42 results on '"Pérez de Oteyza C"'
Search Results
2. La medida del índice tobillo-brazo: particularmente indicada en pacientes con síndrome metabólico sin enfermedad arterial conocida
- Author
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Schmolling, Y., del Valle, F.J., Pérez de Oteyza, C., de Lucas, A., Brasero, F., and Fajardo, F.
- Published
- 2008
- Full Text
- View/download PDF
3. Manejo de la insuficiencia cardíaca en pacientes ancianos a través de la implantación de un hospital de día multidisciplinar
- Author
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Méndez Bailón, M., Muñoz Rivas, N., Conthe Gutiérrez, P., Ortiz Alonso, J., Pérez de Oteyza, C., and Audibert Mena, L.
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- 2007
- Full Text
- View/download PDF
4. Tuberculosis en la autopsia. Estudio anatomoclínico: análisis de 92 casos encontrados entre 2.180 autopsias
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Morales Conejo, M., Guerra Vales, J.M., Moreno Cuerda, V.J., Varona Arche, J.F., Hernando Polo, S., Palenque Mataix, E., Pérez de Oteyza, C., and Martínez Tello, F.J.
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- 2007
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- View/download PDF
5. Alteraciones de la nutrición en Medicina Interna. Análisis de la composición corporal por impedancia bioeléctrica
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García Sánchez, I., Pérez de Oteyza, C., Calvo Lasso de la Vega, E., and Castuera Gil, A.
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- 2007
- Full Text
- View/download PDF
6. Nationwide study on peripheral-venous-catheter-associated-bloodstream infections in internal medicine departments
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Guembe, M., primary, Pérez-Granda, M.J., additional, Capdevila, J.A., additional, Barberán, J., additional, Pinilla, B., additional, Martín-Rabadán, P., additional, Bouza, E., additional, Millán, J., additional, Pérez de Oteyza, C., additional, Muiño, A., additional, Villalba, M., additional, Cuenca, C., additional, Castaño, J.G., additional, Delgado, C.M., additional, Zamorano, S., additional, Gómez, B., additional, Collado, J.M., additional, Salinas, M.T., additional, Amat, A.S., additional, Lázaro, J.R., additional, del Villar Sordo, V., additional, del Valle Sánchez, M., additional, Benach, Á.F., additional, Vidal, E., additional, Albiach, L., additional, Agud Aparicio, J.M., additional, Saéz de Adana Arroniz, E., additional, Casademont i Pou, J., additional, Solchaga, V.P., additional, Castellón, F.E., additional, Obanos, T.R., additional, Egurbide Arberas, M.V., additional, Arana, J.N., additional, López, E.G., additional, Gaviria, A.Z., additional, Clemente, I.N., additional, Ruíz, P.C., additional, Salomó, A.C., additional, Iftimie, S.M., additional, Castillo, A.M., additional, Barberá Farré, J.R., additional, Lavería, A.O., additional, Ribera, M.C., additional, Pallarés, N.B., additional, Suárez, P.C., additional, Cepeda Piorno, F.J., additional, Andrés, N.A., additional, Rodríguez Tarazona, R.E., additional, Rodríguez Zapata, M.M., additional, and Costa Cerdá, M.A., additional
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- 2017
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7. Lipid profile in untreated HIV positive patients: HIV infection: cardiovascular risk factor?
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Baza Caraciolo, B., Pérez de Oteyza, C., Carrió Montiel, D., Carrió Montiel, J. C., Salguero Aparicio, M., and Romero Guerrero, J. del
- Subjects
Riesgo cardiovascular ,Lípidos ,VIH ,HIV ,lipids (amino acids, peptides, and proteins) ,Cardiovascular risk ,Lipids - Abstract
Introducción: La publicación de casos de pacientes VIH (+) con enfermedad vascular inexplicada, ha puesto en marcha múltiples estudios para tratar de conocer si los pacientes VIH (+) presentan un incremento del Riesgo Cardiovascular (RCV). Nos hemos propuesto: caracterizar el perfil lipídico de pacientes VIH (+) no tratados comparándolo con el que presentan sujetos VIH (-) y valorar si alguna de las alteraciones halladas influye de forma directa sobre la estimación del RCV. Pacientes y métodos: 407 varones homosexuales: 251 VIH (+) no tratados, y 156 VIH (-). Determinaciones bioquímicas: colesterol total (COL), HDL-colesterol (HDL), VLDL-colesterol, LDL-colesterol (LDL), triglicéridos (TG), apolipoproteínas A1 y B (ApoA1 y ApoB) y Lipoproteína a. Cocientes de aterogénicos: COL/HDL, LDL/HDL y log (TG/HDL). Los pacientes VIH (+) se dividieron en 3 grupos según recuento de linfocitos CD4. Resultados: Los pacientes VIH (+) presentaron COL, HDL, y ApoA1 menores y cocientes de RCV mayores. Estas diferencias también se mostraron entre cada grupo de pacientes VIH (+) según recuento de CD4 y el grupo control VIH (-). Un 76% de los pacientes VIH (+) presentaban concentraciones bajas de HDL (menor de 40 mg/dL), frente a un 31% de los sujetos VIH (-). Conclusiones: El perfil lipídico de los pacientes VIH (+) no tratados difiere del que presentan sujetos VIH (-). Desde los estadios mas inmunoconservados de la infección existe una disminución marcada del HDL, paralela a la disminución de ApoA1 que se mantiene a lo largo de todos los niveles de CD4. El descenso de HDL en la infección VIH multiplica el RCV global de los sujetos infectados, independientemente de la presencia de otros factores de riesgo. Introduction: Some cases of HIV (+) patients with unexplained vascular disease have been reported and many studies are being performed to determine whether HIV infected individuals have an increased cardiovascular risk (CVR). We propose: to describe lipid profile of untreated HIV (+) patients and to compare it with the HIV (-) and to assess whether any of the lipid abnormalities influence in CVR estimation. Material and Methods: 407 homosexual males: 251 untreated HIV (+), and 156 HIV (-). Biochemistry parameters: Total Cholesterol (CHOL), HDL-Cholesterol (HDL), VLDL-Cholesterol, LDL-Cholesterol (LDL), Triglycerides (TG), Apolipoproteins A1 and B (ApoA1 y ApoB) and Lipoprotein a. Atherogenic rates: CHOL/HDL, LDL/HDL and log (TG/HDL). HIV (+) patients were classified into three groups according to CD4 lymphocytes number. Results: HIV (+) patients had lower CHOL, HDL, and ApoA1 and higher CVR rates. These differences showed also between each HIV (+) group according to CD4 number and control group HIV (-). 76% of the HIV (+) patients showed low levels of HDL (less than 40 mg/dL) as compared with 31% of HIV (-) subjects. Conclusion: Untreated HIV(+) patients’ lipid profile is different from the HIV (-) subjects’ one. There are decreases in HDL and Apo A1 from the beginning of the infection that persist along all the CD4 levels. HDL decrease in HIV infection multiplies global CVR in HIV infected individuals, independently of other risk factors.
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- 2007
8. Estudio epidemiológico de la tuberculosis en un hospital de tercer nivel en el año 2001
- Author
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García Sánchez, I., Pérez de Oteyza, C., and Gilsanz Fernández, C.
- Subjects
Infección VIH ,Inmigración ,Tuberculosis ,Immigration ,HIV infection ,Factores epidemiológicos ,Epidemiological factors - Abstract
Objetivos: Estimar la incidencia y características clínicoepidemiológicas de la Tuberculosis (TB), analizando la influencia de factores predisponentes como la infección VIH, la inmigración, enfermedades crónicas y hábitos de vida. Material y métodos: Se realizo un estudio retrospectivo de los pacientes diagnosticados de TB activa (confirmación microbiológica) y latente (presencia de Mantoux positivo) durante el año 2001, en el hospital Gregorio Marañón. Las variables incluidas se referían a datos epidemiológicos, bacteriológicos, clínicos y terapéuticos. Resultados: Se detectaron 78 pacientes con TB en hospital, con una incidencia estimada en el área de salud de 11,14 casos por 100.000 habitantes. La edad media fue de 41,98 años; con 43,6% pacientes VIH positivos y 9% inmigrantes. La muestra microbiológica más utilizada fue el esputo, detectándose resistencias en 30% de los casos donde se realizo. De los 78 casos revisados, 64 (82%) tenían TB activa. En los pacientes VIH fue más frecuente la TB por reactivación (p = 0,016). La localización predominante fue la pulmonar (78%). El hallazgo radiológico más frecuente fue un infiltrado pulmonar. El 56% de los pacientes VIH presentaron radiografías normales (p 0,01). La mortalidad global fue del 9%. Conclusiones: En la actualidad, en Madrid, la población con mayor riesgo de TB son los sujetos con infección VIH, drogadicción, inmigrantes y ancianos institucionalizados. Para un adecuado control de la enfermedad es necesario un diagnóstico precoz y una supervisión del tratamiento. Objectives: Estimate the incidence and epidemiological and clinical characteristics of Tuberculosis (TB), analyzing the influence of factors such as: HIV infection, immigration, chronic diseases and styles of life. Material and methods: Retrospective study of patients who have diagnosed of active TB (microbiological results positive) and latent tuberculosis (Mantoux positive) during the year 2001 in the Gregorio Marañon Hospital. The variables includes epidemiological, microbiological, clinicals and therapeutics features. Results: We were registered 78 patients with TB at hospital, with estimated incidence in health area of 11,14 cases per 100.000 habitants. The mean age of were 41,98 years; with 43,6% HIV infected patients and 9% immigrants. The sputum was the sample most used for the microbiological diagnosis, we detected resistance in 30% of samples analysed. The HIV infected patients had more frequent TB from reactivation (p=0,016). The primary site of disease was pulmonary (78%). One pulmonary infiltrate was more frequent in the thoracic X-ray. The 56% of our HIV infected patients had normal thoracic X-ray (p
- Published
- 2005
9. Estudio epidemiológico y clínico de los pacientes diagnosticados de tuberculosis en el área noroeste de Madrid
- Author
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Vieira Pascual, M. C., Bischofberger, C., and Pérez de Oteyza, C.
- Subjects
Epidemiological ,Inmigración ,Tuberculosis ,Epidemiología ,Immigration - Abstract
Objetivo: Estimar la incidencia y las características epidemiológicas y clínicas de los pacientes diagnosticado de Tuberculosis en un hospital comarcal de área noroeste de Madrid, para determinar si existe un aumento de la incidencia debido a la inmigración. Material y métodos: Se revisaron los casos de tuberculosis desde Enero de 1996 a Junio del 2001, buscados a través del laboratorio de anatomía patológica y microbiología, recogiendo de las historias clínicas datos demográficos, clínicos y diagnósticos de la enfermedad. Resultados: Se registraron un total de 66 tuberculosis (10 de ellos en inmigrantes) con una incidencia del 13/100.000 habitantes en el 1996, descendiendo hasta una incidencia del 7/100.000 en el 2000. La mediana de la edad es de 34 años con una incidencia del doble en varones (31/100.000 habitantes) respecto a las mujeres (17/100.000). El factor de riesgo predominante es el alcoholismo con 11 casos (16.7%). Las pruebas diagnosticas más empleadas fueron la radiografía de tórax realizada en 61/66 (92%) y fue positiva en 57 (93,4%), BAAR 59 (89%) siendo positiva 34 (57,6%), cultivo de esputo 47 (71%) dando positiva 32 (68%) y el Mantoux 28 (42%) siendo positiva 20 (71.4%). La localización de la enfermedad es principalmente pleuro-pulmonar 50 casos (75%). No se tipificaron prácticamente mycobacterias atípicas (5 casos). Hubo una buena respuesta al tratamiento siendo tratados con tres fármacos (isoniacida, rifampicina y piracinamida) el 88% de los pacientes con un tiempo de duración de 6,8 meses (DE: 2,8). Conclusión: La incidencia de tuberculosis en el área noroeste de Madrid es inferior al resto de la Comunidad de Madrid, descendió en el 1997 y se ha mantenido en el 9/100.000 hasta el 2000 pese al aumento de la inmigración. Objective: Estimate the incidence and the epidemiological and clinical characteristics of patients diagnosed with tuberculosis in a county hospital located in the north western area of the Autonomous Region of Madrid, to determine if there has been an increase due to immigration. Material and methods: Tuberculosis cases from January, 1996 to June, 2001 were analysed, researched through the Microbiology and Pathologic Anatomy Laboratory, fetching information such as demographics, clinical studies and disease diagnostics from the different medical histories. Results: A total of 66 tuberculosis cases were registered, ten of them among immigrants, with an incidence of 13/100.000 inhabitants in 1996, decreasing to a 7/100.000 incidence in 2000. The age average is 34 with double the incidence in males (31/100.000) than females (17/100.000). The main risk factor is alcoholism with 11 cases (16.7%). The most commonly used diagnostic tests were the thorax radiography (61/66, 92%) with 57 (93.4%) positive identifications, culture of esputo (47/66, 71%) with 32 (68%) positive ids, and the Mantoux test (28, 42%) with 20 (71.4%) positive ids. The location of the illness is mainly pleuro-pulmonar in 50 cases (75%). There were almost no atypical mycobacterium found (5 cases). Overall, response to treatment with 3 drugs (isoniacide, rifampicine, piracinamide) was good in 88% of patients, with the average treatment lasting 6.8 months (ED: 2.8). Conclusion: The incidence of tuberculosis in the north western area of Autonomous Community of Madrid is below that of the rest of our Community. It dipped in 1997 and has been stable around 9/100.000 inhabitants until 2000, even with the effect of immigration.
- Published
- 2003
10. Perfil lipídico en pacientes VIH (+) no tratados: Infección VIH: ¿factor de riesgo cardiovascular?
- Author
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Baza Caraciolo, B., primary, Pérez de Oteyza, C., additional, Carrió Montiel, D., additional, Carrió Montiel, J. C., additional, Salguero Aparicio, M., additional, and Romero Guerrero, J. del, additional
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- 2007
- Full Text
- View/download PDF
11. Fiebre y lesión muscular del pectoral mayor
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García Sánchez, I., primary, Pérez de Oteyza, C., additional, Gilsanz Fernández, C., additional, and Audibert, L., additional
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- 2006
- Full Text
- View/download PDF
12. Estudio epidemiológico de la tuberculosis en un hospital de tercer nivel en el año 2001
- Author
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García Sánchez, I., primary, Pérez de Oteyza, C., additional, and Gilsanz Fernández, C., additional
- Published
- 2005
- Full Text
- View/download PDF
13. Estudio epidemiológico y clínico de los pacientes diagnosticados de tuberculosis en el área noroeste de Madrid
- Author
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Vieira Pascual, M. C., primary, Bischofberger, C., additional, and Pérez de Oteyza, C., additional
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- 2003
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- View/download PDF
14. Mo-P1:59 Control of cardiovascular risk factors in type 2 diabetes mellitus in primary care
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Mantilla, T., Perez De Oteyza, C., Gomez De La Camara, A., Alvarez-Sala, L., and Alonso De Caso, M.D.
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- 2006
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15. [Ankle-brachial index testing is particularly indicated in patients with metabolic syndrome but without known arterial disease].
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Schmolling Y, Del Valle FJ, Pérez de Oteyza C, de Lucas A, Brasero F, and Fajardo F
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- Aged, Ankle, Arm, Blood Pressure Determination methods, Cross-Sectional Studies, Female, Humans, Male, Metabolic Syndrome epidemiology, Middle Aged, Peripheral Vascular Diseases diagnosis, Peripheral Vascular Diseases etiology, Risk Assessment, Cardiovascular Diseases diagnosis, Cardiovascular Diseases etiology, Metabolic Syndrome complications
- Abstract
Introduction: The objective was to investigate the prevalence of metabolic syndrome (MetS), its cardiovascular disease (CVD) risk and its association with peripheral arterial disease, defined by a low ankle-brachial index (ABI) (< 0.90), in primary prevention., Material and Methods: Cross-sectional study performed in the primary care general population, aged 50-79 years. CVD risk and ABI were measured in persons without known arterial disease with MetS and in a control group. MetS was defined by Adult Treatment Panel III. CVD risk was estimated using the Systematic Coronary Risk Evaluation (SCORE)., Results: A total of 581 subjects were recruited. The prevalence of the metabolic syndrome was 30.8% (95% confidence interval [CI], 27.0-34.5). For the CVD risk and ABI studies 217 individuals were included (138 with MetS and 49 with diabetes). Average CVD risk was high (5%) on patients with MetS and twice as much as those without MetS. ABI was low (< 0.90) on 15 subjects [6.9% (95% CI), 3.5-10.2], with higher frequency in the MetS group: 14 patients (10.1%) vs 1 patient (1.3%). The frequency of low ABI in patients with and without diabetes was 18.3% and 3.6% respectively. Low ABI was associated to MetS, diabetes, inactivity, high risk of SCORE and less alcohol habit. In the multivariate analysis, the odds ratio for the association MetS/low ABI was 14.7 (95% CI, 1.7-123.6)., Conclusion: MetS is related to asymptomatic peripheral arterial disease. Thus, the measure of ABI in those patients with this syndrome is recommended.
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- 2008
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16. [Lipid profile in untreated HIV positive patients. HIV infection: cardiovascular risk factor?].
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Baza Caraciolo B, Pérez de Oteyza C, Carrió Montiel D, Carrió Montiel JC, Salguero Aparicio M, and Del Romero Guerrero J
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- Adult, CD4 Lymphocyte Count, Cardiovascular Diseases etiology, Cholesterol blood, Cholesterol, HDL blood, Data Interpretation, Statistical, Homosexuality, Male, Humans, Male, Risk Factors, Triglycerides blood, HIV Seronegativity, HIV Seropositivity blood, Lipids blood
- Abstract
Introduction: Some cases of HIV+ patients with unexplained vascular disease have been reported and many studies are being performed to determine whether HIV infected individuals have an increased cardio-vascular risk (CVR). We propose: to describe lipid profile of untreated HIV+ patients and to compare it with the HIV- and to assess whether any of the lipid abnormalities influence in CVR estimation., Material and Methods: 407 homosexual males: 251 untreated HIV+ and 156 HIV-. Biochemistry parameters: Total cholesterol (CHOL), HDL-cholesterol (HDL), VLDL-cholesterol, LDL-cholesterol (LDL), triglycerides (TG), apolipoproteins A1 and B (ApoA1 y ApoB) and lipoprotein A. Atherogenic rates: CHOL/HDL, LDL/HDL and log (TG/HDL). HIV+ patients were classified into three groups according to CD4 lymphocytes number., Results: HIV+ patients had lower CHOL, HDL, and ApoA1 and higher CVR rates. These differences showed also between each HIV+ group according to CD4 number and control group HIV-. 76% of the HIV+ patients showed low levels of HDL (less than 40 mg/dL) as compared with 31% of HIV- subjects., Conclusion: Untreated HIV+ patients' lipid profile is different from the HIV- subjects; one. There are decreases in HDL and ApoA1 from the beginning of the infection that persis along all the CD4 levels. HDL decrease in HIV infection multiplies global CVR in HIV infected individuals, independently of other risk factors.
- Published
- 2007
- Full Text
- View/download PDF
17. [Measurement of NT-proBNP in elderly patients with acute dyspnea: diagnostic and pronostic value].
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Méndez Bailón M, Muñoz Rivas N, Romero Román C, Pérez de Oteyza C, Conthe Gutiérrez P, and Audibert Mena L
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- Acute Disease, Aged, Biomarkers, Diagnosis, Differential, Dyspnea physiopathology, Electrocardiography, Female, Humans, Male, Prognosis, Risk Factors, Dyspnea diagnosis, Dyspnea metabolism, Heart Failure diagnosis, Heart Failure metabolism, Natriuretic Peptide, Brain metabolism, Peptide Fragments metabolism
- Abstract
Background and Objective: The aim of our study was to establish weather N-terminal fragment of brain-type natriuretic peptide (NT-proBNP) is useful in the differential diagnosis of dyspnea in elderly patients, and whether its determination has a prognostic value in heart failure (HF)., Patients and Method: 79 patients admitted with acute dyspnea at the emergency department were included in our study. The mean age (standard deviation) was 77.56 (8.71) years. 67% had a diagnosis of HF based on clinical and echocardiagraphic criteria. A follow-up of 18 months was performed after discharge., Results: Higher levels of NT-proBNP were found in patients with HF (6,833.54 pg/ml) than in patients with other causes of dyspnea (1,801.99 pg/ml) (p < 0.0001). A cut-off point of NT-proBNP > 730 pg/ml was related to higher rates of readmission due to HF over the next 18 months., Conclusions: NT-proBNP is a useful biomarker in the differential diagnosis of dyspnea in the elderly population. Its determination has a prognostic roll, stratifying the risk of readmission in HF patients.
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- 2007
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18. [Nutrition alterations in internal medicine. Body composition analysis with bioelectrical impedance].
- Author
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García Sánchez I, Pérez de Oteyza C, Calvo Lasso de la Vega E, and Castuera Gil A
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- Aged, Cross-Sectional Studies, Electric Impedance, Female, Humans, Internal Medicine, Male, Prevalence, Prospective Studies, Body Composition, Malnutrition epidemiology, Malnutrition physiopathology
- Abstract
Objectives: To determine the prevalence of malnutrition in patients in Internal Medicine. To describe the changes of corporal composition depending on body mass index (BMI). To evaluate validity of the different screening tools for the estimation of body composition., Material and Methods: Prospective observational cross-sectional study of the prevalence of malnutrition in 300 patients (sample 1); these were chosen 136 patients (sample 2), classifying in four groups: BMI < 20: 30 patients; BMI = 20-25: 46 patients; BMI = 25-30: 30 patients, and BMI > 30: 30 patients. In the patients of sample 2, we carried out a protocol of nutritional evaluation with anthropometry, laboratory and bioelectrical impedance analysis., Results: The prevalence of desnutrition was 9.3% and the obesity was 22.3%. In undernourished patients, the measure of body compartments with bioelectrical impedance, expressed in percentage of body weight, were: fat mass 20.5%, fat-free mass 79.4% and total body mater 58.3%. The body composition in obeses was: fat mass 40.1%, fat-free mass 60.6% and total body water 44.3%. The patients with normal BMI, the meta index (impedance at 50 kHz/BMI) was 25.9 +/- 5.21; in undernourished the index was higher (36.7) and obeses lower (15.5). The meta index (30-20) estimates desnutrition-obesity with high sensibility and specificity. The prevalence of desnutrition varies from 6% to 69% and obesity from 23% to 74%, using different methods and criterions for the estimation of body composition., Conclusions: In Internal Medicine, the overweight (BMI > 25) is the most prevalent nutritional alteration. The bioelectrical impedance analysis helps for estimation of body composition and meta index is a very useful indicator of malnutrition (desnutrition-obesity).
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- 2007
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19. [Fever and pectoralis major muscle lesion].
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García Sánchez I, Pérez de Oteyza C, Gilsanz Fernández C, and Audibert L
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- Female, Fever etiology, Humans, Middle Aged, Pectoralis Muscles pathology, Polyarteritis Nodosa diagnosis
- Published
- 2006
- Full Text
- View/download PDF
20. [Tuberculosis epidemiological study in a third level hospital during 2001].
- Author
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García Sánchez I, Pérez de Oteyza C, and Gilsanz Fernández C
- Subjects
- Adult, Anti-Bacterial Agents, Antitubercular Agents therapeutic use, Comorbidity, Drug Therapy, Combination therapeutic use, Emigration and Immigration statistics & numerical data, False Negative Reactions, HIV Infections epidemiology, Hospitals, General statistics & numerical data, Hospitals, University statistics & numerical data, Humans, Incidence, Middle Aged, Mycobacterium tuberculosis isolation & purification, Radiography, Retrospective Studies, Spain epidemiology, Tuberculosis drug therapy, Tuberculosis microbiology, Tuberculosis, Multidrug-Resistant epidemiology, Tuberculosis, Pulmonary diagnostic imaging, Tuberculosis, Pulmonary epidemiology, Tuberculosis epidemiology
- Abstract
Objectives: Estimate the incidence and epidemiological and clinical characteristics of Tuberculosis (TB), analyzing the influence of factors such as: HIV infection, immigration, chronic diseases and styles of life., Material and Methods: Retrospective study of patients who have diagnosed of active TB (microbiological results positive) and latent tuberculosis (Mantoux positive) during the year 2001 in the Gregorio Marañon Hospital. The variables include epidemiological, microbiological, clinical and therapeutic features., Results: We registered 78 patients with TB at hospital, with estimated incidence in health area of 11, 14 cases per 100,000 habitants. The mean age of were 41.98 years; with 43.6% HIV infected patients and 9% immigrants. The sputum was the sample most used for the microbiological diagnosis, we detected resistance in 30% of samples analyzed. The HIV infected patients had more frequent TB from reactivation (p=0,016). The primary site of disease was pulmonary (78%). One pulmonary infiltrate was more frequent in the thoracic X-ray. The 56% of our HIV infected patients had normal thoracic X-ray (p <0,05). The treatment more common was with four drugs and the 75% of our patients fulfilled the treatment; the HIV infected patients leaves the treatment more frequent. The global mortality was 9%., Conclusions: Actually, in Madrid, the persons with HIV infection, injection drug abuse, immigration and elders in residential home were higher risk of infection for TB. For strict control of disease is need early diagnosis and supervision of treatment .
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- 2005
- Full Text
- View/download PDF
21. [Epidemiological and clinical study of patients diagnosed with tuberculosis in the northeastern area of Madrid].
- Author
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Vieira Pascual MC, Bischofberger C, and Pérez de Oteyza C
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- Adolescent, Adult, Aged, Aged, 80 and over, Emigration and Immigration statistics & numerical data, Female, Humans, Incidence, Male, Middle Aged, Retrospective Studies, Spain, Tuberculosis drug therapy, Urban Health, Tuberculosis diagnosis, Tuberculosis epidemiology
- Abstract
Objective: Estimate the incidence and the epidemiological and clinical characteristics of patients diagnosed with tuberculosis in a county hospital located in the north western area of the Autonomous Region of Madrid, to determine if there has been an increase due to immigration., Material and Methods: Tuberculosis cases from January, 1996 to June, 2001 were analysed, researched through the Microbiology and Pathologic Anatomy Laboratory, fetching information such as demographics, clinical studies and disease diagnostics from the different medical histories., Results: A total of 66 tuberculosis cases were registered, ten of them among immigrants, with an incidence of 13/100,000 inhabitants in 1996, decreasing to a 7/100,000 incidence in 2000. The age average is 34 with double the incidence in males (31/100,000) than females (17/100,000). The main risk factor is alcoholism with 11 cases (16.7%). The most commonly used diagnostic tests were the thorax radiography (61/66, 92%) with 57 (93.4%) positive identifications, culture of esputo (47/66, 71%) with 32 (68%) positive ids, and the Mantoux test (28, 42%) with 20 (71.4%) positive ids. The location of the illness is mainly pleuro-pulmonar in 50 cases (75%). There were almost no atypical mycobacterium found (5 cases). Overall, response to treatment with 3 drugs (isoniacide, rifampicine, piracinamide) was good in 88% of patients, with the average treatment lasting 6.8 months (ED: 2.8)., Conclusion: The incidence of tuberculosis in the north western area of Autonomous Community of Madrid is below that of the rest of our Community. It dipped in 1997 and has been stable around 9/100,000 inhabitants until 2000, even with the effect of immigration.
- Published
- 2003
22. [Antiretroviral drug resistance].
- Author
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Menéndez MA and Pérez de Oteyza C
- Subjects
- Anti-HIV Agents therapeutic use, Female, Genes, Viral, HIV genetics, HIV physiology, HIV Infections drug therapy, Humans, Male, Microbial Sensitivity Tests methods, Microbial Sensitivity Tests statistics & numerical data, Practice Guidelines as Topic, Pregnancy, Pregnancy Complications, Infectious drug therapy, Spain, Virus Replication drug effects, Virus Replication genetics, Anti-HIV Agents pharmacology, Drug Resistance, Microbial genetics, HIV drug effects
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- 2001
- Full Text
- View/download PDF
23. [Cryptogenic cirrhosis?].
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González Hernández C, Pintor Escobar A, Pallarés Fernández JM, Caballero A, and Pérez de Oteyza C
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- Adult, Hepatolenticular Degeneration diagnosis, Humans, Male, Liver Cirrhosis diagnosis
- Published
- 1999
24. [Pleurisy in an aged patient: a rare presentation of systemic lupus erythematosus].
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Barberán López J, Khorrami Mashhadi S, Sánchez Artola B, Menéndez MA, and Pérez de Oteyza C
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- Aged, Diagnosis, Differential, Female, Humans, Lupus Erythematosus, Systemic complications, Pleural Effusion diagnosis, Pleural Effusion etiology, Pleurisy diagnosis, Lupus Erythematosus, Systemic diagnosis, Pleurisy etiology
- Published
- 1999
25. [Discriminative value for AIDS case of erythrocyte sedimentation rate, immunoglobulins IgA and IgM, and beta 2-microglobulin in combination with the CD4+ lymphocyte count].
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Pérez de Oteyza C, Menéndez Martínez MA, Muro García R, Pérez Aznar C, and Barberán López J
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- Adolescent, Adult, Aged, Blood Sedimentation, CD4 Lymphocyte Count, Discriminant Analysis, Disease Progression, Female, Humans, Immunoglobulin A blood, Immunoglobulin M blood, Male, Middle Aged, beta 2-Microglobulin analysis, Acquired Immunodeficiency Syndrome immunology, HIV Infections physiopathology
- Abstract
Objective: To establish the probability to discriminate the evolution to "AIDS case" in relation to the common laboratory parametres in the follow-up of the HIV infection., Material and Methods: We have studied a cohort of 118 patients (1986-95) with HIV infection, 14 of them (12%) had clinical criteria for AIDS (CDC/93) during the follow-up. Clinical evaluations and CD4+ and CD8+ lymphocytes, beta 2M, IgG, IgA, IgM and E.S.R determinations were done. Multivariate analysis (RSIGMA) was done. with the initial laboratory values, according to the clinical diagnostic (AIDS and NO AIDS) done during the follow-up., Results: By multiple logistic regression those laboratory variables with more predictor value for "AIDS CASE" were selected. With the initial value of these variables (E.S.R., beta 2M, IgA, IgM and CD4+ lymphocytes) and the clinical diagnostic of AIDS done during the follow-up, we did the linear discriminatory analysis between two groups (AIDS, NO AIDS) obtaining generalized distance between both groups of 3,4609 and a probability of classification error of 4%. A very significant difference (p < 0.001) was obtaining when we compare the variables' mean of each of the clinical groups., Conclusion: In the HIV infection the values of ESR, beta 2M, IgA and IgM in combination with the absolute value of the CD4+ lymphocytes allows to discriminate those patients who will develop AIDS with a probability of classifications error of 4%. This has clinical interest in absence of viral load and helps to take therapeutical decisions.
- Published
- 1998
26. [Megestrol in the treatment of AIDS associated cachexia. Evaluation by bioelectric impedance analysis of body composition].
- Author
-
Pérez De Oteyza C, García Cortés A, Menéndez Martínez MA, Torres Léon JM, Pérez Aznar C, and Carnicero Bujarrabal M
- Subjects
- Adult, Body Composition, Electric Impedance, Female, Humans, Male, Middle Aged, Appetite Stimulants therapeutic use, HIV Wasting Syndrome drug therapy, Megestrol Acetate therapeutic use, Progesterone Congeners therapeutic use
- Abstract
Objective: To value the effects of megestrol acetate wer the weight and the body composition (fat, lean and body water) in patients with AIDS associated cachexia, by bioelectric impedance analysis., Subjects: 25 patients between 23 and 57 years of age, with confirmed HIV infection and prior weight lost of 7.96 +/- 4.6 kg in relation to their habitual weight in the previous months. All the patients were under antiretroviral therapy., Method: Basal determination, before the beginning of the antianorexic treatment and at the end of it, using bioelectric impedance analysis by Maltron BF 905 analyzer, calculating fat, lean and total body water in relation to weight, height, age and sex. Oral administration of 320 mg/day megestrol acetate for three consecutive months. Statistical comparation (RSIGMA and SPSS) by paired t-test of the mean weight, body mass index, fat, lean and total body water., Results: During the three months treatment the mean basal body weight of the patients increased 3.54 Kg (p < 0.001) at the expense of an increase of 2.24 kg in the total body lean (p < 0.01), while the increment of the body fat (1.2 kg) was not statistically significant. The total body water increased 1.48 L (p < 0.001) and the body mass index in 1.22 kg/m2 (p < 0.001)., Conclusion: Treatment with megestrol acetate results in a substained and very significant increase of the weight and body mass index in patients with AIDS related cachexia. This increment in weight is at the expense of body lean.
- Published
- 1998
27. [Differences in laboratory parameters in clinical categories (CDC/93) of HIV infection].
- Author
-
Menéndez Martínez MA, Pérez De Oteyza C, Muro García R, García Cortés A, and Pastor Gómez JM
- Subjects
- Acquired Immunodeficiency Syndrome blood, Acquired Immunodeficiency Syndrome classification, Acquired Immunodeficiency Syndrome immunology, Adolescent, Adult, Aged, Analysis of Variance, Disease Progression, Female, HIV Infections blood, HIV Infections immunology, Humans, Male, Middle Aged, Prospective Studies, HIV Infections classification
- Abstract
Objective: To establish the difference between the evolutive clinical categories (CDC/93) of the HIV infection, on the basis of diverse laboratory parameters., Material and Method: 332 samples of blood, from 118 patients with HIV infection revised every three months from 1986, were studied. Determinations: haematologic, biochemical and immunologic study. Classification in each review by CDC/93 system. Statistical analysis (R-SIGMA) comparing by ANOVA and NEWMANN-KEULS the averages of the laboratory variables in the clinics categories ("A", "B" and "C")., Results: There are very significant laboratory differences (p < 0.01) between the asymptomatic patients ("A") and the AIDS cases ("C"), with important decrease of hemoglobin, platelets, leukocytes, albumin, CD4+ and CD8+ T cells in the "C" category. On the contrary there is a marked increase of erythrocyte sedimentation, triglycerides, immunoglobulin A and beta 2-microglobulin in those patients with AIDS., Conclusion: AIDS patients present very significant differences in ten laboratory parameters, compared to the asymptomatic HIV infected patients. The follow up of these parameters may have prognostic value of AIDS evolution and be useful for the therapeutic decision making.
- Published
- 1997
28. [Adenosine deaminase (ADA) and beta 2-microglobulin (beta 2M) as discriminating serum markers of progression to AIDS].
- Author
-
Pérez de Oteyza C, Menéndez Martínez MA, Irazábal C, Enríquez de Salamanca R, Pérez Aznar C, and Rebollar JL
- Subjects
- Adult, Analysis of Variance, Biomarkers blood, Cohort Studies, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Acquired Immunodeficiency Syndrome diagnosis, Adenosine Deaminase blood, Clinical Enzyme Tests statistics & numerical data, HIV Infections diagnosis, HIV-1, beta 2-Microglobulin analysis
- Abstract
Background: To establish the discriminatory value of ADA and beta 2M serum levels as markers of AIDS progression., Methods: We have followed quarterly during two years a cohort of 24 patients with HIV infection; 103 clinical and laboratory evaluations were done (CDC/93 classification). In each of those blood samples we determined ADA, beta 2M, IgG, IgA, IgM, and CD4+ and CD8+ lymphocytes., Results: 26 evaluations belong to cases that kept stable in the clinic category A or B, CDC/93, ("stables": ADA = 19.05 +/- 10.79 U/L; beta 2M = 2.95 +/- 1.1 mg/L); the remaining 77 evaluations are from patients who clinical progressed to AIDS ("progressors": ADA = 32.03 +/- 13.2 U/L; beta 2M = 4.74 +/- 1.94 mg/L). When we compared statistically (RSIGMA software) the ADA and beta 2M means of both groups (Student t) and the means of all the variables in a block (multivariate analysis: Hotelling T2), very significant differences were appreciated (p < 0.001)., Conclusions: ADA and beta 2M are significantly increased in serum of HIV infected patients who clinical progress to AIDS. ADA and beta 2M can be used as serum markers of AIDS progression with a mistaken classification probability in the discriminatory analysis of 0.25; this probability decreases to 0.06 when immunoglobulins and lymphocytes subpopulations are evaluated too.
- Published
- 1996
29. [Alterations of fibrinolysis in stroke].
- Author
-
Hernández Nuñez A, Romero Barbero JL, Cáceres Sansaloni A, and Pérez de Oteyza C
- Subjects
- Adult, Age Factors, Aged, Aged, 80 and over, Cerebrovascular Disorders blood, Cerebrovascular Disorders physiopathology, Female, Fibrinogen analysis, Humans, Incidence, Male, Middle Aged, Plasminogen analysis, Sex Factors, Tissue Plasminogen Activator antagonists & inhibitors, Tissue Plasminogen Activator blood, Cerebrovascular Disorders epidemiology, Fibrinolysis physiology
- Abstract
The fibrinolytic system has an important role as a controller of the coagulation, since plasmin digests and dissolves the fibrin clot. In this way, they have described many alterations in this system that are responsible of the thromboembolic disease, moreover stroke. This study tries to show the incidence of these alterations in a group of patients suffering from stroke, and the difference of this incidence between men and women. We obtained that the fibrinogen, tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI-1) levels are significantly increased (p < 0.01) in the group of patients, and in the same way, there are also differences (p < 0.01) between men and women, so in the control group as in the patients group; these differences should mean that women have a major risk for suffering an stroke, but it doesn't fits the fact that stroke is more frequent in men and that they are younger when they suffer from this disease.
- Published
- 1996
30. [Peritoneal mesothelioma: long-course ascites as the only clinical manifestation].
- Author
-
Pérez de Oteyza C, Torres León JM, Menéndez Martínez MA, Pastor Gómez JM, García de Salazar I, and Ramírez García JR
- Subjects
- Chronic Disease, Female, Humans, Mesothelioma pathology, Middle Aged, Peritoneal Neoplasms pathology, Ascites etiology, Mesothelioma complications, Peritoneal Neoplasms complications
- Abstract
The mesothelioma is a rare tumor, especially in its peritoneal location (20%). Most of these cases are related to an exposition to asbestos long time age. We present a patient with long-evolution ascites and without any other clinical manifestations. The study of the ascitic fluid, the imaging techniques and the peritoneoscopy did not allow the diagnosis in the first place. Only after one year of follow-up and when the patient recalled, in a directed interrogation, her occupational contact with asbestos thirty years age, the diagnosis could be established.
- Published
- 1994
31. [HIV infection at the Central Military Hospital of Madrid].
- Author
-
Menéndez Martínez MA, Pérez de Oteyza C, Pastor Gómez JM, Muro García R, Carrillo Largaespada O, and Villanueva Serrano S
- Subjects
- Adolescent, Adult, Aged, Analysis of Variance, Female, HIV Infections classification, Hospitals, Military, Humans, Male, Middle Aged, Prospective Studies, Spain, HIV Infections epidemiology
- Abstract
Unlabelled: We describe the infection by HIV observed in the scope of the Military Hospital and we evaluate the clinical usefulness of the current classification systems. We have retrospectively studied (1986-1993) 80 confirmed cases of infection by HIV: 21 women and 59 men (age range: 17-65 years). Quarterly clinico-biological controls. Initial and final classification according to CDC 87/93 systems., Statistical Analysis: RSIGMA. We have detected in 26% of the patients heterosexual contagion; in 55%, toxicomania and in 17%, homosexuality; 39% had less than 200 CD4/microL upon admission. During the follow-up, 35 patients fulfilled AIDS criteria (17% due to tuberculosis); 17 died (21%) and 30 gave up (37%)., Conclusions: HIV infection is less frequent in the military sociofamiliar environment, with lower incidence of tuberculosis. There is a greater proportion of women, heterosexual transmission and asymptomatic patients. CDC-93 classification is the system best adapted to the natural history of the HIV infection.
- Published
- 1994
32. [Antiphospholipid antibodies in megakaryocytic thrombopenias].
- Author
-
Pérez de Oteyza C, López Valero I, Romero Barbero JL, Marcos Herrero E, and Muro García R
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Autoimmune Diseases classification, Autoimmune Diseases epidemiology, Autoimmune Diseases etiology, Autoimmune Diseases immunology, Female, Humans, Male, Middle Aged, Prevalence, Prognosis, Spain epidemiology, Thrombocytopenia classification, Thrombocytopenia epidemiology, Thrombocytopenia etiology, Antibodies, Antiphospholipid blood, Megakaryocytes immunology, Thrombocytopenia immunology
- Abstract
We investigated the prevalence of antiphospholipid antibodies (APA) in megakaryocytic thrombopenias in order to establish their clinical significance and prognostic value. We studied 82 thrombopenic patients: 38 women and 44 men (age: 17-91 years). We assessed circulating lupus antibody (LA) through thromboplastin inhibition test (TIT), anticardiolipin antibodies (ACL) through ELISA and antiplatelet antibodies through flow cytometer. We conducted a statistical study RSIGMA, comparing patients with ACL + against ACL-. We found ACL positive in 21%, LA in 33% and antiplatelet antibodies in 42%. We observed a direct correlation (p < 0.05) between ACL and LA and between ACL and anticore antibodies, but not between ACL and antiplatelet antibodies. There was also a significant correlation between ACL and abortion, thrombosis and bleeding in thrombopenic patients. We conclude that APAs are present in 39% of the megakaryocytic thrombopenias and that they are not correlated with antiplatelet antibodies. Positivity of APA in thrombopenic patients is associated to poor prognosis and long term follow-up.
- Published
- 1994
33. [Maxillary sinus lymphoma associated with HIV infection].
- Author
-
Ménendez Martínez MA, Pérez de Oteyza C, Pastor Gómez JM, Brinquis MA, Moratinos P, Marcos Herreros E, and Arjona C
- Subjects
- Adult, Humans, Male, Tomography, X-Ray Computed, Lymphoma, AIDS-Related diagnostic imaging, Lymphoma, Large-Cell, Immunoblastic diagnostic imaging, Maxillary Sinus Neoplasms diagnostic imaging
- Abstract
We present the case of a patient with positive antibodies against the human immunodeficiency virus, erroneously diagnosed, on the basis of conventional radiology and clinical signs, as right maxillary sinusitis. CT showed a tumoral mass at the maxillary sinus, with histology of highly malignant Non-Hodgkin's Lymphoma (NHL). The chemotherapy (CHOP) resulted in clinical remission, but the appearance of acute myelodepression forced the staggering of cycles, resulting in recurrency of the disease. The addition of G-CSF allowed to continue chemotherapy at full doses, again with positive responses. The lymphoma located at the maxillary sinus is extremely rare in patients with AIDS. Chemotherapy is complicated by myelodepression and the frequent development of opportunistic infections. The use of stimulant factors of the hematopoietic growth facilitates the management of AIDS-associated neoplasias.
- Published
- 1994
34. [The usefulness and limitations of adenosine deaminase in the diagnosis of tubercular pleurisy. A meta-analytical study].
- Author
-
Ena J, Valls V, Pérez de Oteyza C, and Enríquez de Salamanca R
- Subjects
- Humans, Meta-Analysis as Topic, Prevalence, Prognosis, Risk Factors, Tuberculosis, Pleural epidemiology, Adenosine Deaminase blood, Clinical Enzyme Tests, Tuberculosis, Pleural diagnosis
- Abstract
To assess the yield of adenosine deaminase (ADA) measurement in the diagnosis of tuberculous pleuritis and to afford parameters applicable to different populations and risk groups, a meta-analysis was performed in this study. National and anglo-saxon studies included in the Index Medicus from 1980 to march of 1990 were reviewed. The estimated incidence of tuberculous pleuritis in our medium was about 0.18 (confidence intervals for 95%-95% CI: 15-0.21). The diagnostic yield of ADA was as follows: sensitivity of 0.99 (95% CI: 0.98-0.99) and specificity of 0.93 (95% CI: 0.91-0.94). The quotients of probability (parameters that measure the predictive values of the tests at any given prevalence) were 14.31 and 0.004 for the positive and negative tests, respectively. In or medium the positive and negative predictive values were 0.74 (95% CI: 0.68-0.81) and 0.99 (95% CI: 0.98-0.99), respectively. An ADA value below the discriminative level nearly rules out the existence of tuberculous pleuritis, whereas at the contrary, and ADA value above the discriminative point offers a limited information about the etiology of the pleural effusion.
- Published
- 1990
35. [Etiopathogenesis of alcoholic pancreatitis].
- Author
-
Pérez de Oteyza C and Rebollar Mesa JL
- Subjects
- Humans, Alcoholism complications, Pancreatitis etiology
- Published
- 1980
36. [Epigastric pain and hematemesis in an elderly patient].
- Author
-
Martín Peinador A, Muñoz González A, Pérez de Oteyza C, and Aragoncillo Ballesteros P
- Subjects
- Aged, Esophageal Perforation complications, Humans, Male, Pleural Effusion diagnostic imaging, Radiography, Esophageal Perforation diagnosis, Hematemesis etiology, Pain etiology, Stomach
- Published
- 1986
37. [Budd-Chiari syndrome caused by membranous obstruction of the inferior cava and circulating anticoagulant].
- Author
-
Pérez de Oteyza C, Carnicero M, Madrigal J, Gallego J, Escrivá A, Téllez G, O'Connor F, García Calvo MI, and Rebollar JL
- Subjects
- Adult, Blood Coagulation Factors analysis, Blood Coagulation Factors antagonists & inhibitors, Budd-Chiari Syndrome blood, Budd-Chiari Syndrome surgery, Female, Humans, Lupus Coagulation Inhibitor, Budd-Chiari Syndrome etiology, Vena Cava, Inferior abnormalities
- Published
- 1983
38. [Respiratory changes in acute pancreatitis].
- Author
-
Pérez de Oteyza C, Marín Ferrer JM, Rebollar JL, Ballarín M, Chantres MT, and Rosso C
- Subjects
- Acute Disease, Adult, Aged, Blood Gas Analysis, Female, Humans, Lung diagnostic imaging, Male, Middle Aged, Radiography, Lung Diseases etiology, Pancreatitis complications, Pleural Diseases etiology
- Published
- 1981
39. [Pneumopericardium and pericarditis caused by gastropericardial fistula. An unnusual complication of peptic ulcer].
- Author
-
Rosso Manzanares C, Pérez de Oteyza C, Rebollar Mesa J, Martínez Martínez A, and Torrado Cadenas J
- Subjects
- Aged, Diagnosis, Differential, Female, Gastric Fistula etiology, Hernia, Hiatal complications, Hernia, Hiatal diagnostic imaging, Humans, Peptic Ulcer diagnostic imaging, Pericarditis diagnostic imaging, Pneumopericardium diagnostic imaging, Radiography, Gastric Fistula complications, Peptic Ulcer complications, Pericarditis etiology, Pneumopericardium etiology
- Published
- 1980
40. [Controlled treatment of acute pancreatitis. Double-blind trial with cimetidine].
- Author
-
Pérez de Oteyza C, Rebollar JL, Ballarin M, Chantres MT, Alonso A, Marin J, García Calvo MI, Gonzálex Pérez J, and Gilsanz V
- Subjects
- Acute Disease, Clinical Trials as Topic, Double-Blind Method, Drug Evaluation, Humans, Placebos, Cimetidine therapeutic use, Guanidines therapeutic use, Pancreatitis drug therapy
- Published
- 1980
41. [Adenosine deaminase in pleural effusions. Its usefulness in the diagnosis of tuberculous pleurisy].
- Author
-
Pérez de Oteyza C, Chantres MT, Rebollar JL, Muñoz Yañez MC, García Marcos F, Pérez Barba M, and Enríquez de Salamanca R
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Evaluation Studies as Topic, Female, Humans, Male, Middle Aged, Neoplasms complications, Pleural Effusion etiology, Pneumonia complications, Predictive Value of Tests, Sensitivity and Specificity, Tuberculosis, Pleural complications, Adenosine Deaminase analysis, Pleural Effusion enzymology, Tuberculosis, Pleural diagnosis
- Abstract
The activity of adenosine deaminase was determined in 79 pleural effusions in order to evaluate the utility and reliability in diagnosing tuberculous effusions. The effusions were grouped by the etiology: 26 were tuberculous (group I); 22 were neoplastic (group II); 11 were pneumonic (group III); 10 were non-infections exudates of different causes (group IV); and 10 transudates (group V). Group I presented the higher median value of AD (MED = 81.92; DE: 29.02) the difference being statistically significant (p less than 0.0001) compared with the results of the other groups. We found 2 cases of pleural tuberculosis histologically demonstrated with AD levels under the amount of 40 U/L. In our experience, AD determination had a sensitivity of 92% and specificity of 94%; with a predictive value of 89% and a negative predictive value of 96%, this being considered useful but non specific of tuberculosis.
- Published
- 1989
42. [Familial porphyria variegata. Clinical, biochemical and enzymatic study].
- Author
-
Fernández Herrera J, Perpiña J, Enríquez de Salamanca R, Aragües M, Pérez de Oteyza C, and García-Déz A
- Subjects
- Adult, Female, Humans, Pedigree, Porphyrias metabolism, Porphyrins metabolism, Skin Diseases metabolism, Porphyrias genetics, Skin Diseases genetics
- Published
- 1986
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