densities in the interior of neutron stars. The science payload is based on a Large Area Detector (LAD, 10 m 2 effective area, 2-30 keV, 240 eV spectral resolution, 1 deg collimated field of view) and a WideField Monitor (WFM, 2-50 keV, 4 steradian field of view, 1 arcmin source location accuracy, 300 eV spectral resolution). The WFM is equipped with an on-board system for bright events (e.g. GRB) localization. The trigger time and position of these events are broadcast to the ground within 30 s from discovery. In this paper we present the status of the mission at the end of its Phase A study., Proc. SPIE 9144, Space Telescopes and Instrumentation 2014: Ultraviolet to Gamma Ray, 91442T

Published
2014

40. An Inservice Education Model: Teachers and Professors as Coequals.

Author

Binko, James B. and Neubert, Gloria A.

Abstract

The National Writing Project is a collaborative effort between teachers and professors aimed at the improvement of teaching. A discussion of the project's history and structure and implications for other cooperative efforts in inservice education are offered. (DF)

Published
1984

41. Vitamin D improves sunburns by increasing autophagy in M2 macrophages

Author

Das, Lopa M., Binko, Amy M., Traylor, Zachary P., Peng, Han, and Lu, Kurt Q.

Abstract

ABSTRACTCutaneous inflammation from UV radiation exposure causes epidermal damage, cellular infiltration, and secretion of pro-inflammatory mediators that exacerbate tissue destruction. Recovery is mediated chiefly by anti-inflammatory M2 macrophages that suppress inflammation and augment epidermal regeneration. Vitamin D enables anti-inflammation to promote tissue repair in response to injury. Since vitamin D enhances cellular macroautophagy/autophagy, we investigated the role of autophagy in vitamin D protection of UV-mediated sunburn and inflammation. Using a UV-mediated acute skin injury mouse model, we demonstrate that a single dose of vitamin D resolves injury with sustained inhibition of inflammatory cytokines associated with enhanced autophagy in myeloid anti-inflammatory M2 macs. Increased MAP1LC3B/LC3 expression corroborated with complete autolysosome formation detected by electron microscopy and correlated with degradation of SQSTM1/p62 in the skin following vitamin D treatment. Specifically, pharmacological inhibition of autophagy increased UV-induced apoptosis, suppressed M2 macs recruitment, and prevented vitamin D downregulation of Tnfand Mmp9in the skin. Furthermore, selective deletion of autophagy in myeloid cells of atg7cKO mice abrogated vitamin D-mediated protection and recapitulated UV-induced inflammation. Mechanistically, vitamin D signaling activated M2-autophagy regulators Klf4, Pparg, and Arg1. Lastly, analysis of UV-exposed human skin biopsies detected a similar increase in macrophage autophagy following vitamin D intervention, identifying an essential role for autophagy in vitamin D-mediated protection of skin from UV damage.Abbreviations: ARG1: arginase 1; ATG7 cKO: autophagy related 7 conditional knockout; HPF: high powered field; KLF4: Kruppel like factor 4; MAP1LC3B/LC3: microtubule-associated protein 1 light chain 3 beta; macs: macrophage; 3-MA: 3-methyladenine; MMP9: matrix metallopeptidase 9; NOS2: nitric oxide synthase 2, inducible; PPARG: peroxisome proliferator activated receptor gamma; SQSTM1/p62: sequestosome 1; TNF: tumor necrosis factor; UV: ultraviolet; VD: vitamin D, 25-hydroxy vitamin D3; 1,25-VD: 1, 25-dihydroxy vitamin D3

Published
2019
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42. INTEGRAL in HEAVENS

Author

V. G. Savchenko, P. Binko, R. Rohlfs, M. Meharga, Mathias Beck, Roland Walter, Pol Bordas, Lucia Pavan, N. Morisset, A. Frankowski, Carlo Ferrigno, and Nicolas Produit

Published
2011

45. Right atrial and ventricular function evaluated with speckle tracking in patients with acute pulmonary embolism.

Author

Ramberg, Emilie, Olausson, Maria, SalkvistJørgensen, Tem Bendix, Lindholmer Nepper, Malene, Bhardwaj, Priya, Binko, Tomas Sorm, Petersen, Jan Roland, Fornitz, Gitte Gleerup, Jørgensen, Tem Bendix Salkvist, and Nepper, Malene Lindholmer

Abstract

Aims: Assessment of right ventricular (RV) function in acute pulmonary embolism (PE) has prognostic significance. The aim of this study was to evaluate right atrium (RA) and RV myocardial damage with 2-dimensional speckle-tracking in patients with an acute central vs an acute peripheral PE.Methods and Results: Twenty-six patients with acute PE and 10 controls were retrospectively enrolled. Right atrium and RV myocardial deformation was analyzed using speckle-tracking imaging echocardiography. Parameters were evaluated to illustrate myocardial damage in patients with a central or a peripherally located PE. Thirteen of the enrolled patients had a massive central PE, and thirteen subjects had a peripheral located PE. Baseline characteristics were not significantly different between the 3 groups besides a more elevated heart rate among patients with a central PE (P = .02) and a tendency of an increased D-dimer in this group. Right ventricular dimensions were more affected among patients with a PE. Compared with controls, segmental RV and RA strain/strain rate in the free wall was significantly reduced in patients with PE (P < .05). No difference was shown between the 2 groups of PE.Conclusion: This pilot study suggests that basal-/mid-segments of RA and RV free wall are more affected in patients with a PE compared with controls. Interestingly, we found no significant difference in myocardial RA and RV damage between patients with a central and a peripheral PE. We advocate that PE no matter central or peripheral is a serious condition and that a peripheral PE has to be intensively treated similar to a central PE. [ABSTRACT FROM AUTHOR]

Published
2017
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46. COVID-associated acute limb ischemia during the Delta surge and the effect of vaccines.

Author

Xie, Bowen, Semaan, Dana B., Binko, Mary A., Agrawal, Nishant, Kulkarni, Rohan N., Andraska, Elizabeth A., Sachdev, Ulka, Chaer, Rabih A., Eslami, Mohammad H., Makaroun, Michel S., and Sridharan, Natalie

Abstract

Hypercoagulability is common in severe acute respiratory syndrome coronavirus 2 and has been associated with arterial thrombosis leading to acute limb ischemia (ALI). Our objective was to determine the outcomes of concurrent coronavirus disease 2019 (COVID-19) infection and ALI, particularly during the Delta variant surge and the impact of vaccination status. A retrospective review was performed of patients treated at a single health care system between March 2020 and December 2021 for ALI and recent (<14 days) COVID-19 infection or who developed ALI during hospitalization for the same disease. Patients were grouped by year as well as by pre and post Delta variant emergence in 2021 based on the World Health Organization timeline (January to May vs June to December). Baseline demographics, imaging, interventions, and outcomes were evaluated. A control cohort of all patients with ALI requiring surgical intervention for a 2-year period prior to the pandemic was used for comparison. Primary outcomes were in-hospital mortality and amputation-free survival. Kaplan-Meier survival and Cox proportional hazards analysis were performed. Forty acutely ischemic limbs were identified in 36 patients with COVID-19, the majority during the Delta surge (52.8%) and after the wide availability of vaccines. The rate of COVID-19-associated ALI, although low overall, nearly doubled during the Delta surge (0.37% vs 0.20%; P =.09). Intervention (open or endovascular revascularization vs primary amputation) was performed on 31 limbs in 28 individuals, with the remaining eight treated with systemic anti-coagulation. Postoperative mortality was 48%, and overall mortality was 50%. Major amputation following revascularization was significantly higher with COVID-19 ALI (25% vs 3%; P =.006) compared with the pre-pandemic group. Thirty-day amputation-free survival was significantly lower (log-rank P <.001). COVID-19 infection (adjusted hazard ratio, 6.2; P <.001) and age (hazard ratio, 1.1; P =.006) were associated with 30-day amputation in multivariate analysis. Severity of COVID-19 infection, defined as vasopressor usage, was not associated with post-revascularization amputation. There was a higher incidence of re-thrombosis in the latter half of 2021 with the Delta surge, as reintervention for recurrent ischemia of the same limb was more common than our previous experience (21% vs 0%; P =.55). COVID-19-associated limb ischemia occurred almost exclusively in non-vaccinated patients (92%). ALI observed with Delta appears more resistant to standard therapy. Unvaccinated status correlated highly with ALI occurrence in the setting of COVID-19 infection. Information of limb loss as a COVID-19 complication among non-vaccinated patients may help to increase compliance. [ABSTRACT FROM AUTHOR]

Published
2023
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47. The H1 detector at HERA

Author

I. Abt, T. Ahmed, S. Aid, V. Andreev, B. Andrieu, R.D. Appuhn, C. Arnault, M. Arpagaus, A. Babaev, H. Bärwolff, J. Bán, E. Banas, P. Baranov, E. Barrelet, W. Bartel, M. Barth, U. Bassler, F. Basti, D.E. Baynham, J.-M. Baze, G.A. Beck, H.P. Beck, D. Bederede, H.-J. Behrend, C. Beigbeder, A. Belousov, Ch. Berger, H. Bergstein, R. Bernard, G. Bernardi, R. Bernet, R. Bernier, U. Berthon, G. Bertrand-Coremans, M. Besançon, R. Beyer, J.-C. Biasci, P. Biddulph, V. Bidoli, E. Binder, P. Binko, J.-C. Bizot, V. Blobel, F. Blouzon, H. Blume, K. Borras, V. Boudry, C. Bourdarios, F. Brasse, W. Braunschweig, D. Breton, H. Brettel, V. Brisson, D. Bruncko, C. Brune, U. Buchner, L. Büngener, J. Bürger, F.W. Büsser, A. Buniatian, S. Burke, P. Burmeister, A. Busata, G. Buschhorn, A.J. Campbell, T. Carli, F. Charles, M. Charlet, R. Chase, D. Clarke, A.B. Clegg, M. Colombo, V. Commichau, J.F. Connolly, U. Cornett, J.A. Coughlan, A. Courau, M.-C. Cousinou, Ch. Coutures, A. Coville, G. Cozzika, D.A. Cragg, L. Criegee, H.I. Cronström, N.H. Cunliffe, J. Cvach, A. Cyz, S. Dagoret, J.B. Dainton, M. Danilov, A.W.E. Dann, D. Darvill, W.D. Dau, J. David, M. David, R.J. Day, E. Deffur, B. Delcourt, L. Del Buono, F. Descamps, M. Devel, J.P. Dewulf, A. De Roeck, P. Dingus, K. Djidi, C. Dollfus, J.D. Dowell, H.B. Dreis, A. Drescher, U. Dretzler, J. Duboc, A. Ducorps, D. Düllmann, O. Dünger, H. Duhm, B. Dulny, F. Dupont, R. Ebbinghaus, M. Eberle, J. Ebert, T.R. Ebert, G. Eckerlin, B.W.H. Edwards, V. Efremenko, S. Egli, S. Eichenberger, R. Eichler, F. Eisele, E. Eisenhandler, N.N. Ellis, R.J. Ellison, E. Elsen, A. Epifantsev, M. Erdmann, W. Erdmann, G. Ernst, E. Evrard, G. Falley, L. Favart, A. Fedotov, D. Feeken, R. Felst, J. Feltesse, Z.Y. Feng, I.F. Fensome, J. Fent, J. Ferencei, F. Ferrarotto, K. Finke, K. Flamm, W. Flauger, M. Fleischer, M. Flieser, P.S. Flower, G. Flügge, A. Fomenko, B. Fominykh, M. Forbush, J. Formánek, J.M. Foster, G. Franke, E. Fretwurst, W. Fröchtenicht, P. Fuhrmann, E. Gabathuler, K. Gabathuler, K. Gadow, K. Gamerdinger, J. Garvey, J. Gayler, E. Gažo, A. Gellrich, M. Gennis, U. Gensch, H. Genzel, R. Gerhards, K. Geske, I. Giesgen, D. Gillespie, W. Glasgow, L. Godfrey, J. Godlewski, U. Goerlach, L. Goerlich, N. Gogitidze, M. Goldberg, A.M. Goodall, I. Gorelov, P. Goritchev, L. Gosset, C. Grab, H. Grässler, R. Grässler, T. Greenshaw, C. Gregory, H. Greif, M. Grewe, G. Grindhammer, A. Gruber, C. Gruber, S. Günther, J. Haack, M. Haguenauer, D. Haidt, L. Hajduk, D. Hammer, O. Hamon, M. Hampel, D. Handschuh, K. Hangarter, E.M. Hanlon, M. Hapke, U. Harder, J. Harjes, P. Hartz, P.E. Hatton, R. Haydar, W.J. Haynes, J. Heatherington, V. Hedberg, C.R. Hedgecock, G. Heinzelmann, R.C.W. Henderson, H. Henschel, R. Herma, I. Herynek, W. Hildesheim, P. Hill, D.L. Hill, C.D. Hilton, J. Hladký, K.C. Hoeger, R.B. Hopes, R. Horisberger, A. Hrisoho, J. Huber, Ph. Huet, H. Hufnagel, N. Huot, J.-F. Huppert, M. Ibbotson, D. Imbault, H. Itterbeck, M.-A. Jabiol, A. Jacholkowska, C. Jacobsson, M. Jaffré, T. Jansen, P. Jean, J. Jeanjean, L. Jönsson, K. Johannsen, D.P. Johnson, L. Johnson, P. Jovanovic, H. Jung, P.I.P. Kalmus, D. Kant, G. Kantel, S. Karstensen, S. Kasarian, R. Kaschowitz, P. Kasselmann, U. Kathage, H.H. Kaufmann, G. Kemmerling, I.R. Kenyon, S. Kermiche, C. Keuker, C. Kiesling, M. Klein, C. Kleinwort, G. Knies, W. Ko, T. Kobler, J. Koch, T. Köhler, J. Köhne, M. Kolander, H. Kolanoski, F. Kole, J. Koll, S.D. Kolya, B. Koppitz, V. Korbel, M. Korn, P. Kostka, S.K. Kotelnikov, M.W. Krasny, H. Krehbiel, F. Krivan, D. Krücker, U. Krüger, U. Krüner-Marquis, M. Kubantsev, J.P. Kubenka, T. Külper, H.-J. Küsel, H. Küster, M. Kuhlen, T. Kurča, J. Kurzhöfer, B. Kuznik, B. Laforge, F. Lamarche, R. Lander, M.P.J. Landon, W. Lange, R. Langkau, P. Lanius, J.-F. Laporte, L. Laptin, H. Laskus, A. Lebedev, M. Lemler, U. Lenhardt, A. Leuschner, C. Leverenz, S. Levonian, D. Lewin, Ch. Ley, A. Lindner, G. Lindström, F. Linsel, J. Lipinski, B. Liss, P. Loch, A.B. Lodge, H. Lohmander, G.C. Lopez, J.-P. Lottin, V. Lubimov, K. Ludwig, D. Lüers, N. Lugetski, B. Lundberg, K. Maeshima, N. Magnussen, E. Malinovski, S. Mani, P. Marage, J. Marks, R. Marshall, J. Martens, F. Martin, G. Martin, R. Martin, H.-U. Martyn, J. Martyniak, V. Masbender, S. Masson, A. Mavroidis, S.J. Maxfield, S.J. McMahon, A. Mehta, K. Meier, J. Meissner, D. Mercer, T. Merz, C.A. Meyer, H. Meyer, J. Meyer, S. Mikocki, J.L. Mills, V. Milone, J. Möck, E. Monnier, B. Montés, F. Moreau, J. Moreels, B. Morgan, J.V. Morris, J.M. Morton, K. Müller, P. Murín, S.A. Murray, V. Nagovizin, B. Naroska, Th. Naumann, P. Nayman, A. Nepeipivo, P. Newman, D. Newman-Coburn, D. Newton, D. Neyret, H.K. Nguyen, F. Niebergall, C. Niebuhr, R. Nisius, T. Novák, H. Nováková, G. Nowak, G.W. Noyes, M. Nyberg, H. Oberlack, U. Obrock, J.E. Olsson, J. Olszowska, S. Orenstein, F. Ould-Saada, P. Pailler, S. Palanque, E. Panaro, A. Panitch, J.-Y. Parey, C. Pascaud, G.D. Patel, A. Patoux, C. Paulot, U. Pein, E. Peppel, E. Perez, P. Perrodo, A. Perus, S. Peters, J.-P. Pharabod, H.T. Phillips, J.P. Phillips, Ch. Pichler, A. Pieuchot, W. Pimpl, D. Pitzl, A. Porrovecchio, S. Prell, R. Prosi, H. Quehl, G. Rädel, F. Raupach, K. Rauschnabel, A. Reboux, P. Reimer, G. Reinmuth, S. Reinshagen, P. Ribarics, V. Riech, J. Riedlberger, H. Riege, S. Riess, M. Rietz, S.M. Robertson, P. Robmann, P. Röpnack, R. Roosen, K. Rosenbauer, A. Rostovtsev, C. Royon, A. Rudge, K. Rüter, M. Rudowicz, M. Ruffer, S. Rusakov, V. Rusinov, K. Rybicki, J. Sacton, N. Sahlmann, E. Sanchez, D.P.C. Sankey, M. Savitski, P. Schacht, S. Schiek, N. Schirm, S. Schleif, P. Schleper, W. von Schlippe, C. Schmidt, D. Schmidt, G. Schmidt, W. Schmitz, H. Schmücker, V. Schröder, J. Schütt, E. Schuhmann, M. Schulz, A. Schwind, W. Scobel, U. Seehausen, F. Sefkow, R. Sell, M. Seman, A. Semenov, P. Shatalov, V. Shekelyan, I. Sheviakov, H. Shooshtari, L.N. Shtarkov, G. Siegmon, U. Siewert, Y. Sirois, A. Sirous, I.O. Skillicorn, P. Škvařil, P. Smirnov, J.R. Smith, L. Smolik, D. Sole, Y. Soloviev, J. Špalek, H. Spitzer, R. von Staa, J. Staeck, P. Staroba, J. Šťastný, M. Steenbock, P. Štefan, P. Steffen, R. Steinberg, H. Steiner, B. Stella, K. Stephens, J. Stier, J. Stiewe, U. Stösslein, J. Strachota, U. Straumann, A. Strowbridge, W. Struczinski, J.P. Sutton, Z. Szkutnik, G. Tappern, S. Tapprogge, R.E. Taylor, V. Tchernyshov, V. Tchudakov, C. Thiebaux, K. Thiele, G. Thompson, R.J. Thompson, I. Tichomirov, C. Trenkel, W. Tribanek, K. Tröger, P. Truöl, M. Turiot, J. Turnau, J. Tutas, L. Urban, M. Urban, A. Usik, Š. Valkár, A. Valkárová, C. Vallée, G. Van Beek, M. Vanderkelen, L. Van Lancker, P. Van Mechelen, A. Vartapetian, Y. Vazdik, M. Vecko, P. Verrecchia, R. Vick, G. Villet, E. Vogel, K. Wacker, M. Wagener, I.W. Walker, A. Walther, G. Weber, D. Wegener, A. Wegner, P. Weissbach, H.P. Wellisch, L. West, D. White, S. Willard, M. Winde, G.-G. Winter, Th. Wolff, L.A. Womersley, A.E. Wright, E. Wünsch, N. Wulff, B.E. Wyborn, T.P. Yiou, J. Žáček, D. Zarbock, P. Závada, C. Zeitnitz, Z. Zhang, H. Ziaeepour, M. Zimmer, W. Zimmermann, F. Zomer, K. Zuber, Laboratoire de Physique Nucléaire et de Hautes Énergies ( LPNHE ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de l'Accélérateur Linéaire ( LAL ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Physique des Particules de Marseille ( CPPM ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Aix Marseille Université ( AMU ), H1, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Luminosity (scattering theory), Calorimeter (particle physics), Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, Detector, HERA, 01 natural sciences, law.invention, Nuclear physics, Upgrade, Data acquisition, law, [ PHYS.HEXP ] Physics [physics]/High Energy Physics - Experiment [hep-ex], 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics::Experiment, 010306 general physics, Collider, Instrumentation, Storage ring
Abstract

General aspects of the H1 detector at the electron-proton storage ring HERA as well as technical descriptions of the magnet, luminosity system, trigger, slow-control, data acquisition and off-line data handling are given. The three major components of the detector, the tracking, calorimeter and muon detectors, will be described in a forthcoming article. The present paper describes the detector that was used from 1992 to the end of 1994. After this a major upgrade of some components was undertaken. Some performance figures from luminosity runs at HERA during 1993 and 1994 are given.

Published
1997

48. The tracking calorimeter and muon detectors of the H1 experiment at Hera

Author

L. N. Shtarkov, A. Panitch, G. Tappern, R. Nisius, Armen Vartapetian, P. S. Flower, R. Bernet, D. White, K. C. Hoeger, B. Morgan, H. Bergstein, S. D. Kolya, Th. Naumann, U. Bassler, J. Žáček, A. B. Lodge, P. Jovanovic, F. Linsel, J. P Dewulf, H. Novakova, K. Gabathuler, A. Buniatian, D. Wegener, W.J. Haynes, J. R. Smith, R. Herma, S. Schiek, H. Duhm, V. Milone, E. Gažo, J. Mock, Tim Greenshaw, A. Sirous, N.H. Cunliffe, F. Blouzon, Vincent Hedberg, G. Knies, A. Wegner, Paul Richard Newman, Grzegorz Nowak, Emmanuel Monnier, C. Jacobsson, L. R. West, S. Kermiche, Michael Schulz, J. M. Foster, P. Štefan, J-P. Meyer, W. von Schlippe, Leif J. Jönsson, E. Deffur, M. Lemler, T. Köhler, M. W. Krasny, Vladimir Andreev, J. Heatherington, H. Ziaeepour, E. Panaro, J. Kurzhöfer, T. Merz, M. Ibbotson, J. Duboc, B. Stella, D. Hammer, S. Kasarian, Leith Godfrey, P. Ribarics, V. Nagovizin, A. W. E. Dann, L. Laptin, S. Mani, R. Felst, J. Haack, G. Martin, S. Levonian, K. Stephens, H. P. Beck, J.M. Morton, P. Kostka, H. Greif, R. Eichler, I. O. Skillicorn, J.P. Lottin, H. Lohmander, Derek L. G. Hill, V. Efremenko, S. Eichenberger, H. B. Dreis, J. P. Kubenka, U. Gensch, J. H. Köhne, J. Huber, R. Kaschowitz, R. Bernier, D. Newton, K. Zuber, A. Lebedev, Stephen Burke, M. Eberle, J. Staeck, E. Peppel, D. Handschuh, M. Wagener, W. Hildesheim, J. Ferencei, Roland Horisberger, M. Colombo, M. Rietz, S. Aid, K. Flamm, D. Imbault, M. David, Murrough Landon, R.L. Chase, A. E. Wright, H. Krehbiel, A. Valkárová, A. Mavroidis, G. Kemmerling, V. Tchudakov, G. W. Noyes, G. Siegmon, A. Pieuchot, S. Mikocki, M. Seman, K. Rüter, S. Riess, F. Zomer, A. M. Goodall, H. T. Blume, F. Charles, R. Beyer, L. Del Buono, I. Sheviakov, E. Malinovski, M. Kuhlen, U. Dretzler, K. Hangarter, U. Kathage, E. Eisenhandler, D. Haidt, D. Breton, J. Moreels, J. Cvach, K. Thiele, C. Niebuhr, C. Gregory, S. Egli, P. Lanius, K. Gadow, A. Reboux, P. I. P. Kalmus, B. Laforge, Mikhail Danilov, D. Lewin, H. Steiner, Th. Wolff, R. Roosen, D. Kant, F. Moreau, J. Hladký, J. D. Dowell, Zhen Zhang, Y. Soloviev, H. Itterbeck, S. Peters, P. Van Mechelen, M. Charlet, M. Rudowicz, G. Heinzelmann, P E. Hatton, I. Abt, F. Ould-Saada, G. Buschhorn, H. I. Cronström, Z.Y. Feng, U. Lenhardt, U. Harder, V. Tchernyshov, H.-J. Küsel, P. Hill, Steve McMahon, Kerstin Borras, U. Krüger, J.F. Huppert, M. Kolander, Carl R. Brune, M. Barth, E. Gabathuler, J. David, J. Bán, F. Descamps, M. Fleischer, T. R. Ebert, A. Semenov, H. Shooshtari, A. Jacholkowska, J. Martyniak, S. Dagoret, C. A. Meyer, R. J. Thompson, Yves Sirois, H. U. Martyn, A. Busata, A. Fedotov, Günter Flügge, U. Seehausen, T. P. Yiou, U. Krüner-Marquis, M. Vecko, J. C. Biasci, I. W. Walker, I. R. Kenyon, T. Novák, D. Mercer, F. Sefkow, H. Spitzer, A. Gruber, H. Küster, G. Kantel, N. Lugetski, G. Bertrand-Coremans, M. C. Cousinou, K. Johannsen, M. Urban, V I. Shekelyan, R. Haydar, B. Fominykh, A. Leuschner, Christoph Grab, Nicolas Ellis, A. Rudge, P. Fuhrmann, J. Lipinski, C. Zeitnitz, E. Wünsch, K. Wacker, R. Steinberg, A. Nepeipivo, Christophe Royon, M. Korn, K. Ludwig, B. Liss, G. Falley, S. Masson, E. Barrelet, Dave Sankey, P. Burmeister, P. Dingus, F. Krivan, A. Usik, Ch. Ley, J. Feltesse, L. Criegee, G. Franke, A. De Roeck, F. Brasse, L. Goerlich, D. Gillespie, Richard E. Taylor, Michel Devel, B. Naroska, T. Jansen, Emmanuelle Perez, Winston Ko, G. Weber, Björn Lundberg, P. Hartz, V. Masbender, M. Kubantsev, J.F. Connolly, Max Klein, R. J. Ellison, L. Urban, U. Straumann, F. Dupont, C. Pascaud, G. D. Patel, H. Meyer, R. von Staa, S. Rusakov, L. Van Lancker, Dusan Bruncko, P. Nayman, W. Pimpl, Ch. Berger, F. Ferrarotto, H. Henschel, A. Gellrich, U. Berthon, F. Lamarche, T. Kurča, G. Rädel, J. Schütt, A. Drescher, N. Magnussen, Guenter Eckerlin, R. Vick, D.P. Johnson, M. Jaffre, J. E. Olsson, P. Jean, L. Gosset, H. Genzel, W. Fröchtenicht, S. A. Murray, W. Bartel, B. Koppitz, M. Hampel, B. Kuznik, J. Formánek, N. Sahlmann, E. Schuhmann, H. Brettel, P. A. Smirnov, K. Meier, C. Beigbeder, Ph. Huet, K. Tröger, C. Trenkel, G. Reinmuth, Wolfgang Scobel, D. Darvill, P. Biddulph, P. Binko, R. Ebbinghaus, J. Koch, L. Büngener, Ch. Pichler, D. Bederede, J. Martens, H. Laskus, M. Flieser, Kaori Maeshima, F. Kole, Martin Erdmann, Eckhart Fretwurst, J. Stier, J. V. Morris, D. A. Cragg, D. Newman-Coburn, Hermann Kolanoski, Jan Godlewski, M. A. Jabiol, G. Villet, S. Schleif, U. Obrock, J. Marks, F. Niebergall, V. Korbel, Pierre Marage, G. Schmidt, Y. Vazdik, D. Clarke, G. A. Beck, J. Garvey, F. W. Büsser, R B. Hopes, John A Coughlan, A. Coville, R. C. W. Henderson, U. Cornett, C. Vallée, Elzbieta Banas, Rosario Martín, P. Goritchev, A. Epifantsev, H. Quehl, A. M. Fomenko, U. Pein, K. Gamerdinger, Horst Oberlack, Vladimir Rusinov, L. Smolik, H. K. Nguyen, I. Herynek, P. Perrodo, Pavel Shatalov, W. Tribanek, J. Tutas, R. D. Appuhn, W. Braunschweig, M. Forbush, I. V. Gorelov, K. Müller, A. Schwind, R. Sell, S. Tapprogge, W.D. Dau, M. Vanderkelen, D. Lüers, J. D. Burger, Petr Zavada, P. Weissbach, E. Elsen, R. Prosi, Pavel Murin, V. Brisson, H. Grässler, Pavel Staroba, C. Arnault, B. Dulny, A. Courau, J. B. Dainton, C. Paulot, J. Spalek, I. Tichomirov, L.A. Womersley, Claire Bourdarios, R. Grässler, Ch. Coutures, W. Struczinski, Stephen Maxfield, J L. Mills, P. Verrecchia, P. Škvařil, C R. Hedgecock, D. Neyret, N. Huot, U. Siewert, R. L. Lander, H. Bärwolff, J. Stiewe, S. Palanque, A. Rostovtsev, Claus Kleinwort, J. Fent, M. Gennis, B W H. Edwards, V. Schröder, G. Van Beek, A. B. Clegg, Andrew Mehta, J. Riedlberger, H. H. Kaufmann, N. Gogitidze, M. Zimmer, C. Gruber, A. Patoux, M. Nyberg, J. Harjes, S. M. Robertson, A. Walther, W. Flauger, Jean-Francois Laporte, Laurent Favart, Z. Szkutnik, J. Turnau, M. Ruffer, G. Ernst, S. Orenstein, W. Zimmermann, B E. Wyborn, M. Steenbock, I. Giesgen, C. Dollfus, R. Bernard, P. Pailler, J. Ebert, B. Andrieu, A. Strowbridge, H. Hufnagel, Daniel Pitzl, K. Geske, J. Koll, Frank Raupach, K. Finke, S. Günther, S. K. Kotelnikov, L. Hajduk, N. Wulff, A. Perus, Ulrich Goerlach, P. Kasselmann, E. Evrard, Peter Loch, J. Gayler, C.D. Hilton, U. Buchner, G. Lindström, M. Turiot, A. Porrovecchio, B. Delcourt, U. Stösslein, M. Grewe, B. Montes, C. Leverenz, R. Marshall, Dirk Krücker, O. Hamon, V. Bidoli, P. Baranov, D.E. Baynham, V. Commichau, G. Cozzika, Peter Schleper, P. Röpnack, F. Eisele, A. Lindner, J. Janoth, Marc Besancon, A.S. Belousov, J.P. Phillips, Stefan Valkar, P. Truöl, F. Basti, H T. Phillips, Volker Blobel, C. Keuker, Hannes Jung, D. Schmidt, K. Rosenbauer, M. Haguenauer, Peter Schacht, G. C. Lopez, Rudolf Langkau, W. Schmitz, M. Savitski, E. Vogel, Gregorio Bernardi, V. Boudry, Anton Babaev, C. Thiebaux, A. Ducorps, J. Strachota, Jean Sacton, G. Thompson, A. Cyz, H. Riege, D. Düllmann, H. J. Behrend, J.C. Bizot, M. Goldberg, Peter Robmann, J. Šťastný, V. Riech, O. Dünger, M. Hapke, R. Gerhards, P. E. Reimer, Alan Campbell, E. M. Hanlon, J. Jeanjean, G. G. Winter, G. Grindhammer, P. Steffen, Jolanta Olszowska, D. Zarbock, H. P. Wellisch, T. Carli, K. Rauschnabel, Wolfgang Lange, E. Binder, E. Sanchez, D. Sole, S. Prell, I F. Fensome, S. Reinshagen, C. Kiesling, T. Kobler, R J. Day, K. Djiki, T. Külper, S. Karstensen, N. Schirm, M. Arpagaus, K. Rybicki, C. Schmidt, J. P. Sutton, W. Glasgow, Wolfram Erdmann, T. Ahmed, J. Meissner, D. Feeken, J.Y. Parey, S. Willard, H. Schmücker, M. Winde, J. P. Pharabod, L. Johnson, J.M. Baze, F. Martin, V. Lubimov, A. Hrisoho, Kerec, Hélène, Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), H1, Laboratoire de l'Accélérateur Linéaire ( LAL ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Physique des Particules de Marseille ( CPPM ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Aix Marseille Université ( AMU ), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Elementary Particle Physics, and Vrije Universiteit Brussel

Subjects
Physics, Nuclear and High Energy Physics, Luminosity (scattering theory), Calorimeter (particle physics), [PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, Detector, HERA, Tracking (particle physics), 7. Clean energy, 01 natural sciences, Nuclear physics, [ PHYS.HEXP ] Physics [physics]/High Energy Physics - Experiment [hep-ex], 0103 physical sciences, Calibration, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], High Energy Physics::Experiment, 010306 general physics, Instrumentation, Storage ring, Muon detector
Abstract

Technical aspects of the three major components of the H1 detector at the electron-proton storage ring HERA are described. This paper covers the detector status up to the end of 1994 when a major upgrading of some of its elements was undertaken. A description of the other elements of the detector and some performance figures from luminosity runs at HERA during 1993 and 1994 are given in a paper previously published in this journal.

Published
1997

49. Oral Vitamin D Rapidly Attenuates Inflammation from Sunburn: An Interventional Study

Author

Scott, Jeffrey F., Das, Lopa M., Ahsanuddin, Sayeeda, Qiu, Yuqi, Binko, Amy M., Traylor, Zachary P., Debanne, Sara M., Cooper, Kevin D., Boxer, Rebecca, and Lu, Kurt Q.

Abstract

The diverse immunomodulatory effects of vitamin D are increasingly being recognized. However, the ability of oral vitamin D to modulate acute inflammation in vivo has not been established in humans. In a double-blinded, placebo-controlled interventional trial, 20 healthy adults were randomized to receive either placebo or a high dose of vitamin D3(cholecalciferol) one hour after experimental sunburn induced by an erythemogenic dose of UVR. Compared with placebo, participants receiving vitamin D3(200,000 international units) demonstrated reduced expression of proinflammatory mediators tumor necrosis factor-α (P = 0.04) and inducible nitric oxide synthase (P = 0.02) in skin biopsy specimens 48 hours after experimental sunburn. A blinded, unsupervised hierarchical clustering of participants based on global gene expression profiles revealed that participants with significantly higher serum vitamin D3levels after treatment (P = 0.007) demonstrated increased skin expression of the anti-inflammatory mediator arginase-1 (P = 0.005), and a sustained reduction in skin redness (P = 0.02), correlating with significant expression of genes related to skin barrier repair. In contrast, participants with lower serum vitamin D3levels had significant expression of proinflammatory genes. Together the data may have broad implications for the immunotherapeutic properties of vitamin D in skin homeostasis, and implicate arginase-1 upregulation as a previously unreported mechanism by which vitamin D exerts anti-inflammatory effects in humans.

Published
2017
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50. Selective Publication Within Vascular Surgery: Characteristics of Discontinued and Unpublished Randomized Clinical Trials

Author

Binko, Mary A., Reitz, Katherine M., Chaer, Rabih A., Haga, Lindsey M., Go, Catherine, Alie-Cusson, Fanny S., Tzeng, Edith, Eslami, Mohammad H., and Sridharan, Natalie D.

Abstract

Discontinued and unpublished randomized clinical trials (RCT) are common resulting in biased publication and loss of potential knowledge. The magnitude of selective publication within vascular surgery remains unknown.

Published
2023
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