446 results on '"Pérez-Ayala A"'
Search Results
2. Extremal metrics for the Paneitz Operator on closed four-Manifolds
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Pérez-Ayala, Samuel
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Mathematics - Differential Geometry ,Mathematics - Analysis of PDEs ,Mathematics - Spectral Theory - Abstract
Let $(M^4,g)$ be a closed Riemannian manifold of dimension four. We investigate the properties of metrics which are critical points of the eigenvalues of the Paneitz operator when considered as functionals on the space of Riemannian metrics with fixed volume. We prove that critical metrics of the aforementioned functional restricted to conformal classes are associated with a higher-order analog of harmonic maps (known as extrinsic conformal-harmonic maps) into round spheres. This extends to four-manifolds well-known results on closed surfaces relating metrics maximizing laplacian eigenvalues in conformal classes with the existence of harmonic maps into spheres. The case of general critical points (not restricted to conformal classes) is also studied, and partial characterization of these is provided.
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- 2022
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3. Isavuconazole Versus Voriconazole as the First-line Therapy for Solid Organ Transplant Recipients With Invasive Aspergillosis: Comparative Analysis of 2 Multicenter Cohort Studies
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Fernández-Ruiz, Mario, Gioia, Francesca, Bodro, Marta, Gutiérrez Martín, Isabel, Sabé, Núria, Rodriguez-Álvarez, Regino, Corbella, Laura, López-Viñau, Teresa, Valerio, Maricela, Illaro, Aitziber, Salto-Alejandre, Sonsoles, Cordero, Elisa, Arnaiz de Las Revillas, Francisco, Fariñas, María Carmen, Muñoz, Patricia, Vidal, Elisa, Carratalà, Jordi, Goikoetxea, Josune, Ramos-Martínez, Antonio, Moreno, Asunción, Martín-Dávila, Pilar, Fortún, Jesús, Aguado, José María, López-Medrano, Francisco, San Juan, Rafael, Linares, Laura, Lladó, Laura, González-Costello, José, Melilli, Edoardo, José Castón, Juan, Álvarez-Uría, Ana, Machado, Marina, Olmedo, María, Filigheddu, Eta, Moreno, Santiago, Cantón, Rafael, Pérez-Ayala, Ana, Calvo, Jorge, María Cifrián, José, Gonzalez-Rico, Claudia, Torre-Cisneros, Julián, del Mar Ras, María, Pérez, Sandra, Mónica López-Soria, Leyre, Linares, Laura, and Fernández-Cruz, Ana
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- 2024
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4. Digitalización de la comunicación y atención a personas LGBTIQ+: dos conflictos éticos emergentes para la Psicología en la Atención Primaria de Salud chilena
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Antonio Pérez-Ayala
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psicología ,atención primaria de salud ,conflictos éticos ,retos emergentes ,salud pública ,Jurisprudence. Philosophy and theory of law ,K201-487 ,Medical philosophy. Medical ethics ,R723-726 - Abstract
El artículo analiza los conflictos éticos detectados por Psicólogas/os en la Atención Primaria de Salud en Chile, centrando la descripción y análisis en los percibidos como emergentes, a través de un estudio cualitativo, tipo exploratorio-descriptivo. Dos fueron los principales conflictos identificados: a) resguardo de información sensible en ficha clínica electrónica y b) atención a personas LGBTIQ+ sin capacitación correspondiente. El estudio transparenta la importancia de visibilizar demandas incipientes en salud pública a través de las perspectivas de los propios profesionales, dotándoles de notoriedad para avanzar en su priorización y resolución. Explorar la dimensión ética es relevante para el ejercicio de la psicología contemporánea, porque da cuenta de las necesidades de la sociedad, permitiendo incluso anticiparse a ellas.
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- 2023
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5. Fluconazole-resistant Candida parapsilosis: fast detection of the Y132F ERG11p substitution, and a proposed microsatellite genotyping scheme
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Guinea, Jesús, Alcoceba, Eva, Padilla, Eduardo, Ramírez, Aída, De Carolis, Elena, Sanguinetti, Maurizio, Muñoz-Algarra, María, Durán-Valle, Teresa, Quiles-Melero, Inmaculada, Merino, Paloma, González-Romo, Fernando, Sánchez-García, Aída, Gómez-García-de-la-Pedrosa, Elia, Pérez-Ayala, Ana, Mantecón-Vallejo, María Ángeles, Pemán, Javier, Cuétara, María Soledad, Zurita, Nelly Daniela, García-Esteban, Coral, Martínez-Jiménez, María del Carmen, Sánchez Castellano, Miguel Ángel, Reigadas, Elena, Muñoz, Patricia, and Escribano, Pilar
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- 2024
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6. Extremal Eigenvalues Of The Conformal Laplacian Under Sire-Xu Normalization
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Pérez-Ayala, Samuel
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Mathematics - Differential Geometry - Abstract
Let $(M^n,g)$ be a closed Riemannian manifold of dimension $n\ge 3$. We study the variational properties of the $k$-th eigenvalue functional $\tilde g\in[g] \mapsto \lambda_k(L_{\tilde g})$ under a non-volume normalization proposed by Sire-Xu. We discuss necessary conditions for the existence of extremal eigenvalues under such normalization. Also, we discuss the general existence problem when $k=1$.
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- 2020
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7. Variational Properties Of The Second Eigenvalue Of The Conformal Laplacian
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Gursky, Matthew J. and Pérez-Ayala, Samuel
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Mathematics - Differential Geometry ,Mathematics - Analysis of PDEs - Abstract
Let $(M^n,g)$ be a closed Riemannian manifold of dimension $n\ge 3$. Assume $[g]$ is a conformal class for which the Conformal Laplacian $L_g$ has at least two negative eigenvalues. We show the existence of a (generalized) metric that maximizes the second eigenvalue of $L_g$ over all conformal metrics (the first eigenvalue is maximized by the Yamabe metric). We also show that a maximal metric defines either a nodal solution of the Yamabe equation, or a harmonic map to a sphere. Moreover, we construct examples of each possibility.
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- 2020
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8. Contenido esencial de los derechos fundamentales: fundamentación teórica y criterios de razonabilidad en el ordenamiento jurídico ecuatoriano
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Iliana López Ruiz, Tatiana Pérez Ayala, and Ana Lucia Vega Vega
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derechos ,contenido esencial ,jurisprudencia ,razonabilidad ,Jurisprudence. Philosophy and theory of law ,K201-487 - Abstract
El presente estudio valora las diferentes teorías que abordan el contenido esencial de los derechos fundamentales. Se analiza desde una perspectiva constitucional, esencialmente, visto como una garantía que opera frente al legislador. La investigación realiza un análisis de derecho comparado examinando jurisprudencia de países como España, Perú, Colombia, para finalmente, concatenar el desarrollo de estas proposiciones en el Ecuador. El objetivo fundamental se centra en abordar de manera crítica el desarrollo jurisprudencial ecuatoriano en cuanto a la determinación del núcleo duro, como también se le conoce a esta parte inquebrantable de los derechos, y propone la aplicación de nuevos criterios de razonabilidad para establecer su contenido y alcance. Se implementa el método cualitativo de investigación científica, esencialmente en lo referente a la recolección de información sobre aspectos relacionados con los enfoques teóricos que giran entorno a la determinación de esta zona infranqueable de los derechos fundamentales. Finalmente con el artículo se concluye que la principal dificultad que se presenta en el ordenamiento jurídico constitucional ecuatoriano es precisamente el hecho de que no se instituye una jerarquización de los derechos, es decir que, es realmente perentorio para el Ecuador desarrollar desde el punto de vista normativo estándares claros que permitan a los jueces que esta teoría del contenido esencial sea una herramienta valiosa al momento de emitir sus juicios de valor; teniendo en observancia elementos fundamentales como lo es la naturaleza jurídica, el bien protegido, su finalidad y su ejercicio funcional, a ello se suma la propuesta de la aplicación de criterios de razonabilidad para optimizar dicha valoración sobre todo cuando existen derecho fundamentales en contradicción.
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- 2023
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9. Variational properties of the second eigenvalue of the conformal Laplacian
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Gursky, Matthew J. and Pérez-Ayala, Samuel
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- 2022
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10. Detection of azole resistance in Aspergillus fumigatus complex isolates using MALDI-TOF mass spectrometry
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Sánchez-Yebra, Waldo, Sánchez-Gómez, Juan, Lozano, Inmaculada, Marfil, Eduardo, Muñoz de la Rosa, Montserrat, García, Rocío Tejero, Cobo, Fernando, Castro, Carmen, López, Concepción, Rezusta, Antonio, Peláez, Teresa, Castelló-Abietar, Cristian, Costales, Isabel, Serra, Julia Lozano, Jiménez, Rosa, Echeverría, Cristina Labayru, Pérez, Cristina Losa, Megías-Lobón, Gregoria, Lorenzo, Belén, Sánchez-Reus, Ferrán, Ayats, Josefina, Martín, María Teresa, Vidal, Inmaculada, Sánchez-Hellín, Victoria, Ibáñez, Elisa, Pemán, Javier, Fajardo, Miguel, Pazos, Carmen, Rodríguez-Mayo, María, Pérez-Ayala, Ana, Gómez, Elia, Guinea, Jesús, Escribano, Pilar, Serrano, Julia, Reigadas, Elena, Rodríguez, Belén, Zvezdanova, Estreya, Díaz-García, Judith, Gómez-Núñez, Ana, Leiva, José González, Machado, Marina, Muñoz, Patricia, Sánchez-Romero, Isabel, García-Rodríguez, Julio, Luis del Pozo, José, Vallejo, Manuel Rubio, Ruiz de Alegría-Puig, Carlos, López-Soria, Leyre, Marimón, José María, Vicente, Diego, Fernández-Torres, Marina, Hernáez-Crespo, Silvia, Zvezdanova, Margarita Estreya, Arroyo, Manuel J., Méndez, Gema, Candela, Ana, Mancera, Luis, Rodríguez, Julio García, and Rodríguez-Sánchez, Belén
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- 2022
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11. Environmental Justice and Equity: An Exploration through the POP Movement
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Ash Pachauri, Drishya Pathak, Komal Mittal, Meghana Elsa Thomas, Nahid Pérez Ayala, Norma Patricia Muñoz Sevilla, Philo Magdalene A, and Vanessa Anahí Hernández Vázquez
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sustainable development ,International relations ,JZ2-6530 ,Economic growth, development, planning ,HD72-88 - Abstract
Environmental Justice, defined as “The fair treatment and meaningful involvement of all people regardless of race, color, national origin, or income with respect to the development, implementation, and enforcement of environmental laws, regulations, and policies” (EPA), has been the object of study of this article in which it is shown how through the work of Non-Governmental Organizations (NGOs), the problem of inequalities and problems that arise in the day for certain communities and spaces can be revealed. The background shown and the methodology used are the result of numerous activities developed by “The POP Movement” (2016), in collaboration with various organizations, academic institutions, governments, civil society and particularly with young people from various countries around the world, among others: The International Conference and POP Festival for Youth-Led Climate Action; Intergenerational Dialogue on Environmental Justice and Equity; Latin American Dialogue; GlobalMindED Webinar and Truth and Reconciliation Week. The results obtained from the direct participation of the actors are shown through the problem analysis format, which are recorded within the framework of equity, justice, human rights and the environment, during the events. These results have allowed the design of strategies of action to address the identified problem, under the principle of “Youth inspired by Knowledge.” These results are manifested in various areas: Differentiated impact of climate change; Role of government in environmental justice, and Role of communities and other sectors. Finally, the conclusions obtained during the development of the various events mentioned are presented and that lead us to the following consideration, “The threat of the climate crisis is the one that looms over the world. And yet, the impact of climate change disproportionately affects some of the lives and livelihoods of the world’s most vulnerable and marginalized communities.”
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- 2021
12. Etiology and outcome of febrile children coming from the tropics
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Torres-Fernandez, David, Prieto Tato, Luis Manuel, Perez-Ayala, Ana, Moraleda, Cinta, Fernandez Cooke, Elisa, Blazquez-Gamero, Daniel, Rojo, Pablo, Perez Rivilla, Alfredo, and Epalza, Cristina
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- 2021
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13. Resguardos éticos de la investigación cualitativa en psicología
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Manuel Pérez Ayala
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psicología ,Investigación cualitativa ,resguardos éticos ,rigor científico ,Psychology ,BF1-990 - Abstract
Considerar los resguardos éticos presentes en la investigación constituye un imperativo que representa una garantía de calidad vinculada al rigor, confiabilidad y credibilidad ofrecida a cada participante y a la sociedad en su conjunto. A través de un estudio de diseño hermenéutico, se exploró sobre los resguardos éticos detectados por diez psicólogos dedicados a la investigación cualitativa. Los resultados permitieron categorizar en tres etapas el proceso investigativo: planificación, ejecución y evaluación, e indican la necesidad de desarrollar una reflexividad crítica que debe desplegarse en cada una de esas fases. Se concluye que la investigación cualitativa en psicología tiene un manifiesto compromiso social que demanda debatir sobre las prácticas académicas, y que la posición ética de quien investigue debe estar comprometida con el campo científico, así como con los participantes, a modo de reciprocidad para su perfeccionamiento constante.
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- 2022
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14. Correction: Díaz-García et al. Candida Genotyping of Blood Culture Isolates from Patients Admitted to 16 Hospitals in Madrid: Genotype Spreading during the COVID-19 Pandemic Driven by Fluconazole-Resistant C. parapsilosis. J. Fungi 2022, 8, 1228
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Judith Díaz-García, Ana Gómez, Marina Machado, Luis Alcalá, Elena Reigadas, Carlos Sánchez-Carrillo, Ana Pérez-Ayala, Elia Gómez-García de la Pedrosa, Fernando González-Romo, María Soledad Cuétara, Coral García-Esteban, Inmaculada Quiles-Melero, Nelly Daniela Zurita, María Muñoz Algarra, María Teresa Durán-Valle, Aída Sánchez-García, Patricia Muñoz, Pilar Escribano, Jesús Guinea, and on behalf of the CANDIMAD Study
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n/a ,Biology (General) ,QH301-705.5 - Abstract
In the original publication [...]
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- 2023
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15. Enhancing screening adherence for strongyloides infection in latinx inpatients with COVID-19: a local protocol implementation study.
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Pérez-Jacoiste Asín, María Asunción, De Castro, Marta, De Dios, Begoña, Pérez-Ayala, Ana, Lalueza, Antonio, García-Reyne, Ana, Losada, Irene, Herrero-Martínez, Juan María, Jiménez, Pilar Hernández, Lumbreras, Carlos, Lizasoain, Manuel, and López Medrano, Francisco
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MEDICAL screening ,COVID-19 - Abstract
Strongyloides stercoralis hyperinfection syndrome has been observed in immunosuppressed coronavirus disease 2019 (COVID-19) patients. Detecting and treating asymptomatic Strongyloides infection in individuals from endemic areas can effectively prevent hyperinfection. Unfortunately, many clinicians are unaware of this neglected infection. Therefore, we aimed to evaluate whether including Strongyloides screening in COVID-19 management protocols would encourage this practice. To accomplish this, we conducted a retrospective single-center study at 'Hospital Universitario 12 de Octubre' in Madrid, Spain, comparing two consecutive cohorts. The first cohort comprised all Latinx patients over 18 years old who were admitted for COVID-19 between March 1
st and April 30th , 2020. The second cohort consisted of Latinx patients admitted between July 1st and December 31st , 2020, following an amendment to the COVID-19 management protocol that recommended screening for strongyloidiasis in at-risk patients. We identified 559 and 795 patients in the first and second periods, respectively. The percentage of individuals screened increased significantly from 8.8% to 51.6% after the screening recommendation was included in the protocol (odds ratio [OR] 11.08, 95% confidence interval [CI] 8.01–15.33). In both periods, the screening rate was significantly higher among those receiving immunosuppression than those who did not receive steroids and/or tocilizumab. No other factors influenced the screening rate. In conclusion, including strongyloidiasis screening recommendations in COVID-19 management protocols led to its increased implementation. However, the overall screening rate remained low, emphasizing the need for further efforts to enhance screening practices. [ABSTRACT FROM AUTHOR]- Published
- 2024
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16. Diseño de un conjunto de indicadores sobre recomendaciones de «No Hacer»
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José Blázquez Álvarez, M., Farmacia, S., Pilar Ferrer Bas, M., Calidad Enfermería, A., García Gambín, Francisco, Evaluación, S., Pérez Ayala, Millán, Análisis Clínicos, S., Picazo Córdoba, Román, Documentación Clínica, S., Vera Guirao, Juan J., Informática, S., Moreno López, A.B., and López-Picazo Ferrer, J.J.
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- 2020
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17. Digitalización de la comunicación y atención a personas LGBTIQ+: dos conflictos éticos emergentes para la Psicología en la Atención Primaria de Salud chilena
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Pérez-Ayala, Antonio, primary
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- 2023
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18. Effectiveness of the Mangifera indica L. extract in patients with edematous and fibroedematous chronic gingivitis
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Orietta Pérez Ayala, Yassel Yoandris Vigo Pérez, Noris Lina Vizcay Herrezuelo, Dixan Gutiérrez Torres, and Julia Duarte Lisimón Duarte Lisimón
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enfermedad periodontal ,gingivitis crónica edematosa ,gingivitis crónica fibroedematosa ,mangifera indical ,antioxidante. ,Medicine (General) ,R5-920 ,Internal medicine ,RC31-1245 - Abstract
Introduction: Periodontal diseases are the most common affections of mankind and they are defined as a chronic immunoinflamatory reaction of the protection or insertion periodonto. Objective: To evaluate the effectiveness of the topic watery extract Mangifera indica L. as mouthwash in patients with edematous and fibroedematous chronic gingivitis. Methods: A study of therapeutic intervention was carried out in 84 patients with edematous and fibroedematous chronic gingivitis, assisted in Mártires del Moncada Teaching Provincial Stomatologic Clinic in Santiago de Cuba, from November, 2014 to the same month in 2015. The sample was divided in 2 groups (study and control) of 42 members each one, treated with topic watery extract of Mangifera indica L. and with watery solution of chlorhexidine at 0.2 %, respectively. The patients were evaluated at the beginning, at the 7, 14 and 21 days of having begun the treatment. A survey was applied for gathering the data and the Student T test, homogeneity test and the chi square test were used for the difference of samples, with p
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- 2019
19. Candida Genotyping of Blood Culture Isolates from Patients Admitted to 16 Hospitals in Madrid: Genotype Spreading during the COVID-19 Pandemic Driven by Fluconazole-Resistant C. parapsilosis
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Judith Díaz-García, Ana Gómez, Marina Machado, Luis Alcalá, Elena Reigadas, Carlos Sánchez-Carrillo, Ana Pérez-Ayala, Elia Gómez-García de la Pedrosa, Fernando González-Romo, María Soledad Cuétara, Coral García-Esteban, Inmaculada Quiles-Melero, Nelly Daniela Zurita, María Muñoz Algarra, María Teresa Durán-Valle, Aída Sánchez-García, Patricia Muñoz, Pilar Escribano, Jesús Guinea, and on behalf of the CANDIMAD Study Group
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Candida ,microsatellite genotyping ,blood culture ,intra-abdominal samples ,COVID-19 ,candidaemia ,Biology (General) ,QH301-705.5 - Abstract
Background: Candidaemia and invasive candidiasis are typically hospital-acquired. Genotyping isolates from patients admitted to different hospitals may be helpful in tracking clones spreading across hospitals, especially those showing antifungal resistance. Methods: We characterized Candida clusters by studying Candida isolates (C. albicans, n = 1041; C. parapsilosis, n = 354, and C. tropicalis, n = 125) from blood cultures (53.8%) and intra-abdominal samples (46.2%) collected as part of the CANDIMAD (Candida in Madrid) study in Madrid (2019–2021). Species-specific microsatellite markers were used to define the genotypes of Candida spp. found in a single patient (singleton) or several patients (cluster) from a single hospital (intra-hospital cluster) or different hospitals (widespread cluster). Results: We found 83 clusters, of which 20 were intra-hospital, 49 were widespread, and 14 were intra-hospital and widespread. Some intra-hospital clusters were first detected before the onset of the COVID-19 pandemic, but the number of clusters increased during the pandemic, especially for C. parapsilosis. The proportion of widespread clusters was significantly higher for genotypes found in both compartments than those exclusively found in either the blood cultures or intra-abdominal samples. Most C. albicans- and C. tropicalis-resistant genotypes were singleton and presented exclusively in either blood cultures or intra-abdominal samples. Fluconazole-resistant C. parapsilosis isolates belonged to intra-hospital clusters harboring either the Y132F or G458S ERG11p substitutions; the dominant genotype was also widespread. Conclusions: the number of clusters—and patients involved—increased during the COVID-19 pandemic mainly due to the emergence of fluconazole-resistant C. parapsilosis genotypes.
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- 2022
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20. Long-Term Follow-Up of Patients Diagnosed with COVID-19-Associated Pulmonary Aspergillosis (CAPA)
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María Ruiz-Ruigómez, Mario Fernández-Ruiz, Ana Pérez-Ayala, and José María Aguado
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COVID-19-associated pulmonary aspergillosis (CAPA) ,pulmonary aspergillosis ,antifungal ,Biology (General) ,QH301-705.5 - Abstract
COVID-19-associated pulmonary aspergillosis (CAPA) have been documented during the COVID-19 pandemic. The vast majority of these patients do not meet the classic EORTC/MSGERC criteria for invasive pulmonary aspergillosis. The question arises as to whether there may have been an over-diagnosis of this disease. Here we review our experience and analyze the evolution of 27 patients who were diagnosed with CAPA during hospital admission. Surviving patients were followed-up for a mean time of 15 months (SD 3.78) by a group of experts and clinical records of diseased patients were reviewed. After expert evaluation and follow-up, 10 patients were finally assumed as CAPA according to expert opinion. These cases represent 40% of the initially CAPA assumed cases. Our data suggest the need to reconsider actual diagnosis criteria for CAPA what could drive to better identification of these patients.
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- 2022
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21. Fluconazole‐resistant Candida parapsilosis genotypes from hospitals located in five Spanish cities and one in Italy: Description of azole‐resistance profiles associated with the Y132F ERG11p substitution.
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Mesquida, Aina, Alcoceba, Eva, Padilla, Eduardo, Ramírez, Aída, Merino, Paloma, González‐Romo, Fernando, De Carolis, Elena, Sanguinetti, Maurizio, Mantecón‐Vallejo, María de los Ángeles, Muñoz‐Algarra, María, Durán‐Valle, Teresa, Pérez‐Ayala, Ana, Gómez‐García‐de‐la‐Pedrosa, Elia, del Carmen Martínez‐Jiménez, María, Sánchez‐Castellano, Miguel Ángel, Quiles‐Melero, Inmaculada, Cuétara, María Soledad, Sánchez‐García, Aída, Muñoz, Patricia, and Escribano, Pilar
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CITIES & towns ,GENOTYPES ,AZOLES ,AMPHOTERICIN B ,CANDIDA ,HOSPITALS ,ANTIFUNGAL agents - Abstract
Background: Fluconazole‐resistant Candida parapsilosis is a matter of concern. Objectives: To describe fluconazole‐resistant C. parapsilosis genotypes circulating across hospitals in Spain and Rome and to study their azole‐resistance profile associated with ERG11p substitutions. Patients/Methods: We selected fluconazole‐resistant C. parapsilosis isolates (n = 528 from 2019 to 2023; MIC ≥8 mg/L according to EUCAST) from patients admitted to 13 hospitals located in five Spanish cities and Rome. Additionally, we tested voriconazole, posaconazole, isavuconazole, amphotericin B, micafungin, anidulafungin and ibrexafungerp susceptibility. Results: Of the 53 genotypes found, 49 harboured the Y132F substitution, five of which were dominating city‐specific genotypes involving almost half the isolates. Another genotype involved isolates harbouring the G458S substitution. Finally, we found two genotypes with the wild‐type ERG11 gene sequence and one with the R398I substitution. All isolates were fully susceptible/wild‐type to amphotericin B, anidulafungin, micafungin and ibrexafungerp. The azole‐resistance patterns found were: voriconazole‐resistant (74.1%) or voriconazole‐intermediate (25.2%), posaconazole‐resistant (10%) and isavuconazole non‐wild‐type (47.5%). Fluconazole‐resistant and voriconazole non‐wild‐type isolates were likely to harbour substitution Y132F if posaconazole was wild type; however, if posaconazole was non‐wild type, substitution G458S was indicated if isavuconazole MIC was >0.125 mg/L or substitution Y132F if isavuconazole MIC was ≤0.125 mg/L. Conclusions: We detected a recent clonal spread of fluconazole‐resistant C. parapsilosis across some cities in Spain, mostly driven by dominating city‐specific genotypes, which involved a large number of isolates harbouring the Y132F ERG11p substitution. Isolates harbouring substitution Y132F can be suspected because they are non‐susceptible to voriconazole and rarely posaconazole‐resistant. [ABSTRACT FROM AUTHOR]
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- 2024
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22. Malaria diagnosis using a combined system of a simple and fast extraction method with a lyophilised Dual-LAMP assay in a non-endemic setting.
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Martín Ramírez, Alexandra, Barón Argos, Lourdes, Lanza Suárez, Marta, Carmona Rubio, Claudia, Pérez-Ayala, Ana, Hisam, Shamilah R., and Rubio, José M.
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MALARIA ,PARASITIC diseases ,ADDITION reactions ,TROPICAL medicine ,DETECTION limit - Abstract
Malaria is a parasitic disease distributed in tropical areas but with a high number of imported cases in non-endemic countries. The most specific and sensitive malaria diagnostic methods are PCR and LAMP. However, both require specific equipment, extraction procedures and a cold chain. This study aims to solve some limitations of LAMP method with the optimization and validation of six LAMP assays, genus and species-specific, using an easy and fast extraction method, the incorporation of a reaction control assay, two ways (Dual) of result reading and reagent lyophilization. The Dual-LAMP assays were validated against the Nested-Multiplex Malaria PCR. A conventional column and saline extraction methods, and the use of lyophilized reaction tubes were also assessed. A new reaction control Dual-LAMP-RC assay was designed. Dual-LAMP-Pspp assay showed no cross-reactivity with other parasites, repeatability and reproducibility of 100%, a significant correlation between parasite concentration and time to amplification and a LoD of 1.22 parasites/µl and 5.82 parasites/µl using column and saline extraction methods, respectively. Sensitivity and specificity of the six Dual-LAMP assays reach values of 100% or close to this, being lower for the Dual-LAMP-Pm. The Dual-LAMP-RC assay worked as expected. Lyophilized Dual-LAMP results were concordant with the reference method. Dual-LAMP malaria assays with the addition of a new reaction control LAMP assay and the use of a fast and easy saline extraction method, provided low limit of detection, no cross-reactivity, and good sensitivity and specificity. Furthermore, the reagent lyophilization and the dual result reading allow their use in most settings. [ABSTRACT FROM AUTHOR]
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- 2024
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23. Conocimiento y calidad de vida en enfermedad renal crónica y diálisis peritoneal.
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García-Galicia, Arturo, Gracián-Castro, Esmeralda, Hinostrosa-Méndez, Alía, Benítez-Contreras, Amanda Ivonne, Pérez-Ayala, Karina Delfina, Montiel-Jarquín, Álvaro José, Bertado-Ramírez, Nancy Rosalía, and Loría-Castellanos, Jorge
- Abstract
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- 2024
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24. Enhancing screening adherence for strongyloides infection in latinx inpatients with COVID-19: a local protocol implementation study
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Pérez-Jacoiste Asín, María Asunción, primary, De Castro, Marta, additional, De Dios, Begoña, additional, Pérez-Ayala, Ana, additional, Lalueza, Antonio, additional, García-Reyne, Ana, additional, Losada, Irene, additional, Herrero-Martínez, Juan María, additional, Jiménez, Pilar Hernández, additional, Lumbreras, Carlos, additional, Lizasoain, Manuel, additional, and López Medrano, Francisco, additional
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- 2023
- Full Text
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25. Prevalence of submicroscopic malaria infection in immigrants living in Spain
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Isabel Fradejas, José Miguel Rubio, Ariadna Martín-Díaz, Juan María Herrero-Martínez, José Manuel Ruiz-Giardin, Gerardo Rojo-Marcos, María Velasco, María Calderón-Moreno, José Manuel Azcona-Gutierrez, Francisco Jesús Merino, Belén Andrés Olmo, María Espinosa, María Cuadrado, Esther González-Monte, Jerónimo Jaqueti, Juan Cuadros, Carolina Campelo, Alberto Delgado-Iribarren, Pablo Martín-Rabadán, Concepción García-García, María Ángeles Martín-Laso, Beatriz Valle-Borrego, María Coral García, Manuel Lizasoaín, and Ana Pérez-Ayala
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Plasmodium ,Afebrile malaria ,Submicroscopic parasitaemia ,Immigrant ,Tropical medicine ,Arctic medicine. Tropical medicine ,RC955-962 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background The importance of submicroscopic malaria infections in high-transmission areas could contribute to maintain the parasite cycle. Regarding non-endemic areas, its importance remains barely understood because parasitaemia in these afebrile patients is usually below the detection limits for microscopy, hence molecular techniques are often needed for its diagnosis. In addition to this, the lack of standardized protocols for the screening of submicroscopic malaria in immigrants from endemic areas may underestimate the infection with Plasmodium spp. The aim of this study was to assess the prevalence of submicroscopic malaria in afebrile immigrants living in a non-endemic area. Methods A prospective, observational, multicentre study was conducted. Afebrile immigrants were included, microscopic observation of Giemsa-stained thin and thick blood smears, and two different molecular techniques detecting Plasmodium spp. were performed. Patients with submicroscopic malaria were defined as patients with negative blood smears and detection of DNA of Plasmodium spp. with one or both molecular techniques. Demographic, clinical, analytical and microbiological features were recorded and univariate analysis by subgroups was carried out with STATA v15. Results A total of 244 afebrile immigrants were included in the study. Of them, 14 had a submicroscopic malaria infection, yielding a prevalence of 5.7% (95% confidence interval 3.45–9.40). In 71.4% of the positive PCR/negative microscopy cases, Plasmodium falciparum alone was the main detected species (10 out of the 14 patients) and in 4 cases (28.6%) Plasmodium vivax or Plasmodium ovale were detected. One patient had a mixed infection including three different species. Conclusions The prevalence of submicroscopic malaria in afebrile immigrants was similar to that previously described in Spain. Plasmodium vivax and P. ovale were detected in almost a third of the submicroscopic infections. Screening protocols for afebrile immigrants with molecular techniques could be useful for a proper management of these patients.
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- 2019
- Full Text
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26. Bruxism in pre-university students and its effects on the stomatognathic system
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Danisbel Pérez Ayala and Clara Zeyda Díaz Llana
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bruxismo ,sistema estomatognático ,hipertonía muscular ,signos y síntomas ,terapéutica. ,Medicine ,Medicine (General) ,R5-920 - Abstract
Introduction: bruxism is a parafunctional habit characterized by the incessant action of grinding and/or clenching teeth inappropriately, which causes alterations in the stomatognathic system. Objective: to describe the behavior of bruxism in pre-university students belonging to the health area of San Juan y Martínez municipality. Methods: a descriptive and cross-sectional study was carried out on young people enrolled at Isabel Rubio Diaz pre-university, San Juan y Martínez municipality, Pinar del Río province, during September 2017 to June 2018. The target group consisted of 570 students of both sexes enrolled in the morning session of the institute, with ages between 16 and 18 years. Selecting students with the clinical characteristics as bruxism (n=198). Data were processed through analytical statistics for each variable and the information was expressed in absolute and relative frequencies. Results: the highest number of patients affected belonged to female sex, predominantly in the 18-year-old group. The most frequently signs and symptoms found were headache and dental alterations, being stress the most associated risk factor with this disorder. Conclusions: the behavior of bruxism was described, which made it possible to propose new research on factors related to the origin and prevention of this disorder in order to control its associated risks and the harm of health.
- Published
- 2019
27. Dibenzothiophene hydrodesulfurization over ternary metallic NiMoW/Ti-HMS mesoporous catalysts
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R. Huirache-Acuña, E. Pérez-Ayala, M.E. Cervantes-Gaxiola, G. Alonso-Nuñez, T.A. Zepeda, E.M. Rivera-Muñoz, and B. Pawelec
- Subjects
NiMoW ,Ti-HMS ,Hydrodesulfurization ,Mesoporous silica ,Ternary metallic catalysts ,Chemistry ,QD1-999 - Abstract
Ternary sulfided NiMoW/Ti-HMS solids with varying Si/Ti ratio (e.g., 20, 40, 60) and with Ti incorporated via a post-synthesis method were evaluated in the hydrodesulfurization of dibenzothiophene. Ti-incorporation improved the catalytic activity of the samples up to 2.4 times compared to the sample without titanium and to a reference industrial catalyst. The performance was mainly associated with differences observed in the stacking and length and the dispersion of the active phase, this effect being stronger for the NiMoW/HMS-Ti 20 sample. The latter displayed the highest catalytic activity and sulfur removal via hydrogenation.
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- 2021
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28. Profile of a group of university audience in Mexico according to their citizen participation, trust in institutions and civic interaction in the media in 2017.
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Santana, J. C., López-Hernández, C., Gutiérrez-Rentería, M. E., Pérez-Ayala Madero, M. G., and Hellmueller, L.
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university audience ,social capital ,trust ,Communication. Mass media ,P87-96 ,Journalism. The periodical press, etc. ,PN4699-5650 - Abstract
The present quantitative study shows the singularities of the university audience in Mexico in 2017, measured according to their civic participation, how they assess national institutions, and how they interact with the media regarding social and political issues. The surveyed population consisted of 1,195 young adults of 23 years of average age and who are part of private universities located in Jalisco, Mexico City and Aguascalientes. The results indicate that the offline participation in social capital is more significant than online participation of this university audience. The only institutions that have an approval index for this audience are religious institutions, universities, and the media. Finally, the university audience in Mexico has features of being passive and conservative regarding its consumption of information and its political participation in media. This population reflects apathy in expressing their opinion in media regarding social and political issues in the country.
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- 2018
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29. Study of the diagnostic accuracy of microbiological techniques in the diagnosis of malaria in the immigrant population in Madrid
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Ariadna Martín-Díaz, José Miguel Rubio, Juan María Herrero-Martínez, Manolo Lizasoain, José Manuel Ruiz-Giardin, Jerónimo Jaqueti, Juan Cuadros, Gerardo Rojo-Marcos, Pablo Martín-Rabadán, María Calderón, Carolina Campelo, María Velasco, and Ana Pérez-Ayala
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Submicroscopic parasitaemia ,PCR Plasmodium ,Malaria diagnosis ,Arctic medicine. Tropical medicine ,RC955-962 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Malaria is currently the most important human parasitic disease in the world responsible for high morbidity and mortality. Appropriate diagnostic methods are essential for early detection. Microscopy examination remains the gold standard, although molecular techniques have higher sensitivity and are very useful in cases of low parasitaemia and mixed infections. The objective of this study was to evaluate a new commercial molecular diagnostic technique. Methods A prospective, observational, multicentre study was performed between January 2015 and April 2017. All participants were immigrants from malaria-endemic areas, who were divided into two groups: asymptomatic group and symptomatic. Samples from both groups were evaluated by a rapid diagnostic test (ImmunoQuick® Malaria + 4 RDT), microscopy examination, and two commercial molecular malaria tests (FTD Malaria and FTD Malaria Differentiation), then compared against an in-house reference PCR technique. Results In all, 250 patients were included: 164 (65.6%) in the asymptomatic group, and 86 (34.4%) in the symptomatic group. There were seven cases of asymptomatic parasitaemia (prevalence = 2.8%) that were detected only by molecular methods. In the symptomatic group, there were seven cases of submicroscopic malaria. The main species detected was Plasmodium falciparum (96.6%). The commercial molecular technique had higher sensitivity than the other methods (S = 96%) and a high rate of concordance with the in-house reference PCR technique (Kappa score = 0.93). Conclusions The molecular techniques, although slower than microscopy, have adequate diagnostic accuracy and are very useful for the detection of P. falciparum in cases with low parasitaemia.
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- 2018
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30. Claves éticas en el tratamiento clínico-comunitario de personas con esquizofrenia
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Manuel Pérez Ayala
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ética ,esquizofrenia ,salud mental ,tratamiento clínico-comunitario ,vulnerabilidad ,autonomía ,consentimiento informado ,confidencialidad ,Jurisprudence. Philosophy and theory of law ,K201-487 ,Medical philosophy. Medical ethics ,R723-726 - Abstract
Este artículo discute la consideración de algunos elementos éticos fundamentales en la intervención a personas con esquizofrenia, en el ámbito clínico y comunitario, escenarios preferentes de las prestaciones de salud en la actualidad. Los conceptos tratados son vulnerabilidad, autonomía y paternalismo, consentimiento informado y confidencialidad. Se expone la necesidad de que los profesionales de la salud mental reflexionen sobre el tipo de intervenciones realizadas, integrando en cada caso la opinión y deseos de los pacientes, así como de sus familiares y/o tutores. Se pregunta si estos aspectos son o no considerados y cómo mejorarlos, resguardando los intereses de los intervenidos y no transgrediendo el respeto y dignidad en un marco ético consensuado y mínimo.
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- 2017
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31. Non-Candida isolates from blood cultures and intra-abdominal samples: data derived from a multicentre prospective study conducted in Madrid
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Díaz-García, Judith, primary, Gómez, Ana, additional, Machado, Marina, additional, Alcalá, Luis, additional, Reigadas, Elena, additional, Sánchez-Carrillo, Carlos, additional, Pérez-Ayala, Ana, additional, Gómez-García de la Pedrosa, Elia, additional, González-Romo, Fernando, additional, Cuétara, María Soledad, additional, García-Esteban, Coral, additional, Quiles-Melero, Inmaculada, additional, Zurita, Nelly Daniela, additional, Muñoz-Algarra, María, additional, Durán-Valle, María Teresa, additional, Sánchez-García, Aída, additional, Muñoz, Patricia, additional, Escribano, Pilar, additional, and Guinea, Jesús, additional
- Published
- 2023
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32. Contenido esencial de los derechos fundamentales: fundamentación teórica y criterios de razonabilidad en el ordenamiento jurídico ecuatoriano
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López Ruiz, Iliana, primary, Pérez Ayala, Tatiana, primary, and Vega Vega, Ana Lucia, primary
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- 2023
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33. Unusual microscopic finding in a hepatic abscess content
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Rolo, Marta, primary, Reyes, Alhena, additional, Torres, Juan Martín, additional, and Pérez-Ayala, Ana, additional
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- 2023
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34. Prevalence of Chagas disease in Latin American pregnant women in Madrid, Spain: A multicentre cross‐sectional study from 2011 to 2016.
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Herrero‐Martínez, Juan María, Trigo, Elena, Navarro, Miriam, García‐Alcázar, Diana, Carrillo, Irene, Fernández‐López, Tania, Calderón‐Moreno, María, Millán‐Pérez, Rosario, Cuadros, Juan, Velasco, María, García‐Bujalance, Silvia, Lizasoain, Manuel, Martín‐Rabadán, Pablo, Pérez‐Ayala, Ana, Flores‐Chávez, María, Aguado, Isabel, Aguinaga, Marisa, Álvaro, Miguel, Antón, Berta, and Arango, Esther
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CHAGAS' disease ,DISEASE prevalence ,MEDICAL screening ,CROSS-sectional method ,COUNTRY of origin (Immigrants) - Abstract
Objective: The aim of this study is to assess Trypanosoma cruzi infection prevalence among pregnant migrants living in Madrid according to the country of origin and to assess screening coverage in this at‐risk population. Methods: Retrospective multicentre cross‐sectional study conducted from January 2011 to December 2016 in eight Madrid hospitals. Each hospital reviewed their microbiology data records to assess the screening coverage and serological diagnosis in all pregnant women coming from endemic areas. Results: From 2011 to 2016, 149,470 deliveries were attended at the eight hospitals, and 11,048 pregnant women were screened for Chagas disease. Most cases (93.5%) were in women from Bolivia, who also showed the highest prevalence (12.4%, 95% confidence interval: 9.9–15.0). Pooled prevalence amongst the screened women was 2.9% (95% CI: 1.8–4.1). Chagas disease screening coverage varied greatly between centres, with a pooled mean coverage of 47% (95% CI: 37%–57%; 73% [95% CI: 63%–82%] for those centres with universal screening vs. 10% [95% CI: 6%–15%] for those with a selective screening approach; p < 0.001). Conclusion: Our study provides useful data for policy makers and epidemiologists in a non‐endemic area without congenital Chagas screening programmes. [ABSTRACT FROM AUTHOR]
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- 2023
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35. Azole resistance survey on clinical Aspergillus fumigatus isolates in Spain
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Sánchez-Yebra, Waldo, Sánchez-Gómez, Juan, Lozano, Inmaculada, Marfil, Eduardo, Muñoz de la Rosa, Montserrat, García, Rocío Tejero, Cobo, Fernando, Castro, Carmen, López, Concepción, Rezusta, Antonio, Peláez, Teresa, Castelló-Abietar, Cristian, Costales, Isabel, Serra, Julia Lozano, Jiménez, Rosa, Echeverría, Cristina Labayru, Pérez, Cristina Losa, Megías-Lobón, Gregoria, Lorenzo, Belén, Sánchez-Reus, Ferrán, Ayats, Josefina, Martín, María Teresa, Vidal, Inmaculada, Sánchez-Hellín, Victoria, Ibáñez, Elisa, Pemán, Javier, Fajardo, Miguel, Pazos, Carmen, Rodríguez-Mayo, María, Pérez-Ayala, Ana, Gómez, Elia, Guinea, Jesús, Escribano, Pilar, Serrano, Julia, Reigadas, Elena, Rodríguez, Belén, Zvezdanova, Estreya, Díaz-García, Judith, Gómez-Núñez, Ana, Leiva, José González, Machado, Marina, Muñoz, Patricia, Sánchez-Romero, Isabel, García-Rodríguez, Julio, Luis del Pozo, José, Vallejo, Manuel Rubio, Ruiz de Alegría-Puig, Carlos, López-Soria, Leyre, Marimón, José María, Vicente, Diego, Fernández-Torres, Marina, Hernáez-Crespo, Silvia, Rodríguez-Sánchez, Belén, Martín-Gómez, María Teresa, Ibáñez-Martínez, Elisa, García-Gómez de la Pedrosa, Elia, Tejero-García, Rocío, Labayru-Echeverría, Cristina, and Alastruey-Izquierdo, Ana
- Published
- 2021
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36. Environmental Factors as Key Determinants for Visceral Leishmaniasis in Solid Organ Transplant Recipients, Madrid, Spain
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Nerea Carrasco-Antón, Francisco López-Medrano, Mario Fernández-Ruiz, Eugenia Carrillo, Javier Moreno, Ana García-Reyne, Ana Pérez-Ayala, María Luisa Rodríguez-Ferrero, Carlos Lumbreras, Rafael San-Juan, Jorge Alvar, and José María Aguado
- Subjects
solid organ transplantation ,visceral leishmaniasis ,epidemiology ,risk factors ,urban outbreak ,parasites ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
During a visceral leishmaniasis outbreak in an area of Madrid, Spain, the incidence of disease among solid organ transplant recipients was 10.3% (7/68). Being a black person from sub-Saharan Africa, undergoing transplantation during the outbreak, and residing
- Published
- 2017
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37. Smartphone: usos y gratificaciones de los jóvenes en México en 2015
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María Elena Gutiérrez-Rentería, Josefina C. Santana-Villegas, and Martha Pérez-Ayala
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Communication. Mass media ,P87-96 ,Journalism. The periodical press, etc. ,PN4699-5650 - Abstract
Esta investigación forma parte de un estudio realizado entre Chile, los Es-tados Unidos y México para identificar los usos que los jóvenes hispanos les dan a sus teléfonos inteligentes conocidos como smartphones. El obje-tivo del estudio es identificar los hábitos de consumo, las preferencias de este medio respecto de otros, así como las principales actividades que rea-lizan los jóvenes mexicanos a través de su teléfono celular. El método de in-vestigación que guía el estudio es mixto, dado que se utilizan técnicas para obtener los resultados de forma cualitativa, a través de encuestas focales, y cuantitativa, a través de encuestas en línea. La población indagada forma parte de los jóvenes de entre 18 y 25 años que estudian en una Universi-dad privada en el área metropolitana de Guadalajara. En las encuestas fo-cales participaron 27 alumnos y se aplicaron 707 encuestas en línea. Los resultados muestran que el smartphone ha puesto al alcance aplicaciones que satisfacen diversas necesidades de comunicación de forma instantá-nea; los jóvenes utilizan este dispositivo más de cinco horas diarias, siendo WhatsApp la red social más importante para comunicarse con su familia y amigos. A manera de conclusión, puede decirse que, para esta población es-tudiada, existe una relación directa respecto del género de la persona para la elección de la marca, el tiempo de consumo y, finalmente, para la elec-ción de uso de los smartphones frente a otras redes sociales en línea y me-dios de comunicación.
- Published
- 2017
38. ¿Es precipitado aún hablar del impacto e implicancias éticas del transhumanismo para la Psicología?
- Author
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Manuel Pérez Ayala
- Subjects
General Medicine - Abstract
Este artículo propone una revisión crítica sobre los alcances del transhumanismo en la esfera de la Psicología. Para ello, se expondrán antecedentes y se definirá lo que se entiende por transhumanismo y el resultado de éste, denominado poshumanismo. A través de características humanas tan básicas y diversas como la cognición, el sufrimiento y la identidad, se discute sobre los inéditos cambios que la ejecución y logro de las propuestas transhumanistas significarían para la sociedad, el cómo la psicología podría prever y anticipar un escenario así de radical, y la necesidad y urgencia de nuevas teorías éticas que ayuden a comprender los fenómenos en cuestión.
- Published
- 2022
39. A piece of software for the management of Clinical History in Comprehensive Dentistry Care
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Danisbel Pérez Ayala, Yusnay HernándezCastro, Carlos Adam Alvarez Osorio, Yaniel Alvarez Sánchez, and María Del Carmen Rodríguez Fuego
- Subjects
Software, historia clínica, Estomatología General Integral. ,Medicine ,Medicine (General) ,R5-920 - Abstract
Introduction: nowadays computing brings great benefits to store, process and transmit information and data. Dental clinics are institutions where daily information is handled day-to-day, specifically medical records. Objective: to develop an automated system for the management of clinical histories in Comprehensive Dentistry Care Method: a technological development research based on a quantitative-qualitative and cross-sectional study was conducted at Pedro Borras Astorga University Polyclinic and at Antonio Briones Montoto Dentistry Clinic. The target group included all the patients who requested dentistry care service from both institutions, and the sample was constituted by patients who received the service of Comprehensive Dentistry Care of a chosen polyclinic from Pinar del Rio municipality. Results: a Computerized System for the management of dentistry clinical history was built in the specialty of Comprehensive Dentistry Care. Conclusions: the computer system will be developed with basic and technical requirements that are necessary for the functioning of a dentistry clinic. It will have a great professional impact since its functional and operational performance will significantly help in the organization and control of patients. The use of a piece of software will meet the expectations of doing research and of business actors along with the criteria of experts, who are part of the study and agree with the need to develop a product having a trouble-free design and format, which will allow the incorporation of data in the system and its later generalization. DeCS: Software, clinical history, Comprehensive Dentistry Care
- Published
- 2016
40. Detection of azole resistance in Aspergillus fumigatus complex isolates using MALDI-TOF mass spectrometry
- Author
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Margarita Estreya Zvezdanova, Manuel J. Arroyo, Gema Méndez, Ana Candela, Luis Mancera, Julio García Rodríguez, Julia Lozano Serra, Rosa Jiménez, Inmaculada Lozano, Carmen Castro, Concepción López, Patricia Muñoz, Jesús Guinea, Pilar Escribano, Belén Rodríguez-Sánchez, Waldo Sánchez-Yebra, Juan Sánchez-Gómez, Eduardo Marfil, Montserrat Muñoz de la Rosa, Rocío Tejero García, Fernando Cobo, Antonio Rezusta, Teresa Peláez, Cristian Castelló-Abietar, Isabel Costales, Cristina Labayru Echeverría, Cristina Losa Pérez, Gregoria Megías-Lobón, Belén Lorenzo, Ferrán Sánchez-Reus, Josefina Ayats, María Teresa Martín, Inmaculada Vidal, Victoria Sánchez-Hellín, Elisa Ibáñez, Javier Pemán, Miguel Fajardo, Carmen Pazos, María Rodríguez-Mayo, Ana Pérez-Ayala, Elia Gómez, Julia Serrano, Elena Reigadas, Belén Rodríguez, Estreya Zvezdanova, Judith Díaz-García, Ana Gómez-Núñez, José González Leiva, Marina Machado, Isabel Sánchez-Romero, Julio García-Rodríguez, José Luis del Pozo, Manuel Rubio Vallejo, Carlos Ruiz de Alegría-Puig, Leyre López-Soria, José María Marimón, Diego Vicente, Marina Fernández-Torres, and Silvia Hernáez-Crespo
- Subjects
Azoles ,0301 basic medicine ,Microbiology (medical) ,Species complex ,Antifungal Agents ,Sequence analysis ,030106 microbiology ,ASPERGILLUS FUMIGATUS COMPLEX ,Azole resistance ,Microbial Sensitivity Tests ,Gene mutation ,Biology ,Mass spectrometry ,Aspergillus fumigatus ,03 medical and health sciences ,0302 clinical medicine ,Drug Resistance, Fungal ,parasitic diseases ,Humans ,030212 general & internal medicine ,Genetics ,chemistry.chemical_classification ,General Medicine ,bacterial infections and mycoses ,biology.organism_classification ,Infectious Diseases ,chemistry ,Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ,Azole - Abstract
Objectives The main goal of this study was to accurately detect azole resistance in species of the Aspergillus fumigatus complex by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Methods Identification of isolates (n = 868) was done with MALDI-TOF MS using both commercial and in-house libraries. To determine azole susceptibility, the EUCAST E.Def. 9.3.2 method was applied as the reference standard. Identification of resistant isolates was confirmed by DNA sequence analysis. Protein spectra obtained by MALDI-TOF MS were analysed to differentiate species within the A. fumigatus complex and to detect azole-resistant A. fumigatus sensu stricto isolates. Results Correct discrimination of A. fumigatus sensu stricto from cryptic species was accomplished in 100% of the cases applying principal component analysis (PCA) to protein spectra generated by MALDI-TOF MS. Furthermore, a specific peak (4586 m/z) was found to be present only in cryptic species. The application of partial least squares (PLS) discriminant analysis allowed 98.43% (±0.038) discrimination between susceptible and azole-resistant A. fumigatus sensu stricto isolates. Finally, based on PLS and SVM, A. fumigatus sensu stricto isolates with different cyp51A gene mutations were correctly clustered in 91.5% of the cases. Conclusions MALDI-TOF MS combined with peak analysis is a novel tool that allows the differentiation of A. fumigatus sensu stricto from other species within the A. fumigatus complex, as well as the detection of azole-resistant A. fumigatus sensu stricto. Although further studies are still needed, the results reported here show the great potential of MALDI-TOF and machine learning for the rapid detection of azole-resistant Aspergillus fumigatus isolates from clinical origins.
- Published
- 2022
41. Unusual microscopic finding in a hepatic abscess content
- Author
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Marta Rolo, Alhena Reyes, Juan Martín Torres, and Ana Pérez-Ayala
- Subjects
Microbiology (medical) ,General Medicine - Published
- 2023
42. Prevalence of submicroscopic malaria infection in immigrants living in Spain
- Author
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Fradejas, Isabel, Rubio, José Miguel, Martín-Díaz, Ariadna, Herrero-Martínez, Juan María, Ruiz-Giardin, José Manuel, Rojo-Marcos, Gerardo, Velasco, María, Calderón-Moreno, María, Azcona-Gutierrez, José Manuel, Merino, Francisco Jesús, Olmo, Belén Andrés, Espinosa, María, Cuadrado, María, González-Monte, Esther, Jaqueti, Jerónimo, Cuadros, Juan, Campelo, Carolina, Delgado-Iribarren, Alberto, Martín-Rabadán, Pablo, García-García, Concepción, Martín-Laso, María Ángeles, Valle-Borrego, Beatriz, García, María Coral, Lizasoaín, Manuel, and Pérez-Ayala, Ana
- Published
- 2019
- Full Text
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43. ¿Por qué hablar de bioética en la atención primaria en salud?
- Author
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Manuel Pérez Ayala
- Subjects
bioética ,atención primaria de salud ,salud pública ,calidad ,equidad ,Medical philosophy. Medical ethics ,R723-726 ,Ethics ,BJ1-1725 - Abstract
Este trabajo tiene como objetivo plantear una reflexión sobre la necesidad de incluir de manera efectiva planteamientos bioéticos en la atención primaria de salud (aps) en el contexto latinoamericano, describiendo y proponiendo aspectos relevantes en los cuales la disciplina concretamente puede aportar. Caracterizada la aps con prestaciones desplegadas, tanto a nivel individual, como comunitario, se describen sus desafíos futuros y el horizonte mismo que la bioética tiene en ella, con lo cuals e contribuye a optimizar el cuidado de la salud y así se dota de excelencia el actuar profesional y sus procedimientos, y se humaniza el acto de atención en salud pública. Se concluye que los criterios que abogaban por la cantidad en este nivel de salud afectaron negativamente a la expresión de una calidad total hacia los beneficiarios; también ha mermado el impacto de la bioética asimilada en la salud pública. Superada esta transición, la bioética es llamada a integrar la calidad en salud, lo que a su vez acorta significativamente la brecha existente hacia la equidad.
- Published
- 2016
44. Extremal metrics for the Paneitz operator on closed four-manifolds
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Pérez-Ayala, Samuel, primary
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- 2022
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45. La influencia de algunos factores de riesgo en las periodontopatías.
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Danisbel Pérez Ayala and Yaimara Pérez Hernández
- Subjects
factores de riesgo ,periodoncia ,placa dental. ,Medicine ,Medicine (General) ,R5-920 - Abstract
Introducción: las periodontopatías constituyen una amenaza para la salud bucal. Aunque su etiología es multicausal los factores locales son los que más frecuentemente lo originan.Objetivo: identificar el comportamiento de algunos factores de riesgo en la aparición de periodontopatías.Métodos: se realizó un estudio descriptivo prospectivo en el consultorio 18 del Policlínico Dr. Modesto Gómez Rubio, municipio San Juan y Martínez, de febrero a diciembre del 2013 con el objetivo de identificar el comportamiento de algunos factores de riesgo en la aparición de periodontopatías. El universo estuvo constituido por 592 individuos, y la muestra quedó integrada por 269 pacientes. Se evaluaron variables como edad, sexo, nivel educacional, presencia de enfermedad periodontal y algunos factores de riesgo.Resultados: los pacientes que presentaban enfermedad periodontal eran fundamentalmente féminas y pertenecían a la población de entre 20-59 años. El mayor número de enfermos tenía nivel educacional medio, higiene bucal deficiente y practicaban el hábito de fumar. El factor de riesgo que más afectó la población fue la presencia de placa dental bacteriana con 238 pacientes para un 88,4 %.Conclusiones: se identificó el comportamiento de algunos factores de riesgo en la aparición de periodontopatías lo que posibilita hacer mayor énfasis en la prevención y el tratamiento periodontal primario.
- Published
- 2015
46. Bélgica, un modelo de construcción nacional
- Author
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Andoni Pérez Ayala
- Subjects
History (General) ,D1-2009 - Published
- 2018
- Full Text
- View/download PDF
47. El absceso dentoalveolar agudo como urgencia estomatológica en pacientes adultos
- Author
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Danisbel Pérez Ayala
- Subjects
Absceso periapical ,Urgencias médicas ,Medicine ,Medicine (General) ,R5-920 - Abstract
Introducción: en la práctica estomatológica, uno de los procesos periapicales más comúnmente observados en los servicios de urgencias, es el absceso dentoalveolar agudo. Objetivo: describir el comportamiento del absceso dentoalveolar agudo como urgencia en la población adulta. Material y método: se realizó un estudio descriptivo, de corte transversal en la Clínica Estomatológica “Hermanos Saiz” del municipio San Juan y Martínez, Pinar del Río, de septiembre de 2013 a septiembre de 2014. El universo estuvo constituido por 120 pacientes con diagnóstico de absceso dentoalveolar agudo según las características clínicas y antecedentes del paciente obtenidos en el interrogatorio. De ellos, se seleccionaron 80 pacientes al azar como muestra. Se procesaron los datos manualmente y presentaron en tablas utilizando el por ciento como medida resumen. Resultados: el mayor número de pacientes afectados correspondió al sexo masculino con un predominio del grupo de edad de 35-59 años. Las fases clínicas I y II fueron las más frecuentes, los molares inferiores resultaron las piezas dentarias más vulnerables; el dolor fue el síntoma más prevaleciente, mientras que nadie acudió aquejado por presentar malestar general. El diagnóstico de esta patología en estadio inicial (fase I) es directamente proporcional a una evolución favorable del cuadro clínico. Conclusiones: se describió el comportamiento del absceso dentoalveolar agudo como urgencia en la población adulta, lo que posibilita proponer nuevas investigaciones sobre factores relacionados con el origen y prevención de dicha enfermedad.
- Published
- 2015
48. La rehabilitación protésica en las lesiones bucales del adulto mayor
- Author
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Yaimara Pérez Hernández, Danisbel Pérez Ayala, Milians Planes Elisberth, Clara Zeida Díaz, and Yarielys Vento Blanco
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Prótesis dental ,Mucosa bucal ,Medicine ,Medicine (General) ,R5-920 - Abstract
Introducción: las lesiones en la mucosa bucal relacionadas con el uso de prótesis constituyen un problema importante de salud, fundamentalmente en pacientes geriátricos. Objetivo: caracterizar las lesiones bucales en pacientes geriátricos rehabilitados protésicamente. Material y método: se realizó un estudio descriptivo, transversal y prospectivo en los consultorios médicos #9 y 47 de la Clínica Estomatológica Hermanos Saiz, municipio San Juan y Martínez, Pinar del Río, de septiembre de 2012 a septiembre de 2013. El universo estuvo conformado por 165 pacientes rehabilitados protésicamente, de los cuales 98 constituyeron la muestra, siendo pacientes que presentaron lesiones bucales producto del uso de prótesis. Como medida de resumen se utilizaron el número absoluto y el porcentaje. Resultados: el mayor número de pacientes se encontraban en edades entre 65 y 69 años, el sexo más afectado fue el femenino y las lesiones se encontraron principalmente en el maxilar y en pacientes que usaban prótesis totales de acrílico. Los pacientes que presentaban mala higiene de la prótesis eran más propensos a lesiones bucales. El mayor número de lesiones se encontró en pacientes que no practicaban el hábito de fumar. Conclusiones: se caracterizaron las lesiones bucales en pacientes geriátricos rehabilitados protésicamente, lo que posibilita proponer nuevas investigaciones sobre factores relacionados con el origen y prevención de dichas lesiones producto del uso de prótesis, y así mantener la comunicación necesaria de los implicados en el diagnóstico y atención de las personas longevas.
- Published
- 2015
49. Trends in imported malaria during the COVID-19 pandemic, Spain (+Redivi Collaborative Network)
- Author
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Francesca F, Norman, Begoña, Treviño-Maruri, José Manuel, Ruiz Giardín, Beatriz, Gullón-Peña, Fernando, Salvador, Nuria, Serre, Marta, Díaz-Menéndez, Eva, Calabuig, Azucena, Rodriguez-Guardado, Itxaso, Lombide, Ana, Pérez-Ayala, Diego, Torrús, Josune, Goikoetxea, Magdalena, García-Rodriguez, and Jose A, Pérez-Molina
- Subjects
Adult ,Male ,Travel ,Spain ,Plasmodium falciparum ,COVID-19 ,Humans ,General Medicine ,Travel-Related Illness ,Pandemics ,Malaria - Abstract
Introduction The COVID-19 pandemic has caused disruptions in prevention and management strategies for malaria globally. Currently, data analysing trends in travel-related infections during the pandemic years are scarce. The objective of this analysis was to describe the epidemiological and clinical characteristics of patients with imported malaria within the +Redivi network in Spain, focusing on yearly trends from pre-pandemic years to date. Methods Cases recorded in +Redivi from October 2009 to December 2021 were analysed and patients with a diagnosis of malaria (standard diagnostic methods using thick/thin peripheral blood smears, with/without a malaria rapid diagnostic test and/or Plasmodium spp. polymerase chain reaction) were identified. The total number of malaria cases, cases according to type of patient and severe cases, per year, were analysed. Results In total, 1751 cases of malaria (1751/26 601, 6.6%) were identified. The majority occurred in males (1041, 59.5%), median age was 36.3 (interquartile range: 27–44.7) years and most occurred in visiting friends and relatives (VFR)-immigrants (872, 49.8%). Most infections were acquired in sub-Saharan Africa (1.660, 94.8%) and were due to Plasmodium falciparum (81.3%). There were 64 cases of severe malaria (3.7%) and 4 patients died (0.2% mortality, all in pre-pandemic years). A significant increase in cases of severe malaria was observed during the study period (P Conclusions After an initial decline associated with travel restrictions due to the ongoing COVID-19 pandemic, an increase in imported malaria and a significant increase in cases of severe malaria was observed. Patients with imported malaria may present and/or be diagnosed late during this public health crisis and health care professionals should be alerted to the recent increase in severe cases.
- Published
- 2022
50. Evidence of Fluconazole-Resistant Candida parapsilosis Genotypes Spreading across Hospitals Located in Madrid, Spain and Harboring the Y132F ERG11p Substitution
- Author
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Judith Díaz-García, Ana Gómez, Luis Alcalá, Elena Reigadas, Carlos Sánchez-Carrillo, Ana Pérez-Ayala, Elia Gómez-García de la Pedrosa, Fernando González-Romo, Paloma Merino-Amador, María Soledad Cuétara, Coral García-Esteban, Inmaculada Quiles-Melero, Nelly Daniela Zurita, María Muñoz-Algarra, Isabel Sánchez-Romero, María Teresa Durán-Valle, Aída Sánchez-García, Eva Alcoceba, Patricia Muñoz, Pilar Escribano, and Jesús Guinea
- Subjects
Pharmacology ,Infectious Diseases ,Antifungal Agents ,Candida parapsilosis ,Genotype ,Susceptibility ,Drug Resistance, Fungal ,Spain ,Humans ,Pharmacology (medical) ,Microbial Sensitivity Tests ,Fluconazole ,Hospitals - Abstract
We have been monitoring the antifungal resistance in Candida parapsilosis isolates collected from inpatients at Madrid metropolitan area hospitals for the last 3 years. The study aimed to elucidate the presence of fluconazole-resistant C. parapsilosis genotypes in Madrid. From January 2019 to December 2021, a total of 354 C. parapsilosis isolates (n = 346 patients) from blood (76.6%) or intraabdominal samples were collected and genotyped using species-specific microsatellite markers. Antifungal susceptibilities to amphotericin B, the triazoles, micafungin, anidulafungin, and ibrexafungerp were performed according to EUCAST E.Def 7.3.2; the ERG11 gene was sequenced in fluconazole-resistant isolates. A total of 13.6% (n = 48/354) isolates (one per patient) were found to be resistant to fluconazole and non-wild-type to voriconazole but fully susceptible to ibrexafungerp. Resistant isolates were mostly sourced from blood (n = 45/48, 93.8%) and were detected in five hospitals. Two hospitals accounted for a high proportion of resistant isolates (n = 41/48). Resistant isolates harbored either the Y132F ERG11p amino acid substitution (n = 43) or the G458S substitution (n = 5). Isolates harboring the Y132F substitution clustered into a clonal complex involving three genotypes (one genotype accounted for n = 39/43 isolates) that were found in four hospitals. Isolates harboring the G458S substitution clustered into another genotype found in a fifth hospital. C. parapsilosis genotypes demonstrating resistance to fluconazole have been spreading across hospitals in Madrid, Spain. Over the last 3 years, the frequency of isolation of such isolates and the number of hospitals affected is on the rise.
- Published
- 2022
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