2,025 results on '"Pérez-Gil A"'
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2. Asentamientos informales y arquitectura vernácula: viejos y nuevos debates
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Javier Pérez Gil
- Subjects
asentamientos informales ,arquitectura vernácula ,patrimonio cultural ,teoría de la arquitectura ,Cities. Urban geography ,GF125 - Abstract
En las últimas décadas se han suscitado dos debates en torno a los asentamientos informales y su relación con la arquitectura vernácula. El primero gira en torno a si esa arquitectura y conjuntos pueden considerarse arquitectura vernácula. El segundo, más reciente y prácticamente silenciado desde las instituciones, se pregunta si aquellos pueden alcanzar la categoría de patrimonio cultural. Este artículo pretende demostrar que ambos debates no dependen tanto de la consideración epistemológica de los asentamientos informales como de la previa conceptualización de la arquitectura vernácula, y aboga por aplicar un criterio cultural y plenamente consecuente con nuestros principios democráticos y patrimoniales.
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- 2024
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3. Process intensification in the continuous dehydrogenation of methylcyclohexane to toluene
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Pérez-Gil, Susana, Santos-Moreno, Sergio, García, Cristina Diñeiro, and Madurga, Belén Maestro
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- 2024
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4. Reseña del libro Detritus, desechos, lo abyecto de François Dagognet (2023). Obsesión por el brillo y la higiene
- Author
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Rodrigo Pérez Gil
- Subjects
reseña ,reseña de libro ,dagognet ,filosofía ,ecología ,History of scholarship and learning. The humanities ,AZ20-999 ,Social sciences (General) ,H1-99 - Abstract
«En este libro, Dagognet quiere privilegiar el sustrato, en contravía de la metafísica tradicional, idealista, que minimiza el soporte en beneficio de lo que él difunde. Es el mismo gusto del burgués a la hora de apreciar un libro: le importa más lo que se dice que la manera como se dice. El autor quiere revalorizar lo sucio, lo descompuesto y lo pobre, en particular el polvo, la arena o el guijarro...»
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- 2023
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5. A new small carder bee species from the eastern Canary Islands (Hymenoptera, Megachilidae, Anthidiini)
- Author
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Nicolas J. Vereecken, Carlos Ruiz, Leon Marshall, Mónica Pérez-Gil, Jean-Marc Molenberg, Bernhard Jacobi, Francisco La Roche, and Jessica R. Litman
- Subjects
Zoology ,QL1-991 - Abstract
Recent field surveys in the eastern Canary Islands (Spain), followed by contributions of new occurrence records through the citizen science platform iNaturalist.com and the social media photo repository Flickr.com have revealed the presence of an overlooked small carder bee species (genus Pseudoanthidium Friese (Megachilidae: Anthidiini)) on the islands of Lanzarote and Fuerteventura. Here, we combined morphology, DNA barcodes (mitochondrial cytochrome c oxidase subunit I, COI) and ecological data (distribution, altitudinal ranges and environmental niche classification) to describe this species as Pseudoanthidium (Pseudoanthidium) jacobii sp. nov. We provide an illustrated description along with diagnostic morphological characters to separate it from P. (P.) canariense (Mavromoustakis, 1954), the only other congeneric species known from the neighbouring islands of La Gomera, Tenerife and Gran Canaria and from which it is separated by a genetic distance of 2.7%. We also evaluated the extent of shared environmental niche space among the two Pseudoanthidium species, and our results show a significant difference in elevation range as well as a very small (less than 1%) overlap between the modelled climatic niche of P. jacobii and that of P. canariense. Given the extremely restricted geographic distribution and the fragile and isolated nature of the habitat and host plants of this new island endemic species, we assign it an IUCN conservation status of “EN” (endangered) and discuss avenues for future research on the ecology and conservation of wild bees in the Canary Islands and neighbouring regions.
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- 2023
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6. Sex, Genotype, and Liver Volume Progression as Risk of Hospitalization Determinants in Autosomal Dominant Polycystic Liver Disease
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Ambrose, John C., Arumugam, Prabhu, Bevers, Roel, Bleda, Marta, Boardman-Pretty, Freya, Boustred, Christopher R., Brittain, Helen, Caulfield, Mark J., Chan, Georgia C., Elgar, Greg, Fowler, Tom, Giess, Adam, Hamblin, Angela, Henderson, Shirley, Hubbard, Tim J.P., Jackson, Rob, Jones, Louise J., Kasperaviciute, Dalia, Kayikci, Melis, Kousathanas, Athanasios, Lahnstein, Lea, Leigh, Sarah E.A., Leong, Ivonne U.S., Lopez, Javier F., Maleady-Crowe, Fiona, McEntagart, Meriel, Minneci, Federico, Moutsianas, Loukas, Mueller, Michael, Murugaesu, Nirupa, Need, Anna C., O’Donovan, Peter, Odhams, Chris A., Patch, Christine, Pereira, Mariana Buongermino, Perez-Gil, Daniel, Pullinger, John, Rahim, Tahrima, Rendon, Augusto, Rogers, Tim, Savage, Kevin, Sawant, Kushmita, Scott, Richard H., Siddiq, Afshan, Sieghart, Alexander, Smith, Samuel C., Sosinsky, Alona, Stuckey, Alexander, Tanguy, Mélanie, Taylor Tavares, Ana Lisa, Thomas, Ellen R.A., Thompson, Simon R., Tucci, Arianna, Welland, Matthew J., Williams, Eleanor, Witkowska, Katarzyna, Wood, Suzanne M., Schönauer, Ria, Sierks, Dana, Boerrigter, Melissa, Jawaid, Tabinda, Caroff, Lea, Audrezet, Marie-Pierre, Friedrich, Anja, Shaw, Melissa, Degenhardt, Jan, Forberger, Mirjam, de Fallois, Jonathan, Bläker, Hendrik, Bergmann, Carsten, Gödiker, Juliana, Schindler, Philipp, Schlevogt, Bernhard, Müller, Roman-U., Berg, Thomas, Patterson, Ilse, Griffiths, William J., Sayer, John A., Popp, Bernt, Torres, Vicente E., Hogan, Marie C., Somlo, Stefan, Watnick, Terry J., Nevens, Frederik, Besse, Whitney, Cornec-Le Gall, Emilie, Harris, Peter C., Drenth, Joost P.H., and Halbritter, Jan
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- 2024
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7. A gene pathogenicity tool “GenePy” identifies missed biallelic diagnoses in the 100,000 Genomes Project
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Ambrose, J.C., Arumugam, P., Bevers, R., Bleda, M., Boardman-Pretty, F., Boustred, C.R., Brittain, H., Brown, M.A., Caulfield, M.J., Chan, G.C., Giess, A., Griffin, J.N., Hamblin, A., Henderson, S., Hubbard, T.J.P., Jackson, R., Jones, L.J., Kasperaviciute, D., Kayikci, M., Kousathanas, A., Lahnstein, L., Lakey, A., Leigh, S.E.A., Leong, I.U.S., Lopez, F.J., Maleady-Crowe, F., McEntagart, M., Minneci, F., Mitchell, J., Moutsianas, L., Mueller, M., Murugaesu, N., Need, A.C., O‘Donovan, P., Odhams, C.A., Patch, C., Perez-Gil, D., Pereira, M.B., Pullinger, J., Rahim, T., Rendon, A., Rogers, T., Savage, K., Sawant, K., Scott, R.H., Siddiq, A., Sieghart, A., Smith, S.C., Sosinsky, A., Stuckey, A., Tanguy, M., Taylor Tavares, A.L., Thomas, E.R.A., Thompson, S.R., Tucci, A., Welland, M.J., Williams, E., Witkowska, K., Wood, S.M., Zarowiecki, M., Seaby, Eleanor G., Leggatt, Gary, Cheng, Guo, Thomas, N. Simon, Ashton, James J., Stafford, Imogen, Baralle, Diana, Rehm, Heidi L., O’Donnell-Luria, Anne, and Ennis, Sarah
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- 2024
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8. First report of Aphria latifrons (Diptera, Tachinidae, Leskiini) in the Canary Islands
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Daniel Suárez, David Lugo, Mónica Pérez-Gil, Gustavo Peña, and Carlos Ruiz
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new record ,distribution ,parasitoid ,Macaronesia ,Biology (General) ,QH301-705.5 - Abstract
The Canary Islands are an archipelago of volcanic origin, located off north-west Africa comprising eight islands. Fuerteventura and Lanzarote are the oldest (20 and 15 millon years old, respectively) and the easternmost islands. The order Diptera is one of the most relevant taxa in the Canary Islands as they constitute the second highest species richness. Within this order, the family Tachinidae is especially interesting as all species are endoparasitoids of arthropods and most species play a key role as pollinators. In the Canary Islands, the family comprises 52 species, with Fuerteventura and Lanzarote harbouring up to 20 species each.Aphria latifrons, a Palaearctic tachinid fly, is reported for the first time from the Canary Islands, where it was found on Fuerteventura and Lanzarote. Morphological examination was carried out and the first known barcode of the species is presented. Its potential distribution and source of origin are discussed.
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- 2023
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9. Na casa das onças: xamanismo e performance na antropologia de E. Jean Langdon
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Laura Pérez Gil and Luciana Hartmann
- Subjects
Esther Jean Langdon ,Siona ,shamanism ,indigenous health ,performance studies ,antropólogas ,History of Civilization ,CB3-482 - Abstract
Raised and educated in the United States, Esther Jean Langdon conducted intensive field research among the Siona (Western Tukanoan), in the Colombian Amazon and has worked, for the last four decades, at the Universidade Federal de Santa Catarina, in the south of Brazil. In this article, we look over her intellectual production and emphasize resonances among the subjects around which her work is articulated: indigenous health, shamanism, and performance. From these considerations, we highlight the main concepts—practice, dialogicity and emergence—that characterize her theoretical and ethnographical contributions.
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- 2023
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10. Why the courtyards of historical palaces should not be roofed in
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Javier Pérez Gil and Rodrigo Almonacid
- Subjects
historical palaces ,courtyard ,conservation ,architectural theory ,roofs ,Arts in general ,NX1-820 - Abstract
There is a trend to roof over the courtyards of historical palaces and similar great buildings with an eye to conservation or to expanding their range of functions. This tendency is being popularized by major architects and barely a voice is raised against it. However, from the viewpoint of theory and heritage, such actions are not to be recommended. In line with some international documents on cultural heritage, several architectural, perceptual and functional arguments show that, in order to preserve the cultural authenticity of courtyards, it would be advisable to avoid covering them. A courtyard is by definition an open space. Covering it, even with an apparently harmless glazed roof, radically affects its architectural essence and how it is experienced. Hence, such projects should not be accepted in a generalized and uncritical manner. It is best for courtyards to be left as courtyards, not as rooms with skylights.
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- 2023
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11. Biallelic CRELD1 variants cause a multisystem syndrome, including neurodevelopmental phenotypes, cardiac dysrhythmias, and frequent infections
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Borras, Silvia, Clark, Caroline, Dean, John, Miedzybrodzka, Zosia, Ross, Alison, Tennant, Stephen, Dabir, Tabib, Donnelly, Deirdre, Humphreys, Mervyn, Magee, Alex, McConnell, Vivienne, McKee, Shane, McNerlan, Susan, Morrison, Patrick J., Rea, Gillian, Stewart, Fiona, Cole, Trevor, Cooper, Nicola, Cooper-Charles, Lisa, Cox, Helen, Islam, Lily, Jarvis, Joanna, Keelagher, Rebecca, Lim, Derek, McMullan, Dominic, Morton, Jenny, Naik, Swati, O’Driscoll, Mary, Ong, Kai-Ren, Osio, Deborah, Ragge, Nicola, Turton, Sarah, Vogt, Julie, Williams, Denise, Bodek, Simon, Donaldson, Alan, Hills, Alison, Low, Karen, Newbury-Ecob, Ruth, Norman, Andrew M., Roberts, Eileen, Scurr, Ingrid, Smithson, Sarah, Tooley, Madeleine, Abbs, Steve, Armstrong, Ruth, Dunn, Carolyn, Holden, Simon, Park, Soo-Mi, Paterson, Joan, Raymond, Lucy, Reid, Evan, Sandford, Richard, Simonic, Ingrid, Tischkowitz, Marc, Woods, Geoff, Bradley, Lisa, Comerford, Joanne, Green, Andrew, Lynch, Sally, McQuaid, Shirley, Mullaney, Brendan, Berg, Jonathan, Goudie, David, Mavrak, Eleni, McLean, Joanne, McWilliam, Catherine, Reavey, Eleanor, Azam, Tara, Cleary, Elaine, Jackson, Andrew, Lam, Wayne, Lampe, Anne, Moore, David, Porteous, Mary, Baple, Emma, Baptista, Júlia, Brewer, Carole, Castle, Bruce, Kivuva, Emma, Owens, Martina, Rankin, Julia, Shaw-Smith, Charles, Turner, Claire, Turnpenny, Peter, Tysoe, Carolyn, Bradley, Therese, Davidson, Rosemarie, Gardiner, Carol, Joss, Shelagh, Kinning, Esther, Longman, Cheryl, McGowan, Ruth, Murday, Victoria, Pilz, Daniela, Tobias, Edward, Whiteford, Margo, Williams, Nicola, Barnicoat, Angela, Clement, Emma, Faravelli, Francesca, Hurst, Jane, Jenkins, Lucy, Jones, Wendy, Ajith Kumar, V.K., Lees, Melissa, Loughlin, Sam, Male, Alison, Morrogh, Deborah, Rosser, Elisabeth, Scott, Richard, Wilson, Louise, Beleza, Ana, Deshpande, Charu, Flinter, Frances, Holder, Muriel, Irving, Melita, Izatt, Louise, Josifova, Dragana, Mohammed, Shehla, Molenda, Aneta, Robert, Leema, Roworth, Wendy, Ruddy, Deborah, Ryten, Mina, Yau, Shu, Bennett, Christopher, Blyth, Moira, Campbell, Jennifer, Coates, Andrea, Dobbie, Angus, Hewitt, Sarah, Hobson, Emma, Jackson, Eilidh, Jewell, Rosalyn, Kraus, Alison, Prescott, Katrina, Sheridan, Eamonn, Thomson, Jenny, Bradshaw, Kirsty, Dixit, Abhijit, Eason, Jacqueline, Haines, Rebecca, Harrison, Rachel, Mutch, Stacey, Sarkar, Ajoy, Searle, Claire, Shannon, Nora, Sharif, Abid, Suri, Mohnish, Vasudevan, Pradeep, Canham, Natalie, Ellis, Ian, Greenhalgh, Lynn, Howard, Emma, Stinton, Victoria, Swale, Andrew, Weber, Astrid, Banka, Siddharth, Breen, Catherine, Briggs, Tracy, Burkitt-Wright, Emma, Chandler, Kate, Clayton-Smith, Jill, Donnai, Dian, Douzgou, Sofia, Gaunt, Lorraine, Jones, Elizabeth, Kerr, Bronwyn, Langley, Claire, Metcalfe, Kay, Smith, Audrey, Wright, Ronnie, Bourn, David, Burn, John, Fisher, Richard, Hellens, Steve, Henderson, Alex, Montgomery, Tara, Splitt, Miranda, Straub, Volker, Wright, Michael, Zwolinski, Simon, Allen, Zoe, Bernhard, Birgitta, Brady, Angela, Brooks, Claire, Busby, Louise, Clowes, Virginia, Ghali, Neeti, Holder, Susan, Ibitoye, Rita, Wakeling, Emma, Blair, Edward, Carmichael, Jenny, Cilliers, Deirdre, Clasper, Susan, Gibbons, Richard, Kini, Usha, Lester, Tracy, Nemeth, Andrea, Poulton, Joanna, Price, Sue, Shears, Debbie, Stewart, Helen, Wilkie, Andrew, Albaba, Shadi, Baker, Duncan, Balasubramanian, Meena, Johnson, Diana, Parker, Michael, Quarrell, Oliver, Stewart, Alison, Willoughby, Josh, Crosby, Charlene, Elmslie, Frances, Homfray, Tessa, Jin, Huilin, Lahiri, Nayana, Mansour, Sahar, Marks, Karen, McEntagart, Meriel, Saggar, Anand, Tatton-Brown, Kate, Butler, Rachel, Clarke, Angus, Corrin, Sian, Fry, Andrew, Kamath, Arveen, McCann, Emma, Mugalaasi, Hood, Pottinger, Caroline, Procter, Annie, Sampson, Julian, Sansbury, Francis, Varghese, Vinod, Baralle, Diana, Callaway, Alison, Cassidy, Emma J., Daniels, Stacey, Douglas, Andrew, Foulds, Nicola, Hunt, David, Kharbanda, Mira, Lachlan, Katherine, Mercer, Catherine, Side, Lucy, Temple, I. Karen, Wellesley, Diana, Ambrose, J.C., Arumugam, P., Baple, E.L., Bleda, M., Boardman-Pretty, F., Boissiere, J.M., Boustred, C.R., Caulfield, M.J., Chan, G.C., Craig, C.E.H., Daugherty, L.C., de Burca, A., Devereau, A., Elgar, G., Foulger, R.E., Fowler, T., FurióTarí, P., Hackett, J.M., Halai, D., Hamblin, A., Henderson, S., Holman, J.E., Hubbard, T.J.P., Ibáñez, K., Jackson, R., Jones, L.J., Kasperaviciute, D., Kayikci, M., Lahnstein, L., Lawson, K., Leigh, S.E.A., Leong, I.U.S., Lopez, F.J., MaleadyCrowe, F., Mason, J., McDonagh, E.M., Moutsianas, L., Mueller, M., Murugaesu, N., Need, A.C., Odhams, C.A., Patch, C., Perez-Gil, D., Polychronopoulos, D., Pullinger, J., Rahim, T., Rendon, A., Riesgo-Ferreiro, P., Rogers, T., Ryten, M., Savage, K., Sawant, K., Scott, R.H., Siddiq, A., Sieghart, A., Smedley, D., Smith, K.R., Sosinsky, A., Spooner, W., Stevens, H.E., Stuckey, A., Sultana, R., Thomas, E.R.A., Thompson, S.R., Tucci, A., Walsh, E., Watters, S.A., Welland, M.J., Williams, E., Witkowska, K., Acosta, Maria T., Adam, Margaret, Adams, David R., Agrawal, Pankaj B., Alejandro, Mercedes E., Alvey, Justin, Amendola, Laura, Andrews, Ashley, Ashley, Euan A., Azamian, Mahshid S., Bacino, Carlos A., Bademci, Guney, Baker, Eva, Balasubramanyam, Ashok, Baldridge, Dustin, Bale, Jim, Bamshad, Michael, Barbouth, Deborah, Bayrak-Toydemir, Pinar, Beck, Anita, Beggs, Alan H., Behrens, Edward, Bejerano, Gill, Bennet, Jimmy, Berg-Rood, Beverly, Bernstein, Jonathan A., Berry, Gerard T., Bican, Anna, Bivona, Stephanie, Blue, Elizabeth, Bohnsack, John, Bonnenmann, Carsten, Bonner, Devon, Botto, Lorenzo, Boyd, Brenna, Briere, Lauren C., Brokamp, Elly, Brown, Gabrielle, Burke, Elizabeth A., Burrage, Lindsay C., Butte, Manish J., Byers, Peter, Byrd, William E., Carey, John, Carrasquillo, Olveen, Peter Chang, Ta Chen, Chanprasert, Sirisak, Chao, Hsiao-Tuan, Clark, Gary D., Coakley, Terra R., Cobban, Laurel A., Cogan, Joy D., Coggins, Matthew, Cole, F. Sessions, Colley, Heather A., Cooper, Cynthia M., Craigen, William J., Crouse, Andrew B., Cunningham, Michael, D'Souza, Precilla, Dai, Hongzheng, Dasari, Surendra, Davids, Mariska, Dayal, Jyoti G., Deardorff, Matthew, Dell'Angelica, Esteban C., Dhar, Shweta U., Dipple, Katrina, Doherty, Daniel, Dorrani, Naghmeh, Douine, Emilie D., Draper, David D., Duncan, Laura, Earl, Dawn, Eckstein, David J., Emrick, Lisa T., Eng, Christine M., Esteves, Cecilia, Estwick, Tyra, Falk, Marni, Fernandez, Liliana, Ferreira, Carlos, Fieg, Elizabeth L., Findley, Laurie C., Fisher, Paul G., Fogel, Brent L., Forghani, Irman, Fresard, Laure, Gahl, William A., Glass, Ian, Godfrey, Rena A., Golden-Grant, Katie, Goldman, Alica M., Goldstein, David B., Grajewski, Alana, Groden, Catherine A., Gropman, Andrea L., Gutierrez, Irma, Hahn, Sihoun, Hamid, Rizwan, Hanchard, Neil A., Hassey, Kelly, Hayes, Nichole, High, Frances, Hing, Anne, Hisama, Fuki M., Holm, Ingrid A., Hom, Jason, Horike-Pyne, Martha, Huang, Alden, Huang, Yong, Isasi, Rosario, Jamal, Fariha, Jarvik, Gail P., Jarvik, Jeffrey, Jayadev, Suman, Johnston, Jean M., Karaviti, Lefkothea, Kelley, Emily G., Kennedy, Jennifer, Kiley, Dana, Kohane, Isaac S., Kohler, Jennefer N., Krakow, Deborah, Krasnewich, Donna M., Kravets, Elijah, Korrick, Susan, Koziura, Mary, Krier, Joel B., Lalani, Seema R., Lam, Byron, Lam, Christina, Lanpher, Brendan C., Lanza, Ian R., Lau, C. Christopher, LeBlanc, Kimberly, Lee, Brendan H., Lee, Hane, Levitt, Roy, Lewis, Richard A., Lincoln, Sharyn A., Liu, Pengfei, Liu, Xue Zhong, Longo, Nicola, Loo, Sandra K., Loscalzo, Joseph, Maas, Richard L., Macnamara, Ellen F., MacRae, Calum A., Maduro, Valerie V., Majcherska, Marta M., Mak, Bryan, Malicdan, May Christine V., Mamounas, Laura A., Manolio, Teri A., Mao, Rong, Maravilla, Kenneth, Markello, Thomas C., Marom, Ronit, Marth, Gabor, Martin, Beth A., Martin, Martin G., Martínez-Agosto, Julian A., Marwaha, Shruti, McCauley, Jacob, McCormack, Colleen E., McCray, Alexa T., McGee, Elisabeth, Mefford, Heather, Merritt, J. Lawrence, Might, Matthew, Mirzaa, Ghayda, Morava, Eva, Moretti, Paolo M., Morimoto, Marie, Mulvihill, John J., Murdock, David R., Nakano-Okuno, Mariko, Nath, Avi, Nelson, Stan F., Newman, John H., Nicholas, Sarah K., Nickerson, Deborah, Nieves-Rodriguez, Shirley, Novacic, Donna, Oglesbee, Devin, Orengo, James P., Pace, Laura, Pak, Stephen, Pallais, J. Carl, Papp, Jeanette C., Parker, Neil H., Phillips, John A., Posey, Jennifer E., Potocki, Lorraine, Pusey, Barbara N., Quinlan, Aaron, Raskind, Wendy, Raja, Archana N., Rao, Deepak A., Renteria, Genecee, Reuter, Chloe M., Rives, Lynette, Robertson, Amy K., Rodan, Lance H., Rosenfeld, Jill A., Rosenwasser, Natalie, Ruzhnikov, Maura, Sacco, Ralph, Sampson, Jacinda B., Samson, Susan L., Saporta, Mario, Scott, C. Ron, Schaechter, Judy, Schedl, Timothy, Scott, Daryl A., Sharma, Prashant, Shin, Jimann, Signer, Rebecca, Sillari, Catherine H., Silverman, Edwin K., Sinsheimer, Janet S., Sisco, Kathy, Smith, Edward C., Smith, Kevin S., Solem, Emily, Solnica-Krezel, Lilianna, Stoler, Joan M., Stong, Nicholas, Sullivan, Jennifer A., Sun, Angela, Sutton, Shirley, Sweetser, David A., Sybert, Virginia, Tabor, Holly K., Tamburro, Cecelia P., Tekin, Mustafa, Telischi, Fred, Thorson, Willa, Tifft, Cynthia J., Toro, Camilo, Tran, Alyssa A., Tucker, Brianna M., Urv, Tiina K., Vanderver, Adeline, Velinder, Matt, Viskochil, Dave, Vogel, Tiphanie P., Wahl, Colleen E., Wallace, Stephanie, Walley, Nicole M., Walsh, Chris A., Walker, Melissa, Wambach, Jennifer, Wan, Jijun, Wang, Lee-Kai, Wangler, Michael F., Ward, Patricia A., Wegner, Daniel, Wener, Mark, Wenger, Tara, Perry, Katherine Wesseling, Westerfield, Monte, Wheeler, Matthew T., Whitlock, Jordan, Wolfe, Lynne A., Woods, Jeremy D., Yamamoto, Shinya, Yang, John, Yu, Guoyun, Zastrow, Diane B., Zhao, Chunli, Zuchner, Stephan, Jeffries, Lauren, Mis, Emily K., McWalter, Kirsty, Donkervoort, Sandra, Brodsky, Nina N., Carpier, Jean-Marie, Ji, Weizhen, Ionita, Cristian, Roy, Bhaskar, Morrow, Jon S., Darbinyan, Armine, Iyer, Krishna, Aul, Ritu B., Chao, Katherine R., Cobbold, Laura, Cohen, Stacey, Custodio, Helena M., Drummond-Borg, Margaret, Finanger, Erika, Hainline, Bryan E., Helbig, Ingo, Hewson, Stacy, Hu, Ying, Jackson, Adam, Konstantino, Monica, Leach, Meganne E., McCormick, David, Nelson, Stanley, Nguyen, Joanne, Nugent, Kimberly, Ortega, Lucy, Goodkin, Howard P., Roeder, Elizabeth, Roy, Sani, Sapp, Katie, Saade, Dimah, Sisodiya, Sanjay M., Stals, Karen, Towner, Shelley, Wilson, William, Khokha, Mustafa K., Bönnemann, Carsten G., Lucas, Carrie L., and Lakhani, Saquib A.
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- 2024
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12. Effect of lipid-polymer hybrid nanoparticles on the biophysical function and lateral structure of pulmonary surfactant: Mechanistic in vitro studies
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Xu, You, Cañadas, Olga, Alonso, Alejandro, Franzyk, Henrik, Thakur, Aneesh, Pérez-Gil, Jesús, and Foged, Camilla
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- 2024
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13. Mitochondrial Variation of Bottlenose Dolphins (Tursiops truncatus) from the Canary Islands Suggests a Key Population for Conservation with High Connectivity within the North-East Atlantic Ocean
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Daniel A. Gómez-Lobo, Agustín P. Monteoliva, Antonio Fernandez, Manuel Arbelo, Jesús de la Fuente, Mónica Pérez-Gil, Nuria Varo-Cruz, Antonella Servidio, Enrique Pérez-Gil, Yaisel J. Borrell, and Laura Miralles
- Subjects
Tursiops truncatus ,Canary Islands ,mitochondrial DNA ,D-loop ,special areas of conservation ,conservation genetics ,Veterinary medicine ,SF600-1100 ,Zoology ,QL1-991 - Abstract
In recent decades, worldwide cetacean species have been protected, but they are still threatened. The bottlenose dolphin (Tursiops truncatus) is a vulnerable keystone species and a useful bioindicator of the health and balance of marine ecosystems in oceans all over the world. The genetic structure of the species is shaped by their niche specialization (along with other factors), leading to the classification of two ecotypes: coastal and pelagic. In this study, the genetic diversity, population structure, and ecotypes of bottlenose dolphins from the Canary Islands were assessed through the analysis of 49 new samples from biopsies and from stranded animals using the 636 bp portion of the mitochondrial control region and 343 individuals from databases (n = 392). The results reveal high genetic diversity in Canarian bottlenose dolphins (Hd = 0.969 and π = 0.0165) and the apparent lack of population genetic structure within this archipelago. High genetic structure (Fst, Φst) was found between the Canary Islands and coastal populations, while little to no structure was found with the pelagic populations. These results suggest that Canarian bottlenose dolphins are part of pelagic ecotype populations in the North Atlantic. The studied Special Areas of Conservation in the Canary Islands may correspond to a hotspot of genetic diversity of the species and could be a strategic area for the conservation of the oceanic ecotype of bottlenose dolphins.
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- 2024
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14. Role of Sleep Apnea and Long-Term CPAP Treatment in the Prognosis of Patients With Melanoma: A Prospective Multicenter Study of 443 Patients
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Gómez-Olivas, Jose Daniel, Campos-Rodriguez, Francisco, Nagore, Eduardo, Martorell, Antonio, García-Rio, Francisco, Cubillos, Carolina, Hernandez, Luis, Bañuls, Jose, Arias, Eva, Ortiz, Pablo, Cabriada, Valentin, Gardeazabal, Juan, Montserrat, Josep Maria, Carrera, Cristina, Masa, Juan Fernando, Gomez de Terreros, Javier, Abad, Jorge, Boada, Adam, Mediano, Olga, Castillo-Garcia, Marta, Chiner, Eusebi, Landete, Pedro, Mayos, Mercedes, Fortuna, Ana, Barbé, Ferrán, Sanchez-de-la-Torre, Manuel, Cano-Pumarega, Irene, Perez-Gil, Amalia, Gomez-Garcia, Teresa, Cullen, Daniela, Somoza, Maria, Formigon, Manuel, Aizpuru, Felipe, Oscullo, Grace, Garcia-Ortega, Alberto, Almendros, Isaac, Farré, Ramón, Gozal, David, and Martinez-Garcia, Miguel Angel
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- 2023
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15. Mechanopathology of biofilm-like Mycobacterium tuberculosis cords
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Mishra, Richa, Hannebelle, Melanie, Patil, Vishal P., Dubois, Anaëlle, Garcia-Mouton, Cristina, Kirsch, Gabriela M., Jan, Maxime, Sharma, Kunal, Guex, Nicolas, Sordet-Dessimoz, Jessica, Perez-Gil, Jesus, Prakash, Manu, Knott, Graham W., Dhar, Neeraj, McKinney, John D., and Thacker, Vivek V.
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- 2023
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16. Prevalence and significance of DDX41 gene variants in the general population
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Ambrose, J. C., Arumugam, P., Bevers, R., Bleda, M., Boardman-Pretty, F., Boustred, C. R., Brittain, H., Brown, M. A., Caulfield, M. J., Chan, G. C., Giess, A., Griffin, J. N., Hamblin, A., Henderson, S., Hubbard, T. J. P., Jackson, R., Jones, L. J., Kasperaviciute, D., Kayikci, M., Kousathanas, A., Lahnstein, L., Lakey, A., Leigh, S. E. A., Leong, I. U. S., Lopez, F. J., Maleady-Crowe, F., McEntagart, M., Minneci, F., Mitchell, J., Moutsianas, L., Mueller, M., Murugaesu, N., Need, A. C., O‘Donovan, P., Odhams, C. A., Patch, C., Perez-Gil, D., Pereira, M. B., Pullinger, J., Rahim, T., Rendon, A., Rogers, T., Savage, K., Sawant, K., Scott, R. H., Siddiq, A., Sieghart, A., Smith, S. C., Sosinsky, A., Stuckey, A., Tanguy, M., Taylor Tavares, A. L., Thomas, E. R. A., Thompson, S. R., Tucci, A., Welland, M. J., Williams, E., Witkowska, K., Wood, S. M., Zarowiecki, M., Cheloor Kovilakam, Sruthi, Gu, Muxin, Dunn, William G., Marando, Ludovica, Barcena, Clea, Nik-Zainal, Serena, Mohorianu, Irina, Kar, Siddhartha P., Fabre, Margarete A., Quiros, Pedro M., and Vassiliou, George S.
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- 2023
- Full Text
- View/download PDF
17. Adaptive versus conventional cardiac resynchronisation therapy in patients with heart failure (AdaptResponse): a global, prospective, randomised controlled trial
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Wilkoff, Bruce L, Filippatos, Gerasimos, Leclercq, Christophe, Gold, Michael R, Hersi, Ahmad S, Kusano, Kengo, Mullens, Wilfried, Felker, G Michael, Kantipudi, Charan, El-Chami, Mikhael F, Essebag, Vidal, Pierre, Bertrand, Philippon, Francois, Perez-Gil, Francisco, Chung, Eugene S, Sotomonte, Juan, Tung, Stanley, Singh, Balbir, Bozorgnia, Babak, Goel, Satish, Ebert, Hans Holger, Varma, Niraj, Quan, Kara J, Salerno, Fiorella, Gerritse, Bart, van Wel, Janelle, Schaber, Daniel E, Fagan, Dedra H, and Birnie, David
- Published
- 2023
- Full Text
- View/download PDF
18. HNRNPC haploinsufficiency affects alternative splicing of intellectual disability-associated genes and causes a neurodevelopmental disorder
- Author
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Ambrose, J.C., Arumugam, P., Bevers, R., Bleda, M., Boardman-Pretty, F., Boustred, C.R., Brittain, H., Brown, M.A., Caulfield, M.J., Chan, G.C., Giess, A., Griffin, J.N., Hamblin, A., Henderson, S., Hubbard, T.J.P., Jackson, R., Jones, L.J., Kasperaviciute, D., Kayikci, M., Kousathanas, A., Lahnstein, L., Lakey, A., Leigh, S.E.A., Leong, I.U.S., Lopez, F.J., Maleady-Crowe, F., McEntagart, M., Minneci, F., Mitchell, J., Moutsianas, L., Mueller, M., Murugaesu, N., Need, A.C., O‘Donovan, P., Odhams, C.A., Patch, C., Perez-Gil, D., Pereira, M.B., Pullinger, J., Rahim, T., Rendon, A., Rogers, T., Savage, K., Sawant, K., Scott, R.H., Siddiq, A., Sieghart, A., Smith, S.C., Sosinsky, A., Stuckey, A., Tanguy, M., Taylor Tavares, A.L., Thomas, E.R.A., Thompson, S.R., Tucci, A., Welland, M.J., Williams, E., Witkowska, K., Wood, S.M., Zarowiecki, M., Acosta, Maria T., Adams, David R., Alvarez, Raquel L., Alvey, Justin, Allworth, Aimee, Andrews, Ashley, Ashley, Euan A., Afzali, Ben, Bacino, Carlos A., Bademci, Guney, Balasubramanyam, Ashok, Baldridge, Dustin, Bale, Jim, Bamshad, Michael, Barbouth, Deborah, Bayrak-Toydemir, Pinar, Beck, Anita, Beggs, Alan H., Behrens, Edward, Bejerano, Gill, Bellen, Hugo J., Bennet, Jimmy, Bernstein, Jonathan A., Berry, Gerard T., Bican, Anna, Bivona, Stephanie, Blue, Elizabeth, Bohnsack, John, Bonner, Devon, Botto, Lorenzo, Briere, Lauren C., Brown, Gabrielle, Burke, Elizabeth A., Burrage, Lindsay C., Butte, Manish J., Byers, Peter, Byrd, William E., Carey, John, Carrasquillo, Olveen, Cassini, Thomas, Chang, Ta Chen, Chanprasert, Sirisak, Chao, Hsiao-Tuan, Chinn, Ivan, Clark, Gary D., Coakley, Terra R., Cobban, Laurel A., Cogan, Joy D., Coggins, Matthew, Cole, F. Sessions, Colley, Heather A., Cope, Heidi, Corona, Rosario, Craigen, William J., Crouse, Andrew B., Cunningham, Michael, D'Souza, Precilla, Dai, Hongzheng, Dasari, Surendra, Davis, Joie, Dayal, Jyoti G., Delgado, Margaret, Dell'Angelica, Esteban C., Dipple, Katrina, Doherty, Daniel, Dorrani, Naghmeh, Doss, Argenia L., Douine, Emilie D., Earl, Dawn, Eckstein, David J., Emrick, Lisa T., Eng, Christine M., Falk, Marni, Fieg, Elizabeth L., Fisher, Paul G., Fogel, Brent L., Forghani, Irman, Fu, Jiayu, Gahl, William A., Glass, Ian, Goddard, Page C., Godfrey, Rena A., Grajewski, Alana, Halley, Meghan C., Hamid, Rizwan, Hanchard, Neal, Hassey, Kelly, Hayes, Nichole, High, Frances, Hing, Anne, Hisama, Fuki M., Holm, Ingrid A., Hom, Jason, Horike-Pyne, Martha, Huang, Alden, Huang, Yan, Hutchison, Sarah, Introne, Wendy, Isasi, Rosario, Izumi, Kosuke, Jarvik, Gail P., Jarvik, Jeffrey, Jayadev, Suman, Jean-Marie, Orpa, Jobanputra, Vaidehi, Kaitryn, Emerald, Ketkar, Shamika, Kiley, Dana, Kilich, Gonench, Kobren, Shilpa N., Kohane, Isaac S., Kohler, Jennefer N., Korrick, Susan, Krakow, Deborah, Krasnewich, Donna M., Kravets, Elijah, Lalani, Seema R., Lam, Byron, Lam, Christina, Lanpher, Brendan C., Lanza, Ian R., LeBlanc, Kimberly, Lee, Brendan H., Levitt, Roy, Lewis, Richard A., Liu, Pengfei, Liu, Xue Zhong, Longo, Nicola, Loo, Sandra K., Loscalzo, Joseph, Maas, Richard L., Macnamara, Ellen F., MacRae, Calum A., Maduro, Valerie V., Maghiro, AudreyStephannie, Mahoney, Rachel, Malicdan, May Christine, Mamounas, Laura A., Manolio, Teri A., Mao, Rong, Marom, Ronit, Marth, Gabor, Martin, Beth A., Martin, Martin G., Martínez-Agosto, Julian A., Marwaha, Shruti, McCauley, Jacob, McConkie-Rosell, Allyn, McCray, Alexa T., McGee, Elisabeth, Might, Matthew, Miller, Danny, Mirzaa, Ghayda, Morava, Eva, Moretti, Paolo, Morimoto, Marie, Mulvihill, John J., Nakano-Okuno, Mariko, Nelson, Stanley F., Nieves-Rodriguez, Shirley, Novacic, Donna, Oglesbee, Devin, Orengo, James P., Pace, Laura, Pak, Stephen, Pallais, J. Carl, Papp, Jeanette C., Parker, Neil H., Petcharet, Leoyklang, Phillips, John A., III, Posey, Jennifer E., Potocki, Lorraine, Swerdzewski, Barbara N., Quinlan, Aaron, Rao, Deepak A., Raper, Anna, Raskind, Wendy, Renteria, Genecee, Reuter, Chloe, Rives, Lynette, Robertson, Amy K., Rodan, Lance H., Rosenfeld, Jill A., Rosenthal, Elizabeth, Rossignol, Francis, Ruzhnikov, Maura, Sabaii, Marla, Sacco, Ralph, Sampson, Jacinda B., Saporta, Mario, Schaechter, Judy, Schedl, Timothy, Schoch, Kelly, Scott, Daryl A., Seto, Elaine, Sharma, Prashant, Shashi, Vandana, Shelkowitz, Emily, Sheppeard, Sam, Shin, Jimann, Silverman, Edwin, Sinsheimer, Janet, Sisco, Kathy, Smith, Edward, Smith, Kevin, Solnica-Krezel, Lilianna, Solomon, Ben, Spillmann, Rebecca, Stergachis, Andrew, Stoler, Joan, Sullivan, Kathleen, Sullivan, Jennifer, Sutton, Shirley, Sweetser, David A., Sybert, Virginia, Tabor, Holly K., Tan, Queenie K.-G., Tan, Amelia L., Tarakad, Arjun, Tekin, Mustafa, Telischi, Fred, Thorson, Willa, Tifft, Cynthia, Toro, Camilo, Tran, Alyssa A., Ungar, Rachel A., Urv, Tiina K., Vanderver, Adeline, Velinder, Matt, Viskochil, Dave, Vogel, Tiphanie P., Wahl, Colleen E., Walker, Melissa, Walley, Nicole M., Wambach, Jennifer, Wan, Jijun, Wang, Lee-kai, Wangler, Michael F., Ward, Patricia A., Wegner, Daniel, Weisz, Monika, Wener, Mark, Wenger, Tara, Westerfield, Monte, Wheeler, Matthew T., Whitlock, Jordan, Wolfe, Lynne A., Yamamoto, Shinya, Zhang, Zhe, Zuchner, Stephan, Niggl, Eva, Bouman, Arjan, Hoogenboezem, Remco M., Wallaard, Ilse, Park, Joohyun, Admard, Jakob, Wilke, Martina, Harris-Mostert, Emilio D.R.O., Elgersma, Minetta, Bain, Jennifer, Balasubramanian, Meena, Banka, Siddharth, Benke, Paul J., Bertrand, Miriam, Blesson, Alyssa E., Clayton-Smith, Jill, Ellingford, Jamie M., Gillentine, Madelyn A., Goodloe, Dana H., Haack, Tobias B., Jain, Mahim, Krantz, Ian, Luu, Sharon M., McPheron, Molly, Muss, Candace L., Raible, Sarah E., Robin, Nathaniel H., Spiller, Michael, Starling, Susan, Thiffault, Isabelle, Vetrini, Francesco, Witt, Dennis, Woods, Emily, Zhou, Dihong, Elgersma, Ype, and van Esbroeck, Annelot C.M.
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- 2023
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19. Stretch-activated ion channel TMEM63B associates with developmental and epileptic encephalopathies and progressive neurodegeneration
- Author
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Pochiero, Francesca, Mari, Francesco, Ramesh, Venkateswaran, Capra, Valeria, Mancardi, Margherita, Keren, Boris, Mignot, Cyiril, Lulli, Matteo, Parks, Kendall, Griffin, Helen, Brugger, Melanie, Nigro, Vincenzo, Hirata, Yuko, Koichihara, Reiko, Peterlin, Borut, Maki, Ryuto, Nitta, Yohei, Ambrose, John C., Arumugam, Prabhu, Bevers, Roel, Bleda, Marta, Boardman-Pretty, Freya, Boustred, Christopher R., Brittain, Helen, Brown, Matthew A., Caulfield, Mark J., Chan, Georgia C., Giess, Adam, Griffin, John N., Hamblin, Angela, Henderson, Shirley, Hubbard, Tim J.P., Jackson, Rob, Jones, Louise J., Kasperaviciute, Dalia, Kayikci, Melis, Kousathanas, Athanasios, Lahnstein, Lea, Lakey, Anna, Leigh, Sarah E.A., Leong, Ivonne U.S., Lopez, Javier F., Maleady-Crowe, Fiona, McEntagart, Meriel, Minneci, Federico, Mitchell, Jonathan, Moutsianas, Loukas, Mueller, Michael, Murugaesu, Nirupa, Need, Anna C., O’Donovan, Peter, Odhams, Chris A., Patch, Christine, Perez-Gil, Daniel, Pereira, Marina B., Pullinger, John, Rahim, Tahrima, Rendon, Augusto, Rogers, Tim, Savage, Kevin, Sawant, Kushmita, Scott, Richard H., Siddiq, Afshan, Sieghart, Alexander, Smith, Samuel C., Sosinsky, Alona, Stuckey, Alexander, Tanguy, Mélanie, Taylor Tavares, Ana Lisa, Thomas, Ellen R.A., Thompson, Simon R., Tucci, Arianna, Welland, Matthew J., Williams, Eleanor, Witkowska, Katarzyna, Wood, Suzanne M., Zarowiecki, Magdalena, Vetro, Annalisa, Pelorosso, Cristiana, Balestrini, Simona, Masi, Alessio, Hambleton, Sophie, Argilli, Emanuela, Conti, Valerio, Giubbolini, Simone, Barrick, Rebekah, Bergant, Gaber, Writzl, Karin, Bijlsma, Emilia K., Brunet, Theresa, Cacheiro, Pilar, Mei, Davide, Devlin, Anita, Hoffer, Mariëtte J.V., Machol, Keren, Mannaioni, Guido, Sakamoto, Masamune, Menezes, Manoj P., Courtin, Thomas, Sherr, Elliott, Parra, Riccardo, Richardson, Ruth, Roscioli, Tony, Scala, Marcello, von Stülpnagel, Celina, Smedley, Damian, Torella, Annalaura, Tohyama, Jun, Hamada, Keisuke, Ogata, Kazuhiro, Suzuki, Takashi, Sugie, Atsushi, van der Smagt, Jasper J., van Gassen, Koen, Valence, Stephanie, Vittery, Emma, Malone, Stephen, Kato, Mitsuhiro, Matsumoto, Naomichi, Ratto, Gian Michele, and Guerrini, Renzo
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- 2023
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20. Pulmonary surfactant-derived antiviral actions at the respiratory surface
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Isasi-Campillo, Miriam, Losada-Oliva, Paula, Pérez-Gil, Jesús, Olmeda, Bárbara, and García-Ortega, Lucía
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- 2023
- Full Text
- View/download PDF
21. Representaciones orientalistas de España en la literatura popular británica de la segunda mitad del siglo XX
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María del Mar Pérez Gil
- Subjects
Orientalismo ,España ,literatura popular británica ,novelas de amor ,orientalismo feminista ,Language and Literature ,French literature - Italian literature - Spanish literature - Portuguese literature ,PQ1-3999 - Abstract
Este artículo analiza la pervivencia del imaginario orientalista en la literatura popular británica de la segunda mitad del siglo XX ambientada en España. Me centraré en dos novelas donde los elementos orientalistas proyectan la imagen de España como un país exótico, a la vez que menos evolucionado y anclado en el pasado. Además de ello, las autoras emplean la retórica del orientalismo para criticar el carácter prepotente y autoritario de los hombres españoles, herencia, según leemos, de la sangre mora que aún corre por sus venas. Estudiaré cómo este orientalismo feminista se impregna también de prejuicios esencialistas acerca del Otro.
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- 2023
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22. In Memoriam: Sir John Elliot (1930-2022); Encarnación Isla Mingorance (1934-2022); Pedro Navascués Palacio (1942-2022); Cristopher M. S. Johns (1955-2022)
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Fernando Negredo del Cerro, Francisco Manuel Valiñas López, Javier Pérez Gil, and Pilar Díez del Corral Corredoira
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sir john elliot ,encarnación isal mingorance ,pedro navascués palacio ,christopher m. s. johns. ,Arts in general ,NX1-820 ,History of the arts ,NX440-632 ,Visual arts ,N1-9211 - Published
- 2022
23. Véxoa: nós sabemos e a cura indígena da arte brasileira - Entrevista com Naine Terena
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Naine Terena, Gabriela de Carvalho Freire, and Laura Pérez Gil
- Subjects
arte indígena ,museus ,arte e política ,curadoria indígena ,Social history and conditions. Social problems. Social reform ,HN1-995 - Abstract
Nessa entrevista, Naine Terena descreve sua experiência na produção curatorial da exposição de arte indígena Véxoa: nós sabemos, que esteve em cartaz na Pinacoteca de São Paulo entre outubro de 2020 e março de 2021, em plena pandemia de Covid-19. A artista e curadora indígena tece várias reflexões sobre o lugar da Arte Indígena Contemporânea no panorama artístico atual, a invisibilidade histórica das artes indígenas como efeito do processo colonial e as conexões intrínsecas entre arte e política.
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- 2022
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- View/download PDF
24. Insights into the mechanisms of interaction between inhalable lipid-polymer hybrid nanoparticles and pulmonary surfactant
- Author
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Xu, You, Parra-Ortiz, Elisa, Wan, Feng, Cañadas, Olga, Garcia-Alvarez, Begoña, Thakur, Aneesh, Franzyk, Henrik, Pérez-Gil, Jesús, Malmsten, Martin, and Foged, Camilla
- Published
- 2023
- Full Text
- View/download PDF
25. The trade-off between condition and growth shapes juveniles’ survival of harvested demersal fish of the Mediterranean sea
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Karametsidis, Georgios, Rueda, Lucía, Bellido, José M., Esteban, Antonio, García, Encarnación, Gil de Sola, Luís, Pennino, Maria Grazia, Pérez-Gil, José Luís, and Hidalgo, Manuel
- Published
- 2023
- Full Text
- View/download PDF
26. Certain heterozygous variants in the kinase domain of the serine/threonine kinase NEK8 can cause an autosomal dominant form of polycystic kidney disease
- Author
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Ambrose, John C., Arumugam, Prabhu, Bevers, Roel, Bleda, Marta, Boardman-Pretty, Freya, Boustred, Christopher R., Brittain, Helen, Caulfield, Mark J., Chan, Georgia C., Elgar, Greg, Fowler, Tom, Giess, Adam, Hamblin, Angela, Henderson, Shirley, Hubbard, Tim J.P., Jackson, Rob, Jones, Louise J., Kasperaviciute, Dalia, Kayikci, Melis, Kousathanas, Athanasios, Lahnstein, Lea, Leigh, Sarah E.A., Leong, Ivonne U.S., Lopez, Javier F., Maleady-Crowe, Fiona, McEntagart, Meriel, Minneci, Federico, Moutsianas, Loukas, Mueller, Michael, Murugaesu, Nirupa, Need, Anna C., O’Donovan, Peter, Odhams, Chris A., Patch, Christine, Pereira, Mariana Buongermino, Perez-Gil, Daniel, Pullinger, John, Rahim, Tahrima, Rendon, Augusto, Rogers, Tim, Savage, Kevin, Sawant, Kushmita, Scott, Richard H., Siddiq, Afshan, Sieghart, Alexander, Smith, Samuel C., Sosinsky, Alona, Stuckey, Alexander, Tanguy, Mélanie, Taylor Tavares, Ana Lisa, Thomas, Ellen R.A., Thompson, Simon R., Tucci, Arianna, Welland, Matthew J., Williams, Eleanor, Witkowska, Katarzyna, Wood, Suzanne M., Claus, Laura R., Chen, Chuan, Stallworth, Jennifer, Turner, Joshua L., Slaats, Gisela, Hawks, Alexandra L., Mabillard, Holly, Senum, Sarah R., Srikanth, Sujata, Flanagan-Steet, Heather, Louie, Raymond J., Silver, Josh, Lerner-Ellis, Jordan, Morel, Chantal, Mighton, Chloe, Sleutels, Frank, van Slegtenhorst, Marjon, van Ham, Tjakko, Brooks, Alice S., Dorresteijn, Eiske M., Barakat, Tahsin Stefan, Dahan, Karin, Demoulin, Nathalie, Goffin, Eric Jean, Olinger, Eric, Larsen, Martin, Hertz, Jens Michael, Lilien, Marc R., Obeidová, Lena, Seeman, Tomas, Stone, Hillarey K., Kerecuk, Larissa, Gurgu, Mihai, Yousef Yengej, Fjodor A., Ammerlaan, Carola M.E., Rookmaaker, Maarten B., Hanna, Christian, Rogers, R. Curtis, Duran, Karen, Peters, Edith, Sayer, John A., van Haaften, Gijs, Harris, Peter C., Ling, Kun, Mason, Jennifer M., van Eerde, Albertien M., and Steet, Richard
- Published
- 2023
- Full Text
- View/download PDF
27. Comparison of Raw and Torrefied Dichrostachys cinerea as a Fuel for Cogeneration Systems: A Life Cycle Assessment
- Author
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Alba-Reyes, Yasmani, Pérez-Gil, Maylier, Barrera, Ernesto L., Casas-Ledón, Yannay, and Arteaga-Pérez, Luis E.
- Published
- 2022
- Full Text
- View/download PDF
28. A recipe for a good clinical pulmonary surfactant
- Author
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Jesús Pérez-Gil
- Subjects
Surfactant replacement therapy ,Air–liquid interface ,Respiratory distress syndrome ,ARDS ,Lipid–protein interactions ,DPPC ,Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
The lives of thousands premature babies have been saved along the last thirty years thanks to the establishment and consolidation of pulmonary surfactant replacement therapies (SRT). It took some time to close the gap between the identification of the biophysical and molecular causes of the high mortality associated with respiratory distress syndrome in very premature babies and the development of a proper therapy. Closing the gap required the elucidation of some key questions defining the structure–function relationships in surfactant as well as the particular role of the different molecular components assembled into the surfactant system. On the other hand, the application of SRT as part of treatments targeting other devastating respiratory pathologies, in babies and adults, is depending on further extensive research still required before enough amounts of good humanized clinical surfactants will be available. This review summarizes our current concepts on the compositional and structural determinants defining pulmonary surfactant activity, the principles behind the development of efficient natural animal-derived or recombinant or synthetic therapeutic surfactants, as well as a the most promising lines of research that are already opening new perspectives in the application of tailored surfactant therapies to treat important yet unresolved respiratory pathologies.
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- 2022
- Full Text
- View/download PDF
29. Reseña del libro La desaparición de Majorana de Leonardo Sciascia (2007)
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Rodrigo Pérez Gil
- Subjects
reseña de libro ,leonardo sciascia ,literatura ,History of scholarship and learning. The humanities ,AZ20-999 ,Social sciences (General) ,H1-99 - Abstract
«A este narrador siciliano le concierne sobremanera el asunto del poder, de la política, y lo aborda a través de novelas policíacas donde se pone en juego el misterio no develado alrededor de un muerto, ¿asesinato, suicidio o desaparición? Los hechos y los personajes en sus novelas, aun si alguna de ellas aparece con el nombre de “fábula”, suelen tener una referencia histórica. Es el caso de esta novela que reseñamos. De todas maneras, si son casos no resueltos y con cabos sueltos, tal como ocurre con el caso Majorana, la ficción o la imaginación, la especulación o la creencia del autor-narrador no dejan de intervenir. Por eso, aunque basada en hechos reales, La desaparición de Majorana es una novela y no simplemente una obra periodística.»
- Published
- 2022
- Full Text
- View/download PDF
30. Built Ethnological Heritage: from democratization to democracy /Patrimonio etnológico construido: de la democratización a la democracia
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Pérez-Gil, Javier
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- 2022
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31. Airway allergy causes alveolar macrophage death, profound alveolar disorganization and surfactant dysfunction
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Lidia Feo-Lucas, Cristina Godio, María Minguito de la Escalera, Natalia Alvarez-Ladrón, Laura H. Villarrubia, Adrián Vega-Pérez, Leticia González-Cintado, Jorge Domínguez-Andrés, Belén García-Fojeda, Carlos Montero-Fernández, Cristina Casals, Chiara Autilio, Jesús Pérez-Gil, Georgiana Crainiciuc, Andrés Hidalgo, María López-Bravo, and Carlos Ardavín
- Subjects
alveolar macrophages (AM) ,monocytes ,airway allergy inflammation ,allergic asthma ,alveolar dysfunction ,pneumocyte hypertrophy ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Respiratory disorders caused by allergy have been associated to bronchiolar inflammation leading to life-threatening airway narrowing. However, whether airway allergy causes alveolar dysfunction contributing to the pathology of allergic asthma remains unaddressed. To explore whether airway allergy causes alveolar dysfunction that might contribute to the pathology of allergic asthma, alveolar structural and functional alterations were analyzed during house dust mite (HDM)-induced airway allergy in mice, by flow cytometry, light and electron microscopy, monocyte transfer experiments, assessment of intra-alveolarly-located cells, analysis of alveolar macrophage regeneration in Cx3cr1cre:R26-yfp chimeras, analysis of surfactant-associated proteins, and study of lung surfactant biophysical properties by captive bubble surfactometry. Our results demonstrate that HDM-induced airway allergic reactions caused severe alveolar dysfunction, leading to alveolar macrophage death, pneumocyte hypertrophy and surfactant dysfunction. SP-B/C proteins were reduced in allergic lung surfactant, that displayed a reduced efficiency to form surface-active films, increasing the risk of atelectasis. Original alveolar macrophages were replaced by monocyte-derived alveolar macrophages, that persisted at least two months after the resolution of allergy. Monocyte to alveolar macrophage transition occurred through an intermediate stage of pre-alveolar macrophage and was paralleled with translocation into the alveolar space, Siglec-F upregulation, and downregulation of CX3CR1. These data support that the severe respiratory disorders caused by asthmatic reactions not only result from bronchiolar inflammation, but additionally from alveolar dysfunction compromising an efficient gas exchange.
- Published
- 2023
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32. Short-term prognostic factors in Guillain-Barré syndrome: cohort study at the Hospital General de México
- Author
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Franyutti-Prado, Kenia F., primary, Alfaro-Tapia, Claudia E., additional, Chetla-Morales, Diego U., additional, Playas-Pérez, Gil, additional, Escobar-Huerta, Alejandro, additional, Solorza-Ortiz, Emmanuel, additional, Morán-Morales, Milton R., additional, Cruz-Sánchez, Jonatan B., additional, and Carrillo-Mora, Paul, additional
- Published
- 2024
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- View/download PDF
33. Mitochondrial Variation of Bottlenose Dolphins (Tursiops truncatus) from the Canary Islands Suggests a Key Population for Conservation with High Connectivity within the North-East Atlantic Ocean
- Author
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Gómez-Lobo, Daniel A., primary, Monteoliva, Agustín P., additional, Fernandez, Antonio, additional, Arbelo, Manuel, additional, de la Fuente, Jesús, additional, Pérez-Gil, Mónica, additional, Varo-Cruz, Nuria, additional, Servidio, Antonella, additional, Pérez-Gil, Enrique, additional, Borrell, Yaisel J., additional, and Miralles, Laura, additional
- Published
- 2024
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- View/download PDF
34. Deep reinforcement learning based control for Autonomous Vehicles in CARLA.
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óscar Pérez-Gil, Rafael Barea, Elena López Guillén, Luis Miguel Bergasa, Carlos Gómez Huélamo, Rodrigo Gutiérrez, and Alejandro Díaz
- Published
- 2022
- Full Text
- View/download PDF
35. Reflexiones sobre la curaduría decolonial: el caso de 'Nhande Mbya Reko – Nosso jeito de ser guarani'
- Author
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Laura Pérez Gil and Ana Bugnone
- Subjects
Museo ,Mbya Guaraní ,Curaduría colaborativa ,Decolonialidad ,Latin America. Spanish America ,F1201-3799 ,Social Sciences - Abstract
Resumen En este artículo se describe y analiza la exposición “Nhande Mbya Reko – Nosso jeito de ser guarani”, llevada a cabo en el Museu de Arqueologia e Etnologia de la Universidade Federal do Paraná (Brasil) en 2018, y se realizan una serie reflexiones teóricas y propositivas acerca de la necesidad de transformar la cultura institucional y técnica en los museos según una perspectiva decolonial. Con una metodología cualitativa, se recolectó información proveniente del proceso de curaduría colaborativa entre personal del museo y miembros de las comunidades mbya guaraní, que incluyó registros de reuniones, entrevistas, fotografías y materiales gráficos. Asimismo, los textos teóricos que ofrecen la base del análisis y las reflexiones provienen de las museologías crítica y social, los estudios decoloniales, la antropología y la sociología. Los resultados de la investigación indican que la exposición se destacó por el carácter polifónico y dialógico, ya que la curaduría colaborativa implicó la necesidad de llevar adelante debates y acuerdos entre las personas intervinientes. Por otro lado, se señala la necesidad de indagar sobre las prácticas museales y sus relaciones con las comunidades participantes, los públicos y la sociedad en general.
- Published
- 2023
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- View/download PDF
36. El posicionamiento de la agencia EFE en las redes sociales
- Author
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Fernando Peinado Miguel and Carlos Pérez Gil
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Agencia EFE ,redes sociales ,agencias de noticias ,verificación ,multimedia ,Communication. Mass media ,P87-96 ,Journalism. The periodical press, etc. ,PN4699-5650 - Abstract
Las redes sociales han supuesto un factor clave en el cambio de paradigma experimentado en el consumo, divulgación y elaboración de contenidos informativos y han motivado a los medios de comunicación a adaptarse a este nuevo escenario para no quedar desplazados. La Agencia EFE, como otras grandes agencias de noticias, se ha visto obligada a adaptarse al nuevo contexto y adentrarse en las plataformas sociales para reafirmar su rol de proveedora de contenidos, dinamizar sus informaciones y potenciar el valor de su marca. Aunque EFE no ha logrado que su inmersión en las redes se traduzca en una vía alternativa de obtención de ingresos, su presencia en ellas y la visibilidad que le otorgan representan una pasarela para atraer a nuevos clientes. También para entablar formas de colaboración que refuerzan su nuevo papel como verificador de noticias frente a la propagación de bulos que permean en las redes sociales.
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- 2023
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37. Leptospirosis genital incidental en machos Bubalus bubalis del estado Portuguesa, Venezuela
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Rosaura Pérez-Gil and Sergio Rivera-Pirela
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Leptospira hebdomadis ,MAT ,anomalías espermáticas ,histopatología ,bacteriología ,Bubalus bubalis ,Cattle ,SF191-275 ,Veterinary medicine ,SF600-1100 - Abstract
La leptospirosis constituye una importante causa de infertilidad en bóvidos. En Bubalus bubalis, Leptospira spp. infecta el tejido renal, así como los órganos sexuales, por lo que puede excretarse, tanto en orina como en semen. Solo un número limitado de estudios en todo el mundo han investigado la seroprevalencia de la enfermedad en machos bovinos y los riesgos reproductivos relacionados con la eliminación del patógeno en el semen. Se reportan aquí los resultados de la evaluación serológica, microbiológica, seminal e histopatológica de machos bufalinos adultos del municipio Esteller, estado Portuguesa, Venezuela, infectados naturalmente con Leptospira spp. Se evaluaron 17 búfalos mestizos Murrah de 40 meses de edad, previo al beneficio, con 500 kilos de peso promedio, no vacunados, a los cuales se les tomaron muestra de suero sanguíneo, orina, semen y se midió circunferencia escrotal junto a otros parámetros reproductivos. Exclusivamente 15 animales mostraron títulos entre 50 y 200 en la MAT, exclusivamente para L. hebdomadis. Los 2 animales negativos a MAT resultaron positivos en cultivo bacteriológico de orina o semen a Leptospira spp. De 6 animales beneficiados, MAT y bacteriológicamente positivos a leptospira en semen y orina, se extrajeron riñones, testículos y epidídimos para examen histopatológico. De epidídimos y riñónes se aislaron Leptospira spp., no así de testículos. Sin embargo, el diagnóstico histopatológico en testículo y epidídimo indicó degeneración de células seminíferas compatible con infección bacteriana. El riñón presentó nefritis intersticial crónica. Hubo disminución en el promedio de la circunferencia escrotal, baja intención de monta, baja concentración espermática, ausencia de ondas, pocos espermatozoides móviles, baja motilidad espermática y más de 30 % de mortalidad espermática de las muestras de semen evaluadas, indicando baja calidad del eyaculado. Las anomalías seminales mayores y menores superaron las escalas recomendadas para la especie. Se reportan aquí resultados exclusivos de búfalos machos infectados individualmente con L. hebdomadis, excretada por orina y semen, responsable de afectar el tracto reproductivo de manera incidental, ocasionando daños espermáticos, del epidídimo y daño renal, en una explotación mixta arrocera, con presencia de roedores, potenciales transmisores de la leptospirosis.
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- 2023
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38. Origin and driving mechanisms of marine litter in the shelf-incised Motril, Carchuna, and Calahonda canyons (northern Alboran Sea)
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Javier Cerrillo-Escoriza, Francisco José Lobo, Ángel Puga-Bernabéu, José Luis Rueda, Patricia Bárcenas, Olga Sánchez-Guillamón, José Miguel Serna Quintero, José Luis Pérez Gil, Yelvana Murillo, José Antonio Caballero-Herrera, Adrián López-Quirós, Isabel Mendes, and José Noel Pérez-Asensio
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submarine canyons ,marine litter ,seafloor imagery ,litter hotspots ,marine litter-habitats interaction ,fishing gear ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
Introduction and methodsMarine litter density, distribution and potential sources, and the impact on canyon seafloor habitats were investigated in the Motril, Carchuna and Calahonda canyons, located along the northern margin of the Alboran Sea. During the ALSSOMAR-S2S oceanographic survey carried out in 2019, canyon floor imagery was collected by a Remotely Operated Vehicle along 5 km in the Motril Canyon, 10 km in the Carchuna Canyon, and 3 km in Calahonda Canyon, together with 41 surficial sediment samples. Additionally, coastal uses, maritime traffic and fishing activity data were analyzed. A 50 m resolution multibeam bathymetry served as base map.ResultsIn the Motril and Calahonda canyons, the density of marine litter was low and the material was dispersed, very degraded and partially buried. In contrast, the Carchuna Canyon contained a greater amount and variety of litter. The Carchuna Canyon thalweg exhibited a density of marine litter up to 8.66 items·100 m-1, and litter hotspots with a density of up to 42 items·m2 are found along the upper reaches of the canyon thalweg.DiscussionLow litter abundances found in the studied canyons most likely reflect low population densities and the absence of direct connections with streams in the nearby coasts. The high shelf incision of the Carchuna Canyon and its proximity to the coastline favor littoral sediment remobilization and capture as well as the formation of gravity flows that transport the marine litter along the thalweg toward the distal termination of the channel. Litter hotspots are favored by the canyon morphology and the occurrence of rocky outcrops. Most debris is of coastal origin and related to beach occupation and agricultural practices in the adjacent coastal plain. A third origin was represented by fishing gear in the study area. Fishing activity may be producing an impact through physical damage to the skeletons of the colonial scleractinians located in the walls of the Carchuna Canyon. In contrast, the Motril and Calahonda canyons can be considered passive systems that have mainly acted as depositional sinks in the recent past, as evidenced by buried marine litter.
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- 2023
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39. Identification of 4 novel human ocular coloboma genes ANK3, BMPR1B, PDGFRA, and CDH4 through evolutionary conserved vertebrate gene analysis
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Ambrose, J.C., Baple, E.L., Bleda, M., Boardman-Pretty, F., Boissiere, J.M., Boustred, C.R., Caulfield, M.J., Chan, G.C., Craig, C.E.H., Daugherty, L.C., de, Burca A., Devereau, A., Elgar, G., Foulger, R.E., Fowler, T., Furió-Tarí, P., Hackett, J.M., Halai, D., Holman, J.E., Hubbard, T.J.P., Jackson, R., Kasperaviciute, D., Kayikci, M., Lahnstein, L., Lawson, K., Leigh, S.E.A., Leong, I.U.S., Lopez, F.J., Maleady-Crowe, F., Mason, J., McDonagh, E.M., Moutsianas, L., Mueller, M., Murugaesu, N., Need, A.C., Odhams, C.A., Patch, C., Perez-Gil, D., Polychronopoulos, D., Pullinger, J., Rahim, T., Rendon, A., Riesgo-Ferreiro, P., Rogers, T., Ryten, M., Savage, K., Sawant, K., Scott, R.H., Siddiq, A., Sieghart, A., Smedley, D., Smith, K.R., Sosinsky, A., Spooner, W., Stevens, H.E., Stuckey, A., Sultana, R., Thomas, E.R.A., Thompson, S.R., Tregidgo, C., Tucci, A., Walsh, E., Watters, S.A., Welland, M.J., Williams, E., Witkowska, K., Wood, S.M., Zarowiecki, M., Owen, Nicholas, Toms, Maria, Young, Rodrigo M., Eintracht, Jonathan, Sarkar, Hajrah, Brooks, Brian P., and Moosajee, Mariya
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- 2022
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40. Deep reinforcement learning based control for Autonomous Vehicles in CARLA
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Pérez-Gil, Óscar, Barea, Rafael, López-Guillén, Elena, Bergasa, Luis M., Gómez-Huélamo, Carlos, Gutiérrez, Rodrigo, and Díaz-Díaz, Alejandro
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- 2022
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41. Deep Reinforcement Learning based control algorithms: Training and validation using the ROS Framework in CARLA Simulator for Self-Driving applications.
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óscar Pérez-Gil, Rafael Barea, Elena López Guillén, Luis Miguel Bergasa, Carlos Gómez Huélamo, Rodrigo Gutiérrez, and Alejandro Díaz
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- 2021
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42. Integrating OpenFace 2.0 Toolkit for Driver Attention Estimation in Challenging Accidental Scenarios
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Araluce, Javier, Bergasa, Luis M., Gómez-Huélamo, Carlos, Barea, Rafael, López-Guillén, Elena, Arango, Felipe, Pérez-Gil, Óscar, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Bergasa, Luis M., editor, Ocaña, Manuel, editor, Barea, Rafael, editor, López-Guillén, Elena, editor, and Revenga, Pedro, editor
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- 2021
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43. DQN-Based Deep Reinforcement Learning for Autonomous Driving
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Pérez-Gil, Óscar, Barea, Rafael, López-Guillén, Elena, Bergasa, Luis M., Revenga, Pedro A., Gutiérrez, Rodrigo, Díaz, Alejandro, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Bergasa, Luis M., editor, Ocaña, Manuel, editor, Barea, Rafael, editor, López-Guillén, Elena, editor, and Revenga, Pedro, editor
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- 2021
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44. The Blackspot Seabream Fishery in the Strait of Gibraltar: Lessons and Future Perspectives of Shared Marine Resource
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Gil-Herrera, Juan, Gutiérrez-Estrada, Juan Carlos, Benchoucha, Said, Pérez-Gil, José Luis, Sanz-Fernández, Víctor, el Arraf, Sana, Burgos, Candelaria, Malouli Idrissi, Mohammed, Farias, Carlos, Báez, José Carlos, editor, Vázquez, Juan-Tomás, editor, Camiñas, Juan Antonio, editor, and Malouli Idrissi, Mohammed, editor
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- 2021
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45. Effectiveness, survival and safety of guselkumab attending to basal characteristics in moderate-to-severe psoriatic patients: a cohort study [version 2; peer review: 2 approved]
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Ricardo Ruiz-Villaverde, Lourdes Rodriguez-Fernandez-Freire, Jose C. Armario-Hita, Amalia Pérez-Gil, Fiorella Vasquez Chinchay, and Manuel Galán-Gutiérrez
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Clinical Practice Article ,Articles ,Guselkumab ,Psoriasis ,Effectiveness ,Survival ,Safety ,Demographic characteristics - Abstract
Background: Psoriasis is a chronic inflammatory disease which can impact quality of life. In the past decade multiple biologic treatments have been released with encouraging results. Guselkumab is a monoclonal antibody targeting IL-23p19. Multiple randomized clinical trials have demonstrated its efficacy in psoriasis, but response differences among patient subpopulations have not been extensively reported. Furthermore, patients in real life are often non-eligible for clinical trials and their responses may differ from pivotal studies. Methods: This is a retrospective, observational study of real clinical practice of patients receiving guselkumab treatment in Spain. Patients treated with guselkumab were included between February 2019 to December 2021. This study evaluates the potential differential effect of baseline demographic and disease characteristics on therapeutic responses to guselkumab. We measured effectiveness and survival by the psoriasis area and severity index, the dermatology life quality index as well as Kaplan meier curves, respectively. Categorical and quantitative variables are reported with frequencies, and with mean and standard deviation, respectively. Differences between groups in psoriasis area and severity index and dermatology life quality index, were calculated using a mixed-effects analysis. Survival was calculated using Kaplan meier curves and log-rank tests. Results: A total of 87 patients were included. In this study, our objective was to evaluate the effectiveness, safety and survival of guselkumab attending to demographic characteristics. No differences in psoriasis area and severity index or dermatology life quality index baseline values or therapeutic responses were noted at 52 weeks of follow-up among all the subgroups analysed (age, sex, psoriasis duration, body mass index, and comorbidities). A difference in drug survival was only seen between gender groups. Conclusions: Our research has demonstrated the consistency of guselkumab effectiveness across patient subgroups. No baseline features affected the effectiveness or drug survival of guselkumab, except for lower drug survival in female patients.
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- 2022
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46. Effectiveness, survival and safety of guselkumab attending to basal characteristics in moderate-to-severe psoriatic patients: a cohort study [version 1; peer review: 1 approved with reservations]
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Ricardo Ruiz-Villaverde, Lourdes Rodriguez-Fernandez-Freire, Jose C. Armario-Hita, Amalia Pérez-Gil, Fiorella Vasquez Chinchay, and Manuel Galán-Gutiérrez
- Subjects
Clinical Practice Article ,Articles ,Guselkumab ,Psoriasis ,Effectiveness ,Survival ,Safety ,Demographic characteristics - Abstract
Background: Psoriasis is a chronic inflammatory disease which can impact quality of life. In the past decade multiple biologic treatments have been released with encouraging results. Guselkumab is a monoclonal antibody targeting IL-23p19. Multiple randomized clinical trials have demonstrated its efficacy in psoriasis, but response differences among patient subpopulations have not been extensively reported. Furthermore, patients in real life are often non-eligible for clinical trials and their responses may differ from pivotal studies. Methods: This is a retrospective, observational study of real clinical practice of patients receiving guselkumab treatment in Spain. Patients treated with guselkumab were included between February 2019 to December 2021. This study evaluates the potential differential effect of baseline demographic and disease characteristics on therapeutic responses to guselkumab. We measured effectiveness and survival by the psoriasis area and severity index, the dermatology life quality index as well as Kaplan meier curves, respectively. Categorical and quantitative variables are reported with frequencies, and with mean and standard deviation, respectively. Differences between groups in psoriasis area and severity index and dermatology life quality index, were calculated using a mixed-effects analysis. Survival was calculated using Kaplan meier curves and log-rank tests. Results: A total of 87 patients were included. In this study, our objective was to evaluate the effectiveness, safety and survival of guselkumab attending to demographic characteristics. No differences in psoriasis area and severity index or dermatology life quality index baseline values or therapeutic responses were noted at 52 weeks of follow-up among all the subgroups analysed (age, sex, psoriasis duration, body mass index, and comorbidities). A difference in drug survival was only seen between gender groups. Conclusions: Our research has demonstrated the consistency of guselkumab effectiveness across patient subgroups. No baseline features affected the effectiveness or drug survival of guselkumab, except for lower drug survival in female patients.
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- 2022
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47. Whole genome sequencing for the diagnosis of neurological repeat expansion disorders in the UK: a retrospective diagnostic accuracy and prospective clinical validation study
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McDonagh, Ellen M, Rueda, Antonio, Polychronopoulos, Dimitris, Chan, Georgia, Angus-Leppan, Heather, Bhatia, Kailash P, Davison, James E, Festenstein, Richard, Fratta, Pietro, Giunti, Paola, Howard, Robin, Venkata, Laxmi, Laurá, Matilde, McEntagart, Meriel, Menzies, Lara, Morris, Huw, Reilly, Mary M, Robinson, Robert, Rosser, Elisabeth, Faravelli, Francesca, Schrag, Anette, Schott, Jonathan M, Warner, Thomas T, Wood, Nicholas W, Bourn, David, Eggleton, Kelly, Labrum, Robyn, Twiss, Philip, Abbs, Stephen, Santos, Liana, Almheiri, Ghareesa, Sheikh, Isabella, Vandrovcova, Jana, Patch, Christine, Taylor Tavares, Ana Lisa, Hyder, Zerin, Need, Anna, Brittain, Helen, Baple, Emma, Moutsianas, Loukas, Deshpande, Viraj, Perry, Denise L, Ajay, Subramanian S., Chawla, Aditi, Rajan, Vani, Oprych, Kathryn, Chinnery, Patrick F, Douglas, Angela, Wilson, Gill, Ellard, Sian, Temple, I Karen, Mumford, Andrew, McMullan, Dom, Naresh, Kikkeri, Flinter, Frances A, Taylor, Jenny C, Greenhalgh, Lynn, Newman, William, Brennan, Paul, Sayer, John A, Raymond, F Lucy, Chitty, Lyn S, Ambrose, John C., Arumugam, Prabhu, Bleda, Marta, Boardman-Pretty, Freya, Boissiere, Jeanne M., Boustred, Christopher R., Craig, Clare E.H., de Burca, Anna, Devereau, Andrew, Elgar, Greg, Foulger, Rebecca E., Furió-Tarí, Pedro, Hackett, Joanne, Halai, Dina, Hamblin, Angela, Henderson, Shirley, Holman, James, Hubbard, Tim J.P., Jackson, Rob, Jones, Louise J., Kayikci, Melis, Lahnstein, Lea, Lawson, Kay, Leigh, Sarah E.A., Leong, Ivonne U.S., Lopez, Javier F., Maleady-Crowe, Fiona, Mason, Joanne, Mueller, Michael, Murugaesu, Nirupa, Odhams, Chris A., Perez-Gil, Daniel, Pullinger, John, Rahim, Tahrima, Riesgo-Ferreiro, Pablo, Rogers, Tim, Ryten, Mina, Savage, Kevin, Sawant, Kushmita, Siddiq, Afshan, Sieghart, Alexander, Smedley, Damian, Sosinsky, Alona, Spooner, William, Stevens, Helen E., Stuckey, Alexander, Sultana, Razvan, Thompson, Simon R., Tregidgo, Carolyn, Walsh, Emma, Watters, Sarah A., Welland, Matthew J., Williams, Eleanor, Witkowska, Katarzyna, Wood, Suzanne M., Zarowiecki, Magdalena, Ibañez, Kristina, Polke, James, Hagelstrom, R Tanner, Dolzhenko, Egor, Pasko, Dorota, Thomas, Ellen Rachel Amy, Daugherty, Louise C, Kasperaviciute, Dalia, Smith, Katherine R, Deans, Zandra C, Hill, Sue, Fowler, Tom, Scott, Richard H, Hardy, John, Houlden, Henry, Rendon, Augusto, Caulfield, Mark J, Eberle, Michael A, Taft, Ryan J, and Tucci, Arianna
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- 2022
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48. Early clinical effect of cladribine in patients with highly active multiple sclerosis in Mexico.
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Sauri-Suarez, Sergio, Quiñones, Sandra, De la Maza-Flores, Manuel, Marin-Contreras, Arturo, Playas-Pérez, Gil, Bertado-Cortes, Brenda, Frias-Marquez, Francisco, Zuñiga-García, Gilberto, Rodriguez-Leal, Francisco, Blaisdell-Vidal, Carlos, and Gomez-Figueroa, Enrique
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MEXICANS ,MULTIPLE sclerosis ,SUCCESSFUL people ,COHORT analysis ,MAGNETIC resonance imaging - Abstract
Background: Cladribine shows efficacy in multiple sclerosis (MS), but Latin American (LATAM) real-world data is limited, despite potential sociodemographic variations. Objective: Investigate baseline characteristics and clinical response in highly active MS patients in Mexico, identifying predictors of early treatment response. Method: A multicenter cohort study analyzed retrospective data from individuals with "highly active" MS in the Cladribine Patient Support Program across 11 Mexican clinics. Criteria included one-year prior treatment with another disease-modifying treatment and recent relapse with specific MRI findings. Primary outcomes focused on achieving NEDA-3 status after 12 months. Results: In the follow-up, 67.5% maintained NEDA-3 status. Baseline EDSS scores decreased significantly from 1.50 to 1.00 (p = 0.011), with no confirmed disability worsening. No significant differences were observed between NEDA-3 achievers and non-achievers in demographic and clinical variables. No severe adverse events were reported. Conclusion: Cladribine showed early and effective control of active MS in Mexican patients, demonstrating a secure profile with minimal adverse events. This study provides valuable real-world evidence in the LATAM context. [ABSTRACT FROM AUTHOR]
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- 2024
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49. PRESENCIA DE LA TECNOLOG?A DE VEH?CULOS A?REOS NO TRIPULADOS EN LOS DOMINIOS DE INVESTIGACI?'N EN CIENCIAS DE LA SUSTENTABILIDAD/PRESENCE OF UNMANNED AERIAL VEHICLES TECHNOLOGY IN THE RESEARCH DOMAINS OF SUSTAINABILITY SCIENCES/PRESEN?A DA TECNOLOGIA DE VE?CULOS A?REOS N?O TRIPULADOS NOS DOM?NIOS DE PESQUISA EM CI?NCIAS DA SUSTENTABILIDADE
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Núñez, Juan Manuel, Suarez, Ana Penella, Rodríguez, Regina Pérez-Gil, Maurer, Inés Costes, Gallardo-Cruz, José Alberto, and Mora, Daniel Alejandro Pérez De La
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- 2022
50. Interacciones lípido-proteína y proteínalípido: contextos e interfases que definen funciones críticas
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Pérez Gil, Jesús, primary
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- 2023
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