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14 results on '"Ozdemir, John"'

2. A Bioconjugated Chlorin-Based Metal–Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers

Author

Sakamaki, Yoshie, primary, Ozdemir, John, additional, Heidrick, Zachary, additional, Azzun, Anthony, additional, Watson, Olivia, additional, Tsuji, Miu, additional, Salmon, Christopher, additional, Sinha, Arvind, additional, Batta-Mpouma, Joseph, additional, McConnell, Zachary, additional, Fugitt, David, additional, Du, Yuchun, additional, Kim, Jin-Woo, additional, and Beyzavi, Hudson, additional

Published
2021
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5. Maltotriose Conjugated Metal–Organic Frameworks for Selective Targeting and Photodynamic Therapy of Triple Negative Breast Cancer Cells and Tumor Associated Macrophages

Author

Sakamaki, Yoshie, primary, Ozdemir, John, additional, Diaz Perez, Alda, additional, Heidrick, Zachary, additional, Watson, Olivia, additional, Tsuji, Miu, additional, Salmon, Christopher, additional, Batta‐Mpouma, Joseph, additional, Azzun, Anthony, additional, Lomonte, Valerie, additional, Du, Yuchun, additional, Stenken, Julie, additional, Kim, Jin‐Woo, additional, and Beyzavi, M. Hassan, additional

Published
2020
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9. Green and Facile Synthesis of Highly Photoluminescent Multicolor Carbon Nanocrystals for Cancer Therapy and Imaging

Author

Abbasi Kajani, Abolghasem, primary, Bordbar, Abdol-Khalegh, additional, Mehrgardi, Masoud Ayatollahi, additional, Zarkesh-Esfahani, Sayyed Hamid, additional, Motaghi, Hasan, additional, Kardi, Mohammad, additional, Khosropour, Ahmad Reza, additional, Ozdemir, John, additional, Benamara, Mourad, additional, and Beyzavi, Hudson, additional

Published
2018
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13. Fabrication of MOF Films of UiO or PCN Type Through Layer-by-Layer Molecular Deposition as well as Bulk Deposition for Catalytic Applications

Author

Ozdemir, John

Subjects
CO2 Fixation, Metal Organic Frameworks, Tandem Catalysis, Thin Films, Materials Chemistry, Organic Chemistry
Abstract

Metal-organic frameworks (MOFs) are crystalline, porous materials comprised of symmetric organic linkers coordinated to positively charged metal atoms or metal oxide nodes. This dissertation uses strategies in crystal engineering to advance the study of functional MOFs with emphasis on thin film deposition. The first chapter of this dissertation will introduce the field of reticular chemistry to the reader and describe synthetic efforts to develop useful building blocks for MOF materials: namely porphyrin macrocycles and carboxylate capped zirconium-oxo and hafnium-oxo clusters. The building blocks for MOFs developed in the first chapter will be employed in the second and third chapters through incorporation into MOF thin films through molecular deposition and bulk deposition respectively. New methods for the molecular deposition of Hf-based MOF films are described which will expand the available MOF types which are known to be deposited in a molecular layer-by-layer fashion. A key methodology is the use of Hf-oxo clusters capped by carboxylate ligands to be used as a potential Hf source for molecular layer-by-layer Hf-MOF deposition. Using an automated epitaxial workstation, films of UiO-66 (Hf) are fabricated for the first time and porphyrinic Hf-based MOFs are developed for catalytic applications. Following these efforts, experiments regarding the bulk-deposition of UiO-66 and UiO-66 (Hf) films are laid out. The UiO-66 (Hf) bulk deposited films are shown to be a promising catalyst for CO2 fixation to epoxides for cyclic carbonate synthesis.

Published
2022

14. A Bio-Conjugated Chlorin-Based Metal-Organic Framework for Targeted Photodynamic Therapy of Triple Negative Breast and Pancreatic Cancers.

Author

Sakamaki Y, Ozdemir J, Heidrick Z, Azzun A, Watson O, Tsuji M, Salmon C, Sinha A, Batta-Mpouma J, McConnell Z, Fugitt D, Du Y, Kim JW, and Beyzavi H

Subjects
Antineoplastic Agents administration & dosage, Antineoplastic Agents therapeutic use, Cell Line, Tumor, Drug Delivery Systems, Humans, Molecular Structure, Nanostructures, Organometallic Compounds chemistry, Pancreatic Neoplasms therapy, Photochemotherapy, Porphyrins chemistry, Triple Negative Breast Neoplasms therapy
Abstract

The field of photodynamic therapy (PDT) has continued to show promise as a potential method for treating tumors. In this work a photosensitizer (PS) has been delivered to cancer cell lines for PDT by incorporation into the metal-organic framework (MOF) as an organic linker. By functionalizing the surface of MOF nanoparticles with maltotriose the PS can efficiently target cancer cells with preferential uptake into pancreatic and breast cancer cell lines. Effective targeting overcomes some current problems with PDT including long-term photosensitivity and tumor specificity. Developing a PS with optimal absorption and stability is one of the foremost challenges in PDT and the synthesis of a chlorin which is activated by long-wavelength light and is resistant to photo-bleaching is described. This chlorin-based MOF shows anti-cancer ability several times higher than that of porphyrin-based MOFs with little toxicity to normal cell lines and no dark toxicity.

Published
2021
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