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273 results on '"Pötter-Nerger, Monika"'

5. The comorbidity and co-medication profile of patients with progressive supranuclear palsy

Author

Greten, Stephan, Wegner, Florian, Jensen, Ida, Krey, Lea, Rogozinski, Sophia, Fehring, Meret, Heine, Johanne, Doll-Lee, Johanna, Pötter-Nerger, Monika, Zeitzschel, Molly, Hagena, Keno, Pedrosa, David J., Eggers, Carsten, Bürk, Katrin, Trenkwalder, Claudia, Claus, Inga, Warnecke, Tobias, Süß, Patrick, Winkler, Jürgen, Gruber, Doreen, Gandor, Florin, Berg, Daniela, Paschen, Steffen, Classen, Joseph, Pinkhardt, Elmar H., Kassubek, Jan, Jost, Wolfgang H., Tönges, Lars, Kühn, Andrea A., Schwarz, Johannes, Peters, Oliver, Dashti, Eman, Priller, Josef, Spruth, Eike J., Krause, Patricia, Spottke, Annika, Schneider, Anja, Beyle, Aline, Kimmich, Okka, Donix, Markus, Haussmann, Robert, Brandt, Moritz, Dinter, Elisabeth, Wiltfang, Jens, Schott, Björn H., Zerr, Inga, Bähr, Mathias, Buerger, Katharina, Janowitz, Daniel, Perneczky, Robert, Rauchmann, Boris-Stephan, Weidinger, Endy, Levin, Johannes, Katzdobler, Sabrina, Düzel, Emrah, Glanz, Wenzel, Teipel, Stefan, Kilimann, Ingo, Prudlo, Johannes, Gasser, Thomas, Brockmann, Kathrin, Hoffmann, Daniel C., Klockgether, Thomas, Krause, Olaf, Heck, Johannes, Höglinger, Günter U., and Klietz, Martin

Published
2024
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8. Phase-Dependent Suppression of Beta Oscillations in Parkinson's Disease Patients

Author

Holt, Abbey B, Kormann, Eszter, Gulberti, Alessandro, Pötter-Nerger, Monika, McNamara, Colin G, Cagnan, Hayriye, Baaske, Magdalena K, Little, Simon, Köppen, Johannes A, Buhmann, Carsten, Westphal, Manfred, Gerloff, Christian, Engel, Andreas K, Brown, Peter, Hamel, Wolfgang, Moll, Christian KE, and Sharott, Andrew

Subjects
Clinical Research, Parkinson's Disease, Brain Disorders, Neurosciences, Neurodegenerative, Aging, Aetiology, 2.1 Biological and endogenous factors, Underpinning research, 1.1 Normal biological development and functioning, Neurological, Aged, Beta Rhythm, Cerebral Cortex, Deep Brain Stimulation, Electric Stimulation, Electroencephalography, Female, Humans, Male, Middle Aged, Neurons, Neurosurgical Procedures, Parkinson Disease, Subthalamic Nucleus, beta oscillations, clinical neurophysiology, deep brain stimulation, Parkinson's disease, subthalamic nucleus, synchrony, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract

Synchronized oscillations within and between brain areas facilitate normal processing, but are often amplified in disease. A prominent example is the abnormally sustained beta-frequency (∼20 Hz) oscillations recorded from the cortex and subthalamic nucleus of Parkinson's disease patients. Computational modeling suggests that the amplitude of such oscillations could be modulated by applying stimulation at a specific phase. Such a strategy would allow selective targeting of the oscillation, with relatively little effect on other activity parameters. Here, activity was recorded from 10 awake, parkinsonian patients (6 male, 4 female human subjects) undergoing functional neurosurgery. We demonstrate that stimulation arriving on a particular patient-specific phase of the beta oscillation over consecutive cycles could suppress the amplitude of this pathophysiological activity by up to 40%, while amplification effects were relatively weak. Suppressive effects were accompanied by a reduction in the rhythmic output of subthalamic nucleus (STN) neurons and synchronization with the mesial cortex. While stimulation could alter the spiking pattern of STN neurons, there was no net effect on firing rate, suggesting that reduced beta synchrony was a result of alterations to the relative timing of spiking activity, rather than an overall change in excitability. Together, these results identify a novel intrinsic property of cortico-basal ganglia synchrony that suggests the phase of ongoing neural oscillations could be a viable and effective control signal for the treatment of Parkinson's disease. This work has potential implications for other brain diseases with exaggerated neuronal synchronization and for probing the function of rhythmic activity in the healthy brain.SIGNIFICANCE STATEMENT In Parkinson's disease (PD), movement impairment is correlated with exaggerated beta frequency oscillations in the cerebral cortex and subthalamic nucleus (STN). Using a novel method of stimulation in PD patients undergoing neurosurgery, we demonstrate that STN beta oscillations can be suppressed when consecutive electrical pulses arrive at a specific phase of the oscillation. This effect is likely because of interrupting the timing of neuronal activity rather than excitability, as stimulation altered the firing pattern of STN spiking without changing overall rate. These findings show the potential of oscillation phase as an input for "closed-loop" stimulation, which could provide a valuable neuromodulation strategy for the treatment of brain disorders and for elucidating the role of neuronal oscillations in the healthy brain.

Published
2019

9. Directional Deep Brain Stimulation for Parkinson's Disease: Results of an International Crossover Study With Randomized, Double-Blind Primary Endpoint

Author

Schnitzler, Alfons, Vesper, Jan, Mir, Pablo, Verhagen, Leonardo, Tomcyz, Nestor, Hartmann, Christian J., Groppa, Sergiu, Alvarez, Ramiro, Pilitsis, Julie, Pötter-Nerger, Monika, Groiss, Stefan Jun, Brodsky, Matthew A., Verhagen, Leonard, Evans, Andrew, Blazquez, Marta, Nagel, Sean, Pilitsis, Julie G., Tse, Winona, Almeida, Leonardo, Tomycz, Nestor, Jimenez-Shahed, Joohi, Libionka, Witold, Carrillo, Fatima, Glaser, Martin, Defresne, Florence, Karst, Edward, and Cheeran, Binith

Published
2022
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16. Proceedings of the 11th Annual Deep Brain Stimulation Think Tank: pushing the forefront of neuromodulation with functional network mapping, biomarkers for adaptive DBS, bioethical dilemmas, AI-guided neuromodulation, and translational advancements

Author

Johnson, Kara A., primary, Dosenbach, Nico U. F., additional, Gordon, Evan M., additional, Welle, Cristin G., additional, Wilkins, Kevin B., additional, Bronte-Stewart, Helen M., additional, Voon, Valerie, additional, Morishita, Takashi, additional, Sakai, Yuki, additional, Merner, Amanda R., additional, Lázaro-Muñoz, Gabriel, additional, Williamson, Theresa, additional, Horn, Andreas, additional, Gilron, Ro'ee, additional, O'Keeffe, Jonathan, additional, Gittis, Aryn H., additional, Neumann, Wolf-Julian, additional, Little, Simon, additional, Provenza, Nicole R., additional, Sheth, Sameer A., additional, Fasano, Alfonso, additional, Holt-Becker, Abbey B., additional, Raike, Robert S., additional, Moore, Lisa, additional, Pathak, Yagna J., additional, Greene, David, additional, Marceglia, Sara, additional, Krinke, Lothar, additional, Tan, Huiling, additional, Bergman, Hagai, additional, Pötter-Nerger, Monika, additional, Sun, Bomin, additional, Cabrera, Laura Y., additional, McIntyre, Cameron C., additional, Harel, Noam, additional, Mayberg, Helen S., additional, Krystal, Andrew D., additional, Pouratian, Nader, additional, Starr, Philip A., additional, Foote, Kelly D., additional, Okun, Michael S., additional, and Wong, Joshua K., additional

Published
2024
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23. Continuous, Learned Imputation of Missing Values in Parkinson's Disease.

Author

GUNDLER, Christopher and PÖTTER-NERGER, Monika

Abstract

Parkinson's disease management requires accurate clinical scores but suffers from missing data. Leveraging self-supervised learning, we demonstrate superior generalization capabilities across populations compared to other wellestablished imputation techniques (MIWAE, MissForest, MICE). With the ability to employ the method already during the data collection and not afterward, the technology allows more robust data collection in clinical reality. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Nationwide Retrospective Analysis of Combinations of Advanced Therapies in Patients With Parkinson Disease

Author

Pürner, Dominik, primary, Hormozi, Mohammad, additional, Weiß, Daniel, additional, Barbe, Michael T., additional, Jergas, Hannah, additional, Prell, Tino, additional, Gülke, Eileen, additional, Pötter-Nerger, Monika, additional, Falkenburger, Björn, additional, Klingelhöfer, Lisa, additional, Gutsmiedl, Pia K., additional, Haslinger, Bernhard, additional, Jochim, Angela M., additional, Wolff, Andreas, additional, Schröter, Nils, additional, Rijntjes, Michel, additional, van Riesen, Christoph, additional, Scheller, Ute, additional, Wolz, Martin, additional, Amouzandeh, Ali, additional, Ebersbach, Georg, additional, Gruber, Doreen, additional, Kohl, Zacharias, additional, Maetzler, Walter, additional, Paschen, Steffen, additional, Pérez-González, Pablo, additional, Rozanski, Verena, additional, Schwarz, Johannes, additional, Südmeyer, Martin, additional, Torka, Elisabeth, additional, Wesbuer, Simone, additional, Bornmann, Sarah, additional, Flöel, Agnes, additional, Ip, Chi Wang, additional, Krause, Patricia, additional, Kühn, Andrea A., additional, Csoti, Ilona, additional, Herting, Birgit, additional, van de Loo, Simone, additional, Basheer, Aniz Ahammed, additional, Liszka, Robert, additional, Jost, Wolfgang H., additional, Koschel, Jiri, additional, Haller, Bernhard, additional, and Lingor, Paul, additional

Published
2023
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25. The comorbidity and co-medication profile of patients with progressive supranuclear palsy

Author

Greten, Stephan, primary, Wegner, Florian, additional, Jensen, Ida, additional, Krey, Lea, additional, Rogozinski, Sophia, additional, Fehring, Meret, additional, Heine, Johanne, additional, Doll-Lee, Johanna, additional, Pötter-Nerger, Monika, additional, Zeitzschel, Molly, additional, Hagena, Keno, additional, Pedrosa, David J., additional, Eggers, Carsten, additional, Bürk, Katrin, additional, Trenkwalder, Claudia, additional, Claus, Inga, additional, Warnecke, Tobias, additional, Süß, Patrick, additional, Winkler, Jürgen, additional, Gruber, Doreen, additional, Gandor, Florin, additional, Berg, Daniela, additional, Paschen, Steffen, additional, Classen, Joseph, additional, Pinkhardt, Elmar H., additional, Kassubek, Jan, additional, Jost, Wolfgang H., additional, Tönges, Lars, additional, Kühn, Andrea A., additional, Schwarz, Johannes, additional, Peters, Oliver, additional, Dashti, Eman, additional, Priller, Josef, additional, Spruth, Eike J., additional, Krause, Patricia, additional, Spottke, Annika, additional, Schneider, Anja, additional, Beyle, Aline, additional, Kimmich, Okka, additional, Donix, Markus, additional, Haussmann, Robert, additional, Brandt, Moritz, additional, Dinter, Elisabeth, additional, Wiltfang, Jens, additional, Schott, Björn H., additional, Zerr, Inga, additional, Bähr, Mathias, additional, Buerger, Katharina, additional, Janowitz, Daniel, additional, Perneczky, Robert, additional, Rauchmann, Boris-Stephan, additional, Weidinger, Endy, additional, Levin, Johannes, additional, Katzdobler, Sabrina, additional, Düzel, Emrah, additional, Glanz, Wenzel, additional, Teipel, Stefan, additional, Kilimann, Ingo, additional, Prudlo, Johannes, additional, Gasser, Thomas, additional, Brockmann, Kathrin, additional, Hoffmann, Daniel C., additional, Klockgether, Thomas, additional, Krause, Olaf, additional, Heck, Johannes, additional, Höglinger, Günter U., additional, and Klietz, Martin, additional

Published
2023
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30. Subthalamic and nigral neurons are differentially modulated during parkinsonian gait

Author

Gulberti, Alessandro, primary, Wagner, Jonas R, additional, Horn, Martin A, additional, Reuss, Jacob H, additional, Heise, Miriam, additional, Koeppen, Johannes A, additional, Pinnschmidt, Hans O, additional, Westphal, Manfred, additional, Engel, Andreas K, additional, Gerloff, Christian, additional, Sharott, Andrew, additional, Hamel, Wolfgang, additional, Moll, Christian K E, additional, and Pötter-Nerger, Monika, additional

Published
2023
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31. Effects of deep brain stimulation on driving in Parkinson’s disease - a prospective controlled study

Author

Buhmann, Carsten, primary, Fründt, Odette, additional, Mainka, Tina, additional, Vettorazzi, Eik, additional, Baspinar, Ela, additional, Schwarz, Cindy, additional, Südmeyer, Martin, additional, Gerloff, Christian, additional, Zangemeister, Wolfgang, additional, Pötter-Nerger, Monika, additional, Hidding, Ute, additional, Hamel, Wolfgang, additional, and Moll, Christian, additional

Published
2022
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35. Structural Connectivity of Subthalamic Nucleus Stimulation for Improving Freezing of Gait

Author

Strelow, Joshua N., primary, Baldermann, Juan C., additional, Dembek, Till A., additional, Jergas, Hannah, additional, Petry-Schmelzer, Jan N., additional, Schott, Frederik, additional, Dafsari, Haidar S., additional, Moll, Christian K.E., additional, Hamel, Wolfgang, additional, Gulberti, Alessandro, additional, Visser-Vandewalle, Veerle, additional, Fink, Gereon R., additional, Pötter-Nerger, Monika, additional, and Barbe, Michael T., additional

Published
2022
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36. Comparison of Montreal cognitive assessment and Mattis dementia rating scale in the preoperative evaluation of subthalamic stimulation in Parkinson’s disease

Author

Gülke, Eileen, primary, Alsalem, Mohammad, additional, Kirsten, Maja, additional, Vettorazzi, Eik, additional, Choe, Chi-un, additional, Hidding, Ute, additional, Zittel-Dirks, Simone, additional, Buhmann, Carsten, additional, Schaper, Miriam, additional, Gulberti, Alessandro, additional, Moll, Christian K. E., additional, Hamel, Wolfgang, additional, Koeppen, Johannes, additional, Gerloff, Christian, additional, and Pötter-Nerger, Monika, additional

Published
2022
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44. Dysphagia screening in Parkinson's Disease

Author

Frank, Ulrike (Dr. phil.), Radtke, Julia, Nienstedt, Julie Cläre, Pötter-Nerger, Monika, Schönwald, Beate, Buhmann, Carsten, Gerloff, Christian, Niessen, Almut, Flügel, Till, Koseki, Jana-Christiane, and Pflug, Christina

Subjects
Department Linguistik, ddc:410
Abstract

Background Simple water-swallowing screening tools are not predictive of aspiration and dysphagia in patients with Parkinson's Disease (PD). We investigated the diagnostic accuracy of a multi-texture screening tool, the Gugging Swallowing Screen (GUSS) to identify aspiration and dysphagia/penetration in PD patients compared to flexible endoscopic evaluation of swallowing (FEES). Methods Swallowing function was evaluated in 51 PD participants in clinical 'on-medication' state with the GUSS and a FEES examination according to standardized protocols. Inter-rater reliability and convergent validity were determined and GUSS- and FEES-based diet recommendations were compared. Key Results Inter-rater reliability of GUSS ratings was high (r(s) = 0.8; p < 0.001). Aspiration was identified by the GUSS with a sensitivity of 50%, and specificity of 51.35% (PPV 28%, NPV 73%, LR+ 1.03, LR- 0.97), dysphagia/penetration was identified with 72.97% sensitivity and 35.71% specificity (PPV 75%, NPV 33.33%, LR+ 1.14, LR- 0.76). Agreement between GUSS- and FEES-based diet recommendations was low (r(s) = 0.12, p = 0.42) with consistent NPO (Nil per Os) allocation by GUSS and FEES in only one participant. Conclusions and Inferences The multi-texture screening tool GUSS in its current form, although applicable with good inter-rater reliability, does not detect aspiration in PD patients with acceptable accuracy. Modifications of the GUSS parameters "coughing," "voice change" and "delayed swallowing" might enhance validity. The GUSS' diet recommendations overestimate the need for oral intake restriction in PD patients and should be verified by instrumental swallowing examination.

Published
2021

45. CLOVER-DBS: Algorithm-Guided Deep Brain Stimulation-Programming Based on External Sensor Feedback Evaluated in a Prospective, Randomized, Crossover, Double-Blind, Two-Center Study

Author

Wenzel, Gregor R., primary, Roediger, Jan, additional, Brücke, Christof, additional, Marcelino, Ana Luísa de A., additional, Gülke, Eileen, additional, Pötter-Nerger, Monika, additional, Scholtes, Heleen, additional, Wynants, Kenny, additional, Juárez Paz, León M., additional, and Kühn, Andrea A., additional

Published
2021
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49. Structural connectivity of subthalamic nucleus stimulation for improving freezing of gait

Author

Strelow, Joshua N., primary, Baldermann, Juan C., additional, Dembek, Till A., additional, Jergas, Hannah, additional, Petry-Schmelzer, Jan N., additional, Schott, Frederik, additional, Dafsari, Haidar, additional, Moll, Christian K.E., additional, Hamel, Wolfgang, additional, Gulberti, Alessandro, additional, Visser-Vandewalle, Veerle, additional, Fink, Gereon R., additional, Pötter-Nerger, Monika, additional, and Barbe, Michael T., additional

Published
2021
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50. Reduced Risk of Reoperations With Modern Deep Brain Stimulator Systems: Big Data Analysis From a United States Claims Database

Author

Wu, Chengyuan, Nagel, Sean J, Agarwal, Rahul, Pötter-Nerger, Monika, Hamel, Wolfgang, Sharan, Ashwini, Connolly, Allison T, Cheeran, Binith, Larson, Paul S, Wu, Chengyuan, Nagel, Sean J, Agarwal, Rahul, Pötter-Nerger, Monika, Hamel, Wolfgang, Sharan, Ashwini, Connolly, Allison T, Cheeran, Binith, and Larson, Paul S

Abstract

Objective: There have been significant improvements in the design and manufacturing of deep brain stimulation (DBS) systems, but no study has considered the impact of modern systems on complications. We sought to compare the relative occurrence of reoperations after de novo implantation of modern and traditional DBS systems in patients with Parkinson's disease (PD) or essential tremor (ET) in the United States. Design: Retrospective, contemporaneous cohort study. Setting: Multicenter data from the United States Centers for Medicare and Medicaid Services administrative claims database between 2016 and 2018. Participants: This population-based sample consisted of 5,998 patients implanted with a DBS system, of which 3,869 patients had a de novo implant and primary diagnosis of PD or ET. Follow-up of 3 months was available for 3,810 patients, 12 months for 3,561 patients, and 24 months for 1,812 patients. Intervention: Implantation of a modern directional (MD) or traditional omnidirectional (TO) DBS system. Primary and Secondary Outcome Measures: We hypothesized that MD systems would impact complication rates. Reoperation rate was the primary outcome. Associated diagnoses, patient characteristics, and implanting center details served as covariates. Kaplan-Meier analysis was performed to compare rates of event-free survival and regression models were used to determine covariate influences. Results: Patients implanted with modern systems were 36% less likely to require reoperation, largely due to differences in acute reoperations and intracranial lead reoperations. Risk reduction persisted while accounting for practice differences and implanting center experience. Risk reduction was more pronounced in patients with PD. Conclusions: In the first multicenter analysis of device-related complications including modern DBS systems, we found that modern systems are associated with lower reoperation rates. This risk profile should be carefully considered during device selection f

Published
2021

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