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2. Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair

Author

Perez-Bermejo, Juan A., Efagene, Oghene, Matern, William M., Holden, Jeffrey K., Kabir, Shaheen, Chew, Glen M., Andreoletti, Gaia, Catton, Eniola, Ennis, Craig L., Garcia, Angelica, Gerstenberg, Trevor L., Hill, Kaisle A., Jain, Aayami, Krassovsky, Kristina, Lalisan, Cassandra D., Lord, Daniel, Quejarro, B. Joy, Sales-Lee, Jade, Shah, Meet, Silva, Brian J., Skowronski, Jason, Strukov, Yuri G., Thomas, Joshua, Veraz, Michael, Vijay, Twaritha, Wallace, Kirby A., Yuan, Yue, Grogan, Jane L., Wienert, Beeke, Lahiri, Premanjali, Treusch, Sebastian, Dever, Daniel P., Soros, Vanessa B., Partridge, James R., and Seim, Kristen L.

Published
2024
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4. Establishing a Per-Hour Rate for Early-Career Adult Reconstruction Surgeons Performing Medicare Primary Total Joint Arthroplasty

Author

Evan Catton, MD, Alan Puddy, MD, Vineet Tyagi, MD, Gregory M. Kurkis, MD, and David N. Shau, MD, MBA

Subjects
Total joint arthroplasty, Primary total joint arthroplasty, Per-hour rate, Early-career, Medicare, Orthopedic surgery, RD701-811
Abstract

Background: There is a paucity of data regarding compensation for early-career adult reconstruction surgeons. This study aims to quantify the time throughout the full episode of care for a Medicare primary total hip/knee arthroplasty and convert to per-hour pay for early-career arthroplasty surgeons at various geographic locations and practice settings. Using Center for Medicare and Medicaid Services data, this study also compares the compensation of early-career vs established total joint arthroplasty (TJA) surgeons. Methods: Between January 2022 and January 2023, 3 early-career surgeons in 3 different locations collected prospective data on time spent in patient care during the global period following primary TJAs (pTJAs). A weighted average time spent per pTJA during global period was calculated with the 2024 work relative value unit and conversion factor to establish a per-hour rate. This rate was compared to the compensation rates of other healthcare-related fields and established TJA surgeons using Relative Value Scale Update Committee (RUC) values. Results: A total of 334 pTJAs (148 hips and 186 knees) were performed among 3 surgeons, and per-hour rates of $87.62 and $87.70 were found, respectively. These are less than hospital/healthcare system/health insurance/med tech CEOs, lawyers, dentists, and travel nurses. Early-career TJA surgeons were found to take 7.98%-8.68% longer than RUC standard times for a TJA episode of care. Conclusions: This study quantifies the per-hour compensation of early-career arthroplasty surgeons, who earn lower compensation rates to travel nurses and take longer than Center for Medicare and Medicaid Services RUC times for pTJAs. Given the increasing demand for pTJAs, decreasing reimbursement rates, and concern over burnout, access to quality pTJA care for patients is concerning.

Published
2024
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5. Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair

Author

Juan A. Perez-Bermejo, Oghene Efagene, William M. Matern, Jeffrey K. Holden, Shaheen Kabir, Glen M. Chew, Gaia Andreoletti, Eniola Catton, Craig L. Ennis, Angelica Garcia, Trevor L. Gerstenberg, Kaisle A. Hill, Aayami Jain, Kristina Krassovsky, Cassandra D. Lalisan, Daniel Lord, B. Joy Quejarro, Jade Sales-Lee, Meet Shah, Brian J. Silva, Jason Skowronski, Yuri G. Strukov, Joshua Thomas, Michael Veraz, Twaritha Vijay, Kirby A. Wallace, Yue Yuan, Jane L. Grogan, Beeke Wienert, Premanjali Lahiri, Sebastian Treusch, Daniel P. Dever, Vanessa B. Soros, James R. Partridge, and Kristen L. Seim

Subjects
Science
Abstract

Abstract Homology Directed Repair (HDR) enables precise genome editing, but the implementation of HDR-based therapies is hindered by limited efficiency in comparison to methods that exploit alternative DNA repair routes, such as Non-Homologous End Joining (NHEJ). In this study, we develop a functional, pooled screening platform to identify protein-based reagents that improve HDR in human hematopoietic stem and progenitor cells (HSPCs). We leverage this screening platform to explore sequence diversity at the binding interface of the NHEJ inhibitor i53 and its target, 53BP1, identifying optimized variants that enable new intermolecular bonds and robustly increase HDR. We show that these variants specifically reduce insertion-deletion outcomes without increasing off-target editing, synergize with a DNAPK inhibitor molecule, and can be applied at manufacturing scale to increase the fraction of cells bearing repaired alleles. This screening platform can enable the discovery of future gene editing reagents that improve HDR outcomes.

Published
2024
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6. The Trend of Medicare Reimbursement for Total Joint Arthroplasty: Using Mathematical Models to Predict Possible Per-Hour Rate Out to 2030

Author

Evan Catton, MD, Alan Puddy, MD, Vineet Tyagi, MD, Gregory M. Kurkis, MD, and David N. Shau, MD, MBA

Subjects
Reimbursement, Total joint arthroplasty, Total knee arthroplasty, Total hip arthroplasty, Per-hour income, Medicare, Orthopedic surgery, RD701-811
Abstract

Background: While multiple studies have assessed the trends of Medicare reimbursement for orthopedic total joint arthroplasty (TJA) surgeries, none have forecasted reimbursement in relatable per-hour figures. The purposes of this study are to examine trends of reimbursement for primary and revision TJA and translate forecasted primary TJA reimbursement to relatable per-hour compensation. Methods: The Center for Medicare and Medicaid Services reimbursement data from 1992 to 2024 were used to create a historical view of reimbursement for primary and revision TJA. All monetary values were converted to 2023 USD to account for inflation. Polynomial and linear forecast equations were used to predict the future of the TJA reimbursement to 2030. Relative Value Scale Update Committee standard times for procedures were used with the forecasts to establish per-hour rates. Results: Total reimbursement for primary total hip arthroplasty/total knee arthroplasty is forecasted to decrease 85.36%/86.14% by 2030. Using prior trends in reimbursement, TJA procedures are predicted to reimburse at or less than $100.00 2023 USD per Medicare case by 2030. Moreover, TJA surgeons are forecasted to earn $13.93/h per primary total hip arthroplasty and $14.97/h per primary total knee arthroplasty by 2030. Conclusions: This study highlights the concerning trends for both primary and revision arthroplasties as TJA surgeons are on a path to earn below minimum wage for primary TJAs by 2030. Mathematical models forecast a bleak future for orthopedic TJA reimbursement. This downward trajectory poses a risk to access and quality of care.

Published
2024
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8. Changes in household food security, access to health services and income in northern Lao PDR during the COVID-19 pandemic: a cross-sectional survey

Author

Head, Jennifer R, Chanthavilay, Phetsavanh, Catton, Helen, Vongsitthi, Ammaline, Khamphouxay, Kelley, and Simphaly, Niphone

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Health Sciences, Pediatric, Nutrition, Prevention, Behavioral and Social Science, Zero Hunger, COVID-19, Child, Child, Preschool, Cross-Sectional Studies, Family Characteristics, Female, Food Security, Food Supply, Health Services Accessibility, Humans, Laos, Pandemics, epidemiology, public health, nutrition & dietetics, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

ObjectivesWe assessed the relative difficulty in meeting food needs during the COVID-19 pandemic compared with before; determined the relationship between pandemic-associated difficulties in food access and household, maternal and child food security; and identified resiliency-promoting strategies.DesignA cross-sectional survey of households undertaken in November 2020.SettingRural districts of Luang Prabang Province, Lao People's Democratic Republic.ParticipantsHouseholds (N=1122) with children under 5 years.Primary and secondary outcomes measuredSurvey respondents reported the relative ease of access of food and healthcare as well as changes in income and expenditures compared with before March 2020. We determined indicators of food security and source of foods consumed for households, women and children, as well as prevalence of malnutrition in children under 5.ResultsNearly four-fifths (78.5%) found it harder to meet household food needs during the pandemic. The most common reasons were increased food prices (51.2%), loss of income (45.3%) and decreased food availability (36.6%). Adjusting for demographics, households with increased difficulty meeting food needs had lower food consumption scores and child dietary diversity. Over 85% of households lost income during the pandemic. Decreased expenditures was associated with reliance on more extreme coping strategies to meet food needs. The households who experienced no change in meeting food needs produced a greater percentage of their food from homegrown methods (4.22% more, 95% CI 1.28 to 7.15), than households who found it more difficult.ConclusionsPandemic-associated shocks may have large effects on food insecurity. Action is needed to mitigate consequences of the pandemic on nutrition. Local food production and safety net programmes that offset income losses may help.

Published
2022

12. ‘I Just Filled Out a Form’ Experiences of Doctoral Students with Disabilities, Long-Term Health Conditions and/or Additional Study Needs

Author

Gráinne O’Connor, Lindsay O’Dell, Inma Alvarez, Nicoleta Tipi, Helen Bowes-Catton, and Rachael Luck

Subjects
doctoral students, disabilities, long term health conditions, neurodivergent pgr, study needs, higher education, Social sciences (General), H1-99
Abstract

This paper reports on an empirical study at a public university in the UK. The project explored the lived experiences of doctoral students with disabilities, long-term health conditions, and/or additional study needs. Taking a critical disability studies lens, we investigated how students perceive the university’s social and institutional structures. We used a mixed methods methodology using a survey and semi-structured interviews and adopted a reflexive thematic analysis to discover emerging themes. Three main themes were identified from the students’ data, namely, diversity in disability identity, the impact of supervisors’ attitudes (disclosure, emotional, institutional), and barriers to study. We argue that universities are implicitly organised around the needs of non-disabled, ‘normative’ students, hence perpetuating disadvantage and stigma. The paper makes suggestions for changes to institutions and processes to equitably support disabled doctoral students.

Published
2024
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13. Detection of SARS-CoV-2 BA.2.86 by lateral flow devices

Author

Abbie Bown, Angela Sweed, Matthew Catton, Joshua Nelthorpe-Cowne, Hermione Conti-Frith, Ruth Elderfield, Jacob Terrey, Hamsa Abib, Caleb Lui, Ella Fisher, Kevin R. Bewley, Naomi S. Coombes, Donna Robinson, Somya Agrawal, Bassam Hallis, Edward Blandford, Tom Fowler, Deborah A. Williamson, and Richard Vipond

Subjects
SARS-COV-2, BA.2.86, lateral flow device, LFD, Infectious and parasitic diseases, RC109-216
Abstract

We evaluated the performance of 12 lateral flow devices by assessing their analytical sensitivity for SARS-CoV-2 variant BA.2.86. Kits from ACON, Orient Gene, Xiamen Biotime, Getein, and SureScreen detected variant BA.2.86 to sufficient sensitivity levels, comparable to those observed with previous Omicron variants. The stocks of lateral flow devices currently held by the UK government do not currently need changing for deployment for this variant.

Published
2024
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14. Clinical and dosimetric outcomes of image-guided, dose-painted radiotherapy in muscle invasive bladder cancer

Author

Inmaculada Navarro-Domenech, Shinthujah Arulanantham, Zhihui Amy Liu, Michael Tjong, Vickie Kong, Victor Malkov, Tony Tadic, Neil Fleshner, Girish Kulkarni, Alexandre R Zlotta, Charles Catton, Alejandro Berlin, Srikala Sridhar, Di (Maria) Jiang, Peter Chung, and Srinivas Raman

Subjects
Bladder cancer, Radiotherapy, Dose-painted, Lipiodol, Tri-modal therapy, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Purpose/Objective Definitive radiotherapy (RT) is an alternative to radical cystectomy for select patients with muscle invasive bladder cancer (MIBC); however, there is limited data on dose-painted RT approaches. We report the clinical and dosimetric outcomes of a cohort of MIBC patients treated with dose-painted RT. Material/Methods This was a single institution retrospective study of cT2-4N0M0 MIBC patients treated with external beam radiotherapy (EBRT) to the bladder, and sequential or concomitant boost to the tumor bed. The target delineation was guided by either intravesical injection of Lipiodol or through fusion of the pre-treatment imaging. The majority were treated with daily image-guidance. Kaplan-Meier was used to characterize overall survival (OS) and progression-free survival (PFS). Cumulative incidence function (CIF) was used to estimate local (intravesical) recurrence (LR), regional recurrence (RR) and distant metastasis (DM). Univariable and multivariable cause-specific hazard model was used to assess factors associated with LR and OS. Results 117 patients were analyzed. The median age was 73 years (range 43, 95). The median EQD2 to the boost volume was 66 Gy (range 52.1, 70). Lipiodol injection was used in 64 patients (55%), all treated with IMRT/VMAT. 95 (81%) received concurrent chemotherapy, of whom, 44 (38%) received neoadjuvant chemotherapy. The median follow-up was 37 months (IQR 16.2, 83.3). At 5-year, OS and PFS were 79% (95% CI 70.5–89.2) and 46% (95% CI 36.5–57.5). Forty-five patients had bladder relapse, of which 30 patients (67%) were at site of the tumor bed. Nine patients underwent salvage-cystectomy. Late high-grade (G3-G4) genitourinary and gastrointestinal toxicity were 3% and 1%. Conclusion Partial boost RT in MIBC is associated with good local disease control and high rates of cystectomy free survival. We observed a pattern of predominantly LR in the tumor bed, supporting the use of a dose-painted approach/de-escalation strategy to the uninvolved bladder. Prospective trials are required to compare oncological and toxicity outcomes between dose-painted and homogeneous bladder RT techniques.

Published
2023
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16. Treatment Preferences in Young Adults with Moderate to Severe Psoriasis: A Qualitative Study from the Nordic Countries

Author

Flora Nicol Balieva, Louise Catton, Birgitta W. Claréus, Kjersti Danielsen, Frederik Fierens, Lars Iversen, Leena Koulu, Amra Osmanecevic, Rafael Pasternack, and Lone Skov

Subjects
Disease burden, Patient preference, Semistructured interviews, Treatment attributes, Treatment burden, Dermatology, RL1-803
Abstract

Abstract Introduction The purpose of this study is to explore treatment preferences and identify patient characteristics in young bio-naive adults with moderate to severe psoriasis in the Nordic countries (Norway, Finland, Sweden, and Denmark). Methods Patients were 18–45 years old and bio-naive but referred for biologic treatment of moderate to severe psoriasis. Patients were included at eight Nordic dermatology clinics. Patients with significant comorbidity or psoriatic arthritis were excluded. The Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) were assessed along with basic patient information. A semistructured interview guide was used in individual qualitative interviews, asking patients about their treatment preferences and reasons, disease journey, and disease management. The interviews were analyzed using thematic content analysis. Twenty-four patients sufficed to reach saturation in this qualitative study. Results The patient sample characteristics represented a qualitative variation in age, sex, symptoms, duration of disease, and country. We included a total of 12 male and 12 female patients. The mean age was 34 years (range 18–45 years), the mean age at diagnosis was 20 years (range 6–34 years), the mean ± standard deviation (SD) time since diagnosis was 13 ± 8 years, PASI was 9.5 ± 4.7, and DLQI was 15.2 ± 6.4. Interviews suggested that both the burden of disease as well as the burden of treatment influenced patient preferences regarding treatment attributes, hence getting alleviation from symptoms did not alone influence patient preferences. Time, effort, and inconvenience related to psoriasis treatments also influenced patient preferences. Conclusions This first in-depth, qualitative study in young bio-naive adults with psoriasis suggests that patient preferences are focusing not only on symptom relief but also on alleviating the burden of psoriasis treatment. Understanding the reasons for patient preferences and the perspectives of young adults is needed to guide individual shared decision-making in psoriasis management.

Published
2023
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17. In vitro characterization of novel hyaluronan-antioxidant conjugates as potential topical therapeutics against hearing loss

Author

Elizabeth M. Arrigali, Joachim G. S. Veit, Bhaskar Birru, Jack Van Tine, Kolton C. Sandau, Emma Barrett-Catton, Zachary Tonnerre, and Monica A. Serban

Subjects
oxidative stress, hyaluronan, hearing loss, ototherapeutic, antioxidant, Therapeutics. Pharmacology, RM1-950
Abstract

Noise-induced hearing loss affects roughly 430 million people worldwide. Current treatment options often require invasive medical procedures, and to date, there are no FDA-approved drug therapies. While the causes can be diverse, noise induced hearing loss is unequivocally associated with oxidative stress and inflammation, and subsequent damage to the inner ear structures. Several studies have shown that various antioxidants such as glutathione, cysteine, and methionine can be used to mitigate oxidative damage from reactive oxygen species; however, these studies relied on invasive or systemic drug delivery methods. This study focused on the development and characterization of a novel series of antioxidant compounds that would be suitable for non or minimally invasive topical inner ear delivery and could mitigate reactive oxygen species associated cellular damage. Specifically, a series of covalent conjugates were synthesized by using hyaluronan as a drug carrier, and methionine, cysteine or glutathione as antioxidant drugs. The conjugates were tested for their ability to readily permeate though in vitro round window membrane and tympanic membrane permeation models, as well as their in vitro internalization into cochlear cells. Our data revealed interdependence between the molecular weight of the hyaluronan carrier, and the tissue and cellular membrane permeation capacity. Subsequent screening of the adequately sized conjugates in in vitro acellular assays revealed the strongest antioxidant activity for the cysteine and glutathione conjugates. These oxidative stress protective effects were further confirmed in cellular in vitro assays. Collectively, the data herein showcase the potential value of these conjugates as therapeutics against oxidative-stress-mediated cellular damage specific to noise-induced hearing loss.

Published
2024
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18. Hyaluronic acid-ibuprofen conjugation: a novel ototherapeutic approach protecting inner ear cells from inflammation-mediated damage

Author

Bhaskar Birru, Joachim G. S. Veit, Elizabeth M. Arrigali, Jack Van Tine, Emma Barrett-Catton, Zachary Tonnerre, Philippe Diaz, and Monica A. Serban

Subjects
inflammation, hyaluronic acid, ibuprofen, cochlea, ototherapeutic, Therapeutics. Pharmacology, RM1-950
Abstract

There is a substantial need of effective drugs for the treatment of hearing loss, which affects nearly 500 million individuals globally. Hearing loss can be the result of intense or prolonged noise exposure, ototoxic drugs, infections, and trauma, which trigger inflammatory signaling cascades that lead to irreversible damage to cochlear structures. To address this, we developed and characterized a series of covalent conjugates of anti-inflammatory drugs to hyaluronic acid (HA), for potential use as topical ototherapeutics. These conjugates were tested in in vitro assays designed to mirror physiological processes typically observed with acoustic trauma. Intense noise exposure leads to macrophage recruitment to the cochlea and subsequent inflammatory damage to sensory cells. We therefore first tested our conjugates’ ability to reduce the release of inflammatory cytokines in macrophages. This anti-inflammatory effect on macrophages also translated to increased cochlear cell viability. In our initial screening, one conjugate, ibuprofen-HA, demonstrated significantly higher anti-inflammatory potential than its counterparts. Subsequent cytokine release profiling of ibuprofen-HA further confirmed its ability to reduce a wider range of inflammatory markers, to a greater extent than its equivalent unconjugated drug. The conjugate’s potential as a topical therapeutic was then assessed in previously developed tympanic and round window membrane tissue permeation models. As expected, our data indicate that the conjugate has limited tympanic membrane model permeability; however, it readily permeated the round window membrane model and to a greater extent than the unconjugated drug. Interestingly, our data also revealed that ibuprofen-HA was well tolerated in cellular and tissue cytocompatibility assays, whereas the unconjugated drug displayed significant cytotoxicity at equivalent concentrations. Moreover, our data highlighted the importance of chemical conjugation of ibuprofen to HA; the conjugate had improved anti-inflammatory effects, significantly reduced cytotoxicity, and is more suitable for therapeutic formulation. Overall, this work suggests that ibuprofen-HA could be a promising safe and effective topical ototherapeutic for inflammation-mediated cochlear damage.

Published
2024
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19. Evaluation of 6 Commercial SARS-CoV-2 Serology Assays Detecting Different Antibodies for Clinical Testing and Serosurveillance.

Author

Nicholson, Suellen, Karapanagiotidis, Theo, Khvorov, Arseniy, Douros, Celia, Mordant, Francesca, Bond, Katherine, Druce, Julian, Williamson, Deborah, Purcell, Damian, Lewin, Sharon, Sullivan, Sheena, Subbarao, Kanta, and Catton, Mike

Subjects
ELISA, SARS-CoV-2 antibodies, humoral immune response, neutralization test, serology
Abstract

BACKGROUND: Serological testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) complements nucleic acid tests for patient diagnosis and enables monitoring of population susceptibility to inform the coronavirus disease 2019 (COVID-19) pandemic response. It is important to understand the reliability of assays with different antigen or antibody targets to detect humoral immunity after SARS-CoV-2 infection and to understand how antibody (Ab) binding assays compare to those detecting neutralizing antibody (nAb), particularly as we move into the era of vaccines. METHODS: We evaluated the performance of 6 commercially available enzyme-linked immunosorbent assays (ELISAs), including a surrogate virus neutralization test (sVNT), for detection of SARS-CoV-2 immunoglobulins (IgA, IgM, IgG), total or nAb. A result subset was compared with a cell culture-based microneutralization (MN) assay. We tested sera from patients with prior reverse transcription polymerase chain reaction-confirmed SARS-CoV-2 infection, prepandemic sera, and potential cross-reactive sera from patients with other non-COVID-19 acute infections. RESULTS: For sera collected >14 days post-symptom onset, the assay achieving the highest sensitivity was the Wantai total Ab at 100% (95% CI, 94.6%-100%), followed by 93.1% for Euroimmun NCP-IgG, 93.1% for GenScript sVNT, 90.3% for Euroimmun S1-IgG, 88.9% for Euroimmun S1-IgA, and 83.3% for Wantai IgM. Specificity for the best-performing assay was 99.5% for the Wantai total Ab, and for the lowest-performing assay it was 97.1% for sVNT (as per the Instructions for Use [IFU]). The Wantai Total Ab had the best agreement with MN at 98% followed by Euroimmun S1-IgA, Euro NCP-IgG, and sVNT (as per IFU) with 97%, 97% and 95%, respectively; Wantai IgM had the poorest agreement at 93%. CONCLUSIONS: Performance characteristics of the SARS-CoV-2 serology assays detecting different antibody types are consistent with those found in previously published reports. Evaluation of the surrogate virus neutralization test in comparison to the Ab binding assays and a cell culture-based neutralization assay showed good result correlation between all assays. However, correlation between the cell-based neutralization test and some assays detecting Abs not specifically involved in neutralization was higher than with the sVNT. This study demonstrates the reliability of different assays to detect the humoral immune response following SARS-CoV-2 infection, which can be used to optimize serological test algorithms for assessing antibody responses post-SARS-CoV-2 infection or vaccination.

Published
2021

20. Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis

Author

Erin A. Catton, Daniel A. Bonsor, Carolina Herrera, Margaretha Stålhammar-Carlemalm, Mykola Lyndin, Claire E. Turner, Jo Soden, Jos A. G. van Strijp, Bernhard B. Singer, Nina M. van Sorge, Gunnar Lindahl, and Alex J. McCarthy

Subjects
Science
Abstract

Abstract Life-threatening bacterial infections in women after childbirth, known as puerperal sepsis, resulted in classical epidemics and remain a global health problem. While outbreaks of puerperal sepsis have been ascribed to Streptococcus pyogenes, little is known about disease mechanisms. Here, we show that the bacterial R28 protein, which is epidemiologically associated with outbreaks of puerperal sepsis, specifically targets the human receptor CEACAM1. This interaction triggers events that would favor the development of puerperal sepsis, including adhesion to cervical cells, suppression of epithelial wound repair and subversion of innate immune responses. High-resolution structural analysis showed that an R28 domain with IgI3-like fold binds to the N-terminal domain of CEACAM1. Together, these findings demonstrate that a single adhesin-receptor interaction can drive the pathogenesis of bacterial sepsis and provide molecular insights into the pathogenesis of one of the most important infectious diseases in medical history.

Published
2023
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21. Symptoms and laboratory manifestations of mild COVID-19 in a repatriated cruise ship cohort.

Author

Bailie, C, Franklin, L, Nicholson, S, Mordant, F, Alpren, C, Stewart, T, Barnes, C, Fox, A, Druce, J, Subbarao, K, Catton, M, van Diemen, A, and Sullivan, S

Subjects
Asymptomatic, COVID-19, SARS-CoV-2, cruise ship, serology, Adult, Aged, Aged, 80 and over, Antibodies, Viral, COVID-19, Cohort Studies, Enzyme-Linked Immunosorbent Assay, Female, Humans, Incidence, Male, Middle Aged, Neutralization Tests, SARS-CoV-2, Ships, Symptom Assessment, Tourism, Uruguay, Victoria, Virus Shedding
Abstract

Much of our current understanding about novel coronavirus disease 2019 (COVID-19) comes from hospitalised patients. However, the spectrum of mild and subclinical disease has implications for population-level screening and control. Forty-nine participants were recruited from a group of 99 adults repatriated from a cruise ship with a high incidence of COVID-19. Respiratory and rectal swabs were tested by polymerase chain reaction (PCR) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Sera were tested for anti-SARS-CoV-2 antibodies by enzyme-linked immunosorbent assay (ELISA) and microneutralisation assay. Symptoms, viral shedding and antibody response were examined. Forty-five participants (92%) were considered cases based on either positive PCR or positive ELISA for immunoglobulin G. Forty-two percent of cases were asymptomatic. Only 15% of symptomatic cases reported fever. Serial respiratory and rectal swabs were positive for 10% and 5% of participants respectively about 3 weeks after median symptom onset. Cycle threshold values were high (range 31-45). Attempts to isolate live virus were unsuccessful. The presence of symptoms was not associated with demographics, comorbidities or antibody response. In closed settings, incidence of COVID-19 could be almost double that suggested by symptom-based screening. Serology may be useful in diagnosis of mild disease and in aiding public health investigations.

Published
2021

22. Ultrasound-assisted neuraxial anaesthesia and intra-operative non-invasive ventilation for emergency caesarean section in a parturient with profound respiratory failure: A case report

Author

Tim Catton, Richard Isaacs, and Luke Bracegirdle

Subjects
combined spinal-epidural, non-invasive ventilation, obstetric anaesthesia, respiratory failure, ultrasound-assisted neuraxial anaesthesia, Anesthesiology, RD78.3-87.3, Gynecology and obstetrics, RG1-991
Abstract

Here we describe the perioperative management of a patient with profound respiratory failure. A 32-year-old parturient presented with acute-on-chronic respiratory failure at 30 weeks' gestation. Her deterioration was attributed to advancing gestation on a background of significant respiratory comorbidity and required emergency caesarean section. Anaesthesia for a safe operative delivery was predicted to be difficult, carrying significant risk for both patient and fetus. We describe the successful use of intra-operative non-invasive ventilation and ultrasound-assisted neuraxial anaesthesia in order to facilitate emergency caesarean section without general anaesthesia.

Published
2024
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23. Clinico-demographic characteristics and outcomes of radiation-induced sarcomas (RIS): a CanSaRCC study

Author

Mauricio Fernando Ribeiro, Hagit Peretz Soroka, Zainab Bhura, Ian Hirsch, Jay Wunder, Peter Ferguson, Kim Tsoi, Savtaj Brar, Rebecca Gladdy, Carol Swallow, Peter Chung, Charles Catton, Philip Wong, Geoffrey Watson, Albiruni Ryan Abdul Razak, Abha A. Gupta, and David Shultz

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background: Radiation-induced sarcomas (RIS) tend to have aggressive behaviour and because of their rarity, the most appropriate management for these malignancies is uncertain. Objectives: Using the Canadian Sarcoma Research and Clinical Collaboration (CanSaRCC) database, a national sarcoma registry, we aimed to investigate prognostic factors and outcomes for RIS. Design: Retrospective study of RIS patients treated from 1996 to 2021 at three Canadian centres. Methods: RIS was defined as a sarcoma arising in a previously irradiated field following a 3+ year latency period, whose histology was distinct from the initially irradiated tumour. Clinicopathologic and treatment-related information was extracted from the CanSaRCC database. Overall survival (OS) was defined as the time from RIS diagnosis to death from any cause. Response rate (RR) to neoadjuvant chemotherapy (NACT) was based on physician assessment. Time-to-event analyses were estimated using the Kaplan–Meier method, with Cox regression for multivariate analysis. We considered a two-tailed p -value of

Published
2023
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24. Practice-based training strategy for therapist-driven prostate MR-Linac adaptive radiotherapy

Author

Winnie Li, Jerusha Padayachee, Inmaculada Navarro, Jeff Winter, Jennifer Dang, Srinivas Raman, Vickie Kong, Alejandro Berlin, Charles Catton, Rachel Glicksman, Victor Malkov, Andrew McPartlin, Kaushik Kataki, Patricia Lindsay, and Peter Chung

Subjects
Therapist-driven workflow, MR-Linac, Adaptive radiation therapy, Prostate, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Purpose: To develop a practice-based training strategy to transition from radiation oncologist to therapist-driven prostate MR-Linac adaptive radiotherapy. Methods and materials: In phase 1, 7 therapists independently contoured the prostate and organs-at-risk on T2-weighted MR images from 11 previously treated MR-Linac prostate patients. Contours were evaluated quantitatively (i.e. Dice similarity coefficient [DSC] calculated against oncologist generated online contours) and qualitatively (i.e. oncologist using a 5-point Likert scale; a score ≥ 4 was deemed a pass, a 90% pass rate was required to proceed to the next phase). Phase 2 consisted of supervised online workflow with therapists required no intervention from the oncologist on 10 total cases to advance. Phase 3 involved unsupervised therapist-driven workflow, with offline support from oncologists prior to the next fraction. Results: In phase 1, the mean DSC was 0.92 (range 0.85–0.97), and mean Likert score was 3.7 for the prostate. Five therapists did not attain a pass rate (3–5 cases with prostate contour score

Published
2023
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26. The role of chemotherapy and radiotherapy in localized extraskeletal osteosarcoma

Author

Heng, Marilyn, Gupta, Abha, Chung, Peter W, Healey, John H, Vaynrub, Max, Rose, Peter S, Houdek, Matthew T, Lin, Patrick P, Bishop, Andrew J, Hornicek, Francis J, Chen, Yen-Lin, Lozano-Calderon, Santiago, Holt, Ginger E, Han, Ilkyu, Biau, David, Niu, Xiaohui, Bernthal, Nicholas M, Ferguson, Peter C, Wunder, Jay S, Group, Japanese Musculoskeletal Oncology, Ueda, Takafumi, Kakunaga, Shigeki, Kawai, Akira, Sugiura, Hideshi, Kidani, Teruki, Kunisasa, Toshiyuki, Ozaki, Toshifumi, Ae, Keisuke, Nagano, Akihito, Ohno, Takatoshi, Hiraoka, Koji, Yamamoto, Norio, Tsuchiya, Hiroyuki, Matsumoto, Yoshihiro, Yanagawa, Takashi, Nakayama, Robart, Morioka, Hideo, Kubo, Tadahiko, Simose, Shoji, Yamagami, Yoshiki, Yamamoto, Tetsuji, Kawasaki, Motohiro, Torigoe, Tomoaki, Yazawa, Yasuo, Akiyama, Toru, Gokita, Tabu, Manabe, Jun, Kaya, Mitsunori, Emori, Makoto, Nakamura, Tomoki, Matsumine, Akihiko, Sugihara, Shinsuke, Yokouchi, Masahiro, Komiya, Setsuro, Suehara, Yoshiyuki, Takagi, Tatsuya, Kawamoto, Teruya, Wasa, Junji, Yonemoto, Tsukasa, Ishii, Takeshi, Baba, Ichiro, Hoshi, Manabu, Hamada, Kenichiro, Naka, Norifumi, Sotobori, Tsukasa, Araki, Nobuhito, Okuma, Tomotake, Goto, Takahiro, Kobayashi, Hiroshi, Kawano, Hirotaka, Hosaka, Masami, Futani, Hiroyuki, Hiraga, Hiroaski, Nishida, Yoshihiro, Collaborative, Soft Tissue Osteosarcoma International, Griffin, Anthony, Razak, Albiruni R Abdul, Shultz, David Benjamin, Catton, Charles, Robinson, Steven, Patel, Shreyaskumar R, Lewis, Valerae O, Guadagnolo, B Ashleigh, DeLaney, Thomas, Wang, Haotong, Raskin, Kevin, Callan, Alexandra K, Henshaw, Robert, Isler, Marc, Mottard, Sophie, Chen, Wei-Ming, Traub, Frank, Chen, Tom Wei-Wu, Turcotte, Robert E, Davidson, Darin, Tunn, Per-Ulf, Loong, Herbert, Ghert, Michelle, Werier, Joel, and Clarkson, Paul

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Patient Safety, Clinical Research, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Osteosarcoma, Prognosis, Retrospective Studies, Risk Factors, Survival Analysis, Young Adult, Extraskeletal osteosarcoma, Soft-tissue osteosarcoma, Chemotherapy, Radiotherapy, Radiation therapy, Japanese Musculoskeletal Oncology Group, Soft Tissue Osteosarcoma International Collaborative, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

PurposeThe role of chemotherapy (CT) and radiotherapy (RT) for management of extraskeletal osteosarcoma (ESOS) remains controversial. We examined disease outcomes for ESOS patients and investigated the association between CT/RT with recurrence and survival.Patients and methodsRetrospective review at 25 international sarcoma centers identified patients ≥18 years old treated for ESOS from 1971 to 2016. Patient/tumour characteristics, treatment, local/systemic recurrence, and survival data were collected. Kaplan-Meier survival and Cox proportional-hazards regression and cumulative incidence competing risks analysis were performed.Results370 patients with localized ESOS treated definitively with surgery presented with mainly deep tumours (n = 294, 80%). 122 patients underwent surgical resection alone, 96 (26%) also received CT, 70 (19%) RT and 82 (22%) both adjuvants. Five-year survival for patients with localized ESOS was 56% (95% CI 51%-62%). Almost half of patients (n = 173, 47%) developed recurrence: local 9% (35/370), distant 28% (102/370) or both 10% (36/370). Considering death as a competing event, there was no significant difference in cumulative incidence of local or systemic recurrence between patients who received CT, RT, both or neither (local p = 0.50, systemic p = 0.69). Multiple regression Cox analysis showed a significant association between RT and decreased local recurrence (HR 0.46 [95% CI 0.26-0.80], p = 0.01).ConclusionAlthough the use of RT significantly decreased local recurrences, CT did not decrease the risk of systemic recurrence, and neither CT, nor RT nor both were associated with improved survival in patients with localized ESOS. Our results do not support the use of CT; however, adjuvant RT demonstrates benefit in patients with locally resectable ESOS.

Published
2020

27. Management of Locally Recurrent Retroperitoneal Sarcoma in the Adult: An Updated Consensus Approach from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group

Author

Tseng, William W., Swallow, Carol J., Strauss, Dirk C., Bonvalot, Sylvie, Rutkowski, Piotr, Ford, Samuel J., Gonzalez, Ricardo J., Gladdy, Rebecca A., Gyorki, David E., Fairweather, Mark, Lee, Kyo Won, Albertsmeier, Markus, van Houdt, Winan J., Fau, Magalie, Nessim, Carolyn, Grignani, Giovanni, Cardona, Kenneth, Quagliuolo, Vittorio, Grignol, Valerie, Farma, Jeffrey M., Pennacchioli, Elisabetta, Fiore, Marco, Hayes, Andrew, Tzanis, Dimitri, Skoczylas, Jacek, Almond, Max L., Mullinax, John E., Johnston, Wendy, Snow, Hayden, Haas, Rick L., Callegaro, Dario, Smith, Myles J., Bouhadiba, Toufik, Desai, Anant, Voss, Rachel, Sanfilippo, Roberta, Jones, Robin L., Baldini, Elizabeth H., Wagner, Andrew J., Catton, Charles N., Stacchiotti, Silvia, Thway, Khin, Roland, Christina L., Raut, Chandrajit P., and Gronchi, Alessandro

Published
2022
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28. Impact of intrafraction changes in delivered dose of the day for prostate cancer patients treated with stereotactic body radiotherapy via MR-Linac

Author

Jennifer Dang, Vickie Kong, Winnie Li, Inmaculada Navarro, Jeff D. Winter, Victor Malkov, Alejandro Berlin, Charles Catton, Jerusha Padayachee, Srinivas Raman, Padraig Warde, and Peter Chung

Subjects
Intra-fraction motion, Adaptive radiotherapy, DDOTD, MR-Linac, Prostate SBRT, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Purpose: The purpose of this study is to evaluate the impact of intrafraction pelvic motion by comparing the adapted plan dose (APD) and the computed delivered dose of the day (DDOTD) for patients with prostate cancer (PCa) treated with SBRT on the MR-Linac. Methods: Twenty patients with PCa treated with MR-guided adaptive SBRT were included. A 9-field IMRT distribution was adapted based on the anatomy of the day to deliver a total prescription dose of 3000 cGy in 5 fractions to the prostate plus a 5 mm isotropic margin. Prostate, bladder, and rectum were re-contoured on the MR-image acquired during treatment delivery (MRBO). DDOTD was computed by propagating the dose from the daily adapted plan generated during treatment onto the MRBO. Results: Target coverage was met for all fractions, however, computed DDOTD was significantly less than the APD (p

Published
2022
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30. A Prospective Phase 2 Trial of Transperineal Ultrasound-Guided Brachytherapy for Locally Recurrent Prostate Cancer After External Beam Radiation Therapy (NRG Oncology/RTOG-0526)

Author

Crook, Juanita M, Zhang, Peixin, Pisansky, Thomas M, Trabulsi, Edouard J, Amin, Mahul B, Bice, William, Morton, Gerard, Pervez, Nadeem, Vigneault, Eric, Catton, Charles, Michalski, Jeff, Roach, Mack, Beyer, David, Jani, Ashesh, Horwitz, Eric, Donavanik, Viroon, and Sandler, Howard

Subjects
Clinical Research, Clinical Trials and Supportive Activities, Prostate Cancer, Urologic Diseases, Cancer, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Aged, Biopsy, Brachytherapy, Gastrointestinal Tract, Humans, Male, Middle Aged, Multivariate Analysis, Neoplasm Grading, Neoplasm Recurrence, Local, Prospective Studies, Prostate, Prostate-Specific Antigen, Prostatic Neoplasms, Radiotherapy Dosage, Radiotherapy, Image-Guided, Salvage Therapy, Treatment Outcome, Ultrasonography, Other Physical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeOnly retrospective data are available for low-dose-rate (LDR) salvage prostate brachytherapy for local recurrence after external beam radiation therapy (EBRT). The primary objective of this prospective phase 2 trial (NCT00450411) was to evaluate late gastrointestinal and genitourinary adverse events (AEs) after salvage LDR brachytherapy.Methods and materialsEligible patients had low- or intermediate-risk prostate cancer before EBRT and biopsy-proven recurrence >30 months after EBRT, with prostate-specific antigen levels

Published
2019

31. Web-Based Peer Navigation for Men with Prostate Cancer and Their Family Caregivers: A Pilot Feasibility Study

Author

Jacqueline L. Bender, Parminder K. Flora, Shimae Soheilipour, Mihaela Dirlea, Nandini Maharaj, Lisa Parvin, Andrew Matthew, Charles Catton, Leah Jamnicky, Philip Pollock, Winkle Kwan, Antonio Finelli, and Arminée Kazanjian

Subjects
peer navigation, prostate cancer, digital health, family caregivers, supportive care, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

This study assessed the feasibility, acceptability and potential effects of True North Peer Navigation (PN)—a web-based peer navigation program for men with prostate cancer (PC) and their family caregivers. A one-arm, pre-post pilot feasibility study was conducted at two cancer centres in Canada. Participants were matched through a web-app with a specially trained peer navigator who assessed needs and barriers to care, provided support and encouraged a proactive approach to health for 3 months. Descriptive statistics were calculated, along with paired t-tests. True North PN was feasible, with 57.9% (84/145) recruitment, 84.5% (71/84) pre-questionnaire, 77.5% (55/71) app registration, 92.7% (51/55) match and 66.7% (34/51) post-questionnaire completion rates. Mean satisfaction with Peer Navigators was 8.4/10 (SD 2.15), mean program satisfaction was 6.8/10 (SD 2.9) and mean app usability was 60/100 (SD 14.8). At 3 months, mean ± SE patient/caregiver activation had improved by 11.5 ± 3.4 points (p = 0.002), patient quality of life by 1.1 ± 0.2 points (p < 0.0001), informational support by 0.4 ± 0.17 points (p = 0.03), practical support by 0.5 ± 0.25 points (p = 0.04) and less need for support related to fear of recurrence among patients by 0.4 ± 19 points (p = 0.03). The True North web-based peer navigation program is highly feasible and acceptable among PC patients and caregivers, and the associated improvements in patient and caregiver activation are promising. A randomized controlled trial is warranted to determine effectiveness.

Published
2022
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33. Dosimetric comparison of MR-guided adaptive IMRT versus 3DOF-VMAT for prostate stereotactic radiotherapy

Author

Vickie C. Kong, Jennifer Dang, Winnie Li, Inmaculada Navarro, Jerusha Padayachee, Victor Malkov, Jeff Winter, Srinivas Raman, Alejandro Berlin, Charles Catton, Padraig Warde, and Peter Chung

Subjects
MR-guided adaptive radiotherapy, IMRT, VMAT, Prostate SBRT, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Introduction: To compare the dosimetry of prostate stereotactic radiotherapy (SBRT) delivered by adaptive intensity modulated radiotherapy (A-IMRT) and 3 degree of freedom volumetric modulated arc therapy (3DOF-VMAT). Methods & Materials: Twenty-five prostate patients treated with High Dose Rate (HDR) brachytherapy followed by SBRT were included (fifteen with hydrogel spacer in place for treatment). Interfraction changes in the volume of prostate, rectum and bladder were measured. Fractional dose to these structures was estimated for A-IMRT and 3DOF-VMAT for comparison against the corresponding reference dose and between each other. Results: Clinically acceptable dose was delivered to prostate in all 125 fractions through A-IMRT and 3DOF-VMAT. A-IMRT was better than 3DOF-VMAT in reducing dose to 1 cm3 of rectum. Conversely, 3DOF-VMAT was superior in sparing 50% and 20% of rectum. When comparing the reference and delivered dose, there was no significant difference for Bladder D5cm3 for either technique. However, rectum in the high dose region benefited more from A-IMRT by being irradiated to a lower than reference dose in more fractions than 3DOF-VMAT. Hydrogel spacer reduced the rectal dose and was associated with a smaller deviation from reference dose for rectum D50% for A-IMRT. Conclusions: Despite the presence of large interfraction organ volumes changes, clinically acceptable dose was delivered to the prostate by both systems. A-IMRT facilitated a greater rectal sparing from the high dose region than 3DOF-VMAT. Further reduction in rectal dose could be achieved by hydrogel spacer to displace the rectum, or by adaptation delivered by VMAT.

Published
2022
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35. Impact of psoriatic disease on women aged 18 to 45: Results from a multinational survey across 11 European countries

Author

Sandy R. McBride, MBBS, FRCP, MD, Maria C. Fargnoli, MD, Anne-Claire Fougerousse, MD, Marta García Bustínduy, MD, PhD, Louise Catton, BSc, Lerzan Senturk, MD, Cécile Ecoffet, PharmD, Jan Koren, Laura Andreoli, MD, PhD, Laura C. Coates, MBChB, MRCP, PhD, and Alice Titialii, MSc

Subjects
Psoriasis, psoriatic arthritis, women of childbearing age, family planning, mental health, Dermatology, RL1-803
Abstract

ABSTRACT: Background: Plaque psoriasis (PSO) is a long-term inflammatory condition that can cause concomitant joint symptoms (psoriatic arthritis [PsA]) in up to 30% of patients. The impact of psoriatic disease on disease outcomes and quality of life is greater in women than men. Objective: We evaluated the impact of psoriatic disease on women aged 18 to 45 years across Europe. Methods: Women aged 18 to 45 years with moderate to severe PSO, PsA, or PSO + PsA (PSO with progression to PsA) and prior biologic experience were recruited from market research panels and patient association groups of the International Federation of Psoriasis Associations, European Federation of Psoriasis Patient Associations, and Arthritis Ireland and asked to complete a survey. Questions covered social and psychological wellbeing, employment, and family planning. Question types included 5- or 7-point agreement scales, where the highest/lowest two ratings were considered agreement/disagreement, respectively. The results are reported as proportions of those who selected the answer, divided by overall respondents for each question. Women were not required to answer all questions. Results: Survey respondents (N = 573) had a diagnosis of PSO (n = 236), PsA (n = 173), or PSO + PsA (n = 164). Women self-reported similar mean scores for physical (57.0 of 100) and mental (59.0 of 100) health. A fifth (21%) had not achieved their desired career due to PSO/PsA; career dissatisfaction and increased sick leave were linked to poor mental health. Some women reported having a limited social life (33%), smaller families (34%), and being more likely to adopt children (27%) due to PSO/PsA. A quarter of women (27%) reported not understanding enough about PSO/PsA (nonmembers vs. members of patient association groups: 37% vs. 8%). Conclusion: Our findings highlight the considerable burden of psoriatic disease on women of childbearing age. Increased provision of information tailored to women, training for health care professionals, and shared decision-making between patients and health care professionals may help better support women with psoriatic disease.

Published
2021
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36. Lymphocytic Choriomeningitis Virus Infection, Australia

Author

Leon Caly, Ashleigh F. Porter, Joanna Chua, James P. Collet, Julian D. Druce, Michael G. Catton, and Sebastian Duchene

Subjects
lymphocytic choriomeningitis virus, genome sequencing, Australia, viruses, zoonoses, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

During a mouse plague in early 2021, a farmer from New South Wales, Australia, sought treatment for aseptic meningitis and was subsequently diagnosed with locally acquired lymphocytic choriomeningitis virus infection. Whole-genome sequencing identified a divergent and geographically distinct lymphocytic choriomeningitis virus strain compared with other published sequences.

Published
2022
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37. Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial

Author

Parker, Chris C, Clarke, Noel W, Cook, Adrian D, Kynaston, Howard, Catton, Charles N, Cross, William R, Petersen, Peter M, Persad, Rajendra A, Saad, Fred, Bower, Lorna C, Logue, John, Payne, Heather, Forcat, Silvia, Goldstein, Cindy, Murphy, Claire, Anderson, Juliette, Barkati, Maroie, Bottomley, David M, Branagan, Jennifer, Choudhury, Ananya, Chung, Peter W M, Cogley, Lyn, Goh, Chee L, Hoskin, Peter, Khoo, Vincent, Malone, Shawn C, Masters, Lindsey, Morris, Stephen L, Nabid, Abdenour, Ong, Aldrich D, Raman, Rakesh, Tarver, Kathryn L, Tree, Alison C, Worlding, Jane, Wylie, James P, Zarkar, Anjali M, Parulekar, Wendy R, Parmar, Mahesh K B, Sydes, Matthew R, Amos, Claire, Beaney, Katherine, Bellenger, Katharine, Brawley, Chris, Chung, Christina, Cook, Adrian, Embleton, Andrew, Forcat, Silvia, Goldstein, Cindy, Grabey, Jenna, Hague, Dominic, Herasimtschuk, Anna, Islam, Zaheer, Jovic, Gordana, Maniatis, Christos, Masters, Lindsey, Mohamed, Fatima, Morgan, Rachel, Murphy, Claire, Noor, Dipa, Parmar, Max, Patterson, Paul, Pickering, Holly, Pugh, Cheryl, Rauchenberger, Mary, Ribeiro, Helena, Roach, Carol, Seray-Wurie, Fatimah, Shaji, Preetha, Sims, Hannah, Spittle, Ben, Sydes, Matthew, Tappenden, Nancy, Tsang, Lilian, Uscinska, Barbara, Brown, Teddy, Casey, Sue, Davidson, Cathy, Dellar, Conor, Fletcher, Mandy, Meyer, Ralph, Murphy, Karen, Parulekar, Wendy, Richardson, Harriet, Richardson, Karen, Whelan, Kate, Bissett, Donald, Bonner-Shand, Shelagh, Grant, Judith, Lynch, Rory, MacDonald, Graham, McWilliam, Marie, Moir, Rachel, Rodwell, Sue, Shearer, Kirsty, Smith, Margaret, Binns, Louise, Briggs, Maxine, Brown, Simon, Casanova, Nathalie, Clark, Katy, Hartley, Jasmine, Henry, Ann, Henson, Helen, Hill, Pipa, Jeyasanger, Ganesan, McAlister, Judy, Parkinson, Sharron, Shaw, Alison, Alcock, Christopher, Brady, Joanne, Camilleri, Philip, Carpenter, Janice, Hogbin, Emma, Hyde, Katherine, Kavanagh, Roisin, Ngumo, Alice, Padilla-Harris, Cheryl, Panakis, Niki, Pwint, Thinn, Sabharwal, Ami, Stammers, Tracey, Stone, Helena, Varley, Gail, Weaver, Andrew, Wynn, Hazel, Allan, Elaine, Ansari, Jawaher, Cannon, Philip, Carruthers, Ross, Coubrough, Claudia, Cowan, Chloe, Glen, Hilary, Graham, Janet, Hardie, Maryon, Love, Clare, Macleod, Nicholas, Mahmood, Rana, McClements, Jane, McGlynn, Brian, McKernan, Margaret, Mcleod, Nick, Othman, Aqilah, Ross, Kristy, Roxburgh, Patricia, Templeton, Maureen, Tufail, Aisha, Turley, Claudia, Wilson, Mark, Ali, Zulfiqer, Andrews, Kelly, Burns, Rebecca, Butterworth, Caryl, Coventry, Thomas, Evans, Angela, Jones, Gareth, Lewis, Sion, Oommen, Nikhil, Owen, Susan, Saxton, Wendy, Tapping, Sister Hayley, Thomas, Dianne, Thomas, Rachel, Walker, Beth, Williams, Rachel, Collard, Susan, Ford, Victoria, Goodhind, Frances, Holbrook, Becky, Kershaw, Elizabeth, Ley, Samantha, Martinez, Maria, McCormack, Anne, Sheehan, Denise, Toy, Elizabeth, Van-Koutrik, Lynne, Varughese, Mohini, Aitken, Katherine, Barlow, David, Beattie, Louise, Bownie-Mukumbu, Godfrey, Bryan, Rachel, Corner, Victoria, Edwards, Abigail, Fazekasne Fulep, Adrienn, Guerrero-Urbano, Teresa, Gwilt, Julie, Happle, Liz, Jackman, Dee, Krysta, Beata, Paisey, Sangeeta, Shaffer, Richard, Smith, Jackie, Westley, Rosalyne, Yusof, Hilawati, Appleby, Rowan, Avis, Joanne, Beresford, Mark, Brydon-Hill, Ruth, Cox, Christine, Curtis, Samantha, Elwell, Christine, Frim, Olivera, Hamilton, Beatrice, Hudson, Zoe, Jenner, Abigail, Mantle, Mark, Mason, Jessica, Masson, Susan, McFarlane, Jonathan, Newman, Hugh, Pocock, Abigail, Robertson, Bryony, Tomlinson, Eve, Wassall, Rebecca, Williams (Née Allen), Sister Tania, Brown, Grace, Clarke, Peter, Cole, Aiden, Cousins, Jane, Gilchrist, Gail, Hagan, Chris, Hanna, Emma, Harney, Jackie, Hetherington, Stacey, Houghton, Fionnuala, Hynds, Sharon, Jain, Suneil, Johnston, Ruth, Keane, Patrick, Lyons, Ciara, McAleese, Jonathan, McAllister, Jo, McKenna, Karen, Mitchell, Darren, Murray, Stacey, O'Sullivan, Joe, Rajan, Nambi, Shum, Poh Lin, Stewart, David, Stranex, Stephen, Totten, Grace, Chandrashekara, Madhura, Drew, Ellen, Drew, Mary (Ellen), Fletcher, Julie, Gamble, Tina, Lokes, Rachel, Schumacher, Ann, Shetty, Kavitha, Sohanpal, Sundip, Whitehouse, James, Zarkar, Anjali, Ford, Daniel, Glaholm, John, Lenton, Daniel, O'Beney, Rachael, Sohanpal, Sundip, Taylor, Helen, Thomas, Helen, Whitehouse, James, Chetiyawardana, Samantha, Doherty, A, El-Modir, Ahmed, Ford, Daniel, Glaholm, John, Gunn, Melanie, James, Nicholas, Kedge, Liz, Lokes, Rachel, Mannan, Aliyah, Marange, Josephine, Morrison, Andrew, Okubanjo, Maryanne, Olaniyi-Oduntan, Darlletta, Peterkin, Zhane, Preece, George, Qureshi, Zayn, Ross, Liliam, Samra, Tarandip, Southgate, Elizabeth, Stephens, Rebekah, Stevenson, Robert, Watson-Jones, Phillip, Zarkar, Anjali, Abdulwahid, Danya, Ainsworth, Sarah, Ashworth, Sue, Beard, Karen, Charnley, Natalie, Desai, Parth, Fielding, Bethany, Flaherty, Jan, Forrest, Diane, Frankland, Helen, Haidar, Imran, Hargreaves, Jeanette, Henry, Joanne, Hugill, Angela, Jewers, Karen, Keith, Sarah, Kilroy, Stephen, King, Jennifer, Parikh, Omi, Riley, Karen, Ryan-Smith, Janet, Thomas, Jacqueline, Thompson, Catherine, Tickle, Vivienne, Waring, Lynsey, Wise, Marcus, Abdulwahid, Danya, Ainsworth, Sarah, Ashworth, Sue, Beard, Karen, Dawson, Louise, Desai, Parth, Ditchfield, Julie, Fielding, Bethany, Flaherty, Jan, Forrest, Diane, Frankland, Helen, Haidar, Imran, Hargreaves, Jeanette, Henry, Joanne, Hugill, Angela, Jewers, Karen, Keith, Sarah, Kilroy, Stephen, King, Jennifer, Parikh, Omi, Riley, Karen, Ryan-Smith, Janet, Thompson, Catherine, Tickle, Vivienne, Waring, Lynsey, Wise, Marcus, Al-Samarraie, Amir, Ali, Zulfiqer, Bolger, Annette, Davies, Llinos, Flavin, Aileen, Heron, Jane, Hughes, Faye, Jackson, Kim, Lewis, Joanne, Manley, Rachel, Oommen, Nikhil, Rutter, Charley-Anne, Smith, Nick, Srinivasan, Vaiku, Stockport, Jane, Tapping, Sister Hayley, Thomas, Heather, Toussi, H, Wood, Cathryn, Archer, Simon, Fletcher, Joanne, Ginnelly, Helen, Kirkby, Amy, Knight (n. Sherburn), Victoria, Lawrence nee Palmer, Tara, Mashegede, Beverley, Metcalf, Karen, Panades, Miguel, Sreenivasan, Thiagarajan, Szymiczek, Kinga, Thomas, Isobel, Young, Anita, Broadley, Eve, Brock, Sue, Davies, Joseph, Jones, Stephanie, McCully, Ruby, Naraine, Nicky, Preece, Kate, Purandare, Laura, Rabbi, Taslima, Savage, Sarah, Vamplew, Luke, Bamford, Linda, Benton, Richard, Cotterill, Lauren, Henry, Ann, Inman, Hayley, Karsera, Louise, Kay, Anne Marie, Kenyon, Lucille, Lazarte, Jannika, McNulty, Dawn, Moore, Eleanor, Nallathambi, Chandran, Naylor, Deirdre, Owen, Lisa, Parikh, Shefali, Pendrill, Amy, Price, Joanne, Robertshaw, Helen, Rodda, Sree, Sewell, Jane, Teo, Mark, Waldron, Eleanor, Bloomfield, David, Blythe, Tracy, Brown, Joanne, Carr, Philippa, Chambers, Carla, Dlodlo, Jessica, Frattaroli, Paul, Gilbert, Duncan, Hart, Andrew, Hodges, Samantha, Hooper, Simon, Hunter, Catherine, Lactao, Ranee, Leitao, Madalena, McKinna, Fiona, Nikapota, Ashok, Peterson, Jane, Robinson, Angus, Tremlett, Jean, Webb, Andrew, Wilkins, Marie, Young, Bobbie, Bahl, Amit, Baxter, Matt, Beresford, Mark, Bowers, Dawn, Challipalli, Amarnath, Coe, Marc, Cowley, Sue, Gillatt, David, Griffiths, Dorothy, Henson (nee Savidge), Verity, Hilman, Serena, Hollister, Robert, Kisanga, Mary, Lee, Vivienne, Lowe, Amelia, Macefield, Rhiannon, Masson, Susan, Pegler, Ruth, Robertson, Peter, Saldanha, Helen, Simmonds, Mary, Sims, Laura, Wheeler, Lucie, Wilson, Paula, Woods, Martin, Yarrow, Sue, Zelley, Sarah, Abd Alazeez, Mohamed, Alderton, Kate, Bahl, Amit, Beresford, Mark, Brain, Carol, Challipalli, Amarnath, Chilcott, Helen, Clarke, Samantha, Cobos-Arrivabene, Marta, Corderoy, Helen, Cousins, Rebecca, Garner, Victoria, Gillatt, David, Herbert, Chris, Johnson, Lyndsey, Jones, Kathryn, Kemp, Gail, Kirkby, Sarah, Kirkpatrick, Suriya, Koupparis, Anthony, Manning, Courtney, Oxley, Jon, Perry, Emily, Persad, Raj, Phipps, Charlotte, Richmond-Russell, Kerry, Rowe, Edward, Shelton, Luke, Shiridzinomwa, Constance, Smith, Carolyn, Treasure, Ann, Wilson, Paula, Wyatt, Clare, Beesley, Katherine, Benson, Richard, Couch, Ellie, Foxwell, Sue, Goss, Vanessa, Harnwell, Juliette, Hughes-Davies, Luke, Joslin, Vicky, Laubscher, Angelique, Mazhar, Danish, Patterson, Helen, Raj, Sanjay, Ramanujachar, Ramya, Rimmer, Yvonne, Robinson, Nicola, Russell, Simon, Stone, Matthew, Thomas, Robert, Treeby, Jo, Vickery, Kathryn, Woodward, Cathryn, Ahmed, Ilyas, Appleby, Bonny, Brulinski, Patryk, Buckley, Julie, Catt, Natalie, Coppins, Helen, Crawford, Sister Denise, Davies, Julie-Ann, Drakeley, Susan, Edwards, Albert, Evans, Clary, Galante, Joao, Gladwell, Louise, Gough, Jessica, Hargreaves, Carolyn, Hegarty, Gemma, Kehoe, Laura, Larkins, Rachel, Lipsham, Margaret, Little, Jessica, Malde, Rohit, Middleton, Sharon, Mikropoulos, Christos, Mirza, Arafat, Mithal, Natasha, Nathan, Kannon, Raman, Rakesh, Rendall, Alice, Robinson, Karen, Ryan, Rachel, Sim, Van, Swann, Michelle, Tasker, Lorraine, Taylor, Katy, Thomas, Carys, Trigonis, Ioannis, Walker, Karen, Williams, Joanne, Williamson, Elizabeth, Wood, Marian, Wood, Pauline, Zurakovsky, Hilary, Bois (nee Harris), Elizabeth, Chan, Hin Fan, Chikopela, Loveness, Clark, Helen, Clements, Colette, Holliday, Samantha, Hughes, Owen, Jones, Clare, Kynaston, Howard, Mason, Malcolm, Narahari, Krishna, Pearse, Kevin, Staffurth, John, Austin, Mandy, Barnett, Christian, Camburn, Sister Tracey, Dawson, Elizabeth, Gibson, Sian, Hamid, Abdel, Kancherla, Kiran, Leone, Priscilla, Perkins, Lauren, Ramsay, Valerie, Singizi, Bryan, Allen, Julie, Anderson, Susan, Andrews (nee Moore), Eleanor, Bakawala, Rehana, Beazer, Sarah, Binks, Colin, Bowen, Jo, Broomfield, Barbara, Cook, Audrey, Crossley, Lin, Ford, Chris, Forkes, Janet, Hall, Julia, Healey-Mariano, Jennifer, Jenkins, Peter, Johnson, Nigel, Jonnada, Sai, Owen, Roger, Pratten, Elaine, Sayers, Rachel, Shimell, Chris, Skelton, Amy, Tan, Matthew, Trigg-Hogarth, Kate, Wronski, Sue, Aldous, Mary, Archer, Denise, Eccleson, Helen, Gallimore, Elizabeth, Green, Sue, Ibrahim, Azman, Jones, Carys, Prince, Jude, Chrystal, Melanie, Din, Omar, Firth, Alexandra, Ford, Nicky, Kirkbride, Peter, Martindale, John, Redfearn, Alison, Smedley (nee McCabe), Janine, Smith, Lucy, Sorice, Vittoria, Stevenson, Lesley, Toms, Julie, Wood, Sister Kim, Barke, Nyssa, Basu, Devy, Dewar, Lorna, Driscoll, Celine, Hunting, Liz, Kumar, Muthar, Leone, Priscilla, Mabelin, Louies, Sizer, Bruce, Thorogood, Lucy, Askew, Sarah, Beech, Darren, Broom, Jane, Duley, Emma, Firth, Elizabeth, Gould, Aaron, Hocking, Christopher, Johns, Louise, Kent, Emma, Madine, John, Partridge, Kerena, Penhaligon, Corrine, Pentecost, Catherine, Pollard, Kay, Poultney, Melissa, Pynsent, William, Skewes, Johanna, Steele, Anita, Thomson, Alastair H, Topps, Alice, Townley, Luke, Wheatley, Duncan, Brown, Maggie, Chan, Andrew, Connor, Marie, Elwell, Sue, Geraghty, Kerry, Griffiths, Theresa, Hayward, Lesley, Humber, Caroline, Khan, Yakhub, Lake, Sister Judith, Laverick, Rosaleen, Mansell, Gemma, Mislang, Albert, Ngwenya, Su, Panesar, Pritpal, Sanders, Kay, Simmons, Elaine, Sinfield, Melanie, Stanley, Laura, Steventon, Emily, Stockdale, Andrew, Sunny, Manju, Thind, Manreet, Tranter, Fiona, Tsalic, Medy, Worlding, Jane, Adamson, Vanessa, Bennion, Carole, Butler-Barnes, Jenny, Hough, Adele, Hough, Chris, Hughes, Joanne, Irwin, P, Javle, P, Logue, John, Mansfield, Carolyn, Smith, Rachel, Sumner, Lesley, Tomlinson, Annabel, Tran, Anna, Walker, Caroline, Wylie, James, Chakraborti, Prabir, Das, Prantik, Ennis, Dawn, Marriott, Sue, Muthukumar, Dakshinamoorthy, Pattu, Pugazhenthi, Ward, Colin, Alzouebi, Mymoona, Burlace, Barbara, Ferguson, Catherine, Firth, Alexandra, Hooton, Georgia, Jeffcutt, Nicole, Martindale, John, Neal, Amy, Pezaro, Carmel, Sivoglo, Virgil, Smedley (nee McCabe), Janine, Smith, Lucy, Taylor, Jennifer, Wilkinson, Nicola, Wood, Sister Kim, Afzal, Naveed, Anderson, Beverley, Andrews, Stephen, Bakker, Piet, Breakspear, Sally, Cornaby, Andrew, Crellin, Perric, Gibbins, Andrew, Gibbins, Jackie, Glen, Tracy, Goodsell, Josie, Horton, Sarah, Jones, Stephanie, Love, Sally, Masters, Benjamin, Rees, Andrew, Sharpe, Simon, Taylor, Kate, Wignall, Suzy, Harrow, Sister Kath, Jones, Lesley, Kanyi, Karen, Keng-Koh, Pek, McGarry, Karen, Ramachandra, Prakash, Smith, Lucy, Watts, Angela, Baumber, Shelley, Gilbert, Duncan, Howard, Joanna, Jones-Skipper, Kay, Manetta, Caroline, McCrisken, Lauren, McKinna, Fiona, Taylor, Jo-Anne, Williams, Amanda, Clark, Alison, Clarke, Maria, Egan, Lisa, Fiddes, Kathleen, Forman, Susan, Gardiner, Fiona, Jeffrey, David, Mariappan, Param, Mayne, Barbara, McLaren, Duncan, Rogers, Brian, Woods, Catherine, Young, Douglas, Anderson, John, Baines, Kizzy, Crundwell, M, Davey, Elizabeth, Ford, Victoria, Lawless, Theresa, Matkins, Ellen, McGinley, Shannon, McGrath, John, Piper, Jane, Roantree, Alison, Seath, Ingrid, Sheehan, Denise, Srinivasan, Rajaguru, Stott, Mark, Timmings, Katie, Webb, Claire, Al-hasso, Abdulla, Allan, Elaine, Barwell, Lorraine, Cowan, Chloe, Dodds, David, Finnegan, Niall, Griffen, Ailsa, Jones, Rob, Lawless, Claire, MacMillan, Antonia, Mahmood, Rana, Russell, Martin, Sadozye, Azmat, Shirley, Sian, Sidek, Norma, Wallace, Jan, Akhtar, Naeem, Al-hasso, Abdulla, Ansari, Jawaher, Bell, Karen, Humpreys, Louise, McWilliam, Donna, Moody, Emma, O'Neil, Rebecca, Peck, Suzannah, Turley, Claudia, Auladin, Raidah, Bird, Stephanie, Bissa, Caterina, Dabbs, Marianne, Di Maria, Fabio, Goh, Chee, Guerrero-Urbano, Teresa, Harding, Joshua, Jamieson, Ceri, Jones, Jules, Khaksar, Sara, Laing, Robert, Matthews, Laura, Medisetti, Aruna, Molony-Oates, Barbara, Money-Kyrle, Julian, Nobes, Jenny, Rabsztyn, Weronika, Shaffer, Richard, Sidi, Frances, Smale, Daisy May, Stone, Sarah, Tindall, Annie, Woods, Jane, Wu, Min, Daniel, Amelia, Holmes, Evelyn, Kellaway, Joanne, Lewis, Amanda, Light, Teresa, Melcher, Lucinda, Robinson, Lily, Staines, Nikki, Anderson, Susan, Carini, Serrafina, Cook, Audrey, Cooper, Sophie, Evans, Melanie, Follows, Josh, Forkes, Janet, Grant, Warren, Hedges, Andy, Hughes, Claire, Jones (Birch), Janine, King, Lisa, Lees, Laura, Mercer, Lily, Myles, Sophie, Roberts, Zara, Williamson, Nicola, Abbassi, Sara, Alonzi, Roberto, Anyamene, Nicola, Bici, Julia, Collins, Lucy, Dickson, Jeanette, Garrido-Perez, Sandra, Hoskin, Peter, Hughes, Robert, Jenkins, Suzanne, Kowalewska, Paulina, Milner, Jessica, Mitchell, Lesley, Ostler, Peter, Rashid, Aamna, Stapleton, Stephanie, Bashir, Faheem, Bone, Linzi, Clark, Diane, Dixit, Sanjay, Horne, Rhian, Jones, Dawn, Palmer, Sarah, Plowman, Kristian, Rawlings, Julie, Simms, Matthew, Addison, Anglise, Arnott, Seonaid, Borgaonkar, Sudhir, Brown, Sandra, Campbell, Audrey, Colligan, Steve, Cormack, Margaret, Doughty, Victoria, Kelly, Kay, Lister, Debbie, Macdonald, Alison, Macgregor, Carol, Mackay, Rachel, Madeleine, Jude, McNally, Morag, McPhail, Neil, Neville, Sean, Nicholls, Alison, Papakostidi, Aristoula, Simpson, Georgina, Sinclair, Glenda, Skene, Anna, Telfer, Sheena, Urquhart, Zoe, Whillis, David, Etheridge, Charlotte, Ford, Amanda, Ridley, Paul, Scrase, Christopher, Upson, Susan, Venkitaraman, Ramachandran, Capaldi, Lisa, Churn, Mark, Higgins, Linda, Knott, Helen, Stringer (pr. Davis), Sally, Taylor, Jacob, Tranter, Helen, Wollaston, Julie, Brogan (nee Roddie), Stephanie, Erskine, Susan, Hamill, Maureen, Prentice, Lynn, Russell, Martin, Sidek, Norma, Symon, Lesley, Teahan, Seamus, Todd, Anne, Tweedle, James, Young, Sally, Austin (nee Glover), Gemma, Boon, Ian, Bottomley, David, Breckin, Edmund, Clarke, Jude, Coyle, Catherine, Davies, Emily, Goulding, James, Henry, Ann, Kiltie, Anne, Loughrey, Carmel, Moore, Eleanor, Murad, Fatima, Pratt, Claire, Shuttleworth, Pam, Smith, Beccy, Smith, Gill, Branson (née Dineen), Amy, Christmas, Sallyanne, Cooke, Jill, Griffiths, Leyshon, Kent, Christopher, King, Amy, Kockelbergh, Roger, Potterton, Janet, Speed, Lesley, Vasanthan, Subramanian, Walker, Julia, Archer, Simon, Baria, Karin, Bateman, Samantha, Coombs, Sarah, Cunningham, Amy, Dahar, Nazeer, Daruwala, Pallon, Francis, Olesya, Ginnelly, Helen, Hall, Jane, Hoare, Kathryn, Key, Claire, Lockwood, Carol, Mark, Ian, Newton, Rachel, Okubanjo, Maryanne, Panades, Miguel, Sloan, Andrew, Sreenivasan, Thiagarajan, Bermingham, Nicola, Dean, Lynsey, Malik, Zafar, Pilkington, Pauline, Robson, Peter, Rogers, Heather, Rogers, Thomas, Treherne, Katy, Bourke, Amie, Chikkamuniyappa, Bindu, Dalton-Short, Ross, Edwards, Steve, Falconer, Alison, Ford, Amy, Harinarayanan, Sathish, Hassan, Nebah, Hornzee, Gillian, Magwaro, Sophia, McInerney, Sue, Pratap, Bhavesh, Rezkallah, Sarah, Sadare (Olaleye), Ibiyemi, Stancliffe, May, Stewart, Simon, Thoi, Anne-Maree, Westrop, Anna, Ahamadali, Sheefa, Arsanious, Nasr, Balogun, Shaki, Batish, Cheryl, Campbell, Yvonne, Crowley, Claire, Dunne, Emma, Ferreira, Miguel, Haldeos, Anne, Hijab, Adham, Huddart, Robert, John, Babbin, Michaelidou, Andriana, Nawrozzadeh, Mohammed, Pach, Jackie, Patel, Priyanka, Payne, Ann, Perry, Matthew, Sadare (Olaleye), Ibiyemi, Serra, Maria, Springall, Christine, Thompson, Jane, Thomson, Sister Jane, Tree, Alison, Aya, Viviana, Beaney, Ronald, Bower, Lorna, Conway, Lisa-Jane, Donaghey, Sally, Gordon, Hussain, Grau, Isabel, Guerrero-Urbano, Teresa, Harris, Sarah, Hogan, Vesna, Hore, Brendan, Hughes, Simon, Jones, Katie, Kuenzig, Greg, Morris, Stephen, Nathan, Kannon, Nunney, Dawn, Rashid, Jessica, Reynolds, Philip, Rooprai, Bali, Chikkamuniyappa, Bindu, Dalton-Short, Ross, Edwards, Steve, Hassan, Nebah, Magwaro, Sophia, Mangar, Stephen, Rezkallah, Sarah, Stewart, Simon, Thoi, Anne-Maree, Westrop, Anna, Azirar, Hanna, Caumont, Tom, Gupta, Nishi, Hill, Judy, Karp, Stephen, Kullane, Sagal, Macavoy, Tina, Melcher, Lucinda, Neave, Farhad, Newby, Jackie, Van Someren, Chloe, Anderson, Naomi, Annan, Lynda, Cooke, Juniebel, Douch, Emma, Fawcitt, Sara, Gore, Alexandra, Grieve, Sylvia, Jarvis, Claire, McCadden, Angela, Needleman, Sarah, Pigott, Katherine, Powell, Hannah, Ramtohul, Kaliyanee, Rosenfelder, Nicola, Vilarino-Varela, Maria, Ali, Jennyfa, Ali, Maryam, Banda, Laillah-Crystal, Bott, Trevor, Brown, Emmanuel, Bryant, Hanna, Carlino, Giulia, Grant, Cordelia, Hogan, Holly, Khoo, Vincent, Mojidra, Chintan, Montebello, Joseph, Morrison, Jennifer, Olabanji, Matthew, Pillai, Sijy, Siu, Bernard, Stafferton, Ruth, Storrs, Sarah, Townsend-Thorn, Debra, Tree, Alison, Van As, Nicholas, Vijayakumar, Vijitha, Welsh, Liam, Dearnaley, David, Gao, Annie, Horwich, Alan, Huddart, Robert, Lewington, Val, Marshall, John, Murphy, Louise, Parker, Chris, Venkitaraman, Ramachandran, Beaton, Kirsty, Bech-Nielsen, Nanette, Bolton, Olivia, Chetiyawardana, Samantha, Conibear, John, Dekaj, Fatjon, Hillman, Paul, Jayachandran, Resmi, Kaliski, Alexandre, Kiff, Janet, Nicholson, Alastair, Nixon, Jude, Oladimeji, Janet, Riches, Oscar, Smith, Dan, Tipples, Karen, Wells, Paula, Anderson, Chris, Daly, Deirdre, Dover, Serena, Gilmartin, Claire, Golden, Sophie, Gregg, Jane, Issa, Rami, Khoo, Vincent, Oni, Titilayo, Patel, Chandni, Perry, Matthew, Quarrell, Mark, Rolfe, Debbie, Tighe, Helen, Toledo, Jesusa, Tuazon, Juel, Varro, Robert, Bohra, Vikram, Caballes, Mark, Custins, Laura, Hornzee, Gillian, Ivie, Stephanie, Joshi, Manisha, Liau, Joy, Magwaro, Sophia, Naim, Farhan, Patel, Anup, Pathmanathan, Byiravey, Russell, Emily, Stewart, Simon, Thoi, Anne-Maree, Tippins, Anna, Westrop, Anna, Agdiran, Didem, Aggarwal, Ajay, Amoaten, Thomas, Aslam, Natasha, Bonsu, Nicole, Butt, Zainab, Danaswamy, Patricia, Davda, Reena, Gillesen, Annelies, Goel, Roshni, Hall, Julia, Khong, Rachel, Lowi, Suzy, Merrick, Richard, Mitra, Anita, Payne, Heather, Teh, Jonathan, Whinn, Samantha, Woolf, David, Zilkha, Helene, Bech-Nielsen, Nanette, Bolton, Olivia, Danaswamy, Patricia, Dawson-Athey, Linda, Foster, Emma, Gillian, Andrew, Green, James, Hillman, Paul, Hines, John, Holden, Simon, Jayachandran, Resmi, Kazingizi, Memory, O'Neill, John, Olaoni, Thompson, Peters, John, Philp, Timothy, Wells, Paula, Woolf, David, Zaidi, Sadaf, Adeyoju, Adebanji, Adinkra, Victoria, Brough, Richard, Brown, Stephen CW, Collins, Gerald, Hardstaff, Lisa, Hill, Pippa, Kujawa, Magda, McCurrie, Marilyn, Townley, Barbara, Woodhouse, Iain, Zafar, Waheed, Beesley, Sharon, Breen, Vivienne, Brulinski, Patryk, Burrage, Su, Calvert, Clare, Davison, Alison, Dias, Heather, Fossey, Gavin, Hotine, Jodie, Jones, Ifan, Jope, Carmel, Lines, Yvonne, Martins, Sarah, Mercier, Barbara, Mikropoulos, Christos, Murray, Jane, Neshiri, Innocent, Pamphlett, Ian, Phillips, Ann, Rai, Pavnish, Rezkallah, Sarah, Roberts, Verity, Taylor, Henry, Taylor, Katy, Thomas, Carys, Tribe, Lisa, Wood, Pauline, Bottomley, Ian, Buchan, Jonathan, Carpio, Viviana, Choudhury, Ananya, Conroy, Ruth, Cowan, Richard, Davison, Sue, Duncan, Ian, Elliott, Tony, Fair, Kim, Fallaize, Adrian, Flanagan, Laura, Green, Sarah, Harris, Catherine, Hart, Amber, Jones, Cathryn, Livsey, Jacqueline, Logue, John, McCaul, Damian, Nazari, Roonak, Newbery, Carol, O'Connor, Kate, O'Dwyer, Sister Jackie, Oliver, Joanne, Onoge, Ekugbe, Petsa, Maria, Redshaw, Catherine, Smith, Sarah-Ellen, Spoor, Willemijn, Thomas, Sister Viv, White, Holly, Worsley, Lucy, Wylie, James, Bailey, Linda, Bennett, Molly, Corless, Rebecca, Duffy, Annie, Fellows, Kathryn, Gipson, Anna, Haydock, Helen, Knox, WF, Liptrott, Sarah, McCarth, Fiona, McCartin, Fiona, Mistry, Heena, Mthethwa, Thobekile, Partington, Lillian, Piper, Lindsay, Ramani, Vijay, Sahin, Sarah, Sangar, Vijay, Slevin, Kathryn, Tuck, Jonathan, Wylie, James, Atkinson, Lorraine, Barnbrooke, Sarah, Barnes, Alison, Brownless, Caroline, Chadwick, David, Hardman, John, Harland, Keith, Long, Carol, McAuliffe, Sarah, McBride, Julia, McClurey, Sister Patricia, Mohan, Rita, Naylor, Lynne, Peedell, Clive, Robson, Paula, Shakespeare, Devadasan, Thompson, Emma, Van der Voet, Hans, Wilson, David, Barron, Chris, Frew, John, Lambert, Katy, McMenemin, Rhona, Pedley, Ian, Riseborough, Danielle, Roberts, Trevor, Stockley, Emma, Stoddart, Jonathan, Tate, Janine, Walker, Jayashree, Workman, Bridget, Barnett, Debra, Carter, Adam, Cox, Adam, Davey, Alison, Davies, Kirstin, Gilby, Lisa, Hodge, Simon, Kearney, S, Lavender, Helene, Marty, Janet, Nash, Maxine, Rahman, Syhed, Richards, Jayne, Simpson, Julie, Wall, Elaine, Webb, Paula, Wild, Karen, Williams, Rachel, Wilson, Jim, Branagan, Jenny, Camilleri, Philip, Dell, Gillian, Elwell, Christine, Foo, Maxine, Goyena, Ruby, Jones, Andrea, McBain, Hazel, McGrath, Katherine, O'Callaghan, Jane, Ramanathan, Dorai, Tee, Elizabeth, Thominson, Bronwen, Tighe (nee Bussey), Rachel, Archer, Denise, Beety, Jane, Birch, Richard, Bloomfield, Mark, Callam, Sara, Cooper, Adele, Darby, Helen, Healey, Gail, Heasley, Karen, Kapur, Guarav, London, Clare, Nobes, Jenny, Oosterom, Katrien, Ostrowski, Joe, Shobrook, Bridget, Turner, Sarah, Wade, Rob, Walker, Suzanne, Walton, Sharon, Websdale, Cheryl, White, Joanna, Alder, Leanne, Chivers, Rachael, Gooch, Carol, Howard, Lucy, Hutchinson, Camille, Jevons, Cody, Kumar, Daniel, Marley, Hazel, Mills, Jamie, Purves, Hanna, Sayers, Ian, Sundar, Santhanam, Szolin-Jones, Jacob, Walker, Georgina, Wood, Catherine, Choudhury, Ananya, Conroy, Ruth, Cook, Wendy, Gill, Lisa, Johnson, Joanne, Johnstone, Dawn, Jones, Richard, Livsey, Jacqueline, Mistry, Leena, Scarratt, Lyndsay, Aiku, Abimbola, Ajzensztejn, Daniel, Al-Chamali, Hiba, Andrade, Gerard, Barber, Dave, Bekulart, Sylwia, Bhatnagar, Gagan, Boutflower, Jane, Brewster, Simon, Butterfield, Anne, Camilleri, Philip, Carroll, Weronika, Cole, David J, Coutts, Tim, Doyle, Kerrie, Durrant, Lisa, Green, Trish, Hyde, Katherine, Jampana, Raj, Jastrzebska, Patrycja, Kiltie, Anne, Kyffin, Phillippa, Langridge, Nicole, Lawrey, Sarah, Markus, Sarah, Marston, Kerrie, Mooney, Matthew, Mukkath, Sandra, Murphy, Ann, Owens, Rob, Panakis, Niki, Rabsztyn, Weronika, Ruane, Sarah, Sabbagh, Ahmad, Sabharwal, Ami, Samkange, Grace, Sankighatta, Naveen, Skwarski, Michael, Stuart, Robert, Wellman, Sandie, Wilson, Jo, Cavanagh, Kerrie, Hollingdale, Abigail, Allen, Susan, Barter, Elisa, Benson, Richard, Gregory, Debbie, Ingle, Charlotte, Lawrence, Steph, Rooney, Paula-Joanne, Bishop, Emma, Brennan, Maria, Cogley, Lyn, Hammonds, John Christopher, McInerney, Paul, McLarty, Esther, Natale, Salvatore, Pascoe, Sarah, Purcell, Keith, Sells, Henry, Tyner, Sharah, yates, Victoria, Beamish, Neal, Blaney, Hilary, Brock, Sue, Clapp, Felicity, Clarke, Elizabeth, Coffin, Teresa, Crellin, Perric, Davies, Joe, Downs, Nichola, Gillespie, Sally, Goodsell, Josie, Harinarayanan, Sathish, Heckford, Louise, Iskender, Amanda, Orford, Sara, Pressdee, Sandy, Rix, Sophie, Wheelwright, Roger, Woodward, Elizabeth, Wright, Seonaid, Blight, Kathy, Dobson, Tracey, Hale, Jennifer, Harris-Burland, Angie, Khoury, Ghassan, Madhava, Kudingila, Meadows, Lorna, Nagar, Yoodhvir, Roca, Mila, Stacey, Wendy, Stephenson, Anna, Uherek, Maja, Virgo, Azarel, Watkinson, Catrin, Birtle, Alison, Chauhan, Zainab, Cornthwaite, Stephanie, Curtis, Sandra, Ellard, Rose, Fish, Nathan, Hefferon, Billy, Parikh, Omi, Searle, Claire, Spickett, Helen, Walmsley, Catherine, Wise, Marcus, Atkinson, Jane, Brown, Richard B, Cartwright, Debbie, Coomber, Kristy, Hunt, Allison, Kowalczyk-Williams, Wioletta, Lewis, Christina, Parr, Stephen, Purdon, Helen, Rogers, Paul, Vowell, Emma, Capaldi, Lisa, Featherstone, Wendy, Hamilton, Joanna, Harrison, Alison, Hindle, Margaret, Hodson, Hayley, Isaew, Andrea, Knapp, Jeanette, Moss, Sarah, Gibbs, Stephanie, Gujral, Sandeep, Jannapureddy, Revanth, Kelkar, Anand, Martinou, Maria, Mills-Baldock, Tina, Nicholson, Alastair, O'Brien, Neale, Subramaniam, Ramachandran, Tahir, Saad, Vandal, Mohammad Tanvir, Vu, Thi, Allen, Rachael, Betts, Chris, Bowmer, Amanda, Clarke, Noel, Cordwell, Amanda, Cowan, Richard, Dharmaprasad, Soney, Duncan (nee Keatley), Claire, Elliott, Tony, Farnworth, Christine, Farrell, Helen, George, Siny, Goulden, Kay, Harter, Leah, Kaushal, Malan, Kirk, Sister Sarah, Lau, Maurice, Lydon, Anne Marie, O'Flynn, Kieran, Platt, Danielle, Redshaw, Catherine, Richardson, Karen, Shackley, David, Stevenson, Garry, Taylor, Sister Melanie, Thompson, Chloe-Anne, Tran, Anna, Vinod, Cellins, Wadsworth, Oliver, Youd, Sister Jill, Attlee, Julie, Bhatnagar, Adityanarayan, Bunn, Sarah, Campbell, Allister, El-Saghir, Mohammed, Fennelly, Ruth, Guy, Peter, Gwilt, Julie, Mattocks, Lehentha, Mcintosh, Gregor, Murphy, Brenda, Reed, Catherine, Strong-Sheldrake, Sophia, Tedd, Gemma, Dent, Kathleen, Dixit, Sanjay, Hood, Marion, Martin, Karen, Pearson, Sandra, Potoczna, Dorota, Spencer, Sue, Towse, Jo, Whotton, Nikita, Bowen, Katie, Clark, Su, Clarke, Rachael, Ferguson, Catherine, Firth, Alexandra, Gibbins, Kate, Kirkbride, Peter, Martin, Jackie, Martindale, John, Smedley (nee McCabe), Janine, Smith, Suzanne, Spalton, Catherine, Tay, Jessica, Wood, Sister Kim, Adams, Marion, Bates, Emma, Chennattukungu, Indukala, Clancy, Joanna, Cross, Vanessa, Hughes, Hayley, Jose, Sanal, Kurian-Downer, Sunita, Michael, Elena, Moore, Sister Helen, Nicholas, Karen, Pope, Suzanne, Potts, Sally, Prashant, Ravi, Singh, Harpreet, Smith, Sandra, Srihari, Narayanan, Weaver, Emma, Abbas, Ali, Barnes, Nicky, Brown, Richard B, Dallas, Nicola, Jackson, Sister Ann, Kader, Nicole, Karim, Omer, Laniado, M, Litchfield, Jayne, Mahmood, Sana, O'Donnell, Helen, Robinson, Victoria, Sears, Alison, Sharif, Shahid, Sierra Pala, Ana, Sinclair, Julie-Ann, Smith, Sister Catherine, Ashcroft, Jan, Boardman, John, Bowes-Cavanagh, Jeanette, Brown, Rebecca, Chedham, Alison, Darch, Flora, Farrar, Michelle, Foot, Jayne, Goldsworthy, Simon, Graham, John, Gray, Emma, Green, Sara, Jelski, Joseph, Kalejaiye, Odunayo, Keni, Manjusha, Locke, Angela, Mahoney, Sue, McMeekin, Faith, Periasamy, Manivannan, Russell, Tamlyn, Ruszala, Elizabeth, Segaran, Surayne, Tighe, Mary, Varughese, Mohini, Wallbutton, Rebecca, Webster, Christine, Whitcher, Alison, Wiggins, Sarah, Wrigley, Martha, Zietz, Maria, Abab, Julie, Cumming, Kirsty, Galloway, Lucy, Ganabady, Malavika, Gwilt, Julie, Haskell, Annelise, Heath, Catherine, James, Naomi, Kennedy, Julie, McFarlane, Victoria, Morales-Azofra, Fabiola, Morton, Susan, Mundy, Carina, Noble, Mark, Paschalis, Alec, Patrick, Julie, Reader, Leanne, Stephenson, Anna, Taylor, Lisa, Wakefield, Shauna, Ahmed, Imtiaz, Bowman, Sue, Chan, Olivia, Cyriac, Abby, Davies, Tracey, Maitland, Katrina, Prejbisz, Jan, Reece, Sheila, Shires, Heather, Tsang, David, Anscombe, Eleanor, Brough, Richard, Brough, WA, Clitheroe, Pat, Cocks, Tracie, Collins, Gerald, Connolly nee McKenna, Sarah, Corcoran, Sam, Coughlan, Tricia, Gilmour, Christina, Goodwin, Emma, Graham, Susan, Hatimy, Umi, Haydock, Helen, Hodgkinson, Sheila, Kilmartin, John, Logue, John, Orrell, Lucy, Rotherham, Carol, Smallwood, Sarah, Taylor, Jill, Wiss, Elliott, Adab, Fawzi, Bhana, Rajanee, Dhinakaran, Kathirvelu, Evans, Marion, Myatt, Alison, Parkinson, Katrina, Peake, Angela, Sellars, Elizabeth, Smith, Rowena, Storer, Julie, Thomasson, Georgia, Vengalil, Salil, Walton, Jenny, Ward, Angela, Boam, Samantha, Burgoyne, Jamie-Rae, Chadwick, Eliot, Gill, Shafiq, Haigh, Steve, Hollis, Keri, Lim, Jun, McCabe, Alastair, Munson, Lyndsey, Nash, Dominic, Saunders, Daniel, Smith, Susan, Sundar, Santhanam, Wade, Lynne, Walker, Georgina, Evans, Elizabeth, Franklin, Alex, Harris (n. Marchant), Emily, Johnstone, Maria, Jones, Lewis, Lemon, Nicola, Phan, Mau-Don, Pudney, Delia, Spence, Rachael, Stretch, Alison, Tait, Ellen, Williams, Bethan, Belcher, Rebecca, Cole, David J, De Silva-Minor, Shiroma, Dodge, Sister Jan, Grayland, Sarah, Jones, Ania, Khan, Omar, Owen, Tim, Palmer, Debbie, Parajes, Cerila, Pegler, Suzannah, Poole, Abbie, Sargent, Sister Tracey, Starling, Ellen, Taylor, Becky, Winter, Sister Helen, Zinyemba, Vivian, Allison, Michele, Blundell, Martyn, Brookman, Catherine, Buckley, Jon, Chamberlain, Shelley, Cuffe, Donna, Davies, Stacey, Fairfax, Claire, Greedus, Helen, Griffin, Hannah, Koehler, Ingrid, Lydon, Anna, Michels, Jorg, Pym, Julia, Roberts, Fiona, Srinivasan, Rajaguru, Thornton, Lorraine, Vandecandalaere, Elaine, Watts, Erica, Welsh, Linda, Anderson, Jim, Anderson, Juliette, Ball, Julie, Benton, Louise, Bowers, Richard, Burlace, Barbara, Casanova, Nathalie, Chahal, Rohit, Coyle, Catherine, Dickinson, Peter, Fosker, Chris, Heeley, Janine, Henry, Ann, Kanaga-Sundaram, Subramanian, Littler, Stephen, Rodda, Sree, Slack, Jonathan, Sundaram, Subramanian Kanaga, Taylor, Beverley, Weston, Philip, Chan, Andrew, Chettle, Judith, Gamble, Tina, Griffiths, Theresa, Hartwell, Lyn, Johnson-Rollings, Ashley, Jones, Julia, Millage, Helen, O'Neill, Eilish, Simmons, Elaine, Stockdale, Andrew, Walsh, Donna, Webb, Kerrie, Williams, Jo, Anderson, John, Dymond, Harvey, Eleftheriadis, Symeon, Hilman, Serena, Lloyd-Jones, Hugh, Wells, Tom, Bennett, Sarah, Dunn, Sharon, Fildes, Diane, Hassall, Alison, Herbert, Gaynor, Hughes, Kathryn, Innes, Helen, Kelly, Alison, Littler, John, Lomax, Laurie, Miller, Nikki, Nutman, Chris, Stott, Matthew, Syndikus, Isabel, Tolan, Shaun, Weston, Alison, Baker, Ivanna, Carter, Vanda, Chatfield, Jenny, Churn, Mark, Cooke, Peter, Grant, Anna, Homer, David, Keng-Koh, Pek, Kirk, Christine, Lomas, Claire, McCormick, Marian, Mohseeni, Arizoo, Pawaroo, Renita, Radford, Liz, Rogers, Jason, Samanci, Ali, Sayers, Ian, Sharman, Emma, Spencer, Hazel, Spruce, Debbie, Worthington, Hannah, Bak, Dagmara, Bowen, Jo, Capaldi, Lisa, Cleary, Kristy, Davies, Sue, Forkes, Janet, Gauntlett, Monica, Gupta, Kamalnayan, Healey-Mariano, Jennifer, Hodson, Hayley, Holdsworth, Amanda, Ledger, Kate, Morrow, Hugh, Perry, Heather, Rimell, Patricia, Rosoman, Alison, Taylor, Jacob, Tranter, Helen, Tyler, Jayne, White, Ann, Bloomfield, David, Crowe (nee Hughes), Dawn, Flynn-Batham, Marian, Folkes, Linda, Funnell, Sarah, Gilbert, Jeanette, Gomez-Marcos, Raquel, Gonzalez, Celia, Hoskins, Chloe, Moore, Sally, Nikapota, Ashok, Plataniotis, George, Rippin, Sarah, Smith, Matthew, Tsawayo, Tan, Turner, Nikki, Wakelen, Paula, Brady, Joanne, Camilleri, Philip, Carpenter, Janice, Cserbane, Anita, Fernandez, Claire, Hogbin, Emma, Hyde, Katherine, Joshi, Manisha, Kavanagh, Roisin, Kurup, Rahul, Manyangadze, Sarah, McLain-Smith, Susan, Ngumo, Alice, Panakis, Niki, Protheroe, Andrew, Pwint, Thinn, Sabharwal, Ami, Trewsmith, Neil, Wynn, Hazel, 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Spillane, Maria, Sullivan, Frank, Teh, Chiaw Woon, Wright, Ann, Harving, Niels, Hejlesen, Finn, Kempel, Mette Moe, Steffensen, Kirsten, Bentzen, Lise, Borre, Michael, Buus, Simon, Fode, Kirsten, Kaa Bach, Birgit, Lassen, Yasmin, Laursen, Vibeke, Lemng Kruse, Helle, Lucakova, Slavka, Nørmark Iversen, Helle, Brasso, Klaus, Christensen, Anne Juel, Gruschy, Lisa, Klovgaard, Karina, Lunau, Anne Sofie, Meidhal Petersen, Peter, Moller Christensen, Trine, Poder, Lone Lund, Ribers, Kristine, Stilling, Sine, Thim, Stine, Torin Lehmann, Anna, Vandborg, Maria, Christensen, Tine, Kokholm, Kathrine Friser, Lindberg, Henriette, Nybom, Kirstine, Rønnengart, Eva, Saxe, Charlotte, Baird, Noelle, Braun, Michael W, Cheung, Arthur, Fourt, Monica, Jackson, Cathy, Jepson, Debbie, Johnson, Arlissa, Karvat, Anand, Kwan, Winkle, McIndoe, Sue, Mitchell, Donna, Sandhu, Sandeep, Serpanchy, Rosanne, Wu, Helen, Beausoleil, Rachelle, Crawford, Melanie, DiMarco, Christine, Ding, Ian, Gladwish, Adam, MacIsaac, Patricia, MarshGray, Kimberley, Morton, Gerard, Murphy, Cara, Pascoe, Caitlin, Pokhrel, Sujata, Stevens, Christiaan, Yoon, Frederick, Yu, Jason, Dubey, Arbind, Sivananthan, Gokulan, Bahary, JeanPaul, Barkati, Maroie, Beauchemin, MarieClaude, Benth, Silvine, Carbonaro, Adriana, Delouya, Guila, ElSokhn, Nidale, Frazzi, Alexandra, Lambert, Carole, Lavertu, Sophie, Menard, Cynthia, Pan, Siew Siew, Rousseau, Pierre, Saad, Fred, Taussky, Daniel, Trudel, Diane, Amanie, John Oliver, Batz, Margaret, Borynec, Carol, Danielson, Brita, Garcia, Leni Santiago, Gramlich, Colin, Lang, Monika, Larson, Beverly, Mallett, Debbie, McCrudden, Sylvia, Murtha, Albert, Parker, Shelley, Parliament, Matthew B, Patel, Samir, Pearcey, Robert, Pervez, Nadeem, Rose, Jim, Shewchuk, Caroline, Smith, Carlie, Usmani, Nawaid, Williams, Candra, Yee, Don, AlRashdan, Abdulla, Avery, Alison, Beaton, Heather, Bond, Brittany, BrucePayne, Kim, Burbridge, Susan, Bursey, Kara, Carvery, Lane, Dill, Kendra, Dugas, Stevie, Harding, Claudia, Hodder, June, Hollenhorst, Helmut, Hubley, Lynn, Joseph, Paul K, Little, Erin, MacDonald, Angela, MacIsaac, Kathy, MacVicar, Jennifer, McCracken, Jillian, Moffatt, Emily, Nieforth, Joan, Patil, Nikhilesh, Rijt, Kelsey van der, Roberts, Victoria, Rose, Tina, Rutledge, Robert DH, Salyzyn, Camryn, Simpson, Robin, Sutherland, Donna, Walker, Heather, Wilke, Derek, Yeo, Tanya, Yunace, Lorrie, Zinck, Connie, Bier, Bianca, Bucci, Catherine, Corbett, Thomas B, Dayes, Ian S, Eady, Robin, Gudelis, Susan O, Hill, Elaine, Kinrade, Yvonne, Laughlin, Anne, Lukka, Himu, Makepeace, Barbara, Marshall, Lynn, Nielsen, Linda, Oliverio, Carmela, Patel, Malti Behn, Tsakirdis, Thedoros, Wong, Jason W T, Allen, Kirsten, Bachand, Francois, Carefoot, Layton, Cotts, Shannon, Creelman, Brianna, Crook, Juanita, GeorgeChayka, Danielle, Halperin, Ross, Hartt, Nancy, Hayes, Jill A, Kim, David, Kim, TuongVan, Kronstal, Flo, Lee, Bernard, Lew, Tanya, McClelland, Marie, Opitz, Debbie, Overend, Aldyn, Reed, Melanie, Watson, Michaella, Wilkie, Karen, Winn, Carol, Yanchuk, Janet, Bonner, Scott, Brander, Mike, Brundage, Michael, Carlson, Cindy, Edwards, Jackie, ElKerdawy, Hala, Harpell, Rhonda, Hartman, Carrie, Kalyvas, Maria, KirbyBello, Denise, Kumar, Vikaash, Leach, Deborah, MacVicar, Karen, Mahmud, Aamer, Maize, Christine, Moelker, Yvonne, Murano, Abby, Paul, Nancy, Ross, Ashley, RossSmith, Marleen, Shenfield, Carey, Spencer, Craig, Tennant, Virginia, Vermette, Tracy, Willing, Stephanie, Zaza, Khaled O, Zeltser, Fred, Gearing, Jennifer, Girolametto, Carla, Gopaul, Darindra, Hamilton, Ronald, Hendel, Debra, Janke, Susan, Knackstedt, Jochen, Kuk, Joda, Morrison, MaryBeth, Mumin, Anissa, Nemirov, Stephanie, Rachakonda, Ramana, Shantz, Brenda S, Siddiqui, Atif, Thallury, Sheeba, Ahmad, Belal, Bailey, Laura, Bauman, Glenn, Camara, Mary Jane, Corkery, Danylle, DSouza, David, DiLullo, Elenor, Eichenberger, Lois, Francis, Peggy, Grant, Susan, Gratton, Albert, Gurzanski, Christina, Hare, Jennifer A, Johnson, Craig, Kenny, Shannon, Lock, Michael I, Loughlin, Kate, Mardell, Stephen, Mayer, Heather, Rodrigues, George B, Sax, Lori, Sebborn, Kes, Sexton, Tracy, Venkatesan, Varagur M, tenHaaf, Darlene, Chatelain, AnneMarie, Fortin, Jacqueline, Houle, Stefanie, Khaouam, Nader, Lachance, Nicole, Laliberte, Benoit, Lemaire, Celine, Nguyen, David H A, Sylvestre, Alma, Vavassis, Peter, Yassa, Michael, Adnaan, Jamila, Briand, Wayne, Casey, Linda, Chipman, Penny, Corwin, Charlotte, Duclos, Marie, Faria, Sergio Luiz, Ghoul, Mokhtar, Joncas, MarieClaude, Koulouris, Zoe, Larocque, Stephanie, Lee, Brenda, Olha, Carolynna, Robert, MarieFrance, Sharma, Rajesh, Shenouda, George, Souhami, Luis, Albrecht, Virginia, Froese, Jane, Froude, Nancy, Howitt, Pamela, Iqbal, Fawaad, Kift, Shannon, Koll, Wayne, Li, Audrey, MacGregor, Barbara, Manganaro, Aileen, McKee, Dianne, Mendoza, Edeliza, Mui, Jimmy, Myrehaug, Sten, Singson, Angelina, Slessor, Janet, Somasiri, Ashane, Stevens, Nicole, Berghout, Koralee, Bourque, JeanMarc, Carkner, Amy, E, Choan, Eapen, Libni, Eze, Nancy, Fish, Matt, Haddad, Alain, Hicks, Kimberly, Iordanidi, Elina, Kanji, Femina, Kendal, Wayne S, MacMullin, Lisa, MacRae, Robert M, Malone, Shawn, Morgan, Scott, Nguyen, Julie, OBrien, Anna, Page, Nancy, Perry, Gad A, Reeves, MarieClaude, Roach, Joanne, Sanchez, Maria, Spearman, Mary, Spencer, Patti, Tikoo, Archana, Turriff, Lisa, Wright, Natalie, Bedoya, Luis Diaz de, Cossette, Danielle, Cusan, Leonello, Desrosiers, Isabelle, Dufour, Nathalie, Foster, William, Gomez, JoseLuis, Hathout, Lara, Lajoie, MarieAndree, Martin, AndreGuy, Pouliot, Sophie, Vigneault, Eric, Bouchard, Myriam, Bujold, Rachel, Carmel, Michel, Cote, Genevieve, Dion, Helene, Ebacher, Annie, Gauthier, Isabelle C, Ladouceur, Cynthia, Lamoureux, Alexandra, Larouche, Julie, Marquis, Tania, Nabid, Abdenour, Pearson, Diane, Sabbagh, Robert, TetreaultLaflamme, Audrey, Baker, Erin, Blackwood, Geoffrey, Galway, Denise, Greenland, Jonathan, Hannaford, Zeta, Hoskins, Ashley, House, Gail, Kamran, Asim, Manning, Kimberley, Nelder, Matthew, Noel, Lorilee, Norman, Alia, ODea, Jamie, Pinnell, Erin, Pochini, Craig, Putt, Dawne, Rahman, Arifur, Rickert, Lauren, Sathya, Jinka R, Teasdale, Breanne, Thoms, John, Whiteway, Chrystal, Whittle, Stacy, Cheung, Patrick CF, Chu, William, Chung, Hans T, Commisso, Angela, Danjoux, Cyril, Escueta, Vivette, Klotz, Laurence, Leung, Michael, Liu, Stanley, Loblaw, Douglas Andrew, Malek, Leila, Morton, Gerard, Nam, Robert K, Szumacher, Ewa, Tseng, Eric Chia Lin, Vesprini, Danny, Abed, Jessy, Ang, Daniel, Bayley, Andrew J, Berlin, Alejandro, Bristow, Robert, Catton, Charles, Chan, Heidi, Chui, Amadeus, Chung, Peter, Degendorfer, Sarah, Gospodarowicz, Mary, Gregorcic, Emily, Gumapac, Nicole, Helou, Joelle, Hsien, John, Kong, Vickie, Lalani, Nafisha, Lao, Bernadeth, Lawson, Daeria, Menard, Cynthia, Merante, Pat, Milosevic, Michael, Mirmooji, Ramesh, Muraj, Zaynab, Peres, Sarin, Petroff, Avi, Petrovska, Aleksandra, Pineda, Sandra, Quintos, Judy, Raman, Srinivas, Ramotar, Sarah, Ruiz, Maria Jose Gaitan, Sabate, Kathryn, Shukla, Arundhati, Tharahan, Nanthini, Thevarajah, Vaishaali, Tiessen, Kyoko, Topalovich, Aleksandra, Torres, Cynthia, Tse, Karen, Tsuji, Debbie, Velec, Erin, Wallace, Kris, Warde, Padraig, Bisson, MarieEve, Dahmane, Rafika, Gagne, Vanessa, Harvey, Julie, Lebrun, Benoit, Marineau, Line, Montour, Julie, Samson, Julie, Sicard, MarieEve, Thibeault, Andreanne, Vincent, Francois, Vincent, LindaSuzanne, Blood, Paul A, Canavan, Joycelin, Clements, Mia AnnaMaria, Glick, Daniel, Holloway, Caroline, Holwerda, Eleanor, Joe, Howard, Lacey, Cathy, Lam, Jacqueline, Leong, Nelson, Lim, Jan, Lomas, Alia, Pai, Howard H, Priestley, Emilie, Shahid, Negin, Vallieres, Isabelle, Duncan, Graeme, Gleave, Martin E, Goldenberg, S Larry, Karunakaran, Subashini, Keyes, Mira, KimSing, Charmaine, McKenzie, Michael, Morris, William James, Nakashima, Lynne, Peacock, Michael, Pickles, Thomas A, Rodda, Sree, Sibug, Sheena, So, Alan I, Tyldesley, Scott, Zhang, Tina Wanting, Ahmed, Shahida, Ammeter, Barb, Anderson, Leanne, Ann, Taehee, Bakija, Zeljka, Bashir, Bashir, Benjaminson, Patricia, Bergen, Leah, Cadiz, Lovely, Chahine, Jacqueline, Cherepak, Kathy, Chornopyski, Tracy, Chowdhury, Amitava D, Davies, Heather, Dawe, David, Drachenberg, Darrel E, DuMontier, Joelle, Dubey, Arbind, Eska, Tiffani, Francisco, Cristina, Gamez, Raquel, Garrett, Gina, Giovannini, Julia, Graham, Jeffrey, Guarino, Robyn, Hunter, William, Johnston, Laurel, Kitkowski, Caitlin, Klapp, Kathi, Koul, Rashmi, Kuzyk, Valerie, Last, Debbie, Li, KuanLin, Long, Heather, Majumdar, Arpita, Marek, Kathleen, McNish, Jennifer, Mills, Laurie, Morales, Maria, Nashed, Maged, Nichol, Rhonda, Ong, Aldrich Dixon, Ouelette, Ashley, Patel, DeepKumar, Pawl, Marilyn, Peak, Lisa, Priebe, Shauna, Quon, Harvey, Rizzuto, Stacey, Rudnicki, Rayleen, Santos, Priscilla, Sharma, Atul, Sivananthan, Gokulan, Squires, Mandy, Trakalo, Kathy, Turner, Christy, Vaughn, Jamie, Walker, Lori, Watson, Melanie R, Wei, Joyce, Weir, JoAnn, Woloshyn, Rose, Wood, Allison, Zhang, Hanbo, and Zwarych, Darlene

Abstract

Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear.

Published
2024
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38. Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial

Author

Parker, Chris C, Kynaston, Howard, Cook, Adrian D, Clarke, Noel W, Catton, Charles N, Cross, William R, Petersen, Peter M, Persad, Rajendra A, Pugh, Cheryl A, Saad, Fred, Logue, John, Payne, Heather, Bower, Lorna C, Brawley, Chris, Rauchenberger, Mary, Barkati, Maroie, Bottomley, David M, Brasso, Klaus, Chung, Hans T, Chung, Peter W M, Conroy, Ruth, Falconer, Alison, Ford, Vicky, Goh, Chee L, Heath, Catherine M, James, Nicholas D, Kim-Sing, Charmaine, Kodavatiganti, Ravi, Malone, Shawn C, Morris, Stephen L, Nabid, Abdenour, Ong, Aldrich D, Raman, Rakesh, Rodda, Sree, Wells, Paula, Worlding, Jane, Parulekar, Wendy R, Parmar, Mahesh K B, Sydes, Matthew R, Amos, Claire, Beaney, Katherine, Bellenger, Katharine, Brawley, Chris, Chung, Christina, Cook, Adrian, Embleton, Andrew, Forcat, Silvia, Goldstein, Cindy, Grabey, Jenna, Hague, Dominic, Herasimtschuk, Anna, Islam, Zaheer, Jovic, Gordana, Maniatis, Christos, Masters, Lindsey, Mohamed, Fatima, Morgan, Rachel, Murphy, Claire, Noor, Dipa, Parmar, Max, Patterson, Paul, Pickering, Holly, Pugh, Cheryl, Rauchenberger, Mary, Ribeiro, Helena, Roach, Carol, Seray-Wurie, Fatimah, Shaji, Preetha, Sims, Hannah, Spittle, Ben, Sydes, Matthew, Tappenden, Nancy, Tsang, Lilian, Uscinska, Barbara, Brown, Teddy, Casey, Sue, Davidson, Cathy, Dellar, Conor, Fletcher, Mandy, Meyer, Ralph, Murphy, Karen, Parulekar, Wendy, Richardson, Harriet, Richardson, Karen, Whelan, Kate, Bissett, Donald, Bonner-Shand, Shelagh, Grant, Judith, Lynch, Rory, MacDonald, Graham, McWilliam, Marie, Moir, Rachel, Rodwell, Sue, Shearer, Kirsty, Smith, Margaret, Binns, Louise, Briggs, Maxine, Brown, Simon, Casanova, Nathalie, Clark, Katy, Hartley, Jasmine, Henry, Ann, Henson, Helen, Hill, Pipa, Jeyasanger, Ganesan, McAlister, Judy, Parkinson, Sharron, Shaw, Alison, Alcock, Christopher, Brady, Joanne, Camilleri, Philip, Carpenter, Janice, Hogbin, Emma, Hyde, Katherine, Kavanagh, Roisin, Ngumo, Alice, Padilla-Harris, Cheryl, Panakis, Niki, Pwint, Thinn, Sabharwal, Ami, Stammers, Tracey, Stone, Helena, Varley, Gail, Weaver, Andrew, Wynn, Hazel, Allan, Elaine, Ansari, Jawaher, Cannon, Philip, Carruthers, Ross, Coubrough, Claudia, Cowan, Chloe, Glen, Hilary, Graham, Janet, Hardie, Maryon, Love, Clare, Macleod, Nicholas, Mahmood, Rana, McClements, Jane, McGlynn, Brian, McKernan, Margaret, Mcleod, Nick, Othman, Aqilah, Ross, Kristy, Roxburgh, Patricia, Templeton, Maureen, Tufail, Aisha, Turley, Claudia, Wilson, Mark, Ali, Zulfiqer, Andrews, Kelly, Burns, Rebecca, Butterworth, Caryl, Coventry, Thomas, Evans, Angela, Jones, Gareth, Lewis, Sion, Oommen, Nikhil, Owen, Susan, Saxton, Wendy, Tapping, Sister Hayley, Thomas, Dianne, Thomas, Rachel, Walker, Beth, Williams, Rachel, Collard, Susan, Ford, Victoria, Goodhind, Frances, Holbrook, Becky, Kershaw, Elizabeth, Ley, Samantha, Martinez, Maria, McCormack, Anne, Sheehan, Denise, Toy, Elizabeth, Van-Koutrik, Lynne, Varughese, Mohini, Aitken, Katherine, Barlow, David, Beattie, Louise, Bownie-Mukumbu, Godfrey, Bryan, Rachel, Corner, Victoria, Edwards, Abigail, Fazekasne Fulep, Adrienn, Guerrero-Urbano, Teresa, Gwilt, Julie, Happle, Liz, Jackman, Dee, Krysta, Beata, Paisey, Sangeeta, Shaffer, Richard, Smith, Jackie, Westley, Rosalyne, Yusof, Hilawati, Appleby, Rowan, Avis, Joanne, Beresford, Mark, Brydon-Hill, Ruth, Cox, Christine, Curtis, Samantha, Elwell, Christine, Frim, Olivera, Hamilton, Beatrice, Hudson, Zoe, Jenner, Abigail, Mantle, Mark, Mason, Jessica, Masson, Susan, McFarlane, Jonathan, Newman, Hugh, Pocock, Abigail, Robertson, Bryony, Tomlinson, Eve, Wassall, Rebecca, Williams (Née Allen), Sister Tania, Brown, Grace, Clarke, Peter, Cole, Aiden, Cousins, Jane, Gilchrist, Gail, Hagan, Chris, Hanna, Emma, Harney, Jackie, Hetherington, Stacey, Houghton, Fionnuala, Hynds, Sharon, Jain, Suneil, Johnston, Ruth, Keane, Patrick, Lyons, Ciara, McAleese, Jonathan, McAllister, Jo, McKenna, Karen, Mitchell, Darren, Murray, Stacey, O'Sullivan, Joe, Rajan, Nambi, Shum, Poh Lin, Stewart, David, Stranex, Stephen, Totten, Grace, Chandrashekara, Madhura, Drew, Ellen, Drew, Mary (Ellen), Fletcher, Julie, Gamble, Tina, Lokes, Rachel, Schumacher, Ann, Shetty, Kavitha, Sohanpal, Sundip, Whitehouse, James, Zarkar, Anjali, Ford, Daniel, Glaholm, John, Lenton, Daniel, O'Beney, Rachael, Sohanpal, Sundip, Taylor, Helen, Thomas, Helen, Whitehouse, James, Chetiyawardana, Samantha, Doherty, A, El-Modir, Ahmed, Ford, Daniel, Glaholm, John, Gunn, Melanie, James, Nicholas, Kedge, Liz, Lokes, Rachel, Mannan, Aliyah, Marange, Josephine, Morrison, Andrew, Okubanjo, Maryanne, Olaniyi-Oduntan, Darlletta, Peterkin, Zhane, Preece, George, Qureshi, Zayn, Ross, Liliam, Samra, Tarandip, Southgate, Elizabeth, Stephens, Rebekah, Stevenson, Robert, Watson-Jones, Phillip, Zarkar, Anjali, Abdulwahid, Danya, Ainsworth, Sarah, Ashworth, Sue, Beard, Karen, Charnley, Natalie, Desai, Parth, Fielding, Bethany, Flaherty, Jan, Forrest, Diane, Frankland, Helen, Haidar, Imran, Hargreaves, Jeanette, Henry, Joanne, Hugill, Angela, Jewers, Karen, Keith, Sarah, Kilroy, Stephen, King, Jennifer, Parikh, Omi, Riley, Karen, Ryan-Smith, Janet, Thomas, Jacqueline, Thompson, Catherine, Tickle, Vivienne, Waring, Lynsey, Wise, Marcus, Abdulwahid, Danya, Ainsworth, Sarah, Ashworth, Sue, Beard, Karen, Dawson, Louise, Desai, Parth, Ditchfield, Julie, Fielding, Bethany, Flaherty, Jan, Forrest, Diane, Frankland, Helen, Haidar, Imran, Hargreaves, Jeanette, Henry, Joanne, Hugill, Angela, Jewers, Karen, Keith, Sarah, Kilroy, Stephen, King, Jennifer, Parikh, Omi, Riley, Karen, Ryan-Smith, Janet, Thompson, Catherine, Tickle, Vivienne, Waring, Lynsey, Wise, Marcus, Al-Samarraie, Amir, Ali, Zulfiqer, Bolger, Annette, Davies, Llinos, Flavin, Aileen, Heron, Jane, Hughes, Faye, Jackson, Kim, Lewis, Joanne, Manley, Rachel, Oommen, Nikhil, Rutter, Charley-Anne, Smith, Nick, Srinivasan, Vaiku, Stockport, Jane, Tapping, Sister Hayley, Thomas, Heather, Toussi, H, Wood, Cathryn, Archer, Simon, Fletcher, Joanne, Ginnelly, Helen, Kirkby, Amy, Knight (n. Sherburn), Victoria, Lawrence nee Palmer, Tara, Mashegede, Beverley, Metcalf, Karen, Panades, Miguel, Sreenivasan, Thiagarajan, Szymiczek, Kinga, Thomas, Isobel, Young, Anita, Broadley, Eve, Brock, Sue, Davies, Joseph, Jones, Stephanie, McCully, Ruby, Naraine, Nicky, Preece, Kate, Purandare, Laura, Rabbi, Taslima, Savage, Sarah, Vamplew, Luke, Bamford, Linda, Benton, Richard, Cotterill, Lauren, Henry, Ann, Inman, Hayley, Karsera, Louise, Kay, Anne Marie, Kenyon, Lucille, Lazarte, Jannika, McNulty, Dawn, Moore, Eleanor, Nallathambi, Chandran, Naylor, Deirdre, Owen, Lisa, Parikh, Shefali, Pendrill, Amy, Price, Joanne, Robertshaw, Helen, Rodda, Sree, Sewell, Jane, Teo, Mark, Waldron, Eleanor, Bloomfield, David, Blythe, Tracy, Brown, Joanne, Carr, Philippa, Chambers, Carla, Dlodlo, Jessica, Frattaroli, Paul, Gilbert, Duncan, Hart, Andrew, Hodges, Samantha, Hooper, Simon, Hunter, Catherine, Lactao, Ranee, Leitao, Madalena, McKinna, Fiona, Nikapota, Ashok, Peterson, Jane, Robinson, Angus, Tremlett, Jean, Webb, Andrew, Wilkins, Marie, Young, Bobbie, Bahl, Amit, Baxter, Matt, Beresford, Mark, Bowers, Dawn, Challipalli, Amarnath, Coe, Marc, Cowley, Sue, Gillatt, David, Griffiths, Dorothy, Henson (nee Savidge), Verity, Hilman, Serena, Hollister, Robert, Kisanga, Mary, Lee, Vivienne, Lowe, Amelia, Macefield, Rhiannon, Masson, Susan, Pegler, Ruth, Robertson, Peter, Saldanha, Helen, Simmonds, Mary, Sims, Laura, Wheeler, Lucie, Wilson, Paula, Woods, Martin, Yarrow, Sue, Zelley, Sarah, Abd Alazeez, Mohamed, Alderton, Kate, Bahl, Amit, Beresford, Mark, Brain, Carol, Challipalli, Amarnath, Chilcott, Helen, Clarke, Samantha, Cobos-Arrivabene, Marta, Corderoy, Helen, Cousins, Rebecca, Garner, Victoria, Gillatt, David, Herbert, Chris, Johnson, Lyndsey, Jones, Kathryn, Kemp, Gail, Kirkby, Sarah, Kirkpatrick, Suriya, Koupparis, Anthony, Manning, Courtney, Oxley, Jon, Perry, Emily, Persad, Raj, Phipps, Charlotte, Richmond-Russell, Kerry, Rowe, Edward, Shelton, Luke, Shiridzinomwa, Constance, Smith, Carolyn, Treasure, Ann, Wilson, Paula, Wyatt, Clare, Beesley, Katherine, Benson, Richard, Couch, Ellie, Foxwell, Sue, Goss, Vanessa, Harnwell, Juliette, Hughes-Davies, Luke, Joslin, Vicky, Laubscher, Angelique, Mazhar, Danish, Patterson, Helen, Raj, Sanjay, Ramanujachar, Ramya, Rimmer, Yvonne, Robinson, Nicola, Russell, Simon, Stone, Matthew, Thomas, Robert, Treeby, Jo, Vickery, Kathryn, Woodward, Cathryn, Ahmed, Ilyas, Appleby, Bonny, Brulinski, Patryk, Buckley, Julie, Catt, Natalie, Coppins, Helen, Crawford, Sister Denise, Davies, Julie-Ann, Drakeley, Susan, Edwards, Albert, Evans, Clary, Galante, Joao, Gladwell, Louise, Gough, Jessica, Hargreaves, Carolyn, Hegarty, Gemma, Kehoe, Laura, Larkins, Rachel, Lipsham, Margaret, Little, Jessica, Malde, Rohit, Middleton, Sharon, Mikropoulos, Christos, Mirza, Arafat, Mithal, Natasha, Nathan, Kannon, Raman, Rakesh, Rendall, Alice, Robinson, Karen, Ryan, Rachel, Sim, Van, Swann, Michelle, Tasker, Lorraine, Taylor, Katy, Thomas, Carys, Trigonis, Ioannis, Walker, Karen, Williams, Joanne, Williamson, Elizabeth, Wood, Marian, Wood, Pauline, Zurakovsky, Hilary, Bois (nee Harris), Elizabeth, Chan, Hin Fan, Chikopela, Loveness, Clark, Helen, Clements, Colette, Holliday, Samantha, Hughes, Owen, Jones, Clare, Kynaston, Howard, Mason, Malcolm, Narahari, Krishna, Pearse, Kevin, Staffurth, John, Austin, Mandy, Barnett, Christian, Camburn, Sister Tracey, Dawson, Elizabeth, Gibson, Sian, Hamid, Abdel, Kancherla, Kiran, Leone, Priscilla, Perkins, Lauren, Ramsay, Valerie, Singizi, Bryan, Allen, Julie, Anderson, Susan, Andrews (nee Moore), Eleanor, Bakawala, Rehana, Beazer, Sarah, Binks, Colin, Bowen, Jo, Broomfield, Barbara, Cook, Audrey, Crossley, Lin, Ford, Chris, Forkes, Janet, Hall, Julia, Healey-Mariano, Jennifer, Jenkins, Peter, Johnson, Nigel, Jonnada, Sai, Owen, Roger, Pratten, Elaine, Sayers, Rachel, Shimell, Chris, Skelton, Amy, Tan, Matthew, Trigg-Hogarth, Kate, Wronski, Sue, Aldous, Mary, Archer, Denise, Eccleson, Helen, Gallimore, Elizabeth, Green, Sue, Ibrahim, Azman, Jones, Carys, Prince, Jude, Chrystal, Melanie, Din, Omar, Firth, Alexandra, Ford, Nicky, Kirkbride, Peter, Martindale, John, Redfearn, Alison, Smedley (nee McCabe), Janine, Smith, Lucy, Sorice, Vittoria, Stevenson, Lesley, Toms, Julie, Wood, Sister Kim, Barke, Nyssa, Basu, Devy, Dewar, Lorna, Driscoll, Celine, Hunting, Liz, Kumar, Muthar, Leone, Priscilla, Mabelin, Louies, Muthu Kumar, Dakshinamoorthy, Sizer, Bruce, Thorogood, Lucy, Askew, Sarah, Beech, Darren, Broom, Jane, Duley, Emma, Firth, Elizabeth, Gould, Aaron, Hocking, Christopher, Johns, Louise, Kent, Emma, Madine, John, Partridge, Kerena, Penhaligon, Corrine, Pentecost, Catherine, Pollard, Kay, Poultney, Melissa, Pynsent, William, Skewes, Johanna, Steele, Anita, Thomson, Alastair H, Topps, Alice, Townley, Luke, Wheatley, Duncan, Brown, Maggie, Chan, Andrew, Connor, Marie, Elwell, Sue, Geraghty, Kerry, Griffiths, Theresa, Hayward, Lesley, Humber, Caroline, Khan, Yakhub, Lake, Sister Judith, Laverick, Rosaleen, Mansell, Gemma, Mislang, Albert, Ngwenya, Su, Panesar, Pritpal, Sanders, Kay, Simmons, Elaine, Sinfield, Melanie, Stanley, Laura, Steventon, Emily, Stockdale, Andrew, Sunny, Manju, Thind, Manreet, Tranter, Fiona, Tsalic, Medy, Worlding, Jane, Adamson, Vanessa, Bennion, Carole, Butler-Barnes, Jenny, Hough, Adele, Hough, Chris, Hughes, Joanne, Irwin, P, Javle, P, Logue, John, Mansfield, Carolyn, Smith, Rachel, Sumner, Lesley, Tomlinson, Annabel, Tran, Anna, Walker, Caroline, Wylie, James, Chakraborti, Prabir, Das, Prantik, Ennis, Dawn, Marriott, Sue, Pattu, Pugazhenthi, Ward, Colin, Alzouebi, Mymoona, Burlace, Barbara, Ferguson, Catherine, Firth, Alexandra, Hooton, Georgia, Jeffcutt, Nicole, Martindale, John, Neal, Amy, Pezaro, Carmel, Sivoglo, Virgil, Smedley (nee McCabe), Janine, Smith, Lucy, Taylor, Jennifer, Wilkinson, Nicola, Wood, Sister Kim, Afzal, Naveed, Anderson, Beverley, Andrews, Stephen, Bakker, Piet, Breakspear, Sally, Cornaby, Andrew, Crellin, Perric, Gibbins, Andrew, Gibbins, Jackie, Glen, Tracy, Goodsell, Josie, Horton, Sarah, Jones, Stephanie, Love, Sally, Masters, Benjamin, Rees, Andrew, Sharpe, Simon, Taylor, Kate, Wignall, Suzy, Harrow, Sister Kath, Jones, Lesley, Kanyi, Karen, Keng-Koh, Pek, McGarry, Karen, Ramachandra, Prakash, Smith, Lucy, Watts, Angela, Baumber, Shelley, Gilbert, Duncan, Howard, Joanna, Jones-Skipper, Kay, Manetta, Caroline, McCrisken, Lauren, McKinna, Fiona, Taylor, Jo-Anne, Williams, Amanda, Clark, Alison, Clarke, Maria, Egan, Lisa, Fiddes, Kathleen, Forman, Susan, Gardiner, Fiona, Jeffrey, David, Mariappan, Param, Mayne, Barbara, McLaren, Duncan, Rogers, Brian, Woods, Catherine, Young, Douglas, Anderson, John, Baines, Kizzy, Crundwell, M, Davey, Elizabeth, Ford, Victoria, Lawless, Theresa, Matkins, Ellen, McGinley, Shannon, McGrath, John, Piper, Jane, Roantree, Alison, Seath, Ingrid, Sheehan, Denise, Srinivasan, Rajaguru, Stott, Mark, Timmings, Katie, Webb, Claire, Al-hasso, Abdulla, Allan, Elaine, Barwell, Lorraine, Cowan, Chloe, Dodds, David, Finnegan, Niall, Griffen, Ailsa, Jones, Rob, Lawless, Claire, MacMillan, Antonia, Mahmood, Rana, Russell, Martin, Sadozye, Azmat, Shirley, Sian, Sidek, Norma, Wallace, Jan, Akhtar, Naeem, Al-hasso, Abdulla, Ansari, Jawaher, Bell, Karen, Humpreys, Louise, McWilliam, Donna, Moody, Emma, O'Neil, Rebecca, Peck, Suzannah, Turley, Claudia, Auladin, Raidah, Bird, Stephanie, Bissa, Caterina, Dabbs, Marianne, Di Maria, Fabio, Goh, Chee, Guerrero-Urbano, Teresa, Harding, Joshua, Jamieson, Ceri, Jones, Jules, Khaksar, Sara, Laing, Robert, Matthews, Laura, Medisetti, Aruna, Molony-Oates, Barbara, Money-Kyrle, Julian, Nobes, Jenny, Rabsztyn, Weronika, Shaffer, Richard, Sidi, Frances, Smale, Daisy May, Stone, Sarah, Tindall, Annie, Woods, Jane, Wu, Min, Daniel, Amelia, Holmes, Evelyn, Kellaway, Joanne, Lewis, Amanda, Light, Teresa, Melcher, Lucinda, Robinson, Lily, Staines, Nikki, Anderson, Susan, Carini, Serrafina, Cook, Audrey, Cooper, Sophie, Evans, Melanie, Follows, Josh, Forkes, Janet, Grant, Warren, Hedges, Andy, Hughes, Claire, Jones (Birch), Janine, King, Lisa, Lees, Laura, Mercer, Lily, Myles, Sophie, Roberts, Zara, Williamson, Nicola, Abbassi, Sara, Alonzi, Roberto, Anyamene, Nicola, Bici, Julia, Collins, Lucy, Dickson, Jeanette, Garrido-Perez, Sandra, Hoskin, Peter, Hughes, Robert, Jenkins, Suzanne, Kowalewska, Paulina, Milner, Jessica, Mitchell, Lesley, Ostler, Peter, Rashid, Aamna, Stapleton, Stephanie, Bashir, Faheem, Bone, Linzi, Clark, Diane, Dixit, Sanjay, Horne, Rhian, Jones, Dawn, Palmer, Sarah, Plowman, Kristian, Rawlings, Julie, Simms, Matthew, Addison, Anglise, Arnott, Seonaid, Borgaonkar, Sudhir, Brown, Sandra, Campbell, Audrey, Colligan, Steve, Cormack, Margaret, Doughty, Victoria, Kelly, Kay, Lister, Debbie, Macdonald, Alison, Macgregor, Carol, Mackay, Rachel, Madeleine, Jude, McNally, Morag, McPhail, Neil, Neville, Sean, Nicholls, Alison, Papakostidi, Aristoula, Simpson, Georgina, Sinclair, Glenda, Skene, Anna, Telfer, Sheena, Urquhart, Zoe, Whillis, David, Etheridge, Charlotte, Ford, Amanda, Ridley, Paul, Scrase, Christopher, Upson, Susan, Venkitaraman, Ramachandran, Capaldi, Lisa, Churn, Mark, Higgins, Linda, Knott, Helen, Stringer (pr. Davis), Sally, Taylor, Jacob, Tranter, Helen, Wollaston, Julie, Brogan (nee Roddie), Stephanie, Erskine, Susan, Hamill, Maureen, Prentice, Lynn, Russell, Martin, Sidek, Norma, Symon, Lesley, Teahan, Seamus, Todd, Anne, Tweedle, James, Young, Sally, Austin (nee Glover), Gemma, Boon, Ian, Bottomley, David, Breckin, Edmund, Clarke, Jude, Coyle, Catherine, Davies, Emily, Goulding, James, Henry, Ann, Kiltie, Anne, Loughrey, Carmel, Moore, Eleanor, Murad, Fatima, Pratt, Claire, Shuttleworth, Pam, Smith, Beccy, Smith, Gill, Branson (née Dineen), Amy, Christmas, Sallyanne, Cooke, Jill, Griffiths, Leyshon, Kent, Christopher, King, Amy, Kockelbergh, Roger, Potterton, Janet, Speed, Lesley, Vasanthan, Subramanian, Walker, Julia, Archer, Simon, Baria, Karin, Bateman, Samantha, Coombs, Sarah, Cunningham, Amy, Dahar, Nazeer, Daruwala, Pallon, Francis, Olesya, Ginnelly, Helen, Hall, Jane, Hoare, Kathryn, Key, Claire, Lockwood, Carol, Mark, Ian, Newton, Rachel, Okubanjo, Maryanne, Panades, Miguel, Sloan, Andrew, Sreenivasan, Thiagarajan, Bermingham, Nicola, Dean, Lynsey, Malik, Zafar, Pilkington, Pauline, Robson, Peter, Rogers, Heather, Rogers, Thomas, Treherne, Katy, Bourke, Amie, Chikkamuniyappa, Bindu, Dalton-Short, Ross, Edwards, Steve, Falconer, Alison, Ford, Amy, Harinarayanan, Sathish, Hassan, Nebah, Hornzee, Gillian, Magwaro, Sophia, McInerney, Sue, Pratap, Bhavesh, Rezkallah, Sarah, Sadare (Olaleye), Ibiyemi, Stancliffe, May, Stewart, Simon, Thoi, Anne-Maree, Westrop, Anna, Ahamadali, Sheefa, Arsanious, Nasr, Balogun, Shaki, Batish, Cheryl, Campbell, Yvonne, Crowley, Claire, Dunne, Emma, Ferreira, Miguel, Haldeos, Anne, Hijab, Adham, Huddart, Robert, John, Babbin, Michaelidou, Andriana, Nawrozzadeh, Mohammed, Pach, Jackie, Patel, Priyanka, Payne, Ann, Perry, Matthew, Sadare (Olaleye), Ibiyemi, Serra, Maria, Springall, Christine, Thompson, Jane, Thomson, Sister Jane, Tree, Alison, Aya, Viviana, Beaney, Ronald, Bower, Lorna, Conway, Lisa-Jane, Donaghey, Sally, Gordon, Hussain, Grau, Isabel, Guerrero-Urbano, Teresa, Harris, Sarah, Hogan, Vesna, Hore, Brendan, Hughes, Simon, Jones, Katie, Kuenzig, Greg, Morris, Stephen, Nathan, Kannon, Nunney, Dawn, Rashid, Jessica, Reynolds, Philip, Rooprai, Bali, Chikkamuniyappa, Bindu, Dalton-Short, Ross, Edwards, Steve, Hassan, Nebah, Magwaro, Sophia, Mangar, Stephen, Rezkallah, Sarah, Stewart, Simon, Thoi, Anne-Maree, Westrop, Anna, Azirar, Hanna, Caumont, Tom, Gupta, Nishi, Hill, Judy, Karp, Stephen, Kullane, Sagal, Macavoy, Tina, Melcher, Lucinda, Neave, Farhad, Newby, Jackie, Van Someren, Chloe, Anderson, Naomi, Annan, Lynda, Cooke, Juniebel, Douch, Emma, Fawcitt, Sara, Gore, Alexandra, Grieve, Sylvia, Jarvis, Claire, McCadden, Angela, Needleman, Sarah, Pigott, Katherine, Powell, Hannah, Ramtohul, Kaliyanee, Rosenfelder, Nicola, Vilarino-Varela, Maria, Ali, Jennyfa, Ali, Maryam, Banda, Laillah-Crystal, Bott, Trevor, Brown, Emmanuel, Bryant, Hanna, Carlino, Giulia, Grant, Cordelia, Hogan, Holly, Khoo, Vincent, Mojidra, Chintan, Montebello, Joseph, Morrison, Jennifer, Olabanji, Matthew, Pillai, Sijy, Siu, Bernard, Stafferton, Ruth, Storrs, Sarah, Townsend-Thorn, Debra, Tree, Alison, Van As, Nicholas, Vijayakumar, Vijitha, Welsh, Liam, Dearnaley, David, Gao, Annie, Horwich, Alan, Huddart, Robert, Lewington, Val, Marshall, John, Murphy, Louise, Parker, Chris, Venkitaraman, Ramachandran, Beaton, Kirsty, Bech-Nielsen, Nanette, Bolton, Olivia, Chetiyawardana, Samantha, Conibear, John, Dekaj, Fatjon, Hillman, Paul, Jayachandran, Resmi, Kaliski, Alexandre, Kiff, Janet, Nicholson, Alastair, Nixon, Jude, Oladimeji, Janet, Riches, Oscar, Smith, Dan, Tipples, Karen, Wells, Paula, Anderson, Chris, Daly, Deirdre, Dover, Serena, Gilmartin, Claire, Golden, Sophie, Gregg, Jane, Issa, Rami, Khoo, Vincent, Oni, Titilayo, Patel, Chandni, Perry, Matthew, Quarrell, Mark, Rolfe, Debbie, Tighe, Helen, Toledo, Jesusa, Tuazon, Juel, Varro, Robert, Bohra, Vikram, Caballes, Mark, Custins, Laura, Hornzee, Gillian, Ivie, Stephanie, Joshi, Manisha, Liau, Joy, Magwaro, Sophia, Naim, Farhan, Patel, Anup, Pathmanathan, Byiravey, Russell, Emily, Stewart, Simon, Thoi, Anne-Maree, Tippins, Anna, Westrop, Anna, Agdiran, Didem, Aggarwal, Ajay, Amoaten, Thomas, Aslam, Natasha, Bonsu, Nicole, Butt, Zainab, Danaswamy, Patricia, Davda, Reena, Gillesen, Annelies, Goel, Roshni, Hall, Julia, Khong, Rachel, Lowi, Suzy, Merrick, Richard, Mitra, Anita, Payne, Heather, Teh, Jonathan, Whinn, Samantha, Woolf, David, Zilkha, Helene, Bech-Nielsen, Nanette, Bolton, Olivia, Danaswamy, Patricia, Dawson-Athey, Linda, Foster, Emma, Gillian, Andrew, Green, James, Hillman, Paul, Hines, John, Holden, Simon, Jayachandran, Resmi, Kazingizi, Memory, O'Neill, John, Olaoni, Thompson, Peters, John, Philp, Timothy, Wells, Paula, Woolf, David, Zaidi, Sadaf, Adeyoju, Adebanji, Adinkra, Victoria, Brough, Richard, Brown, Stephen CW, Collins, Gerald, Hardstaff, Lisa, Hill, Pippa, Kujawa, Magda, McCurrie, Marilyn, Townley, Barbara, Woodhouse, Iain, Zafar, Waheed, Beesley, Sharon, Breen, Vivienne, Brulinski, Patryk, Burrage, Su, Calvert, Clare, Davison, Alison, Dias, Heather, Fossey, Gavin, Hotine, Jodie, Jones, Ifan, Jope, Carmel, Lines, Yvonne, Martins, Sarah, Mercier, Barbara, Mikropoulos, Christos, Murray, Jane, Neshiri, Innocent, Pamphlett, Ian, Phillips, Ann, Rai, Pavnish, Rezkallah, Sarah, Roberts, Verity, Taylor, Henry, Taylor, Katy, Thomas, Carys, Tribe, Lisa, Wood, Pauline, Bottomley, Ian, Buchan, Jonathan, Carpio, Viviana, Choudhury, Ananya, Conroy, Ruth, Cowan, Richard, Davison, Sue, Duncan, Ian, Elliott, Tony, Fair, Kim, Fallaize, Adrian, Flanagan, Laura, Green, Sarah, Harris, Catherine, Hart, Amber, Jones, Cathryn, Livsey, Jacqueline, Logue, John, McCaul, Damian, Nazari, Roonak, Newbery, Carol, O'Connor, Kate, O'Dwyer, Sister Jackie, Oliver, Joanne, Onoge, Ekugbe, Petsa, Maria, Redshaw, Catherine, Smith, Sarah-Ellen, Spoor, Willemijn, Thomas, Sister Viv, White, Holly, Worsley, Lucy, Wylie, James, Bailey, Linda, Bennett, Molly, Corless, Rebecca, Duffy, Annie, Fellows, Kathryn, Gipson, Anna, Haydock, Helen, Knox, WF, Liptrott, Sarah, McCarth, Fiona, McCartin, Fiona, Mistry, Heena, Mthethwa, Thobekile, Partington, Lillian, Piper, Lindsay, Ramani, Vijay, Sahin, Sarah, Sangar, Vijay, Slevin, Kathryn, Tuck, Jonathan, Wylie, James, Atkinson, Lorraine, Barnbrooke, Sarah, Barnes, Alison, Brownless, Caroline, Chadwick, David, Hardman, John, Harland, Keith, Long, Carol, McAuliffe, Sarah, McBride, Julia, McClurey, Sister Patricia, Mohan, Rita, Naylor, Lynne, Peedell, Clive, Robson, Paula, Shakespeare, Devadasan, Thompson, Emma, Van der Voet, Hans, Wilson, David, Barron, Chris, Frew, John, Lambert, Katy, McMenemin, Rhona, Pedley, Ian, Riseborough, Danielle, Roberts, Trevor, Stockley, Emma, Stoddart, Jonathan, Tate, Janine, Walker, Jayashree, Workman, Bridget, Barnett, Debra, Carter, Adam, Cox, Adam, Davey, Alison, Davies, Kirstin, Gilby, Lisa, Hodge, Simon, Kearney, S, Lavender, Helene, Marty, Janet, Nash, Maxine, Rahman, Syhed, Richards, Jayne, Simpson, Julie, Wall, Elaine, Webb, Paula, Wild, Karen, Williams, Rachel, Wilson, Jim, Branagan, Jenny, Camilleri, Philip, Dell, Gillian, Elwell, Christine, Foo, Maxine, Goyena, Ruby, Jones, Andrea, McBain, Hazel, McGrath, Katherine, O'Callaghan, Jane, Ramanathan, Dorai, Tee, Elizabeth, Thominson, Bronwen, Tighe (nee Bussey), Rachel, Archer, Denise, Beety, Jane, Birch, Richard, Bloomfield, Mark, Callam, Sara, Cooper, Adele, Darby, Helen, Healey, Gail, Heasley, Karen, Kapur, Guarav, London, Clare, Nobes, Jenny, Oosterom, Katrien, Ostrowski, Joe, Shobrook, Bridget, Turner, Sarah, Wade, Rob, Walker, Suzanne, Walton, Sharon, Websdale, Cheryl, White, Joanna, Alder, Leanne, Chivers, Rachael, Gooch, Carol, Howard, Lucy, Hutchinson, Camille, Jevons, Cody, Kumar, Daniel, Marley, Hazel, Mills, Jamie, Purves, Hanna, Sayers, Ian, Sundar, Santhanam, Szolin-Jones, Jacob, Walker, Georgina, Wood, Catherine, Choudhury, Ananya, Conroy, Ruth, Cook, Wendy, Gill, Lisa, Johnson, Joanne, Johnstone, Dawn, Jones, Richard, Livsey, Jacqueline, Mistry, Leena, Scarratt, Lyndsay, Aiku, Abimbola, Ajzensztejn, Daniel, Al-Chamali, Hiba, Andrade, Gerard, Barber, Dave, Bekulart, Sylwia, Bhatnagar, Gagan, Boutflower, Jane, Brewster, Simon, Butterfield, Anne, Camilleri, Philip, Carroll, Weronika, Cole, David J, Coutts, Tim, Doyle, Kerrie, Durrant, Lisa, Green, Trish, Hyde, Katherine, Jampana, Raj, Jastrzebska, Patrycja, Kiltie, Anne, Kyffin, Phillippa, Langridge, Nicole, Lawrey, Sarah, Markus, Sarah, Marston, Kerrie, Mooney, Matthew, Mukkath, Sandra, Murphy, Ann, Owens, Rob, Panakis, Niki, Rabsztyn, Weronika, Ruane, Sarah, Sabbagh, Ahmad, Sabharwal, Ami, Samkange, Grace, Sankighatta, Naveen, Skwarski, Michael, Stuart, Robert, Wellman, Sandie, Wilson, Jo, Cavanagh, Kerrie, Hollingdale, Abigail, Allen, Susan, Barter, Elisa, Benson, Richard, Gregory, Debbie, Ingle, Charlotte, Lawrence, Steph, Rooney, Paula-Joanne, Bishop, Emma, Brennan, Maria, Cogley, Lyn, Hammonds, John Christopher, McInerney, Paul, McLarty, Esther, Natale, Salvatore, Pascoe, Sarah, Purcell, Keith, Sells, Henry, Tyner, Sharah, yates, Victoria, Beamish, Neal, Blaney, Hilary, Brock, Sue, Clapp, Felicity, Clarke, Elizabeth, Coffin, Teresa, Crellin, Perric, Davies, Joe, Downs, Nichola, Gillespie, Sally, Goodsell, Josie, Harinarayanan, Sathish, Heckford, Louise, Iskender, Amanda, Orford, Sara, Pressdee, Sandy, Rix, Sophie, Wheelwright, Roger, Woodward, Elizabeth, Wright, Seonaid, Blight, Kathy, Dobson, Tracey, Hale, Jennifer, Harris-Burland, Angie, Khoury, Ghassan, Madhava, Kudingila, Meadows, Lorna, Nagar, Yoodhvir, Roca, Mila, Stacey, Wendy, Stephenson, Anna, Uherek, Maja, Virgo, Azarel, Watkinson, Catrin, Birtle, Alison, Chauhan, Zainab, Cornthwaite, Stephanie, Curtis, Sandra, Ellard, Rose, Fish, Nathan, Hefferon, Billy, Parikh, Omi, Searle, Claire, Spickett, Helen, Walmsley, Catherine, Wise, Marcus, Atkinson, Jane, Brown, Richard B, Cartwright, Debbie, Coomber, Kristy, Hunt, Allison, Kowalczyk-Williams, Wioletta, Lewis, Christina, Parr, Stephen, Purdon, Helen, Rogers, Paul, Vowell, Emma, Capaldi, Lisa, Featherstone, Wendy, Hamilton, Joanna, Harrison, Alison, Hindle, Margaret, Hodson, Hayley, Isaew, Andrea, Knapp, Jeanette, Moss, Sarah, Gibbs, Stephanie, Gujral, Sandeep, Jannapureddy, Revanth, Kelkar, Anand, Martinou, Maria, Mills-Baldock, Tina, Nicholson, Alastair, O'Brien, Neale, Subramaniam, Ramachandran, Tahir, Saad, Vandal, Mohammad Tanvir, Vu, Thi, Allen, Rachael, Betts, Chris, Bowmer, Amanda, Clarke, Noel, Cordwell, Amanda, Cowan, Richard, Dharmaprasad, Soney, Duncan (nee Keatley), Claire, Elliott, Tony, Farnworth, Christine, Farrell, Helen, George, Siny, Goulden, Kay, Harter, Leah, Kaushal, Malan, Kirk, Sister Sarah, Lau, Maurice, Lydon, Anne Marie, O'Flynn, Kieran, Platt, Danielle, Redshaw, Catherine, Richardson, Karen, Shackley, David, Stevenson, Garry, Taylor, Sister Melanie, Thompson, Chloe-Anne, Tran, Anna, Vinod, Cellins, Wadsworth, Oliver, Youd, Sister Jill, Attlee, Julie, Bhatnagar, Adityanarayan, Bunn, Sarah, Campbell, Allister, El-Saghir, Mohammed, Fennelly, Ruth, Guy, Peter, Gwilt, Julie, Mattocks, Lehentha, Mcintosh, Gregor, Murphy, Brenda, Reed, Catherine, Strong-Sheldrake, Sophia, Tedd, Gemma, Dent, Kathleen, Dixit, Sanjay, Hood, Marion, Martin, Karen, Pearson, Sandra, Potoczna, Dorota, Spencer, Sue, Towse, Jo, Whotton, Nikita, Bowen, Katie, Clark, Su, Clarke, Rachael, Ferguson, Catherine, Firth, Alexandra, Gibbins, Kate, Kirkbride, Peter, Martin, Jackie, Martindale, John, Smedley (nee McCabe), Janine, Smith, Suzanne, Spalton, Catherine, Tay, Jessica, Wood, Sister Kim, Adams, Marion, Bates, Emma, Chennattukungu, Indukala, Clancy, Joanna, Cross, Vanessa, Hughes, Hayley, Jose, Sanal, Kurian-Downer, Sunita, Michael, Elena, Moore, Sister Helen, Nicholas, Karen, Pope, Suzanne, Potts, Sally, Prashant, Ravi, Singh, Harpreet, Smith, Sandra, Srihari, Narayanan, Weaver, Emma, Abbas, Ali, Barnes, Nicky, Brown, Richard B, Dallas, Nicola, Jackson, Sister Ann, Kader, Nicole, Karim, Omer, Laniado, M, Litchfield, Jayne, Mahmood, Sana, O'Donnell, Helen, Robinson, Victoria, Sears, Alison, Sharif, Shahid, Sierra Pala, Ana, Sinclair, Julie-Ann, Smith, Sister Catherine, Ashcroft, Jan, Boardman, John, Bowes-Cavanagh, Jeanette, Brown, Rebecca, Chedham, Alison, Darch, Flora, Farrar, Michelle, Foot, Jayne, Goldsworthy, Simon, Graham, John, Gray, Emma, Green, Sara, Jelski, Joseph, Kalejaiye, Odunayo, Keni, Manjusha, Locke, Angela, Mahoney, Sue, McMeekin, Faith, Periasamy, Manivannan, Russell, Tamlyn, Ruszala, Elizabeth, Segaran, Surayne, Tighe, Mary, Varughese, Mohini, Wallbutton, Rebecca, Webster, Christine, Whitcher, Alison, Wiggins, Sarah, Wrigley, Martha, Zietz, Maria, Abab, Julie, Cumming, Kirsty, Galloway, Lucy, Ganabady, Malavika, Gwilt, Julie, Haskell, Annelise, Heath, Catherine, James, Naomi, Kennedy, Julie, McFarlane, Victoria, Morales-Azofra, Fabiola, Morton, Susan, Mundy, Carina, Noble, Mark, Paschalis, Alec, Patrick, Julie, Reader, Leanne, Stephenson, Anna, Taylor, Lisa, Wakefield, Shauna, Ahmed, Imtiaz, Bowman, Sue, Chan, Olivia, Cyriac, Abby, Davies, Tracey, Maitland, Katrina, Prejbisz, Jan, Reece, Sheila, Shires, Heather, Tsang, David, Anscombe, Eleanor, Brough, Richard, Brough, WA, Clitheroe, Pat, Cocks, Tracie, Collins, Gerald, Connolly nee McKenna, Sarah, Corcoran, Sam, Coughlan, Tricia, Gilmour, Christina, Goodwin, Emma, Graham, Susan, Hatimy, Umi, Haydock, Helen, Hodgkinson, Sheila, Kilmartin, John, Logue, John, Orrell, Lucy, Rotherham, Carol, Smallwood, Sarah, Taylor, Jill, Wiss, Elliott, Adab, Fawzi, Bhana, Rajanee, Dhinakaran, Kathirvelu, Evans, Marion, Myatt, Alison, Parkinson, Katrina, Peake, Angela, Sellars, Elizabeth, Smith, Rowena, Storer, Julie, Thomasson, Georgia, Vengalil, Salil, Walton, Jenny, Ward, Angela, Boam, Samantha, Burgoyne, Jamie-Rae, Chadwick, Eliot, Gill, Shafiq, Haigh, Steve, Hollis, Keri, Lim, Jun, McCabe, Alastair, Munson, Lyndsey, Nash, Dominic, Saunders, Daniel, Smith, Susan, Sundar, Santhanam, Wade, Lynne, Walker, Georgina, Evans, Elizabeth, Franklin, Alex, Harris (n. Marchant), Emily, Johnstone, Maria, Jones, Lewis, Lemon, Nicola, Phan, Mau-Don, Pudney, Delia, Spence, Rachael, Stretch, Alison, Tait, Ellen, Williams, Bethan, Belcher, Rebecca, Cole, David J, De Silva-Minor, Shiroma, Dodge, Sister Jan, Grayland, Sarah, Jones, Ania, Khan, Omar, Owen, Tim, Palmer, Debbie, Parajes, Cerila, Pegler, Suzannah, Poole, Abbie, Sargent, Sister Tracey, Starling, Ellen, Taylor, Becky, Winter, Sister Helen, Zinyemba, Vivian, Allison, Michele, Blundell, Martyn, Brookman, Catherine, Buckley, Jon, Chamberlain, Shelley, Cuffe, Donna, Davies, Stacey, Fairfax, Claire, Greedus, Helen, Griffin, Hannah, Koehler, Ingrid, Lydon, Anna, Michels, Jorg, Pym, Julia, Roberts, Fiona, Srinivasan, Rajaguru, Thornton, Lorraine, Vandecandalaere, Elaine, Watts, Erica, Welsh, Linda, Anderson, Jim, Anderson, Juliette, Ball, Julie, Benton, Louise, Bowers, Richard, Burlace, Barbara, Casanova, Nathalie, Chahal, Rohit, Coyle, Catherine, Dickinson, Peter, Fosker, Chris, Heeley, Janine, Henry, Ann, Kanaga-Sundaram, Subramanian, Littler, Stephen, Rodda, Sree, Slack, Jonathan, Sundaram, Subramanian Kanaga, Taylor, Beverley, Weston, Philip, Chan, Andrew, Chettle, Judith, Gamble, Tina, Griffiths, Theresa, Hartwell, Lyn, Johnson-Rollings, Ashley, Jones, Julia, Millage, Helen, O'Neill, Eilish, Simmons, Elaine, Stockdale, Andrew, Walsh, Donna, Webb, Kerrie, Williams, Jo, Anderson, John, Dymond, Harvey, Eleftheriadis, Symeon, Hilman, Serena, Lloyd-Jones, Hugh, Wells, Tom, Bennett, Sarah, Dunn, Sharon, Fildes, Diane, Hassall, Alison, Herbert, Gaynor, Hughes, Kathryn, Innes, Helen, Kelly, Alison, Littler, John, Lomax, Laurie, Miller, Nikki, Nutman, Chris, Stott, Matthew, Syndikus, Isabel, Tolan, Shaun, Weston, Alison, Baker, Ivanna, Carter, Vanda, Chatfield, Jenny, Churn, Mark, Cooke, Peter, Grant, Anna, Homer, David, Keng-Koh, Pek, Kirk, Christine, Lomas, Claire, McCormick, Marian, Mohseeni, Arizoo, Pawaroo, Renita, Radford, Liz, Rogers, Jason, Samanci, Ali, Sayers, Ian, Sharman, Emma, Spencer, Hazel, Spruce, Debbie, Worthington, Hannah, Bak, Dagmara, Bowen, Jo, Capaldi, Lisa, Cleary, Kristy, Davies, Sue, Forkes, Janet, Gauntlett, Monica, Gupta, Kamalnayan, Healey-Mariano, Jennifer, Hodson, Hayley, Holdsworth, Amanda, Ledger, Kate, Morrow, Hugh, Perry, Heather, Rimell, Patricia, Rosoman, Alison, Taylor, Jacob, Tranter, Helen, Tyler, Jayne, White, Ann, Bloomfield, David, Crowe (nee Hughes), Dawn, Flynn-Batham, Marian, Folkes, Linda, Funnell, Sarah, Gilbert, Jeanette, Gomez-Marcos, Raquel, Gonzalez, Celia, Hoskins, Chloe, Moore, Sally, Nikapota, Ashok, Plataniotis, George, Rippin, Sarah, Smith, Matthew, Tsawayo, Tan, Turner, Nikki, Wakelen, Paula, Brady, Joanne, Camilleri, Philip, Carpenter, Janice, Cserbane, Anita, Fernandez, Claire, Hogbin, Emma, Hyde, Katherine, Joshi, Manisha, Kavanagh, Roisin, Kurup, Rahul, Manyangadze, Sarah, McLain-Smith, Susan, Ngumo, Alice, Panakis, Niki, Protheroe, Andrew, Pwint, Thinn, Sabharwal, Ami, Trewsmith, Neil, Wynn, Hazel, Allison, Joanna, Barron, Claire, Beaumont, Erica, Beer, Nigel, Beesley, Kate, Donaldson, David, Duckett, Tracey, Fox, Shirley, Gray, Emma, Kotze, Michelle, Kumar, Shiyam, Macrory, Joanne, Perry, Jess, Pippard, Lucy, Porter, Tim, Rennie, Kerry, Sparrow, Geoffrey, Williams-Yesson, Barbara, Balderson, Jane, Bottomley, David, Bowling, Lorna, Brittain, Paul, Brookes, Claire, Campbell, Hilary, Campos, Monica, Conway, Rachel, Davies, Flor, Donnison, Michelle, Elliott, Mark, Evans, Richard, Fallah, Fereshteh, Fearnley, Mark, Giddings, Emma, Gollapothu, Srilakshmi, Harvey, Sally, Holbrook, Andy, Howard, Lucy, Ingham, Jo, Jakeman, Christine, Joseph, Joji, Mole, Lisa, Musunuru, Hima Bindu, Pashley, Sarah, Saleem, Shamila, Stower, Michael, Strider, Paula, Taylor, Carol, Thackray, Louis, Todd, Joanna, Wightman, John, Wilson, Russ, Youngs, Nora, Byrne, Mary Marg, Deenihan, Emma, Durkan, Garret, Jennings, Marian, Mahoney, Catriona, Martin, Joseph, McInerney, Veronica, Raftery, Liz, Rogers, Eamonn, Spillane, Maria, Sullivan, Frank, Teh, Chiaw Woon, Wright, Ann, Harving, Niels, Hejlesen, Finn, Kempel, Mette Moe, Steffensen, Kirsten, Bentzen, Lise, Borre, Michael, Buus, Simon, Fode, Kirsten, Kaa Bach, Birgit, Lassen, Yasmin, Laursen, Vibeke, Lemng Kruse, Helle, Lucakova, Slavka, Nørmark Iversen, Helle, Brasso, Klaus, Christensen, Anne Juel, Gruschy, Lisa, Klovgaard, Karina, Lunau, Anne Sofie, Meidhal Petersen, Peter, Moller Christensen, Trine, Poder, Lone Lund, Ribers, Kristine, Stilling, Sine, Thim, Stine, Torin Lehmann, Anna, Vandborg, Maria, Christensen, Tine, Kokholm, Kathrine Friser, Lindberg, Henriette, Nybom, Kirstine, Rønnengart, Eva, Saxe, Charlotte, Baird, Noelle, Braun, Michael W, Cheung, Arthur, Fourt, Monica, Jackson, Cathy, Jepson, Debbie, Johnson, Arlissa, Karvat, Anand, Kwan, Winkle, McIndoe, Sue, Mitchell, Donna, Sandhu, Sandeep, Serpanchy, Rosanne, Wu, Helen, Beausoleil, Rachelle, Crawford, Melanie, DiMarco, Christine, Ding, Ian, Gladwish, Adam, MacIsaac, Patricia, MarshGray, Kimberley, Morton, Gerard, Murphy, Cara, Pascoe, Caitlin, Pokhrel, Sujata, Stevens, Christiaan, Yoon, Frederick, Yu, Jason, Dubey, Arbind, Sivananthan, Gokulan, Bahary, JeanPaul, Barkati, Maroie, Beauchemin, MarieClaude, Benth, Silvine, Carbonaro, Adriana, Delouya, Guila, ElSokhn, Nidale, Frazzi, Alexandra, Lambert, Carole, Lavertu, Sophie, Menard, Cynthia, Pan, Siew Siew, Rousseau, Pierre, Saad, Fred, Taussky, Daniel, Trudel, Diane, Amanie, John Oliver, Batz, Margaret, Borynec, Carol, Danielson, Brita, Garcia, Leni Santiago, Gramlich, Colin, Lang, Monika, Larson, Beverly, Mallett, Debbie, McCrudden, Sylvia, Murtha, Albert, Parker, Shelley, Parliament, Matthew B, Patel, Samir, Pearcey, Robert, Pervez, Nadeem, Rose, Jim, Shewchuk, Caroline, Smith, Carlie, Usmani, Nawaid, Williams, Candra, Yee, Don, AlRashdan, Abdulla, Avery, Alison, Beaton, Heather, Bond, Brittany, BrucePayne, Kim, Burbridge, Susan, Bursey, Kara, Carvery, Lane, Dill, Kendra, Dugas, Stevie, Harding, Claudia, Hodder, June, Hollenhorst, Helmut, Hubley, Lynn, Joseph, Paul K, Little, Erin, MacDonald, Angela, MacIsaac, Kathy, MacVicar, Jennifer, McCracken, Jillian, Moffatt, Emily, Nieforth, Joan, Patil, Nikhilesh, Rijt, Kelsey van der, Roberts, Victoria, Rose, Tina, Rutledge, Robert DH, Salyzyn, Camryn, Simpson, Robin, Sutherland, Donna, Walker, Heather, Wilke, Derek, Yeo, Tanya, Yunace, Lorrie, Zinck, Connie, Bier, Bianca, Bucci, Catherine, Corbett, Thomas B, Dayes, Ian S, Eady, Robin, Gudelis, Susan O, Hill, Elaine, Kinrade, Yvonne, Laughlin, Anne, Lukka, Himu, Makepeace, Barbara, Marshall, Lynn, Nielsen, Linda, Oliverio, Carmela, Patel, Malti Behn, Tsakirdis, Thedoros, Wong, Jason W T, Allen, Kirsten, Bachand, Francois, Carefoot, Layton, Cotts, Shannon, Creelman, Brianna, Crook, Juanita, GeorgeChayka, Danielle, Halperin, Ross, Hartt, Nancy, Hayes, Jill A, Kim, David, Kim, TuongVan, Kronstal, Flo, Lee, Bernard, Lew, Tanya, McClelland, Marie, Opitz, Debbie, Overend, Aldyn, Reed, Melanie, Watson, Michaella, Wilkie, Karen, Winn, Carol, Yanchuk, Janet, Bonner, Scott, Brander, Mike, Brundage, Michael, Carlson, Cindy, Edwards, Jackie, ElKerdawy, Hala, Harpell, Rhonda, Hartman, Carrie, Kalyvas, Maria, KirbyBello, Denise, Kumar, Vikaash, Leach, Deborah, MacVicar, Karen, Mahmud, Aamer, Maize, Christine, Moelker, Yvonne, Murano, Abby, Paul, Nancy, Ross, Ashley, RossSmith, Marleen, Shenfield, Carey, Spencer, Craig, Tennant, Virginia, Vermette, Tracy, Willing, Stephanie, Zaza, Khaled O, Zeltser, Fred, Gearing, Jennifer, Girolametto, Carla, Gopaul, Darindra, Hamilton, Ronald, Hendel, Debra, Janke, Susan, Knackstedt, Jochen, Kuk, Joda, Morrison, MaryBeth, Mumin, Anissa, Nemirov, Stephanie, Rachakonda, Ramana, Shantz, Brenda S, Siddiqui, Atif, Thallury, Sheeba, Ahmad, Belal, Bailey, Laura, Bauman, Glenn, Camara, Mary Jane, Corkery, Danylle, DSouza, David, DiLullo, Elenor, Eichenberger, Lois, Francis, Peggy, Grant, Susan, Gratton, Albert, Gurzanski, Christina, Hare, Jennifer A, Johnson, Craig, Kenny, Shannon, Lock, Michael I, Loughlin, Kate, Mardell, Stephen, Mayer, Heather, Rodrigues, George B, Sax, Lori, Sebborn, Kes, Sexton, Tracy, Venkatesan, Varagur M, tenHaaf, Darlene, Chatelain, AnneMarie, Fortin, Jacqueline, Houle, Stefanie, Khaouam, Nader, Lachance, Nicole, Laliberte, Benoit, Lemaire, Celine, Nguyen, David H A, Sylvestre, Alma, Vavassis, Peter, Yassa, Michael, Adnaan, Jamila, Briand, Wayne, Casey, Linda, Chipman, Penny, Corwin, Charlotte, Duclos, Marie, Faria, Sergio Luiz, Ghoul, Mokhtar, Joncas, MarieClaude, Koulouris, Zoe, Larocque, Stephanie, Lee, Brenda, Olha, Carolynna, Robert, MarieFrance, Sharma, Rajesh, Shenouda, George, Souhami, Luis, Albrecht, Virginia, Froese, Jane, Froude, Nancy, Howitt, Pamela, Iqbal, Fawaad, Kift, Shannon, Koll, Wayne, Li, Audrey, MacGregor, Barbara, Manganaro, Aileen, McKee, Dianne, Mendoza, Edeliza, Mui, Jimmy, Myrehaug, Sten, Singson, Angelina, Slessor, Janet, Somasiri, Ashane, Stevens, Nicole, Berghout, Koralee, Bourque, JeanMarc, Carkner, Amy, E, Choan, Eapen, Libni, Eze, Nancy, Fish, Matt, Haddad, Alain, Hicks, Kimberly, Iordanidi, Elina, Kanji, Femina, Kendal, Wayne S, MacMullin, Lisa, MacRae, Robert M, Malone, Shawn, Morgan, Scott, Nguyen, Julie, OBrien, Anna, Page, Nancy, Perry, Gad A, Reeves, MarieClaude, Roach, Joanne, Sanchez, Maria, Spearman, Mary, Spencer, Patti, Tikoo, Archana, Turriff, Lisa, Wright, Natalie, Bedoya, Luis Diaz de, Cossette, Danielle, Cusan, Leonello, Desrosiers, Isabelle, Dufour, Nathalie, Foster, William, Gomez, JoseLuis, Hathout, Lara, Lajoie, MarieAndree, Martin, AndreGuy, Pouliot, Sophie, Vigneault, Eric, Bouchard, Myriam, Bujold, Rachel, Carmel, Michel, Cote, Genevieve, Dion, Helene, Ebacher, Annie, Gauthier, Isabelle C, Ladouceur, Cynthia, Lamoureux, Alexandra, Larouche, Julie, Marquis, Tania, Nabid, Abdenour, Pearson, Diane, Sabbagh, Robert, TetreaultLaflamme, Audrey, Baker, Erin, Blackwood, Geoffrey, Galway, Denise, Greenland, Jonathan, Hannaford, Zeta, Hoskins, Ashley, House, Gail, Kamran, Asim, Manning, Kimberley, Nelder, Matthew, Noel, Lorilee, Norman, Alia, ODea, Jamie, Pinnell, Erin, Pochini, Craig, Putt, Dawne, Rahman, Arifur, Rickert, Lauren, Sathya, Jinka R, Teasdale, Breanne, Thoms, John, Whiteway, Chrystal, Whittle, Stacy, Cheung, Patrick CF, Chu, William, Chung, Hans T, Commisso, Angela, Danjoux, Cyril, Escueta, Vivette, Klotz, Laurence, Leung, Michael, Liu, Stanley, Loblaw, Douglas Andrew, Malek, Leila, Morton, Gerard, Nam, Robert K, Szumacher, Ewa, Tseng, Eric Chia Lin, Vesprini, Danny, Abed, Jessy, Ang, Daniel, Bayley, Andrew J, Berlin, Alejandro, Bristow, Robert, Catton, Charles, Chan, Heidi, Chui, Amadeus, Chung, Peter, Degendorfer, Sarah, Gospodarowicz, Mary, Gregorcic, Emily, Gumapac, Nicole, Helou, Joelle, Hsien, John, Kong, Vickie, Lalani, Nafisha, Lao, Bernadeth, Lawson, Daeria, Menard, Cynthia, Merante, Pat, Milosevic, Michael, Mirmooji, Ramesh, Muraj, Zaynab, Peres, Sarin, Petroff, Avi, Petrovska, Aleksandra, Pineda, Sandra, Quintos, Judy, Raman, Srinivas, Ramotar, Sarah, Ruiz, Maria Jose Gaitan, Sabate, Kathryn, Shukla, Arundhati, Tharahan, Nanthini, Thevarajah, Vaishaali, Tiessen, Kyoko, Topalovich, Aleksandra, Torres, Cynthia, Tse, Karen, Tsuji, Debbie, Velec, Erin, Wallace, Kris, Warde, Padraig, Bisson, MarieEve, Dahmane, Rafika, Gagne, Vanessa, Harvey, Julie, Lebrun, Benoit, Marineau, Line, Montour, Julie, Samson, Julie, Sicard, MarieEve, Thibeault, Andreanne, Vincent, Francois, Vincent, LindaSuzanne, Blood, Paul A, Canavan, Joycelin, Clements, Mia AnnaMaria, Glick, Daniel, Holloway, Caroline, Holwerda, Eleanor, Joe, Howard, Lacey, Cathy, Lam, Jacqueline, Leong, Nelson, Lim, Jan, Lomas, Alia, Pai, Howard H, Priestley, Emilie, Shahid, Negin, Vallieres, Isabelle, Duncan, Graeme, Gleave, Martin E, Goldenberg, S Larry, Karunakaran, Subashini, Keyes, Mira, KimSing, Charmaine, McKenzie, Michael, Morris, William James, Nakashima, Lynne, Peacock, Michael, Pickles, Thomas A, Rodda, Sree, Sibug, Sheena, So, Alan I, Tyldesley, Scott, Zhang, Tina Wanting, Ahmed, Shahida, Ammeter, Barb, Anderson, Leanne, Ann, Taehee, Bakija, Zeljka, Bashir, Bashir, Benjaminson, Patricia, Bergen, Leah, Cadiz, Lovely, Chahine, Jacqueline, Cherepak, Kathy, Chornopyski, Tracy, Chowdhury, Amitava D, Davies, Heather, Dawe, David, Drachenberg, Darrel E, DuMontier, Joelle, Dubey, Arbind, Eska, Tiffani, Francisco, Cristina, Gamez, Raquel, Garrett, Gina, Giovannini, Julia, Graham, Jeffrey, Guarino, Robyn, Hunter, William, Johnston, Laurel, Kitkowski, Caitlin, Klapp, Kathi, Koul, Rashmi, Kuzyk, Valerie, Last, Debbie, Li, KuanLin, Long, Heather, Majumdar, Arpita, Marek, Kathleen, McNish, Jennifer, Mills, Laurie, Morales, Maria, Nashed, Maged, Nichol, Rhonda, Ong, Aldrich Dixon, Ouelette, Ashley, Patel, DeepKumar, Pawl, Marilyn, Peak, Lisa, Priebe, Shauna, Quon, Harvey, Rizzuto, Stacey, Rudnicki, Rayleen, Santos, Priscilla, Sharma, Atul, Sivananthan, Gokulan, Squires, Mandy, Trakalo, Kathy, Turner, Christy, Vaughn, Jamie, Walker, Lori, Watson, Melanie R, Wei, Joyce, Weir, JoAnn, Woloshyn, Rose, Wood, Allison, Zhang, Hanbo, and Zwarych, Darlene

Abstract

Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain.

Published
2024
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39. Clinicopathologic factors that influence prognosis and survival outcomes in men with metastatic castration‐resistant prostate cancer treated with Radium‐223

Author

Esmail M. Al‐Ezzi, Husam A. Alqaisi, Marco A. J. Iafolla, Lisa Wang, Srikala S. Sridhar, Adrian G. Sacher, Nazanin Fallah‐Rad, Di M. Jiang, Geoffrey A. Watson, Charles N. Catton, Padraig R. Warde, Rob J. Hamilton, Neil E. Fleshner, Alexandre R. Zlotta, and Aaron R. Hansen

Subjects
clinical management, neoplasms, prognostic factors, prostate cancer, risk model, survival, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background In men with metastatic castration‐resistant prostate cancer (mCRPC) with primarily bone metastases, radium‐223 (223Ra) improves overall survival (OS). However, the selection of 223Ra is not guided by specific validated clinicopathologic factors, and thus outcomes are heterogeneous. Patients and methods This retrospective survival analysis was performed in men with mCRPC treated with 223Ra at our cancer center. Demographics and disease characteristics were collected. OS was calculated using the Kaplan–Meier method (log‐rank). The potential prognostic factors were determined using both univariable (UVA) and multivariable analysis (MVA) (Cox‐regression) methods. Results In total, 150 patients with a median age of 74 years (52–93) received 223Ra between May 2015 and July 2018, and 58% had 6–20 bone metastases. Ninety‐four (63%) patients received >4 223Ra doses, and 56 (37%) received ≤4. The following pre‐treatment factors were analyzed (median [range]): eastern cooperative oncology group performance status (ECOG PS), (1 [0–3]); Albumin (ALB), (39 g/L [24–47]); alkaline phosphatase (ALP), (110 U/L [35–1633]); and prostate‐specific antigen (PSA), (49 µg/L [0.83–7238]). The median OS for all patients was 14.5 months (95% CI: 11.2–18). These factors were associated with poor survival outcomes in UVA and MVA: ALB 150 U/L, ECOG PS 2–3, and PSA >80 µg/L. By assigning one point for each of these factors, a prognostic model was developed, wherein three distinct risk groups were identified: good, 0–1 (n = 103); intermediate, 2 (n = 30); and poor risk, 3–4 points (n = 17). The median OS was 19.4, 10.0, and 3.1 months, respectively (p

Published
2021
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41. Not Just for Libraries: The Value of the MLIS

Author

Freyja Catton

Subjects
MLIS, employment, LIS skills, Bibliography. Library science. Information resources
Abstract

The LIS job market is devastating, and the MLIS is no longer a guarantee of landing a library job. So, what’s the point? The MLIS is valuable because of the skills it teaches. Whether we work in a library or not, having an MLIS means that we know how to be leaders and advocates. We know how people look for information, and we can use that knowledge to help people find and evaluate information. We know how to organize information for most efficient retrieval. We know how to write grants and how to maintain relationships with stakeholders. Information is everywhere and always changing, and librarians are the ones who ensure we can keep up.

Published
2022
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42. Impact of patient and public (PPI) involvement in the Life After Prostate Cancer Diagnosis (LAPCD) study: a mixed-methods study

Author

Eila Watson, Adam W Glaser, Penny Wright, Anna Gavin, Jo Brett, Fiona Matley, Zoe Davey, Hugh Butcher, John Keenan, and Darryl Catton

Subjects
Medicine
Abstract

Objectives Standardised reporting of patient and public involvement (PPI) in research studies is needed to facilitate learning about how to achieve effective PPI. The aim of this evaluation was to explore the impact of PPI in a large UK study, the Life After Prostate Cancer Diagnosis (LAPCD) study, and to explore the facilitators and challenges experienced.Design Mixed-methods study using an online survey and semistructured interviews. Survey and topic guide were informed by systematic review evidence of the impact of PPI and by realist evaluation. Descriptive analysis of survey data and thematic analysis of interview data were conducted. Results are reported using the GRIPP2 (Guidance for Reporting Involvement of Patients and the Public, Version 2) reporting guidelines.Setting LAPCD study, a UK-wide patient-reported outcome study.Participants User Advisory Group (UAG) members (n=9) and researchers (n=29) from the LAPCD study.Results Impact was greatest on improving survey design and topic guides for interviews, enhancing clarity of patient-facing materials, informing best practices around data collection and ensuring steering group meetings were grounded in what is important to the patient. Further impacts included ensuring patient-focused dissemination of study findings at conference presentations and in lay summaries.Facilitating context factors included clear aims, time to contribute, confidence to contribute, and feeling valued and supported by researchers and other UAG members. Facilitating mechanisms included embedding the UAG within the study as a separate workstream, allocating time and resources to the UAG reflecting the value of input, and putting in place clear communication channels. Hindering factors included time commitment, geographical distance, and lack of standardised feedback mechanisms.Conclusion Including PPI as an integral component of the LAPCD study and providing the right context and mechanisms for involving the UAG helped maximise the programme’s effectiveness and impact.

Published
2022
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43. Surveillance testing using salivary RT-PCR for SARS-CoV-2 in managed quarantine facilities in Australia: A laboratory validation and implementation study

Author

Adam Jenney, Doris Chibo, Mitch Batty, Julian Druce, Robert Melvin, Andrew Stewardson, Amanda Dennison, Sally Symes, Paul Kinsella, Thomas Tran, Charlene Mackenzie, Douglas Johnson, Irani Thevarajan, Christian McGrath, Amelia Matlock, Jacqueline Prestedge, Megan Gooey, Janine Roney, Joanne Bobbitt, Sarah Yallop, Mike Catton, and Deborah A Williamson

Subjects
Surveillance testing, Saliva, SARS-CoV-2, COVID-19, RT-PCR, Public aspects of medicine, RA1-1270
Abstract

Summary: Background: Regular repeat surveillance testing is a strategy to identify asymptomatic individuals with SARS-CoV-2 infections in high-risk work settings to prevent onward community transmission. Saliva sampling is less invasive compared to nasal/oropharyngeal sampling, thus making it suitable for regular testing. In this multi-centre evaluation, we aimed to validate RT-PCR using salivary swab testing of SARS-CoV-2 for large-scale surveillance testing and assess implementation amongst staff working in the hotel quarantine system in Victoria, Australia. Methods: A multi-centre laboratory evaluation study was conducted to systematically validate the in vitro and clinical performance of salivary swab RT-PCR for implementation of SARS-CoV-2 surveillance testing. Analytical sensitivity for multiple RT-PCR platforms was assessed using a dilution series of known SARS-CoV-2 viral loads, and assay specificity was examined using a panel of viral pathogens other than SARS-CoV-2. In addition, we tested capacity for large-scale saliva testing using a four-sample pooling approach, where positive pools were subsequently decoupled and retested. Regular, frequent self-collected saliva swab RT-PCR testing was implemented for staff across fourteen quarantine hotels. Samples were tested at three diagnostic laboratories validated in this study, and results were provided back to staff in real-time. Findings: The agreement of self-collected saliva swabs for RT-PCR was 84.5% (95% CI 68.6 to 93.8) compared to RT-PCR using nasal/oropharyngeal swab samples collected by a healthcare practitioner, when saliva samples were collected within seven days of symptom onset. Between 7th December 2020 and 17th December 2021, almost 500,000 RT-PCR tests were performed on saliva swabs self-collected by 102 staff working in quarantine hotels in Melbourne. Of these, 20 positive saliva swabs were produced by 13 staff (0.004%). The majority of staff that tested positive occurred during periods of community transmission of the SARS-CoV-2 Delta variant. Interpretation: Salivary RT-PCR had an acceptable level of agreement compared to standard nasal/oropharyngeal swab RT-PCR within early symptom onset. The scalability, tolerability and ease of self-collection highlights utility for frequent or repeated testing in high-risk settings, such as quarantine or healthcare environments where regular monitoring of staff is critical for public health, and protection of vulnerable populations. Funding: This work was funded by the Victorian Department of Health.

Published
2022
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44. Comparative Longitudinal Serological Study of Anti-SARS-CoV-2 Antibody Profiles in People with COVID-19

Author

Marilou H. Barrios, Suellen Nicholson, Rowena A. Bull, Marianne Martinello, William Rawlinson, Michael Mina, Jeffrey J. Post, Bernard Hudson, Nicole Gilroy, Andrew R. Lloyd, Pamela Konecny, Francesca Mordant, Mike Catton, Kanta Subbarao, Leon Caly, Julian Druce, and Hans J. Netter

Subjects
SARS-CoV-2, serology, antibody profile, polyclonal durability, Biology (General), QH301-705.5
Abstract

Serological diagnostic assays are essential tools for determining an individual’s protection against viruses like SARS-CoV-2, tracking the spread of the virus in the community, and evaluating population immunity. To assess the diversity and quality of the anti-SARS-CoV-2 antibody response, we have compared the antibody profiles of people with mild, moderate, and severe COVID-19 using a dot blot assay. The test targeted the four major structural proteins of SARS-CoV-2, namely the nucleocapsid (N), spike (S) protein domains S1 and S2, and receptor-binding domain (RBD). Serum samples were collected from 63 participants at various time points for up to 300 days after disease onset. The dot blot assay revealed patient-specific differences in the anti-SARS-CoV-2 antibody profiles. Out of the 63 participants with confirmed SARS-CoV-2 infections and clinical COVID-19, 35/63 participants exhibited diverse and robust responses against the tested antigens, while 14/63 participants displayed either limited responses to a subset of antigens or no detectable antibody response to any of the antigens. Anti-N-specific antibody levels decreased within 300 days after disease onset, whereas anti-S-specific antibodies persisted. The dynamics of the antibody response did not change during the test period, indicating stable antibody profiles. Among the participants, 28/63 patients with restricted anti-S antibody profiles or undetectable anti-S antibody levels in the dot blot assay also exhibited weak neutralization activity, as measured by a surrogate virus neutralization test (sVNT) and a microneutralization test. These results indicate that in some cases, natural infections do not lead to the production of neutralizing antibodies. Furthermore, the study revealed significant serological variability among patients, regardless of the severity of their COVID-19 illness. These differences need to be carefully considered when evaluating the protective antibody status of individuals who have experienced primary SARS-CoV-2 infections.

Published
2023
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45. The long and winding road: perspectives of people and parents of children with mitochondrial conditions negotiating management after diagnosis

Author

Janet C. Long, Stephanie Best, Sarah Hatem, Tahlia Theodorou, Toni Catton, Sean Murray, Jeffrey Braithwaite, and John Christodoulou

Subjects
Qualitative research, Rare disease, Management, Consumer experience, Mitochondrial, Medicine
Abstract

Abstract Background The diagnostic odyssey for people with a rare disease is well known, but difficulties do not stop at diagnosis. Here we investigate the experience of people, or parents of children with a diagnosed mitochondrial respiratory chain disorder (MRCD) in the management of their disease. The work complements ongoing projects around implementation of consensus recommendations for management of people with MRCD. People with or caring for a child with a formally diagnosed MRCD were invited to take part in an hour-long focus group held via videoconference. Questions elicited experiences of receiving management advice or information specific to their MRCD in four areas drawn from the consensus recommendations: diet and supplements, exercise, access to social services, and mental health. Sessions were audio-recorded, transcribed and analysed using a combination of inductive and deductive coding. Results Focus groups were conducted with 20 participants from five Australian states in June–September 2020. Fourteen adults with a MRCD (three of whom also had a child with a MRCD), and six who cared for a child with a MRCD took part. The overarching finding was that of the need for ongoing negotiation to access the advice and service required to manage their condition. The nature of these negotiations varied across contexts but mostly related to joint decision-making, and more commonly, the need to advocate for their care with non-specialist services (e.g., dieticians, schools). The effort required for this self-advocacy was a prominent theme. While most participants reported receiving adequate advice around supplements, and to a lesser extent diet and exercise, the majority reported no formal advice around mental health or practical assistance accessing social services. Conclusion These focus groups have revealed several gaps in the system for people with a MRCD, interacting with care providers after diagnosis. Focus group participants had to negotiate with a range of different stakeholders in order to secure appropriate advice or services. Notable was the gap in appropriate generalist services (e.g., dieticians) with sufficient knowledge of MRCD to support people with their day-to-day challenges.

Published
2021
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47. Cascading impacts of a climate-driven ecosystem transition intensifies population vulnerabilities and fishery collapse

Author

Laura Rogers-Bennett and Cynthia A. Catton

Subjects
climate change, ecosystem shift, fisheries management, Haliotis spp., kelp deforestation, marine heatwave, Environmental sciences, GE1-350
Abstract

The recent large-scale intensification of marine heatwaves, and other climate-related stressors, has dramatically impacted biogenic habitats around the globe, including marine ecosystems such as coral reefs, seagrasses, and kelp forests. While the impacts to foundation species may be of particular concern, these ecological catastrophes underscore the need to examine how whole systems respond to a suite of stressors. The recent climate-driven collapse of the bull kelp forest and recreational red abalone fishery in northern California provides an example of unanticipated ripple and lagged effects in the system, intensifying vulnerabilities and accelerating population and fishery collapse. For this case study, we examined 15 years (2003–2018) of biological survey data on the bull kelp forest ecosystem—before, during, and after an extreme climate event. We document the interactions and complexity of impacts over time, as well as the resulting increased vulnerability of red abalone to additional anthropogenic, biological, and environmental stressors. We observed progressively stronger population-level responses of the red abalone to the marine heatwave and the regional loss of kelp, driving the movement of adults and juveniles in search of food. As food remained scarce, we documented the loss of productivity with diminished gonad and body condition, the absence of larval or newly-settled abalone, mass mortalities, and shoreward shifts in depth distributions. With 40% of the population dead or dying, juvenile and trophy-sized abalone abandoning cryptic habitats, the shift in the distribution to shallower depths increased the vulnerability of red abalone to the fishery. Other anthropogenic, biological, and climate-related stressors that disproportionately impact shallow habitats are now a growing concern for the survivors. For red abalone, previously unanticipated cascading risks include increased wave energy, warming air temperatures, freshwater flooding, landslides, as well as possible oil spills and harmful algal blooms. Climate-driven changes in vulnerability to fishing and environmental stressors present significant challenges for sustainable natural resource management in dynamic stressed systems, and underscore the need for continued system-focused monitoring. We present a conceptual framework supporting similar ecosystem investigations of recent and future climate impacts to inform adaptive ecosystem-based management strategies.

Published
2022
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50. Provision of Microbiology, Infection Services and Antimicrobial Stewardship in Intensive Care: A Survey across the Critical Care Networks in England and Wales

Author

Tim Catton, Helen Umpleby, Ahilanandan Dushianthan, and Kordo Saeed

Subjects
intensive care unit, antibiotic, infection, antibiotic stewardship, diagnostics, Therapeutics. Pharmacology, RM1-950
Abstract

Infection rounds in Intensive Care Units (ICU) can impact antimicrobial stewardship (AMS). The aim of this survey was to assess the availability of microbiology, infection, AMS services, and antimicrobial prescribing practices in the UK ICUs. An online questionnaire was sent to clinical leads for ICUs in each region listed in the Critical Care Network for the UK. Out of 217 ICUs, 87 deduplicated responses from England and Wales were analyzed. Three-quarters of those who responded had a dedicated microbiologist, and 50% had a dedicated infection control prevention nurse. Infection rounds varied in their frequency, with 10% providing phone advice only. Antibiotic guidance was available in 99% of the units; only 8% of those were ICU-specific. There were variations in the availability of biomarkers & the duration of antibiotics prescribed for pneumonia (community, hospital, or ventilator), urinary, intra-abdominal, and line infections/sepsis. Antibiotic consumption data were not routinely discussed in a multi-disciplinary meeting. The electronic prescription was available in ~60% and local antibiotic surveillance data in only 47% of ICUs. The survey highlights variations in practice and AMS services and may offer the opportunity to further collaborations and share learnings to support the safe use of antimicrobials in the ICU.

Published
2023
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