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1. Shape evolution in the neutron-rich osmium isotopes: Prompt gamma-ray spectroscopy of Os196

Author

John, P. R., Modamio, V., Valiente-Dobon, J. J., Mengoni, D., Lunardi, S., Rodriguez, T. R., Bazzacco, D., Gadea, A., Wheldon, C., Alexander, T., Angelis, G., Ashwood, N., Barr, M., Benzoni, G., Birkenbach, B., Bizzeti, P. G., Bizzeti-Sona, A. M., Bottoni, S., Bowry, M., Bracco, A., Browne, F., Bunce, M., Camera, F., Cederwall, B., Corradi, L., Crespi, F. C. L., Desesquelles, P., Eberth, J., Farnea, E., Fioretto, E., Goergen, A., Gottardo, A., Grebosz, J., Grente, L., Hess, H., Jungclaus, A., Kokalova, Tz, Korichi, A., Wolfram KORTEN, Kusoglu, A., Lenzi, S., Leoni, S., Ljungvall, J., Maron, G., Meczynski, W., Melon, B., Menegazzo, R., Michelagnoli, C., Mijatovic, T., Million, B., Molini, P., Montagnoli, G., Montanari, D., Napoli, D. R., Nolan, P., Oziol, Ch, Podolyak, Zs, Pollarolo, G., Pullia, A., Quintana, B., Recchia, F., Reiter, P., Roberts, O. J., Rosso, D., Sahin, E., Salsac, M. D., Scarlassara, F., Sferrazza, M., Simpson, J., Soderstrom, P. A., Stefanini, A. M., Stezowski, O., Szilner, S., Theisen, Ch, Ur, C. A., and Walshe, J.

Subjects
Nuclear Theory, Nuclear Experiment
Abstract

The shape transition in the neutron-rich Os isotopes is studied by investigating the neutron-rich 196Os nucleus through in-beam γ-ray spectroscopy using a two-proton transfer reaction from a 198Pt target to a 82Se beam. The beam-like recoils were detected and identified with the large-acceptance magnetic spectrometer PRISMA, and the coincident γ rays were measured with the advanced gamma tracking array (AGATA) demonstrator. The de-excitation of the low-lying levels of the yrast-band of 196Os were identified for the first time. The results are compared with state-of-the-art beyond-mean-field calculations, performed for the even-even 188-198Os isotopes. The new results suggest a smooth transition in the Os isotopes from a more axial rotational behavior towards predominately vibrational nuclei through triaxial configurations. An almost perfect γ-unstable/triaxial rotor yrast band is predicted for 196Os which is in agreement with the experimentally measured excited states

Published
2014

2. Shape evolution in the neutron-rich osmium isotopes: Prompt γ-ray spectroscopy of Os196

Author

R. John, P., Modamio, V., Valiente-Dobón, J.J., Mengoni, D., Lunardi, S., R. Rodríguez, T., Bazzacco, D., Gadea, A., Wheldon, C., Alexander, T., De Angelis, G., Ashwood, N., Barr, M., Benzoni, G., Birkenbach, B., G. Bizzeti, P., M. Bizzeti-Sona, A., Bottoni, S., Bowry, M., Bracco, A., Browne, F., Bunce, M., Camera, F., Cederwall, B., Corradi, L., C. L. Crespi, F., Désesquelles, P., Eberth, J., Farnea, E., Fioretto, E., Görgen, A., Gottardo, A., Grebosz, J., Grente, L., Hess, H., Jungclaus, A., Kokalova, Tz., Korichi, A., Korten, W., Kuşoğlu, A., Lenzi, S., Leoni, S., Ljungvall, J., Maron, G., Meczynski, W., Melon, B., Menegazzo, R., Michelagnoli, C., Mijatović, T., Million, B., Molini, P., Montagnoli, G., Montanari, D., R. Napoli, D., Nolan, P., Oziol, Ch., Podolyák, Zs., Pollarolo, G., Pullia, A., Quintana, B., Recchia, F., Reiter, P., J. Roberts, O., Rosso, D., Şahin, E., Salsac, M.-D., Scarlassara, F., Sferrazza, M., Simpson, J., Söderström, P.-A., M. Stefanini, A., Stezowski, O., Szilner, S., Theisen, Ch., Ur, C.A., Walshe, J., CSNSM SNO, Centre de Spectrométrie Nucléaire et de Spectrométrie de Masse (CSNSM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)-Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de Physique Nucléaire d'Orsay (IPNO), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
Nuclear Theory, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Nuclear Experiment
Abstract

The shape transition in the neutron-rich Os isotopes is studied by investigating the neutron-rich 196Os nucleus through in-beam γ-ray spectroscopy using a two-proton transfer reaction from a 198Pt target to a 82Se beam. The beam-like recoils were detected and identified with the large-acceptance magnetic spectrometer PRISMA, and the coincident γ rays were measured with the advanced gamma tracking array (AGATA) demonstrator. The de-excitation of the low-lying levels of the yrast-band of 196Os were identified for the first time. The results are compared with state-of-the-art beyond-mean-field calculations, performed for the even-even 188−198Os isotopes. The new results suggest a smooth transition in the Os isotopes from a more axial rotational behavior towards predominately vibrational nuclei through triaxial configurations. An almost perfect γ-unstable/triaxial rotor yrast band is predicted for 196Os which is in agreement with the experimentally measured excited states.

Published
2014
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3. Shape evolution in the neutron-rich Osmium isotopes: prompt gamma-ray spectroscopy of 196Os

Author

John, P.R., Modamio, V., Valiente-Dobon, J.J., Mengoni, D., Lunardi, S., Rodriguez, T.R., Bazzacco, D., Gadea, A., Wheldon, C., Alexander, T., de Angelis, G., Ashwood, N., Barr, M., Benzoni, G., Birkenbach, B., Bizzeti, P.G., Bizzeti-Sona, A.M., Bottoni, S., Bowry, M., Bracco, A., Browne, F., Bunce, M., Camera, F., Cederwall, B., Corradi, L., Crespi, F.C.L., Desesquelles, P., Eberth, J., Farnea, E., Fioretto, E., Gorgen, A., Gottardo, A., Grebosz, J., Grente, L., Hess, H., Jungclaus, A., Kokalova, Tz., Korichi, A., Korten, W., Kusoglu, A., Lenzi, S., Leoni, S., Ljungvall, J., Maron, G., Meczynski, W., Menegazzo, R., Michelagnoli, C., Mijatovic, Tea, Million, B., Molini, P., Montagnoli, G., Montanari, D., Napoli, D.R., Nolan, P., Oziol, Ch., Podolyak, Zs., Pollarolo, G., Pullia, A., Quintana, B., Recchia, F., Reiter, P., Roberts, O.J., Rosso, D., Sahin, E., Salsac, M.-D., Scarlassara, F., Sferrazza, M., Simpson, J., Soderstrom, P.-A., Stefanini, A.M., Stezowski, O., Szilner, Suzana, Theisen, Ch., Ur, C.A., and Walshe, J.

Subjects
Nuclear Theory, shape transition, neutron rich nuclei, gamma-ray spectroscopy, Nuclear Experiment
Abstract

The shape transition in the neutron-rich Os isotopes is studied by investigating the neutron rich 196Os nucleus through in-beam gamma-ray spectroscopy using a two-proton transfer reaction from a 198Pt target to a 82Se beam. The beam-like recoils were detected and identified with the large-acceptance magnetic spectrometer PRISMA and the coincident gamma rays were measured with the AGATA demonstrator. The de-excitation of the low-lying levels of the yrast-band of 196Os were identified for the first time. The results are compared with state-of-the-art beyond mean-field calculations, performed for the even-even 188, 198Os isotopes. The new results suggest a smooth transition in the Os isotopes from a more axial rotational behaviour towards predominately vibrational nuclei through triaxial configurations. An almost perfect gamma-unstable/triaxial rotor yrast-band is predicted for 196Os which is in agreement with the experimentally measured excited states.

Published
2014
Full Text
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4. Shape evolution in the neutron-rich osmium isotopes: Prompt γ-ray spectroscopy of Os 196

Author

John, Philipp Rudolf, Modamio, V, Valiente-Dobon, J.J., Mengoni, D, Lunardi, S., Rodriguez, T.R., Bazzacco, D., Gadea, A, Wheldon, C, Alexander, T, De Angelis, G., Ashwood, N., Barr, M, Benzoni, Giovanna, Birkenbach, B, Bizzetti, PG, Bizzetti-Sona, AM, Bottoni, S., Bowry, M, Bracco, Angela, Browne, F, Bunce, M, Camera, F., Cederwall, B, Corradi, Lorenzo, Crespi, Fabio Celso Luigi, Désesquelles, Pierre, Eberth, J, Farnea, E., Fioretto, E., Görgen, Andreas, Gottardo, A, Grebosz, J, Grente, L, Hess, H, Jungclaus, A, Kokalova, Tz, Korichi, Ahmed, Korten, W., Kusoglu, A, Lenzi, S.M., Leoni, S., Ljungvall, J, Maron, G., Meczynski, W, Melon, Barbara, Menegazzo, R., Michelagnoli, C, Mijatovic, T., Million, B., Molini, P, Montagnoli, G., Montanari, D, Napoli, D, Nolan, P M, Oziol, Ch., Podolyak, Zs., Pollarolo, G, Pullia, Alberto, Quintana, B., Recchia, F, Reiter, P., Roberts, Oliver O.J., Rosso, D, Sahin, E, Salsac, M-.D, Scarlassara, Fernando, Sferrazza, Michele, Simpson, J., Soderstrom, P.-A., Stefanini, A.M., Stezowski, O, Szilner, Suzana, Theisen, Ch, Ur, C.A., Walshe, J., John, Philipp Rudolf, Modamio, V, Valiente-Dobon, J.J., Mengoni, D, Lunardi, S., Rodriguez, T.R., Bazzacco, D., Gadea, A, Wheldon, C, Alexander, T, De Angelis, G., Ashwood, N., Barr, M, Benzoni, Giovanna, Birkenbach, B, Bizzetti, PG, Bizzetti-Sona, AM, Bottoni, S., Bowry, M, Bracco, Angela, Browne, F, Bunce, M, Camera, F., Cederwall, B, Corradi, Lorenzo, Crespi, Fabio Celso Luigi, Désesquelles, Pierre, Eberth, J, Farnea, E., Fioretto, E., Görgen, Andreas, Gottardo, A, Grebosz, J, Grente, L, Hess, H, Jungclaus, A, Kokalova, Tz, Korichi, Ahmed, Korten, W., Kusoglu, A, Lenzi, S.M., Leoni, S., Ljungvall, J, Maron, G., Meczynski, W, Melon, Barbara, Menegazzo, R., Michelagnoli, C, Mijatovic, T., Million, B., Molini, P, Montagnoli, G., Montanari, D, Napoli, D, Nolan, P M, Oziol, Ch., Podolyak, Zs., Pollarolo, G, Pullia, Alberto, Quintana, B., Recchia, F, Reiter, P., Roberts, Oliver O.J., Rosso, D, Sahin, E, Salsac, M-.D, Scarlassara, Fernando, Sferrazza, Michele, Simpson, J., Soderstrom, P.-A., Stefanini, A.M., Stezowski, O, Szilner, Suzana, Theisen, Ch, Ur, C.A., and Walshe, J.

Abstract

The shape transition in the neutron-rich Os isotopes is studied by investigating the neutron-rich 196Os nucleus through in-beam γ-ray spectroscopy using a two-proton transfer reaction from a 198Pt target to a 82Se beam. The beam-like recoils were detected and identified with the large-acceptance magnetic spectrometer PRISMA, and the coincident γ rays were measured with the advanced gamma tracking array (AGATA) demonstrator. The de-excitation of the low-lying levels of the yrast-band of 196Os were identified for the first time. The results are compared with state-of-the-art beyond-mean-field calculations, performed for the even-even 188-198Os isotopes. The new results suggest a smooth transition in the Os isotopes from a more axial rotational behavior towards predominately vibrational nuclei through triaxial configurations. An almost perfect γ-unstable/triaxial rotor yrast band is predicted for 196Os which is in agreement with the experimentally measured excited states. © 2014 American Physical Society., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2014

5. Shape evolution in the neutron-rich osmium isotopes : Prompt gamma-ray spectroscopy of Os-196

Author

John, P. R., Modamio, V., Valiente-Dobon, J. J., Mengoni, D., Lunardi, S., Rodriguez, T. R., Bazzacco, D., Gadea, A., Wheldon, C., Alexander, T., de Angelis, G., Ashwood, N., Barr, M., Benzoni, G., Birkenbach, B., Bizzeti, P. G., Bizzeti-Sona, A. M., Bottoni, S., Bowry, M., Bracco, A., Browne, F., Bunce, M., Camera, F., Cederwall, B., Corradi, L., Crespi, F. C. L., Desesquelles, P., Eberth, J., Farnea, E., Fioretto, E., Goergen, A., Gottardo, A., Grebosz, J., Grente, L., Hess, H., Jungclaus, A., Kokalova, Tz., Korichi, A., Korten, W., Kusoglu, A., Lenzi, S., Leoni, S., Ljungvall, J., Maron, G., Meczynski, W., Melon, B., Menegazzo, R., Michelagnoli, C., Mijatovic, T., Million, B., Molini, P., Montagnoli, G., Montanari, D., Napoli, D. R., Nolan, P., Oziol, Ch., Podolyak, Zs., Pollarolo, G., Pullia, A., Quintana, B., Recchia, F., Reiter, P., Roberts, O. J., Rosso, D., Sahin, E., Salsac, M. -D, Scarlassara, F., Sferrazza, M., Simpson, J., Söderström, P. -A, Stefanini, A. M., Stezowski, O., Szilner, S., Theisen, Ch., Ur, C. A., Walshe, J., John, P. R., Modamio, V., Valiente-Dobon, J. J., Mengoni, D., Lunardi, S., Rodriguez, T. R., Bazzacco, D., Gadea, A., Wheldon, C., Alexander, T., de Angelis, G., Ashwood, N., Barr, M., Benzoni, G., Birkenbach, B., Bizzeti, P. G., Bizzeti-Sona, A. M., Bottoni, S., Bowry, M., Bracco, A., Browne, F., Bunce, M., Camera, F., Cederwall, B., Corradi, L., Crespi, F. C. L., Desesquelles, P., Eberth, J., Farnea, E., Fioretto, E., Goergen, A., Gottardo, A., Grebosz, J., Grente, L., Hess, H., Jungclaus, A., Kokalova, Tz., Korichi, A., Korten, W., Kusoglu, A., Lenzi, S., Leoni, S., Ljungvall, J., Maron, G., Meczynski, W., Melon, B., Menegazzo, R., Michelagnoli, C., Mijatovic, T., Million, B., Molini, P., Montagnoli, G., Montanari, D., Napoli, D. R., Nolan, P., Oziol, Ch., Podolyak, Zs., Pollarolo, G., Pullia, A., Quintana, B., Recchia, F., Reiter, P., Roberts, O. J., Rosso, D., Sahin, E., Salsac, M. -D, Scarlassara, F., Sferrazza, M., Simpson, J., Söderström, P. -A, Stefanini, A. M., Stezowski, O., Szilner, S., Theisen, Ch., Ur, C. A., and Walshe, J.

Abstract

The shape transition in the neutron-rich Os isotopes is studied by investigating the neutron-rich Os-196 nucleus through in-beam gamma-ray spectroscopy using a two-proton transfer reaction from a Pt-198 target to a Se-82 beam. The beam-like recoils were detected and identified with the large-acceptance magnetic spectrometer PRISMA, and the coincident gamma rays were measured with the advanced gamma tracking array (AGATA) demonstrator. The de-excitation of the low-lying levels of the yrast-band of Os-196 were identified for the first time. The results are compared with state-of-the-art beyond-mean-field calculations, performed for the even-even Os188-198 isotopes. The new results suggest a smooth transition in the Os isotopes from a more axial rotational behavior towards predominately vibrational nuclei through triaxial configurations. An almost perfect gamma-unstable/triaxial rotor yrast band is predicted for Os-196 which is in agreement with the experimentally measured excited states.

Published
2014
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6. Shape evolution in the neutron-rich osmium isotopes: Promptγ-rayspectroscopy ofOs196

Author

John, P. R., primary, Modamio, V., additional, Valiente-Dobón, J. J., additional, Mengoni, D., additional, Lunardi, S., additional, Rodríguez, T. R., additional, Bazzacco, D., additional, Gadea, A., additional, Wheldon, C., additional, Alexander, T., additional, de Angelis, G., additional, Ashwood, N., additional, Barr, M., additional, Benzoni, G., additional, Birkenbach, B., additional, Bizzeti, P. G., additional, Bizzeti-Sona, A. M., additional, Bottoni, S., additional, Bowry, M., additional, Bracco, A., additional, Browne, F., additional, Bunce, M., additional, Camera, F., additional, Cederwall, B., additional, Corradi, L., additional, Crespi, F. C. L., additional, Désesquelles, P., additional, Eberth, J., additional, Farnea, E., additional, Fioretto, E., additional, Görgen, A., additional, Gottardo, A., additional, Grebosz, J., additional, Grente, L., additional, Hess, H., additional, Jungclaus, A., additional, Kokalova, Tz., additional, Korichi, A., additional, Korten, W., additional, Kuşoğlu, A., additional, Lenzi, S., additional, Leoni, S., additional, Ljungvall, J., additional, Maron, G., additional, Meczynski, W., additional, Melon, B., additional, Menegazzo, R., additional, Michelagnoli, C., additional, Mijatović, T., additional, Million, B., additional, Molini, P., additional, Montagnoli, G., additional, Montanari, D., additional, Napoli, D. R., additional, Nolan, P., additional, Oziol, Ch., additional, Podolyák, Zs., additional, Pollarolo, G., additional, Pullia, A., additional, Quintana, B., additional, Recchia, F., additional, Reiter, P., additional, Roberts, O. J., additional, Rosso, D., additional, Şahin, E., additional, Salsac, M.-D., additional, Scarlassara, F., additional, Sferrazza, M., additional, Simpson, J., additional, Söderström, P.-A., additional, Stefanini, A. M., additional, Stezowski, O., additional, Szilner, S., additional, Theisen, Ch., additional, Ur, C. A., additional, and Walshe, J., additional

Published
2014
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7. Nasopharyngeal and serological anti SARS-CoV-2 IgG/IgA responses in COVID-19 patients

Author

Sylvie van der Werf, Caroline Demeret, Bernadette Crescenzo-Chaigne, Lila Bouadma, Jade Ghosn, Vincent Enouf, Sarah Tubiana, Stéphane Petres, Marie Noelle Ungeheuer, Sylvie Behillil, Nicolas Escriou, Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPC), Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] (CNR), Institut Pasteur [Paris], Plateforme de Microbiologie Mutualisée (PIBnet) - Mutualized Platform for Microbiology (P2M), Laboratoire d’innovation : vaccins – Innovation lab : vaccines, Plateforme technologique Production et purification de protéines recombinantes – Production and Purification of Recombinant Proteins Technological Platform (PPR), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Investigation Clinique et d’Accès aux Ressources Biologiques (Plate-forme) - Clinical Investigation and Access to BioResources (ICAReB), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC)-Université Sorbonne Paris Nord, Services de Maladies Infectieuses et Tropicales [CHU Bichat], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre d'Investigations Cliniques [CHU Bichat] (CIC plurithématique), This work was supported by the « URGENCE COVID-19 » fundraising campaign of Institut Pasteur, by REACTING (Research & Action Emerging Infectious Diseases) and by the H2020 project 101003589 (RECOVER). The French Covid Cohort is funded through the Ministry of Health and Social Affairs (PHRC n°20-0424) and Ministry of Higher Education and Research dedicated COVID19 fund., List of the membership of the French COVID cohort study group : Mélanie RORIZ, Patrick RISPAL, Sarah REDL (CHG d'Agen), Laurent LEFEBVRE, Pascal GRANIER, Laurence MAULIN (CH du Pays d'Aix, Aix en Provence), Cédric JOSEPH, Julien MOYET, Sylvie LION-DAOLIO (CHU Amiens Nord), Rafael MAHIEU, Alexandra DU-CANCELLE, Vincent DUBEE (CHU d'Angers), Stéphane SALLA-BERRY, Aldric MANUEL, Gabriel MACHEDA, Mylène MAILLET, Bruno CHANZY (CH d'Annecy Genevois), Jean-Charles GAGNARD (Hôpital privé d'Antony), Guillermo GIORDANO, Clara MOUTON PERROT, Vincent PESTRE (CH Henri Duffaut, Avignon), Cécile FICKO, Marie GOMINET, Aurore BOUSQUET (Hôpital d'instruction des armées Begin), Charline VAUCHY, Kévin BOUILLER, Maïder PAGADOY, Solène MARTY-QUINTERNET, Quentin LEPILLER (CHU Jean Minjoz, Besançon), Cyril LE BRIS, Benoit THILL, Marie-Laure CASANOVA, Georges LE FALHER, Eric OZIOL (CH de Béziers), Hugues CORDEL, Nathalie DOURNON, Olivier BOUCHAUD, Ségolène BRICHLER (Hôpital Avicenne, Bobigny), Duc NGUYEN, Pantxika BELLECAVE, Camille CICCONE, Marie-Edith LAFON (CHU Pellegrin, Bordeaux), Ségolène GREFFE (CHU Ambroise Paré, Boulogne Billancourt), Camille BOUISSE, Nicholas SEDILLOT, Damien BOUHOUR (CH Fleyriat, Bourg en Bresse), Camille CHASSIN (CH Pierre Oudot, Bourgoin-Jallieu), Erwan L'HER, Séverine ANSART, Cécile TROMEUR, Dewi GUELLEC (CHRU de Brest), Antoine MERCKX (CH de Cahors), Felix DJOSSOU (CH Andrée Rosemon, Cayenne), Vincent PEIGNE, Carola PIEROBON, Marie-Christine CARRET, Florence JEGO, Margaux ISNARD (CHMS Chambéry NH), Johann AUCHABIE, Roxane COURTOIS (CH de Cholet), Olivier LESENS (CHU Gabriel Montpied, Clermont-Ferrand), Martin MARTINOT (Hôpital Pasteur, Colmar), Olivier PICONE (Hôpital Louis Mourier, Colombes), Marie LACOSTE (CH Alpes Leman Contamine sur Arve), Brigitte ELHAR-RAR, Valérie GARRAIT, Isabelle DELACROIX, Thomas MAITRE, Jean Baptiste ASSIE (Centre Hospitalier Intercommunal de Créteil), Elsa NYAMANKOLLY (CH de Dax), François Xavier CATHERINE, Ma-thieu BLOT, Sophie MAHY, Marielle BUISSON, Lionel PIROTH, Florence GUILLOTIN, Alexis DE ROUGEMONT (CHU de Dijon Bourgogne), Valentine CAMPANA, Jérémie PASQUIER, André CABIE (CHU de Martinique, Fort de France), Simon BESSIS (Hôpital Raymond Poincaré, Garches), Olivier EPAULARD, Nicolas TERZI, Jean-François PAYEN, Laurence BOUILLET, Rebecca HAMIDFAR, Marion Le MARECHAL (CHU de Grenoble), Moïse MACHADO, Audrey BARRELET, Alexandra BEDOSSA (Grand Hôpital de l'Est Francilien site Marne-la-Vallée, Jossigny), Gwenhaël COLIN, Romain DECOURS, Thomas GUIMARD (CHD Les Oudairies, La Roche Sur Yon), Cécile GOUJARD, Stéphane JAUREGUIBERRY, Antoine CHERET (Hôpital Universitaire Bicêtre, Le Kremlin-Bicêtre), Anne Sophie RESSEGUIER (CH Emile Roux, Le Puy en Velay), Julien POISSY, Daniel MATHIEU, Saad NSEIR, Ilka ENGELMANN, Martine REMY (CHRU de Lille, Hôpital Salengro), Fanny VUOTTO, Benoit GACHET, Karine FAURE, Marielle BOYER-BESSEYRE, Kazali Enagnon (CHRU de Lille, Hôpital Fourrier), Marc LAMBERT, Arnaud SCHERPEREEL, Dominique DEPLANQUE, Stéphanie FRY, Cécile YELNIK (CHRU de Lille, Hôpital Albert Calmette), Laurent BITKER, Mehdi MEZIDI, Hodane YONIS, Nicolas BENECH, Thomas PERPOINT, Anne CONRAD, Vinca ICARD, Martine VALETTE (Hôpital de la Croix Rousse, Lyon), Simon-Djamel THIBERVILLE (Hôpital Louis Raffalli, Manosque), Stanislas REBAUDET (Hôpital Européen de Marseille), Bertrand DUSSOL (Hôpital Conception, Marseille), Sylvain DIAMANTIS, Catherine CHAKVEATZE, Clara FLATEAU (Groupe Hospitalier Sud Ile De France, hôpital de Melun), Vincent DINOT, Rostane GACI, Nadia OUAMARA (Hôpital de Mercy, CHR Metz-Thionville, Ars laquenexy), Hajnal-Gabriela ILLES, Louis GER-BAUD MORLAES, Jérôme DIMET (CH de Mont Marsan), Vincent LE MOING, Nathalie PANSU, Clément LE BIHAN, Brigitte MONTES (CHU de Montpellier), Anne Sophie BOUREAU, Clotilde ALLAVENA, Sabelline BOUCHEZ, Romain GUERY, Paul LE TURNIER, Cécile MEAR-PASSARD, Virginie FERRE (CHU de Nantes), Christophe RAPP (Hôpital Américain de Paris, Neuilly sur Seine), Elisa DE-MONCHY, Céline MICHELANGELLI, Karine RISSO (CHU de Nice), Paul LOUBET, Jean-Phillippe LAVIGNE (CHU Caremeau, Nîmes), Etienne DE MONTMOLLIN, Juliette PATRIER, Paul Henri WICKY, Lucie LE FEVRE, Pierre JACQUET, Raphael BORIE, Antoine DOSSIER, Dominique LUTON, Valentina ISERNIA, Sylvie LE GAC (Hôpital Bichat, Paris), Cécile AZOULAY, Nicolas CARLIER, Liem LUONG, Marie LACHATRE, Odile LAUNAY (Hôpital Cochin, Paris), Younes KERROUMI, Vanina MEYSSONNIER (Groupe Hospitalier Diaconesses Croix Saint-Simon, Paris), Jean-Luc DIEHL, Jean-Sébastien HULOT, Bernard CHOLLEY, Jean-Benoît ARLET, Olivier SANCHEZ (Hôpital Européen Georges Pompidou, Paris), Victoria MANDA, Laurène AZEMAR, Guylaine CASTOR-ALEXANDRE (Hôpital Lariboisière, Paris), Karine LACOMBE, Thibault CHIARABINI, Bénédicte LEFEBVRE, Laurence MORAND-JOUBERT, Djeneba FOFANA, Aurélie SCHNURIGER (Hôpital Saint Antoine, Paris), Nathalie DE CASTRO, Constance DELAUGERRE, Marie-Laure CHAIX (Hôpital Saint Louis, Paris), Julie CHAS (Hôpital Tenon, Paris), Valérie GABORIEAU, Eve LE COUSTUMIER, Walter PICARD (CH de Pau), Jean-Benoît ZABBE, Florent PEELMAN, Edouard SOUM (CH de Périgueux), Hugues AUMAÎTRE (CH de Perpignan), Elodie CURLIER, Rachida OUISSA, Isabelle FABRE (CHU de Pointe à Pitre, Guadeloupe), Blandine RAMMAERT (CHU de Poitiers), Nadia SAIDANI (CH Quimper), Firouzé BANI-SADR, Maxime HENTZIEN, Yohan N 'GUYEN, Juliette ROMARU, Kévin DIDIER (CHU Reims), Isabelle ENDERLE, Vincent THIBAULT, Fabrice LAINE, Matthieu LESOU-HAITIER, Matthieu REVEST, Pierre TATTEVIN (CHU Rennes), Jean-Christophe PLANTIER, Manuel ETIENNE, Véronique LEMEE, Eglantine FERRAND DEVOUGE, Kévin ALEXANDRE, Elise ARTAUD-MACCARI (CHU Rouen), Nathalie ALLOU, Marie LAGRANGE, Julien JABOT (CH Saint Denis et Saint Pierre, La réunion), Benoît ROZE, Delphine BREGEAUD, Younes AIT TAMLIHAT (CH Saintes), Ali HACHEMI (CH Soisson), Hélène SALVATOR, Erwan FOURN, David ZUCMAN (Hôpital Foch, Suresnes), Eric DELAVEUVE, Coline JAUD-FISCHER, Paul DUNAND (Hôpital Bel Air, Thionville), François BISSUEL (CH Thonon les Bains), Karen DELAVIGNE, Marie PIEL-JULIAN, Pierre DELOBEL, Benjamine SARTON, Marie RAFIQ, Guillaume MARTIN-BLONDEL, Laurent GUILLEMINAULT, Marlène MURRIS, Agnès SOMMET (CHU de Toulouse), Eric SENNEVILLE, Olivier ROBINEAU, Agnès MEYBECK (CH Tourcoing), Denis GAROT, Laurent PLANTIER, Valérie GISSOT, Julien MARLET, Karl STEFIC, Catherine GAUDY-GRAFFIN, Francis BARIN, Adrien LEMAIGNEN (CHU Bretonneau, Tours), Grégory CORVAISIER, Delphine LARIVIERE, Marie LANGELOT-RICHARD (CH Vannes), Elisabeth BOTELHO-NEVERS , Amandine GAGNEUX-BRUNON, Tiffany TROUILLON, Thomas BOURLET, Thomas BOURLET, Sylvie PILLET, Bruno POZZETTO (CHU de St Etienne), Antoine KIMMOUM, Bruno LEVY, Mathieu MATTEI, François GOEHRINGER, Christian RABAUD, Sibylle BEVILACQUA, Benjamin LEFEVRE, Anne GUILLAUMOT, Véronique VENARD, Hélène JEULIN, Evelyne SCHVOERER, Cédric HARTARD (CHU de Nancy, Vandoeuvre les Nancy), Pauline CARAUX PAZ, Laurent RICHIER, Mohamed EL SANHARAWI (CH Villeneuve St Georges)., European Project: 101003589, H2020-SC1-PHE-CORONAVIRUS-2020,RECOVER(2020), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] (CNR - laboratoire coordonnateur), Institut Pasteur [Paris] (IP), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord

Subjects
Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), [SDV]Life Sciences [q-bio], Severe disease, Infectious and parasitic diseases, RC109-216, Article, Serology, 03 medical and health sciences, 0302 clinical medicine, Medicine, Mucosal Immunity, 030304 developmental biology, 0303 health sciences, biology, 030306 microbiology, business.industry, Epithelium, 3. Good health, Nucleoprotein, medicine.anatomical_structure, Antibody response, SARS CoV, 030220 oncology & carcinogenesis, Immunology, biology.protein, Antibody, business
Abstract

BackgroundThe systemic antibody responses to SARS-CoV-2 in COVID-19 patients has been extensively studied. However, much less is known about the mucosal responses in the upper airways at the site of initial SARS-CoV-2 replication. Local antibody responses in the nasopharyngeal epithelium, that are likely to determine the course of infection, have not been analysed so far nor their correlation with antibody responses in serum.MethodsThe IgG and IgA antibody responses were analysed in the plasma as well as in nasopharyngeal swabs (NPS) from the first four COVID-19 patients confirmed by RT-qPCR in France. Two were pauci-symptomatic while two developed severe disease. Taking advantage of a comprehensive series of plasma and nasopharyngeal samples, we characterized their antibody profiles from the second week post symptoms onset, by using an in-house ELISA to detect anti-SARS-CoV-2 Nucleoprotein (N) IgG and IgA.ResultsAnti-N IgG and IgA antibodies were detected in the NPS of severe patients. Overall, the levels of IgA and IgG antibodies in plasma and NPS appeared specific to each patient.ConclusionsAnti-N IgG and IgA antibodies are detected in NPS, and their levels are related to antibody levels in plasma. The two patients with severe disease exhibited different antibody profiles that may reflect different disease outcome. For the pauci-symptomatic patients, one showed a low anti-N IgG and IgA response in the plasma only, while the other one did not exhibit overt serological response.

Published
2021
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