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Ferrie, J., Shipley, M., Cappuccio, F., Brunner, E., Miller, M., Kumari, M., Marmot, M., Coenen, A., Castillo, J. L., Araya, F., Bustamante, G., Montecino, L., Torres, C., Oporto, S., Gronli, J., Fiske, E., Murison, R., Bjorvatn, B., Sorensen, E., Ursin, R., Portas, C. M., Rajaraman, S., Gribok, A., Wesensten, N., Balkin, T., Reifman, J., Dursunoglu, N., Ozkurt, S., Baser, S., Delen, O., Sarikaya, S., Sadler, P., Mitchell, P., Françon, D., Decobert, M., Herve, B., Richard, A., Griebel, G., Avenet, P., Scatton, B., Fur, G. L., Eckert, D., Jordan, A., Wellman, A., Smith, S., Malhotra, A., White, D., Bruck, D., Thomas, I., Kritikos, A., Oertel, W., Stiasny-Kolster, K., Garcia-Borreguero, D., Poewe, W., Hoegl, B., Kohnen, R., Schollmayer, E., Keffel, J., Trenkwalder, C., Valle, A., Roizenblatt, S., Fregni, F., Boggio, P., Tufik, S., Ward, K., Robertson, L., Palmer, L., Eastwood, P., Hillman, D., Lee, J., Mukherjee, S., de Padova, V., Barbato, G., Ficca, G., Zilli, I., Salzarulo, P., Veldi, M., Hion, T., Vasar, V., Kull, M., Nowak, L., Davis, J., Latzer, Y., Tzischinsky, O., Crowley, S., Carskadon, M., Anca-Herschkovitsch, M., Frey, D., Ortega, J., Wiseman, C., Farley, C., Wright, K., Campbell, A., Neill, A., Spiegel, K., Leproult, R., Tasali, E., Scherberg, N., van Cauter, E., Noradina, A. T., Karim, N. A., Norlinah, I., Raymond, A. A., Sahathevan, R., Hamidon, B., Werth, E., Poryazova, R., Khatami, R., Bassetti, C., Beran, R. G., Ainley, L., Holand, G., Duncan, J., Kinney, H., Davis, B., Hood, B., Frey, S., Schmidt, C., Hofstetter, M., Peigneux, P., Cajochen, C., Hu, W.-P., Li, J.-D., Zhang, C., Boehmer, L., Siegel, J., Zhou, Q.-Y., Sagawa, Y., Kondo, H., Takemura, T., Kanayama, H., Kaneko, Y., Sato, M., Kanbayashi, T., Hishikawa, Y., Shimizu, T., Viola, A., James, L., Schlangen, L., Dijk, D.-J., Andretic, R., Kim, Y.-C., Han, K.-A., Jones, F., Greenspan, R., Sanford, L., Yang, L., Tang, X., Dieter, K., Uta, E., Sven, H., Richard, M., Oyane, N., Pallesen, S., Holsten, F., Inoue, Y., Fujita, M., Emura, N., Kuroda, K., Uchimura, N., Johnston, A., Astbury, J., Kennedy, G., Hoedlmoser, K., Schabus, M., Pecherstorfer, T., Moser, S., Gruber, G., Anderer, P., Klimesch, W., Naidoo, N., Ferber, M., Pack, A., Neu, D., Mairesse, O., Hoffmann, G., Dris, A., Lambrecht, L., Linkowski, P., Verbanck, P., Le Bon, O., Matsuura, N., Yamao, M., Adachi, N., Aritomi, R., Komada, Y., Tanaka, H., Shirakawa, S., Kondoh, H., Takemura, F., Ohnuma, S., Suzuki, M., Uemura, S., Iskra-Golec, I., Smith, L., Thanh, D.-V., Boly, M., Phillips, C., Steven, L., Luxen, A., Maquet, M., Jay, S., Dawson, D., Lamond, N., Basner, M., Fomberstein, K., Dinges, D., Ogawa, K., Nittono, H., Yamazaki, K., Hori, T., Glamann, C., Hornung, O., Hansen, M.-L, Danker-Hopfe, H., Jung, C., Kecklund, G., Anund, A., Peters, B., Åkerstedt, T., Verster, J., Roehrs, T., Mets, M., de Senerpont Domis, L., Olivier, B., Volkerts, E., Knutson, K., Lauderdale, D., Rathouz, P., Christie, M., Chen, L., Bolortuya, Y., Lee, E., Mckenna, J., Mccarley, R., Strecker, R., Tamaki, M., Matsuoka, T., Aritake, S., Suzuki, H., Kuriyama, K., Ozaki, A., Abe, Y., Enomoto, M., Tagaya, H., Mishima, K., Matsuura, M., Uchiyama, M., Lima-Pacheco, E., Davis, K., Sabourin, C., Lortie-Lussier, M., de Koninck, J., van Der Werf, Y., van Der Helm, E., Schoonheim, M., van Someren, E., Tokley, M., Ball, M., Sato, T., Ghilardi, M. F., Moisello, C., Bove, M., Busi, M., Pelosin, E., Tononi, G., Eguchi, N., Sakata, M., Urade, Y., Doe, N., Yoshihara, K., Abe, K., Manabe, Y., Iwatsuki, K., Hayashi, T., Shoji, M., Kamiya, T., Gooley, J., Brainard, G., Rajaratnam, S., Kronauer, R., Czeisler, C., Lockley, S., Phillips, A., Robinson, P., Burgess, H., Revell, V., Eastman, C., Bihari, S., Ramakrishnan, N., Camerino, D., Conway, P. M., Costa, G., Vandewalle, G., Albouy, G., Sterpenich, V., Darsaud, A., Rauchs, G., Berken, P.-Y, Balteau, E., Maquet, P., Tendero, J. A., Domenech, M. P., Isern, F. S., Martínez, C., Roure, N., Sancho, E. E., Moreno, C. R., Silva, M., Marqueze, E. C., Waage, S., Bobko, N., Chernyuk, V., Yavorskiy, Y., Saxvig, I., Sørensen, E., de Mello, M. T., Esteves, A., Teixeira, C., Bittencourt, L. R., Silva, R., Pires, M. L., Mottram, V., Middelton, B., Arendt, J., Amaral, O., Rodrigues, M., Pereira, C., Tavares, I., Baba, K., Honma, S., Honma, K.-I., Yamanaka, Y., Hashimoto, S., Tanahashi, Y., Nishide, S.-Y, Honma, K.-I, Sletten, T., Middleton, B., Lederle, K., Skene, D., Roth, T., Walsh, J., Hogben, A., Ellis, J., Archer, S., von Schantz, M., Chen, N.-H., Wang, P.-C., Chen, C.-W., Lin, Y., Shih, T.-S., Armstrong, S., Redman, J., Stephan, E., David, M., Delanaud, S., Chardon, K., Libert, J.-P., Bach, V., Telliez, F., Reid, K., Jaksa, A., Eisengart, J., Kane, P., Naylor, E., Zee, P., Viola, A. U., de Valck, E., Hofmans, J., Theuns, P., Cluydts, R., Alexander, G., Karel, M., Christina, R., Sohn, I.-K., Cho, I. H., Kim, S. J., Yu, S.-H., Kim, H., Yoo, S. Y., Koh, S.-H., Cho, S.-J., Rotenberg, L., Silva-Costa, A., Griep, R. H., Amely, T., Kennedy, G. A., Pavlis, A., Thompson, B., Pierce, R., Howard, M., Briellmann, R., Venkateswaran, S., Blunden, S., Krawczyk, E., Blake, J., Gururajan, R., Kerr, D., Matuisi, T., Iwasaki, M., Yamasita, N., Iemura, A., Ohya, T., Yanagawa, T., Misa, R., Coleman, G., Conduit, R., Duce, B., Hukins, C., Nyandaiti, Y. W., Bamaki, S., Mohammed, A., Kwajarfa, S., Veeramachaneni, S. P., Murthy, A., Wilson, A., Maul, J., Hall, G., Stick, S., Moseley, L., Gradisar, M., Kurihara, T., Yamamoto, M., Yamamoto, S., Kuranari, M., Sparks, C. B., Bartle, A., Beckert, L., Latham-Smith, F. B., Hilton, J., Whitehead, B., Gulliver, T., Salvini, A., Grahame, S., Swift, M., Laybutt, N., Sharon, D., Mack, C., Hymell, B., Perrine, B., Ideshita, K., Taira, M., Matuo, A., Furutani, M., van Dongen, H., Mott, C., Huang, J.-K., Mollicone, D. J., Mckenzie, F., Dinges, David, Barnes, M., Rochford, P., Churchward, T., O’Donoghue, F., Penzel, T., Fietze, I., Canisius, S., Bekiaris, E., Terrill, P. I., Wilson, S., Suresh, S., Cooper, D., Suzuki, T., Ouchi, K., Moriya, A., Kameyama, K., Takahashi, M., Büttner, A., Rühle, K.-H., Wang, D., Wong, K., Dungan, II, G., Grunstein, R., Davidson, P., Jones, R., Gergely, V., Mashima, K., Miyazaki, S., Tanaka, T., Okawa, M., Yamada, N., Wyner, A., Raizen, D., Galante, R., Ng, A. K., Koh, T. S., Lim, L. L., Puvanendran, K., Peiris, M., Bones, P., Roebuck, T., Ho, S., Szollosi, I., Naughton, M., Williams, G., Parsley, C., Harris, M.-A., Thornton, A., Ruehland, W., Banks, S., Arroyo, S., Carroll, K., Pilmore, J., Stewart, C., Hamilton, G., van Acker, F., Cvetkovic, D., Holland, G., Cosic, I., Tolson, J., Worsnop, C., Cresswell, P., Hart, I., Bouarab, M., Delechelle, E., Drouot, X., Acebo, C., Singh, P., Lakey, T., Schachter, L., Rand, J., Collin, H., Snyder, E., Ma, J., Svetnick, V., Deacon, S., Dana, B., Konstanze, D., Uwe, M., Ingo, F., Thomas, P., Ivar, R., Mackiewicz, M., Shockley, K., Romer, M., Zimmerman, J., Baldwin, D., Jensen, S., Churchill, G., Paigen, B., Imeri, L., Ferrari, L., Bianchi, S., Dossena, S., Garofoli, A., Mangieri, M., Tagliavini, F., Forloni, G., Chiesa, R., Pedrazzoli, M., Pereira, D., Veauny, M., Bodenmann, S., Hohoff, C., Freitag, C., Deckert, J., Rétey, J., Landolt, H.-P., Strohl, K., Price, E., Yamauchi, M., Dostal, J., Feng, P., Han, F., Havekes, R., Novati, A., Hagewoud, R., Barf, P., van Der Borght, K., van Der Zee, E., Meerlo, P., Ruby, P., Caclin, A., Boulet, S., Delpuech, C., Morlet, D., Veasey, S., Aton, S., Jha, S., Coleman, T., Seibt, J., Frank, M., Lack, L., Churches, O., Feng, S. Y. S., Cassaglia, P., Yu, V. Y. H., Walker, A. M., Kohler, M., Kennedy, D., Martin, J., van Den Heuvel, C., Lushington, K., Herron, K., Khurana, C., Sterr, A., Olivadoti, M., Toth, L., Opp, M., Dang-Vu, T., Degueldre, C., Gais, S., Dang-Vu, T. T., Desseilles, M., Philips, C., Chijavadze, E., Babilodze, M., Chkhartishvili, E., Nachkebia, N., Mchedlidze, O., Dzadzamia, S., Griffiths, R., Walker, A., Horovitz, S., Fukunaga, M., Carr, W., Picchioni, D., de Zwart, J., van Gelderen, P., Braun, A., Duyn, J., Hanlon, E. H., Faraguna, U., Vyazovskiy, V., Cirelli, C., Ocampo-Garcés, A., Ibáñez, F., López, S., Vivaldi, E., Torrealba, F., Romanowski, C. P. N., Fenzl, T., Flachskamm, C., Deussing, J., Kimura, M., Tarokh, L., van Reen, E., Dorn, H., Velluti, R., Qu, W.-M., Huang, Z.-L., Hayaishi, O., Pedemonte, M., Drexler, D., Pol-Fernández, D., Bernhardt, V., Lopez, C., Rodriguez-Servetti, Z., Romanowski, C., Polta, S., Yassouridis, A., Abe, T., Takahashi, K., Koyama, Y., Kayama, Y., Lin, J.-S., Sakai, K., Gulia, K., Karashima, A., Shimazaki, M., Katayama, N., Nakao, M., Winsky-Sommerer, R., Knapman, A., Tobler, I., Altena, E., Sanz-Arigita, E., Chang, F.-C., Lu, C.-Y., Yi, P.-L., Hsiao, Y.-Z., Lowden, A., Nilsson, J., Hillert, L., Wiholm, C., Kuster, N., Arnetz, B., Szameitat, A., Shen, S., Daurat, A., Tiberge, M., Sok, N., D’Ortho, M. P. I. A., Karasinsky, P., Kohlmeier, K., Wess, J., Leonard, C., Kristensen, M., Kalinchuk, A., Porkka-Heiskanen, T., Mccarley, R. W., Basheer, R., Aizawa, R., Sunahara, H., Abe, S.-I., Iwaki, S., Houjyou, M., Satoh, M., Suda, H., Kheirandish-Gozal, L., Gozal, D., Walker, P., Noa, A., O’Driscoll, D., Ng, M., Yang, J., Davey, M., Anderson, V., Trinder, J., Horne, R., Sands, S., Kelly, V., Sia, K., Edwards, B., Skuza, E., Davidson, M., Berger, P. H. I. L. I. P., Wilkinson, M., Sánchez-Narváez, F., Gutiérrez, R., Camacho, L., Anaya, E., García-Campos, E., Labra, A., Domínguez, G., García-Polo, L., Haro, R., Verginis, N., Nixon, G., Baumert, M., Pamula, Y., Mihai, R., Wawurszak, M., Smith, N., Yiallourou, S., Andrew Ramsden, C., Williamson, B., Blecher, G., Teng, A., Dakin, C. Y. N., Yuil, M., Harris, M., Sadasivam, S., Bennison, J., Galland, B., Dawes, P., Taylor, B., Norman, M., Edwards, N., Harrison, H., Kol, C., Sullivan, C., Valladares, E., Macey, P., Kumar, R., Woo, M., Harper, R., Alger, J., Mcnamara, D., Tang, J., Goh, A., Teoh, O. H., Chiang, W. C., Chay, O. M., Marie Salvini, A., Riben, C., Blanck, A.-S., Marklund, M., Tourneux, P., Cardot, V., Leke, A., Iqbal, S. M., (Gus) Cooper, D., Witmans, M., Rodger, K., Thevasagayam, R., El-Hakim, H., Hill, C. M., Baya, A., Bucks, R., Kirkham, F., Virues-Ortega, J., Baldeweg, T., Paul, A., Hogan, A., Goodwin, J., Silva, G., Kaemingk, K., Sherrill, D., Morgan, W., Fregosi, R., Quan, S., Evans, C., Maclean, J., Waters, K., Fitzsimmons, D., Hayward, P., Fitzgerald, D., Terrill, G., O’Connell, A., Vannan, K., Richardson, H., Poluektov, M., Levin, I., Snegodskaya, M., Kolosova, N., Geppe, N., Nixon, G. Michelle, Thompson, J., Yhan, D., Becroft, D., Clark, P., Robinson, E., Waldie, K., Wild, C., Black, P., Stone, K., Britton, W., Chaves, Claudia, Tinoco, C., Goncalves, C., Ferreira, E., Santos, H., Boloto, J., Duarte, L., Paine, S., Wright, H., Slater, A., Rosen, G., Telliez, Frédéric, Djeddi, D., Kongolo, G., Degrugilliers, L., Horton, J., Buscemi, N., Vandermeer, B., Owens, J., Klassen, T., Gordon, J., King, N., Tripp, G., Oka, Y., Suzuki, S., de Lemos, M. C., Gonzaga, F. G., Shah, M. L., Bittencourt, L., Oliveira, L. V. Franco, Elshoff, J.-P., Braun, M., Andreas, J.-O., Strauss, B., Horstmann, R., Ahrweiler, S., Goldammer, N., Wada, M., Matsumoto, N., Rahman, M. D., Xu, X.-H., Makino, Y., Hashimoto, K., Zhang, M., Sastre, J.-P., Buda, C., Anaclet, C., Ohtsu, H., Danober, L., Desos, P., Cordi, A., Roger, A., Jacquet, A., Rogez, N., Thomas, J.-Y., Krentner, M., Boutin, J., Audinot-Bouchez, V., Baumann, C., Valko, P., Uhl, M., Hersberger, M., Rupp, T., Uchiyama, N., Nakamura, N., Konishi, T., Mcgrath, P., Fujiki, N., Tokunaga, J., Iijima, S., Nishino, S., Catherine, B.-R., Lely, F., Ralf, K., Oliver, N., François, J., Francois, J., Cedric, F., Changbin, Q., Patrick, H., Homanics, G., Heussler, H., Norris, R., Pache, D., Charles, B., Mcguire, T., Shelton, J., Bonaventure, P., Kelly, L., Aluisio, L., Lovenberg, T., Atack, J., Dugovic, C., Shapiro, C., Shen, J., Trajanovic, N., Chien, J., Verma, M., Fish, V., Wheatley, J., Amis, T., Alexiou, T., Wild, J., Bjursell, A., Solin, P., Sato, S., Matsubuchi, N., Gingras, M.-A., Labrosse, M., Chevrier, É, Lageix, P., Guay, M.-C., Braun, C., Godbout, R., Fatim, E. H., Loic, D., Stephane, D., Nathalie, L., Stéphane, D., Alain, G., Wiâm, R., Koabyashi, T., Tomita, S., Ishikawa, T., Manadai, O., Arakawa, K., Siato, Y., Bassi, A., Ocampo, A., Estrada, J., Blyton, D., O’Keeffe, K., Galletly, D., Larsen, P., Amatoury, J., Bilston, L., Kairaitis, K., Stephenson, R., Chu, K., Sekiguchi, Y., Suzuki, N., Yasuda, Y., Kodama, T., Honda, Y., Hsieh, K.-C., Lai, Y.-Y., Bannai, M., Kawai, N., Amici, R., Baracchi, F., Cerri, M., Del Sindaco, E., Dentico, D., Jones, C. A., Luppi, M., Martelli, D., Perez, E., Tazaki, M., Katayose, Y., Yasuda, K., Tokuyama, K., Maddison, K., Platt, P., Kirkness, J., Ware, J. C., May, J., Rosenthal, T., Park, G., Guibert, M., Allen, R. W., Cetin, T., Roman, V., Mollicone, D., Crummy, F., Cameron, P., Swann, P., Kossman, T., Taggart, F., Kandala, N.-B., Currie, A., Peile, E., Stranges, S., Marshall, N., Peltonen, M., Stenlof, K., Hedner, J., Sjostrom, L., Anderson, C., Platten, C., Jordan, K., Horne, J., Bjorkum, A., Kluge, B., Braseth, T., Gurvin, I., Kristensen, T., Nybo, R., Rosendahl, K., Nygaard, I., Biggs, S., Dollman, J., Kennedy, J. D., Martin, A. J., Haghighi, K. S., Bakht, N., Hyde, M., Harris, E., Zerouali, Y., Hosein, A., Jemel, B., Dodd, M., Rogers, N., Andersen, M., Martins, R., Alvarenga, T., Antunes, I., Papale, L., Killgore, W. S., Axelsson, J., Lekander, M., Ingre, M., Brismar, K., Dorrian, J., Ferguson, S., Jones, C., Buxton, O., Marcelli, E., Phipps-Nelson, J. O., Teixeira, L. R., de Castro Moreno, C., Turte, S. L., Nagai, R., do Rosário Dias De Oliveira Latorre, M., Marina, F., Paterson, J., Jackson, M., Johnston, P., Papafotiou, K., Croft, R., Dawson, S., Leenaars, C., Sandberg, H., Joosten, R., Dematteis, M., Feenstra, M., Wehrle, R., Rieger, M., Widmann, A., Dietl, T., Philipp, S., Wetter, T., Drummond, S., Czisch, M., Cairns, A., Lebourgeois, M., Harsh, J., Baulk, S., Vakulin, A., Catcheside, P., Antic, N., Mcevoy, D., Orff, H., Salamat, J., Meloy, M. J., Caron, A., Kostela, J., Purnell, M., Feyer, A.-M., Herbison, P., Saaresranta, T., Aittokallio, J., Karppinen, N., Toikka, J., Polo, O., Sallinen, M., Haavisto, M.-L., Hublin, C., Kiti, M., Jussi, V., Mikko, H., Chuah, L., Chee, M., Borges, F., Fischer, F., Moreno, C., Soares, N., Fonseca, M., Smolensky, M., Sackett-Lundeen, L., Haus, E., Nagata, N., Michael, N., Siccoli, M., Rogers, A., Hwang, W.-T., Scott, L., Dean, G., Geissler, E., Ametamey, S., Treyer, V., Wyss, M., Achermann, P., Schubiger, P., Theorell-Haglöw, J., Berne, C., Janson, C., Svensson, M., Lindberg, E., Caruso, H., Avinash, D., Minkel, J., Thompson, C., Wisor, J., Gerashchenko, D., Smith, K., Kuan, L., Pathak, S., Hawrylycz, M., Jones, A., Kilduff, T., Bergamo, C., Ecker, A., William, J., Niyogi, S., Coble, M., Goel, N., Lakhtman, L., Horswill, M., Whetton, M., Chambers, B., Signal, L., van Den Berg, M., Gander, P., Polotsky, V., Savransky, V., Bevans, S., Nanayakkara, A., Li, J.-G., Smith, P., Torbenson, M., Stockx, E., Brodecky, V., Berger, P., Chung-Mei Lam, J., Rial, R., Roca, C., Garau, C., Akaarir, M., Mccoy, J., Ward, C., Connolly, N., Tartar, J., Brown, R., Carberry, J., Bradford, A., O’Halloran, K., Mcguire, M., Nacher, M., Serrano-Mollar, A., Navajas, D., Farre, R., Montserrat, J., Fenik, V., Rukhadze, I., Kubin, L., Sivertsen, B., Overland, S., Mykletun, A., Czira, M., Fornádi, K., Lindner, A., Szeifert, L., Szentkirályi, A., Mucsi, I., Molnár, M., Novák, M., Zoller, R., Chin, K., Takegami, M., Oga, T., Nakayama-Asida, Y., Wakamura, T., Mishima, M., Fukuhara, S., Shepherd, K., Keir, G., Rixon, K., Makarie-Rofail, L., Unger, G., Svanborg, E., Harder, L., Sarberg, M., Broström, A., Josefsson, A., Herrera, A., Aguilera, L., Diaz, M., Fedson, A., Hung, J., Williams, C., Love, G., Middleton, S., Vermeulen, W., Middleton, P., Steinfort, D., Goldin, J., Eritaia, J., Dionysopoulos, P., Irving, L., Ciftci, T. U., Kokturk, O., Demirtas, S., Kanbay, A., Tavil, Y., Bukan, N., Demritas, S., Olsen, S., Douglas, J., Oei, T., Williams, S., Leung, S., Starmer, G., Lee, R., Chan, A., Dungan, G., Cistulli, P., Zeng, B., Bansal, A., Patial, K., Vijayan, V. K., Sonka, K., Fialova, L., Svarcova, J., Volna, J., Jiroutek, P., Pretl, M., Bartos, A., Hasegawa, R. A., Sasanabe, R., Nomura, A., Morita, M., Hori, R., Ohkura, Y., Shiomi, T. T., Collins, A., Jerums, G., Hare, D., Panagiotopoulos, S., Weatherhead, B., Bailey, M., Neil, C., Goldsworthy, U., Hill, C., Valencia-Flores, M., Resendiz, M., Juarez, S., Castano, A., Santiago, V., Aguilar, C., Ostrosky, F., Krum, H., Kaye, D., Neves, C., Decio, M., Monteiro, M., Cintra, F., Poyares, D., Viegas, C., Silva, C., Oliveira, H., Peixoto, T., Mikami, A., Watanabe, T., Kumano-Go, T., Adachi, H., Sugita, Y., Takeda, M., Oktay, B., Firat, H., Akbal, E., Ardic, S., Paim, S., Santos, R., Barrreto, A., Whitmore, H., Imperial, J., Temple, K., Rue, A., Hoffman, L., Liljenquist, D., Kazsa, K., Pavasovic, M., Copland, J., Ho, M., Jayamaha, J., Peverill, R., Hii, S., Hensley, M., Rowland, S., Windler, S., Johansson, M., Eriksson, P., Peker, Y., Råstam, L., Lindblad, U., Grote, L., Zou, D., Radlinski, J., Eder, D., Plens, C. M., Garcia Gonzaga, F. M., Farias Sa, P., Franco Oliveira, L. V., Faria Sa, P., Yoon, I.-Y., Chung, S., Hee Lee, C., Kim, J.-W., Faludi, B., Wang, X., Li, Q., Wan, H., Li, M., Pallayova, M., Donic, V., Tomori, Z., Ioacara, S., Olech, T., Mccallum, C., Bowes, M., Bowes, J., Chia, M., Gilbert, S. S., Sajkov, D., Teichtahl, H., Stevenson, I., Cunnington, D., Kalman, J., Szaboova, E., Higami, S., Kryger, M., Higami, Y., Suzuki, C., Kitano, H., Carin, S., Olof, S., Yngve, G., Gösta, B., Carlberg, B., Stenlund, H., Franklin, K. A., Oliveira, A., Vasconcelos, L., Martinez, D., Goncalves, S. C., Gus, M., Silva, E. O. A., Fuchs, S. C., Fuchs, F. 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H., Arand, D., Bonnet, J., Bonnet, M., Doi, Y., Edéll-Gustafsson, U., Strijers, R., Fernando, A., Arroll, B., Warman, G., Funakura, M., Shikano, S., Unemoto, Y., Fujisawa, M., Hong, S.-C., Jeong, J.-H., Shin, Y.-K., Han, J.-H., Lee, S.-P., Lee, J.-H., Mignot, E., Nakajima, T., Hayashida, K., Honda, M., Ardestani, P., Etemadifar, M., Nejadnik, H., Maghzi, A. H., Basiri, K., Ebrahimi, A., Davoodi, M., Peraita-Adrados, R., Vicario, J. L., Shin, H.-B., Marti, I., Carriero, L., Fulda, S., Beitinger, P., Pollmacher, T., Lam, J. S. P., Fong, S. Y. Y., Tang, N. L. S., Ho, C. K. W., Li, A. M. C., Wing, Y. K., Guilleminault, C., Black, J., Wells, C., Kantor, S., Janisiewicz, A., Scammell, T., Tanaka, S., Smith, A., Neufing, P., Gordon, T., Fuller, P., Gompf, H., Pedersen, N., Saper, C., Lu, J., Sasai, T., Donjacour, C., Fronczek, R., Le Cessie, S., Lammers, G. J., van Dijk, J. G., Hayashi-Ogawa, Y., Okuda, M., Lam, V. K.-H., Chen, A. L., Ho, C. K.-W., Wing, Y.-K., Lehrhaft, B., Brilliante, R., van Der Zande, W., Overeem, S., van Dijk, G., Lammers, J. G., Opazo, C. J., Jeong, D.-U., Sung, Y. H., Lyoo, I. K., Takahashi, Y., Murasaki, M., Bloch, K., Jung, H., Dahab, M. M., Campos, T. F., Mccabe, S., Maravic, K., Wiggs, L., Connelly, V., Barnes, J., Saito, Y., Ogawa, M., Murata, M., Nadig, U., Rahman, A., Aritake, K., D’Cruz, O., Suzuki, K., Kaji, Y., Takekawa, H., Nomura, T., Yasui, K., Nakashima, K., Bahammam, A., Rab, M. G., Owais, S., Alsuwat, K., Hamam, K., Zs, M., Boroojerdi, B., Giladi, N., Wood, D., Sherman, D., Chaudhuri, R., Partinen, M., Abdo, F., Bloem, B., Kremer, B., Verbeek, M., Cronlein, T., Mueller, U., Hajak, G., Zulley, J., Namba, K., Li, L., Mtsuura, M., Kaneita, Y., Ohida, T., Cappeliez, B., Moutrier, R., De, S., Dwivedi, S., Chambers, D., Gabbay, E., Watanabe, A., Valle, C., Kauati, A., Watanabe, R., Chediek, F., Botte, S., Azevedo, E., Kempf, J., Cizza, G., Torvik, S., Brancati, G., Smirne, N., Bruni, A., Goff, E., Freilich, S., Malaweera, A., Simonds, A., Mathias, C., Morrell, M., Rinsky, B., Fonarow, G., Gradinger, F. P., Boldt, C., Geyh, S., Stucki, A., Dahlberg, A., Michel, F., Savard, M.-H., Savard, J., Quesnel, C., Hirose, K., Takahara, M., Mizuno, K., Sadachi, H., Nagashima, Y., Yada, Y., Cheung, C.-F., Lau, C., Lai, W., Sin, K., Tam, C., Hellgren, J., Omenaas, E., Gíslason, T., Jögi, R., Franklin, K., Torén, K., Wang, F., Kadono, M., Shigeta, M., Nakazawa, A., Ueda, M., Fukui, M., Hasegawa, G., Yoshikawa, T., de Niet, G., Tiemens, B., Lendemeijer, B., Hutschemaekers, G., Gauthier, A.-K., Chevrette, T., Chevrier, E., Bouvier, H., Parry, B., Meliska, C., Nowakowski, S., Lopez, A., Martinez, F., Sorenson, D., Lien, M. L., Lattova, Z., Maurovich-Horvat, E., Nia, S., Pollmächer, T., Poulin, J., Chouinard, S., Stip, E., Guillem, F., Venne, D., Caouette, M., Lamont, M.-E., Lázár, A., Lázár, Z., Bíró, A., Gyõri, M., Tárnok, Z., Prekop, C., Gádoros, J., Halász, P., Bódizs, R., Okun, M., Hanusa, B., Hall, M., Wisner, K., Pereira, M., Kumar, R. A. J. E. S. H., Macey, P. A. U. L., Woo, M. A. R. Y., Serber, S. T. A. C. Y., Valladares, E. D. W. I. N., Harper, R. E. B. E. C. C. A., Harper, R. O. N. A. L. D., Puttonen, S., Härmä, M., Vahtera, J., Kivimäki, M., Lamarche, L., Hemmeter, U. M., Thum, A., Rocamora, R., Giesler, M., Haag, A., Dodel, R., Krieg, J. C., Shechter, A., L’Esperance, P., Boivin, D. B., Vu, M.-T., and Richards, H.

Published
2007
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6. Immunization status in chronic obstructive pulmonary disease: A multicenter study from Turkey

Author

Ozlu, Tevfik, Bulbul, Yilmaz, Aydin, Derya, Tatar, Dursun, Kuyucu, Tulin, Erboy, Fatma, Koseoglu, Handan Inonu, Anar, Ceyda, Sunnetcioglu, Aysel, Gulhan, Pinar Yildiz, Sahin, Unal, Ekici, Aydanur, Duru, Serap, Ulasli, Sevinc Sarinc, Kurtipek, Ercan, Gunay, Sibel, Okutan, O., Yildiz, B. P., Cetinkaya, P. D., Arslan, S., Cakmak, G., Cirak, A. K., Sarioglu, N., Kocak, N. D., Akturk, U. A., Demir, M., Kilic, T., Dalli, A., Hezer, H., Altintas, N., Acat, M., Dagli, C. E., Kargi, A., Yakar, F., Kirkil, G., Baccioglu, A., Gedik, C., Intepe, Y. S., Karadeniz, G., Onyilmaz, T., Saylan, B., Baslilar, S., Sariman, N., Ozkurt, S., Arinc, S., Kanbay, A., Yazar, E. E., Yildirim, Z., Kadioglu, E. E., Gul, S., Sengul, A., Berk, S., Dikis, O. S., Kurt, O. K., Arslan, Y., Erol, S., Korkmaz, C., Balaban, A., Erbay, Toru U., Sogukpinar, O., Uzaslan, E. K., Babaoglu, E., Bahadir, A., Baris, S. A., Ugurlu, A. O., Ilgazli, A. H., Fidan, F., Kararmaz, E., Guzel, A., Alzafer, S., Cortuk, M., Hocanli, I., Ortakoylu, M. G., Erginel, M. S., Yaman, N., Erbaycu, A. E., Demir, A., Duman, D., Tanriverdi, H., Yavuz, M. Y., Sertogullarindan, B., Ozyurt, S., Bulcun, E., Yuce, G. D., Sariaydin, M., Ayten, O., Bayraktaroglu, M., Tekgul, S., Erel, F., Senyigit, A., Kaya, S. B., Ayik, S., Yazici, O., Akgedik, A., Yasar, Z. A., Hayat, E., Kalpaklioglu, F., Sever, F., Sarac, P., Ugurlu, E., Kasapoglu, U. S., Gunluoglu, G., Demirci, N. Y., Bora, M., Talay, F., Ozkara, B., Yilmaz, M. U., Yavsan, D. M., Cetinoglu, E. D., Balcan, M. B., Ciftci, T., Havan, A., Gok, A., Nizam, M., Investigators, R.I.M.P.A.C.T. Study, Acibadem University Dspace, Maltepe Üniversitesi, BAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Talay, Fahrettin, OMÜ, Tıp Fakültesi, Kırıkkale Üniversitesi, Zonguldak Bülent Ecevit Üniversitesi, [Ozlu, Tevfik -- Bulbul, Yilmaz] Karadeniz Tech Univ, Sch Med, Dept Chest Dis, TR-61080 Trabzon, Turkey -- [Aydin, Derya] Pulm Dis Hosp, Chest Dis Clin, Balikesir, Turkey -- [Tatar, Dursun -- Anar, Ceyda] Dr Suat Seren Pulm Dis & Thorac Surg Educ & Res H, Dept Pulm Dis, Izmir, Turkey -- [Kuyucu, Tulin] Sureyyapasa Pulm Dis & Thorac Surg Educ & Res Hos, Dept Pulm Dis, Istanbul, Turkey -- [Erboy, Fatma] Bulent Ecevit Univ, Sch Med, Dept Chest Dis, Zonguldak, Turkey -- [Koseoglu, Handan Inonu] Gaziosmanpasa Univ, Sch Med, Dept Chest Dis, Tokat, Turkey -- [Sunnetcioglu, Aysel] Yuzuncu Yil Univ, Sch Med, Dept Chest Dis, Van, Turkey -- [Gulhan, Pinar Yildiz] Tosya State Hosp, Chest Dis Clin, Kastamonu, Turkey -- [Sahin, Unal] Recep Tayyip Erdogan Univ, Sch Med, Dept Chest Dis, Rize, Turkey -- [Ekici, Aydanur] Kirikkale Univ, Sch Med, Dept Chest Dis, Kirikkale, Turkey -- [Duru, Serap] Diskapi Yildirim Beyazid Educ & Res Hosp, Dept Pulm Dis, Ankara, Turkey -- [Ulasli, Sevinc Sarinc] Hacettepe Univ, Sch Med, Dept Chest Dis, Ankara, Turkey -- [Kurtipek, Ercan] Konya Educ & Res Hosp, Dept Pulm Dis, Konya, Turkey -- [Gunay, Sibel] Afyon State Hosp, Chest Dis Clin, Afyon, Turkey -- [Okutan, O. -- Ayten, O.] Haydarpasa Hosp, Gulhane Mil Med Acad, Dept Chest Dis, Istanbul, Turkey -- [Yildiz, B. P. -- Yazar, E. E. -- Gul, S. -- Bahadir, A. -- Ortakoylu, M. G. -- Bayraktaroglu, M. -- Gunluoglu, G. -- Nizam, M.] Pulm Dis & Thorac Surg Educ & Res Hosp Yedikule, Istanbul, Turkey -- [Cirak, A. K. -- Karadeniz, G. -- Erol, S. -- Erbaycu, A. E. -- Demir, A. -- Yavuz, M. Y. -- Tekgul, S. -- Sever, F. -- Yilmaz, M. U.] Dr Suat Seren, Izmir, Turkey -- [Kocak, N. D. -- Akturk, U. A. -- Arinc, S. -- Sogukpinar, O. -- Duman, D. -- Kasapoglu, U. S.] Sureyyapasa, Istanbul, Turkey -- [Cetinkaya, P. D.] Educ & Res Hosp Numune, Adana, Turkey -- [Dikis, O. S. -- Bora, M.] Sevket Yilmaz, Bursa, Turkey -- [Balaban, A.] Evliya Celebi, Kutahya, Turkey -- [Yuce, G. D.] Diskapi Yildirim Beyazid, Ankara, Turkey -- [Arslan, S. -- Berk, S.] Cumhuriyet Univ, Sch Med, Dept Chest Dis, Sivas, Turkey -- [Sarioglu, N. -- Erel, F.] Balikesir Univ, Balikesir, Turkey -- [Demir, M. -- Senyigit, A.] Dicle Univ, Diyarbakir, Turkey -- [Kilic, T. -- Kaya, S. B.] Inonu Univ, Malatya, Turkey -- [Dalli, A. -- Ayik, S.] Katip Celebi Univ, Izmir, Turkey -- [Altintas, N.] Namik Kemal Univ, Tekirdag, Turkey -- [Acat, M. -- Cortuk, M. -- Yazici, O.] Karabuk Univ, Karabuk, Turkey -- [Dagli, C. E. -- Akgedik, A.] Ordu Univ, Ordu, Turkey -- [Kargi, A. -- Kurt, O. K. -- Yasar, Z. A. -- Talay, F.] Abant Izzet Baysal Univ, Bolu, Turkey -- [Yakar, F. -- Hayat, E.] Bezmialem Vakif Univ, Istanbul, Turkey -- [Kirkil, G.] Firat Univ, Elazig, Turkey -- [Baccioglu, A. -- Bulcun, E. -- Kalpaklioglu, F.] Kirikkale Univ, Kirikkale, Turkey -- [Gedik, C. -- Kanbay, A.] Medeniyet Univ, Istanbul, Turkey -- [Intepe, Y. S.] Bozok Univ, Yozgat, Turkey -- [Sariman, N.] Maltepe Univ, Istanbul, Turkey -- [Ozkurt, S. -- Ugurlu, E.] Pamukkale Univ, Denizli, Turkey -- [Yildirim, Z. -- Demirci, N. Y.] Gazi Univ, Ankara, Turkey -- [Korkmaz, C. -- Yavsan, D. M.] Necmettin Erbakan Univ, Konya, Turkey -- [Erbay, Toru U.] Dumlupinar Univ, Kutahya, Turkey -- [Uzaslan, E. K. -- Cetinoglu, E. D.] Uludag Univ, Bursa, Turkey -- [Baris, S. A. -- Ilgazli, A. H. -- Ciftci, T.] Kocaeli Univ, Kocaeli, Turkey -- [Fidan, F. -- Havan, A.] Fatih Univ, Istanbul, Turkey -- [Guzel, A. -- Gok, A.] Ondokuz Mayis Univ, Samsun, Turkey -- [Alzafer, S.] Acibadem Univ, Bakirkoy Hosp, Istanbul, Turkey -- [Erginel, M. S.] Osmangazi Univ, Eskisehir, Turkey -- [Tanriverdi, H.] Bulent Ecevit Univ, Zonguldak, Turkey -- [Sertogullarindan, B.] Yuzuncu Yil Univ, Van, Turkey -- [Ozyurt, S.] Recep Tayyip Erdogan Univ, Rize, Turkey -- [Sariaydin, M.] Afyon Kocatepe Univ, Afyon, Turkey -- [Onyilmaz, T. -- Sarac, P.] State Hosp Mardin, Mardin, Turkey -- [Arslan, Y. -- Ozkara, B.] Etimesgut Mil Hosp, Ankara, Turkey -- [Ugurlu, A. O. -- Balcan, M. B.] Baskent Univ, Istanbul Hosp, Istanbul, Turkey -- [Yaman, N.] Pulm Dis Hosp, Balikesir, Turkey, intepe, yavuz selim -- 0000-0002-5697-5291, Sertogullarindan, Bunyamin -- 0000-0002-1478-1990, and Bulbul, Yilmaz -- 0000-0002-8488-3650

Subjects
Acute Exacerbations, Pulmonary and Respiratory Medicine, lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, Coverage, pneumococcal vaccine, Exacerbation, disease exacerbation, influenza vaccine, Influenza vaccine, Copd Exacerbation, Self-Reported Influenza, Chronic Obstructive Pulmonary Disease Exacerbation, Latin-American Cities, Logistic regression, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Prevalence, medicine, chronic obstructive pulmonary disease exacerbation, Adults, Mass index, 030212 general & internal medicine, Determinants, lcsh:RC705-779, COPD, business.industry, Chronic obstructive pulmonary disease, chronic obstructive pulmonary, Retrospective cohort study, lcsh:Diseases of the respiratory system, Frequency, medicine.disease, Vaccination, 030228 respiratory system, Pneumococcal vaccine, lcsh:RC666-701, Pneumococcal Vaccination, Original Article, Surgery, Cardiology and Cardiovascular Medicine, business
Abstract

WOS: 000455908800007, PubMed ID: 30745939, OBJECTIVE: The purpose of this study is to detect the prevalence and the factors associated with influenza and pneumococcal vaccination and outcomes of vaccination during 2013-2014 season in patients with chronic obstructive pulmonary disease (COPD) in Turkey. METHODS: This was a multicenter retrospective cohort study performed in 53 different centers in Turkey. RESULTS: During the study period, 4968 patients were included. COPD was staged as GOLD 1-2-3-4 in 9.0%, 42.8%, 35.0%, and 13.2% of the patients, respectively. Influenza vaccination rate in the previous year was 37.9%; and pneumococcus vaccination rate, at least once during in a life time, was 13.3%. Patients with older age, higher level of education, more severe COPD, and comorbidities, ex-smokers, and patients residing in urban areas had higher rates of influenza vaccination. Multivariate logistic regression analysis showed that advanced age, higher education levels, presence of comorbidities, higher COPD stages, and exacerbation rates were associated with both influenza and pneumococcal vaccination. The number of annual physician/outpatient visits and hospitalizations due to COPD exacerbation was 2.73 +/- 2.85 and 0.92 +/- 1.58 per year, respectively. Patients with older age, lower education levels, more severe COPD, comorbid diseases, and lower body mass index and patients who are male and are residing in rural areas and vaccinated for influenza had significantly higher rates of COPD exacerbation. CONCLUSIONS: The rates of influenza and pneumococcal vaccination in COPD patients were quite low, and the number of annual physician/outpatient visits and hospitalizations due to COPD exacerbation was high in Turkey. Advanced age, higher education levels, comorbidities, and higher COPD stages were associated with both influenza and pneumococcal vaccination.

Published
2019

7. with healthy controls

Author

Turk, AC, Fidan, N, Ozcan, O, Ozkurt, S, Musmul, A, and Sahin, F

Subjects
musculoskeletal diseases, hemodialysis, shoulder, magnetic resonance imaging, urologic and male genital diseases, human activities, eye diseases, Amyloidosis, beta(2) microglobulin, chronic kidney disease
Abstract

BACKGROUND: Shoulder involvement is frequently observed in chronic renal disease (CRD) and hemodialysis patients.

Published
2020

10. Determination of anthropometric measurements in obstructive sleep apnea

Author

Ursavas, A, Ozturk, O, Kokturk, O, Mutlu, P, Kilic, H, Guzel, A, Aydin Guclu, O, Erboy, F, Arguder, E, Hezer, H, Seref Parlak, ES, Pazarli, AC, Ozkurt, S, Dursunoglu, N, Sevimli, H, Kanbay, A, Tutar, U, Yesilkaya, S, Arslan, NG, Savas Bozbas, S, Kupeli, E, Pinar, M, Ermis, H, Ozdilekcan, C, Sarioglu, N, Cetintas Avsar, G, Usalan, AK, Sarac, S, Ekici, A, and Burgazlioglu, B

Subjects
fluids and secretions, OSAS, gender, neck circumference, waist circumference, waist/hip ratio, complex mixtures
Abstract

Introduction: In this study, we aimed to determine the values of anthropometric measurements and rates used in the evaluation of obstructive sleep apnea syndrome (OSAS) in our country. Materials and Methods: Twenty accredited sleep centers in thirteen provinces participated in this multicenter prospective study. OSAS symptoms and polysomnographic examination and apnea-hypopnea index (AHI) >= 5 cases OSAS study group; patients with AHI

Published
2019

11. multicenter study from Turkey

Author

Ozlu, T, Bulbul, Y, Aydin, D, Tatar, D, Kuyucu, T, Erboy, F, Koseoglu, HI, Anar, C, Sunnetcioglu, A, Gulhan, PY, Sahin, U, Ekici, A, Duru, S, Ulasli, SS, Kurtipek, E, Gunay, S, Okutan, O, Yildiz, BP, Cetinkaya, PD, Arslan, S, Cakmak, G, Cirak, AK, Sarioglu, N, Kocak, ND, Akturk, UA, Demir, M, Kilic, T, Dalli, A, Hezer, H, Altintas, N, Acat, M, Dagli, CE, Kargi, A, Yakar, F, Kirkil, G, Baccioglu, A, Gedik, C, Intepe, YS, Karadeniz, G, Onyilmaz, T, Saylan, B, Baslilar, S, Sariman, N, Ozkurt, S, Arinc, S, Kanbay, A, Yazar, EE, Yildirim, Z, Kadioglu, EE, Gul, S, Sengul, A, Berk, S, Dikis, OS, Kurt, OK, Arslan, Y, Erol, S, Korkmaz, C, Balaban, A, Erbay, UT, Sogukpinar, O, Uzaslan, EK, Babaoglu, E, Bahadir, A, Baris, SA, Ugurlu, AO, Ilgazli, AH, Fidan, F, Kararmaz, E, Guzel, A, Alzafer, S, Cortuk, M, Hocanli, I, Ortakoylu, MG, Erginel, MS, Yaman, N, Erbaycu, AE, Demir, A, Duman, D, Tanriverdi, H, Yavuz, MY, Sertogullarindan, B, Ozyurt, S, Bulcun, E, Yuce, GD, Sariaydin, M, Ayten, O, Bayraktaroglu, M, Tekgul, S, Erel, F, Senyigit, A, Kaya, SB, Ayik, S, Yazici, O, Akgedik, A, Yasar, ZA, Hayat, E, Kalpaklioglu, F, Sever, F, Sarac, P, Ugurlu, E, Kasapoglu, US, Gunluoglu, G, Demirci, NY, Bora, M, Talay, F, Ozkara, B, Yilmaz, MU, Yavsan, DM, Cetinoglu, ED, Balcan, MB, Ciftci, T, Havan, A, Gok, A, and Nizam, M

Abstract

OBJECTIVE: The purpose of this study is to detect the prevalence and the factors associated with influenza and pneumococcal vaccination and outcomes of vaccination during 2013-2014 season in patients with chronic obstructive pulmonary disease (COPD) in Turkey.

Published
2019

13. Does gestational age affect ultrasonographic findings of the hip in preterm newborns? A sonographic study of the early neonatal period

Author

Yilmaz, M. U., Erel, F., Senyigit, A., Sever, F., Sarac, P., Ugurlu, E., Kasapoglu, U. S., Gunluoglu, G., Yavsan, D. M., Cetinoglu, E. D., Balcan, M. B., Ciftci, T., Havan, A., Gok, A., Nizam, M., Ozkara, B., ÖZLÜ, TEVFİK, Aydin, Derya, Tatar, Dursun, Kuyucu, Tulin, ERBOY, FATMA, İNÖNÜ KÖSEOĞLU, HANDAN, Anar, Ceyda, Sünnetçioğlu, Aysel, Gulhan, Pinar Yildiz, BÜLBÜL, YILMAZ, Okutan, O., Yildiz, B. P., Cetinkaya, P. D., Arslan, S., Cakmak, G., Cirak, A. K., Yakar, F., Kirkil, G., Baccioglu, A., Gedik, C., Sahin, Unal, EKİCİ, AYDANUR, Duru, Serap, Ulasli, Sevinc Sarinc, Kurtipek, Ercan, Gunay, Sibel, Dalli, A., Sarioglu, N., Kocak, N. D., Akturk, U. A., Demir, M., Kilic, T., Hezer, H., Altintas, N., Acat, M., Dagli, C. E., Kargi, A., Karadeniz, G., Intepe, Y. S., Onyilmaz, T., Saylan, B., Baslilar, S., Sariman, N., Ozkurt, S., Arinc, S., Kanbay, A., Yazar, E. E., Yildirim, Z., Kadioglu, E. E., Gul, S., Sengul, A., Berk, S., Dikis, O. S., Bahadir, A., Baris, S. A., Ugurlu, A. O., Ilgazli, A. H., Ortakoylu, M. G., Erginel, M. S., Yaman, N., Arslan, Y., Kurt, O. K., Erol, S., Korkmaz, C., Balaban, A., Erbay, Toru U., Sogukpinar, O., Uzaslan, E. K., Babaoglu, E., Fidan, F., Kararmaz, E., Guzel, A., Alzafer, S., Cortuk, M., Hocanli, I, Tanriverdi, H., Yavuz, M. Y., Sertogullarindan, B., Ozyurt, S., Erbaycu, A. E., Demir, A., Duman, D., Kaya, S. B., Ayik, S., Yazici, O., Akgedik, A., Yasar, Z. A., Hayat, E., Kalpaklioglu, F., Demirci, N. Y., Bora, M., Talay, F., Bulcun, E., Yuce, G. D., Sariaydin, M., Ayten, O., Bayraktaroglu, M., Tekgul, S., and BURSAL DURAMAZ, BURCU

Subjects
musculoskeletal diseases, Male, medicine.medical_specialty, Birth weight, Gestational Age, 03 medical and health sciences, 0302 clinical medicine, Neonatal Screening, Medicine, Humans, Orthopedics and Sports Medicine, Hip Dislocation, Congenital, Retrospective Studies, Ultrasonography, 030222 orthopedics, Developmental dysplasia, business.industry, Obstetrics, Infant, Newborn, Gestational age, Retrospective cohort study, Early neonatal period, Duramaz A., BURSAL DURAMAZ B., Bilgili M. G. , -Does gestational age affect ultrasonographic findings of the hip in preterm newborns? A sonographic study of the early neonatal period-, JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B, cilt.28, ss.107-110, 2019, Pediatrics, Perinatology and Child Health, Gestation, Female, business, 030217 neurology & neurosurgery, Infant, Premature
Abstract

There are only a few studies in the literature investigating the effects of gestational age on developmental dysplasia of the hip. The aim of this study was to investigate the effects of gestational age on hip ultrasound findings in the early neonatal period in preterm newborns born between 30th and 36th weeks of gestational age. Between January 2008 and December 2013, a total of 788 hips of 394 premature newborns with a gestational age of up to 36th weeks who underwent hip ultrasonography in the first week of their life were retrospectively examined. The distribution of roof angles and hip types in terms of sexes was compared between groups. Birth weight, birth height, a, and beta angles were analyzed in terms of the gestational age. The mean gestational age was 33.07 weeks (SD 2.09; between 30th and 36th). Six hundred and seven hips were classified as type I, 154 as type IIa, 21 as type IIc, and 6 as type III. In the 30th week, type IIc hips in females and type III hips in males were statistically significantly higher (P=0.001). In the 34th week, type IIc hips in males were statistically significantly higher than the females (P=0.013). In the 35th week, type IIa hips in females hips were statistically significantly higher than the males (P=0.008). Among all preterm infants, type IIc hips were more common in the 30th, 31st, 32nd, and 34th weeks, whereas type III hips were statistically significantly more common in the 30th week (P=0.0001). The 30th, 31st, 32nd, and 34th weeks of age are gestational ages that should be considered in terms of dysplastic and subluxed hips in premature newborns. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.

Published
2018

14. The association between the prevalence of restless leg syndrome

Author

Turk, AC, Ozkurt, S, Turgal, E, and Sahin, F

Subjects
mental disorders
Abstract

Objective: To determine the prevalence of restless legs syndrome (RLS) in patients with chronic renal failure (CRF) and to compare CRF patients with or without RLS in terms fatigue and sleep quality. Methods: A cross-sectional study was conducted on 220 patients (18-75 years) who were undergoing dialysis 3 times weekly in Corum Province, Corum, Turkey, between January 2014 and January 2016. The diagnosis of RLS was based on the diagnostic form proposed by the international RLS study group. Sleep quality was evaluated using the Pittsburgh sleep quality index (PSQI), and severity of fatigue was determined by using fatigue severity scale (FSS). Results: Of all the participants, 16.8% (n=37) (Group 1) were found to have RLS, while 183 patients had no RLS (Group 2). The mean ages were similar between groups. With respect to laboratory analyses, a p-value of

Published
2018

15. Relationship between hematological examination, glucose, HbA(1c) level

Author

Ugurlu, E, Can, I, Erturk, MS, Akbudak, IH, Dursunoglu, N, and Ozkurt, S

Subjects
stomatognathic system, Diabetes mellitus, glucose, hypoxia, obstructive sleep apnea syndrome, nervous system diseases, respiratory tract diseases
Abstract

OBJECTIVE: Obstructive sleep apnea syndrome (OSAS) is an episodic disease that is characterized by intermittent partial interruption of breathing during sleep, which results in low oxygen levels in organs and tissues. The characteristic symptoms of OSAS include snoring, apnea or hypopnea, and excessive daytime sleepiness. Our aim is to determine the early diagnosis of diabetes and to initiate treatments for OSAS patients according to the results of polysomnography (PSG) in the sleep polyclinic based on fasting blood glucose and HbA1c levels in patients with known OSAS without diabetes.

Published
2018

16. Prevalence of sleep disorders in the Turkish adult population epidemiology of sleep study

Author

Demir A.U., Ardic S., Firat H., Karadeniz D., Aksu M., Ucar Z.Z., Sevim S., Ozgen F., Yilmaz H., Itil O., Peker Y., Aygul F., Kiran S., Gelbal S., Cepni Z., Akozer M., Neyal A., Cilli A., Ozsancak A., Kutlu A., Salepci B., Baklan B., Oktay B., Tuncel D., Levent E., Ekinci E., Eyuboglu F., Yildiz F., Kirbas G., Kaynak H., Aydin H., Boyaci H., Bora I., Oztura I., Aslan K., Gunhan K., Habesoglu M.A., Unlu M., Demet M., Dursunoglu N., Tascilar N., Yavuz N., Erdinc O., Araz O., Dogan O.T., Yetkin O., Celik P., Alp R., Altin R., Bilgin S., Ismailogullari S., Gazioglu S., Ozkurt S., Velioglu S., Yetkin S., Kuyucu T., Atay T., Uygunoglu U., Tutar U., Celik Y., Bulbul Y., Demir, A.U., Department of Chest Diseases, Hacettepe University, Ankara, Turkey -- Ardic, S., Department of Occupational Health and Medicine, Institute of Public Health, Hacettepe University, Ankara, Turkey -- Firat, H., Department of Educational Sciences, Hacettepe University, Ankara, Turkey -- Karadeniz, D., Department of Chest Diseases, Ministry of Health Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey -- Aksu, M., Sleep Disorders Diagnosis and Treatment Center, Ministry of Health Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey -- Ucar, Z.Z., Department of Psychiatry, Gulhane Military Academy of Medicine, Ankara, Turkey -- Sevim, S., Epidemiology Unit, Refik Saydam National Public Health Agency, Ankara, Turkey -- Ozgen, F., Ankara, Turkey -- Yilmaz, H., Department of Neurology, Cerrahpasa University, Istanbul, Turkey -- Itil, O., Department of Neurology, Erciyes University, Kayseri, Turkey -- Peker, Y., Department of Pulmonary Diseases, Dr Suat Seren Chest Diseases and Surgery Training and Research Hospital, Izmir, Turkey -- Aygul, F., Department of Chest Diseases, Dokuz Eylül University, Izmir, Turkey -- Kiran, S., Department of Neurology, Mersin University, Mersin, Turkey -- Gelbal, S., Department of Neurology, Celal Bayar University, Manisa, Turkey -- Cepni, Z., Department of Neurology, Celal Bayar University, Manisa, Turkey -- Akozer, M., Department of Emergency and Cardiovascular Medicine, Sahlgrenska Academy, University of Gothenburg and Sleep Medicine Unit, Skaraborg Hospital, Skövde, Sweden -- Neyal, A., Gaziantep Cengiz Gokcek State Hospital, Gaziantep, Turkey -- Cilli, A., Department of Chest Diseases, Akdeniz University, Antalya, Turkey -- Ozsancak, A., Department of Chest Diseases, Baskent University, Adana, Turkey -- Kutlu, A., Department of Neurology, Kocaeli University, Kocaeli, Turkey -- Salepci, B., Department of Chest Diseases, Ministry of Health KartalTraining and Research Hospital Sleep Center, Istanbul, Turkey -- Baklan, B., Department of Neurology, 9 Eylul University Faculty of Medicine, Hospital, Izmir, Turkey -- Oktay, B., Mardin State Hospital, Mardin, Turkey -- Tuncel, D., Department of Neurology, Kahramanmaras University, Kahramanmaras, Turkey -- Levent, E., Department of Chest Diseases, Maltepe University, Istanbul, Turkey -- Ekinci, E., Department of Chest Diseases, Gaziantep University, Gaziantep, Turkey -- Eyuboglu, F., Department of Chest Diseases, Baskent University, Adana, Turkey -- Yildiz, F., Department of Neurology, Kocaeli University, Kocaeli, Turkey -- Kirbas, G., Department of Chest Diseases, Dicle University, Diyarbakir, Turkey -- Kaynak, H., Department of Neurology, Cerrahpasa Faculty of Medicine, Istanbul, Turkey -- Aydin, H. -- Boyaci, H., Department of Neurology, Uludag University, Bursa, Turkey -- Bora, I., Department of Neurology, Cukurova University, Adana, Turkey -- Oztura, I., Department of Neurology, 9 Eylul University Faculty of Medicine, Hospital, Izmir, Turkey -- Aslan, K., Department of Otorhinolaryngology, Celal Bayar University, Manisa, Turkey -- Gunhan, K., Department of Chest Diseases, Afyon Kocatepe University, Afyon, Turkey -- Habesoglu, M.A., Department of Psychiatry, Celal Bayar University, Manisa, Turkey -- Unlu, M., Department of Psychiatry, Gulhane Military Medical Academy, Ankara, Turkey -- Demet, M., Department of Chest Diseases, Pamukkale University, Denizli, Turkey -- Dursunoglu, N., Department of Neurology, Bulent Ecevit University, Zonguldak, Turkey -- Tascilar, N., Corlu, Tekirdag, Turkey -- Yavuz, N., Department of Neurology, Osmangazi University, Eskisehir, Turkey -- Erdinc, O., Department of Chest Diseases, Rize State Hospital, Rize, Turkey -- Araz, O., Department of Chest Diseases, Cumhuriyet University, Sivas, Turkey -- Dogan, O.T., Department of Chest Diseases, Inonu University, Malatya, Turkey -- Yetkin, O., Department of Chest Diseases, Celal Bayar University, Manisa, Turkey -- Celik, P., Department of Neurology, Kafkas University, Kars, Turkey -- Alp, R., Samsun Chest Diseases Hospital, Samsun, Turkey -- Altin, R., Department of Neurology, Karadeniz Technical University, Trabzon, Turkey -- Bilgin, S., Department of Neurology, Erciyes University, Kayseri, Turkey -- Ismailogullari, S., Department of Psychiatry, Gulhane Military Medical Academy, Ankara, Turkey -- Gazioglu, S., Department of Neurology, Bulent Ecevit University, Zonguldak, Turkey -- Ozkurt, S., Department of Neurology, Bulent Ecevit University, Zonguldak, Turkey -- Velioglu, S., Department of Psychiatry, Gulhane Military Medical Academy, Ankara, Turkey -- Yetkin, S., Ministry of Health Sureyya Pasa Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey -- Kuyucu, T., Ministry of Health Bakirkoy Prof., Mazhar Osman Bakirkoy, Psychiatry Training and Research Hospital, Istanbul, Turkey -- Atay, T., Suruc State Hospital, Suruc, Sanliurfa, Turkey -- Uygunoglu, U., Department of Neurology, Trakya University, Edirne, Turkey -- Tutar, U., Samsun Chest Diseases Hospital, Samsun, Turkey -- Celik, Y., Department of Neurology, Trakya University, Edirne, Turkey -- Bulbul, Y., Department of Psychiatry, Gulhane Military Medical Academy, Ankara, Turkey, and Maltepe Üniversitesi

Subjects
Aging, age distribution, insomnia, sex difference, prevalence, Article, sleep disordered breathing, male, mental disorders, controlled study, human, sleep disorder, adult, questionnaire, daytime somnolence, Sleep disorders, Epworth sleepiness scale, major clinical study, Turkish citizen, aged, female, priority journal, risk factor, restless legs syndrome, Epidemiology and public health, snoring
Abstract

Blackwell Publishing, Sleep disorders constitute an important public health problem. Prevalence of sleep disorders in Turkish adult population was investigated in a nationwide representative sample of 5021 Turkish adults (2598 women and 2423 men, response rate: 91%) by an interviewer-administered questionnaire. Insomnia was defined by the DSM-IV criteria, habitual snoring and risk for sleep-related breathing disorders (SDB) by the Berlin questionnaire, excessive daytime sleepiness (EDS) by the Epworth sleepiness scale score, and restless legs syndrome (RLS) by the complaints according to the International Restless Legs Syndrome Study Group criteria. Mean age of the participants was 40.7 ± 15.1 (range 18 to 90) years. Prevalence rates (men/women) were insomnia 15.3% (10.5%/20.2%; P < 0.001), high probability of SDB 13.7% (11.1%/20.2%; P < 0.001), EDS 5.4% (5.0%/5.7%; P: 0.09), RLS 5.2% (3.0%/7.3%; P < 0.001). Aging and female gender were associated with higher prevalence of sleep disorders except for habitual snoring. Prevalence rates of the sleep disorders among Turkish adults based on the widely used questionnaires were close to the lower end of the previous estimates reported from different parts of the world. These findings would help for the assessment of the health burden of sleep disorders and addressing the risk groups for planning and implementation of health care. Sleep and Biological Rhythms © 2015 Japanese Society of Sleep Research., Demir, A.U.; Department of Chest Diseases, Hacettepe UniversityTurkey

Published
2015

17. Painful and painless shoulder Magnetic Resonance Imaging comparisons in

Author

Turk, AC, Fidan, N, Ozcan, O, Ozdemir, F, Tomak, L, Ozkurt, S, and Sahin, F

Subjects
musculoskeletal diseases, Imaging, shoulder pain, Amyloidosis, beta 2 microglobulin, haemodialysis, Magnetic Resonance, human activities
Abstract

BACKGROUND: Shoulder pain is frequently observed in haemodialysis patients.

Published
2017

19. Painful and painless shoulder magnetic resonance imaging comparisons in hemodialysis patients and correlation with clinical findings

Author

Turk AC, Fıdan N, Ozcan O, Ozdemır F, Tomak L, Ozkurt S, and Sahın F

Subjects
musculoskeletal diseases, musculoskeletal system
Abstract

BACKGROUND: Shoulder pain is frequently observed in haemodialysis patients. OBJECTIVE: To compare haemodialysis patients with or without shoulder pain in terms of shoulder motion ranges, β2 microglobulin levels and magnetic resonance imaging findings. METHODS: Forty-three patients undergoing dialysis were enrolled, of which 23 patients had explicit shoulder pain at night, which appeared during dialysis. Range of joint motion and impingement tests were evaluated. β 2 microglobulin value was recorded. MRI was used to evaluate rotator cuff tendons for thickness, homogeneity, integrity and presence of effusion. RESULTS: Ranges of motion were significantly lower in the painful shoulder group. Supraspinatus tendon thickness and the number of areas with effusion were higher in the painful group. There was a positive correlation between the β 2 microglobulin level and supraspinatus (r:0.352 p< 0.05) and subscapular (r:0.454 p< 0.05) tendon thicknesses. While effusion areas and pain (r:0.351 p< 0.05) showed positive correlation, there was a negative correlation between pain and shoulder motion ranges. CONCLUSIONS: Shoulder pain in dialysis patients can be related with tendon thickness and effusion. While the β 2 microglobulin level affects tendon thickness, it has no relation to pain and movement constraint.

Published
2016

20. Effect of arteriovenous fistula and usage of arm with fistula on bone

Author

Turk, AC, Sahin, F, Ozkurt, S, Tomak, L, and Guray, G

Subjects
musculoskeletal diseases, osteoporosis, hemodialysis, Arteriovenous fistula, exercise, measurement of bone density, musculoskeletal system
Abstract

We aimed to determine the incidence of osteoporosis in hemodialysis patients, to evaluate the differences due to arteriovenous fistula on bone mineral density (BMD) and to investigate whether usage of arm with fistula has an effect on BMD. In this cross-sectional study, 96 patients with chronic renal disease undergone to dialysis were included. Place of fistula (radial and brachial) and dominant hand were recorded. All patients were asked to complete Likert's scale in order to determine the frequency of their usage of arm with fistula. Patients were assigned in two groups: age >51 and < 50years. Age-matched control group included 60 subjects. BMD measurements were done on lumbar vertebra, femur and both forearms. BMD measurement of proximal femur and total radius were significantly lower in patients >50years compared to healthy controls and bone density measurement of lumbar vertebra, proximal femur, 1/3 distal and total radius were significantly lower in patients < 50years compared to healthy controls (p < 0.05). BMD measurement was significantly lower in arms with fistula, especially with radial fistula, compared to both arms without fistula and healthy controls (p < 0.05). When all patients were evaluated, BMD scores were lowering by increasing age, duration of dialysis and fistula and decreasing usage of arm with fistula. BMD in hemodialysis patients is lower than normal population. BMD of arm with fistula is lower than arm without fistula and healthy controls. Both radial and brachial fistula affect negatively ipsilateral BMD. Movement of arm with fistula has positive effects on BMD.

Published
2016

22. Assessment of Palliative Care in Lung Cancer in Turkey

Author

Bülbül, Y., primary, Ozlu, T., additional, Arinc, S., additional, Ozyurek, B.A., additional, Gunbatar, H., additional, Senturk, A., additional, Bahadir, A., additional, Ozcelik, M., additional, Yilmaz, U., additional, Akbay, M.O., additional, Saglam, L., additional, Kilic, T., additional, Kirkil, G., additional, Ozcelik, N., additional, Tatar, D., additional, Baris, S.A., additional, Yavsan, D.M., additional, Sen, H.S., additional, Berk, S., additional, Acat, M., additional, Cakmak, G., additional, Yumuk, P.F., additional, Intepe, Y.S., additional, Toru, U., additional, Ayik, S.O., additional, Basyigit, I., additional, Ozkurt, S., additional, Mutlu, L.C., additional, Yasar, Z.A., additional, Esme, H., additional, Erol, M.M., additional, Oruc, O., additional, Erdoğan, Y., additional, Asker, S., additional, Ulas, A., additional, Erol, S., additional, Kerget, B., additional, Erbaycu, A.E., additional, Teke, T., additional, Beşiroğlu, M., additional, Can, H., additional, Dalli, A., additional, and Talay, F., additional

Published
2016
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23. Turkish Textile Dyeing Factories

Author

Ozkurt, S, Kargi, BA, Kavas, M, Evyapan, F, Kiter, G, and Baser, S

Subjects
textile dyes, respiratory symptoms, pulmonary function test
Abstract

Dyes are known to be a causative agent of occupational asthma in workers exposed to them. We have evaluated respiratory symptoms among textile workers. The study population comprised 106 exposed workers and a control (unexposed) group. Data were collected by a questionnaire. PFTs (Pulmonary Function Test) were performed. Among the exposed workers 36.8% defined phlegm. Respiratory symptoms were not significantly different between two groups. The employment duration of the exposed workers with phlegm was longer than those without phlegm (p = 0.027). The mean % predicted of FEF25-75 of the exposed workers was found to be significantly lower than the control (unexposed) group (p = 0.01). Our study suggests that textile dyeing might cause respiratory symptoms in workers.

Published
2012

24. Respiratory symptoms and pulmonary functions of workers employed in Turkish textile dyeing factories

Author

Ozkurt S, Kargi BA, Kavas M, Evyapan F, Kiter G, and Baser S

Subjects
Adult, Coloring Agents, Female, Humans, Lung Diseases/*epidemiology/physiopathology, Male, Occupational Diseases/*epidemiology/physiopathology, Occupational Exposure/*adverse effects, Respiratory Function Tests, Textiles, Turkey/epidemiology, Young Adult
Abstract

Dyes are known to be a causative agent of occupational asthma in workers exposed to them. We have evaluated respiratory symptoms among textile workers. The study population comprised 106 exposed workers and a control (unexposed) group. Data were collected by a questionnaire. PFTs (Pulmonary Function Test) were performed. Among the exposed workers 36.8% defined phlegm. Respiratory symptoms were not significantly different between two groups. The employment duration of the exposed workers with phlegm was longer than those without phlegm (p = 0.027). The mean % predicted of FEF(25-75) of the exposed workers was found to be significantly lower than the control (unexposed) group (p = 0.01). Our study suggests that textile dyeing might cause respiratory symptoms in workers.

Published
2012

25. Is the clinical presentation different between men and women admitting to the sleep laboratory?

Author

Dursunoglu N, Ozkurt S, and Sarikaya S

Subjects
Body Mass Index, Disorders of Excessive Somnolence/diagnosis/epidemiology, Female, Headache/epidemiology, Humans, Laboratories, Male, Middle Aged, Patient Admission/*statistics & numerical data, Polysomnography/*methods, Prevalence, Severity of Illness Index, Sleep Apnea Syndromes/epidemiology, Sleep Apnea, Obstructive/*diagnosis/*epidemiology, Sleep Wake Disorders/diagnosis/epidemiology, respiratory tract diseases
Abstract

OBJECTIVES: Sleep and sleep disorders are different in several important ways between men and women. We aimed to investigate gender differences in initial symptoms and associating medical diseases of patients admitting to our sleep clinic. METHODS: Ninety-one patients, 20 women (22%) and 71 men (78%), admitting consecutively to the sleep clinic were studied. A detailed sleep and medical history of the patients was recorded. All patients were questioned for Epworth Sleepiness Scale (ESS) and underwent an entire night of diagnostic polysomnography. Apnea-hypopnea index (AHI) was identified as the total number of apnea and hypopnea per hour of sleep. Hypopnea was defined as a decrease of airflow by at least 50% and desaturations were defined as >or=4% decrease in oxygen saturation. RESULTS: The mean values for age, body mass index, blood pressures and ESS score did not significantly differ between men and women, but AHI (events/h) was significantly higher in men (29.1 +/- 22.7) than women (17.9 +/- 17.7, p < 0.05). Snoring was the most common symptom in both men (95%) and women (90%). Among the main presenting complaints, only morning headache (12 of women 60%, 31 of men 43%, p = 0.04) and dry mouth on awakening (ten of women 50%, 57 of men 80%, p = 0.02) showed a significant difference between the two genders, while among the medical diseases only hypothyroidism (four of women 20% and three of men 4%, p = 0.03) and depression (nine of women 45% and 16 of men 22%, p = 0.02) were seen as statistically higher in women than in men. CONCLUSIONS: Primary care physicians should be aware of obstructive sleep apnea (OSA) in women and the importance of referring women for sleep studies when they complain of symptoms associated with OSA, even if other non-specific symptoms such as morning headaches are reported. Also, hypothyroidism and depression are accompanied with sleep disorders especially in women.

Published
2009

26. a multicentre cross-sectional study in adults

Author

Kurt, E, Metintas, S, Basyigit, I, Bulut, I, Coskun, E, Dabak, S, Deveci, F, Fidan, F, Kaynar, H, Uzaslan, EK, Onbasi, K, Ozkurt, S, Karakis, GP, Sahan, S, Sahin, U, Oguzulgen, K, Yildiz, F, Mungan, D, Yorgancioglu, A, Gemicioglu, B, and Kalyoncu, AF

Subjects
Allergy, asthma, prevalence, risk factors, Turkey
Abstract

The Prevalence and Risk Factors of Allergies in Turkey (PARFAIT) study was planned to evaluate the prevalence of and risk factors for asthma and allergic diseases in Turkey. The present analysis used data from 25,843 parents of primary school children, obtained from a cross-sectional questionnaire-based study. A total of 25,843 questionnaires from 14 centres were evaluated. In rural areas, the prevalences asthma, wheezing, allergic rhinitis and eczema in males were: 8.5% (95% confidence interval (CI) 7.9-9.1%), 13.5% (95% Cl 12.8-14.2%), 17.5% (95% Cl 16.7-18.2%) and 10.8% (95% Cl 10.2-11.4%), respectively; and in females were: 11.2% (95% Cl 10.9-11.8%), 14.7% (95% Cl 14.3-15.1%), 21.2% (95% Cl 20.4-22.0%) and 13.1% (95% Cl 12.4-13.8%), respectively. In urban areas, the corresponding prevalences in males were: 6.2% (95% Cl 5.8-6.6%), 10.8% (95% Cl 10.3-11.3%), 11.7% (95% Cl 11.4-12.0%) and 6.6% (95% Cl 6.2-7.0%), respectively; and in females were: 7.5% (95% Cl 7.9-7.1%), 12.0% (95% Cl 11.7-12.3%), 17.0% (95% Cl 16.4-17.6%) and 7.3% (95% Cl 6.9-7.7%), respectively. Having an atopic first-degree relative or any other atopic diseases had significant effects on the prevalence of allergic diseases. Housing conditions, such as living in a shanty-type house, visible moulds at home and use of wood or biomass as heating or cooking material were associated with one or more allergic diseases. Although genetic susceptibility is strongly associated, country- and population-based environmental factors may contribute to increased prevalence rates of allergic diseases.

Published
2009

27. Is the clinical presentation different between men and women admitting

Author

Dursunoglu, N, Ozkurt, S, and Sarikaya, S

Subjects
Obstructive sleep apnea, Symptoms, Gender, Sleep disorders, respiratory tract diseases
Abstract

Sleep and sleep disorders are different in several important ways between men and women. We aimed to investigate gender differences in initial symptoms and associating medical diseases of patients admitting to our sleep clinic. Ninety-one patients, 20 women (22%) and 71 men (78%), admitting consecutively to the sleep clinic were studied. A detailed sleep and medical history of the patients was recorded. All patients were questioned for Epworth Sleepiness Scale (ESS) and underwent an entire night of diagnostic polysomnography. Apnea-hypopnea index (AHI) was identified as the total number of apnea and hypopnea per hour of sleep. Hypopnea was defined as a decrease of airflow by at least 50% and desaturations were defined as a parts per thousand yen4% decrease in oxygen saturation. The mean values for age, body mass index, blood pressures and ESS score did not significantly differ between men and women, but AHI (events/h) was significantly higher in men (29.1 +/- 22.7) than women (17.9 +/- 17.7, p < 0.05). Snoring was the most common symptom in both men (95%) and women (90%). Among the main presenting complaints, only morning headache (12 of women 60%, 31 of men 43%, p = 0.04) and dry mouth on awakening (ten of women 50%, 57 of men 80%, p = 0.02) showed a significant difference between the two genders, while among the medical diseases only hypothyroidism (four of women 20% and three of men 4%, p = 0.03) and depression (nine of women 45% and 16 of men 22%, p = 0.02) were seen as statistically higher in women than in men. Primary care physicians should be aware of obstructive sleep apnea (OSA) in women and the importance of referring women for sleep studies when they complain of symptoms associated with OSA, even if other non-specific symptoms such as morning headaches are reported. Also, hypothyroidism and depression are accompanied with sleep disorders especially in women.

Published
2009

28. Cryptogenic organizing pneumonia: Two cases and an update

Author

Kiter, G, Yuncu, G, Bir, F, Karabulut, N, Ozkurt, S, and Evyapan, F

Subjects
bronchiolitis obliterans organizing pneumonia, cryptogenic organizing pneumonia, interstitial lung disease, idiopathic
Abstract

Cryptogenic organizing pneumonia, a unique clinicopathologic entity, is a current and many faceted issue due to its terminological equivalents and differential diagnostic features according to various clinics. Our first case with organizing pneumonia was diagnosed via transbronchial lung biopsy, performed for bilateral pulmonary consolidations unresolved by antibiotic treatment. The second case, who had a left lower lobe mass, was diagnosed by thoracotomy carried out due to a preliminary diagnosis of malignancy. Both cases were considered as "Cryptogenic" organizing pneumonia since no underlying factors could be related and a long term follow-up was achieved. We aimed to review the current literature together with a presention of the clinical, radiological and histopathological findings of our two cases.

Published
2008

29. Peak expiratory flow monitoring to screen for asthma in patients with allergic rhinitis

Author

Baser S, Ozkurt S, Topuz B, Kiter G, Karabulut H, Akdag B, and Evyapan F

Subjects
circadian rhythm, Adult, Male, corticosteroid, lung function test, peak expiratory flow, prick test, Peak Expiratory Flow Rate, nose polyp, Allergic rhinitis, mite, immune system diseases, Hypersensitivity, Humans, controlled study, human, Prospective Studies, airway obstruction, Skin Tests, questionnaire, Peak expiratory flow (PEF), article, Rhinitis, Allergic, Seasonal, asthma, Middle Aged, major clinical study, respiratory tract diseases, female, Female, Hypersensitivity/complications/*diagnosis, Rhinitis, Allergic, Seasonal/*complications, Peak flow meter
Abstract

Aim: To investigate the benefit of using peak expiratory flow (PEF) monitoring to screen for asthma in allergic rhinitis patients. Methods: Eighty-nine consecutive patients with allergic rhinitis but never assessed for asthma were included in this prospective study. Their allergic status was determined by skin prick tests. All of the subjects filled in a questionnaire on asthma-like symptoms. If they reported such symptoms, pulmonary function tests were carried out. Then, PEF was checked twice daily for 3 weeks. Results: Thirty-six percent of our study group were male and 64% were female patients with a mean (SD) age of 36.3 (14.0) years. Skin prick tests were positive to grass mixture in 71 (79.8%) patients, to tree mixture in 51 (57.3%), to mite in 46 (51.7%), and to epidermal mix in 26 (29.2%) patients. Thirty-six patients (41%) reported 3 or more asthma symptoms. Lung function test results for these 36 patients showed obstruction for 11.1% (4 patients); the remaining patients (88.9%) had normal function parameters. The subjects who reported 3 or more asthma symptoms but had normal lung function monitored their PEF for 3 weeks. Sixteen (50%) patients from this group and the 4 patients with demonstrated airway obstruction had more than 20% diurnal variation in PEF. These 20 patients' asthma symptoms disappeared after they received 3 months of low-dose inhaled corticosteroid therapy. Conclusion: It is necessary to look for asthma in patients suffering from allergic rhinitis. PEF monitoring is a low-cost, objective approach to asthma diagnosis that can be performed by a patient with allergic rhinitis even if spirometry is normal. Knowledge of this technique is of utmost importance because delay in diagnosis will result in the unsatisfactory treatment of the disease. © 2007 Esmon Publicidad.

Published
2007

30. Peak expiratory flow monitoring to screen for asthma in patients with

Author

Baser, S, Ozkurt, S, Topuz, B, Kiter, G, Karabulut, H, Akdag, B, and Evyapan, F

Subjects
allergic rhinitis, asthma, peak expiratory flow (PEF), peak flow meter, immune system diseases, respiratory tract diseases
Abstract

Aim: To investigate the benefit of using peak expiratory flow (PEF) monitoring to screen for asthma in allergic rhinitis patients. Methods: Eighty-nine consecutive patients with allergic rhinitis but never assessed for asthma were included in this prospective study. Their allergic status was determined by skin prick tests. All of the subjects filled in a questionnaire on asthma-like symptoms. If they reported such symptoms, pulmonary function tests were carried out. Then, PEF was checked twice daily for 3 weeks. Results: Thirty-six percent of our study group were male and 64% were female patients with a mean (SD) age of 36.3 (14.0) years. Skin prick tests were positive to grass mixture in 71(79.8%) patients, to tree mixture in 51 (57.3%), to mite in 46 (51.7%), and to epidermal mix in 26 (29.2%) patients. Thirty-six patients (41%) reported 3 or more asthma symptoms. Lung function test results for these 36 patients showed obstruction for 11.1% (4 patients); the remaining patients (88.9%) had normal function parameters. The subjects who reported 3 or more asthma symptoms but had normal lung function monitored their PEF for 3 weeks. Sixteen (50%) patients from this group and the 4 patients with demonstrated airway obstruction had more than 20% diurnal variation in PEF These 20 patients' asthma symptoms disappeared after they received 3 months of low-dose inhaled corticosteroid therapy. Conclusion: It is necessary to look for asthma in patients suffering from allergic rhinitis. PEF monitoring is a low-cost, objective approach to asthma diagnosis that can be performed by a patient with allergic rhinitis even if spirometry is normal. Knowledge of this technique is of utmost importance because delay in diagnosis will result in the unsatisfactory treatment of the disease.

Published
2007

31. Effects of CPAP on left ventricular structure and myocardial performance

Author

Dursunoglu, N, Dursunoglu, D, Ozkurt, S, Kuru, O, Gur, S, Kiter, G, and Evyapan, F

Subjects
myocardial performance index, left ventricular structure, left, obstructive sleep apnoea, continuous positive airway pressure, ventricular dysfunction, respiratory tract diseases
Abstract

Background: Obstructive sleep apnoea (OSA) has the potential to cause heart failure. We aimed to determine the effects of nasal continuous positive airway pressure (CPAP) therapy on left ventricular structure and myocardial performance index (MPI) in severe OSA patients. Methods: Sixty-seven subjects without any cardiac or pulmonary disease had overnight polysomnography and echocardiography. In 33 males with severe OSA, thickness of interventricular septum (IVS) and posterior wall (LVPW) were measured by M-mode. Left ventricular MPI was calculated as (isovolumic contraction time + isovolumic relaxation time)/aortic ejection time by Doppler. Results: Eight males were non-compliant with CPAP. Mean age was 47.9 +/- 8.2 years, and 20 of 25 patients (80.0%) were hypertensive. Patients had high body mass index (BMI: 31.0 +/- 3.9 kg/m(2)), but there was no change in BMI from baseline after 6 months. Thickness of IVS (11.0 +/- 1.1 mm) and LVPW (11.0 +/- 1.0 mm) at baseline were significantly decreased after 6 months of CPA P therapy (10.5 +/- 0.9 mm, P < 0.001 and 10.4 +/- 0.7 mm, P < 0.0001, respectively). Left ventricular MPI (60.1 +/- 13.8%) significantly decreased (53.0 10.7%, P < 0.0001) after CPAP usage. Conclusions: In male patients with severe OSA, CPAP therapy significantly decreases left ventricular wall thickness and improves global function even with 6 months of usage. (c) 2006 Elsevier B.V. All rights reserved.

Published
2007

32. Respiratory symptoms and pulmonary functions test results in glass - factory workers

Author

Baser, S, Ozkurt, S, Hacioglu, M, Akdag, B, Zencir, M, and Fisekci, FE

Subjects
glass worker, pulmonary function tests, respiratory symptoms, silica, respiratory system, respiratory tract diseases
Abstract

Objective: To determine the prevalence of respiratory symptoms, lung function abnormalities and the prevalence of chronic bronchitis among glass factory workers who were exposed to silica-cyrstal. Material and Method: 37 female (23.4%) and 121 male (76.6%) total 158 workers (mean age SD: 27.65 +/- 8.64 years) employed in glass factory were studied. All of the workers filled a questionnaire for their respiratory symptoms. Their pulmonary function tests (PFT) were determined by a portable spirometry. Their respiratory symptoms and PFT results were compared with a control group who has similar age, sex, and smoking habit. Results: The mean duration of employment of workers was 60.32 +/- 86.64 months. The workers had high prevalence of cough (19%), phlegm (23%), wheezing (25%) and dyspnea (16%) when compared to control group (p=0.052, p=0.002, p=0.0001, p=0.013, respectively). The workers had lower FEV1%, FVC%, PEF% ve FEF25-75% results compared to the control group (p=0.001, p=0.0001, p=0.0001, p=0.007, respectively). The prevalence of respiratory symptoms and PFT results were not significantly different between departments of the factory. A negative correlation was found between FEV1% and duration of employment (r=-0.214, p=0.007). Conclusion: Increased respiratory symptoms and reduced PFT results were found amongst glass-factory workers. This population is under increased risk of occupational chronic bronchitis. Taking precautions for workers' health, training workers against occupational diseases, and regular check ups will provide those workers' well-being.

Published
2007

33. Effects of CPAP on left ventricular structure and myocardial performance index in male patients with obstructive sleep apnoea

Author

Dursunoglu N, Dursunoglu D, Ozkurt S, Kuru O, Gür S, Kiter G, and Evyapan F

Subjects
Body Mass Index, Continuous Positive Airway Pressure/*methods, Disorders of Excessive Somnolence/diagnosis/epidemiology, Electrocardiography, Humans, Male, Middle Aged, Myocardium, Polysomnography, Respiratory Function Tests, Severity of Illness Index, Sleep Apnea, Obstructive/diagnosis/epidemiology/*therapy, Ventricular Dysfunction, Left/diagnosis/epidemiology/*physiopathology, respiratory tract diseases
Abstract

BACKGROUND: Obstructive sleep apnoea (OSA) has the potential to cause heart failure. We aimed to determine the effects of nasal continuous positive airway pressure (CPAP) therapy on left ventricular structure and myocardial performance index (MPI) in severe OSA patients. METHODS: Sixty-seven subjects without any cardiac or pulmonary disease had overnight polysomnography and echocardiography. In 33 males with severe OSA, thickness of interventricular septum (IVS) and posterior wall (LVPW) were measured by M-mode. Left ventricular MPI was calculated as (isovolumic contraction time+isovolumic relaxation time)/aortic ejection time by Doppler. RESULTS: Eight males were non-compliant with CPAP. Mean age was 47.9+/-8.2 years, and 20 of 25 patients (80.0%) were hypertensive. Patients had high body mass index (BMI: 31.0+/-3.9 kg/m(2)), but there was no change in BMI from baseline after 6 months. Thickness of IVS (11.0+/-1.1mm) and LVPW (11.0+/-1.0mm) at baseline were significantly decreased after 6 months of CPAP therapy (10.5+/-0.9 mm, P

Published
2007

34. Severe sleep apnea syndrome diagnosed with acute myocardial infarction

Author

Dursunoglu N, Dursunoglu D, Ozkurt S, Tanriverdi H, Evrengül H, and Kiter G

Subjects
Humans, Male, Middle Aged, Myocardial Infarction/diagnosis/*etiology/therapy, Sleep Apnea Syndromes/*complications/diagnosis/therapy, respiratory tract diseases
Abstract

A 55-year-old man with acute myocardial infarction and no heart failure, had episodes of severe oxygen desaturation and apnea, while his hemodynamic parameters were stable. Sleep recordings revealed severe sleep apnea, and pulmonary function tests showed bronchial obstruction. Apnea and desaturation resolved on bi-level positive airway pressure. Patients with acute myocardial infarction who have apnea and hypoxemia without evident heart failure should be evaluated for sleep disorders.

Published
2007

35. [Differences between men and women in the clinical and laboratory findings of patients diagnosed with pulmonary embolism]

Author

Dursunoğlu N, Başer S, Dursunoğlu D, Moray A, Kiter G, Ozkurt S, Evyapan F, and Karabulut N

Subjects
Aged, Blood Gas Analysis, Echocardiography, Electrocardiography, Female, Gender Identity, Humans, Male, Middle Aged, Pulmonary Embolism/blood/diagnostic imaging/*mortality/pathology/*physiopathology, Risk Factors, Severity of Illness Index, Sex Factors, Tomography, X-Ray Computed, Turkey/epidemiology
Abstract

Pulmonary embolism (PE) could not be diagnosed correctly in 2/3 of patients saving of that pathology, and unfortunately mortality in them could be as high as 30%. In the present study, we aimed to investigate the gender differences in clinical, electrocardiography (ECG) and laboratory findings of PE patients diagnosed with contrast-enhanced helical computerized tomography of thorax. 31 patients (18 females, 58% and 13 males, 42%) were included into the study. Symptoms, risk factors, ECG and arterial blood gases were evaluated, and then Wells, Geneva and ECG scores were obtained in each subject. Alveolo-arterial (A-a) oxygen gradient was calculated as P(A-a)O2= 150-(PCO2/0.8)-PO2. Mean pulmonary artery pressure (PAP) was measured by echocardiography. In female and male patients, Wells score (4.8 +/- 1.9 and 3.2 +/- 2.2, p= 0.017); ECG score (5.9 +/- 3.6 and 3.1 +/- 1.8, p= 0.036) and mean PAP (33.5 +/- 12.3 mmHg and 23.2 +/- 10.0 mmHg, p= 0.017) were significantly different. However, between female and male patients Geneva score (4.8 +/- 1.7 and 5.0 +/- 1.6), A-a gradient (35.2 +/- 17.3 and 42.9 +/- 12.3) and PaCO2 (33.5 +/- 15.1 and 29.8 +/- 5.4) did not differ significantly (p> 0.05). Immobilization and surgical interventions as risk factors for PE were established significantly higher in females than males (50%-30.8%, p= 0.02 and 50%-23.1%, p= 0.01). In female patients with PE, Wells and ECG scores, immobilization, surgical interventions and mean PAP are significantly higher than male patients. So, in the clinical practice, these parameters may help to diagnose acute PE especially in females.

Published
2007

36. İşyeri hekimlerinin mesleksel solunum hastalıkları konusunda bilgi ve yaklaşımları

Author

Baser, S, Ozkurt, S, Evyapan, F, Dursunoglu, N, and Zencir, M

Subjects
occupational physicians, occupational respiratory diseases, worker
Abstract

The aim of this study was to evaluate occupational physician's approaches to the diagnosis and treatment of occupational respiratory diseases. Forty-one occupational physicians who were responsible of a total 10,023 workers were evaluated. Questionnaires were performed via interview. Thirty-one male (75%) and 10 female (% 25) physicians with a mean age +/- SD:39.19 +/- 5.18 yr were enrolled in the study. The mean employment time of the physicians at factories was +/- SD:6.3 +/- 3.4 yr. The physicians were working at textile, marble, chemistry and metal factories. For each physician, the mean number of workers that they were responsible for was +/- SD:244.5 +/- 190.9 (50-750). Of the 10,023 workers, 143 were diagnosed as having occupational lung disorders. The prevalence of occupational respiratory diseases was 1.4%. Only 29.3% of the occupational physicians had attended to an occupational diseases course during their employment. The type of the occupational respiratory diseases and the percents were:COPD (37%), Asthma (12%), Acute inhalation damage (10%), hypersensitivity pneumonitis (5%), byssinosis (% 2). Fifty-four percent of the physicians has never diagnosed an occupational disease. Only 4.9% physician had PFT equipment. Preferred treatment options for the occupational respiratory diseases were; Changing the department in the same factory (58%), quit the job (37%), and medical treatment (12%). The knowledge and the equipment of the occupational physicians about the diagnosis and treatment of occupational respiratory diseases are not sufficient. We suggest that additional occupational respiratory courses for occupational physicians may contribute to improvements in the diagnosis and control of occupational respiratory diseases.

Published
2007

37. multicentric cross-sectional study in children

Author

Kurt, E, Metintas, S, Basyigit, I, Bulut, I, Coskun, E, Dabak, S, Deveci, F, Fidan, F, Kaynar, H, Uzaslan, EK, Onbasi, K, Ozkurt, S, Pasaoglu, G, Sahan, S, Sahin, U, Oguzulgen, K, Yildiz, F, Mungan, D, Yorgancioglu, A, Gemicioglu, B, and Kalyoncu, AF

Subjects
allergic diseases, asthma, climate, risk factors, prevalence
Abstract

The Prevalence And Risk Factors of Allergies in Turkey (PARFAIT) study was planned to evaluate prevalence and risk factors of asthma and allergic diseases and also to find out which geographical variables and/or climatic conditions play a role determining the prevalence of allergic diseases in Turkish school children. Study was planned as cross-sectional questionnaire-based. About 25,843 questionnaires from 14 centers were appropriate for analysis. Parental history of allergy, having an atopic sibling and other atopic disease in index case was significant risk factors for all allergic diseases. Breast feeding decreased the risk of current asthma (OR: 0.92, CI: 0.86-0.99) and wheezing (OR: 0.93, CI: 0.87-0.99) but not allergic rhinitis and eczema. Respiratory infection in the past was an important risk factor for the occurrence of allergic diseases especially for asthma which was increased 4.53-fold. Children exposed to household smoke were significantly at higher risk of asthma, wheezing, and allergic rhinitis (OR: 1.20, CI: 1.08-1.33; OR: 1.21, CI: 1.09-1.34; and OR: 1.32, CI: 1.21-1.43, respectively). All allergic diseases were increased in those children living in areas which have altitude of below 1000 m and mean yearly atmospheric pressure above 1000 mb. The study has suggested that household and country-specific environmental factors are associated with asthma, wheezing, allergic rhinitis, and eczema risk during childhood in Turkey. C1 Eskisehir Osmangazi Univ, Asthma & Allergy Working Grp Turkish Thorac Soc, Eskisehir, Turkey. Eskisehir Osmangazi Univ, Dept Publ Hlth, Eskisehir, Turkey. Kocaeli Univ, Dept Pulm Dis, Kocaeli, Turkey. Abant Izzet Baysal Univ, Dept Pulm Dis, Duzce, Turkey. Celal Bayar Univ, Dept Pulm Dis, Manisa, Turkey. Ondokuz Mayis Univ, Dept Publ Hlth, Samsun, Turkey. Firat Univ, Dept Pulm Dis, Elazig, Turkey. Afyon Kocatepe Univ, Dept Pulm Dis, Afyton, Turkey. Ataturk Univ, Dept Pulm Dis, Erzurum, Turkey. Uludag Univ, Dept Pulm Dis, Bursa, Turkey. Yuzuncu Yil Univ, Dept Internal Med, Van, Turkey. Pamukkale Univ, Dept Pulm Dis, Denizli, Turkey. Acibadem Hosp, Istanbul, Turkey. State Hosp, Tarsus, Turkey. Suleyman Demirel Univ, Dept Pulm Dis, Isparta, Turkey.

Published
2007

38. Denizli il merkezinde yaşayan erişkinlerin sigara içme özellikleri

Author

Baser, S, Hacioglu, M, Evyapan, F, Ozkurt, S, Kiter, G, and Zencir, M

Subjects
tobacco, epidemiology, smoking
Abstract

To determine the prevalence of cigarette smoking and to examine the risk factors affecting smoking amongst adults older than 40 years old in the city of Denizli, one thousand two hundred and three people who live in the center of Denizli are included in this cross-sectional study that evaluates prevalence of smoking. Data was gathered by face to face questionnaires. The mean age of 1203 participants (574 males [47.7%] and 629 females [52.3%]) was 52.6 +/- 10.5 years. The prevalence of smoking was 50.3%, 12.1%, and 30.3% amongst males, females and total population, respectively. There was a positive significant relation between education and smoking amongst women (p=0.0001), but this relationship was not significant amongst men. The mean pac-yrs were 32.9 +/- 23.1 and 13.1 +/- 13.8 for males and females, respectively. The prevalence of smoking was higher for the group with well economical status (p=0.026). The ratio of beginning smoking at male and female population before 20 years-old were, 66.7% and 37.5%, respectively (p=0.0001). Males were exposed to passive smoking at work, while females were exposed at home. The prevalence of cigarette smoking was significantly higher in persons whose parents were smokers during their childhood (p=0.001). The prevalence of smoking was similar to Turkey's prevalence of smoking amongst males but lower amongst females and total population. The prevalence of smoking was higher at well educated women, but this relationship was not observed at men. The prevalence of smoking was high among the persons whose parents were smokers during their childhood.

Published
2007

39. thickness in obstructive sleep apnea - Non-invasive indicators of

Author

Tanriverdi, H, Evrengul, H, Kara, CO, Kuru, O, Tanriverdi, S, Ozkurt, S, Kaftan, A, and Kilic, M

Subjects
aortic elastic properties, carotid artery, endothelial function, cardiovascular system, flow-mediated dilatation, intima-media thickness, obstructive sleep, apnea
Abstract

Background and Objective: Obstructive sleep apnea (OSA) has a critical association with cardiovascular mortality and morbidity. Carotid intima-media thickness (IMT), flow-mediated dilatation (FMD) and aortic stiffness are early signs of atherosclerosis. The presence of subclinical atherosclerosis was assessed in OSA patients using these parameters. Methods: 40 patients with OSA showing an apnea-hypopnea index (AHI) >= 5 (mean age 51.3 +/- 9 years, 32 males) and 24 controls ( HI < 5, mean age 51.9 +/- 5.2 years, 19 males) were enrolled in the study. In all subjects, polysomnographic examination and recordings were performed during sleep. IMT of the carotid artery, endothelium-dependent/-independent vasodilation of the brachial artery and aortic elastic parameters were investigated using high-resolution Doppler echocardiography. Results: The demographic data of the patients with OSA and controls were not significantly different. Subjects with OSA demonstrated higher values of aortic stiffness (7.1 +/- 1.88 vs. 6.42 +/- 1.56, respectively) and IMT (0.85 +/- 0.13 vs. 0.63 +/- 0.11 mm, p = 0.0001, respectively) but lower distensibility (9.47 +/- 1.33 vs. 11.8 +/- 3.36 cm(2)/dyn/10(6)) and FMD (4.57 +/- 1.3 vs. 6.34 +/- 0.83%, p = 0.0001, respectively) than the controls. The respiratory disturbance index correlated positively with aortic stiffness and IMT and negatively with distensibility and FMD. Conclusion: We observed blunted endothelium-dependent dilatation, increased carotid IMT and aortic stiffness in patients with OSA compared with matched control subjects. This is evident in the absence of other diseases, suggesting that OSA is an independent cause of atherosclerosis. These simple and noninvasive methods help to detect subclinical atherosclerosis in OSA. Copyright (C) 2006 S. Karger AG, Basel. C1 Pamukkale Univ, Sch Med, Dept Cardiol, Denizli, Turkey. Pamukkale Univ, Sch Med, Dept Otorhinolaryngol, Denizli, Turkey. Pamukkale Univ, Sch Med, Dept Radiol, Denizli, Turkey. Pamukkale Univ, Sch Med, Dept Chest Dis, Denizli, Turkey.

Published
2006

40. Effects of CPAP on right ventricular myocardial performance index in

Author

Dursunoglu, N, Dursunoglu, D, Ozkurt, S, Gur, S, Ozalp, G, and Evyapan, F

Subjects
respiratory tract diseases
Abstract

Objectives: Obstructive sleep apnoea (OSA) might cause right ventricular dysfunction and pulmonary hypertension. We aimed to determine the effects of nasal continuous positive airway pressure (CPAP) therapy on right ventricular myocardial performance index (MPI) in OSA patients without hypertension. Methods: 49 subjects without hypertension, diabetes mellitus, any cardiac and pulmonary disease had overnight polysomnography and echocardiography. In 18 moderate-severe OSA (apnea-hypopnea index >= 15) patients, right ventricular free wall diameter (RVFWD) was measured by M-mode, and right ventricular MPI was calculated as (isovolumic contraction time+isovolumic relaxation time)/pulmonary ejection time using Doppler at baseline and after 6 months CPAP therapy. Results: Mean age was 46.5 +/- 4.9 year. Patients had high body mass index (BMI: 30.6 +/- 4,0 kg/m(2)), but there was no change in either BMI or blood pressures after 6 months. Right ventricular end-diastolic and end-systolic diameters were in normal limits at baseline, and did not change after CPAP usage. Baseline RVFWD (7.1 +/- 2.1 mm) significantly decreased after CPAP therapy (6.2 +/- 1.7 mm, p

Published
2006

41. within Denizli City Center

Author

Daloglu, G, Ozkurt, S, Evyapan, FF, Kiter, G, Zencir, M, and Baser, S

Subjects
asthma, prevalence, symptoms, risk factors
Abstract

Asthma is one of the chronic illnesses most frequently occurred in the world. Its prevalence, morbidity and mortality gradually increase. In Denizli, we aimed to determine the risk factors effecting asthma evolution and the prevalence of symptoms related with asthma in adults in 20-49 age group. ECRHS (European Community Respiratory Health Survey) public survey and an additional form prepared by us have been applied to 2516 people in Denizli city center. The most frequent symptoms were cough causing awakening (17,4%) and wheezing (16,8 %). It was found that asthma attack rate was 1,5% and medicine usage rate because of asthma diagnosis was 2,3%. It was seen that asthma like symptoms become more frequent in the older people, and more frequent in females. For wheezing; being female (ORs (95% CI): 1.61 (1.24-2.09) p

Published
2006

42. two cases

Author

Yuncu, G, Ozkurt, S, Sinik, Z, and Kiter, G

Published
2006

43. Effect of obstructive sleep apnea on aortic elastic parameters: relationship to left ventricular mass and function

Author

Tanriverdi H, Evrengul H, Kaftan A, Kara CO, Kuru O, Tanriverdi S, Ozkurt S, and Semiz E

Subjects
Adult, Aorta/diagnostic imaging/physiopathology, Echocardiography, Doppler, Elasticity, Female, Heart Ventricles/diagnostic imaging/physiopathology, Humans, Male, Middle Aged, Retrospective Studies, Sleep Apnea, Obstructive/complications/diagnostic imaging/*physiopathology, Snoring/complications/diagnostic imaging/physiopathology, Ventricular Function, Left, respiratory tract diseases
Abstract

BACKGROUND: Obstructive sleep apnea (OSA) syndrome has a critical association with cardiovascular mortality and morbidity. Aortic elastic parameters are important markers for left ventricular (LV) function and are deteriorated in cardiovascular disease. METHODS AND RESULTS: Aortic elastic parameters and LV functions and mass were investigated in 40 patients with OSA (apnea - hypopnea index (AHI) >or=5) (mean age 51.3 +/-9 years, 32 males) and 24 controls (AHI

Published
2006

44. Aortic stiffness, flow-mediated dilatation and carotid intima-media thickness in obstructive sleep apnea: non-invasive indicators of atherosclerosis

Author

Tanriverdi H, Evrengul H, Kara CO, Kuru O, Tanriverdi S, Ozkurt S, Kaftan A, and Kilic M

Subjects
Aorta, Thoracic/diagnostic imaging/*physiopathology, Blood Flow Velocity/*physiology, Brachial Artery/diagnostic imaging/physiopathology, Carotid Artery, Common/diagnostic imaging/*physiopathology, Echocardiography, Elasticity, Female, Humans, Male, Middle Aged, Observer Variation, Retrospective Studies, Severity of Illness Index, Sleep Apnea, Obstructive/diagnostic imaging/*physiopathology, Tunica Intima/diagnostic imaging, Ultrasonography, Doppler, Vasodilation/*physiology, cardiovascular system, respiratory tract diseases
Abstract

BACKGROUND AND OBJECTIVE: Obstructive sleep apnea (OSA) has a critical association with cardiovascular mortality and morbidity. Carotid intima-media thickness (IMT), flow-mediated dilatation (FMD) and aortic stiffness are early signs of atherosclerosis. The presence of subclinical atherosclerosis was assessed in OSA patients using these parameters. METHODS: 40 patients with OSA showing an apnea-hypopnea index (AHI) > or =5 (mean age 51.3 +/- 9 years, 32 males) and 24 controls (AHI < 5, mean age 51.9 +/- 5.2 years, 19 males) were enrolled in the study. In all subjects, polysomnographic examination and recordings were performed during sleep. IMT of the carotid artery, endothelium-dependent/-independent vasodilation of the brachial artery and aortic elastic parameters were investigated using high-resolution Doppler echocardiography. RESULTS: The demographic data of the patients with OSA and controls were not significantly different. Subjects with OSA demonstrated higher values of aortic stiffness (7.1 +/- 1.88 vs. 6.42 +/- 1.56, respectively) and IMT (0.85 +/- 0.13 vs. 0.63 +/- 0.11 mm, p = 0.0001, respectively) but lower distensibility (9.47 +/- 1.33 vs. 11.8 +/- 3.36 cm(2)/dyn/10(6)) and FMD (4.57 +/- 1.3 vs. 6.34 +/- 0.83%, p = 0.0001, respectively) than the controls. The respiratory disturbance index correlated positively with aortic stiffness and IMT and negatively with distensibility and FMD. CONCLUSION: We observed blunted endothelium-dependent dilatation, increased carotid IMT and aortic stiffness in patients with OSA compared with matched control subjects. This is evident in the absence of other diseases, suggesting that OSA is an independent cause of atherosclerosis. These simple and non-invasive methods help to detect subclinical atherosclerosis in OSA.

Published
2006

45. study in rats

Author

Ozkurt, S, Herek, O, Atalay, H, Kaleli, I, and Kara, CO

Subjects
bacterial translocation, bronchoscopy, hypoxemia
Abstract

Background: Although some reports suggest that bronchoscopy induces bacterial translocation (BT), the mechanisms of BT remain unclear. Objective: We aimed to assess whether bronchoscopy or hypoxemia during bronchoscopy is responsible for BT. Methods: We evaluated 24 rats divided into three subgroups: the control group ( group 1, n = 8); the rigid bronchoscopy group ( group 2, n = 8), and the group receiving bronchoscopy + mechanical ventilation ( group 3, n = 8). Oxygen saturation (SaO(2)) was measured during the bronchoscopic procedure. Blood and tissue cultures from mesenteric lymph nodes (MLNs), liver, spleen and cecal contents were obtained 24 h following bronchoscopy. Results: In group 2, SaO2 was significantly lower than in groups 1 and 3 ( p < 0.01). In group 2, BT significantly increased (6/8, 75%; p < 0.01 vs. group 1, and p < 0.05 vs. group 3). The main site of translocation was MLNs ( 6/ 8, 75%) in group 2, while BT was detected in only 1 rat in group 3 (1/8, 12.5%). Conclusion: Hypoxemia during rigid bronchoscopy resulted in intestinal mucosal damage in a rat model. Hypoxemia may have been the trigger for BT from the intestine following bronchoscopy. Copyright (C) 2005 S. Karger AG, Basel. C1 Pamukkale Univ Sch Med, Dept Chest Dis, TR-20100 Denizli, Turkey. Pamukkale Univ Sch Med, Dept Pediat Surg, TR-20100 Denizli, Turkey. Pamukkale Univ Sch Med, Dept Anesthesiol & Reanimat, TR-20100 Denizli, Turkey. Pamukkale Univ Sch Med, Dept Microbiol, TR-20100 Denizli, Turkey. Pamukkale Univ Sch Med, Dept Otorhinolaryngol, TR-20100 Denizli, Turkey.

Published
2005

46. Impaired sympathetic skin response in chronic obstructive pulmonary

Author

Bir, LS, Ozkurt, S, Daloglu, G, and Kurt, T

Subjects
chronic obstructive pulmonary disease, sympathetic skin response, food and beverages, respiratory tract diseases, autonomic nervous system, dysautonomia, electromyography
Abstract

The sympathetic skin response (SSR) is considered as one of the indexes of autonomic nervous system functions, especially related with the sudomotor function of unmyelinated sympathetic fibers. SSRs are recorded as the potentials with biphasic or multiphasic waveforms by conventional electromyography. SSRs are evaluated by measuring latency (time from the stimulus to the onset), amplitude, and area (the space under the curve of the waveform). Although dysautonomia is a feature of chronic obstructive pulmonary disease (COPD), as demonstrated by acetylcholine sweat-spot test, there are no data concerning SSR in COPD patients. In this study, we electrophysiologically investigated the sudomotor function of the sympathetic nervous system in patients with COPD. SSRs were recorded in 30 patients with COPD and 21 healthy volunteers. Normal responses were obtained from all subjects in the control group. No response was observed in three patients with COPD. The mean latency, amplitude and area values of the potentials recorded of the remaining 27 patients were compared to the control. The mean latency was longer (p < 0.01) and the mean amplitude and area values were lower (p < 0.012, p = 0.021, respectively) in the patients compared to the control. We also demonstrated significant correlations between the latency, amplitude, or area values of the SSR and two parameters of pulmonary function tests forced expiratory Volume one second/forced vital capacity (FEV1/FVC) and FEV1/FVC %. In conclusion, SSR is impaired in patients with COPD, which indicates the dysfunction of the sympathetic nervous System. Furthermore, the degree of impairment in SSR may reflect the severity of airway obstruction in patients with COPD.

Published
2005

47. QT interval dispersion in obstructive sleep apnoea syndrome patients

Author

Dursunoglu, D, Dursunoglu, N, Evrengul, H, Ozkurt, S, Kilic, M, Fisekci, F, Kuru, O, and Delen, O

Subjects
stomatognathic system, obstructive sleep apnoea syndrome, QT interval dispersion, nervous system diseases, respiratory tract diseases
Abstract

QT interval dispersion (QTd) reflects inhomogeneity of repolarisation. Delayed cardiac repolarisation leading to the prolongation of the QT interval is a well-characterised precursor of arrhythmias. Obstructive sleep apnoea syndrome (OSAS) can cause cardiovascular complications, such as arrhythmias, myocardial infarction, and systemic and pulmonary hypertension. The aim of this study was to assess QTd in OSAS patients without hypertension. A total of 49 subjects without hypertension, diabetes mellitus, any cardiac or pulmonary diseases, or any hormonal, hepatic, renal or electrolyte disorders were referred for evaluation of OSAS. An overnight polysomnography and a standard 12-lead ECG were performed in each subject. According to the apnoea-hypopnoea index (AHI), subjects were divided into control subjects (AHI < 5, n = 20) and moderate-severe OSAS patients (AHI >= 15, n = 29). QTd (defined as the difference between the maximum and minimum QT interval) and QT-corrected interval dispersion (QTcd) were calculated using Bazzet's formula. In conclusion, the QTcd was significantly higher in OSAS patients (56.1 +/- 9.3 ms) than in controls (36.3 +/- 4.5 ms). A strong positive correlation was shown between QTCd and AHI. In addition, a significantly positive correlation was shown between QTCd and the desaturation index (DI). The AHI and DI were significantly related to QTCd as an independent variable using stepwise regression analysis. The QT-corrected interval dispersion is increased in obstructive sleep apnoea syndrome patients without hypertension, and it may reflect obstructive sleep apnoea syndrome severity. C1 Pamukkale Univ, Fac Med, Dept Cardiol, Denizli, Turkey. Pamukkale Univ, Fac Med, Dept Chest Dis, Denizli, Turkey.

Published
2005

48. Impact of obstructive sleep apnoea on left ventricular mass and global

Author

Dursunoglu, D, Dursunoglu, N, Evrengul, H, Ozkurt, S, Kuru, O, Kilic, M, and Fisekci, F

Subjects
stomatognathic system, apnoea syndrome, left ventricular mass, myocardial performance index, obstructive sleep, nervous system diseases, respiratory tract diseases
Abstract

Obstructive sleep apnoea syndrome (OSAS) might be a cause of heart failure. The present study aimed to assess left ventricular mass and myocardial performance index (MPI) in OSAS patients. A total of 67 subjects without any cardiac or pulmonary disease, referred for evaluation of OSAS, had overnight polysomnography and echocardiography. According to apnoea-hypopnoea index (AHI), subjects were classified into three groups: mild OSAS (AHI: 5-14; n=16), moderate OSAS (AHI: 15-29; n=18), and severe OSAS (AHI: >= 30; n=33). Thickness of interventricular septum (IVS) and posterior wall (LVPW) were measured by M-mode, along with left ventricular mass (LVM) and LVM index (LVMI). Left ventricular MPI was calculated as (isovolumic contraction time+isovolumic relaxation time)/aortic ejection time by Doppler echocardiography. There were no differences in age or body mass index among the groups, but blood pressures were higher in severe OSAS compared with moderate and mild OSAS. In severe OSAS, thickness of IVS (11.2 +/- 1.1 mm), LVPW (11.4 +/- 0.9 mm), LVM (298.8 +/- 83.1 g) and LVMI (144.7 +/- 39.8 g.m(-2)) were higher than in moderate OSAS (10.9 +/- 1.3 mm; 10.8 +/- 0.9 mm; 287.3 +/- 74.6 g; 126.5 +/- 41.2 g.m(-2), respectively) and mild OSAS (9.9 +/- 0.9 mm; 9.8 +/- 0.8 mm; 225.6 +/- 84.3 g; 100.5 +/- 42.3 g.m(-2), respectively). In severe OSAS, MPI (0.64 +/- 0.14) was significantly higher than in mild OSAS (0.50 +/- 0.09), but not significantly higher than moderate OSAS (0.60 +/- 0.10). In conclusion, severe and moderate obstructive sleep apnoea syndrome patients had higher left ventricular mass and left ventricular mass index, and also left ventricular global dysfunction. C1 Pamukkale Univ, Fac Med, Dept Cardiol, Denizli, Turkey. Pamukkale Univ, Fac Med, Dept Chest Dis, Denizli, Turkey.

Published
2005

49. Impaired sympathetic skin response in chronic obstructive pulmonary disease

Author

Bir LS, Ozkurt S, Daloğlu G, and Kurt T

Subjects
Electrophysiology, Female, Humans, Male, Middle Aged, Pulmonary Disease, Chronic Obstructive/*physiopathology, Skin/*physiopathology, food and beverages, respiratory tract diseases
Abstract

The sympathetic skin response (SSR) is considered as one of the indexes of autonomic nervous system functions, especially related with the sudomotor function of unmyelinated sympathetic fibers. SSRs are recorded as the potentials with biphasic or multiphasic waveforms by conventional electromyography. SSRs are evaluated by measuring latency (time from the stimulus to the onset), amplitude, and area (the space under the curve of the waveform). Although dysautonomia is a feature of chronic obstructive pulmonary disease (COPD), as demonstrated by acetylcholine sweat-spot test, there are no data concerning SSR in COPD patients. In this study, we electrophysiologically investigated the sudomotor function of the sympathetic nervous system in patients with COPD. SSRs were recorded in 30 patients with COPD and 21 healthy volunteers. Normal responses were obtained from all subjects in the control group. No response was observed in three patients with COPD. The mean latency, amplitude and area values of the potentials recorded of the remaining 27 patients were compared to the control. The mean latency was longer (p

Published
2005

50. Does rigid bronchoscopy induce bacterial translocation? An experimental study in rats

Author

Ozkurt S, Herek O, Atalay H, Kaleli I, and Kara CO

Subjects
Bacteria, Colony Count, Microbial, Bacterial Infections, Rats, Disease Models, Animal, Liver, Animals, Bacteria/*growth & development/isolation & purification, Bacterial Infections/blood/*etiology/microbiology, Bacterial Translocation/*physiology, Bronchoscopy/*adverse effects/methods, Liver/microbiology, Lymph Nodes/microbiology, Mesentery, Rats, Wistar, Spleen/microbiology, Bacterial Translocation, Bronchoscopy, Lymph Nodes, Spleen
Abstract

BACKGROUND: Although some reports suggest that bronchoscopy induces bacterial translocation (BT), the mechanisms of BT remain unclear. OBJECTIVE: We aimed to assess whether bronchoscopy or hypoxemia during bronchoscopy is responsible for BT. METHODS: We evaluated 24 rats divided into three subgroups: the control group (group 1, n = 8); the rigid bronchoscopy group (group 2, n = 8), and the group receiving bronchoscopy + mechanical ventilation (group 3, n = 8). Oxygen saturation (SaO(2)) was measured during the bronchoscopic procedure. Blood and tissue cultures from mesenteric lymph nodes (MLNs), liver, spleen and cecal contents were obtained 24 h following bronchoscopy. RESULTS: In group 2, SaO(2) was significantly lower than in groups 1 and 3 (p < 0.01). In group 2, BT significantly increased (6/8, 75%; p < 0.01 vs. group 1, and p < 0.05 vs. group 3). The main site of translocation was MLNs (6/8, 75%) in group 2, while BT was detected in only 1 rat in group 3 (1/8, 12.5%). CONCLUSION: Hypoxemia during rigid bronchoscopy resulted in intestinal mucosal damage in a rat model. Hypoxemia may have been the trigger for BT from the intestine following bronchoscopy.

Published
2004

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