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3. Pragmatic solutions to reduce the global burden of stroke: a World Stroke Organization–Lancet Neurology Commission

Author

Feigin, Valery L, Abd-Allah, Foad, Akinyemi, Rufus O, Bhattacharjee, Natalia V, Brainin, Michael, Cao, Jackie, Caso, Valeria, Dalton, Bronte, Davis, Alan, Dempsey, Robert, Duprey, Joseph, Feng, Wuwei, Ford, Gary A, Gall, Seana, Gandhi, Dorcas, Good, David C, Hachinski, Vladimir, Hacke, Werner, Hankey, Graeme J, Ishida, Marie, Johnson, Walter, Kim, Julie, Lavados, Pablo, Lindsay, Patrice, Mahal, Ajay, Martins, Sheila, Murray, Christopher, Nguyen, Thuy Phuong, Norrving, Bo, Olaiya, Muideen T, Olalusi, Oladotun V, Pandian, Jeyaraj, Phan, Hoang, Platz, Thomas, Ranta, Anna, Rehman, Sabah, Roth, Greg, Sebastian, Ivy Anne, Smith, Amanda E, Suwanwela, Nijasri C, Sylaja, P N, Thapa, Rajshree, Thrift, Amanda G, Uvere, Ezinne, Vollset, Stein Emil, Yavagal, Dileep, Yaria, Joseph, Owolabi, Mayowa O, Abera, Semaw Ferede, Akinyemi, Rufus, Dempsey, Robert J, Ibrahim, Norlinah Mohamed, Liu, Liping, Ovbiagele, Bruce, Piradov, Michael, Suwanwela, Nijasri, Abanto, Carlos, Addissie, Adamu, Adeleye, Amos O, Adilbekov, Yerzhan, Adilbekova, Bibigul, Adoukonou, Thierry A, Aguiar de Sousa, Diana, Akhmetzhanova, Zauresh, Akpalu, Albert, El Alaoui-Faris, Mustapha, Ameriso, Sebastian F, Andonova, Silva, Arsovska, Anita, Awoniyi, Folorunso E, Bakhiet, Moiz, Barboza, Miguel A, Basri, Hamidon, Bath, Philip M, Bereczki, Daniel, Beretta, Simone, Berkowitz, Aaron L, Bernhardt, Julie, Berzina, Guna, Bhavsar, Bhavan, Bisharyan, Mher S, Bohara, Manoj, Bovet, Pascal, Budincevic, Hrvoje, Cadilhac, Dominique A, Čerimagić, Denis, Charway-Felli, Augustina, Chen, Christopher, Chin, Jerome H, Christensen, Hanne, Chwojnicki, Kamil, Conforto, Adriana B, Correia, Manuel, Mora Cuervo, Daissy L, Członkowska, Anna, D'Amelio, Marco, Danielyan, Kristine E, Davis, Stephen, Demarin, Vida, Demchuk, Andrew M, Dichgans, Martin, Dokova, Klara, Donnan, Geoffrey, Duran, Juan Carlos, Ekeng, Gloria, Elkind, Mitchell S, Endres, Matthias, Fischer, Urs, Flomin, Yuriy, Gankpe, Fortuné, Gavidia, Martin, Gaye Saavedra, Andrés, Gebreyohanns, Mehari, George, Mary, Gierlotka, Marek, Giroud, Maurice, Gnedovskaya, Elena V, Gonçalves, Ivete Pillo, Gongora-Rivera, Fernando, Gunaratne, Padma S, Hamadeh, Randah R, Hamzat, Tal-hatu K, Heldner, Mirjam R, Ibrahim, Etedal, Ihle-Hansen, Hanne, Jee, Sungju, Jiann-Shing, Jeng, Johnston, S Clay, Jovanovic, Dejana, Jurjāns, Kristaps, Kalani, Rizwan, Kalkonde, Yogeshwar, Kamenova, Saltanat, Karaszewski, Bartosz, Kelly, Peter, Kiechl, Stefan, Kondybayeva, Aida, Kõrv, Janika, Kozera, Grzegorz, Kravchenko, Michael, Krespi, Yakup, Krishnamurthi, Rita, Kruja, Jera, Kutluk, Kursad, Langhorne, Peter, Law, Zhe K, Lebedynets, Dmytro, Lee, Tsong-Hai, Leung, Thomas W, Liebeskind, David S, López-Jaramillo, Patricio, Lotufo, Paulo A, Machline-Carrion, M Julia, Maia, Luis F, Malojcic, Branko, Markus, Hugh S, Marquez-Romero, Juan M, Medina, Marco T, Medukhanova, Sabina, Mehndiratta, Man Mohan, Miglāne, Evija, Mihejeva, Illa, Mikulik, Robert, Mirrakhimov, Erkin, Mohl, Stephanie, Munakomi, Sunil, Murphy, Sean, Musa, Kamarul I, Nasreldein, Ahmed, Nogueira, Raul G, Nolte, Christian H, Noubiap, Jean Jacques, Novarro-Escudero, Nelson, Ocampo, Cassandra, O'Donnell, Martin, Ogun, Yomi, Ogunniyi, Adesola, Oraby, Mohammed I, Ōrken, Dilek N, Ōzdemir, Atilla O, Ozturk, Serefnur, Paccot, Mélanie, Pereira, Telmo, Peeters, André, Potpara, Tatjana, Proios, Hariklia, Rathore, Farooq A, Sacco, Ralph L, Sahathevan, Ramesh, Sandset, Else S, Renato Santos, Irving, Saposnik, Gustavo, Sarfo, Fred S, Sargento-Freitas, João, Sharma, Mukul, Shaw, Louise, Sheth, Kevin N, Shin, Yong-Il, Shobhana, A, Silva, S Nishan, Tedim Cruz, Vitor, Thakur, Kiran, Thapa, Lekh Jung, Toni, Danilo, Topcuoglu, Mehmetakif A, Torales, Julio, Towfighi, Amytis, Truelsen, Thomas, Tsiskaridze, Alexander, Tulloch-Reid, Marshall, Useche, Juan N, Vanacker, Peter, Vassilopoulou, Sophia, Vukorepa, Gorana, Vuletic, Vladimira, Wahab, Kolawole W, Wang, Wenzhi, Wijeratne, Tissa, Wojtyniak, Bogdan, Wolfe, Charles, Yacouba, Mapoure N, Yang, Jie, Yifru, Yared M, Yock-Corrales, Adriana, Yonemoto, Naohiro, Yperzeele, Laetitia, and Zagożdżon, Pawel

Published
2023
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8. The Effect of Tranexamic Acid on Neurosurgical Intervention in Spontaneous Intracerebral Hematoma: Data From 121 Surgically Treated Participants From the Tranexamic Acid in IntraCerebral Hemorrhage-2 Randomized Controlled Trial.

Author

Hollingworth, Milo, Woodhouse, Lisa J., Zhe K. Law, Ali, Azlinawati, Krishnan, Kailash, Dineen, Robert A., Christensen, Hanne, England, Timothy J., Roffe, Christine, Werring, David, Peters, Nils, Ciccone, Alfonso, Robinson, Thompson, Członkowska, Anna, Bereczki, Dániel, Egea-Guerrero, Juan José, Ozturk, Serefnur, Bath, Philip M., and Sprigg, Nikola

Published
2024
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9. Effect of continuing versus stopping pre-stroke antihypertensive agents within 12 h on outcome after stroke: A subgroup analysis of the efficacy of nitric oxide in stroke (ENOS) trial

Author

Woodhouse, Lisa J., Appleton, Jason P., Scutt, Polly, Everton, Lisa, Wilkinson, Gwenllian, Caso, Valeria, Czlonkowska, Anna, Gommans, John, Krishnan, Kailash, Laska, Ann C., Ntaios, George, Ozturk, Serefnur, Phillips, Stephen, Pocock, Stuart, Prasad, Kameshwar, Szatmari, Szabolcs, Wardlaw, Joanna M., Sprigg, Nikola, and Bath, Philip M.

Published
2022
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10. Primary stroke prevention worldwide: translating evidence into action

Author

Abanto, Carlos, Abera, Semaw Ferede, Addissie, Adamu, Adebayo, Oluwadamilola, Adeleye, Amos Olufemi, Adilbekov, Yerzhan, Adilbekova, Bibigul, Adoukonou, Thierry Armel, Aguiar de Sousa, Diana, Ajagbe, Temitope, Akhmetzhanova, Zauresh, Akpalu, Albert, Álvarez Ahlgren, Jhon, Ameriso, Sebastián, Andonova, Silva, Awoniyi, Foloruso Emmanuel, Bakhiet, Moiz, Barboza, Miguel, Basri, Hamidon, Bath, Philip, Bello, Olamide, Bereczki, Dániel, Beretta, Simone, Berkowitz, Aaron, Bernabé-Ortiz, Antonio, Bernhardt, Julie, Berzina, Guna, Bisharyan, Mher, Bovet, Pascal, Budincevic, Hrvoje, Cadilhac, Dominique, Caso, Valeria, Chen, Christopher, Chin, Jerome, Chwojnicki, Kamil, Conforto, Adriana, Cruz, Vitor Tedim, D'Amelio, Marco, Danielyan, Kristine, Davis, Stephen, Demarin, Vida, Dempsey, Robert, Dichgans, Martin, Dokova, Klara, Donnan, Geoffrey, Elkind, Mitchell S., Endres, Matthias, Fischer, Urs, Gankpé, Fortuné, Gaye Saavedra, Andrés, Gil, Artyom, Giroud, Maurice, Gnedovskaya, Elena, Hachinski, Vladimir, Hafdi, Melanie, Hamadeh, Randah, Hamzat, T. Kolapo, Hankey, Graeme, Heldner, Mirjam, Ibrahim, Etedal Ahmed, Ibrahim, Norlinah Mohamed, Inoue, Manabu, Jee, Sungju, Jeng, Jiann-Shing, Kalkonde, Yogesh, Kamenova, Saltanat, Karaszewski, Bartosz, Kelly, Peter, Khan, Taskeen, Kiechl, Stefan, Kondybayeva, Aida, Kõrv, Janika, Kravchenko, Michael, Krishnamurthi, Rita V., Kruja, Jera, Lakkhanaloet, Mongkol, Langhorne, Peter, Lavados, Pablo M., Law, Zhe Kang, Lawal, Abisola, Lazo-Porras, Maria, Lebedynets, Dmytro, Lee, Tsong-Hai, Leung, Thomas, Liebeskind, David S., Lindsay, Patrice, López-Jaramillo, Patricio, Lotufo, Paulo Andrade, Machline-Carrion, Julia, Makanjuola, Akintomiwa, Markus, Hugh Stephen, Marquez-Romero, Juan Manuel, Medina, Marco, Medukhanova, Sabina, Mehndiratta, Man Mohan, Merkin, Alexandr, Mirrakhimov, Erkin, Mohl, Stephanie, Moscoso-Porras, Miguel, Müller-Stierlin, Annabel, Murphy, Sean, Musa, Kamarul Imran, Nasreldein, Ahmed, Nogueira, Raul Gomes, Nolte, Christian, Noubiap, Jean Jacques, Novarro-Escudero, Nelson, Ogun, Yomi, Oguntoye, Richard Ayobami, Oraby, Mohammed Ibrahim, Osundina, Morenike, Ovbiagele, Bruce, Orken, Dilek Necioglu, Ozdemir, Atilla Özcan, Ozturk, Serefnur, Paccot, Melanie, Phromjai, Jurairat, Piradov, Piradov, Platz, Thomas, Potpara, Tatjana, Ranta, Annemarei, Rathore, Farooq, Richard, Edo, Sacco, Ralph L., Sahathevan, Ramesh, Santos Carquín, Irving, Saposnik, Gustavo, Sarfo, Fred Stephen, Sharma, Mike, Sheth, Kevin, Shobhana, A., Suwanwela, Nijasri, Svyato, Irina, Sylaja, P.N., Tao, Xuanchen, Thakur, Kiran T., Toni, Danilo, Topcuoglu, Mehmet Akif, Torales, Julio, Towfighi, Amytis, Truelsen, Thomas Clement, Tsiskaridze, Alexander, Tulloch-Reid, Marshall, Useche, Nicolás, Vanacker, Peter, Vassilopoulou, Sophia, Vukorepa, Gorana, Vuletic, Vladimira, Wahab, Kolawole W., Wang, Wenzhi, Wijeratne, Tissa, Wolfe, Charles, Yifru, Yared Mamushet, Yock-Corrales, Adriana, Yonemoto, Naohiro, Yperzeele, Laetitia, Zhang, Puhong, Owolabi, Mayowa O, Thrift, Amanda G, Mahal, Ajay, Ishida, Marie, Martins, Sheila, Johnson, Walter D, Pandian, Jeyaraj, Abd-Allah, Foad, Yaria, Joseph, Phan, Hoang T, Roth, Greg, Gall, Seana L, Beare, Richard, Phan, Thanh G, Mikulik, Robert, Akinyemi, Rufus O, Norrving, Bo, Brainin, Michael, and Feigin, Valery L

Published
2022
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11. General neurology: Current challenges and future implications

Author

Bassetti, Claudio Lino Alberto, primary, Accorroni, Alice, additional, Arnesen, Astri, additional, Basri, Hamidon Bin, additional, Berger, Thomas, additional, Berlit, Peter, additional, Boon, Paul, additional, Charway‐Felli, Augustina, additional, Kruja, Jera, additional, Lewis, Steven, additional, Markowski, Michael, additional, Medina, Marco Tulio, additional, McCombe, Pamela, additional, Moro, Elena, additional, Ozturk, Serefnur, additional, Smith, Paul, additional, and Vuletic, Vladimira, additional

Published
2024
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13. Evaluation of Stroke Patients Diagnosed with Rheumatologic Diseases.

Author

Ozguncu, Cihat, Ozturk, Serefnur, and Ozdemir, ²Gokhan

Abstract

Objectives: Some comorbid diseases are recognized as specific risk factors for stroke. Rheumatological diseases constitute an important group of these diseases. In our study, we evaluated patients who were followed up for stroke in our clinic. We included patients with additional rheumatological diagnoses in a separate group and attempted to determine their differences from patients without a diagnosis. In this way, we aimed to investigate the effect of rheumatological comorbidity on prognosis in stroke patients. Material and methods: In the study, we included patients who were admitted to our hospital between 2016-2020, and diagnosed with ischemic stroke, hemorrhagic stroke, transient ischemic attack, hemorrhagic infarction, and were hospitalized. Age, gender, stroke subtype, need for intensive care and exitus status of these patients were recorded. We compared patients with a rheumatological diagnosis to patients with other stroke diagnoses using appropriate statistical methods. Results: 2053 patients with an average age of 66.22±14.33 participated in the study. A total of 37 patients were diagnosed with at least 1 rheumatological disease. We calculated the average age of these patients as 51.62±15.88. Compared to patients without a diagnosis of rheumatological disease, the age was significantly lower(p<0.001). However, we did not find a significant relationship between the distribution of stroke subtypes(p=0.538), and there was no significant difference in terms of gender(p=0.149). No statistical significance was observed in intensive care unit admissions and exitus rates. (p=0.384,0.868) Conclusion: Some rheumatologic diseases are known to be linked to stroke risk. In our study, we did not observe a significant difference between the groups in terms of prognosis. Having a history of stroke is an independent risk factor for developing stroke in the future. We believe that since patients with a rheumatological diagnosis have a stroke at a younger age, their risk of a subsequent stroke increases, and their follow-up should be more frequent. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Epileptic seizures in cerebral venous sinus thrombosis: Subgroup analysis of VENOST study

Author

Uluduz, Derya, Midi, Ipek, Duman, Taskin, Yayla, Vildan, Karahan, Ali Yavuz, Afsar, Nazire, Goksu, Eylem Ozaydin, Mengulluoglu, Necdet, Aytac, Emrah, Sungur, Mehmet Ali, Yesilot, Nilufer, Ince, Birsen, Yalin, Osman Ozgur, Oruc, Serdar, Senol, Mehmet Guney, Yilmaz, Arda, Gokce, Mustafa, Demirci, Seden, Kusbeci, Ozge Yilmaz, Uzuner, Gulnur, Caglayan, Hale Zeynep Batur, Acikgoz, Mustafa, Kurucu, Hatice, Ozdag, Fatih, Baybas, Sevim, Ekmekci, Hakan, Cabala, Murat, Yaman, Mehmet, Yürekli, Vedat Ali, Tekeli, Hakan, Genc, Hamit, Utku, Uygar, Sahin, Sevki, Tokuc, Firdevs Ezgi Ucan, Uzuner, Nevzat, Bektas, Hesna, Kablan, Yuksel, Goksel, Basak Karakurum, Milanlioglu, Aysel, Orken, Dilek Necioglu, Aluclu, Ufuk, Colakoglu, Sena, Tufekci, Ahmet, Bakar, Mustafa, Nazliel, Bijen, Tascilar, Nida, Goksan, Baki, Kozak, Hasan Huseyin, Demir, Serkan, Mısırli, Cemile Handan, Kucukoglu, Hayriye, Cinar, Nilgun, Domac, Fusun Mayda, Ozturk, Serefnur, and Gunes, Taskin

Published
2020
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18. Evaluation of the effect of air pollution on cognitive functions, cognitive decline, and dementia

Author

Eren, Fettah and Ozturk, Serefnur

Subjects
Air pollution -- Health aspects, Cognition disorders -- Risk factors -- Development and progression -- Environmental aspects, Particles -- Health aspects, Health
Abstract

Byline: Fettah. Eren, Serefnur. Ozturk The incidence of dementia increases with aging. It is known that the disease brings with it many problems for patients and caregivers. Studies on the [...]

Published
2022

19. Characterization of Patients with Embolic Strokes of Undetermined Source in the NAVIGATE ESUS Randomized Trial

Author

Kasner, Scott E., Lavados, Pablo, Sharma, Mukul, Wang, Yongjun, Wang, Yilong, Dávalos, Antoni, Shamalov, Nikolay, Cunha, Luis, Lindgren, Arne, Mikulik, Robert, Arauz, Antonio, Lang, Wilfried, Czlonkowska, Anna, Eckstein, Jens, Gagliardi, Rubens, Amarenco, Pierre, Ameriso, Sebastián F., Tatlisumak, Turgut, Veltkamp, Roland, Hankey, Graeme J., Toni, Danilo S., Bereczki, Daniel, Uchiyama, Shinichiro, Ntaios, George, Yoon, Byung-Woo, Brouns, Raf, DeVries Basson, M.M., Endres, Matthias, Muir, Keith, Bornstein, Natan, Ozturk, Serefnur, O'Donnell, Martin, Mundl, Hardi, Pater, Calin, Weitz, Jeffrey, Peacock, W. Frank, Swaminathan, Balakumar, Kirsch, Bodo, Berkowitz, Scott D., Peters, Gary, Pare, Guillaume, Themeles, Ellison, Shoamanesh, Ashkan, Connolly, Stuart J., and Hart, Robert G.

Published
2018
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20. Elevated Urinary Methylmalonic Acid/creatinine ratio and Serum Sterol levels in Patients with Acute Ischemic Stroke

Author

Sivrikaya Abdullah, Ozturk Serefnur, Ekmekci Hakan, Sağlam Aslıhan, Abusoglu Sedat, and Unlu Ali

Subjects
sterol, stroke, oxidized ldl, methylmalonic acid, creatinine, Medicine
Abstract

Introduction: Sitosterolemia, defined as phytosterolemia, is a rare autosomal recessive disease characterized by elevated blood sterol levels. Our aim was to investigate serum plant sterols, methylmalonic acid, vitamin B12, oxidized-LDL and homocysteine levels in ischemic and hemorrhagic stroke patients and healthy subjects. Material and Methods: 50 healthy subjects (without a family history of coronary artery disease) and 89 patients hospitalized in the Selcuk University neurology clinic or intensive care unit with a diagnosis of stroke were included in this study. Serum plant sterols, homocysteine and methylmalonic acid, oxidized-LDL, total cholesterol, triglycerides, HDL-Cholesterol and vitamin B12 levels were analyzed by gas chromatography-mass spectrometry, liquid-chromatography tandem mass spectrometry, commercially available ELISA kit, spectrophotometry and chemiluminescence methods, respectively. Results: Urinary methylmalonic acid/creatinine ratio (p< 0.05), serum β-sitosterol levels and β-sitosterol/ cholesterol ratio were significantly higher (p

Published
2018
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22. Effects of blood pressure and tranexamic acid in spontaneous intracerebral haemorrhage: a secondary analysis of a large randomised controlled trial

Author

Appleton, Jason Philip, primary, Law, Zhe Kang, additional, Woodhouse, Lisa Jane, additional, Al-Shahi Salman, Rustam, additional, Beridze, Maia, additional, Christensen, Hanne, additional, Dineen, Robert A, additional, Guerrero, Juan José Egea, additional, England, Timothy J, additional, Karlinski, Michal, additional, Krishnan, Kailash, additional, Laska, Ann Charlotte, additional, Lyrer, Philippe, additional, Ozturk, Serefnur, additional, Roffe, Christine, additional, Roberts, Ian, additional, Robinson, Thompson G, additional, Scutt, Polly, additional, Werring, David J, additional, Bath, Philip M, additional, and Sprigg, Nikola, additional

Published
2023
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23. A Multicenter Study of 1144 Patients with Cerebral Venous Thrombosis: The VENOST Study

Author

Colakoglu, Sena, Tüfekci, Ahmet, Bakar, Mustafa, Nazliel, Bijen, Tascilar, Nida, Goksan, Baki, Kozak, Hasan Huseyin, Demir, Serkan, Misirli, Cemile Handan, Kucukoglu, Hayriye, Cinar, Nilgun, Domac, Fusun Mayda, Ozturk, Serefnur, Yayla, Vildan, Karahan, Ali Yavuz, Afsar, Nazire, Ozaydin Goksu, Eylem, Mengulluoglu, Necdet, Aytac, Emrah, Yesilot, Nilufer, Ince, Birsen, Yalin, Özgur Osman, Oruc, Serdar, Demirci, Seden, Senol, Mehmet Guney, Yilmaz, Arda, Gokce, Mustafa, Kuspeci, Özge Yilmaz, Uzuner, Gulnur, Caglayan, Hale Zeynep Batur, Acıkgoz, Mustafa, Zeydan, Burcu, Ozdag, Fatih, Baybas, Sevim, Ekmekci, Hakan, Cabalar, Murat, Yaman, Mehmet, Yurekli, Vedat Ali, Tekeli, Hakan, Genc, Hamit, Utku, Uygar, Ucan Tokuc, Firdevs Ezgi, Uzuner, Nevzat, Duman, Taskin, Uluduz, Derya, Midi, Ipek, Bektas, Hesna, Kablan, Yuksel, Goksel, Basak K., Milanlioglu, Aysel, Necioglu Orken, Dilek, and Aluclu, Ufuk

Published
2017
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24. The effects of blood pressure and tranexamic acid in spontaneous intracerebral haemorrhage: a secondary analysis of a large randomised controlled trial

Author

Appleton, Jason P, Law, Zhe Kang, Woodhouse, Lisa J, Al-Shahi Salman, Rustam, Beridze, Maia, Christensen, Hanne, Dineen, Robert A., Egea-Guerrero, Juan Jose, England, Timothy J., Karlinski, Michal, Krishnan, Kailash, Laska, Ann Charlotte, Lyrer, Philippe A., Ozturk, Serefnur, Roffe, Christine, Roberts, Ian S, Robinson, Thompson G, Scutt, Polly, Werring , David J, Bath, Philip M, and Sprigg, Nikola

Published
2023

26. Route of Feeding as a Proxy for Dysphagia After Stroke and the Effect of Transdermal Glyceryl Trinitrate: Data from the Efficacy of Nitric Oxide in Stroke Randomised Controlled Trial

Author

Woodhouse, Lisa J, Scutt, Polly, Hamdy, Shaheen, Smithard, David G, Cohen, David L, Roffe, Christine, Bereczki, Daniel, Berge, Eivind, Bladin, Christopher F, Caso, Valeria, Christensen, Hanne K, Collins, Rónán, Czlonkowska, Anna, de Silva, Asita, Etribi, Anwar, Laska, Ann-Charlotte, Ntaios, George, Ozturk, Serefnur, Phillips, Stephen J, Prasad, Kameshwar, Szatmari, Szabolcs, Sprigg, Nikola, and Bath, Philip M

Published
2018
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27. Determinants of in-hospital muscle loss in acute ischemic stroke – Results of the Muscle Assessment in Stroke Study (MASS)

Author

Gungor, Levent, primary, Arsava, Ethem Murat, additional, Guler, Ayse, additional, Togay Isikay, Canan, additional, Aykac, Ozlem, additional, Batur Caglayan, Hale Zeynep, additional, Kozak, Hasan Huseyin, additional, Aydingoz, Ustun, additional, Topcuoglu, Mehmet Akif, additional, Akpinar, Erhan, additional, Argin, Mehmet, additional, Bugrul, Ahmet, additional, Eryildiz, Ezgi Sezer, additional, Giray, Semih, additional, Inanc, Yusuf, additional, Kesen, Sevcihan, additional, Nazliel, Bijen, additional, Ozdemir, Atilla Ozcan, additional, Ozturk, Serefnur, additional, Peynir, Sehripabn, additional, Polat, Ahmet Veysel, additional, Poyraz, Necdet, additional, Sirin, Hadiye, additional, Sorgun, Mine Hayriye, additional, and Uzun, Caglar, additional

Published
2023
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28. Effects of blood pressure and tranexamic acid in spontaneous intracerebral haemorrhage: a secondary analysis of a large randomised controlled trial

Author

National Institutes of Health (US), Swiss Heart Foundation, Appleton, Jason Philip, Law, Zhe Kang, Woodhouse, Lisa Jane, Al-Shahi Salman, Rustam, Beridze, Maia, Christensen, Hanne, Dineen, Robert A., Egea-Guerrero, Juan José, England, Timothy J., Karlinski, Michal, Krishnan, Kailash, Laska, Ann Charlotte, Lyrer, Philippe, Ozturk, Serefnur, Roffe, Christine, Roberts, Ian, Robinson, Thompson G., Scutt, Polly, Werring, David J., Bath, Philip M., Sprigg, Nikola, National Institutes of Health (US), Swiss Heart Foundation, Appleton, Jason Philip, Law, Zhe Kang, Woodhouse, Lisa Jane, Al-Shahi Salman, Rustam, Beridze, Maia, Christensen, Hanne, Dineen, Robert A., Egea-Guerrero, Juan José, England, Timothy J., Karlinski, Michal, Krishnan, Kailash, Laska, Ann Charlotte, Lyrer, Philippe, Ozturk, Serefnur, Roffe, Christine, Roberts, Ian, Robinson, Thompson G., Scutt, Polly, Werring, David J., Bath, Philip M., and Sprigg, Nikola

Abstract

[Background] Tranexamic acid reduced haematoma expansion and early death, but did not improve functional outcome in the tranexamic acid for hyperacute spontaneous intracerebral haemorrhage-2 (TICH-2) trial. In a predefined subgroup, there was a statistically significant interaction between prerandomisation baseline systolic blood pressure (SBP) and the effect of tranexamic acid on functional outcome (p=0.019)., [Methods] TICH-2 was an international prospective double-blind placebo-controlled randomised trial evaluating intravenous tranexamic acid in patients with acute spontaneous intracerebral haemorrhage (ICH). Prerandomisation baseline SBP was split into predefined ≤170 and >170 mm Hg groups. The primary outcome at day 90 was the modified Rankin Scale (mRS), a measure of dependency, analysed using ordinal logistic regression. Haematoma expansion was defined as an increase in haematoma volume of >33% or >6 mL from baseline to 24 hours. Data are OR or common OR (cOR) with 95% CIs, with significance at p<0.05., [Results] Of 2325 participants in TICH-2, 1152 had baseline SBP≤170 mm Hg and were older, had larger lobar haematomas and were randomised later than 1173 with baseline SBP>170 mm Hg. Tranexamic acid was associated with a favourable shift in mRS at day 90 in those with baseline SBP≤170 mm Hg (cOR 0.73, 95% CI 0.59 to 0.91, p=0.005), but not in those with baseline SBP>170 mm Hg (cOR 1.05, 95% CI 0.85 to 1.30, p=0.63). In those with baseline SBP≤170 mm Hg, tranexamic acid reduced haematoma expansion (OR 0.62, 95% CI 0.47 to 0.82, p=0.001), but not in those with baseline SBP>170 mm Hg (OR 1.02, 95% CI 0.77 to 1.35, p=0.90)., [Conclusions] Tranexamic acid was associated with improved clinical and radiological outcomes in ICH patients with baseline SBP≤170 mm Hg. Further research is needed to establish whether certain subgroups may benefit from tranexamic acid in acute ICH., [Trial registration number] ISRCTN93732214.

Published
2023

29. Continuing versus Stopping Prestroke Antihypertensive Therapy in Acute Intracerebral Hemorrhage: A Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke Trial

Author

Krishnan, Kailash, Scutt, Polly, Woodhouse, Lisa, Adami, Alessandro, Becker, Jennifer L., Cala, Lesley A., Casado, Ana M., Chen, Christopher, Dineen, Robert A., Gommans, John, Koumellis, Panos, Christensen, Hanna, Collins, Ronan, Czlonkowska, Anna, Lees, Kennedy R., Ntaios, George, Ozturk, Serefnur, Phillips, Stephen J., Sprigg, Nikola, Szatmari, Szabolcs, Wardlaw, Joanna M., and Bath, Philip M.

Published
2016
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32. Comparative features and outcomes of major neurological complications of COVID-19

Author

Beghi, Ettore, Moro, Elena, Davidescu, Eugenia Irene, Popescu, Bogdan Ovidiu, Grosu, Oxana, Valzania, Franco, Cotelli, Maria Sofia, Kiteva-Trenchevska, Gordana, Zakharova, Maria, Kovács, Tibor, Armon, Carmel, Brola, Waldemar, Yasuda, Clarissa Lin, Maia, Luís F, Lovrencic-Huzjan, Arijana, de Seabra, Mafalda Maria Laracho, Avalos-Pavon, Rafael, Aamodt, Anne Hege, Meoni, Sara, Gryb, Victoria, Ozturk, Serefnur, Karadas, Omer, Krehan, Ingomar, Leone, Maurizio A, Lolich, Maria, Bianchi, Elisa, Rass, Verena, Helbok, Raimund, and Bassetti, Claudio L A

Subjects
610 Medicine & health
Abstract

BACKGROUND AND PURPOSE The aim of this study was to assess the neurological complications of SARS-CoV-2 infection and compare phenotypes and outcomes in infected patients with and without selected neurological manifestations. METHODS The data source was a registry established by the European Academy of Neurology during the first wave of the COVID-19 pandemic. Neurologists collected data on patients with COVID-19 seen as in- and outpatients and in emergency rooms in 23 European and seven non-European countries. Prospective and retrospective data included patient demographics, lifestyle habits, comorbidities, main COVID-19 complications, hospital and intensive care unit admissions, diagnostic tests, and outcome. Acute/subacute selected neurological manifestations in patients with COVID-19 were analysed, comparing individuals with and without each condition for several risk factors. RESULTS By July 31, 2021, 1523 patients (758 men, 756 women, and nine intersex/unknown, aged 16-101 years) were registered. Neurological manifestations were diagnosed in 1213 infected patients (79.6%). At study entry, 978 patients (64.2%) had one or more chronic general or neurological comorbidities. Predominant acute/subacute neurological manifestations were cognitive dysfunction (N = 449, 29.5%), stroke (N = 392, 25.7%), sleep-wake disturbances (N = 250, 16.4%), dysautonomia (N = 224, 14.7%), peripheral neuropathy (N = 145, 9.5%), movement disorders (N = 142, 9.3%), ataxia (N = 134, 8.8%), and seizures (N = 126, 8.3%). These manifestations tended to differ with regard to age, general and neurological comorbidities, infection severity and non-neurological manifestations, extent of association with other acute/subacute neurological manifestations, and outcome. CONCLUSIONS Patients with COVID-19 and neurological manifestations present with distinct phenotypes. Differences in age, general and neurological comorbidities, and infection severity characterize the various neurological manifestations of COVID-19.

Published
2023
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33. Infections Up to 76 Days After Stroke Increase Disability and Death

Author

Learoyd, Annastazia E., Woodhouse, Lisa, Shaw, Laurence, Sprigg, Nikola, Bereczki, Daniel, Berge, Eivind, Caso, Valeria, Christensen, Hanne, Collins, Ronan, Czlonkowska, Anna, El Etribi, Anwar, Farr, Tracy D., Gommans, John, Laska, Ann-Charlotte, Ntaios, George, Ozturk, Serefnur, Pocock, Stuart J., Prasad, Kameshwar, Wardlaw, Joanna M., Fone, Kevin C., Bath, Philip M., Trueman, Rebecca C., and on behalf of the ENOS Trial investigators

Published
2017
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34. Assessment of safety and feasibility of non-invasive vagus nerve stimulation for treatment of acute stroke

Author

Arsava, Ethem Murat, primary, Topcuoglu, Mehmet Akif, additional, Ay, Ilknur, additional, Ozdemir, Atilla Ozcan, additional, Gungor, Ibrahim Levent, additional, Togay Isikay, Canan, additional, Nazliel, Bijen, additional, Kozak, Hasan Huseyin, additional, Ozturk, Serefnur, additional, Yilmaz, İbrahim Arda, additional, Dora, Babur, additional, Ay, Hakan, additional, Unal, Ali, additional, Ozel, Tugba, additional, Sorgun, Mine Hayriye, additional, Bahadır, Eda Aslanbaba, additional, Peker, Elif, additional, Aykac, Ozlem, additional, Mehdiyev, Zaur, additional, Caglayan, Hale Zeynep Batur, additional, Gurses, Asli Akyol, additional, Pektezel, Mehmet Yasir, additional, Yilmaz, Ezgi, additional, Oge, Dogan Dinc, additional, Parlak, Safak, additional, Bugrul, Ahmet, additional, Ozguner, Hilal, additional, Seker, Aysu Cetiner, additional, Ozdemir, Gokhan, additional, Ongun, Gozde, additional, Yilmaz, Sueda Ecem, additional, Ozguncu, Cihat, additional, Turan Isik, Saziye Melike, additional, Ildiz, Omer Faruk, additional, Mammadli, Azer, additional, Yildogan, Aydin Talip, additional, and McClure, Candace, additional

Published
2022
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36. The European Academy of Neurology COVID‐19 registry (ENERGY): an international instrument for surveillance of neurological complications in patients with COVID‐19

Author

Beghi, Ettore, Helbok, Raimund, Crean, Michael, Chou, Sherry Hsiang‐Yi, McNett, Molly, Moro, Elena, Bassetti, Claudio, Jenkins, Tom, Oertzen, Tim, Bodini, Benedetta, Marcerollo, Antonella, Rakusa, Martin, Soffietti, Riccardo, Oreja‐Guevara, Celia, Bereczki, Daniel, Ozturk, Serefnur, Pisani, Antonio, Sellner, Johann, Taba, Pille, Diliberto, Giovanni, Leys, Didier, Sauerbier, Anna, Cavallieri, Francesco, Priori, Alberto, and Zedde, Marialuisa

Subjects
Adult, medicine.medical_specialty, Neurology, complications, Coronavirus disease 2019 (COVID-19), Clinical Neurology, registry, SARS‐CoV‐2, 03 medical and health sciences, 0302 clinical medicine, COVID‐19, Informed consent, Pandemic, medicine, Humans, In patient, Registries, 030212 general & internal medicine, Pandemics, SARS-CoV-2, business.industry, Incidence (epidemiology), Public health, COVID-19, Neurointensive care, Original Articles, EAN, neurological diseases, outcome, Emergency medicine, Original Article, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

The COVID‐19 pandemic is a global public health issue. Neurological complications have been reported in up to one‐third of affected cases, but their distribution varies significantly in terms of prevalence, incidence and phenotypical characteristics. Variability can be mostly explained by the differing sources of cases (hospital vs. community‐based), the accuracy of the diagnostic approach, and the interpretation of the patients’ complaints. Moreover, after recovering, patients can still experience neurological symptoms. To obtain a more precise picture of the neurological manifestations and outcome of the COVID‐19 infection, an international registry (ENERGY) has been created by the European Academy of Neurology (EAN) in collaboration with European national neurological societies and the Neurocritical Care Society and Research Network (NCRN). ENERGY can be implemented as a stand‐alone instrument for patients with suspected or confirmed COVID‐19 patients AND neurological findings or as an addendum to an existing registry not targeting neurologic symptoms. Data are also collected to study the impact of neurological symptoms and neurological complications on outcomes. The variables included in the registry have been selected in the interest of most countries, to favour pooling with data from other sources, and to facilitate data collection even in resource‐poor countries. Included are adults with suspected or confirmed COVID‐19 infection, ascertained through neurological consultation, and providing informed consent. Key demographic and clinical findings are collected at registration. Patients are followed up to 12 months in search of incident neurological manifestations. As of August 19, 254 centres from 69 countries and four continents have made requests to join the study.

Published
2021

37. COVID-19 vaccination hesitancy among people with chronic neurological disorders: A position paper

Author

Rakusa, Martin, Ozturk, Serefnur, Moro, Elena, Helbok, Raimund, Bassetti, Claudio L., Beghi, Ettore, Bereczki, Daniel, Bodini, Benedetta, Di Liberto, Giovanni, Jenkins, Thomas M., Macerollo, Antonella, Maia, Luis F., Martinelli-Boneschi, Filippo, Pisani, Antonio, Priori, Alberto, Sauerbier, Anna, Soffietti, Riccardo, Taba, Pille, von Oertzen, Tim J., Zedde, Marialuisa, Crean, Michael, Burlica, Anja, Cavallieri, Francesco, Sellner, Johann, Rakusa, Martin, Ozturk, Serefnur, Moro, Elena, Helbok, Raimund, Bassetti, Claudio L., Beghi, Ettore, Bereczki, Daniel, Bodini, Benedetta, Di Liberto, Giovanni, Jenkins, Thomas M., Macerollo, Antonella, Maia, Luis F., Martinelli-Boneschi, Filippo, Pisani, Antonio, Priori, Alberto, Sauerbier, Anna, Soffietti, Riccardo, Taba, Pille, von Oertzen, Tim J., Zedde, Marialuisa, Crean, Michael, Burlica, Anja, Cavallieri, Francesco, and Sellner, Johann

Abstract

Background and purpose Health risks associated with SARS-CoV-2 infection are undisputed. Moreover, the capability of vaccination to prevent symptomatic, severe, and fatal COVID-19 is recognized. There is also early evidence that vaccination can reduce the chance for long COVID-19. Nonetheless, the willingness to get vaccinated and receive booster shots remains subpar among people with neurologic disorders. Vaccine scepticism not only jeopardizes collective efforts to end the COVID-19 pandemic but puts individual lives at risk, as some chronic neurologic diseases are associated with a higher risk for an unfavorable COVID-19 course. Methods In this position paper, the NeuroCOVID-19 Task Force of the European Academy of Neurology (EAN) summarizes the current knowledge on the prognosis of COVID-19 among patients with neurologic disease, elucidates potential barriers to vaccination coverage, and formulates strategies to overcome vaccination hesitancy. A survey among the Task Force members on the phenomenon of vaccination hesitancy among people with neurologic disease supports the lines of argumentation. Results The study revealed that people with multiple sclerosis and other nervous system autoimmune disorders are most skeptical of SARS-CoV-2 vaccination. The prevailing concerns included the chance of worsening the pre-existing neurological condition, vaccination-related adverse events, and drug interaction. Conclusions The EAN NeuroCOVID-19 Task Force reinforces the key role of neurologists as advocates of COVID-19 vaccination. Neurologists need to argue in the interest of their patients about the overwhelming individual and global benefits of COVID-19 vaccination. Moreover, they need to keep on eye on this vulnerable patient group, its concerns, and the emergence of potential safety signals.

Published
2022

38. Brief Consent Methods Enable Rapid Enrollment in Acute Stroke Trial:Results From the TICH-2 Randomized Controlled Trial

Author

Law, Zhe Kang, Appleton, Jason P., Scutt, Polly, Roberts, Ian, Al-Shahi Salman, Rustam, England, Timothy J., Werring, David J., Robinson, Thompson, Krishnan, Kailash, Dineen, Robert A., Laska, Ann Charlotte, Lyrer, Philippe A., Egea-Guerrero, Juan Jose, Karlinski, Michal, Christensen, Hanne, Roffe, Christine, Bereczki, Daniel, Ozturk, Serefnur, Thanabalan, Jegan, Collins, Ronan, Beridze, Maia, Ciccone, Alfonso, Duley, Lelia, Shone, Angela, Bath, Philip M., Sprigg, Nikola, Law, Zhe Kang, Appleton, Jason P., Scutt, Polly, Roberts, Ian, Al-Shahi Salman, Rustam, England, Timothy J., Werring, David J., Robinson, Thompson, Krishnan, Kailash, Dineen, Robert A., Laska, Ann Charlotte, Lyrer, Philippe A., Egea-Guerrero, Juan Jose, Karlinski, Michal, Christensen, Hanne, Roffe, Christine, Bereczki, Daniel, Ozturk, Serefnur, Thanabalan, Jegan, Collins, Ronan, Beridze, Maia, Ciccone, Alfonso, Duley, Lelia, Shone, Angela, Bath, Philip M., and Sprigg, Nikola

Abstract

Background: Seeking consent rapidly in acute stroke trials is crucial as interventions are time sensitive. We explored the association between consent pathways and time to enrollment in the TICH-2 (Tranexamic Acid in Intracerebral Haemorrhage-2) randomized controlled trial. Methods: Consent was provided by patients or by a relative or an independent doctor in incapacitated patients, using a 1-stage (full written consent) or 2-stage (initial brief consent followed by full written consent post-randomization) approach. The computed tomography-to-randomization time according to consent pathways was compared using the Kruskal-Wallis test. Multivariable logistic regression was performed to identify variables associated with onset-to-randomization time of ≤3 hours. Results: Of 2325 patients, 817 (35%) gave self-consent using 1-stage (557; 68%) or 2-stage consent (260; 32%). For 1507 (65%), consent was provided by a relative (1 stage, 996 [66%]; 2 stage, 323 [21%]) or a doctor (all 2-stage, 188 [12%]). One patient did not record prerandomization consent, with written consent obtained subsequently. The median (interquartile range) computed tomography-to-randomization time was 55 (38-93) minutes for doctor consent, 55 (37-95) minutes for 2-stage patient, 69 (43-110) minutes for 2-stage relative, 75 (48-124) minutes for 1-stage patient, and 90 (56-155) minutes for 1-stage relative consents (P<0.001). Two-stage consent was associated with onset-to-randomization time of ≤3 hours compared with 1-stage consent (adjusted odds ratio, 1.9 [95% CI, 1.5-2.4]). Doctor consent increased the odds (adjusted odds ratio, 2.3 [1.5-3.5]) while relative consent reduced the odds of randomization ≤3 hours (adjusted odds ratio, 0.10 [0.03-0.34]) compared with patient consent. Only 2 of 771 patients (0.3%) in the 2-stage pathways withdrew consent when full consent was sought later. Two-stage consent process did not result in higher withdrawal rates or loss to follow-up. Conclusions: The use o

Published
2022

39. Risk for Major Bleeding in Patients Receiving Ticagrelor Compared With Aspirin After Transient Ischemic Attack or Acute Ischemic Stroke in the SOCRATES Study (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes)

Author

Easton, J. Donald, Aunes, Maria, Albers, Gregory W., Amarenco, Pierre, Bokelund-Singh, Sara, Denison, Hans, Evans, Scott R., Held, Peter, Jahreskog, Marianne, Jonasson, Jenny, Minematsu, Kazuo, Molina, Carlos A., Wang, Yongjun, Wong, K.S. Lawrence, Johnston, S. Claiborne, Ameriso, Sebastiá F., Donnan, Geoffrey, Lemmens, Robin, Massaro, Ayrton, Titianova, Ekaterina, Hill, Michael D., Lavados, Pablo, Skoloudik, David, Röther, Joachim, Norbert, Szegedi, Agnelli, Giancarlo, Bornstein, Natan, Tanahashi, Norio, Góngora, Angel Arauz, Pretell, Edwin, San Jose, Maria Cristina Z., Czlonkowska, Anna, Bajenaru, Ovidiu, Stakhovskaya, Ludmila, Brozman, Miroslav, Kim, Jong-Sung, Wahlgren, Nils, Michel, Patrik, Lee, Tsong Hai, Suwanwela, Nijasri Charnnarong, Kutluk, Kursad, Moskovko, Sergii, Kasner, Scott, Laskowitz, Daniel, Clark, Wayne, Nguyen, Huy Thang, Ameriso, Sebastian, Lepera, Sandra, Romano, Marina, Paulon, David, Ioli, Pablo, Zurru, Cristina, Bruera, Guadalupe, Jure, Lorena, Klein, Francisco, Povedano, Guillermo, Levi, Christopher, Phan, Thanh, Markus, Romesh, Anderson, Craig, Sabet, Arman, Davis, Stephen, Lee, Andrew, Kleinig, Timothy, Wong, Andrew, Krause, Martin, Jannes, Jim, Wijeratne, Tissa, Lemmens, Robin, Hemelsoet, Dimitri, Peeters, André, Tack, Philippe, Vanacker, Peter, Laloux, Patrice, Van Landegem, William, Vanhooren, Geert, Desfontaines, Philippe, Van Orshoven, Marc, Oliveira, Fabio, Friedrich, Mauricio, Brondani, Rosane, Gagliardi, Rubens, Fabio, Soraia, Dracoulakis, Marianna, Bazan, Rodrigo, Marrone, Luiz, Pontes Neto, Octavio, Silva, Gisele, Kowacs, Pedro, Titianova, Ekaterina, Stamenova, Paraskeva, Daskalov, Marin, Staikov, Ivan, Baldaranov, Dimo, Maslarov, Dimitar, Lilovski, Hristo, Petkov, Plamen, Petrova, Neli, Mavrov, Radoslav, Markova, Veska, Petrova, Valeria, Beleva, Tanya, Kralev, Borislav, Sotirov, Nikolay, Lekova, Veska, Hristov, Dimcho, Ermenkova, Vera, Mateev, Lyudmil, Mitkova, Rumeliya, Haralanov, Liybomir, Ikonomov, Rosen, Mihailova, Margarita, Georgiev, Ivan, Shuaib, Ashfaq, Hachinski, Vladimir, Boulanger, Jean-Martin, Mann, Sharan, Hassan, Ayman, Mackey, Ariane, Menon, Bijoy, Minuk, Jeffrey, Siddiqui, Muzaffar, Eustace, Marsha, Vieira, Lucia, Selchen, Daniel, Beaudry, Michel, Stotts, Grant, Lavados, Pablo, Castro, Angel, Gasic, Kristo, Rivas, Rodrigo, Sanchez, Pablo, Roldan, Andres, Grossmann, Ingrid, Figueroa, Christian, Li, Jimei, Xu, Xiaolin, Chen, Huisheng, Li, Xiaohong, Yang, Yi, Zhang, Chunsheng, Wang, Baojun, Li, Guanglai, Wang, Dong, Lin, Hong, Tang, Yamei, Xu, Anding, Wang, Yanjiang, Hong, Wenke, Song, Zhi, Zhang, Xu, Jin, Xiaoping, Xu, Yun, Yan, Fuling, Zheng, Weihong, Wang, Xiaoping, Dong, Qiang, Zhao, Zhongxin, Zhang, Baorong, Zhong, Wangtao, Wen, Guoqiang, Xu, Jun, Li, Guozhong, Dong, Xueshuang, Tian, Xiangyang, Zhang, Zhaohui, Xu, En, Liu, Kaixiang, Chen, Jun, Skoda, Ondrej, Skoloudik, David, Ehler, Edvard, Vaclavik, Daniel, Sanak, Daniel, Klimosova, Sylva, Vitkova, Eva, Fiksa, Jan, Mikulik, Robert, Neumann, Jiri, Plny, Richard, Leys, Didier, Sibon, Igor, Mas, Jean-Louis, Alamowitch, Sonia, Pico, Fernando, Hosseini, Hassan, Mahagne, Marie-Hélène, Touze, Emmanuel, Vadot, Wilfried, Vannier, Stéphane, Nighoghossian, Norbert, Samson, Yves, Garnier, Pierre, Ellie, Emmanuel, Guillon, Benoît, Timsit, Serge, Giroud, Maurice, Philippeau, Frédéric, Bagan-Triquenot, Aude, Wolff, Valérie, Raposo, Nicolas, Obadia, Michel, Debiais, Severine, Grimaud, Jérôme, Illouz, Stéphane, Smadja, Didier, Urbanczyk, Cédric, Röther, Joachim, Berrouschot, Jörg, Weimar, Christian, Gahn, Georg, Soda, Hassan, Klimpe, Sven, Nabavi, Darius, Glahn, Jörg, Köhrmann, Martin, Krause, Lars, Terborg, Christoph, Urban, Peter, Steiner, Thorsten, Ferbert, Andreas, Dziewas, Rainer, Seidel, Günter, Thomalla, Götz, Li, Richard, Fong, Wing Chi, Cheung, Raymond, Szegedi, Norbert, Pozsegovits, Krisztián, Valikovics, Attila, Pánczél, Gyula, Rózsa, Csilla, Németh, László, Diószeghy, Péter, Óváry, Csaba, Csányi, Attila, Kerényi, Levente, Nagy, Valéria, Komoly, Sámuel, Bereczki, Dániel, Molnár, Sándor, Kondákor, István, Tanne, David, Raphaeli, Guy, Telman, Gregory, Bornstein, Natan, Leker, Ronen, Lampl, Yair, Agnelli, Giancarlo, Corea, Francesco, Ricci, Stefano, Guidetti, Donata, Malferrari, Giovanni, Marcheselli, Simona, Micieli, Giuseppe, Zini, Andrea, Di Lazzaro, Vincenzo, Gandolfo, Carlo, Salmaggi, Andrea, Tassi, Rossana, Rasura, Maurizia, Orlandi, Giovanni, Comi, Giancarlo, Ricci, Stefano, Mancuso, Michelangelo, Delodovici, Marialuisa, Bovi, Paolo, Consoli, Domenico, Utsugisawa, Kimiaki, Fujita, Tsuneo, Kurihara, Hideyuki, Maruki, Chikashi, Hayashi, Takeshi, Ogiichi, Tsuneaki, Kumagai, Morio, Takenaka, Katsunobu, Toyoda, Kazunori, Takamatsu, Kazuhiro, Ogami, Ryo, Kin, Shigenari, Aoki, Takeshi, Takizawa, Katsumi, Omori, Shigehiro, Umezawa, Takehiko, Toba, Yasuyuki, Nonoyama, Yutaka, Nakagawa, Hidemitsu, Naka, Takashi, Morimoto, Masanori, Matsumoto, Shuichi, Hitotsumatsu, Tsutomu, Shingaki, Tatsuya, Okuda, Satoshi, Ota, Mamoru, Sakai, Nobuyuki, Yamada, Takeshi, Niwa, Jun, Fujita, Hitoshi, Moriki, Akihito, Yoshino, Kimihiro, Fukushima, Yoshihisa, Mori, Takahisa, Sato, Atsushi, Kusano, Yoshikazu, Kubo, Michiya, Yamazaki, Masashi, Ooasa, Takao, Nishizaki, Takafumi, Kitagawa, Naoki, Yasaka, Masahiro, Manabe, Yasuhiro, Yoshioka, Akira, Ishihara, Masayuki, Kagawa, Takato, Ichihashi, Toshikazu, Matsuoka, Hideki, Ito, Yasuhiro, Yamasaki, Masahiro, Takaba, Hitonori, Saito, Hisatoshi, Sato, Masahiro, Fukuda, Kazumasa, Endo, Sumio, Kidooka, Minoru, Umemura, Toshitaka, Kikkawa, Yuriko, Toru, Shuta, Yamada, Kentaro, Sakai, Hideki, Asari, Jun, Ezura, Masayuki, Nitta, Hisashi, Nagano, Keiko, Ochiai, Jun, Sakai, Keiichi, Kobayashi, Yasutaka, Yoshii, Yasuhiro, Miake, Hirotomo, Takita, Tomohiro, Taniguchi, Hidekazu, Kuroki, Kazuhiko, Mizota, Takamitsu, Yamamoto, Kenichi, Nakane, Hiroshi, Iwanaga, Takeshi, Chiba, Kei, Yoshimoto, Tetsuyuki, Torii, Tsuyoshi, Kitagawa, Takeo, Takashima, Hiroshi, Shirasaki, Naoki, Dehara, Makoto, Wada, Naomichi, Hamada, Kensuke, Kato, Noriyuki, Go, Yoshinori, Izumi, Ichiro, Ninomiya, Hirotomo, Kumai, Junichiro, Nakajima, Yoshikazu, Kaku, Yasuhiko, Isayama, Yukihiro, Kawanishi, Masahiro, Noda, Shinya, Yamamoto, Kazuhide, Hazama, Takanori, Takahashi, Hiroshi, Tanaka, Yohei, Hata, Takashi, Kazekawa, Kiyoshi, Furui, Eisuke, Hondo, Hideki, Sato, Nobuyuki, Kusunoki, Katsusuke, Nanri, Kazunori, Abe, Satoshi, Sasaoka, Noboru, Kuroyanagi, Takayuki, Suzuki, Hisahiko, Fukuyama, Kouzou, Nakahara, Kimihiro, Gongora, Fernando, Góngora, Angel Arauz, Cantú Brito, Carlos, Villarreal Careaga, Jorge, Vazquez Alfaro, Rosalia, Aguayo Leytte, Geronimo, Berrospi, Percy, Chavez, Carlos, Pretell, Edwin, Rodriguez, Liliana, Custodio, Nilton, Castañeda, Cesar, Perez, Julio, San Jose, Maria Cristina, Baroque, Alejandro, Collantes, Epifania, Aquino, Abdias, Díaz, Alejandro, Roxas, Artemio, Jr, Lokin, Johnny, Advincula, Joel, Calderon, Emerito, Navarro, Jose, Hiyadan, John, Surdilla, Arturo, Czlonkowska, Anna, Ryglewicz, Danuta, Krychowiak, Grzegorz, Fryze, Waldemar, Sobolewski, Piotr, Nowak, Ryszard, Fiszer, Urszula, Papierowska, Beata, Zielińska-Turek, Justyna, Lasek-Bal, Anetta, Kołodziejska, Ewa, Kamińska, Anna, Adamkiewicz, Bożena, Tutaj, Andrzej, Szkopek, Dorota, Musiatowicz, Krzysztof, Bąk, Zbigniew, Brzozowski, Sławomir, Brola, Waldemar, Ferens, Antoni, Zalisz, Marek, Rejdak, Konrad, Rudzińska, Monika, Bajenaru, Ovidiu, Panea, Cristina, Simu, Mihaela, Balasa, Rodica, Cuciureanu, Iulian, Popescu, Bogdan, Sabau, Monica, Roman-Filip, Corina, Pimenov, Leonid, Gekht, Alla, Milto, Anna, Shchukin, Ivan, Parfenov, Vladimir, Stakhovskaya, Liudmila, Arkhipov, Mikhail, Sokolova, Nadezhda, Bogdanov, Enver, Esin, Radiy, Khasanova, Dina, Golikov, Konstantin, Melnikova, Elena, Zaslavskiy, Leonid, Voznyuk, Igor, Nazarov, Alexander, Akhmadeeva, Leila, Iakupova, Aida, Shamalov, Nikolay, Belskaya, Galina, Chuprina, Svetlana, Denisova, Olga, Drozdova, Ekaterina, Karakulova, Yuliya, Sholomov, Ilya, Spirin, Nikolay, Vostrikova, Elena, Mordvintseva, Elena, Grigoryeva, Vera, Zateyshchikov, Dmitry, Gorbachev, Vladimir, Chefranova, Zhanna, Dudarev, Mikhail, Nilk, Rostislav, Rozhdestvenskiy, Alexey, Gurcik, Ladislav, Dvorak, Miloslav, Krastev, Georgi, Kurca, Egon, Vyletelka, Juraj, Brozman, Miroslav, Kim, Jong Sung, Bae, Hee-Joon, Kim, Yong-Won, Kim, Joon-Tae, Cha, Jae-Kwan, Nam, Hyo Suk, Chang, Dae-Il, Lee, Yong-Seok, Oh, Kyungmi, Yu, Sung-Wook, Sohn, Sung-Il, Lee, Jun, Cho, Han Jin, Kim, Eung-Gyu, Rha, Joung-Ho, Kim, Seo Hyun, Molina Cateriano, Carlos, Serena Leal, Joaquín, Vivancos Mora, José, Rodríguez Yañez, Manuel, Roquer González, Jaume, Purroy García, Francisco, Gomis Cortina, Meritxell, Masjuan Vallejo, Jaime, Arenillas Lara, Juan, Segura Martín, Tomás, Herrero, José Antonio Egido, Tembl Ferrairó, Jose Ignacio, Gállego Culleré, Jaime, Moniche Álvarez, Francisco, Steinberg, Anna, Callander, Margarita, Laska, Ann Charlotte, Bokemark, Lena, Mooe, Thomas, Käll, Tor-Björn, Welin, Lennart, Sjöblom, Lars, Hambraeus, Joakim, Teichert, Jörg, Wannberg, Hans, Sanner, Johan, Ramströmer, Bo, Ziedén, Bo, Hau, Stefan Olsson, Gustafsson, Claes, Michel, Patrik, Kahles, Timo, Lyrer, Philippe, Arnold, Marcel, Liesch, Martin, Medlin, Friedrich, Cereda, Carlo, Kägi, Georg, Luft, Andreas, Carrera, Emmanuel, Lee, Tsong-Hai, Po, Helen L., Chern, Chang-Ming, Lien, Li-Ming, Chan, Lung, Liu, Chung-Hsiang, Wu, Shey-Lin, Lee, Jiann-Der, Chen, Chih-Hung, Lin, Huey-Juan, Lin, Ruey-Tay, Chen, Wei-Hsi, Sun, Yu, Suwanwela, Nijasri Charnnarong, Tantirittisak, Tasanee, Muengtaweepongsa, Sombat, Nilanont, Yongchai, Tiamkao, Somsak, Udommongkol, Chesda, Watcharasaksilp, Kanokwan, Jantararotai, Witoon, Kutluk, Kursad, Sirin, Hadiye, Ince, Birsen, Asil, Talip, Arsava, Murat, Incesu, Tulay Kurt, Tireli, Hulya, Kucukoglu, Hayriye, Ak, Fikri, Unal, Ali, Ozturk, Serefnur, Uzuner, Nevzat, Chmyr, Galyna, Lebedynets, Volodymyr, Nikonov, Vadym, Shulga, Lyudmyla, Smolanka, Volodymyr, Moskovko, Sergii, Khavunka, Marta, Yavorska, Valentyna, Tomakh, Nataliya, Kozyolkin, Olexandr, Litovaltseva, Galyna, Lansberg, Maarten, Bernstein, Richard, Brown, David, Clark, Wayne, Dissin, Jonathan, Graffagnino, Carmelo, Harris, Jonathan, Hicks, William, Kasner, Scott, Katzan, Irene, Kramer, Jeffrey, Willey, Joshua, Silliman, Scott, Starkman, Sidney, Thaler, David, Tremwel, Margaret, Concha, Mauricio, Rajamani, Kumar, Dandapani, Bhuvaneswari, Silver, Brian, Deal, Nathan, Chang, Ira, Hassan, Ameer, Rudolph, Steven, Fischer, Kenneth, Kirshner, Howard, Logan, William, Mallenbaum, Sidney, Hefzy, Hebah, Latorre, Julius, Levine, Steven, Ciabarra, Anthony, Dafer, Rima, Anyanwu, Benjamin, Cherian, Laurel, Panezai, Spozhmy, Khanna, Anna, Dodds, Jodi, Torbey, Michel, Gebel, James, Woo, Henry, Chiu, David, Androulakis, Xiao, Burgin, William, Pineda, Maria, Yilmaz, Engin, Altafullah, Irfan, Boutwell, Christine, Cruz-Flores, Salvador, Sapkota, Biggya, Fayad, Pierre, Jacoby, Michael, Rafiq, Shahid, Salgado, Efrain, Lafranchise, Eugene, Felton, Warren, Madhavan, Ramesh, Zaidat, Osama, Pieper, Connie, Riviello, Ralph, Burnett, Aaron, Fischer, Michelle, Gentile, Nina, Calder, Christopher, Dietrich, Dennis, Cross, Jonathan, Blankenship, Larry, Dafer, Rima, Montoya, Liliana, Grogan, Wendell, Young, Mark, Khan, Farrukh, Campbell, Duane, Daboul, Nizar, Espinoza, Andrey, Cullis, Paul, Concepcion, Gilberto, Wulff, John, Afzal, Haider, Jaffrani, Naseem, Reiter, William, Arshad, Tamjeed, Lukovits, Timothy, Welker, James, Chang, Fen Lei, Badruddin, Aamir, Babikian, Viken, Menon, Ravi, Sander, James, Springer, Mellanie, Nanda, Ashish, Mas, Luis, Rajan, Raj, Silverman, Bruce, Hefzy, Hebah, Huang, David, Carpenter, David, Clark, Joni, Ching, Marilou, Santhakumar, Sunitha, Gould, Jeffrey, Bansal, Vibhav, Vidal, Gabriel, Mikesell, Timothy, Brick, John, French, William, Shah, Qaisar, Holmstedt, Christine, Ishag-Osman, Nadir, Kostis, John, Shehadeh, Abbas, Sethi, Pramodkumak, Imam, Asher, Mccomas, Carl, Tran, Duc, Gebreyohanns, Mehari, Wiseman, Brian, Malik, Maheen, Schwarcz, Aron, Altschul, Dorothea, Castaldo, John, Alshekhlee, Amer, Gancher, Stephen, Krish, Nagesh, Nguyen-Huynh, Mai, Tremwell, Margaret, Sharma, Jitendra, Lee, Lance, Neil, William, Siddiqui, Fazeel, Malek, Ali, Romero, Charles, Huy, Thang Nguyen, Hoang, Hoa, Nguyen, Thang, Nguyen, Anh, and Nguyen, Hung

Published
2017
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41. Primary stroke prevention worldwide:translating evidence into action

Author

Owolabi, Mayowa O., Thrift, Amanda G., Mahal, Ajay, Ishida, Marie, Martins, Sheila, Johnson, Walter D., Pandian, Jeyaraj, Abd-Allah, Foad, Yaria, Joseph, Phan, Hoang T., Roth, Greg, Gall, Seana L., Beare, Richard, Phan, Thanh G., Mikulik, Robert, Akinyemi, Rufus O., Norrving, Bo, Brainin, Michael, Feigin, Valery L., Abanto, Carlos, Abera, Semaw Ferede, Addissie, Adamu, Adebayo, Oluwadamilola, Adeleye, Amos Olufemi, Adilbekov, Yerzhan, Adilbekova, Bibigul, Adoukonou, Thierry Armel, Aguiar de Sousa, Diana, Ajagbe, Temitope, Akhmetzhanova, Zauresh, Akpalu, Albert, Álvarez Ahlgren, Jhon, Ameriso, Sebastián, Andonova, Silva, Awoniyi, Foloruso Emmanuel, Bakhiet, Moiz, Barboza, Miguel, Basri, Hamidon, Bath, Philip, Bello, Olamide, Bereczki, Dániel, Beretta, Simone, Berkowitz, Aaron, Bernabé-Ortiz, Antonio, Bernhardt, Julie, Berzina, Guna, Bisharyan, Mher, Bovet, Pascal, Budincevic, Hrvoje, Cadilhac, Dominique, Caso, Valeria, Chen, Christopher, Chin, Jerome, Chwojnicki, Kamil, Conforto, Adriana, Cruz, Vitor Tedim, D'Amelio, Marco, Danielyan, Kristine, Davis, Stephen, Demarin, Vida, Dempsey, Robert, Dichgans, Martin, Dokova, Klara, Donnan, Geoffrey, Elkind, Mitchell S., Endres, Matthias, Fischer, Urs, Gankpé, Fortuné, Gaye Saavedra, Andrés, Gil, Artyom, Giroud, Maurice, Gnedovskaya, Elena, Hachinski, Vladimir, Hafdi, Melanie, Hamadeh, Randah, Hamzat, T. Kolapo, Hankey, Graeme, Heldner, Mirjam, Ibrahim, Etedal Ahmed, Ibrahim, Norlinah Mohamed, Inoue, Manabu, Jee, Sungju, Jeng, Jiann-Shing, Kalkonde, Yogesh, Kamenova, Saltanat, Karaszewski, Bartosz, Kelly, Peter, Khan, Taskeen, Kiechl, Stefan, Kondybayeva, Aida, Kõrv, Janika, Kravchenko, Michael, Krishnamurthi, Rita V., Kruja, Jera, Lakkhanaloet, Mongkol, Langhorne, Peter, Lavados, Pablo M., Law, Zhe Kang, Lawal, Abisola, Lazo-Porras, Maria, Lebedynets, Dmytro, Lee, Tsong-Hai, Leung, Thomas, Liebeskind, David S., Lindsay, Patrice, López-Jaramillo, Patricio, Lotufo, Paulo Andrade, Machline-Carrion, Julia, Makanjuola, Akintomiwa, Markus, Hugh Stephen, Marquez-Romero, Juan Manuel, Medina, Marco, Medukhanova, Sabina, Mehndiratta, Man Mohan, Merkin, Alexandr, Mirrakhimov, Erkin, Mohl, Stephanie, Moscoso-Porras, Miguel, Müller-Stierlin, Annabel, Murphy, Sean, Musa, Kamarul Imran, Nasreldein, Ahmed, Nogueira, Raul Gomes, Nolte, Christian, Noubiap, Jean Jacques, Novarro-Escudero, Nelson, Ogun, Yomi, Oguntoye, Richard Ayobami, Oraby, Mohammed Ibrahim, Osundina, Morenike, Ovbiagele, Bruce, Orken, Dilek Necioglu, Ozdemir, Atilla Özcan, Ozturk, Serefnur, Paccot, Melanie, Phromjai, Jurairat, Piradov, Piradov, Platz, Thomas, Potpara, Tatjana, Ranta, Annemarei, Rathore, Farooq, Richard, Edo, Sacco, Ralph L., Sahathevan, Ramesh, Santos Carquín, Irving, Saposnik, Gustavo, Sarfo, Fred Stephen, Sharma, Mike, Sheth, Kevin, Shobhana, A., Suwanwela, Nijasri, Svyato, Irina, Sylaja, P.N., Tao, Xuanchen, Thakur, Kiran T., Toni, Danilo, Topcuoglu, Mehmet Akif, Torales, Julio, Towfighi, Amytis, Truelsen, Thomas Clement, Tsiskaridze, Alexander, Tulloch-Reid, Marshall, Useche, Nicolás, Vanacker, Peter, Vassilopoulou, Sophia, Vukorepa, Gorana, Vuletic, Vladimira, Wahab, Kolawole W., Wang, Wenzhi, Wijeratne, Tissa, Wolfe, Charles, Yifru, Yared Mamushet, Yock-Corrales, Adriana, Yonemoto, Naohiro, Yperzeele, Laetitia, Zhang, Puhong, Oguntoye, Stroke Experts Collaboration Group, Owolabi M.O., Thrift A.G., Mahal A., Ishida M., Martins S., Johnson W.D., Pandian J., Abd-Allah F., Yaria J., Phan H.T., Roth G., Gall S.L., Beare R., Phan T.G., Mikulik R., Akinyemi R.O., Norrving B., Brainin M., Feigin V.L., Abanto C., Abera S.F., Addissie A., Adebayo O., Adeleye A.O., Adilbekov Y., Adilbekova B., Adoukonou T.A., Aguiar de Sousa D., Ajagbe T., Akhmetzhanova Z., Akpalu A., Alvarez Ahlgren J., Ameriso S., Andonova S., Awoniyi F.E., Bakhiet M., Barboza M., Basri H., Bath P., Bello O., Bereczki D., Beretta S., Berkowitz A., Bernabe-Ortiz A., Bernhardt J., Berzina G., Bisharyan M., Bovet P., Budincevic H., Cadilhac D., Caso V., Chen C., Chin J., Chwojnicki K., Conforto A., Cruz V.T., D'Amelio M., Danielyan K., Davis S., Demarin V., Dempsey R., Dichgans M., Dokova K., Donnan G., Elkind M.S., Endres M., Fischer U., Gankpe F., Gaye Saavedra A., Gil A., Giroud M., Gnedovskaya E., Hachinski V., Hafdi M., Hamadeh R., Hamzat T.K., Hankey G., Heldner M., Ibrahim E.A., Ibrahim N.M., Inoue M., Jee S., Jeng J.-S., Kalkonde Y., Kamenova S., Karaszewski B., Kelly P., Khan T., Kiechl S., Kondybayeva A., Korv J., Kravchenko M., Krishnamurthi R.V., Kruja J., Lakkhanaloet M., Langhorne P., Lavados P.M., Law Z.K., Lawal A., Lazo-Porras M., Lebedynets D., Lee T.-H., Leung T., Liebeskind D.S., Lindsay P., Lopez-Jaramillo P., Lotufo P.A., Machline-Carrion J., Makanjuola A., Markus H.S., Marquez-Romero J.M., Medina M., Medukhanova S., Mehndiratta M.M., Merkin A., Mirrakhimov E., Mohl S., Moscoso-Porras M., Muller-Stierlin A., Murphy S., Musa K.I., Nasreldein A., Nogueira R.G., Nolte C., Noubiap J.J., Novarro-Escudero N., Ogun Y., Oguntoye R.A., Oraby M.I., Osundina M., Ovbiagele B., Orken D.N., Ozdemir A.O., Ozturk S., Paccot M., Phromjai J., Piradov P., Platz T., Potpara T., Ranta A., Rathore F., Richard E., Sacco R.L., Sahathevan R., Santos Carquin I., Saposnik G., Sarfo F.S., Sharma M., Sheth K., Shobhana A., Suwanwela N., Svyato I., Sylaja P.N., Tao X., Thakur K.T., Toni D., Topcuoglu M.A., Torales J., Towfighi A., Truelsen T.C., Tsiskaridze A., Tulloch-Reid M., Useche N., Vanacker P., Vassilopoulou S., Vukorepa G., Vuletic V., Wahab K.W., Wang W., Wijeratne T., Wolfe C., Yifru Y.M., Yock-Corrales A., Yonemoto N., Yperzeele L., and Zhang P.

Subjects
Global Burden of Disease, 03 medical and health sciences, 0302 clinical medicine, Nursing, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Neurology, Medicine, 030212 general & internal medicine, Stroke, Health policy, Cause of death, Entire population, Health professionals, business.industry, Health Policy, Public Health, Environmental and Occupational Health, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Neurologija, medicine.disease, 3. Good health, Action (philosophy), Stroke prevention, Occlusive Cerebrovascular Disease, Life course approach, Human medicine, business, 030217 neurology & neurosurgery
Abstract

Stroke is the second leading cause of death and the third leading cause of disability worldwide and its burden is increasing rapidly in low-income and middle-income countries, many of which are unable to face the challenges it imposes. In this Health Policy paper on primary stroke prevention, we provide an overview of the current situation regarding primary prevention services, estimate the cost of stroke and stroke prevention, and identify deficiencies in existing guidelines and gaps in primary prevention. We also offer a set of pragmatic solutions for implementation of primary stroke prevention, with an emphasis on the role of governments and population-wide strategies, including task-shifting and sharing and health system re-engineering. Implementation of primary stroke prevention involves patients, health professionals, funders, policy makers, implementation partners, and the entire population along the life course.

Published
2022

43. Primary stroke prevention worldwide: translating evidence into action

Author

Owolabi, Mayowa O, primary, Thrift, Amanda G, additional, Mahal, Ajay, additional, Ishida, Marie, additional, Martins, Sheila, additional, Johnson, Walter D, additional, Pandian, Jeyaraj, additional, Abd-Allah, Foad, additional, Yaria, Joseph, additional, Phan, Hoang T, additional, Roth, Greg, additional, Gall, Seana L, additional, Beare, Richard, additional, Phan, Thanh G, additional, Mikulik, Robert, additional, Akinyemi, Rufus O, additional, Norrving, Bo, additional, Brainin, Michael, additional, Feigin, Valery L, additional, Abanto, Carlos, additional, Abera, Semaw Ferede, additional, Addissie, Adamu, additional, Adebayo, Oluwadamilola, additional, Adeleye, Amos Olufemi, additional, Adilbekov, Yerzhan, additional, Adilbekova, Bibigul, additional, Adoukonou, Thierry Armel, additional, Aguiar de Sousa, Diana, additional, Ajagbe, Temitope, additional, Akhmetzhanova, Zauresh, additional, Akpalu, Albert, additional, Álvarez Ahlgren, Jhon, additional, Ameriso, Sebastián, additional, Andonova, Silva, additional, Awoniyi, Foloruso Emmanuel, additional, Bakhiet, Moiz, additional, Barboza, Miguel, additional, Basri, Hamidon, additional, Bath, Philip, additional, Bello, Olamide, additional, Bereczki, Dániel, additional, Beretta, Simone, additional, Berkowitz, Aaron, additional, Bernabé-Ortiz, Antonio, additional, Bernhardt, Julie, additional, Berzina, Guna, additional, Bisharyan, Mher, additional, Bovet, Pascal, additional, Budincevic, Hrvoje, additional, Cadilhac, Dominique, additional, Caso, Valeria, additional, Chen, Christopher, additional, Chin, Jerome, additional, Chwojnicki, Kamil, additional, Conforto, Adriana, additional, Cruz, Vitor Tedim, additional, D'Amelio, Marco, additional, Danielyan, Kristine, additional, Davis, Stephen, additional, Demarin, Vida, additional, Dempsey, Robert, additional, Dichgans, Martin, additional, Dokova, Klara, additional, Donnan, Geoffrey, additional, Elkind, Mitchell S., additional, Endres, Matthias, additional, Fischer, Urs, additional, Gankpé, Fortuné, additional, Gaye Saavedra, Andrés, additional, Gil, Artyom, additional, Giroud, Maurice, additional, Gnedovskaya, Elena, additional, Hachinski, Vladimir, additional, Hafdi, Melanie, additional, Hamadeh, Randah, additional, Hamzat, T. Kolapo, additional, Hankey, Graeme, additional, Heldner, Mirjam, additional, Ibrahim, Etedal Ahmed, additional, Ibrahim, Norlinah Mohamed, additional, Inoue, Manabu, additional, Jee, Sungju, additional, Jeng, Jiann-Shing, additional, Kalkonde, Yogesh, additional, Kamenova, Saltanat, additional, Karaszewski, Bartosz, additional, Kelly, Peter, additional, Khan, Taskeen, additional, Kiechl, Stefan, additional, Kondybayeva, Aida, additional, Kõrv, Janika, additional, Kravchenko, Michael, additional, Krishnamurthi, Rita V., additional, Kruja, Jera, additional, Lakkhanaloet, Mongkol, additional, Langhorne, Peter, additional, Lavados, Pablo M., additional, Law, Zhe Kang, additional, Lawal, Abisola, additional, Lazo-Porras, Maria, additional, Lebedynets, Dmytro, additional, Lee, Tsong-Hai, additional, Leung, Thomas, additional, Liebeskind, David S., additional, Lindsay, Patrice, additional, López-Jaramillo, Patricio, additional, Lotufo, Paulo Andrade, additional, Machline-Carrion, Julia, additional, Makanjuola, Akintomiwa, additional, Markus, Hugh Stephen, additional, Marquez-Romero, Juan Manuel, additional, Medina, Marco, additional, Medukhanova, Sabina, additional, Mehndiratta, Man Mohan, additional, Merkin, Alexandr, additional, Mirrakhimov, Erkin, additional, Mohl, Stephanie, additional, Moscoso-Porras, Miguel, additional, Müller-Stierlin, Annabel, additional, Murphy, Sean, additional, Musa, Kamarul Imran, additional, Nasreldein, Ahmed, additional, Nogueira, Raul Gomes, additional, Nolte, Christian, additional, Noubiap, Jean Jacques, additional, Novarro-Escudero, Nelson, additional, Ogun, Yomi, additional, Oguntoye, Richard Ayobami, additional, Oraby, Mohammed Ibrahim, additional, Osundina, Morenike, additional, Ovbiagele, Bruce, additional, Orken, Dilek Necioglu, additional, Ozdemir, Atilla Özcan, additional, Ozturk, Serefnur, additional, Paccot, Melanie, additional, Phromjai, Jurairat, additional, Piradov, Piradov, additional, Platz, Thomas, additional, Potpara, Tatjana, additional, Ranta, Annemarei, additional, Rathore, Farooq, additional, Richard, Edo, additional, Sacco, Ralph L., additional, Sahathevan, Ramesh, additional, Santos Carquín, Irving, additional, Saposnik, Gustavo, additional, Sarfo, Fred Stephen, additional, Sharma, Mike, additional, Sheth, Kevin, additional, Shobhana, A., additional, Suwanwela, Nijasri, additional, Svyato, Irina, additional, Sylaja, P.N., additional, Tao, Xuanchen, additional, Thakur, Kiran T., additional, Toni, Danilo, additional, Topcuoglu, Mehmet Akif, additional, Torales, Julio, additional, Towfighi, Amytis, additional, Truelsen, Thomas Clement, additional, Tsiskaridze, Alexander, additional, Tulloch-Reid, Marshall, additional, Useche, Nicolás, additional, Vanacker, Peter, additional, Vassilopoulou, Sophia, additional, Vukorepa, Gorana, additional, Vuletic, Vladimira, additional, Wahab, Kolawole W., additional, Wang, Wenzhi, additional, Wijeratne, Tissa, additional, Wolfe, Charles, additional, Yifru, Yared Mamushet, additional, Yock-Corrales, Adriana, additional, Yonemoto, Naohiro, additional, Yperzeele, Laetitia, additional, and Zhang, Puhong, additional

Published
2022
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48. Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis

Author

Krishnan, Kailash, Scutt, Polly, Woodhouse, Lisa, Adami, Alessandro, Becker, Jennifer L., Berge, Eivind, Cala, Lesley A., Casado, Ana M., Caso, Valeria, Chen, Christopher, Christensen, Hanna, Collins, Ronan, Czlonkowska, Anna, Dineen, Robert A., Gommans, John, Koumellis, Panos, Lees, Kennedy R., Ntaios, George, Ozturk, Serefnur, Phillips, Stephen J., Pocock, Stuart J., de Silva, Asita, Sprigg, Nikola, Szatmari, Szabolcs, Wardlaw, Joanna M., and Bath, Philip M.

Published
2016
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50. Outcomes in Antiplatelet?Associated Intracerebral Hemorrhage in the TICH?2 Randomized Controlled Trial

Author

Law, Zhe Kang, Desborough, Michael, Roberts, Ian, Al?Shahi Salman, Rustam, England, Timothy J., Werring, David J., Robinson, Thompson, Krishnan, Kailash, Dineen, Robert, Laska, Ann Charlotte, Peters, Nils, Egea?Guerrero, Juan Jose, Karlinski, Michal, Christensen, Hanne, Roffe, Christine, Bereczki, Daniel, Ozturk, Serefnur, Thanabalan, Jegan, Beridze, Maia, Bath, Philip M., and Sprigg, Nikola

Subjects
cardiovascular diseases, Cardiology and Cardiovascular Medicine
Abstract

BackgroundAntiplatelet therapy increases the risk of hematoma expansion in intracerebral hemorrhage (ICH) while the effect on functional outcome is uncertain.Methods and ResultsThis is an exploratory analysis of the TICH‐2 (Tranexamic Acid in Intracerebral Hemorrhage‐2) double‐blind, randomized, placebo‐controlled trial, which studied the efficacy of tranexamic acid in patients with spontaneous ICH within 8 hours of onset. Multivariable logistic regression and ordinal regression were performed to explore the relationship between pre‐ICH antiplatelet therapy, and 24‐hour hematoma expansion and day 90 modified Rankin Scale score, as well as the effect of tranexamic acid. Of 2325 patients, 611 (26.3%) had pre‐ICH antiplatelet therapy. They were older (mean age, 75.7 versus 66.5 years), more likely to have ischemic heart disease (25.4% versus 2.7%), ischemic stroke (36.2% versus 6.3%), intraventricular hemorrhage (40.2% versus 27.5%), and larger baseline hematoma volume (mean, 28.1 versus 22.6 mL) than the no‐antiplatelet group. Pre‐ICH antiplatelet therapy was associated with a significantly increased risk of hematoma expansion (adjusted odds ratio [OR], 1.28; 95% CI, 1.01–1.63), a shift toward unfavorable outcome in modified Rankin Scale (adjusted common OR, 1.58; 95% CI, 1.32–1.91) and a higher risk of death at day 90 (adjusted OR, 1.63; 95% CI, 1.25–2.11). Tranexamic acid reduced the risk of hematoma expansion in the overall patients with ICH (adjusted OR, 0.76; 95% CI, 0.62–0.93) and antiplatelet subgroup (adjusted OR, 0.61; 95% CI, 0.41–0.91) with no significant interaction between pre‐ICH antiplatelet therapy and tranexamic acid (P interaction=0.248).ConclusionsAntiplatelet therapy is independently associated with hematoma expansion and unfavorable functional outcome. Tranexamic acid reduced hematoma expansion regardless of prior antiplatelet therapy use.

Published
2021

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