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This study explored the enantiocomplementary bioreduction of substituted 1-(arylsulfanyl)propan-2-ones in batch mode using four wild-type yeast strains and two different recombinant alcohol dehydrogenases from Lactobacillus kefir and Rhodococcus aetherivorans. The selected yeast strains and recombinant alcohol dehydrogenases as whole-cell biocatalysts resulted in the corresponding 1-(arylsulfanyl)propan-2-ols with moderate to excellent conversions (60–99%) and high selectivities (ee > 95%). The best bioreductions—in terms of conversion (>90%) and enantiomeric excess (>99% ee)—at preparative scale resulted in the expected chiral alcohols with similar conversion and selectivity to the screening reactions.

IntroductionRadiological assessment is necessary to diagnose spontaneous intracerebral hemorrhage (ICH) and traumatic brain injury intracranial hemorrhage (TBI-bleed). Artificial intelligence (AI) deep learning tools provide a means for decision support. This study evaluates the hemorrhage segmentations produced from three-dimensional deep learning AI model that was developed using non-contrast computed tomography (CT) imaging data external to the current study.MethodsNon-contrast CT imaging data from 1263 patients were accessed across seven data sources (referred to as sites) in Norway and Sweden. Patients were included based on ICH, TBI-bleed, or mild TBI diagnosis. Initial non-contrast CT images were available for all participants. Hemorrhage location frequency maps were generated. The number of estimated haematoma clusters was correlated with the total haematoma volume. Ground truth expert annotations were available for one ICH site; hence, a comparison was made with the estimated haematoma volumes. Segmentation volume estimates were used in a receiver operator characteristics (ROC) analysis for all samples (i.e., bleed detected) and then specifically for one site with few TBI-bleed cases.ResultsThe hemorrhage frequency maps showed spatial patterns of estimated lesions consistent with ICH or TBI-bleed presentations. There was a positive correlation between the estimated number of clusters and total haematoma volume for each site (correlation range: 0.45–0.74; each p-value < 0.01) and evidence of ICH between-site differences. Relative to hand-drawn annotations for one ICH site, the VIOLA-AI segmentation mask achieved a median Dice Similarity Coefficient of 0.82 (interquartile range: 0.78 and 0.83), resulting in a small overestimate in the haematoma volume by a median of 0.47 mL (interquartile range: 0.04 and 1.75 mL). The bleed detection ROC analysis for the whole sample gave a high area-under-the-curve (AUC) of 0.92 (with sensitivity and specificity of 83.28% and 95.41%); however, when considering only the mild head injury site, the TBI-bleed detection gave an AUC of 0.70.DiscussionAn open-source segmentation tool was used to visualize hemorrhage locations across multiple data sources and revealed quantitative hemorrhage site differences. The automated total hemorrhage volume estimate correlated with a per-participant hemorrhage cluster count. ROC results were moderate-to-high. The VIOLA-AI tool had promising results and might be useful for various types of intracranial hemorrhage.

Abstract Randomized controlled trials (RCTs) have been considered as gold standard for establishing the efficacy and safety of investigational new drugs; nonetheless, the generalizability of their findings has been questioned. To address this issue, an increasing number of naturalistic studies and real-world database analyses have been conducted. The question of how much information from these two approaches is congruent or discrepant with each other is of great importance for the clinical practice. To answer this question, we focused on data from the antipsychotic (AP) treatment of schizophrenia. Our aim was two-fold: to conduct a meta-analysis of real-world studies (RWS), and to compare the results of RWS meta-analysis with previously published meta-analyses of RCTs. The principal measure of effectiveness was all-cause treatment discontinuation for both RWS and RCTs (when not available, then drop out for RCTs). We included publications for 8 selected APs (oral formulations of amisulpride, aripiprazole, clozapine, haloperidol, olanzapine, quetiapine, risperidone, and long-acting injectable (LAI) risperidone). We identified 11 RWS and 7 RCT meta-analyses for inclusion. Our results indicated that the RWS yielded statistically conclusive and consistent findings across individual investigations. For the overwhelming majority of the comparisons where both RWS and RCT meta-analyses were available, there was good congruency between the RWS and the RCT results. Our results support that RCTs, despite their limitations, provide evidence which is generalizable to real-world settings. This is an important finding for both regulators and clinicians. RWS can provide guidance for situations where no evidence is available from double-blind clinical trials.

IntroductionMinimum clinically important difference (MCID) is a measure that defines the minimum amount of change in an objective score of a clinical test that must be reached for that change to be clinically noticeable. We aimed to find the MCID for patients with predominantly negative symptoms of schizophrenia at its earliest occurrence.MethodsData of a 26-week long, double-blind study with 454 patients [Positive and Negative Symptom Scale Negative Factor Score (PANSS-FSNS) ≥24, Positive and Negative Symptom Scale Positive Factor Score (PANSS-FSPS) ≤ 19] treated with cariprazine 4.5 mg/d or risperidone 4 mg/d were analyzed. The Clinical Global Impression—Improvement scale was used to quantify minimum improvement (CGI-I = 3) and no clinical change (CGI-I = 4) on the PANSS-FSNS, and the MCID was estimated with the following methods: as the mean PANSS-FSNS changes corresponding to the first instance of minimal improvement across all visits (MCID1); as the difference between the PANSS-FSNS change associated with the first instance and the PANSS-FSNS changes associated with the last recorded clinically unchanged status across all visits (MCID2); with the effect size approach (MCID3); as the Youden Index based cut-off value between no clinical change and minimal improvement (MCID4); as the relative likelihood of minimal improvement (MCID5).ResultsThe MCID1 and MCID2 resulted in, respectively, a 3.8-point (18.5%) and a 1.5-point (7.3%) decrease from baseline severity on the PANSS-FSNS. Greater values were required for the MCID at later evaluation times. The cut-off between minimum improvement and no clinical change defined by the Youden Index was a−3-point (15%) change in the PANSS-FSNS. The effect size approach indicated the 1.5-point difference between minimally improved and unchanged patients to be a medium effect (ES = 0.6).ConclusionApplying different methods led to different results, ranging between 7.3 and 18.5% improvement from the baseline for the MCID at its earliest occurrence in patients with predominantly negative symptoms of schizophrenia.

Abstract Background Children with attention-deficit/hyperactivity disorder (ADHD) often demonstrate sensory processing difficulties in the form of altered sensory modulation, which may contribute to their symptomatology. Our objective was to investigate the neurophysiological correlates of sensory processing deficits and the electrophysiological characteristics of early information processing in adult ADHD, measured by the P1 event-related potential (ERP). Methods We obtained ERPs during a Go/NoGo task from 26 adult patients with ADHD and 25 matched controls using a high-density 128-channel BioSemi ActiveTwo recording system. Results ADHD patients had a significantly reduced P1 component at occipital and inferotemporal scalp areas compared to controls. The reduction was associated with inattention and hyperactivity symptom severity, as measured by the Conners’ Adult ADHD Rating Scale. ADHD patients with higher inattention scores had significantly smaller P1 amplitudes at posterior scalp sites, while higher hyperactivity scores were associated with higher P1 amplitudes. Conclusions Deficits in early sensory processing, as measured by the P1 ERP component, are present in adult ADHD patients and are associated with symptom severity. These findings are suggestive of bottom-up cognitive deficits in ADHD driven by impairments in early visual processing, and provide evidence that sensory processing problems are present at the neurophysiological level in this population.

Az endogén növekedéselmélet, vagy - ahogyan sokszor nevezik - az új növekedéselmélet mintegy húsz év alatt kiforrott elméletté vált. Az elmélet eredeti célja az volt, hogy jobb magyarázatot adjon a tényekre, mint a hagyományos teóriák, ez azonban csak részben sikerült. Ha ez így van, akkor mi a hozadéka az egész elméletnek? E tanulmány azt kívánja bizonyítani, hogy bár a tények nem sokkal jobb magyarázatát nyújtja az endogén elmélet, de elmélyítette a gazdasági növekedés megértését, és olyan tényezőket emelt be a formális elméletbe, amelyekkel eddig csak a növekedéselmélet "puhább" ágai foglalkoztak.

A növekedéselméletnek tulajdonképpen egy alapkérdése van: miért szegények egyes országok, mások pedig miért gazdagok. A szerző a növekedéselméleten belül alapvetően két irányzatot azonosít Williamson társadalmi elemzési struktúrája segítségével és rámutat arra, hogy mindkét alapvető megközelítés egyoldalú választ ad erre a kérdésre. A tanulmány azt a vállalatelméletből ismert kritikát alkalmazza a két irányzatra, mely szerint az egyik irányzat túl nagy hangsúlyt fektet a technológiára, a másik pedig a tranzakciós költségekre és az ösztönzőkre. Kibontakozóban van azonban egy olyan új megközelítés, amely képes integrálni e két oldalt. E megközelítés a modern osztrák közgazdaságtan elméleti meglátásaiból indul ki.

A recenzió két nemrég megjelent kötetet, Erwin Dekker osztrák közgazdaságtan kulturális gyökereiről szóló (Erwin Dekker, The Viennese Students of Civilization: The Meaning and Context of Austrian Economics Reconsidered, Cambridge University Press, New York, 2016, xii+220 oldal) és a Levy – Peart szerzőpáros a szakértők gazdaságpolitikai szerepéről szóló (David M. Levy és Sandra J. Peart, Escape from Democracy: The Role of Experts and the Public in Economic Policy. Cambridge University Press, New York, 2017, Kindle Edition) munkáját tekinti át. A két kötet kiegészíti egymást, mert mindkettő a közgazdaságtan és a gazdaságpolitika kapcsolatának hagyományos felfogását vonja kétségbe és alternatív – szerényebb – közgazdász szerepfelfogást javasol.

Tisztelgés az egyensúlyteremtő előtt A magyar közgazdaságtan él és virul A kifinomult józan ész története Brzeziński stratégiai víziója

The article below reviews two works, that of Rose [2019] and of McCleary and Barro [2019], published recently which focus on the same broad topic although from a different point of view: the relationship between culture and economic growth. The two works complement each other. Whereas Rose [2019] provides genuine economic arguments for his case about the importance of trust and trustworthiness, McCleary and Barro [2019] ask much more specific questions such as which religious beliefs contribute to economic growth and why a certain church behaved in a certain way in different – historical and modern – periods, and support their case with some econometrics.

To improve the accuracy of Injury Severity Prediction in the event of vehicle crash, a new algorithm is proposed using the US vehicle accident database (NASS-CDS). This proposed algorithm work over the base algorithm (introduced by kononen et al) in which, some of the additional variables were introduced and some of the existing variable’s classifications were modified. Results suggest that the proposed algorithm has some advantage over the base algorithm.

The “efficient institutions view” on property rights claims that property rights emerged and are enforced when their enforcement maximizes net wealth. In a cross-country pattern this is usually understood as the prediction that economic development creates the incentives to provide higher quality property rights, but this claim is highly debated. This paper tries to take various property rights scholars’ arguments seriously and see property rights quality as a two dimensional concept, the two dimensions being the definition and the assignment of property rights. The paper derives a measure for these two dimensions of property rights and shows that it is the assignment dimension which is determined by development, while the definition dimensions is rather determined by cultural factors, especially those deeper factors that seem to reflect a long-run effect of Western European culture. According to the paper, the main reasons behind this may be the difference in the expropriability of income generated by an improvement of each dimension, and the way such improvements may or may not affect countries’ catching up process.

A tanulmány a kultúra, a gazdasági növekedés és az intézmények viszonyát vizsgáló irodalomból vezet le hipotéziseket a piaci eszmék (beliefs), a piaci intézmények és a termelékenység viszonyára vonatkozóan, és országkeresztmetszeti adatokon teszteli azokat. Rámutat egyrészt, hogy a három tényező ok-okozati kapcsolatára felírható négy hipotézis mindegyikének van közgazdasági irodalma, amennyiben a piaci eszméket a kultúra részének tekintjük. Másrészt, azt kihasználva teszteli a hipotéziseket országkeresztmetszeti adatokon, hogy azok különböző változókat tekintenek exogénnek. A piaci eszmék mércéi a World Values Survey egyéni adatain futtatott regressziókban szereplő ország-dummyk koefficiensei. A teszt azon két hipotézisnek ad igazat, miszerint az intézmények exogének, nem a piaci eszmék. Journal of Economic Literature (JEL) kódok: L26, O43, P16

Several structural brain abnormalities have been associated with aggression in patients with schizophrenia. However, little is known about shared and distinct abnormalities underlying aggression in these subjects and non-psychotic violent individuals. We applied a region-of-interest volumetric analysis of the amygdala, hippocampus, and thalamus bilaterally, as well as whole brain and ventricular volumes to investigate violent (n = 37) and non-violent chronic patients (n = 26) with schizophrenia, non-psychotic violent (n = 24) as well as healthy control subjects (n = 24). Shared and distinct volumetric abnormalities were probed by analysis of variance with the factors violence (non-violent versus violent) and diagnosis (non-psychotic versus psychotic), adjusted for substance abuse, age, academic achievement and negative psychotic symptoms. Patients showed elevated vCSF volume, smaller left hippocampus and smaller left thalamus volumes. This was particularly the case for non-violent individuals diagnosed with schizophrenia. Furthermore, patients had reduction in right thalamus size. With regard to left amygdala, we found an interaction between violence and diagnosis. More specifically, we report a double dissociation with smaller amygdala size linked to violence in non-psychotic individuals, while for psychotic patients smaller size was linked to non-violence. Importantly, the double dissociation appeared to be mostly driven by substance abuse. Overall, we found widespread morphometric abnormalities in subcortical regions in schizophrenia. No evidence for shared volumetric abnormalities in individuals with a history of violence was found. Finally, left amygdala abnormalities in non-psychotic violent individuals were largely accounted for by substance abuse. This might be an indication that the association between amygdala reduction and violence is mediated by substance abuse. Our results indicate the importance of structural abnormalities in aggressive individuals.

Ösztönzi-e a gazdasági fejlődés a demokrácia kialakulását, ahogyan azt a Lipset-hipotézisként elhíresült állítás mondja? A tanulmány szerint a Lipset-hipotézis érvényesüléséhez elegendő, ha egy ideológiai és egy technológiai feltétel teljesül. Az ideológiai az, hogy a politikai programalkotó ideológia a klasszikus liberalizmus legyen, amelynek az a sajátossága, hogy a demokráciával szembeni ellenszenvet kombinálja a gazdasági és a polgári szabadság pozitív megítélésével. A technológiai feltétel pedig az, hogy az adott ország technológiai vezető pozícióban legyen, mert ekkor a gondolatok szabad piaca által ösztönzött innováció nélkül nincs gazdasági növekedés. A paneladatokon végzett logit regressziók azt mutatják, hogy a 20. század elejét megelőző időszakban a nagyobb jövedelem növeli a demokratikus irányú átmenet valószínűségét, de utána már nem. A magyarázat az, hogy a Nyugat országaiban a 20. század elejéig fennállt a két feltétel, de a 20. század eleje után potenciálisan demokratizálódó országokra már nem. Journal of Economic Literature (JEL) codes: D70, O11, O43

El objetivo de este trabajo fue evaluar el efecto de la inseminación artificial postcervical sobre el tamaño de la camada y la tasa de fertilización y comparar los costos de inseminación por dosis. Se usaron ochenta hembras destetas en una granja comercial ubicada en el municipio de Ricaurte (Cundinamarca). El semen fue colectado de machos de la granja y se prepararon para inseminar dosis de 3x109 spz en 100 ml de volumen. Las dosis se almacenaron entre 14 y 16°C por tres días máximo. La detección de celos se realizó dos veces al día (entre las 6:30 y las 18:30) con machos adultos y maduros. Las técnicas de inseminación utilizadas fueron la cervical, en la que se usaron catéteres tradicionales Mini-TübTM, o transcervical, en la que se usaron catéteres para inseminación postcervical Absolute SowTM. En ambos tratamientos las cerdas fueron inseminadas tres veces, con intervalos de doce horas. La primera inseminación se hizo doce horas después de la detección del celo (determinada como reflejo de permanencia). El número de lechones nacidos vivos, nacidos totales, nacidos muertos y momias fue analizado por ANAVA, con el procedimiento GLM de SAS. Los factores que se tomaron en cuenta fueron el método de inseminación artificial, la semana en que se inseminó, el número de parto de la cerda y las interacciones entre el macho y el método de inseminación. No hubo diferencias significativas entre los métodos de inseminación artificial en relación con nacidos vivos, nacidos totales, nacidos muertos y momias. Lo mismo ocurrió con las interacciones ingresadas. Las hembras inseminadas con cualquiera de los métodos tuvieron tamaños de camada similares. No hubo diferencias significativas entre los tamaños de camada de hembras de segundo parto comparadas con hembras de séptimo parto, independientemente del método de inseminación.

Acquired deficits following glioma resection may not only occur due to accidental resection of normal brain tissue. The possible importance of ischemic injuries in causing neurological deficits after brain tumor surgery is not much studied. We aimed to study the volume and frequency of early postoperative circulatory changes (i.e. infarctions) detected by diffusion weighted resonance imaging (DWI) in patients with surgically acquired neurological deficits compared to controls.We designed a 1 ∶ 1 matched case-control study in patients with diffuse gliomas (WHO grade II-IV) operated with 3D ultrasound guided resection. 42 consecutive patients with acquired postoperative dysphasia and/or new motor deficits were compared to 42 matched controls without acquired deficits. Controls were matched with respect to histopathology, preoperative tumor volumes, and eloquence of location. Two independent radiologists blinded for clinical status assessed the postoperative DWI findings.Postoperative peri-tumoral infarctions were more often seen in patients with acquired deficits (63% versus 41%, p = 0.046) and volumes of DWI abnormalities were larger in cases than in controls with median 1.08 cm3 (IQR 0-2.39) versus median 0 cm3 (IQR 0-1.67), p = 0.047. Inter-rater agreement was substantial (67/82, κ = 0.64, p

Gender identity disorder (GID) refers to transsexual individuals who feel that their assigned biological gender is incongruent with their gender identity and this cannot be explained by any physical intersex condition. There is growing scientific interest in the last decades in studying the neuroanatomy and brain functions of transsexual individuals to better understand both the neuroanatomical features of transsexualism and the background of gender identity. So far, results are inconclusive but in general, transsexualism has been associated with a distinct neuroanatomical pattern. Studies mainly focused on male to female (MTF) transsexuals and there is scarcity of data acquired on female to male (FTM) transsexuals. Thus, our aim was to analyze structural MRI data with voxel based morphometry (VBM) obtained from both FTM and MTF transsexuals (n = 17) and compare them to the data of 18 age matched healthy control subjects (both males and females). We found differences in the regional grey matter (GM) structure of transsexual compared with control subjects, independent from their biological gender, in the cerebellum, the left angular gyrus and in the left inferior parietal lobule. Additionally, our findings showed that in several brain areas, regarding their GM volume, transsexual subjects did not differ significantly from controls sharing their gender identity but were different from those sharing their biological gender (areas in the left and right precentral gyri, the left postcentral gyrus, the left posterior cingulate, precuneus and calcarinus, the right cuneus, the right fusiform, lingual, middle and inferior occipital, and inferior temporal gyri). These results support the notion that structural brain differences exist between transsexual and healthy control subjects and that majority of these structural differences are dependent on the biological gender.

BACKGROUND AND OBJECTIVES:Mismatch negativity (MMN) is an event-related potential (ERP) measure of preattentional sensory processing. While deficits in the auditory MMN are robust electrophysiological findings in schizophrenia, little is known about visual mismatch response and its association with social cognitive functions such as emotion recognition in schizophrenia. Our aim was to study the potential deficit in the visual mismatch response to unexpected facial emotions in schizophrenia and its association with emotion recognition impairments, and to localize the sources of the mismatch signals. EXPERIMENTAL DESIGN:The sample comprised 24 patients with schizophrenia and 24 healthy control subjects. Controls were matched individually to patients by gender, age, and education. ERPs were recorded using a high-density 128-channel BioSemi amplifier. Mismatch responses to happy and fearful faces were determined in 2 time windows over six regions of interest (ROIs). Emotion recognition performance and its association with the mismatch response were also investigated. PRINCIPAL OBSERVATIONS:Mismatch signals to both emotional conditions were significantly attenuated in patients compared to controls in central and temporal ROIs. Controls recognized emotions significantly better than patients. The association between overall emotion recognition performance and mismatch response to the happy condition was significant in the 250-360 ms time window in the central ROI. The estimated sources of the mismatch responses for both emotional conditions were localized in frontal regions, where patients showed significantly lower activity. CONCLUSIONS:Impaired generation of mismatch signals indicate insufficient automatic processing of emotions in patients with schizophrenia, which correlates strongly with decreased emotion recognition.

We conducted a meta-analysis of studies examining the association between the Val158Met COMT polymorphism and violence against others in schizophrenia. A systematic search current to November 1, 2011 was conducted using MEDLINE, EMBASE, CINAHL, PsycINFO, ProQuest, and the National Criminal Justice Reference Service and identified 15 studies comprising 2,370 individuals with schizophrenia for inclusion. Bivariate analyses of study sensitivities and specificities were conducted. This methodology allowed for the calculation of pooled diagnostic odds ratios (DOR). Evidence of a significant association between the presence of a Met allele and violence was found such that men's violence risk increased by approximately 50% for those with at least one Met allele compared with homozygous Val individuals (DOR = 1.45; 95% CI = 1.05-2.00; z = 2.37, p = 0.02). No significant association between the presence of a Met allele and violence was found for women or when outcome was restricted to homicide. We conclude that male schizophrenia patients who carry the low activity Met allele in the COMT gene are at a modestly elevated risk of violence. This finding has potential implications for the pharmacogenetics of violent behavior in schizophrenia.

This paper, relying on a conceptualization of economic freedom in terms of kinds of government actions, develops a new measure of economic freedom. However, this is not art for art’s sake; instead, it allows us to provide an explanation for how particular institutions of economic freedom enhance economic development, a view upon which scholars agree. We develop two concepts related to economic freedom, namely the freedom-compatible and freedom-non-compatible institutions and use them as tools in an analysis of the process of economic growth, especially the relationship between economic freedom and long-run income. The major argument is that freedom-compatible institutions are primary determinants of income, while freedom-non-compatible institutions depend upon them and are partly the outcomes of the growth process itself, a fact which is explained by the Misesian theory of interventionism. Our regression analyses support our theoretical insights. JEL Classification: B53, H10, O10

A cikk a munkanélküliség idősorainak vizsgálatára vonatkozó irodalmat, illetve az e tesztek mögött meghúzódó közgazdasági magyarázatokat tekinti át. Választ keresünk arra, hogy mi az elméleti alapja a munkanélküliség idősoraiban az egységgyök létezését kutató teszteknek. Amellett érvelünk, hogy az e tesztek előtt álló egyik fő nehézséget a munkapiaci intézményrendszer megváltozása jelenti. A hagyományos egységgyöktesztek emiatt meglehetősen gyengévé válnak, míg a panel egységgyöktesztek a kérdés közgazdasági oldalát egyszerűsítik le. Következtetésünk, hogy az úgynevezett közel egységgyök-folyamatokra vonatkozó tesztek egyfajta kiutat jelenthetnek. Journal of Economic Literature (JEL) kód: C22, E24

Housing companies manage a considerable proportion of urban open green space in Sweden. This article explores how 62 Swedish housing companies, municipal and private, organise their open space maintenance and the reasons behind organisational structure. Here, organisational structure covers three aspects of open space maintenance: (1) whether performed in‐house or by a contractor, (2) whether performed by local managers or circulating teams, and (3) whether and how residents are involved in management. The organisational structures varied widely among the housing companies studied. Mixed structures were common. Formal resident involvement processes were almost only found in municipally owned areas with local managers. The arguments could be derived from two general management approaches, prioritizing either customer relations more or economic efficiency. The conclusion was that management approach might be important in choosing organisational structure. Santrauka Švedijos miestuose nemažą dalį atvirų žaliųjų plotų tvarko namų administravimo įmonės. Šiame straipsnyje nagrinėjama, kaip 62 (savivaldybių ir privačios) namų administravimo įmonės organizuoja atvirų plotų priežiūrą Švedijoje ir kokios priežastys lemia organizacinę struktūrą. Čia organizacinė struktūra apima tris atvirų plotų priežiūros aspektus: (1) plotus tvarko pačios ar samdo kitus, (2) tvarko vietiniai vadybininkai ar laikinos komandos, (3) ar prie tvarkymo prisideda ir kaip prisideda gyventojai. Nagrinėtose namų administravimo įmonėse rasta labai skirtingų organizacinių struktūrų. Mišrios struktūros populiariausios. Formalūs gyventojų įtraukimo procesai aptikti beveik išskirtinai tik savivaldybėms priklausančiose zonose su vietiniais tvarkytojais. Įrodymų buvo galima gauti iš dviejų pagrindinių vadybos požiūrių, prioritetą suteikiant ryšiams su klientais arba ekonominiam efektyvumui. Prieita prie išvados, kad vadybos požiūris gali būti svarbus renkantis organizacinę struktūrą. First published online: 18 Oct 2010