Search

The Wallace Foundation commissioned Research for Action and McClanahan Associates to study how out-of-school time intermediaries (OSTIs) responded to the COVID-19 pandemic and the role they could play in supporting communities moving forward. Citywide out-of-school time (OST) systems encompass a wide variety of afterschool and summer programs and associated provider organizations, youth participants, and their families. These systems were stretched during the COVID-19 pandemic and the national racial reckoning to respond to community needs in new and more equitable ways. Also impacted were OSTIs that manage OST systems within individual cities. OSTIs operate through various governance structures and perform a range of coordination functions intended to ensure quality, access, and equity in OST systems so that all youth have access to the unique out-of-school resources and opportunities they need to thrive.

Research and development work in artificial intelligence in education (AIED) is wide ranging and rapidly growing to support all areas of science, technology, engineering, and mathematics (STEM) teaching and learning. At the risk of hyperbole, this is potentially the most fundamentally game-changing technology for education to emerge since the internet. Building from decades of work on AI and AI-based learning and teaching technologies, the recent advances in AIED are pushing us to reimagine what is possible for STEM teaching and learning. AIED research initiatives are being speedily funded, and AIED advances are quickly becoming integrated into STEM education. It is transforming how teachers teach and how students learn. It is also transforming how education developers and researchers conduct their expansive work. There is excitement about the promise of AIED as well as growing concern that the breakthroughs in AIED are impacting everyday education practice in ways that may perpetuate long-standing biases and diminish the potential for positive outcomes. This brief is the first in a three-part series on AIED related to STEM research, teaching, and learning. The topics address ethical approaches to AI in STEM education research, AI for STEM teaching, and AI for STEM learning. This series is sponsored by the Community for Advancing Discovery Research in Education (CADRE), a National Science Foundation-funded network for STEM education researchers endeavoring to improve STEM teaching and learning through research, development, and various information-sharing and community-building mechanisms. Researchers in the CADRE network are part of a portfolio of projects funded through NSF's Discovery Research PreK-12 (DRK-12) program. The DRK-12 portfolio is wide-ranging, with a multitude of projects that focus on applied research and development to generate innovative research-informed and field-tested tools, products, and approaches that are intended to enhance STEM teaching and learning. Over the past several years, the portfolio has grown to include an increasing number of projects that leverage AIED to achieve their goals related to teaching or learning. It is expected to continue to grow. This series has been inspired by the question, "What are the essential considerations for researchers and developers who are designing, studying, and using AI in K-12 STEM?" Our hope is that the opportunities and challenges discussed in this series will generate reflection and rich discussion for the better and support the transformative use of AI to achieve positive and wide-reaching impact for all learners. In this first brief, "Toward Ethical and Just AI in Education Research," the authors are concerned with the ethical reasoning and decisions made in the development, study, and use of AIED technologies. Recognizing that AIED technologies reflect both the intended and unintended biases of the designers and the wider society, they advocate for the adoption of policies and practices that prioritize ethics, equity, and justice in research and development initiatives using AIED technologies in K-12 education. In an effort to provide guidance to researchers and developers, they lay the groundwork for responsible AI research and its implementation in educational settings. This foundation draws in part from the ethics rules for research with human subjects that have guided researchers for decades, but goes beyond this to frame a more all-encompassing stance rooted in justice and equity. The authors illustrate how ethical AI research can be strengthened by building from well-established ethical principles used in research and society at large. Taking into account these principles, they propose an ethical AIED framework and a set of tools that they have found to be supportive of continuous reflection, communication, and improvement toward inclusive and equitable AIED research and development. Their guidance is in the service of ensuring that the good intentions of researchers and developers will lead to positive design decisions and actions that create inclusive AIED technology products and systems. This is a valuable contribution that encourages a shift in focus to bring ethics, justice, and the values of communities of teachers, students, and families to the forefront of research and development practice.

We investigate the impact of CO$_2$ on TRAPPIST-1 e, f and g during the magma ocean stage. These potentially habitable rocky planets are currently the most accessible for astronomical observations. A constraint on the volatile budget during the magma ocean stage is a link to planet formation and also needed to judge their habitability. We perform simulations with 1-100 terrestrial oceans (TO) of H$_2$O with and without CO$_2$ and for albedos 0 and 0.75. The CO$_2$ mass is scaled with initial H$_2$O by a constant factor between 0.1 and 1. The magma ocean state of rocky planets begins with a CO$_2$-dominated atmosphere but can evolve into a H$_2$O dominated state, depending on initial conditions. For less than 10 TO initial H$_2$O, the atmosphere tends to desiccate and the evolution may end with a CO$_2$ dominated atmosphere. Otherwise, the final state is a thick (>1000 bar) H$_2$O-CO$_2$ atmosphere. Complete atmosphere desiccation with less than 10 TO initial H$_2$O can be significantly delayed for TRAPPIST-1e and f, when H$_2$O has to diffuse through a CO$_2$ atmosphere to reach the upper atmosphere, where XUV photolysis occurs. As a consequence of CO$_2$ diffusion-limited water loss, the time of mantle solidification for TRAPPIST-1 e, f, and g can be significantly extended compared to a pure H$_2$O evolution by up to 40 Myrs for albedo 0.75 and by up to 200 Mrys for albedo 0. The addition of CO$_2$ further results in a higher water content in the melt during the magma ocean stage. Our compositional model adjusted for the measured metallicity of TRAPPIST-1 yields for the dry inner planets (b, c, d) an iron fraction of 27 wt-%. For TRAPPIST-1 e, this iron fraction would be compatible with a (partly) desiccated evolution scenario and a CO$_2$ atmosphere with surface pressures of a few 100 bar. A comparative study between TRAPPIST-1 e and the inner planets may yield the most insights about formation and evolution scenarios., Comment: 36 pages, 28 figues, accepted by A&A 9/12/2024

In this paper we present our submission for the NorSID Shared Task as part of the 2025 VarDial Workshop (Scherrer et al., 2025), consisting of three tasks: Intent Detection, Slot Filling and Dialect Identification, evaluated using data in different dialects of the Norwegian language. For Intent Detection and Slot Filling, we have fine-tuned a multitask model in a cross-lingual setting, to leverage the xSID dataset available in 17 languages. In the case of Dialect Identification, our final submission consists of a model fine-tuned on the provided development set, which has obtained the highest scores within our experiments. Our final results on the test set show that our models do not drop in performance compared to the development set, likely due to the domain-specificity of the dataset and the similar distribution of both subsets. Finally, we also report an in-depth analysis of the provided datasets and their artifacts, as well as other sets of experiments that have been carried out but did not yield the best results. Additionally, we present an analysis on the reasons why some methods have been more successful than others; mainly the impact of the combination of languages and domain-specificity of the training data on the results., Comment: Vardial 2025 NorSID Shared Task

Spectroscopy and direct-imaging of ultra-faint targets such as Earth-like exoplanets and high redshift galaxies are among the primary goals of upcoming large scale astronomy projects like the Habitable World Observatory (HWO). Such objectives pose extreme instrumental challenges, in particular on detectors where dark currents lower than 1 e-/pixel/kilosecond and read noise less than 1 e-/pixel/frame will have to be achieved on large format arrays. Some technologies meet these requirements at optical wavelengths, but none do in the infrared. With this goal in mind, the University of Hawaii has partnered with Leonardo to develop linear-mode avalanche photodiodes (LmAPDs). In this paper, we report recent tests performed on LmAPDs, where we measure a ROIC glow of approximately 0.01 e-/pixel/frame, without which the intrinsic dark current is essentally zero (< 0.1 e- /pixel/kilosecond). We show that at high gain, these devices are capable of detecting single photons, Comment: Proceedings of SPIE Vol. 13103, 1310320 (2024)

The earliest stages of star and cluster formation are hidden within dense cocoons of gas and dust, limiting their detection at optical wavelengths. With the unprecedented infrared capabilities of JWST, we can now observe dust-enshrouded star formation with $\sim$10 pc resolution out to $\sim$20 Mpc. Early findings from PHANGS-JWST suggest that 3.3 $\mu$m polycyclic aromatic hydrocarbon (PAH) emission can identify star clusters in their dust-embedded phases. Here, we extend this analysis to 19 galaxies from the PHANGS-JWST Cycle 1 Treasury Survey, providing the first characterization of compact sources exhibiting 3.3$\mu$m PAH emission across a diverse sample of nearby star-forming galaxies. We establish selection criteria, a median color threshold of F300M-F335M=0.67 at F335M=20, and identify of 1816 sources. These sources are predominantly located in dust lanes, spiral arms, rings, and galaxy centers, with $\sim$87% showing concentration indices similar to optically detected star clusters. Comparison with the PHANGS-HST catalogs suggests that PAH emission fades within $\sim$3 Myr. The H$\alpha$ equivalent width of PAH emitters is 1-2.8 times higher than that of young PHANGS-HST clusters, providing evidence that PAH emitters are on average younger. Analysis of the bright portions of luminosity functions (which should not suffer from incompleteness) shows that young dusty clusters may increase the number of optically visible $\leq$ 3 Myr-old clusters in PHANGS-HST by a factor between $\sim$1.8x-8.5x., Comment: Submitted to ApJ

The co-occurrence of multiple long-term conditions (MLTC), or multimorbidity, in an individual can reduce their lifespan and severely impact their quality of life. Exploring the longitudinal patterns, e.g. clusters, of disease accrual can help better understand the genetic and environmental drivers of multimorbidity, and potentially identify individuals who may benefit from early targeted intervention. We introduce $\textit{probabilistic modelling of onset times}$, or $\texttt{ProMOTe}$, for clustering and forecasting MLTC trajectories. $\texttt{ProMOTe}$ seamlessly learns from incomplete and unreliable disease trajectories that is commonplace in Electronic Health Records but often ignored in existing longitudinal clustering methods. We analyse data from 150,000 individuals in the UK Biobank and identify 50 clusters showing patterns of disease accrual that have also been reported by some recent studies. We further discuss the forecasting capabilities of the model given the history of disease accrual.

We present numerous aspects of the evolution of the LP 890-9 (SPECULOOS-2/TOI-4306) planetary system, focusing on the likelihood that planet c can support life. We find that the host star reaches the main sequence in 1 Gyr and that planet c lies close to the inner boundary of the habitable zone. We find the magma ocean stage can last up to 50 Myr, remove 8 Earth-oceans of water, and leave up to 2000 bars of oxygen in the atmosphere. However, if the planet forms with a hydrogen envelope as small as 0.1 Earth-masses, no water will be lost during the star's pre-main sequence phase from thermal escape processes. We find that the planets are unlikely to be in a 3:1 mean motion resonance and that both planets tidally circularize within 0.5 Gyr when tidal dissipation is held constant. However, if tidal dissipation is a function of mantle temperature and rheology, then we find that planet c's orbit may require more than 7 Gyr to circularize, during which time tidal heating may reach hundreds of terawatts. We thus conclude that the habitability of planet c depends most strongly on the initial volatile content and internal properties, but no data yet preclude the viability of an active biosphere on the planet., Comment: 16 pages, 9 figures, accepted to PSJ

Electronic healthcare records (EHR) contain a huge wealth of data that can support the prediction of clinical outcomes. EHR data is often stored and analysed using clinical codes (ICD10, SNOMED), however these can differ across registries and healthcare providers. Integrating data across systems involves mapping between different clinical ontologies requiring domain expertise, and at times resulting in data loss. To overcome this, code-agnostic models have been proposed. We assess the effectiveness of a code-agnostic representation approach on the task of long-term microvascular complication prediction for individuals living with Type 2 Diabetes. Our method encodes individual EHRs as text using fine-tuned, pretrained clinical language models. Leveraging large-scale EHR data from the UK, we employ a multi-label approach to simultaneously predict the risk of microvascular complications across 1-, 5-, and 10-year windows. We demonstrate that a code-agnostic approach outperforms a code-based model and illustrate that performance is better with longer prediction windows but is biased to the first occurring complication. Overall, we highlight that context length is vitally important for model performance. This study highlights the possibility of including data from across different clinical ontologies and is a starting point for generalisable clinical models., Comment: Findings paper presented at Machine Learning for Health (ML4H) symposium 2024, December 15-16, 2024, Vancouver, Canada, 9 pages

We uncover new features of generalized contextuality by connecting it to the Kirkwood-Dirac (KD) quasiprobability distribution. Quantum states can be represented by KD distributions, which take values in the complex unit disc. Only for ``KD-positive'' states are the KD distributions joint probability distributions. A KD distribution can be measured by a series of weak and projective measurements. We design such an experiment and show that it is contextual iff the underlying state is not KD-positive. We analyze this connection with respect to mixed KD-positive states that cannot be decomposed as convex combinations of pure KD-positive states. Our result is the construction of a noncontextual experiment that enables an experimenter to verify contextuality., Comment: 17 pages, 4 figures

Reconstructing continuous surfaces from unoriented and unordered 3D points is a fundamental challenge in computer vision and graphics. Recent advancements address this problem by training neural signed distance functions to pull 3D location queries to their closest points on a surface, following the predicted signed distances and the analytical gradients computed by the network. In this paper, we introduce NumGrad-Pull, leveraging the representation capability of tri-plane structures to accelerate the learning of signed distance functions and enhance the fidelity of local details in surface reconstruction. To further improve the training stability of grid-based tri-planes, we propose to exploit numerical gradients, replacing conventional analytical computations. Additionally, we present a progressive plane expansion strategy to facilitate faster signed distance function convergence and design a data sampling strategy to mitigate reconstruction artifacts. Our extensive experiments across a variety of benchmarks demonstrate the effectiveness and robustness of our approach. Code is available at https://github.com/CuiRuikai/NumGrad-Pull, Comment: 10 pages, 5 figures

How Supernova Remnant (SNR) shocks impact nearby molecular clouds is still poorly observationally constrained. It is unclear if SNRs can positively or negatively affect clouds star formation potential. We have studied the dense gas morphology and kinematics toward the Infrared Dark Cloud (IRDC) G034.77-00.55, shock-interacting with the SNR W44, to identify evidence of early stage star formation induced by the shock. We have used high-angular resolution N2H+(1-0) images across G034.77-00.55, obtained with ALMA. N2H+ is a well known tracer of dense and cold material, optimal to identify gas with the highest potential to harbour star formation. The N2H+ emission is distributed into two elongated structures, one toward the dense ridge at the edge of the source and one toward the inner cloud. Both elongations are spatially associated with well-defined mass-surface density features. The velocities of the gas in the two structures i.e., 38-41 km s-1 and 41-43 km s-1 are consistent with the lowest velocities of the J- and C-type parts of the SNR-driven shock, respectively. A third velocity component is present at 43-45.5 km s-1. The dense gas shows a fragmented morphology with core-like fragments of scales consistent with the Jeans lengths, masses $\sim$1-20 M$_{\odot}$, densities (n(H$_2$)$\geq$10$^5$ cm$^{-3}$) sufficient to host star formation in free-fall time scales (few 10$^4$ yr) and with virial parameters that hint toward possible collapse. The W44 driven shock may have swept up the encountered material which is now seen as a dense ridge, almost detached from the main cloud, and an elongation within the inner cloud, well constrained in both N2H+ emission and mass surface density. This shock compressed material may have then fragmented into cores that are either in a starless or pre-stellar stage. Additional observations are needed to confirm this scenario and the nature of the cores., Comment: 12 pages, 8 figures, accepted for publication in A&A

Frontier AI safety policies highlight automation of AI research and development (R&D) by AI agents as an important capability to anticipate. However, there exist few evaluations for AI R&D capabilities, and none that are highly realistic and have a direct comparison to human performance. We introduce RE-Bench (Research Engineering Benchmark, v1), which consists of 7 challenging, open-ended ML research engineering environments and data from 71 8-hour attempts by 61 distinct human experts. We confirm that our experts make progress in the environments given 8 hours, with 82% of expert attempts achieving a non-zero score and 24% matching or exceeding our strong reference solutions. We compare humans to several public frontier models through best-of-k with varying time budgets and agent designs, and find that the best AI agents achieve a score 4x higher than human experts when both are given a total time budget of 2 hours per environment. However, humans currently display better returns to increasing time budgets, narrowly exceeding the top AI agent scores given an 8-hour budget, and achieving 2x the score of the top AI agent when both are given 32 total hours (across different attempts). Qualitatively, we find that modern AI agents possess significant expertise in many ML topics -- e.g. an agent wrote a faster custom Triton kernel than any of our human experts' -- and can generate and test solutions over ten times faster than humans, at much lower cost. We open-source the evaluation environments, human expert data, analysis code and agent trajectories to facilitate future research.

Transitioning from quantum computation on physical qubits to quantum computation on encoded, logical qubits can improve the error rate of operations, and will be essential for realizing valuable quantum computational advantages. Using a neutral atom quantum processor with 256 qubits, each an individual Ytterbium atom, we demonstrate the entanglement of 24 logical qubits using the distance-two [[4,2,2]] code, simultaneously detecting errors and correcting for lost qubits. We also implement the Bernstein-Vazirani algorithm with up to 28 logical qubits encoded in the [[4,1,2]] code, showing better-than-physical error rates. We demonstrate fault-tolerant quantum computation in our approach, guided by the proposal of Gottesman (2016), by performing repeated loss correction for both structured and random circuits encoded in the [[4,2,2]] code. Finally, since distance-two codes can correct qubit loss, but not other errors, we show repeated loss and error correction using the distance-three [[9,1,3]] Bacon-Shor code. These results begin to clear a path for achieving scientific quantum advantage with a programmable neutral atom quantum processor., Comment: 17 pages, 16 figures

Arrays of optically trapped neutral atoms are a promising architecture for the realization of quantum computers. In order to run increasingly complex algorithms, it is advantageous to demonstrate high-fidelity and flexible gates between long-lived and highly coherent qubit states. In this work, we demonstrate a universal high-fidelity gate-set with individually controlled and parallel application of single-qubit gates and two-qubit gates operating on the ground-state nuclear spin qubit in arrays of tweezer-trapped $^{171}$Yb atoms. We utilize the long lifetime, flexible control, and high physical fidelity of our system to characterize native gates using single and two-qubit Clifford and symmetric subspace randomized benchmarking circuits with more than 200 CZ gates applied to one or two pairs of atoms. We measure our two-qubit entangling gate fidelity to be 99.72(3)% (99.40(3)%) with (without) post-selection. In addition, we introduce a simple and optimized method for calibration of multi-parameter quantum gates. These results represent important milestones towards executing complex and general quantum computation with neutral atoms.

Spectroscopy of Earth-like exoplanets and ultra-faint galaxies are priority science cases for the coming decades. Here, broadband source flux rates are measured in photons per square meter per hour, imposing extreme demands on detector performance, including dark currents lower than \mbox{1 e-/pixel/kilosecond}, read noise less than \mbox{1 e-/pixel/frame}, and large formats. There are currently no infrared detectors that meet these requirements. The University of Hawai'i and industrial partners are developing one promising technology, linear mode avalanche photodiodes (LmAPDs), which is on track to meet the above-mentioned requirements. We present progress towards developing a science-grade, megapixel format linear-mode avalanche photodiode array for low background shortwave (1 - 2.4 um) infrared astronomy. Our latest results show outstanding performance, with dark current \textless 1e-4 electrons/pixel/second and read noise reducing by 30\% per volt of bias, reaching less than 1e-/pixel/frame in correlated double-sampling, and able to average down to $\sim$0.3 e-/pixel/frame when using multiple non-destructive reads. We present some on-sky data as well as comment on prospects for photon number resolving capability., Comment: SPIE Astronomical Telescopes + Instrumentation 2024, PROC#13103-25. arXiv admin note: text overlap with arXiv:2208.11834

Understanding the temporal properties of longitudinal data is critical for identifying trends, predicting future events, and making informed decisions in any field where temporal data is analysed, including health and epidemiology, finance, geosciences, and social sciences. Traditional time-series analysis techniques often fail to capture the complexity of irregular temporal patterns present in such data. To address this gap, we introduce bursty_dynamics, a Python package that enables the quantification of bursty dynamics through the calculation of the Burstiness Parameter (BP) and Memory Coefficient (MC). In temporal data, BP and MC provide insights into the irregularity and temporal dependencies within event sequences, shedding light on complex patterns of disease aetiology, human behaviour, or other information diffusion over time. An event train detection method is also implemented to identify clustered events occurring within a specified time interval, allowing for more focused analysis with reduced noise. With built-in visualisation tools, bursty_dynamics provides an accessible yet powerful platform for researchers to explore and interpret the temporal dynamics of longitudinal data. This paper outlines the core functionalities of the package, demonstrates its applications in diverse research domains, and discusses the advantages of using BP, MC, and event train detection for enhanced temporal data analysis.

In response to numerous programs seeking to advance quantum education and workforce development in the United States, experts from academia, industry, government, and professional societies convened for a National Science Foundation-sponsored workshop in February 2024 to explore the benefits and challenges of establishing a national center for quantum education. Broadly, such a center would foster collaboration and build the infrastructure required to develop a diverse and quantum-ready workforce. The workshop discussions centered around how a center could uniquely address gaps in public, K-12, and undergraduate quantum information science and engineering (QISE) education. Specifically, the community identified activities that, through a center, could lead to an increase in student awareness of quantum careers, boost the number of educators trained in quantum-related subjects, strengthen pathways into quantum careers, enhance the understanding of the U.S. quantum workforce, and elevate public engagement with QISE. Core proposed activities for the center include professional development for educators, coordinated curriculum development and curation, expanded access to educational laboratory equipment, robust evaluation and assessment practices, network building, and enhanced public engagement with quantum science.

Estimated brain age from magnetic resonance image (MRI) and its deviation from chronological age can provide early insights into potential neurodegenerative diseases, supporting early detection and implementation of prevention strategies. Diffusion MRI (dMRI), a widely used modality for brain age estimation, presents an opportunity to build an earlier biomarker for neurodegenerative disease prediction because it captures subtle microstructural changes that precede more perceptible macrostructural changes. However, the coexistence of macro- and micro-structural information in dMRI raises the question of whether current dMRI-based brain age estimation models are leveraging the intended microstructural information or if they inadvertently rely on the macrostructural information. To develop a microstructure-specific brain age, we propose a method for brain age identification from dMRI that minimizes the model's use of macrostructural information by non-rigidly registering all images to a standard template. Imaging data from 13,398 participants across 12 datasets were used for the training and evaluation. We compare our brain age models, trained with and without macrostructural information minimized, with an architecturally similar T1-weighted (T1w) MRI-based brain age model and two state-of-the-art T1w MRI-based brain age models that primarily use macrostructural information. We observe difference between our dMRI-based brain age and T1w MRI-based brain age across stages of neurodegeneration, with dMRI-based brain age being older than T1w MRI-based brain age in participants transitioning from cognitively normal (CN) to mild cognitive impairment (MCI), but younger in participants already diagnosed with Alzheimer's disease (AD). Approximately 4 years before MCI diagnosis, dMRI-based brain age yields better performance than T1w MRI-based brain ages in predicting transition from CN to MCI.

This study evaluates the generalisation capabilities of state-of-the-art histopathology foundation models on out-of-distribution multi-stain autoimmune Immunohistochemistry datasets. We compare 13 feature extractor models, including ImageNet-pretrained networks, and histopathology foundation models trained on both public and proprietary data, on Rheumatoid Arthritis subtyping and Sjogren's Disease detection tasks. Using a simple Attention-Based Multiple Instance Learning classifier, we assess the transferability of learned representations from cancer H&E images to autoimmune IHC images. Contrary to expectations, histopathology-pretrained models did not significantly outperform ImageNet-pretrained models. Furthermore, there was evidence of both autoimmune feature misinterpretation and biased feature importance. Our findings highlight the challenges in transferring knowledge from cancer to autoimmune histopathology and emphasise the need for careful evaluation of AI models across diverse histopathological tasks. The code to run this benchmark is available at https://github.com/AmayaGS/ImmunoHistoBench., Comment: Accepted at Workshop on Advancements In Medical Foundation Models (NeurIPS 2024)

Reinforcement learning problems often involve large action spaces arising from the simultaneous execution of multiple sub-actions, resulting in combinatorial action spaces. Learning in combinatorial action spaces is difficult due to the exponential growth in action space size with the number of sub-actions and the dependencies among these sub-actions. In offline settings, this challenge is compounded by limited and suboptimal data. Current methods for offline learning in combinatorial spaces simplify the problem by assuming sub-action independence. We propose Branch Value Estimation (BVE), which effectively captures sub-action dependencies and scales to large combinatorial spaces by learning to evaluate only a small subset of actions at each timestep. Our experiments show that BVE outperforms state-of-the-art methods across a range of action space sizes.

We remove the dependence on the `hot-spots' conjecture in two of the main theorems of the recent paper of Nickl (2024, Annals of Statistics). Specifically, we characterise the minimax convergence rates for estimation of the transition operator $P_{f}$ arising from the Neumann Laplacian with diffusion coefficient $f$ on arbitrary convex domains with smooth boundary, and further show that a general Lipschitz stability estimate holds for the inverse map $P_f\mapsto f$ from $H^2\to H^2$ to $L^1$.

Machine learning (ML) is a revolutionary technology with demonstrable applications across multiple disciplines. Within the Earth science community, ML has been most visible for weather forecasting, producing forecasts that rival modern physics-based models. Given the importance of deepening our understanding and improving predictions of the Earth system on all time scales, efforts are now underway to develop forecasting models into Earth-system models (ESMs), capable of representing all components of the coupled Earth system (or their aggregated behavior) and their response to external changes. Modeling the Earth system is a much more difficult problem than weather forecasting, not least because the model must represent the alternate (e.g., future) coupled states of the system for which there are no historical observations. Given that the physical principles that enable predictions about the response of the Earth system are often not explicitly coded in these ML-based models, demonstrating the credibility of ML-based ESMs thus requires us to build evidence of their consistency with the physical system. To this end, this paper puts forward five recommendations to enhance comprehensive, standardized, and independent evaluation of ML-based ESMs to strengthen their credibility and promote their wider use.

We present a series of 9 Doppler images of the magnetically active K component of the RS CVn-type binary SZ Psc, based on the high-resolution spectroscopic data collected from 2014 to 2018. We apply least-squares deconvolution to all spectra to extract the average profiles with high signal-to-noise ratios (SNRs) for Doppler imaging. The surface maps of the K subgiant show starspots widely distributed along latitude and longitude. A prominent, non-axisymmetric polar spot around phase 0 is revealed by all images with sufficient phase coverage, which may be a stable feature on the K component. The starspots evolve in a time scale of one month. We have determined the surface shear rate of the K component from the starspot maps reconstructed 10 days apart in 2017 Nov--Dec, through the cross-correlation method. The surface differential rotation parameters are $\Omega_{eq} = 1.591 \pm 0.002$ rad d$^{-1}$ and $\Delta \Omega = 0.035 \pm 0.003$ rad d$^{-1}$. The absorption lines contributed from the tertiary component are detected in all LSD profiles of SZ Psc, and we measure the radial velocity of the binary system and the tertiary component to derive an elliptical orbit with a period of $1530 \pm 3$ days and a mass of $0.75 \pm 0.06$ M$\odot$ for the tertiary component., Comment: 15 pages, 8 figures, accepted for publication in ApJ

The Central Molecular Zone (CMZ) is the largest reservoir of dense molecular gas in the Galaxy and is heavily obscured in the optical and near-IR. We present an overview of the far-IR dust continuum, where the molecular clouds are revealed, provided by Herschel in the inner 40\deg($|l| <$ 20\deg) of the Milky Way with a particular focus on the CMZ. We report a total dense gas ($N$(H$_2$) $> 10^{23}$ cm$^{-2}$) CMZ mass of M=$2\substack{+2 \\ -1} \times 10^7$ M$_{\odot}$ and confirm that there is a highly asymmetric distribution of dense gas, with about 70-75% at positive longitudes. We create and publicly release complete fore/background-subtracted column density and dust temperature maps in the inner 40\deg ($|l| <$ 20\deg) of the Galaxy. We find that the CMZ clearly stands out as a distinct structure, with an average mass per longitude that is at least $3\times$ higher than the rest of the inner Galaxy contiguously from 1.8\deg $> \ell >$ -1.3\deg. This CMZ extent is larger than previously assumed, but is consistent with constraints from velocity information. The inner Galaxy's column density peaks towards the SgrB2 complex with a value of about 2 $\times$ 10$^{24}$ cm$^{-2}$, and typical CMZ molecular clouds are about N(H$_2$)=10$^{23}$ cm$^{-2}$. Typical CMZ dust temperatures range from about $12-35$ K with relatively little variation. We identify a ridge of warm dust in the inner CMZ that potentially traces the base of the northern Galactic outflow seen with MEERKAT., Comment: Submitted to ApJ, 16 pages, project website: https://centralmolecularzone.github.io/3D_CMZ/

The Central Molecular Zone (CMZ) is the way station at the heart of our Milky Way Galaxy, connecting gas flowing in from Galactic scales with the central nucleus. Key open questions remain about its 3-D structure, star formation properties, and role in regulating this gas inflow. In this work, we identify a hierarchy of discrete structures in the CMZ using column density maps from Paper I (Battersby et al., submitted). We calculate the physical ($N$(H$_2$), $T_{\rm{dust}}$, mass, radius) and kinematic (HNCO, HCN, and HC$_3$N moments) properties of each structure as well as their bolometric luminosities and star formation rates (SFRs). We compare these properties with regions in the Milky Way disk and external galaxies. Despite the fact that the CMZ overall is well below the Gao-Solomon dense gas star-formation relation (and in modest agreement with the Schmidt-Kennicutt relation), individual structures on the scale of molecular clouds generally follow these star-formation relations and agree well with other Milky Way and extragalactic regions. We find that individual CMZ structures require a large external pressure ($P_e$/k$_B$ $> 10^{7-9}$ K cm$^{-3}$) to be considered bound, however simple estimates suggest that most CMZ molecular-cloud-sized structures are consistent with being in pressure-bounded virial equilibriuim. We perform power-law fits to the column density probability distribution functions (N-PDFs) of the inner 100 pc, SgrB2, and the outer 100 pc of the CMZ as well as several individual molecular cloud structures and find generally steeper power-law slopes ($-9<\alpha<-2$) compared with the literature ($-6 < \alpha < -1$)., Comment: Accepted to ApJ, 25 pages, project website: https://centralmolecularzone.github.io/3D_CMZ/

A comprehensive 3-D model of the central 300 pc of the Milky Way, the Central Molecular Zone (CMZ) is of fundamental importance in understanding energy cycles in galactic nuclei, since the 3-D structure influences the location and intensity of star formation, feedback, and black hole accretion. Current observational constraints are insufficient to distinguish between existing 3-D models. Dust extinction is one diagnostic tool that can help determine the location of dark molecular clouds relative to the bright Galactic Center emission. By combining Herschel and Spitzer observations, we developed three new dust extinction techniques to estimate the likely near/far locations for each cloud in the CMZ. We compare our results to four geometric CMZ orbital models. Our extinction methods show good agreement with each other, and with results from spectral line absorption analysis from Walker et al. (submitted). Our near/far results for CMZ clouds are inconsistent with a projected version of the Sofue (1995) two spiral arms model, and show disagreement in position-velocity space with the Molinari et al. (2011) closed elliptical orbit. Our results are in reasonable agreement with the Kruijssen et al. (2015) open streams. We find that a simplified toy-model elliptical orbit which conserves angular momentum shows promising fits in both position-position and position-velocity space. We conclude that all current CMZ orbital models lack the complexity needed to describe the motion of gas in the CMZ, and further work is needed to construct a complex orbital model to accurately describe gas flows in the CMZ., Comment: Submitted to ApJ; 36 pages; Project series website with relevant code, data, and results: https://centralmolecularzone.github.io/3D_CMZ/

The Milky Way's Central Molecular Zone (CMZ) is the largest concentration of dense molecular gas in the Galaxy, the structure of which is shaped by the complex interplay between Galactic-scale dynamics and extreme physical conditions. Understanding the 3-D geometry of this gas is crucial as it determines the locations of star formation and subsequent feedback. We present a catalogue of clouds in the CMZ using Herschel data. Using archival data from the APEX and MOPRA CMZ surveys, we measure averaged kinematic properties of the clouds at 1mm and 3mm. We use archival ATCA data of the H$_{2}$CO (1$_{1,0}$ - 1$_{1,1}$) 4.8 GHz line to search for absorption towards the clouds, and 4.85 GHz GBT C-band data to measure the radio continuum emission. We measure the absorption against the continuum to provide new constraints for the line-of-sight positions of the clouds relative to the Galactic centre, and find a highly asymmetric distribution, with most clouds residing in front of the Galactic centre. The results are compared with different orbital models, and we introduce a revised toy model of a vertically-oscillating closed elliptical orbit. We find that most models describe the PPV structure of the gas reasonably well, but find significant inconsistencies in all cases regarding the near vs. far placement of individual clouds. Our results highlight that the CMZ is likely more complex than can be captured by these simple geometric models, along with the need for new data to provide further constraints on the true 3-D structure of the CMZ., Comment: Submitted to ApJ, 30 pages, project website: https://centralmolecularzone.github.io/3D_CMZ/

Colonoscopy is currently one of the most sensitive screening methods for colorectal cancer. This study investigates the frontiers of intelligent colonoscopy techniques and their prospective implications for multimodal medical applications. With this goal, we begin by assessing the current data-centric and model-centric landscapes through four tasks for colonoscopic scene perception, including classification, detection, segmentation, and vision-language understanding. This assessment enables us to identify domain-specific challenges and reveals that multimodal research in colonoscopy remains open for further exploration. To embrace the coming multimodal era, we establish three foundational initiatives: a large-scale multimodal instruction tuning dataset ColonINST, a colonoscopy-designed multimodal language model ColonGPT, and a multimodal benchmark. To facilitate ongoing monitoring of this rapidly evolving field, we provide a public website for the latest updates: https://github.com/ai4colonoscopy/IntelliScope., Comment: [work in progress] A comprehensive survey of intelligent colonoscopy in the multimodal era

We present a quantum algorithm for portfolio optimisation. Specifically, We present an end-to-end quantum approximate optimisation algorithm (QAOA) to solve the discrete global minimum variance portfolio (DGMVP) model. This model finds a portfolio of risky assets with the lowest possible risk contingent on the number of traded assets being discrete. We provide a complete pipeline for this model and analyses its viability for noisy intermediate-scale quantum computers. We design initial states, a cost operator, and ans\"atze with hard mixing operators within a binary encoding. Further, we perform numerical simulations to analyse several optimisation routines, including layerwise optimisation, utilising COYBLA and dual annealing. Finally, we consider the impacts of thermal relaxation and stochastic measurement noise. We find dual annealing with a layerwise optimisation routine provides the most robust performance. We observe that realistic thermal relaxation noise levels preclude quantum advantage. However, stochastic measurement noise will dominate when hardware sufficiently improves. Within this regime, we numerically demonstrate a favourable scaling in the number of shots required to obtain the global minimum -- an indication of quantum advantage in portfolio optimisation., Comment: 35 pages, 23 figures

Data augmentation methods such as Copy-Paste have been studied as effective ways to expand training datasets while incurring minimal costs. While such methods have been extensively implemented for image level tasks, we found no scalable implementation of Copy-Paste built specifically for video tasks. In this paper, we leverage the recent growth in video fidelity of generative models to explore effective ways of incorporating synthetically generated objects into existing video datasets to artificially expand object instance pools. We first procure synthetic video sequences featuring objects that morph dynamically with time. Our carefully devised pipeline automatically segments then copy-pastes these dynamic instances across the frames of any target background video sequence. We name our video data augmentation pipeline Synthetic Dynamic Instance Copy-Paste, and test it on the complex task of Video Instance Segmentation which combines detection, segmentation and tracking of object instances across a video sequence. Extensive experiments on the popular Youtube-VIS 2021 dataset using two separate popular networks as baselines achieve strong gains of +2.9 AP (6.5%) and +2.1 AP (4.9%). We make our code and models publicly available.

Inspired by equivariant homotopy theory, equivariant algebra studies generalisations of G-Mackey functors that do not have all transfer maps (also known as induction maps), for G a finite group. These incomplete Mackey functors have interesting and subtle properties that are more complicated than classical algebra. The levels of incompleteness that occur are indexed by simple combinatorial data known as transfers systems for G, which are refinements of the subgroup relation satisfying certain axioms. The aim of this paper is to generalise the Greenlees-May and Thevenaz-Webb splitting result of rational G-Mackey functors to the incomplete case. By calculating idempotents of the rational incomplete Burnside ring of G, we find maximal splitting of the category of rational incomplete G-Mackey functors. These splittings are determined by maps of the form (H to G) in the transfer system. We give an intrinsic definition of the split pieces beyond the idempotent description in order to understand what is the minimal information needed to determine an arbitrary rational incomplete G-Mackey functor. We end the paper with a series of examples of possible splittings and illustrate how simpler transfer systems have fewer terms in the splitting but the split pieces are more complicated., Comment: 39 pages

The process of collecting blood from donors and making it available for transfusion requires a complex series of operations involving multiple actors and resources at each step. Ensuring hospitals receive adequate and safe blood for transfusion is a common challenge across low- and middle-income countries, but is rarely addressed from a system level. This paper presents the first use of discrete event simulation to study the blood system in Kenya and to explore the effect of variations and perturbations at different steps of the system on meeting patient blood demand. A process map of the Kenyan blood system was developed to capture critical steps from blood donation to transfusion using interviews with blood bank, hospital, and laboratory personnel at four public hospitals across three counties in Kenya. The blood system was simulated starting with blood collection, a blood bank where blood is tested and stored before it is issued, a major hospital attached to the blood bank, and several smaller hospitals served by the same blood bank. Values for supply-side parameters were based mainly on expert opinion; demand-side parameters were based on data from blood requisitions made in hospital wards, and dispatch of blood from the hospital laboratory. Illustrative examples demonstrate how the model can be used to explore the impacts of changes in blood collection (e.g., prioritising different donor types), blood demand (e.g., differing clinical case mix), and blood distribution (e.g., restocking strategies) on meeting demand at patient level. The model can reveal potential process impediments in the blood system and aid in choosing strategies for improving blood collection, distribution or use. Such a systems approach allows for interventions at different steps in the blood continuum to be tested on blood availability for different patients presenting at diverse hospitals across the country., Comment: 38 pages, 8 figures

Combining Atacama Large Millimeter/sub-millimeter Array CO(2-1) mapping and JWST near- and mid-infrared imaging, we characterize the relationship between CO(2-1) and polycyclic aromatic hydrocarbon (PAH) emission at ~100 pc resolution in 66 nearby star-forming galaxies, expanding the sample size from previous ~100 pc resolution studies by more than an order of magnitude. Focusing on regions of galaxies where most of the gas is likely to be molecular, we find strong correlations between CO(2-1) and 3.3 micron, 7.7 micron, and 11.3 micron PAH emission, estimated from JWST's F335M, F770W, and F1130W filters. We derive power law relations between CO(2-1) and PAH emission, which have indices in the range 0.8-1.2, implying relatively weak variations in the observed CO-to-PAH ratios across the regions that we study. We find that CO-to-PAH ratios and scaling relationships near HII regions are similar to those in diffuse sight lines. The main difference between the two types of regions is that sight lines near HII regions show higher intensities in all tracers. Galaxy centers, on the other hand, show higher overall intensities and enhanced CO-to-PAH ratios compared to galaxy disks. Individual galaxies show 0.19 dex scatter in the normalization of CO at fixed I_PAH and this normalization anti-correlates with specific star formation rate (SFR/M*) and correlates with stellar mass. We provide a prescription that accounts for these galaxy-to-galaxy variations and represents our best current empirical predictor to estimate CO(2-1) intensity from PAH emission, which allows one to take advantage of JWST's excellent sensitivity and resolution to trace cold gas., Comment: 21 pages, 4 figures, 3 tables. Submitted to ApJ

Quantum error correction (QEC) will be essential to achieve the accuracy needed for quantum computers to realise their full potential. The field has seen promising progress with demonstrations of early QEC and real-time decoded experiments. As quantum computers advance towards demonstrating a universal fault-tolerant logical gate set, implementing scalable and low-latency real-time decoding will be crucial to prevent the backlog problem, avoiding an exponential slowdown and maintaining a fast logical clock rate. Here, we demonstrate low-latency feedback with a scalable FPGA decoder integrated into the control system of a superconducting quantum processor. We perform an 8-qubit stability experiment with up to $25$ decoding rounds and a mean decoding time per round below $1$ ${\mu}s$, showing that we avoid the backlog problem even on superconducting hardware with the strictest speed requirements. We observe logical error suppression as the number of decoding rounds is increased. We also implement and time a fast-feedback experiment demonstrating a decoding response time of $9.6$ ${\mu}s$ for a total of $9$ measurement rounds. The decoder throughput and latency developed in this work, combined with continued device improvements, unlock the next generation of experiments that go beyond purely keeping logical qubits alive and into demonstrating building blocks of fault-tolerant computation, such as lattice surgery and magic state teleportation., Comment: 11 pages, 4 figures, Supplementary Information