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3. Respiratory support with nasal high flow without supplemental oxygen in patients undergoing endoscopic retrograde cholangiopancreatography under moderate sedation: a prospective, randomized, single-center clinical trial

Author

Sawase, Hironori, Ozawa, Eisuke, Yano, Hiroshi, Ichinomiya, Taiga, Yano, Rintaro, Miyaaki, Hisamitsu, Komatsu, Naohiro, Ayuse, Takao, Kurata, Shinji, Sato, Shuntaro, Pinkham, Maximilian Ichabod, Tatkov, Stanislav, Ashizawa, Kazuto, Nagata, Kazuyoshi, and Nakao, Kazuhiko

Published
2023
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4. Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2

Author

Murakami, Masatoshi, Fujimori, Nao, Nakata, Kohei, Nakamura, Masafumi, Hashimoto, Shinichi, Kurahara, Hiroshi, Nishihara, Kazuyoshi, Abe, Toshiya, Hashigo, Shunpei, Kugiyama, Naotaka, Ozawa, Eisuke, Okamoto, Kazuhisa, Ishida, Yusuke, Okano, Keiichi, Takaki, Ryo, Shimamatsu, Yutaka, Ito, Tetsuhide, Miki, Masami, Oza, Noriko, Yamaguchi, Daisuke, Yamamoto, Hirofumi, Takedomi, Hironobu, Kawabe, Ken, Akashi, Tetsuro, Miyahara, Koichi, Ohuchida, Jiro, Ogura, Yasuhiro, Nakashima, Yohei, Ueki, Toshiharu, Ishigami, Kousei, Umakoshi, Hironobu, Ueda, Keijiro, Oono, Takamasa, and Ogawa, Yoshihiro

Published
2023
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6. Feasibility and safety of EUS-guided biliary drainage in inexperienced centers: a multicenter study in southwest Japan

Author

Koga, Takehiko, Ishida, Yusuke, Hashigo, Shunpei, Shimokawa, Yuzo, Harima, Hirofumi, Okamoto, Kazuhisa, Ohno, Akihisa, Miyagahara, Tsukasa, Fujita, Toshihiro, Fukuchi, Satoshi, Takahashi, Kosuke, Taguchi, Hiroki, Araki, Norimasa, Ohtsuka, Yuichiro, Uekitani, Toshiyuki, Tsuneyoshi, Kengo, Akiyama, Takumi, Ishigaki, Noriko, Maruo, Toru, Saito, Hirokazu, Ihara, Ryo, Yamasuji, Akihiro, Oe, Shinji, Yoshinari, Motohiro, Sagami, Ryota, Fujimori, Nao, Fukuda, Yoshio, Ozawa, Eisuke, Jikuya, Kenichi, Shinohara, Hiroki, Sen-yo, Manabu, Ueki, Toshiharu, Tsuchiya, Naoaki, Kitaguchi, Takanori, Matsumoto, Keisuke, Fukuyama, Makoto, and Hirai, Fumihito

Published
2024
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9. Total bile acids levels as a stratification tool for screening portopulmonary hypertension in patients with decompensated cirrhosis.

Author

Tajima, Kazuaki, Miuma, Satoshi, Miyaaki, Hisamitsu, Matsuo, Satoshi, Shimakura, Akane, Mori, Tomotaka, Takahashi, Kosuke, Nakao, Yasuhiko, Fukushima, Masanori, Haraguchi, Masafumi, Sasaki, Ryu, Ozawa, Eisuke, and Nakao, Kazuhiko

Subjects
TRICUSPID valve insufficiency, LOGISTIC regression analysis, MULTIPLE regression analysis, URSODEOXYCHOLIC acid, BILE acids
Abstract

Aim: Echocardiography is necessary for portopulmonary hypertension diagnosis, and identifying patients with cirrhosis who require it is challenging. In this study, we aimed to investigate the utility of the total bile acid (TBA) levels as a screening tool for identifying patients with decompensated cirrhosis who should undergo echocardiography for portopulmonary hypertension diagnosis. Methods: We evaluated 135 patients with decompensated cirrhosis who underwent liver transplantation. Subsequently, factors contributing to tricuspid regurgitation pressure gradient (TRPG) elevation (≥30 mmHg) were analyzed using preoperative data, including the TBA levels. Results: The median age of patients was 58 years (61 women), and 45 and 90 patients had Child–Turcotte–Pugh grades of B and C, respectively. The median TRPG level was 21 mmHg, and 17 patients (12.6%) showed TRPG elevation. Multiple logistic regression analysis revealed that elevated TBA (odds ratio 4.322; p = 0.013) and main pulmonary artery diameter ≥33 mm (odds ratio 4.333; p = 0.016) were significantly associated with TRPG elevation. The TBA cut‐off value (167.7 μmol/L) showed a high diagnostic performance, with 70.6% sensitivity and 64.4% specificity. Ursodeoxycholic acid (UDCA) administration increased the TBA levels dose‐dependently. Analysis stratified by UDCA use revealed that in patients not taking UDCA (n = 59), elevated TBA levels and younger age significantly contributed to TRPG elevation. However, in those taking UDCA (n = 76), this contribution disappeared, suggesting that UDCA consumption reduced TBA levels' efficiency in diagnosing TRPG elevation. Conclusions: The TBA levels may be a potential screening tool for TRPG elevation; however, caution is warranted when interpreting cases treated with UDCA. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Fully-Covered Self-Expandable Metal Stent for Hepaticojejunostomy Anastomotic Stricture After Living Donor Liver Transplantation: A Case Series.

Author

Takahashi, Kosuke, Ozawa, Eisuke, Miyaaki, Hisamitsu, Hara, Takanobu, Soyama, Akihiko, Hidaka, Masaaki, Eguchi, Susumu, and Nakao, Kazuhiko

Subjects
*INTRAHEPATIC bile ducts, *LIVER transplantation, *CHOLANGITIS, *MAGNETIC resonance, *JEJUNOSTOMY, *ENDOSCOPY, *CHOLANGIOGRAPHY
Abstract

• We studied 3 cases of HAS after liver transplantation. • HAS may not be resolved with conventional treatment using a plastic stent. • We evaluated the usefulness of fully-covered self-expandable metal stents (FCSEMSs). • FCSEMS placement may be effective and safe for HAS after liver transplantation. • Magnetic resonance cholangiopancreatography should identify HAS before cholangiography. We prospectively evaluated 3 cases regarding the usefulness of fully-covered self-expandable metal stents (FCSEMSs) for hepaticojejunostomy anastomotic stricture (HAS) after living donor liver transplantation (LDLT), which could not be resolved with conventional treatment using a plastic stent. All patients underwent LDLT with Roux-en-Y reconstruction; therefore, a short-type double-balloon enteroscope was used for the endoscopic procedures. HAS was observed on enteroscopic view of endoscopy in patients 1 and 2, and cholangiography revealed dilatation of the intrahepatic bile duct. The FCSEMS was successfully placed without the report of adverse events. The FCSEMS was removed after 16 weeks, and the HAS improved in both patients. In addition, stone clearance was also achieved in patient 2. On the other hand, FCSEMS was not placed in patient 3 because there was no indication of FCSEMS placement due to the multiple segmental biliary strictures (pruned-tree appearance on cholangiography). Subsequent deceased-donor liver transplantation confirmed recurrent primary sclerosing cholangitis. In this case, magnetic resonance cholangiopancreatography (MRCP) was not performed prior to cholangiography to rule out PSC recurrence. FCSEMS placement may be effective and safe for HAS after LDLT, which is not resolved with conventional treatment using a plastic stent. MRCP should be used to identify HAS prior to invasive cholangiography. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Are transmembrane 6 superfamily member 2 gene polymorphisms associated with steatohepatitis after pancreaticoduodenectomy?

Author

Mori, Tomotaka, Ozawa, Eisuke, Sasaki, Ryu, Shimakura, Akane, Takahashi, Kosuke, Kido, Yoko, Kanda, Yasuko, Matsuo, Satoshi, Tajima, Kazuaki, Beppu, Asami, Nakao, Yasuhiko, Fukushima, Masanori, Haraguchi, Masafumi, Miuma, Satoshi, Miyaaki, Hisamitsu, Adachi, Tomohiko, Eguchi, Susumu, Okano, Shinji, and Nakao, Kazuhiko

Subjects
FATTY liver, NON-alcoholic fatty liver disease, GENETIC polymorphisms, PANCREATICODUODENECTOMY, HEPATIC fibrosis
Abstract

Aim: After pancreaticoduodenectomy, 20–40% of patients develop steatotic liver disease (SLD), and steatohepatitis can be a problem. Although patatin‐like phospholipase domain‐containing 3 protein (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2) polymorphisms are involved in SLD and steatohepatitis development, whether this is the case after pancreaticoduodenectomy is unclear. Methods and Results: Forty‐three patients with pancreatic cancer who underwent pancreaticoduodenectomy at our hospital between April 1, 2018, and March 31, 2021, were included. We extracted DNA from noncancerous areas of residual specimens after pancreaticoduodenectomy and determined PNPLA3 and TM6SF2 gene polymorphisms using real‐time polymerase chain reaction. SLD was defined as a liver with an attenuation value of ≤40 HU or a liver‐to‐spleen ratio of ≤0.9 on computed tomography. We defined high hepatic fibrosis indexes (HFI) instead of steatohepatitis as a Fibrosis‐4 index of ≥2.67 or nonalcoholic fatty liver disease fibrosis score of ≥0.675 in patients with SLD. The cumulative incidence of SLD (P = 0.299) and high HFI (P = 0.987) after pancreaticoduodenectomy were not significantly different between the PNPLA3 homozygous and minor allele groups. The incidences of high HFI at 1 year after pancreaticoduodenectomy were 16.8% and 27.0% in the TM6SF2 major homozygous and minor allele groups, respectively, with a significant difference in the cumulative incidence (P = 0.046). Conclusion: The TM6SF2 minor allele may contribute to steatohepatitis development after pancreaticoduodenectomy. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Comparison of a 22-gauge Franseen-tip needle with a 20-gauge forward-bevel needle for the diagnosis of type 1 autoimmune pancreatitis: a prospective, randomized, controlled, multicenter study (COMPAS study)

Author

Kurita, Akira, Yasukawa, Satoru, Zen, Yoh, Yoshimura, Kenichi, Ogura, Takeshi, Ozawa, Eisuke, Okabe, Yoshinobu, Asada, Masanori, Nebiki, Hiroko, Shigekawa, Minoru, Ikeura, Tsukasa, Eguchi, Takaaki, Maruyama, Hirotsugu, Ueki, Toshiharu, Itonaga, Masahiro, Hashimoto, Shinichi, Shiomi, Hideyuki, Minami, Ryuki, Hoki, Noriyuki, Takenaka, Mamoru, Itokawa, Yoshio, Uza, Norimitsu, Hashigo, Shunpei, Yasuda, Hiroaki, Takada, Ryoji, Kamada, Hideki, Kawamoto, Hirofumi, Kawakami, Hiroshi, Moriyama, Ichiro, Fujita, Koichi, Matsumoto, Hisakazu, Hanada, Keiji, Takemura, Tadamasa, and Yazumi, Shujiro

Published
2020
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17. Recent Advances in Endoscopic Ultrasound for Gallbladder Disease Diagnosis.

Author

Takahashi, Kosuke, Ozawa, Eisuke, Shimakura, Akane, Mori, Tomotaka, Miyaaki, Hisamitsu, and Nakao, Kazuhiko

Subjects
*ENDOSCOPIC ultrasonography, *DIAGNOSIS, *CHOLECYSTITIS, *GALLBLADDER, *DRUG discovery, *MACHINE learning
Abstract

Gallbladder (GB) disease is classified into two broad categories: GB wall-thickening and protuberant lesions, which include various lesions, such as adenomyomatosis, cholecystitis, GB polyps, and GB carcinoma. This review summarizes recent advances in the differential diagnosis of GB lesions, focusing primarily on endoscopic ultrasound (EUS) and related technologies. Fundamental B-mode EUS and contrast-enhanced harmonic EUS (CH-EUS) have been reported to be useful for the diagnosis of GB diseases because they can evaluate the thickening of the GB wall and protuberant lesions in detail. We also outline the current status of EUS-guided fine-needle aspiration (EUS-FNA) for GB lesions, as there have been scattered reports on EUS-FNA in recent years. Furthermore, artificial intelligence (AI) technologies, ranging from machine learning to deep learning, have become popular in healthcare for disease diagnosis, drug discovery, drug development, and patient risk identification. In this review, we outline the current status of AI in the diagnosis of GB. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Examination of stabilization of sedation by Nasal High Flow in patients with endoscopic retrograde cholangiopancreatography during sedation using Dexmedetomidine

Author

Ayuse, Takao, Kurata, Shinji, Mori, Tomotaka, Kuroda, Shohei, Ichinomiya, Taiga, Yano, Rintaro, Mishima, Gaku, Ozawa, Eisuke, Tatkov, Stanislav, Sato, Shuntaro, Kazuhiko, Nakao, Hara, Tetsuya, Ayuse, Takao, Kurata, Shinji, Mori, Tomotaka, Kuroda, Shohei, Ichinomiya, Taiga, Yano, Rintaro, Mishima, Gaku, Ozawa, Eisuke, Tatkov, Stanislav, Sato, Shuntaro, Kazuhiko, Nakao, and Hara, Tetsuya

Abstract

Introduction: Dexmedetomidine is used for the sedation method in the case of endoscopic retrograde cholangiopancreatography (ERCP) for the purpose of relieving patient anxiety. It has been reported that CO2 accumulated during sedation causes an arousal reaction, so how to normalize CO2 during sedation can be improved by administration of the minimum necessary sedative. Nasal High Flow oxygen therapy (NHF) uses a mild positive pressure load that improves carbon dioxide washout and reduces rebreathing to improve respiratory function and therefore is widely used to prevent hypoxemia and hypercapnia. In this study, we will investigate whether the upper airway patency would be maintained and the hypercapnia and hypoxemia during sedation would be prevented, by applying NHF as a respiratory management method to patients undergoing ERCP under sedation. Methods/design: In a randomized comparative study of 2 groups, the NHF device use group and the nasal cannula use group, for adult patients who visited the Nagasaki University Hospital and underwent ERCP examination under sedation. For sedation, Dexmedetomidine will be used in combination with and Midazolam and evaluation by anesthesiologist. In addition, as an analgesic, pethidine hydrochloride was administered intravenously. The total dose of the analgesic pethidine hydrochloride used in combination is used as the primary endpoint. As a secondary evaluation item, the percutaneous CO2 concentration is evaluated with a TCO2 monitor to examine whether it is effective in preventing hypercapnia. Furthermore, we will evaluate the incidence of hypoxemia with a percutaneous oxygen saturation value of 90% or less, and examine whether the use of equipment is effective in preventing the occurrence of hypercapnia and hypoxemia. Discussion: The purpose of this study was to obtain evidence for the utility of NHF as a potential therapeutic device for patients undergoing an ERCP under sedation, assessed by determining if the incidence rate, Medicine, 102(23), art. no. e34004; 2023

Published
2023

22. Comparison of the novel Franseen needle versus the fine‐needle aspiration needle in endoscopic ultrasound‐guided tissue acquisition for cancer gene panel testing: A propensity score‐matching analysis.

Author

Mori, Tomotaka, Ozawa, Eisuke, Shimakura, Akane, Takahashi, Kosuke, Matsuo, Satoshi, Tajima, Kazuaki, Nakao, Yasuhiko, Fukushima, Masanori, Sasaki, Ryu, Miuma, Satoshi, Miyaaki, Hisamitsu, Okano, Shinji, and Nakao, Kazuhiko

Subjects
CANCER genes, NEEDLE biopsy, TISSUES, MULTIVARIATE analysis, ODDS ratio
Abstract

Background and Aim: Reports have indicated that a surface area of 4 mm2 or more of collected tissue sections could provide the recommended total DNA for the OncoGuide NCC Oncopanel system, which is a cancer gene panel test developed in Japan. We wished to compare the percentage of tissue sections collected by endoscopic ultrasound‐assisted tissue acquisition (EUS‐TA) with surface areas of ≥4 mm2 between a conventional needle, namely the EZ Shot 3 Plus (Olympus Medical Japan, Tokyo, Japan) (EZ3), and the recent SonoTip TopGain (MediGlobe, Rohrdorf, Germany) (TopGain). Method: From April 2010 to December 2021, among 693 EUS‐TA cases, EZ3 was used in 390 cases and TopGain in 45. The EZ3 and TopGain groups were matched in a 1:1 ratio with a tolerance of 0.2, with 35 patients each matched using propensity score analysis. Results: The TopGain group had a significantly higher percentage of cases with a tissue area of ≥4 mm2 than the EZ3 group (42.9% vs 68.6%, P = 0.030). Multivariate analysis revealed an association between TopGain and tissue areas of ≥4 mm2 (odds ratio 2.996, 95% confidence interval 1.068–8.403, P = 0.037). Conclusions: EUS‐TA using TopGain significantly collected more ≥4 mm2 tissue area compared with EZ3, suggesting its usefulness for cancer gene panel testing. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Respiratory support with nasal high flow without supplemental oxygen in patients undergoing endoscopic retrograde cholangiopancreatography under moderate sedation: a prospective, randomized, single-center clinical trial

Author

Sawase, Hironori, primary, Ozawa, Eisuke, additional, Yano, Hiroshi, additional, Ichinomiya, Taiga, additional, Yano, Rintaro, additional, Miyaaki, Hisamitsu, additional, Komatsu, Naohiro, additional, Ayuse, Takao, additional, Kurata, Shinji, additional, Sato, Shuntaro, additional, Pinkham, Maximilian Ichabod, additional, Tatkov, Stanislav, additional, Ashizawa, Kazuto, additional, Nagata, Kazuyoshi, additional, and Nakao, Kazuhiko, additional

Published
2023
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24. Endoscopic ultrasound-guided fine-needle biopsy of solid pancreatic tumors with 3 versus 12 to-and-fro movements: A multicenter prospective randomized controlled study

Author

Takahashi, Kosuke, primary, Yasuda, Ichiro, additional, Hayashi, Nobuhiko, additional, Iwashita, Takuji, additional, Okuno, Mitsuru, additional, Mukai, Tsuyoshi, additional, Mabuchi, Masatoshi, additional, Adachi, Seiji, additional, Doi, Shinpei, additional, Imura, Johji, additional, Ozawa, Eisuke, additional, Miyaaki, Hisamitsu, additional, and Nakao, Kazuhiko, additional

Published
2023
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27. Comparison of Histological Sample Volumes among Various Endoscopic Ultrasound-Guided Biopsy Needles

Author

Takahashi, Kosuke, primary, Yasuda, Ichiro, additional, Hanaoka, Tatsuyuki, additional, Hayashi, Yuka, additional, Motoo, Iori, additional, Kajiura, Shinya, additional, Ando, Takayuki, additional, Fujinami, Haruka, additional, Tajiri, Kazuto, additional, Imura, Johji, additional, Ozawa, Eisuke, additional, Miuma, Satoshi, additional, Miyaaki, Hisamitsu, additional, and Nakao, Kazuhiko, additional

Published
2021
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33. Serum exosomal microRNA?122 and microRNA?21 as predictive biomarkers in transarterial chemoembolization?treated hepatocellular carcinoma patients

Author

Suehiro, Tomoyuki, Miyaaki, Hisamitsu, Kanda, Yasuko, Shibata, Hidetaka, Honda, Takuya, Ozawa, Eisuke, Miuma, Satoshi, Taura, Naota, Nakao, Kazuhiko, Suehiro, Tomoyuki, Miyaaki, Hisamitsu, Kanda, Yasuko, Shibata, Hidetaka, Honda, Takuya, Ozawa, Eisuke, Miuma, Satoshi, Taura, Naota, and Nakao, Kazuhiko

Abstract

Exosomal microRNAs (miRNAs) have been investigated as potential novel biomarkers, and miR-122 and miR-21 were shown to be important in hepatocellular carcinoma (HCC). We analyzed the importance of serum exosomal miRNA expression levels in HCC patients that underwent transarterial chemoembolization (TACE). Seventy-five HCC patients who underwent TACE as the initial treatment in Nagasaki University Hospital were enrolled. Exosomal miRNAs were isolated from serum samples collected before and after TACE. Exosomal miR-122 expression levels significantly decreased after TACE (P=0.012), while the exosomal miR-21 expression levels did not significantly change. The expression levels of exosomal miR-122 before TACE were shown to correlate significantly with aspartate aminotransferase (r=0.31, P=0.004) and alanine aminotransferase (r=0.33, P=0.003) levels, tumor diameter (r=0.29, P=0.010) and Child-Pugh score (r=-0.28, P=0.013). The median survival time for all patients was 47 months, and neither of the investigated exosomal miRNAs were shown to be independent factors associated with the disease-specific survival. According to the median relative expression of miR-122 after TACE/before TACE (miR-122 ratio) in liver cirrhosis patients (n=57), the patients with a higher miR-122 ratio had significantly longer disease-specific survival, compared with that of the patients with the lower miR-122 ratio (P=0.0461). Multivariate Cox proportional hazards regression analysis of clinical parameters revealed that a lower exosomal miR-122 ratio (HR 2.720; 95% confidence interval, 1.035-8.022; P=0.042) is associated with the disease-specific survival. Taken together, our results demonstrate that the exosomal miR-122 level alterations may represent a predictive biomarker in HCC patients with liver cirrhosis treated with TACE., identifier:Oncology Letters, 16(3), pp.3267-3273; 2018

Published
2020

34. Treatment of Hepatitis C Virus Infection with Direct-acting Antiviral Agents Elevates the Serum Small-dense Low-density Lipoprotein Cholesterol Level

Author

Hino, Naoyuki, primary, Sasaki, Ryu, additional, Takahashi, Youichi, additional, Koike, Makiko, additional, Fukushima, Masanori, additional, Haraguchi, Masafumi, additional, Honda, Takuya, additional, Miuma, Satoshi, additional, Ozawa, Eisuke, additional, Miyaaki, Hisamitsu, additional, Ichikawa, Tatsuki, additional, and Nakao, Kazuhiko, additional

Published
2021
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37. Mo1142 MACHINE LEARNING-BASED MODEL FOR PREDICTION AND FEATURE ANALYSIS OF RECURRENCE IN PANCREATIC NEUROENDOCRINE TUMORS G1/G2

Author

Murakami, Masatoshi, Fujimori, Nao, Nakata, Kohei, Nakamura, Masafumi, Hashimoto, Shinichi, Nishihara, Kazuyoshi, Hashigo, Shunpei, Ozawa, Eisuke, Okamoto, Kazuhisa, Ishida, Yusuke, Okano, Keiichi, Takaki, Ryo, Shimamatsu, Yutaka, Ito, Tetsuhide, Miki, Masami, Oza, Noriko, Yamaguchi, Daisuke, Yamamoto, Hirofumi, Takedomi, Hironobu, Kawabe, Ken, Akashi, Tetsuro, Miyahara, Koichi, Ohuchida, Jiro, Nagai, Eishi, Yohei, Nakashima, and Ogawa, Yoshihiro

Published
2023
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38. Significance of hepatitis B virus core-related antigen and covalently closed circular DNA levels as markers of hepatitis B virus re-infection after liver transplantation

Author

Matsuzaki, Toshihisa, Tatsuki, Ichikawa, Otani, Masashi, Akiyama, Motohisa, Ozawa, Eisuke, Miuma, Satoshi, Miyaaki, Hisamitsu, Taura, Naota, Hayashi, Tomayoshi, Okudaira, Sadayuki, Takatsuki, Mitsuhisa, Isomoto, Hajime, Takeshima, Fuminao, Eguchi, Susumu, and Nakao, Kazuhiko

Published
2013
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47. Tu1405 EVALUATION OF THE NEW 22-GAUGE EUS GUIDED BIOPSY NEEDLE (ACQUIRE) COMPARING TO ANOTHER NEW 20-GAUGE FNA NEEDLE WITH FORWARD-CUTTING BEVEL (PROCORE) IN PATIENTS WITH AUTOIMMUNE PANCREATITIS: A MULTICENTER RANDOMIZED TRIAL IN WEST JAPAN

Author

Kurita, Akira, primary, Zen, Yoh, additional, Yasukawa, Satoru, additional, Yoshimura, Ken-ichi, additional, Ogura, Takeshi, additional, Ozawa, Eisuke, additional, Okabe, Yoshinobu, additional, Asada, Masanori, additional, Nebiki, Hiroko, additional, Shigekawa, Minoru, additional, Ikeura, Tsukasa, additional, Eguchi, Takaaki, additional, Maruyama, Hirotsugu, additional, Ueki, Toshiharu, additional, Itonaga, Masahiro, additional, Hashimoto, Shinichi, additional, Shiomi, Hideyuki, additional, Minami, Ryuki, additional, Hoki, Noriyuki, additional, Takenaka, Mamoru, additional, Itokawa, Yoshio, additional, Uza, Norimitsu, additional, Hashigo, Shunpei, additional, Yasuda, Hiroaki, additional, Takada, Ryoji, additional, Kamada, Hideki, additional, Kawamoto, Hirofumi, additional, Kawakami, Hiroshi, additional, Moriyama, Ichiro, additional, Fujita, Koichi, additional, Hanada, Keiji, additional, Matsumoto, Hisakazu, additional, and Yazumi, Shujiro, additional

Published
2019
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48. Current characteristics of hemophilia patients co?infected with HIV/HCV in Japan

Author

Miuma, Satoshi, Hidaka, Masaaki, Takatsuki, Mitsuhisa, Natsuda, Koji, Soyama, Akihiko, Miyaaki, Hisamitsu, Kanda, Yasuko, Tamada, Yoko, Shibata, Hidetaka, Ozawa, Eisuke, Taura, Naota, Eguchi, Susumu, Nakao, Kazuhiko, Miuma, Satoshi, Hidaka, Masaaki, Takatsuki, Mitsuhisa, Natsuda, Koji, Soyama, Akihiko, Miyaaki, Hisamitsu, Kanda, Yasuko, Tamada, Yoko, Shibata, Hidetaka, Ozawa, Eisuke, Taura, Naota, Eguchi, Susumu, and Nakao, Kazuhiko

Abstract

Over 30 years have passed since co-infection with human immunodeficiency virus (HIV)/hepatitis C virus (HCV) was first documented in hemophilia patients in Japan. In such cases, the leading cause of mortality is reportedly HCV-associated end-stage liver disease. However, the current characteristics of hemophilia patients co-infected with HIV/HCV are unknown. The aim of the present study was to reveal the current characteristics, notably HCV geno-prevalence and liver function, among hemophilia patients co-infected with HIV/HCV in Japan. Current characteristics were evaluated using cross-sectional retrospective data of 44 hemophilia patients positive for anti-HCV and anti-HIV antibodies who underwent screening of liver dysfunction. A total of 56.8% of hemophilia patients co-infected with HIV/HCV were positive for HCV RNA. The most common HCV genotypes were 1a, 1b and 3a. Liver cirrhosis was diagnosed in 26.3% patients negative for HCV RNA and 60.0% patients positive for HCV RNA. Decompensated liver cirrhosis was diagnosed in 33.3% HCV RNA-positive patients and none of the HCV RNA-negative patients. The rate of liver cirrhosis was greater for HCV genotype 3a compared with other genotypes. Overall, the current primary HCV RNA genotypes among hemophilia patients co-infected with HIV/HCV are 1a, 1b and 3a. Over 50% of HIV/HCV co-infected hemophilia patients positive for HCV RNA were diagnosed with liver cirrhosis and some were diagnosed with decompensated liver cirrhosis., Experimental and Therapeutic Medicine, 15(2), pp.2148-2155; 2018

Published
2018

49. Study on prevention of hypercapnia by nasal high flow in patients undergoing endoscopic retrograde cholangiopancreatography during intravenous anesthesia.

Author

Takao Ayuse, Hironori Sawase, Eisuke Ozawa, Kazuyoshi Nagata, Naohiro Komatsu, Takuro Sanuki, Shinji Kurata, Gaku Mishima, Naoki Hosogaya, Sawako Nakashimad, Pinkham, Max, Stanislav Tatkov, Nakao Kazuhiko, Ayuse, Takao, Sawase, Hironori, Ozawa, Eisuke, Nagata, Kazuyoshi, Komatsu, Naohiro, Sanuki, Takuro, and Kurata, Shinji

Published
2020
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