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Your search keyword '"Pérez del Palomar, Amaya"' showing total 39 results
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39 results on '"Pérez del Palomar, Amaya"'

2. Immune Analysis Using Vitreous Optical Coherence Tomography Imaging in Rats with Steroid-Induced Glaucoma

Author

Rodrigo, Maria J., primary, Subías, Manuel, additional, Montolío, Alberto, additional, Martínez-Rincón, Teresa, additional, Aragón-Navas, Alba, additional, Bravo-Osuna, Irene, additional, Pablo, Luis E., additional, Cegoñino, Jose, additional, Herrero-Vanrell, Rocío, additional, Garcia-Martin, Elena, additional, and Pérez del Palomar, Amaya, additional

Published
2024
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8. The macular retinal ganglion cell layer as a biomarker for diagnosis and prognosis in multiple sclerosis: A deep learning approach.

Author

Montolío, Alberto, Cegoñino, José, Garcia‐Martin, Elena, and Pérez del Palomar, Amaya

Subjects
RETINAL ganglion cells, ARTIFICIAL neural networks, DEEP learning, MULTIPLE sclerosis, OPTICAL coherence tomography, RETINAL blood vessels, MACULA lutea
Abstract

Purpose: The macular ganglion cell layer (mGCL) is a strong potential biomarker of axonal degeneration in multiple sclerosis (MS). For this reason, this study aims to develop a computer‐aided method to facilitate diagnosis and prognosis in MS. Methods: This paper combines a cross‐sectional study of 72 MS patients and 30 healthy control subjects for diagnosis and a 10‐year longitudinal study of the same MS patients for the prediction of disability progression, during which the mGCL was measured using optical coherence tomography (OCT). Deep neural networks were used as an automatic classifier. Results: For MS diagnosis, greatest accuracy (90.3%) was achieved using 17 features as inputs. The neural network architecture comprised the input layer, two hidden layers and the output layer with softmax activation. For the prediction of disability progression 8 years later, accuracy of 81.9% was achieved with a neural network comprising two hidden layers and 400 epochs. Conclusion: We present evidence that by applying deep learning techniques to clinical and mGCL thickness data it is possible to identify MS and predict the course of the disease. This approach potentially constitutes a non‐invasive, low‐cost, easy‐to‐implement and effective method. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Surgical Planning and Patient-Specific Biomechanical Simulation for Tracheal Endoprostheses Interventions

Author

González Ballester, Miguel A., Pérez del Palomar, Amaya, López Villalobos, José Luís, Lara Rodríguez, Laura, Trabelsi, Olfa, Pérez, Frederic, Ginel Cañamaque, Ángel, Barrot Cortés, Emilia, Rodríguez Panadero, Francisco, Doblaré Castellano, Manuel, Herrero Jover, Javier, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Yang, Guang-Zhong, editor, Hawkes, David, editor, Rueckert, Daniel, editor, Noble, Alison, editor, and Taylor, Chris, editor

Published
2009
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14. Analysis of Parainflammation in Chronic Glaucoma Using Vitreous-OCT Imaging

Author

Rodrigo, María Jesús, primary, Subías, Manuel, additional, Montolío, Alberto, additional, Méndez-Martínez, Silvia, additional, Martínez-Rincón, Teresa, additional, Arias, Lorena, additional, García-Herranz, David, additional, Bravo-Osuna, Irene, additional, Garcia-Feijoo, Julian, additional, Pablo, Luis, additional, Cegoñino, José, additional, Herrero-Vanrell, Rocio, additional, Carretero, Ana, additional, Ruberte, Jesus, additional, Garcia-Martin, Elena, additional, and Pérez del Palomar, Amaya, additional

Published
2021
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15. Monitoring new long-lasting intravitreal formulation for glaucoma with vitreous images using optical coherence tomography

Author

Instituto de Salud Carlos III, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), European Commission, Rodrigo, María J., Pérez del Palomar, Amaya, Montolío, Alberto, Méndez-Martínez, Silvia, Subias, Manuel, Cardiel, María José, Martínez-Rincón, Teresa, Cegoñino, José, Fraile, José M., Vispe, Eugenio, Mayoral, José A., Polo, Vicente, García-Martín, Elena, Instituto de Salud Carlos III, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), European Commission, Rodrigo, María J., Pérez del Palomar, Amaya, Montolío, Alberto, Méndez-Martínez, Silvia, Subias, Manuel, Cardiel, María José, Martínez-Rincón, Teresa, Cegoñino, José, Fraile, José M., Vispe, Eugenio, Mayoral, José A., Polo, Vicente, and García-Martín, Elena

Abstract

Intravitreal injection is the gold standard therapeutic option for posterior segment pathologies, and long-lasting release is necessary to avoid reinjections. There is no effective intravitreal treatment for glaucoma or other optic neuropathies in daily practice, nor is there a non-invasive method to monitor drug levels in the vitreous. Here we show that a glaucoma treatment combining a hypotensive and neuroprotective intravitreal formulation (IF) of brimonidine–Laponite (BRI/LAP) can be monitored non-invasively using vitreoretinal interface imaging captured with optical coherence tomography (OCT) over 24 weeks of follow-up. Qualitative and quantitative characterisation was achieved by analysing the changes in vitreous (VIT) signal intensity, expressed as a ratio of retinal pigment epithelium (RPE) intensity. Vitreous hyperreflective aggregates mixed in the vitreous and tended to settle on the retinal surface. Relative intensity and aggregate size progressively decreased over 24 weeks in treated rat eyes as the BRI/LAP IF degraded. VIT/RPE relative intensity and total aggregate area correlated with brimonidine levels measured in the eye. The OCT-derived VIT/RPE relative intensity may be a useful and objective marker for non-invasive monitoring of BRI/LAP IF.

Published
2021

18. Surgical Planning and Patient-Specific Biomechanical Simulation for Tracheal Endoprostheses Interventions

Author

González Ballester, Miguel A., primary, Pérez del Palomar, Amaya, additional, López Villalobos, José Luís, additional, Lara Rodríguez, Laura, additional, Trabelsi, Olfa, additional, Pérez, Frederic, additional, Ginel Cañamaque, Ángel, additional, Barrot Cortés, Emilia, additional, Rodríguez Panadero, Francisco, additional, Doblaré Castellano, Manuel, additional, and Herrero Jover, Javier, additional

Published
2009
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22. Evaluation with angiography by optical coherence tomography of patients with multiple sclerosis

Author

Cordón Ciordia, Beatriz, primary, Pérez Velilla, Javier, additional, José Vicente Altabas, Maria, additional, Viladés Palomar, Elisa, additional, Orduna Hospital, Elvira, additional, Pérez ‐ Del Palomar, Amaya, additional, Cegoñino Banzo, Jose, additional, Montolio Marco, Alberto, additional, Ramón Ara Callizo, Jose, additional, Jesus Rodrigo Sanjuán, Maria, additional, Satué Palacián, Maria, additional, and García‐Martín, Elena, additional

Published
2019
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25. Numerical models for mammoplasty simulations

Author

Lapuebla-Ferri, Andrés, Pérez del Palomar, Amaya, Cegoñino, José, and Jiménez-Mocholí, Antonio José

Subjects
Finite Element Method, skin and connective tissue diseases, Breast mammoplasty, Computer simulations, Numerical model
Abstract

Female breast is a fundamental organ to sustain the newborn during lactation, and it is relevant for the social and affective relationships of the woman. A mammoplasty is a surgical intervention that is aimed to correct some type of deformity or improve the appearance of the breast. In particular, an augmentation mammoplasty consists of increasing the volume of the breast by inserting prosthesis, mostly for aesthetic purposes. At present, no method exists to predict the final appearance of the breast following an augmentation mammoplasty. In fact, the results depend on the clinician skills. The present work summarizes the main contributions of the Finite Element (FE) simulations to surgical planning and prognosis of breast mammoplasties during the last decade. An original contribution of the authors to simulate an augmentation mammoplasty is also described.

Published
2019

26. Validation of non-invasive treatments for temporomandibular joint disorders during childhood considering the porous-fibrous properties of the joint

Author

Ortún-Terrazas, Javier, Cegoñino, José, Santana-Penín, Urbano, Santana-Mora, Urbano, and Pérez del Palomar, Amaya

Subjects
stomatognathic diseases, stomatognathic system
Abstract

Many of the temporomandibular joint (TMJ) disorders occur during growth. An early treatment would improve the life of the patients and avoid later surgical treatment [1]. Nowadays, TMJ treatments are exclusively performed from a clinical point of view. Finite elements (FE) models are not used due to the complex geometry of the TMJ and because the properties of the soft tissues are unknown [2]. Thus, the purpose of this study is multiple: 1. To diagnose the TMJ disorder in a child patient using FE analysis. 2. To characterize the behaviour of the tissues of the TMJ using porous-fibrous material models. 3. To numerically design a non-invasive treatment. 4. To clinically perform the designed treatment.

Published
2018
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32. Finite element model of the nonlinear behaviour of the human periodontal ligament

Author

Ortún-Terrazas, Javier, Cegoñino, José, Santana-Penín, Urbano, Santana-Mora, Urbano, and Pérez del Palomar, Amaya

Subjects
stomatognathic system
Abstract

It is well known that the periodontal ligament (PDL) plays a key role in transferring loads from the teeth to the alveolar bone, and it is becoming increasingly difficult to ignore that PDL performs greatly in tooth movements [1]. Some authors stress that the use of 3D geometry is mandatory; and plane models should never be used to simulate the tooth/bone system under load [2]. Although, more recent studies [3] proposed porohyperelastic models, the material properties of PDL are still not clarified [2][3]. The aim of this study is to validate and evaluate a finite element (FE) model based on the real geometry of a specimen extracted from a fresh human cadaver obtained by computer micro-tomography (µCT). For that purpose, the PDL behaviour was defined as a porous hyperelastic anisotropic material.

Published
2017
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36. Calculo de volúmenes en modelos remallados de elementos finitos

Author

Lapuebla-Ferri, Andrés, Giménez, Fernando, Jiménez, A.J., Monsoriu, Juan A., Pérez del Palomar, Amaya, Lapuebla-Ferri, Andrés, Giménez, Fernando, Jiménez, A.J., Monsoriu, Juan A., and Pérez del Palomar, Amaya

Abstract

[EN] Computer-assisted Finite Element Method is a widespread tool in the field of engineering. In certain applications, it is necessary to modify the mesh of the model during the analysis, which is known as ’remeshing’. In these situations, it is usually needed to perform some measurements, p.e., to calculate the volume of a region. Commercial packages can cover these needed, but they reveal to be limited in some situations. In this work, an application developed in MatlabQc is presented to approximately calculate the volume of a spatial region comprised between to meshes. The first is a quadrilateral finite element mesh, and the second mesh is topologically equivalent to the first and obtained through a remeshing process., [ES] El Método de los Elementos Finitos asistido por ordenador es una herramienta muy extendida en ingeniería. En ciertas aplicaciones, se precisa modificar la malla del modelo a lo largo del proceso de simulación, lo que se conoce como remallado. En estos casos, además, suele ser necesario realizar mediciones en el modelo de elementos finitos, como por ejemplo calcular el volumen de ciertas regiones del mismo. Los paquetes comerciales disponibles en la actualidad permiten satisfacer algunas de estas necesidades, aunque adolecen de ciertas limitaciones. En este trabajo se presenta una aplicación desarrollada en el código propio de MatlabQc, que permite el cálculo aproximado del volumen de una región del espacio comprendida entre una malla de elementos finitos cuadriláteros lineales y otra malla topológicamente equivalente a la anterior, esta última obtenida a través de un proceso de remallado.

Published
2011

39. A finite element comparison between the mechanical behaviour of rigid and resilient oral implants with respect to immediate loading.

Author

Pérez del Palomar A, Arruga A, Cegoñino J, and Doblaré M

Subjects
Computer Simulation, Dental Prosthesis Design methods, Elasticity, Equipment Failure Analysis methods, Finite Element Analysis, Humans, Stress, Mechanical, Dental Implants, Dental Stress Analysis methods, Mandible physiopathology, Mandible surgery, Models, Biological, Weight-Bearing
Abstract

In this paper, a qualitative comparison between two types of dental implants with respect to their behaviour under immediate loading is presented. This analysis has been carried out using the finite element method. Since micromotions (and not the load) are responsible of the appearance of a fibrous interface avoiding osseointegration, the relative displacement between the bone surface and the implant has been the main variable analyzed at different loading states and for the two implant types here considered. The implants analyzed differ in their mechanical behavior: rigid or resilient. Their main difference lies in the joining between the different pieces that make up the dental system. While in the rigid implant all the pieces are screwed, in the resilient implant a relative displacement between the pieces is allowed, with the additional introduction of a silicone gasket that acts like the periodontal ligament. Both implants were considered with a similar geometry and under two different loading scenarios, one equivalent to the force of chewing applied to a molar and another which corresponds to a premolar. For the resilient implant, a hyperelastic behaviour for the silicone and contact conditions between the different mobile parts of the implant are considered. The displacements of the emerging-body in both designs are also compared with the values obtained by several authors. However, the results show that both implants fulfill the constraint of the immediate loading protocol. The micromotions of the resilient implant are lower to those of the rigid one, favouring therefore a good osseointegration process while keeping the stresses in the implant under admissible maximum values.

Published
2005
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