275 results on '"P., Mariniello"'
Search Results
2. Sirtuins and Cellular Senescence in Patients with Idiopathic Pulmonary Fibrosis and Systemic Autoimmune Disorders
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D’Agnano, Vito, Mariniello, Domenica Francesca, Pagliaro, Raffaella, Far, Mehrdad Savabi, Schiattarella, Angela, Scialò, Filippo, Stella, Giulia, Matera, Maria Gabriella, Cazzola, Mario, Bianco, Andrea, and Perrotta, Fabio
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- 2024
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3. Potential role of SIRT-1 and SIRT-3 as biomarkers for the diagnosis and prognosis of idiopathic pulmonary fibrosis
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Perrotta, Fabio, D’Agnano, Vito, Mariniello, Domenica Francesca, Castaldo, Giuseppe, Vitale, Maria, Cazzola, Mario, Bianco, Andrea, and Scialò, Filippo
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- 2024
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4. Ergonomics in the operating room and surgical training: a survey on the Italian scenario
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Stefano Restaino, Marco D’Indinosante, Federica Perelli, Martina Arcieri, Vittorio Cherchi, Marco Petrillo, Anna Franca Cavaliere, Stefano Cianci, Giulia Pellecchia, Roberto Luca Meniconi, Alessandro Coppola, Vito Chiantera, Giovanni Scambia, Lorenza Driul, Giuseppe Vizzielli, SPIGC Working Group, Berton Federico, Conti Luigi, Formisano Giampaolo, Guaitoli Eleonora, Iossa Angelo, Maruccia Michele, Mazzari Andrea, Oragano Luigi, Pasculli Alessandro, Ratti Francesca, Serenari Matteo, Settembrini Alberto, Sirignano Pasqualino, Soriero Domenico, Vallicelli Carlo, Cianci (Sicilia) Stefano, Iaco (Puglia) Giulia De, Falcone (Campania) Francesca, Giaccari (Triveneto) Sara, Giovenzana (Lombardia) Marco, Pasqui (Toscana) Edoardo, Petrillo (Sardegna) Marco, Portigliotti (Piemonte) Luca, Sena (Calabria) Giuseppe, Sparavigna (Liguria) Marco, Bettini Giordana, Fanello Gianfranco, Mendogni Paolo, Monteleone Lorenzo, Pertile Nicoletta Pia Ardò Davide, Tomaiuolo Pasquina, Negrello Sara, Di Bartolomeo Mattia, Patini Romeo, Vito Marcuzzo Alberto, Campione Alberto, Comacchio Giovanni, Murana Giacomo, Antonio Martino, Manitto Mattia, Galzerano Giuseppe, Di Marco Carlo, Velluti Francesco, Berardi Gianmauro, Romboli Andrea, Weindelmejer Jacopo, Tamburrino Domenico, Calarco Alessandro, Losco Luigi, Nacchiero Eleonora, Elia Rossella, Torto Federico Lo, Vicenti Giovanni, Pappalardo Vincenzo, Pisani Dafne, Palmisano Graziano, Brascia Debora, Troisi Luigi, Renzi Federica, Melandro Fabio, Pecere Silvia, Gazia Carlo, Di Franco Gregorio, Romano Gaetano, Bolletta Alberto, Botteri Emanuele, Di Meo Giovanna, Ronsini Carlo, Chiappetta Sonia, Sgaramella Ilaria, Pennestri Francesco, Girardi Antonella, Mariniello Donatella, Marcasciano Marco, Telegrafo Michele, Fragomeni Simona, Paoli Francesca De, Bogani Giorgio, Gueli Alletti Salvatore, Pedone Anchora Luigi, Della Corte Luigi, Piovano Elisa, Borghese Martina, Taliento Cristina, Raimondo Diego, Raffone Antonio, Casarin Jvan, Perrone Emanuele, Stabile Guglielmo, and Capozzi Vito
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surgery ,ergonomic ,gyne and obstetrics ,operatory room ,survey ,Public aspects of medicine ,RA1-1270 - Abstract
IntroductionSurgical-related injuries are frequent, in fact the reported percentage of musculoskeletal disorders in surgeons is between 47% and 87%. These conditions are caused by long periods of standing, incorrect postures, repeated movements, little rest between operations, the lack of integrated operator rooms, the correct number and arrangement of monitors and the use of non-ergonomic instruments. This survey aims to assess the Italian overview both highlighting how prevalent surgical-related injury is in our surgeons and whether there is an operating room ergonomics education program in Italian surgical specialty schools.MethodsAn anonymous questionnaire was designed through SurveyMonkey© web application. This survey was composed of 3 different sections concerning the general characteristics of the participants, their surgical background and any training performed, and any injuries or ailments related to the surgical activity. The survey was carried out in the period 1th of December 2022 and the 6th of February 2023.ResultsAt the close of our survey, 300 responses were collected. Among the participants, the two most represented specialties were Gynecology and Obstetrics (42.3%) and General Surgery (39.7%) and surgeons were mainly employed in the Northern regions of Italy (54.8%). Analyzing the participants’ background, 61.7% of the respondents had laparoscopic training during their training and only 53.1% had a pelvic trainer during their residency. In accordance with 98.7% of the respondents, during surgery we have the feeling of being in an uncomfortable position that causes discomfort or muscle pain, and regarding the frequency of these discomforts, the majority of our study population experiences these problems monthly (46.2%), while in 29.6% it is experienced weekly, 12.1% annually and finally 12.1% daily. The surgical approach that is most correlated with these disorders is laparoscopy (62.7%) while the one that causes the least discomfort is robotic surgery (1.4%). These discomforts cause 43.9% of our population to take a break or do short exercises to reduce pain during surgery, and the body areas most affected are the back (61.6%), neck (40.6%) and shoulders (37.8%).ConclusionDespite this, our survey allows us to highlight some now-known gaps present in the surgical training program of our schools and the lack of protection toward our surgeons during their long career.
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- 2024
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5. Potential role of SIRT-1 and SIRT-3 as biomarkers for the diagnosis and prognosis of idiopathic pulmonary fibrosis
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Fabio Perrotta, Vito D’Agnano, Domenica Francesca Mariniello, Giuseppe Castaldo, Maria Vitale, Mario Cazzola, Andrea Bianco, and Filippo Scialò
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Idiopathic pulmonary fibrosis ,Sirtuins ,Biomarkers ,Senescence ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a debilitating and progressive lung disease of unknown aetiology, characterized by the relentless deposition of fibrotic tissue. Biomarkers may play a pivotal role as indicators of disease presence, progression, and treatment response. Sirtuins, a family of enzymes with ADP ribosyltransferase or deacetylase activity, have been implicated in several diseases, including pulmonary fibrosis. Methods A cross-sectional, prospective, observational single-center study was conducted to investigate the potential role of serum SIRTs levels as biomarkers in patients with IPF. Demographic, clinical, and functional data and serological samples were collected from 34 patients with IPF followed at the Interstital Lung and Rare Diseases Outpatient Clinic of the Vanvitelli Pneumology Clinic, Monaldi Hospital, Naples, Italy and from 19 age-matched controls. Results Serum SIRT-1 levels were significantly reduced in IPF patients compared to controls (median IPF 667 [435–858] pg/mL versus controls 925 [794–1173] pg/mL; p
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- 2024
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6. Characterisation of clinical response and transcriptional profiling of proliferating CD8 T cells in the blood of cancer patients after PD-1 monotherapy or combination therapy
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Peng Li, Haydn Kissick, Rebecca C Obeng, Tahseen H Nasti, Christiane S Eberhardt, Rafi Ahmed, Zhengjia Chen, Warren J Leonard, Suresh S Ramalingam, Andreas Wieland, Annapaola Mariniello, Jeffrey M Switchenko, Kylee Martens, Daniel Y Chang, Donald McGuire, Candace Daugherty, Yuzi Zhang, Rathi Pillai, and Alice O Kamphorst
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Objective Immune checkpoint inhibitors (ICI) that block the programmed cell death 1 (PD-1) pathway have shown promise with limited benefit. We and others have shown in small patient cohorts that an early proliferative CD8 T-cell response in the blood may be predictive of clinical response. However, these studies lack detailed analyses and comparisons between monotherapy and combination therapies.Methods and analysis We analysed longitudinal blood samples from 103 patients with cancer who received αPD-1 monotherapy or combined with anti-cytotoxic T lymphocyte-associated protein 4 (αCTLA-4) or chemotherapy. Transcriptional analysis of CD8 T cells after the first treatment cycle with effector cells generated following yellow fever virus (YFV-17D) vaccine-induced infection was also compared.Results An early proliferative (Ki-67+) CD8 T-cell response was observed after cycle 1 in 60 patients (58.3%). Patients with early-and-sustained proliferative responses (cycle 1 and beyond) had better clinical responses and survival than patients with an early-but-limited response (p=0.02). The proliferating cells had an effector-like phenotype. The transcriptional profiles of the effector-like CD8 T cells were similar irrespective of treatment type or clinical response but distinct from that of YFV-specific effector CD8 T cells.Conclusions Our data suggest that early proliferative CD8 T-cell response in the blood is predictive, and that an early-and-sustained proliferative response may further identify patients with prolonged survival. The ICI-induced effector-like CD8 T cells are transcriptionally distinct from highly functional YFV-specific cells, suggesting opportunities for improved T-cell effector function with combination therapies for better clinical outcome.
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- 2024
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7. Lung Microbiome as a Treatable Trait in Chronic Respiratory Disorders
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Scialò, Filippo, Vitale, Maria, D’Agnano, Vito, Mariniello, Domenica Francesca, Perrotta, Fabio, Castaldo, Alice, Campbell, Susan F. M., Pastore, Lucio, Cazzola, Mario, and Bianco, Andrea
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- 2023
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8. Quality of life and satisfaction of patients after oncoplastic or traditional breast-conserving surgery using the BREAST-Q (BCT module): a prospective study
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Ghilli, M., Mariniello, M. D., Ferrè, F., Morganti, R., Perre, E., Novaro, R., Colizzi, L., Camilleri, V., Baldetti, G., Rossetti, E., Coletti, L., Scatena, C., Ghilardi, M., Cossu, M. C., and Roncella, M.
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- 2023
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9. Morphological characterization and in vitro digestibility of seven Lathyrus sativus (grass pea) accessions originating from Eurasia, Africa, and Canada
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Lassoued, Siwar, Giosafatto, Concetta Valeria Lucia, Mariniello, Loredana, and Neila, Trifi-Farah
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- 2023
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10. Cell-free biomimetic polyurethane-based scaffold for breast reconstruction following non-malignant lesion resection. A first-in-human study
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Mariniello, Maria Donatella, Ghilli, Matteo, Favati, Benedetta, Gerges, Irini, Colizzi, Livio, Tamplenizza, Margherita, Tocchio, Alessandro, Martello, Federico, Ghilardi, Maria, Cossu, Maria Cristina, Danti, Serena, and Roncella, Manuela
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- 2023
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11. Genomic Profiling for Predictive Treatment Strategies in Fibrotic Interstitial Lung Disease
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Fabio Perrotta, Stefano Sanduzzi Zamparelli, Vito D’Agnano, Antonia Montella, Ramona Fomez, Raffaella Pagliaro, Angela Schiattarella, Mario Cazzola, Andrea Bianco, and Domenica Francesca Mariniello
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pharmacogenomics ,interstitial lung diseases ,idiopathic pulmonary fibrosis ,antifibrotics ,nintedanib ,pirfenidone ,Biology (General) ,QH301-705.5 - Abstract
Idiopathic pulmonary fibrosis (IPF) has traditionally been considered the archetype of progressive fibrotic interstitial lung diseases (f-ILDs), but several other f-ILDs can also manifest a progressive phenotype. Integrating genomic signatures into clinical practice for f-ILD patients may help to identify patients predisposed to a progressive phenotype. In addition to the risk of progressive pulmonary fibrosis, there is a growing body of literature examining how pharmacogenomics influences treatment response, particularly regarding the efficacy and safety profiles of antifibrotic and immunomodulatory agents. In this narrative review, we discuss current studies in IPF and other forms of pulmonary fibrosis, including systemic autoimmune disorders associated ILDs, sarcoidosis and hypersensitivity pneumonitis. We also provide insights into the future direction of research in this complex field.
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- 2024
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12. Topographic Patterns of Intracranial Meningioma Recurrences—Systematic Review with Clinical Implication
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Sergio Corvino, Roberto Altieri, Giuseppe La Rocca, Amedeo Piazza, Giuseppe Corazzelli, Carmela Palmiero, Giuseppe Mariniello, Francesco Maiuri, Andrea Elefante, and Oreste de Divitiis
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intracranial meningiomas ,recurrences ,topographic pattern ,classification ,risk factors ,radiation therapy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: While several risk factors for recurrences have been defined, the topographic pattern of meningioma recurrences after surgical resection has been scarcely investigated. The possibility of theoretically predicting the site of recurrence not only allows us to better understand the pathogenetic bases of the disease and consequently to drive the development of new targeted therapies, but also guides the decision-making process for treatment strategies and tailored follow-ups to decrease/prevent recurrence. Methods: The authors performed a comprehensive and detailed systematic literature review of the EMBASE and MEDLINE electronic online databases regarding the topographic pattern of recurrence after surgical treatment for intracranial meningiomas. Demographics and histopathological, neuroradiological and treatment data, pertinent to the topography of recurrences, as well as time to recurrences, were extracted and analyzed. Results: Four studies, including 164 cases of recurrences according to the inclusion criteria, were identified. All studies consider the possibility of recurrence at the previous dural site; three out of four, which are the most recent, consider 1 cm outside the previous dural margin to be the main limit to distinguish recurrences closer to the previous site from those more distant. Recurrences mainly occur within or close to the surgical bed; higher values of proliferation index are associated with recurrences close to the original site rather than within it. Conclusions: Further studies, including genomic characterization of different patterns of recurrence, will better clarify the main features affecting the topography of recurrences. A comparison between topographic classifications of intracranial meningioma recurrences after surgery and after radiation treatment could provide further interesting information.
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- 2024
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13. Spheno-Orbital Meningiomas: The Rationale behind the Decision-Making Process of Treatment Strategy
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Giuseppe Mariniello, Sergio Corvino, Giuseppe Corazzelli, Oreste de Divitiis, Giancarlo Fusco, Adriana Iuliano, Diego Strianese, Francesco Briganti, and Andrea Elefante
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spheno-orbital meningiomas ,skull base meningiomas ,sphenoid wing ,cranio-orbital tumors ,orbital tumors ,endoscopic transorbital approach ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Surgery stands as the primary treatment for spheno-orbital meningiomas, following a symptoms-oriented approach. We discussed the decision-making process behind surgical strategies through a review of medical records from 80 patients who underwent surgical resection at the University of Naples Federico II. Different surgical approaches were employed based on the tumor’s location relative to the optic nerve’s long axis, categorized into lateral (type I), medial (type II), and diffuse (type III). We examined clinical, neuroradiological, surgical, pathological, and outcome factors. Proptosis emerged as the most frequent symptom (97%), followed by visual impairment (59%) and ocular motility issues (35%). Type I represented 20%, type II 43%, and type III 17%. Growth primarily affected the optic canal (74%), superior orbital fissure (65%), anterior clinoid (60%), and orbital apex (59%). The resection outcomes varied, with Simpson grades I and II achieved in all type I cases, 67.5% of type II, and 18% of type III. Recurrence rates were highest in type II (41.8%) and type III (59%). Improvement was notable in proptosis (68%) and visual function (51%, predominantly type I). Surgery for spheno-orbital meningiomas should be tailored to each patient, considering individual characteristics and tumor features to improve quality of life by addressing primary symptoms like proptosis and visual deficits.
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- 2024
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14. Study Protocol for the Residents’ Mental Health Investigation, a Dynamic Longitudinal Study in Italy (ReMInDIt)
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Marta Caminiti, Michelangelo Mercogliano, Federico Cussotto, Giovanni Leonardo Briganti, Dario Genovese, Walter Priano, Giorgia Maria Ricciotti, Nicole Bonaccorso, Fabiano Grassi, Antonio Antonelli, Gloria Girolametto, Gloria Spatari, Vincenza Gianfredi, Antonella Mariniello, Mariagrazia Marisei, Giuseppa Minutolo, Angela Ancona, Valentina De Nicolò, Nausicaa Berselli, Veronica Gallinoro, Claudia Cosma, Gaia Piunno, Vincenzo Montagna, and Alessandro Catalini
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mental health ,healthcare personnel ,medical residencies ,longitudinal studies ,protocol study ,Medicine - Abstract
Medical residents constitute a vulnerable population susceptible to mental health disorders. In Italy, this was evident during the COVID-19 pandemic, when medical residents served on the front line and provided significant support to healthcare services. Therefore, the working group on “Public Mental Health” of the Medical Residents’ Council of the Italian Society of Hygiene, Preventive Medicine, and Public Health (S.It.I.) designed the “Residents’ mental health investigation, a dynamic longitudinal study in Italy” (ReMInDIt). This longitudinal study aims to assess the mental status of medical residents and to explore potential cause–effect relationships between risk/protective factors (identified among sociodemographic, residency program, and lifestyle characteristics) and mental health outcomes (anxiety and depressive symptoms). Data will be collected from a study population of 3615 residents enrolled in Italian residency programs in public health, occupational medicine, and forensic medicine through an online questionnaire that includes validated tools, requires 10 min for completion, and is disseminated by the residents’ Councils. It will be followed by a follow-up administration after 12 months. The ReMInDIt study will play a significant role in generating evidence crucial for enhancing mental health services and promoting protective factors for the mental well-being of this important segment of healthcare professionals.
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- 2024
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15. Biodegradable Polymeric Micro/Nano-Structures with Intrinsic Antifouling/Antimicrobial Properties:Relevance in Damaged Skin and Other Biomedical Applications
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Milazzo, Mario, Gallone, Giuseppe, Marcello, Elena, Mariniello, Maria Donatella, Bruschini, Luca, Roy, Ipsita, and Danti, Serena
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Physics - Biological Physics ,Physics - Medical Physics - Abstract
Bacterial colonization ofimplanted biomedical devicesis themain cause of healthcare-associated infections, estimated to be 8.8 million per year in Europe. Many infections originate from damaged skin, which lets microorganisms exploit injuries and surgical accesses as passageways to reach the implant site and inner organs. Therefore, an effective treatment of skin damage is highly desirable for the success of many biomaterial-related surgical procedures. Due to gained resistance to antibiotics, new antibacterial treatments are becoming vital to control nosocomial infections arising as surgical and post-surgical complications. Surface coatings can avoid biofouling and bacterial colonization thanks to biomaterial inherent properties (e.g., super hydrophobicity), specifically without using drugs, which may cause bacterial resistance. The focus of this review is to highlight the emerging role of degradable polymeric micro- and nano-structures that show intrinsic antifouling and antimicrobial properties, with a special outlook towards biomedical applications dealing with skin and skin damage. The intrinsic properties owned by the biomaterials encompass three main categories: (1) physical-mechanical, (2) chemical, and (3) electrostatic. Clinical relevance in ear prostheses and breast implants is reported. Collecting and discussing the updated outcomes in this field would help the development of better performing biomaterial-based antimicrobial strategies, which are useful to prevent infections.
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- 2020
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16. Allelic effects on uromodulin aggregates drive autosomal dominant tubulointerstitial kidney disease
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Guglielmo Schiano, Jennifer Lake, Marta Mariniello, Céline Schaeffer, Marianne Harvent, Luca Rampoldi, Eric Olinger, and Olivier Devuyst
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ADTKD‐UMOD ,aggregates ,gain‐of‐function ,kidney fibrosis ,unfolded protein response ,Medicine (General) ,R5-920 ,Genetics ,QH426-470 - Abstract
Abstract Missense mutations in the uromodulin (UMOD) gene cause autosomal dominant tubulointerstitial kidney disease (ADTKD), one of the most common monogenic kidney diseases. The unknown impact of the allelic and gene dosage effects and fate of mutant uromodulin leaves open the gap between postulated gain‐of‐function mutations, end‐organ damage and disease progression in ADTKD. Based on two prevalent missense UMOD mutations with divergent disease progression, we generated UmodC171Y and UmodR186S knock‐in mice that showed strong allelic and gene dosage effects on uromodulin aggregates and activation of ER stress and unfolded protein and immune responses, leading to variable kidney damage. Deletion of the wild‐type Umod allele in heterozygous UmodR186S mice increased the formation of uromodulin aggregates and ER stress. Studies in kidney tubular cells confirmed differences in uromodulin aggregates, with activation of mutation‐specific quality control and clearance mechanisms. Enhancement of autophagy by starvation and mTORC1 inhibition decreased uromodulin aggregates. These studies substantiate the role of toxic aggregates as driving progression of ADTKD‐UMOD, relevant for therapeutic strategies to improve clearance of mutant uromodulin.
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- 2023
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17. Judiciarisation of the mentally ill and/or mentally incapacitated in the Malawi criminal justice system: Gaps and flaws of human rights protection
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Marie Claire Van Hout, Ruth Kaima, Victor Mhango, Stephanie Kewley, and Triestino Mariniello
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Convention on the rights of persons with disabilities ,Malawi ,Criminal justice system ,Prison system ,Mental illness ,Mental incapacity ,Law ,Psychiatry ,RC435-571 - Abstract
Rates (where recorded) of mental illness, intellectual disabilities and co-morbidities are disproportionately high and rising among global prison populations. There is little data on the extent of mental illness and/or mental incapacity in prison populations in the Global South. Criminal justice systems are generally under-resourced, with a lack of adequate forensic monitoring, availability of specialist psychological and psychiatric expertise, and system coordination with mental health treatment and support services.Very little is known with regard to the judiciarisation of the mentally ill and/or mentally incapacitated in African criminal justice systems. In this Commentary we focus on Malawi, as a least developed country in sub-Saharan Africa. We present the international human rights framework pertinent to the judiciarisation of people with disability, the global discourse around disability-neutral doctrines and the contentiousness of the link between mental and legal capacity. We discuss challenges and procedural complexities in the Malawi criminal justice system as it relates to how people with mental illness and/or mental incapacity navigate the process and to what extent their basic human rights are upheld.Mental health legislation and policies to uphold the rights of the mentally ill and/or mentally incapacitated in the criminal justice system are underdeveloped (and under-resourced). There are backlogs in forensic assessments to determine competency to stand trial and criminal responsibility; inadequate availability of forensic beds; and insufficient coverage of community and prison based mental health services. Lengthy detention periods in overcrowded unsafe conditions are common, with little or no access to specialist medical care.We present medico-legal and clinical recommendations for enhanced human rights monitoring and protections cognisant of the various challenges in ensuring the implementation of human rights and of due process in Malawi. We encourage the government to consider formal diversion options via mental health courts and invest in the capacity of forensic specialists and hospitals to support court assessments and community care. Oversight mechanisms preventing human rights abuses of these very vulnerable individuals are crucial in all mental health settings in Malawi, not limited to police custody, remand detention facilities and prisons. Ratification of the Optional Protocol of the Convention against Torture is imperative.
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- 2023
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18. Effectiveness of Autologous Platelet Concentrates in the Sinus Lift Surgery: Findings from Systematic Reviews and Meta-Analyses
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Roberta Gasparro, Alessandro Espedito Di Lauro, Maria Domenica Campana, Nicola Rosiello, Mauro Mariniello, Gilberto Sammartino, and Gaetano Marenzi
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sinus floor augmentation ,bone regeneration ,bone substitute ,dental implantation ,platelet-rich plasma ,platelet-rich fibrin ,Dentistry ,RK1-715 - Abstract
Maxillary sinus augmentation is one of the most predictable procedures for the rehabilitation of the posterior maxilla. The current overview aimed to summarize the findings provided by systematic reviews (SRs) and meta-analyses on the effectiveness of autologous platelet concentrates (APCs) in sinus lift and to assess the methodological quality of the included SRs. Three electronic databases have been explored. SRs and meta-analyses addressing the effectiveness of APCs in sinus lift technique were included. Clinical, radiographic and histomorphometric findings were considered for APCs as solely grafting materials and APCs in combination with biomaterials. Outcomes were implant survival rate (ISR), implant stability (IS), implant failure (IF), postoperative complications, histomorphometric findings, radiographic bone gain, bone volume and bone density. The methodological quality of the included SRs was assessed using the updated version of “A Measurement Tool to Assess Systematic Review” (AMSTAR-2). Thirty SRs were included. The methodological quality of the included reviews ranged from critically low (3 studies) to high (9 studies). The included SRs showed favorable clinical outcomes, short-term new bone formation and no biological complications when APCs were used both as solely graft material or in combination with other biomaterials. However, no significant additional effects in the long-term period were observed. APCs did not add any further positive effects compared to the physiological healing derived by the natural blood clot. The current overview of SRs highlighted the need for high-quality SRs evaluating the role of APCs in sinus lift though network meta-analyses, in order to identify the most powerful material for sinus lift augmentation. The use of APCs improves the healing of soft tissues and the postoperative quality of life in the short-term period. Thus, its application can be recommended.
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- 2024
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19. Multidisciplinary Approach to the Diagnosis of Idiopathic Interstitial Pneumonias: Focus on the Pathologist’s Key Role
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Stefano Lucà, Francesca Pagliuca, Fabio Perrotta, Andrea Ronchi, Domenica Francesca Mariniello, Giovanni Natale, Andrea Bianco, Alfonso Fiorelli, Marina Accardo, and Renato Franco
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interstitial lung disease ,idiopathic interstitial pneumonias ,idiopathic pulmonary fibrosis ,usual interstitial pneumonia ,nonspecific interstitial pneumonia ,organizing pneumonia ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Idiopathic Interstitial Pneumonias (IIPs) are a heterogeneous group of the broader category of Interstitial Lung Diseases (ILDs), pathologically characterized by the distortion of lung parenchyma by interstitial inflammation and/or fibrosis. The American Thoracic Society (ATS)/European Respiratory Society (ERS) international multidisciplinary consensus classification of the IIPs was published in 2002 and then updated in 2013, with the authors emphasizing the need for a multidisciplinary approach to the diagnosis of IIPs. The histological evaluation of IIPs is challenging, and different types of IIPs are classically associated with specific histopathological patterns. However, morphological overlaps can be observed, and the same histopathological features can be seen in totally different clinical settings. Therefore, the pathologist’s aim is to recognize the pathologic–morphologic pattern of disease in this clinical setting, and only after multi-disciplinary evaluation, if there is concordance between clinical and radiological findings, a definitive diagnosis of specific IIP can be established, allowing the optimal clinical–therapeutic management of the patient.
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- 2024
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20. Streptomycetes as Microbial Cell Factories for the Biotechnological Production of Melanin
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Talayeh Kordjazi, Loredana Mariniello, Concetta Valeria Lucia Giosafatto, Raffaele Porta, and Odile Francesca Restaino
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antimicrobial ,antioxidant ,heavy metal chelation ,melanin ,pigment ,Streptomyces ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Melanins are complex, polymeric pigments with interesting properties like UV-light absorbance ability, metal ion chelation capacity, antimicrobial action, redox behaviors, and scavenging properties. Based on these characteristics, melanins might be applied in different industrial fields like food packaging, environmental bioremediation, and bioelectronic fields. The actual melanin manufacturing process is not environmentally friendly as it is based on extraction and purification from cuttlefish. Synthetic melanin is available on the market, but it is more expensive than animal-sourced pigment and it requires long chemical procedures. The biotechnological production of microbial melanin, instead, might be a valid alternative. Streptomycetes synthesize melanins as pigments and as extracellular products. In this review, the melanin biotechnological production processes by different Streptomyces strains have been revised according to papers in the literature. The different fermentation strategies to increase melanin production such as the optimization of growth conditions and medium composition or the use of raw sources as growth substrates are here described. Diverse downstream purification processes are also reported as well as all the different analytical methods used to characterize the melanin produced by Streptomyces strains before its application in different fields.
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- 2024
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21. Targeting Progression in Pulmonary Fibrosis: An Overview of Underlying Mechanisms, Molecular Biomarkers, and Therapeutic Intervention
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Vito D’Agnano, Domenica Francesca Mariniello, Michela Ruotolo, Gianluca Quarcio, Alessandro Moriello, Stefano Conte, Antonio Sorrentino, Stefano Sanduzzi Zamparelli, Andrea Bianco, and Fabio Perrotta
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progressive pulmonary fibrosis ,biomarkers ,antifibrotics ,nintedanib ,pirfenidone ,Science - Abstract
Interstitial lung diseases comprise a heterogenous range of diffuse lung disorders, potentially resulting in pulmonary fibrosis. While idiopathic pulmonary fibrosis has been recognized as the paradigm of a progressive fibrosing interstitial lung disease, other conditions with a progressive fibrosing phenotype characterized by a significant deterioration of the lung function may lead to a burden of significant symptoms, a reduced quality of life, and increased mortality, despite treatment. There is now evidence indicating that some common underlying biological mechanisms can be shared among different chronic fibrosing disorders; therefore, different biomarkers for disease-activity monitoring and prognostic assessment are under evaluation. Thus, understanding the common pathways that induce the progression of pulmonary fibrosis, comprehending the diversity of these diseases, and identifying new molecular markers and potential therapeutic targets remain highly crucial assignments. The purpose of this review is to examine the main pathological mechanisms regulating the progression of fibrosis in interstitial lung diseases and to provide an overview of potential biomarker and therapeutic options for patients with progressive pulmonary fibrosis.
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- 2024
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22. Time trends in health-related quality of life assessment and reporting within publications of oncology randomised phase III trials: a meta-research study
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Raimondo Di Liello, Massimo Di Maio, Francesco Perrone, Fabio Turco, Alessandro Rossi, Piera Gargiulo, Andrea Caglio, Valentina Tuninetti, Eleonora Ghisoni, Laura Marandino, Federica Trastu, Pasquale Lombardi, Annapaola Mariniello, Maria Lucia Reale, Giacomo Aimar, Marco Audisio, Maristella Bungaro, Teresa Gamba, and Chiara Paratore
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Objective To assess time trends in the inclusion of health-related quality of life (QoL) among study endpoints and in the reporting of QoL results in study publications, randomised phase III oncology trials published between 2017 and 2021 were compared with the trials published in the previous 5 years.Methods and analysis All issues published between 2012 and 2021 by 11 major journals were handsearched for primary publications of phase III trials in adult patients with solid tumours. Trials published in 2017–2021 were compared with trials published in 2012–2016 for three endpoints: (1) proportion of publications including QoL among endpoints out of all the eligible publications; (2) proportion of publications presenting QoL results out of those including QoL among endpoints and (3) proportion of publications presenting QoL data out of all the eligible publications.Results 388 publications between 2017 and 2021 were eligible and compared with 446 publications between 2012 and 2016. QoL was included among endpoints in 67.8% of trials in 2017–2021 vs 52.9% in 2012–2016 (univariate OR 1.87, 95% CI 1.41 to 2.48, p
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- 2023
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23. A New Italian Cultural Heritage Data Set: Detecting Fake Reviews With BERT and ELECTRA Leveraging the Sentiment
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Rosario Catelli, Luca Bevilacqua, Nicola Mariniello, Vladimiro Scotto Di Carlo, Massimo Magaldi, Hamido Fujita, Giuseppe De Pietro, and Massimo Esposito
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Italian cultural heritage ,data set ,fake reviews ,sentiment analysis ,deceptive ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
The growth of the online review phenomenon, which has expanded from specialised trade magazines to end users via online platforms, has also increasingly involved the cultural heritage of countries, a source of tourism and growth driver of local economies. Unfortunately, this has been paralleled by the emergence and spread of the phenomenon of fake reviews, against which the scientific world has developed language models capable of distinguishing them from the truthful. The application of such models, often based on deep neural networks with transformer-type architectures, is however limited by the availability of local language data sets for specific domains, useful for both training and verification. The purpose of this article is twofold. Firstly, a new data set was created in the Italian language, generally considered low-resource, relating to the domain of cultural heritage in Italy, by collecting reviews available online, reorganising them in the form of a data set usable by the language models. Secondly, a baseline of results for the detection of misleading reviews was constructed by exploiting two widely used language models, namely BERT and ELECTRA. The performance achieved is interesting, around 95% accuracy and F1 score, using data set splits between training and testing of 80/20 and 90/10. In addition, SHAP was used as a tool to support the explicability of AI models: in this way, it was possible to show the usefulness of sentiment analysis as a support for the recognition of deceptiveness.
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- 2023
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24. Patient-reported outcome and cognitive measures to be used in vascular and brain tumor surgery: proposal for a minimum set
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Schiavolin, Silvia, Mariniello, Arianna, Broggi, Morgan, Abete-Fornara, Giorgia, Bollani, Alessandra, G, Giulio Palmas, Bottini, Gabriella, Querzola, Matteo, Scarpa, Pina, Casarotti, Alessandra, De Michele, Sara, Isella, Valeria, Mauri, Ilaria, Maietti, Alessandra, Miramonti, Valentina, Orru, Maria Immacolata, Pertichetti, Marta, Pini, Elisa, Regazzoni, Rossana, Subacchi, Sara, Ferroli, Paolo, and Leonardi, Matilde
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- 2022
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25. The crosstalk between FGF21 and GH leads to weakened GH receptor signaling and IGF1 expression and is associated with growth failure in very preterm infants
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Jayna N. Mistry, Sanna Silvennoinen, Farasat Zaman, Lars Sävendahl, Katia Mariniello, Charlotte Hall, Sasha R. Howard, Leo Dunkel, Ulla Sankilampi, and Leonardo Guasti
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GH signaling ,GH resistance ,FGF21 ,growth plate ,preterm infants ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
BackgroundFibroblast growth factor 21 (FGF21) is an essential metabolic regulator that adapts to changes in nutritional status. Severe childhood undernutrition induces elevated FGF21 levels, contributing to growth hormone (GH) resistance and subsequent linear growth attenuation potentially through a direct action on chondrocytes.MethodsIn this study, we assessed expression of the components of both GH and FGF21 pathways in rare and unique human growth plates obtained from children. Moreover, we investigated the mechanistic interplay of FGF21 on GH receptor (GHR) signaling in a heterologous system.ResultsChronic FGF21 exposure increased GH-induced GHR turnover and SOCS2 expression, leading to the inhibition of STAT5 phosphorylation and IGF-1 expression. The clinical significance of FGF21 signaling through GH receptors was tested in nutritionally driven growth failure seen in very preterm (VPT) infants right after birth. VPT infants display an immediate linear growth failure after birth followed by growth catch-up. Consistent with the in vitro model data, we show that circulating FGF21 levels were elevated during deflection in linear growth compared to catch-up growth and were inversely correlated with the length velocity and circulating IGF1 levels.ConclusionsThis study further supports a central role of FGF21 in GH resistance and linear growth failure and suggests a direct action on the growth plate.
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- 2023
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26. Biotechnological Production and Characterization of Extracellular Melanin by Streptomyces nashvillensis
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Odile Francesca Restaino, Paola Manini, Talayeh Kordjazi, Maria Laura Alfieri, Massimo Rippa, Loredana Mariniello, and Raffaele Porta
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antioxidant ,melanin ,metal-chelation ,UV-light protection ,Streptomyces nashvillensis DSM 40314 ,Biology (General) ,QH301-705.5 - Abstract
Melanins are pigments employed in food, cosmetic, and textile industries, manufactured by extraction from cuttlefishes. Their biotechnological production by Streptomycetes, instead, has been poorly investigated so far. In this paper, for the first time, the strain Streptomyces nashvillensis DSM 40314 was tested as an extracellular melanin producer by investigating the influence of diverse temperatures (26, 28, and 30 °C) and pH values (6.0 and 7.0) on bacterial growth, melanin production, and on the activity of the secreted tyrosinase, the first enzyme of the pigment biosynthetic pathway. In physiological 96-h shake flask experiments, the optimal growth parameters resulted to be 28 °C and pH 7.0, at which a maximum biomass of 8.4 ± 0.5 gcdw/L, a melanin concentration of 0.74 ± 0.01 g/L (yield on biomass of 0.09 ± 0.01 g/gcdw and productivity of 0.008 ± 0.001 g/L/h), and a final tyrosinase activity of 10.1 ± 0.1 U/mL were reached. The produced pigment was purified from the broth supernatant with a two-step purification process (75.0 ± 2.0% of purity with 65.0 ± 5.0% of recovery) and tested for its chemical, antioxidant, and photoprotective properties. Finally, characterization by UV-visible and FT-IR spectroscopy, elemental analyses, and mono- and bi-dimensional NMR suggested the eumelanin-like nature of the pigment.
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- 2024
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27. Comorbidities in COPD: Current and Future Treatment Challenges
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Domenica Francesca Mariniello, Vito D’Agnano, Donatella Cennamo, Stefano Conte, Gianluca Quarcio, Luca Notizia, Raffaella Pagliaro, Angela Schiattarella, Rosario Salvi, Andrea Bianco, and Fabio Perrotta
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COPD ,comorbidities ,cardiovascular disease ,obstructive sleep apnea ,bronchiectasis ,metabolic syndrome ,Medicine - Abstract
Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition, primarily characterized by the presence of a limited airflow, due to abnormalities of the airways and/or alveoli, that often coexists with other chronic diseases such as lung cancer, cardiovascular diseases, and metabolic disorders. Comorbidities are known to pose a challenge in the assessment and effective management of COPD and are also acknowledged to have an important health and economic burden. Local and systemic inflammation have been proposed as having a potential role in explaining the association between COPD and these comorbidities. Considering that the number of patients with COPD is expected to rise, understanding the mechanisms linking COPD with its comorbidities may help to identify new targets for therapeutic purposes based on multi-dimensional assessments.
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- 2024
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28. Neurological involvement associated with COVID-19 disease: a study on psychosocial factors
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Mariniello, Arianna, Schiavolin, Silvia, Magnani, Francesca, Cristillo, Viviana, Piccinelli, Stefano Cotti, Zoppi, Nicola, Bonzi, Giulio, Sattin, Davide, Silvaggi, Fabiola, Raggi, Alberto, Cacciatore, Martina, Guastafierro, Erika, Toppo, Claudia, Gipponi, Stefano, Libri, Ilenia, Bezzi, Michela, Leonardi, Matilde, Pilotto, Andrea, and Padovani, Alessandro
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- 2022
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29. Preoperative nonmedical predictors of functional impairment after brain tumor surgery
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Schiavolin, Silvia, Mariniello, Arianna, Broggi, Morgan, DiMeco, Francesco, Ferroli, Paolo, and Leonardi, Matilde
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- 2022
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30. Malignant intraventricular meningioma: literature review and case report
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Maiuri, Francesco, Mariniello, Giuseppe, Barbato, Marcello, Corvino, Sergio, Guadagno, Elia, Chiariotti, Lorenzo, and Del Basso De Caro, Marialaura
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- 2022
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31. Psychological Factors Influencing Adherence to NIV in Neuromuscular Patients Dependent on Non Invasive Mechanical Ventilation: Preliminary Results
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Anna Annunziata, Cecilia Calabrese, Francesca Simioli, Antonietta Coppola, Paola Pierucci, Domenica Francesca Mariniello, and Giuseppe Fiorentino
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anxiety ,NIV acceptance ,non-invasive mechanical ventilation ,Medicine - Abstract
Background: Non-invasive ventilation (NIV) is associated with improvement of both morbility and mortality in patients affected by neuromuscular diseases with chronic respiratory failure. Several studies have also shown that long-term NIV positively impacts the patient’s quality of life and perception of disease status. Its effectiveness is likely related to the adherence to NIV. Several factors, patient- and not patient-related, may compromise adherence to NIV, such as physical, behavioral, familiar, and social issues. Few data are currently available on the role of psychological factors in influencing NIV adherence. Materials and methods: In this pilot study, we evaluated the adherence to NIV in a group of 15 adult patients with neuromuscular diseases (Duchenne muscular dystrophy, myotonic dystrophy, and amyotrophic lateral sclerosis) in relation to their grade of depression assessed by the Beck Depression Inventory (BDI) questionnaire. Other data were collected, such as clinical features (age and sex), use of anxiolytic drugs, the presence of a family or professional caregiver, the quality of patient–physician relationship, the beginning of psychological support after BDI screening, and the family acceptance of NIV. NIV adherence was definied as the use of NIV for at least 4 h per night on 70% of nights in a month. Results: The overall rate of NIV adherence was 60%. Based on the BDI questionnaire, patients who were non-adherent to NIV had a higher rate of depression, mainly observed in the oldest patients. The acceptance of NIV by the family and positive physician–patient interaction seem to favor NIV adherence. Conclusion: Depression can interfere with NIV adherence in patients with neuromuscolar diseases.
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- 2023
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32. Exploring the Network between Adipocytokines and Inflammatory Response in SARS-CoV-2 Infection: A Scoping Review
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Ersilia Nigro, Vito D’Agnano, Gianluca Quarcio, Domenica Francesca Mariniello, Andrea Bianco, Aurora Daniele, and Fabio Perrotta
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adipocytokines ,SARS-CoV-2 ,COVID-19 ,adiponectin ,leptin ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Adipose tissue is actually regarded as an endocrine organ, rather than as an organ that merely stores energy. During the COVID-19 pandemic, obesity has undoubtedly emerged as one of the most important risk factors for disease severity and poor outcomes related to SARS-CoV-2 infection. The aberrant production of cytokine-like hormones, called adipokines, may contribute to alterations in metabolism, dysfunction in vascular endothelium and the creation of a state of general chronic inflammation. Moreover, chronic, low-grade inflammation linked to obesity predisposes the host to immunosuppression and excessive cytokine activation. In this respect, understanding the mechanisms that link obesity with the severity of SARS-CoV-2 infection could represent a real game changer in the development of new therapeutic strategies. Our review therefore examines the pathogenic mechanisms of SARS-CoV-2, the implications with visceral adipose tissue and the influences of the adipose tissue and its adipokines on the clinical behavior of COVID-19.
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- 2023
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33. Effects of strict COVID-19 lockdown on patients with obsessive-compulsive disorder compared to a clinical and a nonclinical sample
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Giordano D’Urso, Alfonso Magliacano, Bernardo Dell’Osso, Hekla Lamberti, Adalgisa Luciani, Teresa S. Mariniello, Mattia V. Pomes, Lorenza M. Rifici, Felice Iasevoli, and Andrea de Bartolomeis
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Adjustment disorder ,COVID-19 ,lockdown ,obsessive-compulsive disorder ,Psychiatry ,RC435-571 - Abstract
Abstract Background Symptoms of obsessive-compulsive disorder (OCD) have been reported to increase during the COVID-19 lockdowns because of the hygiene requirements related to the pandemic. Patients with adjustment disorder (AD) may, in turn, represent a vulnerable population for identifiable stressors. In this study, we aimed at assessing potential symptoms changes in OCD patients during the lockdown in comparison with AD patients as well as versus healthy controls (HC). Methods During the COVID-related lockdown, we enrolled 65 patients and 29 HC. Participants were tested with four clinical rating scales (Yale–Brown obsessive-compulsive scale and Brown Assessment of Beliefs Scale for OCD patients; Beck Depression Inventory-II and State–Trait Anxiety Inventory-Y for each group) that had been also administered just before the Italian lockdown. Results Our results showed that during the lockdown: (i) the symptoms of depression and anxiety increased in all groups, but this increase was most pronounced in HC (p
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- 2023
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34. Aerosol delivery through high-flow nasal therapy: Technical issues and clinical benefits
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Cecilia Calabrese, Anna Annunziata, Domenica Francesca Mariniello, Valentino Allocca, Pasquale Imitazione, Rosa Cauteruccio, Francesca Simioli, and Giuseppe Fiorentino
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HFNC ,aerosol–therapeutic ,bronchodilators ,high-flow nasal cannula ,vibrating mesh nebulizer ,jet nebulizer ,Medicine (General) ,R5-920 - Abstract
High-flow nasal cannula (HFNC) therapy is an oxygen delivery method particularly used in patients affected by hypoxemic respiratory failure. In comparison with the conventional “low flow” oxygen delivery systems, it showed several important clinical benefits. The possibility to nebulize drugs via HFNC represents a desirable medical practice because it allows the administration of inhaled drugs, mostly bronchodilators, without the interruption or modification of the concomitant oxygen therapy. HFNC, by itself has shown to exert a small but significant bronchodilator effect and improves muco-ciliary clearance; thus, the nebulization of bronchodilators through the HFNC circuit may potentially increase their pharmacological activity. Several technical issues have been observed which include the type of the nebulizer that should be used, its position within the HFNC circuit, and the optimal gas flow rates to ensure an efficient drug delivery to the lungs both in “quiet” and “distressed” breathing patterns. The aim of this review has been to summarize the scientific evidence coming from “in vitro” studies and to discuss the results of “in vivo” studies performed in adult subjects, mainly affected by obstructive lung diseases. Most studies seem to indicate the vibrating mesh nebulizer as the most efficient type of nebulizer and suggest to place it preferentially upstream from the humidifier chamber. In a quite breathing patterns, the inhaled dose seems to increase with lower flow rates while in a “distressed” breathing pattern, the aerosol delivery is higher when gas flow was set below the patient’s inspiratory flow, with a plateau effect seen when the gas flow reaches approximately 50% of the inspiratory flow. Although several studies have demonstrated that the percentage of the loaded dose nebulized via HFNC reaching the lungs is small, the bronchodilator effect of albuterol seems not to be impaired when compared to the conventional inhaled delivery methods. This is probably attributed to its pharmacological activity. Prospective and well-designed studies in different cohort of patients are needed to standardize and demonstrate the efficacy of the procedure.
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- 2023
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35. Restructuring surgical training after COVID-19 pandemic: A nationwide survey on the Italian scenario on behalf of the Italian polyspecialistic young surgeons society (SPIGC)
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Gaetano Gallo, Eleonora Guaitoli, Fabio Barra, Arcangelo Picciariello, Alessandro Pasculli, Alessandro Coppola, Davide Pertile, Roberto Luca Meniconi, SPIGC Surgical Training Working Group, Federico Berton, Luigi Conti, Giampaolo Formisano, Angelo Iossa, Michele Maruccia, Andrea Mazzari, Luigi Oragano, Francesca Ratti, Matteo Serenari, Alberto Settembrini, Pasquale Sirignano, Domenico Soriero, Carlo Vallicelli, Giuseppe Vizzielli, Ruggero Dimonte, Stefano Cianci, Marco Giovenzana, Geraldo Palmieri, Edoardo Pasqui, Marco Petrillo, Luca Portigliotti, Daniele Sambucci, Giuseppe Sena, Marco Sparavigna, Giordana Bettini, Gianfranco Fanello, Paolo Mendogni, Lorenzo Monteleone, Nicoletta Pia Ardò, Pasquina Tomaiuolo, Giovanni Tomasicchio, Nicola Paradiso, Rigers Dibra, Giuseppe Trigiante, Agnese Dezi, Ludovico Carbone, Sara Negrello, Mattia Di Bartolomeo, Romeo Patini, Alberto Vito Marcuzzo, Alberto Campione, Giovanni Comacchio, Giacomo Murana, Martino Antonio, Mattia Manitto, Giuseppe Galzerano, Carlo Di Marco, Francesco Velluti, Gianmauro Berardi, Andrea Romboli, Federica Perelli, Jacopo Weindelmejer, Domenico Tamburrino, Alessandro Calarco, Luigi Losco, Eleonora Nacchiero, Rossella Elia, Federico Lo Torto, Giovanni Vicenti, Vincenzo Pappalardo, Dafne Pisani, Graziano Palmisano, Debora Brascia, Luigi Troisi, Federica Renzi, Fabio Melandro, Silvia Pecere, Carlo Gazia, Gregorio Di Franco, Gaetano Romano, Alberto Bolletta, Emanuele Botteri, Giovanna Di Meo, Sonia Chiappetta, Ilaria Sgaramella, Francesco Pennestri, Antonella Girardi, Donatella Mariniello, Marco Marcasciano, Michele Telegrafo, Simona Fracomeni, and Francesca De Paoli
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surgical training ,COVID-19 pandemic ,trainee ,training programme ,survey ,Surgery ,RD1-811 - Abstract
IntroductionThe COVID-19 pandemic has led to the disruption of surgical training. Lack of communication, guidelines for managing clinical activity as well as concerns for safety in the workplace appeared to be relevant issues. This study aims to investigate how surgical training has been reorganized in Italy, almost 2 years after the outbreak of COVID-19 pandemic.Materials and methodsA 16-item-electronic anonymous questionnaire was designed through SurveyMonkey© web application. This survey was composed of different sections concerning demographic characteristics and impacts of the second COVID-19 pandemic wave on surgical and research/didactic activities. Changes applied in the training programme and activities carried out were also investigated. The survey was carried out in the period between June and October 2021.ResultsFour hundred and thirty responses were collected, and 399 were considered eligible to be included in the study analysis. Three hundred and thirty-five respondents continued working in Surgical Units, with a significant reduction (less than one surgical session per week) of surgical sessions in 49.6% of them. With concern to didactic and research activities, 140 residents maintained their usual activity, while 116 reported a reduction. A sub-group analysis on resident moved to COVID-19 departments showed a reduction of research activities in 35% of them. During the period considered in this survey, the surgical training program was not substantially modified for most of participants (74.6%).ConclusionOur survey demonstrated that surgical residency programs haven't improved 2 years after the beginning of the pandemic. Further improvements are needed to guarantee completeness of surgical training, even in emergency conditions.
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- 2023
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36. Whole exome sequencing identifies deleterious rare variants in CCDC141 in familial self-limited delayed puberty
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Tansit Saengkaew, Gerard Ruiz-Babot, Alessia David, Alessandra Mancini, Katia Mariniello, Claudia P. Cabrera, Michael R. Barnes, Leo Dunkel, Leonardo Guasti, and Sasha R. Howard
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Medicine ,Genetics ,QH426-470 - Abstract
Abstract Developmental abnormalities of the gonadotropin-releasing hormone (GnRH) neuronal network result in a range of conditions from idiopathic hypogonadotropic hypogonadism to self-limited delayed puberty. We aimed to discover important underlying regulators of self-limited delayed puberty through interrogation of GnRH pathways. Whole exome sequencing (WES) data consisting of 193 individuals, from 100 families with self-limited delayed puberty, was analysed using a virtual panel of genes related to GnRH development and function (n = 12). Five rare predicted deleterious variants in Coiled-Coil Domain Containing 141 (CCDC141) were identified in 21 individuals from 6 families (6% of the tested cohort). Homology modeling predicted all five variants to be deleterious. CCDC141 mutant proteins showed atypical subcellular localization associated with abnormal distribution of acetylated tubulin, and expression of mutants resulted in a significantly delayed cell migration, demonstrated in transfected HEK293 cells. These data identify mutations in CCDC141 as a frequent finding in patients with self-limited delayed puberty. The mis-localization of acetylated tubulin and reduced cell migration seen with mutant CCDC141 suggests a role of the CCDC141-microtubule axis in GnRH neuronal migration, with heterozygous defects potentially impacting the timing of puberty.
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- 2021
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37. Semi-hard buffalo cheese: how cow's milk affects sensory acceptance?
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Bruna Samara dos Santos Rekowsky, Maria Lúcia Guerra Monteiro, Thadeu Mariniello Silva, Carlos Adam Conté-Júnior, and Marion Pereira da Costa
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Buffalo milk ,Coalho cheese ,Consumer expectation ,Dairy product ,Food formulation ,Ripening ,Sensory analysis ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Abstract This study aimed to highlight the effect of cow milk addition (0, 15, 30, and 45%) on Brazilian semi-hard buffalo cheese. Four formulations with different buffalo and cow milk ratios (v/v) were prepared: CC00 (100:00%); CC15 (85:15%); CC30 (70:30%); and CC45 (55:45%). The CC00 presented the highest moisture, fat in dry matter, and salt contents, while CC45 exhibited the highest protein and lowest pH values. CC45 presented the highest flavor, texture, overall acceptability, and purchase intention. Therefore, cow milk addition at 45% is an alternative to improve Brazilian semi-hard buffalo cheese's acceptability and purchase intention and, consequently, a market opportunity for the diversification of buffalo dairy products.
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- 2022
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38. Full immersion in Cultural Heritage environments: A new IDEHA for data managing and displaying
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Luca Bevilacqua, Bruno Fanini, Nicola Mariniello, Augusto Palombini, Vladimiro Scotto Di Carlo, Giuseppe Scardozzi, Antonio Sorgente, and Paolo Vanacore
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Archaeology ,CC1-960 - Abstract
IDEHA (Innovation for Data Elaboration in Heritage Areas), is a PON project coordinated by CNR, aimed to an open platform for real-time aggregation of Cultural Heritage elements (sites, monuments, etc.) data, and their "packaging" in sets of informations for different targets of outlined public. The main tool conceived for displaying data (spread from different sources: news, digital libraries, IoT, etc.) is an immersive viewer capable of displaying 360° images and videos, all multimedia inserts html5-compatible, and multi-language audio-synthesized messages. Such a tool is presented here. It has been planned thanks to the effort of CNR and Engineering, and will be released in order to become a trigger of further initiatives both commercial and free.
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- 2022
39. Moving beyond the politization of same-sex sexuality and leveraging right to health to counter inter-personal sexual violence and HIV in Malawi's prisons
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Marie Claire Van Hout, Ruth Kaima, Victor Mhango, and Triestino Mariniello
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Homosexuality ,Prisons ,Detention ,Human rights ,HIV ,Malawi ,Law ,Psychiatry ,RC435-571 - Abstract
Sexual minority rights in contemporary Africa is a contentious issue, where in some countries, same-sexuality is portrayed by media and politicians as “un-African” and a “white disease” imported from the West. Same-sex sexual activity is criminalised in 31 African countries. Political, legal and religious frameworks exacerbate homophobic attitudes, and related discrimination and hate crimes toward individuals who identify as lesbian, gay, bisexual or transgender (LGBT). We focus here on the rights of people in prison to protection from harm (same-sex sexual violence and sexually transmitted diseases), and who (in many African countries) are ignored in national HIV prevention programming. Prison conditions in Africa are harsh and congested, with inadequate basic needs provisions and this fuels exposure of the vulnerable to sexual violence and engagement in survival sex. HIV rates in prisons are also disproportionately higher than in the community. We present a socio-legal assessment on Malawi where same-sex sexual behaviours are criminalised. The assessment highlights how inmates’ exposure to sexual violence is invisible in political, legal, human rights and public health/HIV agendas in Malawi. Notwithstanding that the Malawi Penal Code and Prison Act prohibits same-sex sexual activity, there are enormous complications with victim disclosure, as claims of rape infer that sodomy has occurred, resulting in victim arrest. We focus here on tackling sexual violence and HIV, and advocate for broad based torture prevention initiatives in prisons to protect the vulnerable from inter-personal sexual violence, and consequent acquisition and onward transmission of HIV. The voices of people in prison in Malawi are regrettably still kept out of societal and public health discourses.
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- 2022
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40. Industrial exoskeletons from bench to field: Human-machine interface and user experience in occupational settings and tasks
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Antonio Baldassarre, Lucrezia Ginevra Lulli, Filippo Cavallo, Laura Fiorini, Antonella Mariniello, Nicola Mucci, and Giulio Arcangeli
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industrial exoskeleton ,occupational medicine ,work-related musculoskeletal disorders ,user experience ,Human-Robot Cooperation ,ergonomics ,Public aspects of medicine ,RA1-1270 - Abstract
ObjectiveWork-related musculoskeletal disorders (WRMSDs) are considered nowadays the most serious issue in the Occupational Health and Safety field and industrial exoskeletons appear to be a new approach to addressing this medical burden. A systematic review has been carried out to analyze the real-life data of the application of exoskeletons in work settings considering the subjective responses of workers.MethodsThe review was registered on PROSPERO. The literature search and its report have been performed following the PRISMA guidelines. A comprehensive literature search was performed in PubMed, EMBASE, Web of Science, and Scopus.ResultsTwenty-four original studies were included in the literature review; 42% of the papers retrieved included automobilist industry workers, 17% of the studies evaluated the use of exoskeletons in logistic facilities, and 17% of articles involved healthcare. The remaining six papers recruited farmers, plasterers, wasting collectors, construction workers, and other workmen. All the papers selected tested the use of passive exoskeletons, supporting upper arms or back. Usability, perceived comfort, perceived exertion and fatigue, acceptability and intention to use, occupational safety and health, and job performance and productivity were the main topic analyzed.ConclusionExoskeletons are not a fix-all technology, neither for workers nor for job tasks; they tend to show more of their potential in static activities, while in dynamic tasks, they can obstacle regular job performance. Comfort and easiness of use are the key factors influencing the user's experience. More research is needed to determine the most effective and safe ways to implement exoskeleton use in occupational settings.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=275728, identifier CRD42021275728.
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- 2022
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41. Regular football training down-regulates miR-1303 muscle expression in veterans
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Mancini, A., Vitucci, D., Orlandella, F. M., Terracciano, A., Mariniello, R. M., Imperlini, E., Grazioli, E., Orrù, S., Krustrup, P., Salvatore, G., and Buono, P.
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- 2021
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42. Trehalose/sodium hyaluronate eye drops in post-cataract ocular surface disorders
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Cagini, Carlo, Torroni, Giovanni, Mariniello, Marco, Di Lascio, Giampiero, Martone, Gianluca, and Balestrazzi, Angelo
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- 2021
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43. Solitary fibrous tumor of the middle cranial fossa: Literature review and case report
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Francesco Maiuri, Giuseppe Mariniello, Sergio Corvino, Vincenzo Meglio, Raduan Ahmed Franca, and Marialaura Del Basso De Caro
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Solitary fibrous tumor ,Hemangiopericytoma ,Middle cranial fossa ,Petrous bone ,Hypoglossal-facial nerve anastomosis ,Surgery ,RD1-811 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Solitary fibrous tumors (SFTs) exceptionally occur at the middle cranial fossa. A midline search from January 1997 up to June 2021 selected 16 articles for a total of 19 patients, where the tumor attachment was completely or largely (>75%) at the middle cranial fossa. The unique personal case concerns a 35 years old woman complaining of left hypoacusia and moderate left facial paresis. A high grade SFT of the left middle fossa was resected, with no recurrence 8 years after surgery and irradiation. The 20 patients of the review, including ours, are 11 men and 9 women with a median age of 47 years. The location was mainly intradural (47%) or extra-intradural (42%); the invasion of the petrous bone was evidenced in a half of the patients. Symptoms of involvement of the Vth, VIIth and VIIIth cranial nerve were more frequent (3/4 of the cases). Variable T2 signal, lobulated margins and inhomogeneous enhancement were the most frequent MRI features. Histologically most tumors (70%) were WHO grade III and 23% grade I. A gross total resection was possible in 55% of the cases. The recurrence rate is significant (23,5%). Older patient age (>50 years), large tumor size, incomplete resection and high WHO grade histology are significant prognostic factors for recurrence. However, the outcome is sometimes unpredictable. Thus, a follow-up by serial MRI studies is strongly advisable.
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- 2022
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44. Effects on Right Ventricular Function One Year after COVID-19-Related Pulmonary Embolism
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Federica Ilardi, Mario Crisci, Cecilia Calabrese, Anna Scognamiglio, Fortunato Arenga, Rachele Manzo, Domenica F. Mariniello, Valentino Allocca, Anna Annunziata, Antonello D’Andrea, Raffaele Merenda, Vittorio Monda, Giovanni Esposito, and Giuseppe Fiorentino
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COVID-19 ,pulmonary embolism ,right-ventricle global longitudinal strain ,right-ventricle free wall longitudinal strain ,right-ventricle dysfunction ,Medicine - Abstract
The aim of this study was to investigate the presence of subclinical cardiac dysfunction in recovered coronavirus disease 2019 (COVID-19) patients, who were stratified according to a previous diagnosis of pulmonary embolism (PE) as a complication of COVID-19 pneumonia. Out of 68 patients with SARS-CoV-2 pneumonia followed up for one year, 44 patients (mean age 58.4 ± 13.3, 70% males) without known cardiopulmonary disease were divided in two groups (PE+ and PE−, each comprising 22 patients) and underwent clinical and transthoracic echocardiographic examination, including right-ventricle global longitudinal strain (RV-GLS), and RV free wall longitudinal strain (RV-FWLS). While no significant differences were found in the left- or right-heart chambers’ dimensions between the two study groups, the PE+ patients showed a significant reduction in RV-GLS (−16.4 ± 2.9 vs. −21.6 ± 4.3%, p < 0.001) and RV-FWLS (−18.9 ± 4 vs. −24.6 ± 5.12%, p < 0.001) values compared to the PE- patients. According to the ROC-curve analysis, RV-FWLS < 21% was the best cut-off with which to predict PE diagnosis in patients after SARS-CoV-2 pneumonia (sensitivity 74%, specificity 89%, area under the curve = 0.819, p < 0.001). According to the multivariate logistic regression model, RV-FWLS < 21% was independently associated with PE (HR 34.96, 95% CI:3.24–377.09, p = 0.003) and obesity (HR 10.34, 95% CI:1.05–101.68, p = 0.045). In conclusion, in recovered COVID-19 patients with a history of PE+, there is a persistence of subclinical RV dysfunction one year after the acute phase of the disease, detectable by a significant impairment in RV-GLS and RV-FWLS. A reduction in RV-FWLS of lower than 21% is independently associated with COVID-related PE.
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- 2023
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45. Minimally Invasive Harvesting Technique for Costal Cartilage Graft: Donor Site, Morbidity and Aesthetic Outcomes
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Umberto Committeri, Antonio Arena, Emanuele Carraturo, Simona Barone, Giovanni Salzano, Domenico Mariniello, Giacomo De Riu, Luigi Angelo Vaira, Francesco Giovacchini, Luigi Califano, and Pasquale Piombino
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cartilage graft ,costal cartilage ,rib cartilage ,nasal reconstruction ,Vancouver Scar Scale ,nose ,Medicine - Abstract
Cartilage grafts are well-known as being reliable in reconstructive surgery for craniofacial pathologies. The aim of this study is to describe a new technique which requires an incision smaller than 1.5 cm but is still effective for harvesting cartilage graft. Thirty-six patients who underwent costal cartilage harvesting for septorhinoplasty have been included in this study, admitted from January 2018 to December 2021. Out of 36 patients, 34 have not reported any major complications, and two cases were followed up for pneumothorax. There were no infections and no chest wall deformities. All patients reported minimal pain at the donor site. The Vancouver Scar Scale was used to evaluate the entity of the postoperative scarring phenomena. This scale total ranges from 0 (representing normal skin) to a maximum score of 13 (representing worst scar imaginable). The results were 1.53 SD ± 0.64 (on average) 1 week after the surgical procedure and 1.28 SD ± 0.45 (on average) at the 6 months follow-up. This minimally invasive method provided a valid and effective surgical technique for cartilage graft. Despite the limitations of the case series, it seems that this procedure might be comparable to other and well-established traditional procedures and could be even preferred when the minimal invasiveness is mandatory.
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- 2023
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46. Adiponectin and leptin exert antagonizing effects on proliferation and motility of papillary thyroid cancer cell lines
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Nigro, Ersilia, Orlandella, Francesca Maria, Polito, Rita, Mariniello, Raffaela Mariarosaria, Monaco, Maria Ludovica, Mallardo, Marta, De Stefano, Anna Elisa, Iervolino, Paola Lucia Chiara, Salvatore, Giuliana, and Daniele, Aurora
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- 2021
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47. Evolving epidemiology of HIV/AIDS in Campania region, 2011–2018: Is HIV/AIDS population in Campania different?
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Francesco Maria Fusco, Nadia Sangiovanni, Silvia Mascolo, Maria Aurora Carleo, Massimo Sardo, Rosaria Viglietti, Giovanni Parrella, Orsola Tambaro, Valentina Iodice, Giusy Di Flumeri, Anna Menna, Assunta Galano, Anna Laudiero, Antonietta Mariniello, Milena De Cenzo, Elio Manzillo, Vincenzo Esposito, Antonio Chirianni, and Vincenzo Sangiovanni
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Medicine (General) ,R5-920 - Abstract
Objectives: Data on HIV/AIDS cases in Italy are collected using a standardised form. Regional epidemiology may vary. We described the epidemiological and clinical characteristics of newly diagnosed persons with HIV in the ‘Cotugno’ hospital in Naples during 2011–2018 and compared them with national data to identify similarities and differences. Methods: Data source for the Campania region is the data collection forms sent to the national surveillance system. The data source for the national data is from the periodic annual bulletins on HIV/AIDS published by the National Institute of Health. Results: In all, 1149 persons with HIV were diagnosed in ‘Cotugno’ (69.7% of those diagnosed in Campania). Persons with HIV in Campania showed many similarities with the Italian population: men were in the majority in both groups (about 75%), foreign origin was about 30%, heterosexuals were the most represented risk group, followed by men who have sex with men and injecting drug use in both samples. Some notable differences are also present. Among the risk factors for HIV acquisition, injecting drug use is significantly more common in Campania. Among the reasons for testing, significant differences are evident for almost all reasons, with screening activities (testing for concurrent diseases, for diagnosis of sexually transmitted diseases, screening in hospital during maternity care and screening in drug-addition services or prisons) being more common at the national level. The Campania population has a more severe disease pattern, with a significantly higher proportion of patients diagnosed with less than 200 CD4 cells/µL and AIDS. For each variable, we compared trends in the Campania region and in Italy using Spearman’s correlation coefficient. Almost all trends show a weak correlation. Conclusion: In conclusion, the prevalence of injecting drug use is still consistent, and requires specific campaigns. The reasons for testing are different: screening activities work less in Campania than in Italy. This untimely approach contributes to a more severe clinical picture in Campania.
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- 2022
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48. Depression and Anxiety Symptoms 'Among the Waves' of the COVID-19 Pandemic in Obsessive Compulsive Disorder and Adjustment Disorder Patients
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Giordano D’Urso, Mattia Vittorio Pomes, Alfonso Magliacano, Carla Iuliano, Hekla Lamberti, Marco Manzo, Teresa Sissy Mariniello, Felice Iasevoli, and Andrea de Bartolomeis
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COVID-19 ,obsessive compulsive disorder ,adjustment disorder ,depression ,anxiety ,Medicine - Abstract
The COVID-19 pandemic and the associated restrictions caused great psychological suffering to the general population and psychiatric patients. We aimed to explore the course of depression and anxiety symptoms in obsessive compulsive disorder (OCD) patients, adjustment disorder (AD) patients, and participants without psychiatric disorders (control group, CG) across the different phases of the pandemic: the first lockdown, a temporary interruption of restrictions, and the second lockdown. Out of the 158 patients screened, we enrolled 46 OCD and 19 AD patients as well as 29 CG participants. The Beck Depression Inventory-II and the State-Trait Anxiety Inventory-Y were administered to all participants at each time point. The results showed different symptom severities among the groups throughout the whole study, with OCD patients always scoring higher than AD patients and the CG, and the AD patients always scoring higher than the CG. The symptom course within each group was different. OCD patients’ symptoms sharply worsened during the first lockdown and then remained stable irrespective of the subsequent pandemic phases. In the AD and CG groups, symptoms waxed and waned following the fluctuations of the restriction provisions, with a complete return to the baseline when the restrictions were stopped only in the CG. These findings suggest that the influence of the pandemic and of the associated restrictions on depression and anxiety manifestations may vary depending on the particular pre-existing mental health status.
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- 2023
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49. Sustainable Exploitation of Posidonia oceanica Sea Balls (Egagropili): A Review
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Odile Francesca Restaino, Concetta Valeria L. Giosafatto, Seyedeh Fatemeh Mirpoor, Marcella Cammarota, Sondos Hejazi, Loredana Mariniello, Chiara Schiraldi, and Raffaele Porta
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cellulose ,egagropili ,holocellulose ,lignin ,marine waste ,Posidonia oceanica ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Posidonia oceanica (L.) Delile is the main seagrass plant in the Mediterranean basin that forms huge underwater meadows. Its leaves, when decomposed, are transported to the coasts, where they create huge banquettes that protect the beaches from sea erosion. Its roots and rhizome fragments, instead, aggregate into fibrous sea balls, called egagropili, that are shaped and accumulated by the waves along the shoreline. Their presence on the beach is generally disliked by tourists, and, thus, local communities commonly treat them as waste to remove and discard. Posidonia oceanica egagropili might represent a vegetable lignocellulose biomass to be valorized as a renewable substrate to produce added value molecules in biotechnological processes, as bio-absorbents in environmental decontamination, to prepare new bioplastics and biocomposites, or as insulating and reinforcement materials for construction and building. In this review, the structural characteristics, and the biological role of Posidonia oceanica egagropili are described, as well as their applications in different fields as reported in scientific papers published in recent years.
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- 2023
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50. A Computational Approach in the Diagnostic Process of COVID-19: The Missing Link between the Laboratory and Emergency Department
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Luisa Lanzilao, Antonella Mariniello, Bianca Polenzani, Alessandra Aldinucci, Peiman Nazerian, Alessio Prota, Stefano Grifoni, Barbara Tonietti, Chiara Neri, Livia Turco, Alessandra Fanelli, Amedeo Amedei, and Elena Stanghellini
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automated classifiers ,covid-19 ,diagnosis ,laboratory medicine ,machine learning ,physicians' gestalt ,Biochemistry ,QD415-436 ,Biology (General) ,QH301-705.5 - Abstract
Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic and so it is crucial the right evaluation of viral infection. According to the Centers for Disease Control and Prevention (CDC), the Real-Time Reverse Transcription PCR (RT-PCR) in respiratory samples is the gold standard for confirming the disease. However, it has practical limitations as time-consuming procedures and a high rate of false-negative results. We aim to assess the accuracy of COVID-19 classifiers based on Arificial Intelligence (AI) and statistical classification methods adapted on blood tests and other information routinely collected at the Emergency Departments (EDs). Methods: Patients admitted to the ED of Careggi Hospital from April 7th–30th 2020 with pre-specified features of suspected COVID-19 were enrolled. Physicians prospectively dichotomized them as COVID-19 likely/unlikely case, based on clinical features and bedside imaging support. Considering the limits of each method to identify a case of COVID-19, further evaluation was performed after an independent clinical review of 30-day follow-up data. Using this as a gold standard, several classifiers were implemented: Logistic Regression (LR), Quadratic Discriminant Analysis (QDA), Random Forest (RF), Support Vector Machine (SVM), Neural Networks (NN), K-nearest neighbor (K-NN), Naive Bayes (NB). Results: Most of the classifiers show a ROC >0.80 on both internal and external validation samples but the best results are obtained applying RF, LR and NN. The performance from the external validation sustains the proof of concept to use such mathematical models fast, robust and efficient for a first identification of COVID-19 positive patients. These tools may constitute both a bedside support while waiting for RT-PCR results, and a tool to point to a deeper investigation, by identifying which patients are more likely to develop into positive cases within 7 days. Conclusions: Considering the obtained results and with a rapidly changing virus, we believe that data processing automated procedures may provide a valid support to the physicians facing the decision to classify a patient as a COVID-19 case or not.
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- 2023
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