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8 results on '"Pérez-Ortega, Laura"'

1. Next-generation BCMA-targeted chimeric antigen receptor CARTemis-1: the impact of manufacturing procedure on CAR T-cell features

Author

Sierro-Martínez, Belén, Escamilla-Gómez, Virginia, Pérez-Ortega, Laura, Guijarro-Albaladejo, Beatriz, Hernández-Díaz, Paola, de la Rosa-Garrido, María, Lara-Chica, Maribel, Rodríguez-Gil, Alfonso, Reguera-Ortega, Juan Luis, Sanoja-Flores, Luzalba, Arribas-Arribas, Blanca, Montiel-Aguilera, Miguel Ángel, Carmona, Gloria, Robles, Maria Jose, Caballero-Velázquez, Teresa, Briones, Javier, Einsele, Hermann, Hudecek, Michael, Pérez-Simón, Jose Antonio, and García-Guerrero, Estefanía

Published
2024
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2. Role of allogeneic hematopoietic cell transplant for relapsed/refractory aggressive B-cell lymphomas in the CART era

Author

Generalitat de Catalunya, Mussetti, Alberto, Bento, Leyre, Bastos-Oreiro, Mariana, Rius-Sansalvador, Blanca, Albo, Carmen, Bailen, Rebeca, Barba, Pere, Benzaquén, Ana, Briones, Javier, Caballero, Ana Carolina, Campos, Antonio, Español, Ignacio, Ferrá, Christelle, Garzón López, Sebastián, González-Sierra, Pedro Antonio, Guerra, Luisa María, Hernani, Rafael, Iacoboni, Gloria, Jiménez-Ubieto, Ana, Kwon, Mi, López-Corral, Lucía, López-Godino, Oriana, Martínez, Carmen, Martínez-Cibrián, Nuria, Montoro, Juan, Pérez-Ortega, Laura, Ortí, Guillermo, Valentín Ortiz-Maldonado, Pascual, M. Jesús, Perera, María, Pérez, Antonio, Reguera, Juan Luis, Sánchez, José M., Sanz, Jaime, Torrent, Anna, Yáñez, Lucrecia, Varela, Rosario, Ceberio-Echechipia, Izaksun, Caballero, Dolores, Sureda, Anna, Generalitat de Catalunya, Mussetti, Alberto, Bento, Leyre, Bastos-Oreiro, Mariana, Rius-Sansalvador, Blanca, Albo, Carmen, Bailen, Rebeca, Barba, Pere, Benzaquén, Ana, Briones, Javier, Caballero, Ana Carolina, Campos, Antonio, Español, Ignacio, Ferrá, Christelle, Garzón López, Sebastián, González-Sierra, Pedro Antonio, Guerra, Luisa María, Hernani, Rafael, Iacoboni, Gloria, Jiménez-Ubieto, Ana, Kwon, Mi, López-Corral, Lucía, López-Godino, Oriana, Martínez, Carmen, Martínez-Cibrián, Nuria, Montoro, Juan, Pérez-Ortega, Laura, Ortí, Guillermo, Valentín Ortiz-Maldonado, Pascual, M. Jesús, Perera, María, Pérez, Antonio, Reguera, Juan Luis, Sánchez, José M., Sanz, Jaime, Torrent, Anna, Yáñez, Lucrecia, Varela, Rosario, Ceberio-Echechipia, Izaksun, Caballero, Dolores, and Sureda, Anna

Abstract

Anti-CD19 chimeric antigen receptor T cells (CART) has rapidly been adopted as the standard third-line therapy to treat aggressive B-cell lymphomas (ABCL) after failure of second-line therapy despite the lack of direct comparisons with allogeneic hematopoietic cell transplantation (alloHCT)-based strategies. Using the Grupo Español de Trasplante y Terapia Celular (GETH-TC) registry, we selected patients with the following characteristics: CART or alloHCT performed between 2016 and 2021; ≥18 years old; ABCL diagnosis; ≥2 lines of therapy; and either anti-CD19 CART or alloHCT as therapy at relapse. The analysis included a total of 316 (CART = 215, alloHCT = 101) patients. Median follow-up was 15 and 36 months for the CART and alloHCT cohorts, respectively. In the multivariate analysis, CART was confirmed to be similar to alloHCT for the primary study endpoint (progression-free survival) (hazard ratio [HR] 0.92, CI95%:0.56–1.51, p = 0.75). Furthermore, when the analysis was limited to only patients with chemo-sensitive diseases (complete and partial response) at infusion (CART = 26, alloHCT=93), no differences were reported (progression-free survival at month +18: 65% versus 55%, p = 0.59). However, CART had lower non-relapse mortality (HR 0.34, 95% CI: 0.13–0.85, p = 0.02). Given the lower toxicity and similar survival outcomes, these results suggest the use of CART before alloHCT.

Published
2023

3. Correction: Role of allogeneic hematopoietic cell transplant for relapsed/refractory aggressive B-cell lymphomas in the CART era

Author

Mussetti, Alberto, primary, Bento, Leyre, additional, Bastos-Oreiro, Mariana, additional, Rius-Sansalvador, Blanca, additional, Albo, Carmen, additional, Bailen, Rebeca, additional, Barba, Pere, additional, Benzaquén, Ana, additional, Briones, Javier, additional, Caballero, Ana Carolina, additional, Campos, António, additional, Español, Ignacio, additional, Ferra, Christelle, additional, López, Sebastián Garzón, additional, González Sierra, Pedro Antonio, additional, Guerra, Luisa Maria, additional, Hernani, Rafael, additional, Iacoboni, Gloria, additional, Jiménez-Ubieto, Ana, additional, Kwon, Mi, additional, Corral, Lucía López, additional, López-Godino, Oriana, additional, Munoz, Maria Carmen Martinez, additional, Martínez-Cibrián, Nuria, additional, Gómez, Juan Montoro, additional, Pérez-Ortega, Laura, additional, Ortí, Guillermo, additional, Ortiz-Maldonado, Valentín, additional, Pascual, Maria-Jesús, additional, Perera, María, additional, Perez, Antonio, additional, Reguera, Juan Luis, additional, Sanchez, Jose M., additional, Sanz, Jaime, additional, Torrent, Anna, additional, Yáñez, Lucrecia, additional, Varela, Rosario, additional, Echechipia, Izaksun Ceberio, additional, Caballero, Dolores, additional, and Sureda, Anna, additional

Published
2023
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4. Role of allogeneic hematopoietic cell transplant for relapsed/refractory aggressive B-cell lymphomas in the CART era

Author

Mussetti, Alberto, primary, Bento, Leyre, additional, Bastos-Oreiro, Mariana, additional, Rius.Sansalvador, B., additional, Albo, Carmen, additional, Bailen, Rebeca, additional, Barba, Pere, additional, Benzaquén, Ana, additional, Briones, Javier, additional, Caballero, Ana Carolina, additional, Campos, António, additional, Español, Ignacio, additional, Ferra, Christelle, additional, López, Sebastián Garzón, additional, González Sierra, Pedro Antonio, additional, Guerra, Luisa Maria, additional, Hernani, Rafael, additional, Iacoboni, Gloria, additional, Jiminez Ubieto, Ana Isabel, additional, Kwon, Mi, additional, Corral, Lucía López, additional, López-Godino, Oriana, additional, Munoz, Maria Carmen Martinez, additional, Martínez-Cibrián, Nuria, additional, Gómez, Juan Montoro, additional, Pérez-Ortega, Laura, additional, Ortí, Guillermo, additional, Ortiz-Maldonado, Valentín, additional, Pascual, Maria-Jesús, additional, Perera, María, additional, Perez, Antonio, additional, Reguera, Juan Luis, additional, Sanchez, Jose M., additional, Sanz, Jaime, additional, Torrent, Anna, additional, Yáñez, Lucrecia, additional, Varela, Rosario, additional, Echechipia, Izaksun Ceberio, additional, Caballero, Dolores, additional, and Sureda, Anna, additional

Published
2023
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5. Role of Allogeneic Hematopoietic Cell Transplant for Relapsed/Refractory Large B-Cell Lymphomas in the CART Era

Author

Mussetti, Alberto, primary, Bento, Leyre, additional, Bastos-Oreiro, Mariana, additional, Albo, Carmen, additional, Bailen, Rebeca, additional, Barba, Pere, additional, Benzaquén, Ana, additional, Briones, Javier, additional, Caballero, Ana Carolina, additional, Campos, António, additional, Español, Ignacio, additional, Ferra, Christelle, additional, Garzón López, Sebastián, additional, González Sierra, Pedro Antonio, additional, Guerra, Luisa Maria, additional, Hernani, Rafael, additional, Iacoboni, Gloria, additional, Jiminez Ubieto, Ana Isabel, additional, Kwon, Mi, additional, López Corral, Lucía, additional, López-Godino, Oriana, additional, Martinez Munoz, Maria Carmen, additional, Martínez-Cibrián, Nuria, additional, Montoro Gómez, Juan, additional, Pérez-Ortega, Laura, additional, Ortí, Guillermo, additional, Ortiz-Maldonado, Valentín, additional, Pascual, Maria-Jesús, additional, Perera, María, additional, Perez, Antonio, additional, Reguera, Juan Luis, additional, Sanchez, Jose M., additional, Sanz, Jaime, additional, Torrent, Anna, additional, Yáñez, Lucrecia, additional, Varela, Rosario, additional, Ceberio Echechipia, Izaksun, additional, Caballero, Dolores, additional, and Sureda, Anna, additional

Published
2022
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6. Cytopenias in CAR-T Cell Therapy and Use of Transfusion Resources in Adult Patients with Lymphoproliferative Disorders

Author

Mezquita, Lucía, primary, Mingot, Maria Eva, additional, Alcalde, Patricia, additional, Sánchez-Llorca, Paula, additional, Camuña-Correa, Javier, additional, Reguera, Juan Luis, additional, Martínez-Cibrian, Nuria, additional, Blazquez-Goñi, Cristina, additional, Escamilla Gomez, Virginia, additional, Pérez-Ortega, Laura, additional, Serrano, Dolores, additional, and Perez-Simon, Jose A., additional

Published
2021
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7. New Optimized Academic Anti-BCMA CAR (CARTemis-1): How Does the Manufacturing Process Impact CAR-T Cell Features?

Author

Sierro-Martínez, Belén, Escamilla Gomez, Virginia, Perez-Ortega, Laura, Guijarro-Albaladejo, Beatriz, Hernández-Díaz, Paola, de la Rosa-Garrido, María, Lara-Chica, Maribel, Reguera, Juan Luis, Sanoja Flores, Luzalba, Arribas-Arribas, Blanca, Montiel-Aguilera, Miguel-Ángel, Carmona, Gloria, Robles, Maria-Jose, Caballero, Teresa, Briones, Javier, Einsele, Hermann, Hudecek, Michael, Pérez-Simón, Jose A., and Garcia-Guerrero, Estefania

Published
2023
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