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Your search keyword '"Péter Sóti"' showing total 2 results
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2 results on '"Péter Sóti"'

1. The Effect of Surfactants and pH Modifying Agents on the Dissolution and Permeation of Pimobendan

Author

Petra Tőzsér, Luca L. Kovács, Szabina Kádár, Dóra Csicsák, Péter Sóti, Gergely Völgyi, Bálint Sinkó, Zsombor K. Nagy, and Enikő Borbás

Subjects
General Chemical Engineering
Abstract

Solubility and permeability are key parameters for establishing in vitro-in vivo correlation for poorly water-soluble active pharmaceutical ingredients (APIs). Recent studies demonstrate that not only solubility, but also effective permeability of the API may change due to the addition of solubilizing agents, and there is a certain mathematical relation between these physicochemical parameters. The aim of this study was to show the importance of early screening of solubility and permeability in presence of additives in order to achieve the expected bioavailability of the API. In this work, the effect of surfactants and microenvironmental pH modifiers were in focus, and pimobendan was chosen as model drug.In the case of pH modifiers, the equilibrium solubility of the API increased, while the permeability decreased significantly. No negative effect was observed for two surfactants at low additive levels, but these two additives also exhibited a slightly negative effect on permeability when used at higher concentrations. In the simultaneous dissolution-permeation studies the surfactants-containing formulation was found to have slightly higher flux than the pH-modifier-containing one. It can be due to the phenomenon that the dissolution of the active substance can be enhanced by these surfactants without any significant permeability reducing effect.The results obtained from the present study clearly demonstrate the importance of studying drug-additive interactions in every step of formulation development and based on these, the selection of the appropriate quality and quantity of additives. In addition, the results also underline the significance of performing simultaneous dissolution-permeation studies to predict bioavailability.

Published
2023
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2. A dialogical perspective on composition: the classroom responds to gadamer A dialogical perspective on composition: the classroom responds to gadamer

Author

Peter Sotiriou

Subjects
English Language, English, Language and Literature, English literature, PR1-9680
Abstract

Composition theory has in the past two decades been informed by three pedagogical movements. The older process pedagogy foregrounds the student writer in the act of composing. In the past decade, reader response theory has spoken to classroom practice in the forms of collaborative learning and writing across the curriculum pedagogics. In both of these pedagogics, the student writer is perceived as an initiate in a specialized community of writers, and her goal is to master the reading and writing conventions that shape the knowledge in that chosen field. Finally, in the pedagogics of E.D. Hirsch and Allan Bloom, there is a focus on determining valid textual meaning: for these theorists, student writers need to learn their culture before they can engage in any meaningful reading and writing. Composition theory has in the past two decades been informed by three pedagogical movements. The older process pedagogy foregrounds the student writer in the act of composing. In the past decade, reader response theory has spoken to classroom practice in the forms of collaborative learning and writing across the curriculum pedagogics. In both of these pedagogics, the student writer is perceived as an initiate in a specialized community of writers, and her goal is to master the reading and writing conventions that shape the knowledge in that chosen field. Finally, in the pedagogics of E.D. Hirsch and Allan Bloom, there is a focus on determining valid textual meaning: for these theorists, student writers need to learn their culture before they can engage in any meaningful reading and writing.

Published
2008

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