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5. SYNPA: SMT Performance Analysis and Allocation of Threads to Cores in ARM Processors

Author

Navarro, Marta, Feliu, Josué, Petit, Salvador, Gómez, María E., and Sahuquillo, Julio

Subjects
Computer Science - Distributed, Parallel, and Cluster Computing, Computer Science - Performance
Abstract

Simultaneous multithreading processors improve throughput over single-threaded processors thanks to sharing internal core resources among instructions from distinct threads. However, resource sharing introduces inter-thread interference within the core, which has a negative impact on individual application performance and can significantly increase the turnaround time of multi-program workloads. The severity of the interference effects depends on the competing co-runners sharing the core. Thus, it can be mitigated by applying a thread-to-core allocation policy that smartly selects applications to be run in the same core to minimize their interference. This paper presents SYNPA, a simple approach that dynamically allocates threads to cores in an SMT processor based on their run-time dynamic behavior. The approach uses a regression model to select synergistic pairs to mitigate intra-core interference. The main novelty of SYNPA is that it uses just three variables collected from the performance counters available in current ARM processors at the dispatch stage. Experimental results show that SYNPA outperforms the default Linux scheduler by around 36%, on average, in terms of turnaround time in 8-application workloads combining frontend bound and backend bound benchmarks., Comment: 11 pages, 9 figures

Published
2023

6. Development of Moral Judgments in Impersonal and Personal Dilemmas in Autistic Spectrum Disorders from Childhood to Late Adolescence

Author

Melanie Labusch, Manuel Perea, Rosa Sahuquillo-Leal, Isabel Bofill-Moscardó, Ángel Carrasco-Tornero, Antonio Cañada-Pérez, and Ana García-Blanco

Abstract

A potential underlying mechanism associated with the difficulties in social interactions in Autistic Spectrum Disorders (ASD) concerns the abnormal development of moral reasoning. The present study examined utilitarian and deontological judgments in impersonal and personal moral dilemmas, comparing 66 individuals with ASD and 61 typically developing (TD) individuals between 6 and 18 years. Utilitarian judgments decreased with age. This decline was much more gradual for personal dilemmas in the ASD than in the TD group. ASD individuals rated utilitarian judgments as more appropriate but felt less calm, consistent with the Empathy Imbalance hypothesis. Utilitarian judgments were associated with social interaction difficulties in ASD. These findings identify possible social therapeutic targets for more efficient coping strategies in individuals with ASD.

Published
2024
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7. Perceived Utility of Intracranial Pressure Monitoring in Traumatic Brain Injury: A Seattle International Brain Injury Consensus Conference Consensus-Based Analysis and Recommendations.

Author

Chesnut, Randall, Aguilera, Sergio, Buki, Andras, Bulger, Eileen, Citerio, Giuseppe, Cooper, D, Arrastia, Ramon, Diringer, Michael, Figaji, Anthony, Gao, Guoyi, Geocadin, Romergryko, Ghajar, Jamshid, Harris, Odette, Hawryluk, Gregory, Hoffer, Alan, Hutchinson, Peter, Joseph, Mathew, Kitagawa, Ryan, Manley, Geoffrey, Mayer, Stephan, Menon, David, Meyfroidt, Geert, Michael, Daniel, Oddo, Mauro, Okonkwo, David, Patel, Mayur, Robertson, Claudia, Rosenfeld, Jeffrey, Rubiano, Andres, Sahuquillo, Juain, Servadei, Franco, Shutter, Lori, Stein, Deborah, Stocchetti, Nino, Taccone, Fabio, Timmons, Shelly, Tsai, Eve, Ullman, Jamie, Videtta, Walter, Wright, David, and Zammit, Christopher

Subjects
Humans, Intracranial Pressure, Brain Injuries, Brain Injuries, Traumatic, Intracranial Hypertension, Glasgow Coma Scale, Monitoring, Physiologic
Abstract

BACKGROUND: Intracranial pressure (ICP) monitoring is widely practiced, but the indications are incompletely developed, and guidelines are poorly followed. OBJECTIVE: To study the monitoring practices of an established expert panel (the clinical working group from the Seattle International Brain Injury Consensus Conference effort) to examine the match between monitoring guidelines and their clinical decision-making and offer guidance for clinicians considering monitor insertion. METHODS: We polled the 42 Seattle International Brain Injury Consensus Conference panel members ICP monitoring decisions for virtual patients, using matrices of presenting signs (Glasgow Coma Scale [GCS] total or GCS motor, pupillary examination, and computed tomography diagnosis). Monitor insertion decisions were yes, no, or unsure (traffic light approach). We analyzed their responses for weighting of the presenting signs in decision-making using univariate regression. RESULTS: Heatmaps constructed from the choices of 41 panel members revealed wider ICP monitor use than predicted by guidelines. Clinical examination (GCS) was by far the most important characteristic and differed from guidelines in being nonlinear. The modified Marshall computed tomography classification was second and pupils third. We constructed a heatmap and listed the main clinical determinants representing 80% ICP monitor insertion consensus for our recommendations. CONCLUSION: Candidacy for ICP monitoring exceeds published indicators for monitor insertion, suggesting the clinical perception that the value of ICP data is greater than simply detecting and monitoring severe intracranial hypertension. Monitor insertion heatmaps are offered as potential guidance for ICP monitor insertion and to stimulate research into what actually drives monitor insertion in unconstrained, real-world conditions.

Published
2023

10. Integrating Dark Matter, Modified Gravity, and the Humanities

Author

Martens, Niels C. M., Sahuquillo, Miguel Ángel Carretero, Scholz, Erhard, Lehmkuhl, Dennis, and Krämer, Michael

Subjects
Physics - History and Philosophy of Physics, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies, General Relativity and Quantum Cosmology, High Energy Physics - Theory
Abstract

Editorial of a special issue on dark matter & modified gravity, distributed across the journals Studies in History and Philosophy of Modern Physics and Studies in History and Philosophy of Science. Published version of the open access editorial (in SHPS) available here: https://doi.org/10.1016/j.shpsa.2021.08.015. The six papers are collected here: https://www.sciencedirect.com/journal/studies-in-history-and-philosophy-of-science-part-b-studies-in-history-and-philosophy-of-modern-physics/special-issue/10CR71RJLWM., Comment: 14 pages, 0 figures, editorial of a special issue on dark matter & modified gravity

Published
2022
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12. Understanding Cloud Workloads Performance in a Production like Environment

Author

Pons, Lucia, Feliu, Josué, Puche, José, Huang, Chaoyi, Petit, Salvador, Pons, Julio, Gómez, María E., and Sahuquillo, Julio

Subjects
Computer Science - Distributed, Parallel, and Cluster Computing
Abstract

Understanding inter-VM interference is of paramount importance to provide a sound knowledge and understand where performance degradation comes from in the current public cloud. With this aim, this paper devises a workload taxonomy that classifies applications according to how the major system resources affect their performance (e.g., tail latency) as a function of the level of load (e.g., QPS). After that, we present three main studies addressing three major concerns to improve the cloud performance: impact of the level of load on performance, impact of hyper-threading on performance, and impact of limiting the major system resources (e.g., last level cache) on performance. In all these studies we identified important findings that we hope help cloud providers improve their system utilization., Comment: 16 pages, 17 figures. Submitted to Journal of Parallel and Distributed Computing

Published
2020

14. Correction: Early management of isolated severe traumatic brain injury patients in a hospital without neurosurgical capabilities: a consensus and clinical recommendations of the World Society of Emergency Surgery (WSES)

Author

Picetti, Edoardo, Catena, Fausto, Abu-Zidan, Fikri, Ansaloni, Luca, Armonda, Rocco A., Bala, Miklosh, Balogh, Zsolt J., Bertuccio, Alessandro, Biffl, Walt L., Bouzat, Pierre, Buki, Andras, Cerasti, Davide, Chesnut, Randall M., Citerio, Giuseppe, Coccolini, Federico, Coimbra, Raul, Coniglio, Carlo, Fainardi, Enrico, Gupta, Deepak, Gurney, Jennifer M., Hawryluk, Gregory W. J., Helbok, Raimund, Hutchinson, Peter J. A., Iaccarino, Corrado, Kolias, Angelos, Maier, Ronald W., Martin, Matthew J., Meyfroidt, Geert, Okonkwo, David O., Rasulo, Frank, Rizoli, Sandro, Rubiano, Andres, Sahuquillo, Juan, Sams, Valerie G., Servadei, Franco, Sharma, Deepak, Shutter, Lori, Stahel, Philip F., Taccone, Fabio S., Udy, Andrew, Zoerle, Tommaso, Agnoletti, Vanni, Bravi, Francesca, De Simone, Belinda, Kluger, Yoram, Martino, Costanza, Moore, Ernest E., Sartelli, Massimo, Weber, Dieter, and Robba, Chiara

Published
2023
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15. Early management of isolated severe traumatic brain injury patients in a hospital without neurosurgical capabilities: a consensus and clinical recommendations of the World Society of Emergency Surgery (WSES)

Author

Picetti, Edoardo, Catena, Fausto, Abu-Zidan, Fikri, Ansaloni, Luca, Armonda, Rocco A., Bala, Miklosh, Balogh, Zsolt J., Bertuccio, Alessandro, Biffl, Walt L., Bouzat, Pierre, Buki, Andras, Cerasti, Davide, Chesnut, Randall M., Citerio, Giuseppe, Coccolini, Federico, Coimbra, Raul, Coniglio, Carlo, Fainardi, Enrico, Gupta, Deepak, Gurney, Jennifer M., Hawryluk, Gregory W. J., Helbok, Raimund, Hutchinson, Peter J. A., Iaccarino, Corrado, Kolias, Angelos, Maier, Ronald W., Martin, Matthew J., Meyfroidt, Geert, Okonkwo, David O., Rasulo, Frank, Rizoli, Sandro, Rubiano, Andres, Sahuquillo, Juan, Sams, Valerie G., Servadei, Franco, Sharma, Deepak, Shutter, Lori, Stahel, Philip F., Taccone, Fabio S., Udy, Andrew, Zoerle, Tommaso, Agnoletti, Vanni, Bravi, Francesca, De Simone, Belinda, Kluger, Yoram, Martino, Costanza, Moore, Ernest E., Sartelli, Massimo, Weber, Dieter, and Robba, Chiara

Published
2023
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17. Sulfonylurea Receptor 1 in Central Nervous System Injury: An Updated Review

Author

Jha, Ruchira M, Rani, Anupama, Desai, Shashvat M, Raikwar, Sudhanshu, Mihaljevic, Sandra, Munoz-Casabella, Amanda, Kochanek, Patrick M, Catapano, Joshua, Winkler, Ethan, Citerio, Giuseppe, Hemphill, J Claude, Kimberly, W Taylor, Narayan, Raj, Sahuquillo, Juan, Sheth, Kevin N, and Simard, J Marc

Subjects
Autoimmune Disease, Brain Disorders, Traumatic Head and Spine Injury, Stroke, Physical Injury - Accidents and Adverse Effects, Neurodegenerative, Neurosciences, Neurological, Animals, Brain Injuries, Central Nervous System Diseases, Humans, Sulfonylurea Receptors, sulfonylurea receptor, edema, cellular swelling, traumatic brain injury, stroke, SUR 1, TRPM4, clinical trials, Other Chemical Sciences, Genetics, Other Biological Sciences, Chemical Physics
Abstract

Sulfonylurea receptor 1 (SUR1) is a member of the adenosine triphosphate (ATP)-binding cassette (ABC) protein superfamily, encoded by Abcc8, and is recognized as a key mediator of central nervous system (CNS) cellular swelling via the transient receptor potential melastatin 4 (TRPM4) channel. Discovered approximately 20 years ago, this channel is normally absent in the CNS but is transcriptionally upregulated after CNS injury. A comprehensive review on the pathophysiology and role of SUR1 in the CNS was published in 2012. Since then, the breadth and depth of understanding of the involvement of this channel in secondary injury has undergone exponential growth: SUR1-TRPM4 inhibition has been shown to decrease cerebral edema and hemorrhage progression in multiple preclinical models as well as in early clinical studies across a range of CNS diseases including ischemic stroke, traumatic brain injury, cardiac arrest, subarachnoid hemorrhage, spinal cord injury, intracerebral hemorrhage, multiple sclerosis, encephalitis, neuromalignancies, pain, liver failure, status epilepticus, retinopathies and HIV-associated neurocognitive disorder. Given these substantial developments, combined with the timeliness of ongoing clinical trials of SUR1 inhibition, now, another decade later, we review advances pertaining to SUR1-TRPM4 pathobiology in this spectrum of CNS disease-providing an overview of the journey from patch-clamp experiments to phase III trials.

Published
2021

18. A management algorithm for adult patients with both brain oxygen and intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC).

Author

Chesnut, Randall, Aguilera, Sergio, Buki, Andras, Bulger, Eileen, Citerio, Giuseppe, Cooper, D Jamie, Arrastia, Ramon Diaz, Diringer, Michael, Figaji, Anthony, Gao, Guoyi, Geocadin, Romer, Ghajar, Jamshid, Harris, Odette, Hoffer, Alan, Hutchinson, Peter, Joseph, Mathew, Kitagawa, Ryan, Manley, Geoffrey, Mayer, Stephan, Menon, David K, Meyfroidt, Geert, Michael, Daniel B, Oddo, Mauro, Okonkwo, David, Patel, Mayur, Robertson, Claudia, Rosenfeld, Jeffrey V, Rubiano, Andres M, Sahuquillo, Juan, Servadei, Franco, Shutter, Lori, Stein, Deborah, Stocchetti, Nino, Taccone, Fabio Silvio, Timmons, Shelly, Tsai, Eve, Ullman, Jamie S, Vespa, Paul, Videtta, Walter, Wright, David W, Zammit, Christopher, and Hawryluk, Gregory WJ

Subjects
Algorithm, Brain injury, Brain oxygen, Consensus, Head trauma, Intracranial pressure, PbtO2, Protocol, SIBICC, Seattle, Tiers, Emergency & Critical Care Medicine, Clinical Sciences, Public Health and Health Services
Abstract

BackgroundCurrent guidelines for the treatment of adult severe traumatic brain injury (sTBI) consist of high-quality evidence reports, but they are no longer accompanied by management protocols, as these require expert opinion to bridge the gap between published evidence and patient care. We aimed to establish a modern sTBI protocol for adult patients with both intracranial pressure (ICP) and brain oxygen monitors in place.MethodsOur consensus working group consisted of 42 experienced and actively practicing sTBI opinion leaders from six continents. Having previously established a protocol for the treatment of patients with ICP monitoring alone, we addressed patients who have a brain oxygen monitor in addition to an ICP monitor. The management protocols were developed through a Delphi-method-based consensus approach and were finalized at an in-person meeting.ResultsWe established three distinct treatment protocols, each with three tiers whereby higher tiers involve therapies with higher risk. One protocol addresses the management of ICP elevation when brain oxygenation is normal. A second addresses management of brain hypoxia with normal ICP. The third protocol addresses the situation when both intracranial hypertension and brain hypoxia are present. The panel considered issues pertaining to blood transfusion and ventilator management when designing the different algorithms.ConclusionsThese protocols are intended to assist clinicians in the management of patients with both ICP and brain oxygen monitors but they do not reflect either a standard-of-care or a substitute for thoughtful individualized management. These protocols should be used in conjunction with recommendations for basic care, management of critical neuroworsening and weaning treatment recently published in conjunction with the Seattle International Brain Injury Consensus Conference.

Published
2020

19. IgG antibody response to pneumococcal-conjugated vaccine (Prevenar®13) in children with immunodeficiency disorders

Author

Garrido-Jareño, Marta, Sahuquillo-Arce, José Miguel, Rodríguez-Vega, Héctor, Lloret-Sos, Carmen, Gil-Brusola, Ana, López-Hontangas, José Luis, Nuñez-Beltran, María, Tortosa-Carreres, Jordi, García-García, José Ángel, Cordón, Lourdes, Puchades-Carrasco, Leonor, de Santivañes, Carmen Carreras-Gil, Pineda-Lucena, Antonio, and Pemán-García, Javier

Published
2023
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24. Role of Sulfonylurea Receptor 1 and Glibenclamide in Traumatic Brain Injury: A Review of the Evidence.

Author

Jha, Ruchira M, Bell, Josh, Citerio, Giuseppe, Hemphill, J Claude, Kimberly, W Taylor, Narayan, Raj K, Sahuquillo, Juan, Sheth, Kevin N, and Simard, J Marc

Subjects
Animals, Humans, Glyburide, TRPM Cation Channels, Clinical Trials as Topic, Genetic Variation, Sulfonylurea Receptors, Brain Injuries, Traumatic, ASTRAL, SUR1, TBI, TRPM4, cerebral edema, contusion expansion, glibenclamide, glyburide, Brain Injuries, Traumatic, Other Chemical Sciences, Genetics, Other Biological Sciences, Chemical Physics
Abstract

Cerebral edema and contusion expansion are major determinants of morbidity and mortality after TBI. Current treatment options are reactive, suboptimal and associated with significant side effects. First discovered in models of focal cerebral ischemia, there is increasing evidence that the sulfonylurea receptor 1 (SUR1)-Transient receptor potential melastatin 4 (TRPM4) channel plays a key role in these critical secondary injury processes after TBI. Targeted SUR1-TRPM4 channel inhibition with glibenclamide has been shown to reduce edema and progression of hemorrhage, particularly in preclinical models of contusional TBI. Results from small clinical trials evaluating glibenclamide in TBI have been encouraging. A Phase-2 study evaluating the safety and efficacy of intravenous glibenclamide (BIIB093) in brain contusion is actively enrolling subjects. In this comprehensive narrative review, we summarize the molecular basis of SUR1-TRPM4 related pathology and discuss TBI-specific expression patterns, biomarker potential, genetic variation, preclinical experiments, and clinical studies evaluating the utility of treatment with glibenclamide in this disease.

Published
2020

25. A management algorithm for patients with intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC).

Author

Hawryluk, Gregory WJ, Aguilera, Sergio, Buki, Andras, Bulger, Eileen, Citerio, Giuseppe, Cooper, D Jamie, Arrastia, Ramon Diaz, Diringer, Michael, Figaji, Anthony, Gao, Guoyi, Geocadin, Romergryko, Ghajar, Jamshid, Harris, Odette, Hoffer, Alan, Hutchinson, Peter, Joseph, Mathew, Kitagawa, Ryan, Manley, Geoffrey, Mayer, Stephan, Menon, David K, Meyfroidt, Geert, Michael, Daniel B, Oddo, Mauro, Okonkwo, David, Patel, Mayur, Robertson, Claudia, Rosenfeld, Jeffrey V, Rubiano, Andres M, Sahuquillo, Juan, Servadei, Franco, Shutter, Lori, Stein, Deborah, Stocchetti, Nino, Taccone, Fabio Silvio, Timmons, Shelly, Tsai, Eve, Ullman, Jamie S, Vespa, Paul, Videtta, Walter, Wright, David W, Zammit, Christopher, and Chesnut, Randall M

Subjects
Humans, Intracranial Hypertension, Monitoring, Physiologic, Algorithms, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Consensus Development Conferences as Topic, Practice Guidelines as Topic, Brain Injuries, Traumatic, Algorithm, Brain injury, Consensus, Head trauma, Intracranial pressure, Protocol, SIBICC, Seattle, Tiers, Traumatic Brain Injury (TBI), Neurosciences, Traumatic Head and Spine Injury, Brain Disorders, Physical Injury - Accidents and Adverse Effects, Clinical Sciences, Public Health and Health Services, Emergency & Critical Care Medicine
Abstract

BackgroundManagement algorithms for adult severe traumatic brain injury (sTBI) were omitted in later editions of the Brain Trauma Foundation's sTBI Management Guidelines, as they were not evidence-based.MethodsWe used a Delphi-method-based consensus approach to address management of sTBI patients undergoing intracranial pressure (ICP) monitoring. Forty-two experienced, clinically active sTBI specialists from six continents comprised the panel. Eight surveys iterated queries and comments. An in-person meeting included whole- and small-group discussions and blinded voting. Consensus required 80% agreement. We developed heatmaps based on a traffic-light model where panelists' decision tendencies were the focus of recommendations.ResultsWe provide comprehensive algorithms for ICP-monitor-based adult sTBI management. Consensus established 18 interventions as fundamental and ten treatments not to be used. We provide a three-tier algorithm for treating elevated ICP. Treatments within a tier are considered empirically equivalent. Higher tiers involve higher risk therapies. Tiers 1, 2, and 3 include 10, 4, and 3 interventions, respectively. We include inter-tier considerations, and recommendations for critical neuroworsening to assist the recognition and treatment of declining patients. Novel elements include guidance for autoregulation-based ICP treatment based on MAP Challenge results, and two heatmaps to guide (1) ICP-monitor removal and (2) consideration of sedation holidays for neurological examination.ConclusionsOur modern and comprehensive sTBI-management protocol is designed to assist clinicians managing sTBI patients monitored with ICP-monitors alone. Consensus-based (class III evidence), it provides management recommendations based on combined expert opinion. It reflects neither a standard-of-care nor a substitute for thoughtful individualized management.

Published
2019

26. Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma* [S]

Author

Shraibman, Bracha, Barnea, Eilon, Kadosh, Dganit Melamed, Haimovich, Yael, Slobodin, Gleb, Rosner, Itzhak, López-Larrea, Carlos, Hilf, Norbert, Kuttruff, Sabrina, Song, Colette, Britten, Cedrik, Castle, John, Kreiter, Sebastian, Frenzel, Katrin, Tatagiba, Marcos, Tabatabai, Ghazaleh, Dietrich, Pierre-Yves, Dutoit, Valérie, Wick, Wolfgang, Platten, Michael, Winkler, Frank, von Deimling, Andreas, Kroep, Judith, Sahuquillo, Juan, Martinez-Ricarte, Francisco, Rodon, Jordi, Lassen, Ulrik, Ottensmeier, Christian, van der Burg, Sjoerd H, Thor Straten, Per, Poulsen, Hans Skovgaard, Ponsati, Berta, Okada, Hideho, Rammensee, Hans-Georg, Sahin, Ugur, Singh, Harpreet, and Admon, Arie

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Clinical Research, Rare Diseases, Brain Disorders, Neurosciences, Brain Cancer, Cancer, Good Health and Well Being, Alleles, Antigens, Neoplasm, Biomarkers, Tumor, Brain Neoplasms, Glioblastoma, Histocompatibility Antigens Class I, Humans, Peptides, Proteome, CTA, Cancer Biomarker(s), Cancer Therapeutics, HLA, Immunoaffinity, Immunotherapy, MHC, Peptidomics, Plasma or Serum Analysis, Biochemistry & Molecular Biology
Abstract

Glioblastoma multiforme (GBM) is the most aggressive brain tumor with poor prognosis to most patients. Immunotherapy of GBM is a potentially beneficial treatment option, whose optimal implementation may depend on familiarity with tumor specific antigens, presented as HLA peptides by the GBM cells. Further, early detection of GBM, such as by a routine blood test, may improve survival, even with the current treatment modalities. This study includes large-scale analyses of the HLA peptidome (immunopeptidome) of the plasma-soluble HLA molecules (sHLA) of 142 plasma samples, and the membranal HLA of GBM tumors of 10 of these patients' tumor samples. Tumor samples were fresh-frozen immediately after surgery and the plasma samples were collected before, and at multiple visits after surgery. In total, this HLA peptidome analysis involved 52 different HLA allotypes and resulted in the identification of more than 35,000 different HLA peptides. Strong correlations were observed in the signal intensities and in the repertoires of identified peptides between the tumors and plasma-soluble HLA peptidomes of the individual patients, whereas low correlations were observed between these HLA peptidomes and the tumors' proteomes. HLA peptides derived from Cancer/Testis Antigens (CTAs) were selected based on their presence among the HLA peptidomes of the patients and absence of expression of their source genes from any healthy and essential human tissues, except from immune-privileged sites. Additionally, peptides were selected as potential biomarkers if their levels in the plasma-sHLA peptidome were significantly reduced after the removal of tumor mass. The CTAs identified among the analyzed HLA peptidomes provide new opportunities for personalized immunotherapy and for early diagnosis of GBM.

Published
2019

30. Diagnosis and treatment of Chiari malformation type 1 in children: the International Consensus Document

Author

Massimi, Luca, Peretta, Paola, Erbetta, Alessandra, Solari, Alessandra, Farinotti, Mariangela, Ciaramitaro, Palma, Saletti, Veronica, Caldarelli, Massimo, Canheu, Alexandre Casagrande, Celada, Carlo, Chiapparini, Luisa, Chieffo, Daniela, Cinalli, Giuseppe, Di Rocco, Federico, Furlanetto, Marika, Giordano, Flavio, Jallo, George, James, Syril, Lanteri, Paola, Lemarchand, Christian, Messing-Jünger, Martina, Parazzini, Cecilia, Paternoster, Giovanna, Piatelli, Gianluca, Poca, Maria. A., Prabahkar, Prab, Ricci, Federica, Righini, Andrea, Sala, Francesco, Sahuquillo, Juan, Stoodley, Marcus, Talamonti, Giuseppe, Thompson, Dominic, Triulzi, Fabio, Zucchelli, Mino, and Valentini, Laura

Published
2022
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31. Diagnosis and treatment of Chiari malformation and syringomyelia in adults: international consensus document

Author

Ciaramitaro, Palma, Massimi, Luca, Bertuccio, Alessandro, Solari, Alessandra, Farinotti, Mariangela, Peretta, Paola, Saletti, Veronica, Chiapparini, Luisa, Barbanera, Andrea, Garbossa, Diego, Bolognese, Paolo, Brodbelt, Andrew, Celada, Carlo, Cocito, Dario, Curone, Marcella, Devigili, Grazia, Erbetta, Alessandra, Ferraris, Marilena, Furlanetto, Marika, Gilanton, Mado, Jallo, George, Karadjova, Marieta, Klekamp, Jorg, Massaro, Fulvio, Morar, Sylvia, Parker, Fabrice, Perrini, Paolo, Poca, Maria Antonia, Sahuquillo, Juan, Stoodley, Marcus, Talamonti, Giuseppe, Triulzi, Fabio, Valentini, Maria Consuelo, Visocchi, Massimiliano, and Valentini, Laura

Published
2022
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32. Harmonized D-dimer levels upon admission for prognosis of COVID-19 severity: Results from a Spanish multicenter registry (BIOCOVID-Spain study)

Author

García de Guadiana-Romualdo, Luis, Morell-García, Daniel, Favaloro, Emmanuel J., Vílchez, Juan A., Bauça, Josep M., Alcaide Martín, María J., Gutiérrez Garcia, Irene, de la Hera Cagigal, Patricia, Egea-Caparrós, José Manuel, Pérez Sanmartín, Sonia, Gutiérrez Revilla, José I., Urrechaga, Eloísa, Álamo, Jose M., Hernando Holgado, Ana M., Lorenzo-Lozano, María-Carmen, Canalda Campás, Magdalena, Juncos Tobarra, María A., Morales-Indiano, Cristian, Vírseda Chamorro, Isabel, Pastor Murcia, Yolanda, Sahuquillo Frías, Laura, Altimira Queral, Laura, Nuez-Zaragoza, Elisa, Adell Ruiz de León, Juan, Ruiz Ripa, Alicia, Salas Gómez-Pablos, Paloma, Cebreiros López, Iria, Fernández Uriarte, Amaia, Larruzea, Alex, López Yepes, María L., Sancho-Rodríguez, Natalia, Zamorano Andrés, María C., Pedregosa Díaz, José, Sáenz, Luis, Esparza del Valle, Clara, Baamonde Calzada, María C., García Muñoz, Sara, Vera, Marina, Martín Torres, Esther, Sánchez Fdez-Pacheco, Silvia, Vicente Gutiérrez, Luis, Jiménez Añón, Laura, Pérez Martínez, Alfonso, Pons Castillo, Aurelio, González Tamayo, Ruth, Férriz Vivancos, Jorge, Rodríguez-Fraga, Olaia, Díaz-Brito, Vicens, Aguadero, Vicente, García Arévalo, M. G., Arnaldos Carrillo, María, González Morales, Mercedes, Núñez Gárate, María, Ruiz Iruela, Cristina, Esteban Torrella, Patricia, Vila Pérez, Martí, Acevedo Alcaraz, Cristina, Blázquez-Manzanera, Alfonso L., and Galán Ortega, Amparo

Published
2022
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33. Multicenter Retrospective Study of Secukinumab Drug Survival in Psoriasis Patients in a Daily Practice Setting: A Long-Term Experience in Spain

Author

Daudén, Esteban, de Lima, Glauber Pacelli Gomes, Armesto, Susana, Herrera-Acosta, Enrique, Vidal, David, Villarasa, Eva, Rivera, Raquel, de la Cueva, Pablo, Martorell, Antonio, Ballesca, Ferran, Belinchón, Isabel, Carretero, Gregorio, Rodríguez, Lourdes, Romero-Maté, Alberto, Pujol-Montcusí, Josep, Salgado, Laura, Sahuquillo-Torralba, Antonio, Coto-Segura, Pablo, Baniandrés, Ofelia, Feltes, Rosa, Alsina, Mercé, and Llamas-Velasco, Mar

Published
2021
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37. Attentional Patterns to Emotional Faces versus Scenes in Children with Autism Spectrum Disorders

Author

Ghosn, Farah, Perea, Manuel, Castelló, Javier, Vázquez, Miguel Ángel, Yáñez, Núria, Marcos, Inmaculada, Sahuquillo, Rosa, Vento, Máximo, and García-Blanco, Ana

Abstract

Previous research has shown attentional biases in children with autism spectrum disorders (ASD) when processing distressing information. This study examined these attentional patterns as a function of the type of stimulus (scenes and faces) and the stimulus valence (happy, sad, threatening, neutral) using a within-subject design. A dot-probe was applied to ASD (n = 24) and typically developing (TD) children (n = 24). Results showed no differences between the groups for happy and sad stimuli. Critically, ASD children showed an attentional bias toward threatening scenes but away from threatening faces. Thus, the type of stimuli modulated the direction of attentional biases to distressing information in ASD children. These results are discussed in the framework of current theories on cognitive and emotional processing in ASD.

Published
2019
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39. A GIS-supported Multidisciplinary Database for the Management of UNESCO Global Geoparks: the Courel Mountains Geopark (Spain)

Author

Ballesteros, Daniel, Caldevilla, Pablo, Vila, Ramón, Barros, Xosé Carlos, Rodríguez-Rodríguez, Laura, García-Ávila, Manuel, Sahuquillo, Elvira, Llorente, Miguel, Diez, José Bienvenido, Fuertes-Fuente, Mercedes, Timón-Sánchez, Susana M., de Lombera-Hermida, Arturo, Álvarez, Iván, Pérez-Cáceres, Irene, Acebo, Manuel, Orche Amaré, Pilar, García, J. Horacio, Martín-González, Fidel, and Alemparte, Martín

Published
2022
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43. Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment

Author

Rubio-Perez, Carlota, Planas-Rigol, Ester, Trincado, Juan L., Bonfill-Teixidor, Ester, Arias, Alexandra, Marchese, Domenica, Moutinho, Catia, Serna, Garazi, Pedrosa, Leire, Iurlaro, Raffaella, Martínez-Ricarte, Francisco, Escudero, Laura, Cordero, Esteban, Cicuendez, Marta, Ruiz, Sara, Parra, Genís, Nuciforo, Paolo, Gonzalez, Josep, Pineda, Estela, Sahuquillo, Juan, Tabernero, Josep, Heyn, Holger, and Seoane, Joan

Published
2021
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45. Clinical and Imaging Characteristics, Care Pathways, and Outcomes of Traumatic Epidural Hematomas: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Study

Author

Pisică, Dana, Volovici, Victor, Yue, John K., van Essen, Thomas A., den Boogert, Hugo F., Vande Vyvere, Thijs, Haitsma, Iain, Nieboer, Daan, Markowitz, Amy J., Yuh, Esther L., Steyerberg, Ewout W., Peul, Wilco C., Dirven, Clemens M. F., Menon, David K., Manley, Geoffrey T., Maas, Andrew I. R., Lingsma, Hester F., Åkerlund, Cecilia, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Clusmann, Hans, Coburn, Mark, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Čović, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dark, Paul, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, Boogert, Hugo den, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubovic, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Hutchinson, Peter J., Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Ji-yao, Johnson, Faye, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Kornaropoulos, Evgenios, Koskinen, Lars-Owe, Kovács, Noémi, Kowark, Ana, Lagares, Alfonso, Lanyon, Linda, Laureys, Steven, Lecky, Fiona, Ledoux, Didier, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Lingsma, Hester, Maas, Andrew I. R., Castaño-León, Ana M., Maegele, Marc, Majdan, Marek, Manara, Alex, Manley, Geoffrey, Martino, Costanza, Maréchal, Hugues, Mattern, Julia, McMahon, Catherine, Melegh, Béla, Menon, David, Menovsky, Tomas, Mikolic, Ana, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nieboer, Daan, Nyirádi, József, Olubukola, Otesile, Oresic, Matej, Ortolano, Fabrizio, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Pirinen, Matti, Pisica, Dana, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Radoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Helmrich, Isabel Retel, Rhodes, Jonathan, Richardson, Sylvia, Richter, Sophie, Ripatti, Samuli, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosand, Jonathan, Rosenfeld, Jeffrey V., Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, Sanchez-Porras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Sewalt, Charlie, Singh, Ranjit D., Skandsen, Toril, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Stevens, Robert, Stewart, William, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Ao, Braden Te, Tenovuo, Olli, Theadom, Alice, Thomas, Matt, Tibboel, Dick, Timmers, Marjolein, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Vallance, Shirley, Valeinis, Egils, Vámos, Zoltán, van der Jagt, Mathieu, Van der Steen, Gregory, van der Naalt, Joukje, van Dijck, Jeroen T. J. M., van Erp, Inge A. M., van Essen, Thomas A., Van Hecke, Wim, van Heugten, Caroline, Van Praag, Dominique, van Veen, Ernest, Vande Vyvere, Thijs, van Wijk, Roel P. J., Vargiolu, Alessia, Vega, Emmanuel, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Petar, Wang, Kevin K.W., Whitehouse, Daniel, Wiegers, Eveline, Williams, Guy, Wilson, Lindsay, Winzeck, Stefan, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Younsi, Alexander, Zeiler, Frederick A., Zelinkova, Veronika, Ziverte, Agate, and Zoerle, Tommaso

Published
2024
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47. Correction to: Diagnosis and treatment of Chiari Malformation and syringomyelia in adults: International Consensus Document

Author

Ciaramitaro, Palma, Massimi, Luca, Bertuccio, Alessandro, Solari, Alessandra, Farinotti, Mariangela, Peretta, Paola, Saletti, Veronica, Chiapparini, Luisa, Barbanera, Andrea, Garbossa, Diego, Bolognese, Paolo, Brodbelt, Andrew, Celada, Carlo, Cocito, Dario, Curone, Marcella, Devigili, Grazia, Erbetta, Alessandra, Ferraris, Marilena, Furlanetto, Marika, Gilanton, Mado, Jallo, George, Karadjova, Marieta, Klekamp, Jorg, Massaro, Fulvio, Morar, Sylvia, Parker, Fabrice, Perrini, Paolo, Poca, Maria Antonia, Sahuquillo, Juan, Stoodley, Marcus, Talamonti, Giuseppe, Triulzi, Fabio, Valentini, Maria Consuelo, Visocchi, Massimiliano, and Valentini, Laura

Published
2022
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49. Preface

Author

Rosaler, Joshua, Harlander, Robert, Schiemann, Gregor, and Carretero Sahuquillo, Miguel Ángel

Published
2019
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