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14. The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth

Author

Sandovici, Ionel, primary, Georgopoulou, Aikaterini, additional, Pérez-García, Vicente, additional, Hufnagel, Antonia, additional, López-Tello, Jorge, additional, Lam, Brian Y.H., additional, Schiefer, Samira N., additional, Gaudreau, Chelsea, additional, Santos, Fátima, additional, Hoelle, Katharina, additional, Yeo, Giles S.H., additional, Burling, Keith, additional, Reiterer, Moritz, additional, Fowden, Abigail L., additional, Burton, Graham J., additional, Branco, Cristina M., additional, Sferruzzi-Perri, Amanda N., additional, and Constância, Miguel, additional

Published
2022
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15. Experimental energy performance evaluation in a commercial freezer using R1234yf at different thermal load levels

Author

Pérez García, Vicente, Méndez Méndez, Darío, and Guzmán Guerrero, Óscar Adrián

Subjects
R134a, Climate change, Cambio climático, Carga térmica, Thermal steady, Mudança climática, Estabilização térmica, Thermal load, Estabilización térmica, COP, R1234yf
Abstract

The use of low GWP refrigerants has been extended around of world due to new environmental policies in the last decade. In this sense, commercial refrigerants that are replacing R134a have a principal characteristic of a low global warming potential (GWP). This paper presents an experimental study of energy performance on a commercial freezer using R1234yf as a replacement to R134a considering three thermal load conditions: without thermal load, medium load thermal load, and full thermal load. Results showed that the use of R1234yf promotes a reduction in the internal temperature on the freezer which is 2.3% lowest cold R134a, while the steady thermal time gets with R134a is lower than R1234yf in 11.1%, 11.7%, and 4.4% respectively for each thermal load level. El uso de refrigerantes bajo GWP se ha extendido cada vez más a nivel mundial debido a las nuevas políticas ambientales que han surgido en la última década. En este contexto, los refrigerantes comerciales que están desplazando al actual R134a, son aquellos que presentan bajo potencial de calentamiento global (GWP) en comparación con el mencionado anteriormente. En este trabajo se presenta el estudio experimental del desempeño energético de un congelador comercial utilizando el refrigerante R1234yf como sustituto al R134a a tres condiciones de carga térmica: sin carga, media carga y carga completa. Los resultados muestran que, con el uso del R1234yf, la temperatura en el interior del congelador es 2.3% más fría que con el R134a, mientras que el tiempo de estabilización térmica de alcanzado con el R134a es menor al alcanzado por el R1234yf en un 11.1%, 11.7% y 4.4% para cada nivel de carga térmica, respectivamente. O uso de refrigerantes de baixo PAG foi estendido ao redor do mundo devido a novas políticas ambientais na última década. Nesse sentido, os refrigerantes comerciais que estão substituindo o R134a têm como principal característica o baixo potencial de aquecimento global (GWP). Este trabalho apresenta um estudo experimental de desempenho energético em um freezer comercial usando R1234yf em substituição ao R134a considerando três condições de carga térmica: sem carga térmica, carga térmica média e carga térmica total. Os resultados mostraram que o uso de R1234yf promove uma redução na temperatura interna do freezer, que é 2,3% mais baixa fria R134a, enquanto o tempo térmico constante com R134a é inferior a R1234yf em 11,1%, 11,7% e 4,4% respectivamente para cada nível de carga térmica.

Published
2021

17. Comparación del Desempeño Térmico-Hidráulico de Dos Colectores Solares de Placa Plana con Diferentes Geometrías Mediante la Dinámica de Fluidos Computacional.

Author

Ramírez Minguela, José de Jesús, Sillero López, Paulina, Alfaro Ayala, Jorge Arturo, Pérez García, Vicente, Rodríguez Muñoz, José Luis, Pérez Segura, Tzayam, and Alvarado Rodríguez, Carlos Enrique

Abstract

Copyright of Congreso Internacional de Investigacion Academia Journals is the property of PDHTech, LLC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

18. Reconversión de Máquina Ponedora a Modelo Hidráulico e Interfaz de Control Hombre-Máquina.

Author

Solorio Alvarado, Angel Isaac, Pérez García, Vicente, Zaleta Aguilar, Alejandro, and Ortega Contreras, Jorge Andrés

Abstract

Copyright of Congreso Internacional de Investigacion Academia Journals is the property of PDHTech, LLC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021

20. A promoter DNA demethylation landscape of human hematopoietic differentiation

Author

Calvanese, Vincenzo, Fernández, Agustín F., Urdinguio, Rocío G., Suárez-Alvarez, Beatriz, Mangas, Cristina, Pérez-García, Vicente, Bueno, Clara, Montes, Rosa, Ramos-Mejía, Verónica, Martínez-Camblor, Pablo, Ferrero, Cecilia, Assenov, Yassen, Bock, Christoph, Menendez, Pablo, Carrera, Ana Clara, Lopez-Larrea, Carlos, and Fraga, Mario F.

Published
2012
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21. INFLUENCIA DE LAS FUNCIONES DE MEMBRESÍA DE UN CONTROLADOR DIFUSO IMPLEMENTADO EN UN REFRIGERADOR DOMÉSTICO.

Author

Rodríguez Valderrama, David Alejandro, Pardo Cely, Diana, Heredia Aricapa, Yonathan, Belman Flores, Juan Manuel, and Pérez García, Vicente

Abstract

Copyright of Congreso Internacional de Investigacion Academia Journals is the property of PDHTech, LLC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020

22. Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice

Author

López-Tello, Jorge, primary, Pérez-García, Vicente, additional, Khaira, Jaspreet, additional, Kusinski, Laura C, additional, Cooper, Wendy N, additional, Andreani, Adam, additional, Grant, Imogen, additional, Fernández de Liger, Edurne, additional, Lam, Brian YH, additional, Hemberger, Myriam, additional, Sandovici, Ionel, additional, Constancia, Miguel, additional, and Sferruzzi-Perri, Amanda N, additional

Published
2019
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23. Author response: Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice

Author

López-Tello, Jorge, primary, Pérez-García, Vicente, additional, Khaira, Jaspreet, additional, Kusinski, Laura C, additional, Cooper, Wendy N, additional, Andreani, Adam, additional, Grant, Imogen, additional, Fernández de Liger, Edurne, additional, Lam, Brian YH, additional, Hemberger, Myriam, additional, Sandovici, Ionel, additional, Constancia, Miguel, additional, and Sferruzzi-Perri, Amanda N, additional

Published
2019
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25. The Imprinted Igf2-Igf2r Axis is Critical for Matching Placental Microvasculature Expansion to Fetal Growth

Author

Sandovici, Ionel, primary, Georgopoulou, Aikaterini, additional, Pérez-García, Vicente, additional, Hufnagel, Antonia, additional, López-Tello, Jorge, additional, Lam, Brian Y.H., additional, Schiefer, Samira N., additional, Gaudreau, Chelsea, additional, Santos, Fátima, additional, Hoelle, Katharina, additional, Yeo, Giles S.H., additional, Burling, Keith, additional, Reiterer, Moritz, additional, Fowden, Abigail L., additional, Burton, Graham J., additional, Branco, Cristina M., additional, Sferruzzi-Perri, Amanda N., additional, and Constância, Miguel, additional

Published
2019
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28. Efecto del intercambiador de gas sobre el rendimiento energético de un sistema de refrigeración difusión-absorción.

Author

Rodríguez Muñoz, José Luis, Pérez García, Vicente, Belman Flores, Juan Manuel, and Rodrígue, Ismael Regalado

Abstract

Copyright of Congreso Internacional de Investigacion Academia Journals is the property of PDHTech, LLC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018

29. Herramienta para el monitoreo de variables energéticas en una nevera comercial.

Author

García Cisneros, Juan Manuel, Pérez García, Vicente, Pérez Yata, Juan Carlos, and Belman Flores, Juan Manuel

Abstract

Copyright of Congreso Internacional de Investigacion Academia Journals is the property of PDHTech, LLC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018

30. Papel de la oligomerización de las PI3K de Clase IA p110α y p110β en la regulación de la actividad de PTEN

Author

Pérez García, Vicente, Carrera Ramírez, Ana Clara, UAM. Departamento de Biología Molecular, and CSIC. Centro Nacional de Biotecnología (CNB)

Subjects
Proteínas de supresión tumoral - Tesis doctorales, Biología y Biomedicina / Biología
Abstract

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de lectura: 16-07-2014, One of the central pathways that enhances cell survival, division and migration, and is frequently deregulated in cancer is that of PI3K/PTEN (phosphoinositide 3- -kinase/phosphatase and tensin homolog). Although four genes encode PI3K p110 catalytic subunits and there are seven regulatory subunits, only the p110α and p110β isoforms and the p85 regulatory subunits are expressed ubiquitously in body tissues. When cells are activated to enter the cell cycle, the PI3K catalyze formation of the phosphatidylinositol (PI)(3,4,5)P3, a second messenger that triggers a number of important signaling cascades; PTEN subsequently reduces PI(3,4,5)P3 to basal levels. Activation of p110α precedes that of p110β at several points in the cell cycle, during G0/G1 and G1/S transitions and at mitosis entry; nonetheless, it is not known whether p110α and p110β activation are linked. In addition, PI3K activation precedes that of PTEN, but its ability to regulate PTEN activation has not been studied. We explored the potential connections between p110α, p110β and PTEN activation, and found that serum stimulation of cells promotes p110α and p110β association, which demonstrates oligomerization of PI3K catalytic subunits within the cells. Moreover, p110α regulates optimal p110β activation by direct association of the two isoforms. p85 dimerization through N-terminal SH3-BcR domains is necessary for p110α/p110β complex formation. PTEN is also incorporated into the p110α/p110β complex, and its activation depends on its association to this oligomer. Our results show that PI3K and PTEN activities regulate one other within a multimolecular complex that controls cell PI(3,4,5)P3 levels.

Published
2014

31. Extraction and analysis of signatures from the Gene Expression Omnibus by the crowd

Author

Wang, Zichen, primary, Monteiro, Caroline D., additional, Jagodnik, Kathleen M., additional, Fernandez, Nicolas F., additional, Gundersen, Gregory W., additional, Rouillard, Andrew D., additional, Jenkins, Sherry L., additional, Feldmann, Axel S., additional, Hu, Kevin S., additional, McDermott, Michael G., additional, Duan, Qiaonan, additional, Clark, Neil R., additional, Jones, Matthew R., additional, Kou, Yan, additional, Goff, Troy, additional, Woodland, Holly, additional, Amaral, Fabio M R., additional, Szeto, Gregory L., additional, Fuchs, Oliver, additional, Schüssler-Fiorenza Rose, Sophia M., additional, Sharma, Shvetank, additional, Schwartz, Uwe, additional, Bausela, Xabier Bengoetxea, additional, Szymkiewicz, Maciej, additional, Maroulis, Vasileios, additional, Salykin, Anton, additional, Barra, Carolina M., additional, Kruth, Candice D., additional, Bongio, Nicholas J., additional, Mathur, Vaibhav, additional, Todoric, Radmila D, additional, Rubin, Udi E., additional, Malatras, Apostolos, additional, Fulp, Carl T., additional, Galindo, John A., additional, Motiejunaite, Ruta, additional, Jüschke, Christoph, additional, Dishuck, Philip C., additional, Lahl, Katharina, additional, Jafari, Mohieddin, additional, Aibar, Sara, additional, Zaravinos, Apostolos, additional, Steenhuizen, Linda H., additional, Allison, Lindsey R., additional, Gamallo, Pablo, additional, de Andres Segura, Fernando, additional, Dae Devlin, Tyler, additional, Pérez-García, Vicente, additional, and Ma’ayan, Avi, additional

Published
2016
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33. ANÁLISIS DEL USO DE UNA IMPRESORA 3D EN LA REALIZACIÓN DE PRÓTESIS DENTALES.

Author

Quiroz García, Sandra, de Jesús Ramírez Minguela, José, Alfaro Ayala, Jorge Arturo, and Pérez García, Vicente

Abstract

Copyright of Congreso Internacional de Investigacion Academia Journals is the property of PDHTech, LLC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017

35. Análisis numérico de una celda de combustible de membrana de intercambio de protones considerando una geometría plana.

Author

Ramírez Minguela, José de Jesús, Alfaro Ayala, Jorge Arturo, Rodríguez Muñoz, José Luis, Pérez García, Vicente, and Mendoza Miranda, Juan Manuel

Abstract

Copyright of Congreso Internacional de Investigacion Academia Journals is the property of PDHTech, LLC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2015

36. Transient behavior of CO 2 in the internal heat exchanger during the start-up of the transcritical refrigeration system.

Author

Ituna-Yudonago, Jean F., Belman-Flores, Juan Manuel, Elizalde-Blancas, Francisco, Serrano-Arellano, Juan, Pérez-García, Vicente, and Gutiérrez-León, Diana G.

Subjects
CARBON dioxide, HEAT exchangers, REFRIGERATION & refrigerating machinery, COMPUTATIONAL fluid dynamics, FLUID dynamics
Abstract

Transient behavior of internal heat exchanger during start-up of transcritical refrigeration system is investigated in this article. The work is focused on the local transient analysis of CO2thermophysical properties, in order to see how these transient changes affect the heat transfer rate and the effectiveness of internal heat exchanger, as well as the coefficient of performance during the start-up of the system. The study is conducted through a numerical simulation using the commercial computational fluid dynamics (CFD) software Ansys Fluent. Validation of numerical results is carried out by using seven different empirical correlations applied for the Nusselt number. It is observed that the thermophysical properties of the hot CO2stream experience large changes during the transient period. This instability is accompanied by a decrease in the heat transfer rate. Finally, the change in the internal heat exchanger effectiveness during the start-up results in a loss of about 12% of the coefficient of performance. [ABSTRACT FROM AUTHOR]

Published
2017
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37. Phosphoinositide 3-kinase p85beta regulates invadopodium formation

Author

Cariaga-Martínez, Ariel E., primary, Cortés, Isabel, additional, García, Esther, additional, Pérez-García, Vicente, additional, Pajares, María J., additional, Idoate, Miguel A., additional, Redondo-Muñóz, Javier, additional, Antón, Inés M., additional, and Carrera, Ana C., additional

Published
2014
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41. A promoter DNA demethylation landscape of human hematopoietic differentiation

Author

Calvanese, Vincenzo, primary, Fernández, Agustín F., additional, Urdinguio, Rocío G., additional, Suárez-Alvarez, Beatriz, additional, Mangas, Cristina, additional, Pérez-García, Vicente, additional, Bueno, Clara, additional, Montes, Rosa, additional, Ramos-Mejía, Verónica, additional, Martínez-Camblor, Pablo, additional, Ferrero, Cecilia, additional, Assenov, Yassen, additional, Bock, Christoph, additional, Menendez, Pablo, additional, Carrera, Ana Clara, additional, Lopez-Larrea, Carlos, additional, and Fraga, Mario F., additional

Published
2011
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43. Phosphoinositide 3-kinase beta controls replication factor C assembly and function

Author

José M. Valpuesta, Javier Redondo-Muñoz, María Josefa Rodríguez, Vicente Perez-Garcia, Ana C. Carrera, Virginia Silio, Redondo-Muñoz, Javier [0000-0003-0607-2171], Pérez-García, Vicente [0000-0001-5594-1607], Valpuesta, José María [0000-0001-7468-8053], Carrera, Ana C [0000-0002-3999-5434], and Apollo - University of Cambridge Repository

Subjects
Cell Nucleus, DNA Replication, DNA clamp, DNA Repair, Amino Acid Motifs, DNA replication, Eukaryotic DNA replication, Genome Integrity, Repair and Replication, Biology, DNA polymerase delta, Cell Line, Cell biology, Class Ia Phosphatidylinositol 3-Kinase, DNA replication factor CDT1, Protein Subunits, ran GTP-Binding Protein, Replication factor C, Biochemistry, Control of chromosome duplication, Genetics, biology.protein, Animals, Humans, Origin recognition complex, Replication Protein C
Abstract

Genomic integrity is preserved by the action of protein complexes that control DNA homeostasis. These include the sliding clamps, trimeric protein rings that are arranged around DNA by clamp loaders. Replication factor C (RFC) is the clamp loader for proliferating cell nuclear antigen, which acts on DNA replication. Other processes that require mobile contact of proteins with DNA use alternative RFC complexes that exchange RFC1 for CTF18 or RAD17. Phosphoinositide 3-kinases (PI3K) are lipid kinases that generate 3-poly-phosphorylated-phosphoinositides at the plasma membrane following receptor stimulation. The two ubiquitous isoforms, PI3Kalpha and PI3Kbeta, have been extensively studied due to their involvement in cancer and nuclear PI3Kbeta has been found to regulate DNA replication and repair, processes controlled by molecular clamps. We studied here whether PI3Kbeta directly controls the process of molecular clamps loading. We show that PI3Kbeta associated with RFC1 and RFC1-like subunits. Only when in complex with PI3Kbeta, RFC1 bound to Ran GTPase and localized to the nucleus, suggesting that PI3Kbeta regulates RFC1 nuclear import. PI3Kbeta controlled not only RFC1- and RFC-RAD17 complexes, but also RFC-CTF18, in turn affecting CTF18-mediated chromatid cohesion. PI3Kbeta thus has a general function in genomic stability by controlling the localization and function of RFC complexes.

Published
2012

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