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1. Multi Positive Contrastive Learning with Pose-Consistent Generated Images

Author

Inayoshi, Sho, Widya, Aji Resindra, Ozaki, Satoshi, Otsuka, Junji, and Ohashi, Takeshi

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Model pre-training has become essential in various recognition tasks. Meanwhile, with the remarkable advancements in image generation models, pre-training methods utilizing generated images have also emerged given their ability to produce unlimited training data. However, while existing methods utilizing generated images excel in classification, they fall short in more practical tasks, such as human pose estimation. In this paper, we have experimentally demonstrated it and propose the generation of visually distinct images with identical human poses. We then propose a novel multi-positive contrastive learning, which optimally utilize the previously generated images to learn structural features of the human body. We term the entire learning pipeline as GenPoCCL. Despite using only less than 1% amount of data compared to current state-of-the-art method, GenPoCCL captures structural features of the human body more effectively, surpassing existing methods in a variety of human-centric perception tasks.

Published
2024

5. Study on the Impact of Learning About Information Security Measures on Mental Models: Applying Cybersecurity Frameworks to Self-learning Materials

Author

Ozaki, Satoshi, Furukawa, Hiroshi, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, and Moallem, Abbas, editor

Published
2021
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7. The Influence of Age on the Outcomes of Traumatic Brain Injury: Findings from a Japanese Nationwide Survey (J-ASPECT Study-Traumatic Brain Injury)

Author

Takigami, Masayoshi, Kamiyama, Kenji, Houkin, Kiyohiro, Nishi, Shougo, Yoshimoto, Tetsuyuki, Kaneko, Sadao, Oka, Koji, Ooyama, Hiroshi, Kamada, Kyousuke, Makino, Kenichi, Tokumitsu, Naoki, Sako, Kazuhiro, Suzuki, Susumu, Suzuki, Nozomi, Izumi, Naoto, Nitta, Kazumi, Ootaki, Masahumi, Isobe, Masanori, Nishiya, Mikio, Yamazaki, Takaaki, Mabuchi, Syouji, Ogasawara, Kuniaki, Kubo, Naohiko, Shimizu, Yukihiko, Saito, Keiichi, Yamanome, Tatumi, Yoshino, Atsuo, Fujitsuka, Mitsuyuki, Takami, Masaaki, Ohtaka, Hirotoshi, Hirano, Teruyuki, Shiokawa, Yosiaki, Okada, Takaharu, Suzuki, Ichiro, Kohno, Michihiro, Haraoka, Jou, Arai, Yoshinori, Kawamura, Noriyoshi, Isoshima, Akira, Yasue, Masaharu, Takayoshi Kobayashi, Mitsuhiko Hokari, Kawai, Kensuke, Maehara, Taketoshi, Arai, Hajime, Noguchi, Makoto, Hoshino, Haruhiko, Hiyama, Hirofumi, Yoshida, Kensaku, Utsugi, Osamu, Takeda, Yasuaki, Tamaki, Kouichi, Karasudani, Hirohide, Urabe, Takao, Kobayashi, Shiro, Nakamura, Michio, Koguchi, Yorio, Ono, Junichi, Suda, Sumio, Hadeishi, Hiromu, Fukutake, Toshio, Wakui, Kenji, Tanno, Hirokazu, Ishige, Naoki, Ohasi, Takashi, Sakai, Hideki, Nishimura, Yasuaki, Watanabe, Takayuki, Matsumoto, Takashi, Koketsu, Naoki, Hirose, Yuichi, Doyu, Manabu, Hasegawa, Toshinori, Kuwayama, Naoto, Terao, Shinichi, Mizutani, Nobuhiko, Suzaki, Noriyuki, Okuda, Satoshi, Yasui, Keizo, Seki, Yukio, Hasegawa, Yasuhiro, Ikeda, Akira, Takeuchi, Youtarou, Ohara, Sigeki, Araki, Yoshio, Wakabayashi, Toshihiko, Tanaka, Hisashi, Yoshimoto, Junpei, Sugiura, Makoto, Koichiro, Ogura, Kobayashi, Nozomu, Yamada, Tomonori, Kato, Amami, Toshiho, Ohtsuki, Wakayama, Akatsuki, Takahashi, Jun, Kataoka, Hiroharu, Yoshimine, Toshiki, Nakajima, Yoshikazu, Gi, Hidehuku, Uranishi, Ryunosuke, Nakamura, Yusaku, Yamanaka, Kazunori, Ohmori, Kazumi, Matsumoto, Hiroyuki, Oiwa, Yoshitugu, Uemura, Yosihiko, Fujiwara, Hiroaki, Iwai, Yoshiyasu, Morikawa, Masashi, Tane, Kazuyuki, Hashikawa, Kazuo, Fujinaka, Toshiyuki, Yoneda, Shunichi, Yamashita, Kohsuke, Kitano, Masahiko, Tominaga, Shinsuke, Nakamura, Kazuhito, Kono, Katsuhiko, Ohata, Kenji, Taniguchi, Hirokatsu, Hazama, Takanori, Kuroiwa, Toshihiko, Tamura, Yoji, Maeno, Kazusige, Arai, Motohiro, Iwase, Masaaki, Hashimoto, Kenji, Yamada, Keisuke, Turuno, Takashi, Ichinose, Tsutomu, Kurokawa, Shinichiro, Matsuyama, Takeshi, Fujita, Toshiaki, Yuguchi, Takamichi, Teramoto, Yoshihumi, Kakita, Hiroto, Matsuo, Takayuki, Izumo, Tsuyoshi, Ryu, Nobutoshi, Naoki Kitagawa, Wataru Haraguchi, Kaminogo, Makio, Sakamoto, Seisaburo, Tokunaga, Yosiharu, Urasaki, Ei-Ichirou, Kuratsu, Junichi, Takada, Akira, Terasaki, Tadashi, Hisami Oosima, Isao Fuwa, Yamashiro, Shigeo, Hiromasa Tsuiki, Makoto Yoshikawa, Koga, Kazunari, Egami, Hiroshi, Kawamura, Tadao, Mitsuo, Kunihiko, Masaki Morisige, Takamitu Hikawa, Takeda, Yuu, Yamaguchi, Yutaka, Shunro Uchinokura, Shiro Miyata, Goya, Tomokazu, Takeshima, Hideo, Yatsushiro, Kazutaka, Ohta, Hajime, Nagadou, Tatsui, Hirahara, Kazuho, Obara, Souichi, Seto, Hiroshi, Moroki, Koiti, Arita, Kazunori, Ishiuchi, Shogo, Uchihara, Toshimitsu, Mekaru, Susumu, Nagamine, Tomoaki, Jin Momoji, Naoki Tomiyama, Atusi Kimoto, Kouzi Idomari, Kadekaru, Tsutomu, Syamoto, Hirosi, Sasaki, Osamu, Minagawa, Makoto, Takahashi, Hideaki, Hiroyuki Arai, Kiyoshi Onda, Takeuchi, Shigekazu, Abe, Hiroshi, Fukuda, Osamu, Kouno, Mitsuo, Tamura, Tetsuro, Michiya Kubo, Yukio Horie, Hondo, Hiroaki, Takada, Hisashi, Masuoka, Toru, Shirasaki, Naoki, Nitta, Hisashi, Yasuo Katsuki, Makoto Kimura, Hisato Minamide, Yutaka Hayashi, Munemoto, Shigeru, Ikeda, Kiyonobu, Yutaka Hayashi, Mitsutoshi Nakada, Sato, Syuji, Hatano, Taketo, Yamamura, Osamu, Kabuto, Masanori, Jyunya Hayashi, Takahiro Sakuma, Kinouchi, Hiroyuki, Koizumi, Hidehito, Imae, Syougo, Fujita, Manabu, Suga, Masakazu, Kanehisa Kohno, Shinji Iwata, Zenke, Kiichiro, Fujisawa, Mutsuo, Mizobuchi, Hikaru, Hayashi, Satoru, Morimoto, Masanori, Ueba, Tetsuya, Nishimura, Hiroyuki, Ikawa, Naoki, Matsumoto, Yuzo, Kannuki, Seiji, Kagawa, Masahiro, Hayashi, Naoki, Atsushi Shindo, Takashi Tamiya, Yoshino, Kimihiro, Masaoka, Tetsuya, Nakahara, Ichiro, Satoshi Suzuki, Akira Nakamizo, Okamoto, Yuji, Takahashi, Haruki, Iihara, Koji, Hirakawa, Katsuyuki, Nagata, Shinji, Ookura, Akio, Yoshiro Kaneko, Hidenori Yoshida, Nakane, Hiroshi, Inoue, Isao, Hitotsumatsu, Tsutomu, Kouichi Kuramoto, Terukazu Kuramoto, Hiromichi Ooishi, Yoshihisa Matumoto, Masani Nonaka, Tooru Inoue, Morioka, Motohiro, Shuji Sakata, Hiroshi Sugimori, Takashima, Hiroshi, Ishihara, Shin-Ichiro, Suzuyama, Kenji, Miyazono, Masayuki, Itaro Hattori, Masafumi Morimoto, Ozaki, Satoshi, Hirota, Nobuo, Yasuhiko Mochimatsu, Yasunori Takemoto, Takagi, Makoto, Kenji Nakayama, Isao Yamamoto, Hiroshi Tanaka, Yoshinori Uchida, Sakata, Katsumi, Nobutaka, Kawahara, Nomura, Motohiro, Ozawa, Hitoshi, Tsumura, Kotaro, Michiyuki Maruyama, Makoto Inaba, Mori, Tatsuro, Mori, Takahisa, Sugitani, Masato, Tanaka, Yuichiro, Yamada, Masaru, Matsumae, Mitsunori, Onitsuka, Keiichirou, Tatsuya Takahashi, Kosuke Miyahara, Endou, Sumio, Takahashi, Hidekazu, Kaidu, Hiroyuki, Chikashi Maruki, Akira Tsunoda, Fujimaki, Takamitsu, Ooigawa, Hidetoshi, Masatsugu Uchida, Masahiko Tanaka, Kouiti Katoh, Hiroshi Wanihuti, Hyodo, Akio, Asakura, Ken, Nakajima, Shigeyoshi, Kanzawa, Takao, Kurihara, Hideyuki, Ohmori, Sigehiro, Hiroshi Kusunoki, Mitsugi Yoshinao, Magarisawa, Satoshi, Okabe, Shinichi, Kujiraoka, Yuuji, Tsuruoka, Shin, Takeshita, Mikihiko, Akira Matsumura, Tetsuya Yamamoto, Uemura, Kazuya, Tabata, Hitoshi, Sonobe, Makoto, Ryoji Yoshida, Masashi Nakatsukasa, Shimoeda, Norifumi, Kunimine, Hideo, Ishihara, Masayuki, Murai, Nozomu, Murakami, Nobukuni, Kidooka, Minoru, Iwamoto, Yoshihiro, Tenjin, Hiroshi, Masahiko Takamasu, Kouji Shiga, Mori, Nobuhito, Kose, Shigeru, Kohmura, Eiji, Matsumoto, Keigo, Sakaki, Takayuki, Miyake, Hiroji, Mabuchi, Eiichiro, Yokota, Masayuki, Yosihiro Kuga, Hideyuki Ohnishi, Kimura, Mitsuru, Masaaki Saiki, Osamu Narumi, Nakajima, Norio, Asahi, Minoru, Koyama, Junji, Noda, Shinya, Iida, Junichi, Fujita, Toyohisa, Nakase, Hiroyuki, Toru Hoshida, Hidehiro Hirabayashi, Fujimoto, Takayoshi, Nakao, Naoyuki, Tanaka, Yoshiyuki, Ozaki, Fuminori, Nakamura, Yoshinari, Miki, Kazuhito, Watanabe, Takashi, Hasegawa, Seiko, Konno, Hiromu, Takemura, Atsuhito, Okubo, Atsuya, Saito, Hitoshi, Taizen Nakase, Tatsuya Ishikawa, Toshio Sasajima, Hiroaki Shimizu, Sasou, Masayuki, Watanabe, Yoichi, Kiyoshi Saito, Taku Sato, Masahiro Satoh, Satoshi Taira, Koizumi, Takayuki, Shoji Mashiyama, Yasuhiro Suzuki, Oikawa, Tomoyoshi, Sonoda, Yukihiko, Shinjiro Saito, Rei Kondo, Shinoda, Atsuo, Kamatsuka, Eiichiro, So, Keiten, Kinjo, Toshihiko, Kennji Itou, Tooru Sasaki, Hiroaki Shimizu, Hidenori Endo, Karibe, Hirosi, Takahashi, Kou, Nakajima, Masayuki, Watanabe, Kazuyoshi, Takayama, Motohiro, Komuro, Taro, Fumio Suzuki, Hisao Hirai, Suzuki, Hidenori, Murata, Hiroto, Miya, Fumitaka, Kanamaru, Kenji, Tamura, Akira, Harada, Kiyoshi, Fukazawa, Seiji, Takehara, Seiya, Watanabe, Yoshihiko, Nakayama, Teiji, Hiroshi Nagura, Haruhiko Sato, Chiharu Tanoi, Shinji Amano, Kuroda, Katsuhiro, Morooka, Satoru, Masashi Kitagawa, Takafumi Wataya, Koide, Kazuo, Tanigawara, Tetsuya, Iwama, Toru, Ito, Junki, Noda, Shinji, Kouno, Kazuyuki, Kitazawa, Kazuo, Toshiki Takemae, Yoshikazu Kusano, Hokama, Masanobu, Yoshihisa Nishiyama, Hiroki Sato, Seguchi, Tatsuya, Yoshihiko Inui, Sumio Kobayashi, Oohigashi, Youji, Muraoka, Shinsuke, Miyatake, Masaki, Nakagawa Shinichi, Kensuke Hayashida, Inoue, Atsushi, Sakai, Keiichi, Yamaguchi, Shuhei, Fusao Ikawa, Tatsuya Mizoue, Hideki Irie, Gen Ishida, Kagawa, Takato, Namba, Yoichiro, Nakashima, Hiroyuki, Koji Abe, Isao Date, Uno, Masaaki, Sen Yamagata, Masaki Chin, Soitiro Takao, Hidemiti Sasayama, Kouji Muneda, Hideyuki Yoshida, Watanebe, Akira, Katou, Syouichi, Hamada, Yasuhiro, Suzuki, Michiyasu, Nishizaki, Takafumi, Yamashita, Katsuhiro, Ryuji Nakamura, Takaharu Nakamura, Wakabayashi, Shinichi, Okazaki, Takahito, Kurisu, Kaoru, Matsumoto, Masayasu, Katsuzo Kiya, Atsushi Tominaga, Syuichi Oki, Masaaki Shibukawa, Nakahara, Toshinori, Okita, Shinji, Torii, Tuyosi, Kenjirou Fujiwara, Minoru Nakagawa, Syuuhei Nishimura, Takashi Matsuoka, Naoyuki Isobe, Osamu Hamasaki, Shinji Nagahiro, Junichiro Satomi, Agawa, Masahito, Oka, Hirofumi, Yoshimura, Kunikazu, Kato, Tsutomu, Satoshi Minoshima, Nobuaki Kobayasi, Mikuni, Nobuhiro, Tanikawa, Rokuya, Sasaki, Jyunkou, Otawara, Yasunari, Tominaga, Teiji, Sasaki, Tatsuya, Takemura, Sunao, Kawakami, Masahisa, Ihara, Satoshi, Shibata, Yasushi, Saegusa, Takashi, Iuchi, Toshihiko, Ito, Chiaki, Okuda, Osamu, Yoshida, Kazunari, Masateru Katayama, Sadao Suga, Akihiro, Oikawa, Miura, Naohisa, Ota, Takahiro, Kumabe, Toshihiro, Suzuki, Sachio, Kumagai, Takashi, Nishimaki, Keiichi, Hongo, Kazuhiro, Shigeta, Hiroaki, Hattori, Kazuyoshi, Uozumi, Yoichi, Nakahara, Norimoto, Hashimoto, Nobukazu, Shu Imai, Shinichi Shirakami, Okumura, Yoshinari, Kazuhiro Yokoyama, Ryo Tamaki, Miyamoto, Susumu, Yamamoto, Kazuo, Ichioka, Tsugumichi, Inoue, Tsuyoshi, Kinoshita, Manabu, Saitoh, Minoru, Aihara, Hideo, Miyake, Hajimu, Tukasa Nishiura, Kotaro Ogihara, Nishino, Shigeki, Miyoshi, Yasuyuki, Arisawa, Tadashi, Shoji Tsuchimoto, Shigeru Daido, Kinoshita, Kimihisa, Keisuke Migita, Kiyoshi Yuki, Akatsuka, Keiichi, Fujisawa, Hirosuke, Shono, Tadahisa, Tsugu, Hitoshi, Hayashi, Shuji, Toshio Matsushima, Tatsuya Abe, Nakashima, Susumu, Tuji, Takehisa, Kaga, Akihiko, Kanemaru, Reizou, Takasaki, Koji, Imamura, Junichi, Noha, Masahiro, Watanabe, Saburo, Sakai, Nobuyuki, Hiroaki Minami, Yasuhisa Yoshida, Okumura, Tomoyoshi, Nishimura, Shinjitsu, Numazawa, Shinichi, Masanori Tsutsumi, Kiyoshi Kazekawa, Fukuyama, Kouzou, Fujimoto, Yasuhiro, Yamagami, Keitaro, Kurogi, Ryota, Kurogi, Ai, Nishimura, Kunihiro, Onozuka, Daisuke, Ren, Nice, Kada, Akiko, Nishimura, Ataru, Arimura, Koichi, Ido, Keisuke, Mizoguchi, Masahiro, Sakamoto, Tetsuya, Kayama, Takamasa, and Hagihara, Akihito

Published
2019
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12. Ionic conductivity of the LiOH-Li2SO4 system and fabrication of all-solid-state lithium batteries.

Author

Miyazaki, Reona, Yagi, En, Ozaki, Satoshi, Suto, Yusaku, Onishi, Harunobu, Sato, Yosuke, Yoshida, Toshihiro, and Katsuda, Yuji

Subjects
SUPERIONIC conductors, LITHIUM cells, SOLID state batteries, IONIC conductivity, SOLID electrolytes, DEW point, HOT pressing
Abstract

The solid electrolytes with a low melting temperature are promising for the all-solid-state lithium batteries because such electrolytes enable the battery fabrication without high-temperature sintering (for example, ~ 1000 °C for oxide materials). In this study, a series of LiOH-Li2SO4 systems with different LiOH/Li2SO4 ratios is fabricated by melting LiOH and Li2SO4 at 430 °C, and their ion conduction properties are investigated. The stoichiometric compounds are obtained in 2.2LiOH‧Li2SO4 without segregation of LiOH and Li2SO4, which is rather different from the previously known composition (3LiOH‧Li2SO4). The deviation from this LiOH/Li2SO4 fraction results in a segregation of LiOH or Li2SO4. The conductivities of 2.2LiOH‧Li2SO4 with 5 mol% of Li3BO3 are 1.9 × 10−6 and 6.0 × 10−3 S/cm at 25 and 150 °C, respectively. The all-solid-state batteries are fabricated by hot pressing the solid electrolyte with Li(Ni0.3Co0.6Mn0.1)O2 (cathode) and graphite (anode) at 250 °C under 150 MPa. The contacts of the solid electrolyte with Li(Ni0.3Co0.6Mn0.1)O2 and graphite are intimate, and the by-products are not found at the interphase. The discharge capacities of 80 mAh/g are obtained for 100 cycles at 150 °C when the charging voltage is restricted to 3.95 V. The results of cyclic voltammetry measurement indicate the reductive decomposition of the solid electrolyte at 2.3 and 1.6 V. These reduction currents are decreased with cycling, suggesting the passivation of the anode interphase. On the other hand, the oxidation current is observed above 3.6 V which is not terminated during voltage cycling. In the battery fabrication process, high-temperature sintering is not necessary, and the dense contacts with electrode materials can be made by hot pressing at 250 °C. Furthermore, the batteries are constructed in a dry room where the dew point is maintained at − 40 °C. The present results suggest the potential of the LiOH-Li2SO4 as the solid electrolyte for all-solid-state lithium batteries. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Technical implementation of feasibility study-II design

Author

Zisman, Michael S., Ozaki, Satoshi, and Palmer, Robert B.

Subjects
Particle accelerators, Physics of elementary particles and fields, Neutrino Factory
Abstract

An updated Feasibility Study for a high-performance Neutrino Factory has been undertaken by Brookhaven National Laboratory (BNL) and the Neutrino Factory and Muon Collider Collaboration (MC). We describe the technical implementation of the facility. Details of the key components are shown, and R & D activities that need to be addressed to proceed toward a facility design are indicated.

Published
2001

15. The efficacy and practicality of the Neuro-track Cognitive Battery assessment for utilization in clinical settings for the identification of cognitive decline in an older Japanese population.

Author

Glenn, Jordan M., Bryk, Kelsey, Myers, Jennifer R., Anderson, John, Onguchi, Kaori, McFarlane, Jacob, and Ozaki, Satoshi

Subjects
COGNITION disorders diagnosis, RESEARCH methodology evaluation, RESEARCH methodology, NEUROPSYCHOLOGICAL tests, PSYCHOLOGICAL tests, SENSITIVITY & specificity (Statistics), OLD age
Abstract

Introduction: Japan has the largest aging population with 33% of the population over the age of 60 years. The number of Japanese adults with dementia is estimated to be approximately 4.6 million, comprising nearly 15% of the older adult population. It is critical to administer cognitive assessments early in the disease state that have high reliability and low user burden to detect negative cognitive changes as early as possible; however, current preclinical AD detection methods are invasive, time-consuming, and expensive. A number of traditional and digital cognitive assessments are also available, but many of these tests are time-consuming, taxing to the user, and not widely scalable. The purpose of this study was to incorporate a digital cognitive assessment battery into a standard clinical assessment performed within a Japanese-based neuropsychology clinic to assess the diagnostic accuracy and the relationship between the digital Neurotrack Cognitive Assessment Battery (N-CAB) to traditional cognitive assessments. Methods: Healthy individuals and probable Alzheimer’s patients completed the N-CAB, as well as two traditional cognitive assessments, the Mini Mental Status Exam (MMSE) and the Revised Hasegawa’s Dementia Scale (HDS-R). Results: Our results demonstrate the Image Pairs hand-response phase of the NCAB had the highest diagnostic accuracy with 95% sensitivity and 89% specificity to probable Alzheimer’s disease. This was closely followed by the Symbol Match assessment, with a 96% sensitivity and 74% specificity to probable Alzheimer’s disease. Additionally, Symbol Match and Path Points used in combination resulted in a sensitivity of 94%, specificity of 90%; a model with all N-CAB assessments resulted in a sensitivity and specificity of 100%. All N-CAB assessments had moderate to strong and significant correlations with the MMSE and HDS-R. Discussion: Together, this suggests that the N-CAB assessment battery may be an appropriate alternative for the clinical screening of cognition for earlier detection of Alzheimer’s disease. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Imaging pituitary vasopressin 1B receptor in humans with the novel PET radiotracer 11C-TASP699

Author

Naganawa, Mika, B. Nabulsi, Nabeel, Matuskey, David, Henry, Shannan, Ropchan, Jim, Shu-Fei, Lin, Gao, Hong, Pracitto, Richard, Labaree, David, Zhang, Ming-Rong, Tetsuya, Suhara, Nishino, Izumi, Sabia, Helene, Ozaki, Satoshi, Huang, Yiyun, and E. Carson, Richar

Abstract

Arginine vasopressin (AVP) is a hormone that is mainly synthesized in the hypothalamus and stored in the posterior pituitary. Receptors for vasopressin are categorized into at least three subtypes (V1A, V1B, V2). Among these subtypes, the V1B receptor (V1BR), highly expressed in the pituitary, is a primary regulator of the hypothalamic-pituitary-adrenal axis activity, and thus a potential target for the treatment of neuropsychiatric disorders, such as depression and anxiety. 11C-TASP699 is a novel PET radiotracer with high affinity and selectivity for the V1BR. The purpose of this study was to characterize the pharmacokinetic and binding profiles of 11C-TASP699 in human and determine its utility in an occupancy study of a novel V1BR antagonist, TS-121. Methods: Six healthy subjects were scanned twice with 11C-TASP699 to determine the most appropriate kinetic model for analysis of imaging data and test-retest reproducibility of outcome measures. Nine healthy subjects were scanned before and after administration of TS-121 (active component: THY1773) to assess V1BR occupancy. Metabolite-corrected arterial input functions were obtained. Pituitary time-activity curves were analyzed with one- and two-tissue compartment (1TC, 2TC) models and multilinear analysis 1 (MA1) to calculate distribution volumes (VT). Relative testretest variability (TRV) and absolute test-retest variability (aTRV) were calculated. Since no brain region could be used as a reference region, percent change in VT after TS-121 administration was computed to assess its receptor occupancy and correlate with plasma concentration of the drug. Results: 11C-TASP699 showed high uptake in the pituitary and no uptake in any brain regions. The 2TC model provided better fits than the 1TC model. The MA1 VT estimates were very similar to the 2TC VT estimates, so MA1 was the model of choice. TRV of VT was good (TRV: -2±14%, aTRV: 11%). THY1773 reduced VT in a dose-dependent fashion, with IC50 of 177±52 ng/mL in plasma concentration. There were no adverse events resulting in discontinuation from the study. Conclusion: 11C-TASP699 was shown to display appropriate kinetics in human with substantial specific binding and good reproducibility of VT. Therefore, this tracer is suitable for measurement of the V1BR in human pituitary and V1BR occupancy of TS-121, a novel V1BR antagonist.

Published
2021

18. On Scalability of DHT-DNS Hybrid Naming System

Author

Doi, Yusuke, Wakayama, Shirou, Ishiyama, Masahiro, Ozaki, Satoshi, Inoue, Atsushi, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Cho, Kenjiro, editor, and Jacquet, Philippe, editor

Published
2006
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20. Evaluation of [18F]MK-0911, a positron emission tomography (PET) tracer for opioid receptor-like 1 (ORL1), in rhesus monkey and human

Author

Hostetler, Eric D., Sanabria-Bohórquez, Sandra, Eng, Waisi, Joshi, Aniket D., Patel, Shailendra, Gibson, Raymond E., O'Malley, Stacey, Krause, Stephen M., Ryan, Christine, Riffel, Kerry, Bi, Sheng, Okamoto, Osamu, Kawamoto, Hiroshi, Ozaki, Satoshi, Ohta, Hisashi, de Groot, Tjibbe, Bormans, Guy, Depré, Marleen, de Hoon, Jan, De Lepeleire, Inge, Reynders, Tom, Cook, Jacquelynn J., Burns, H. Donald, Egan, Michael, Cho, William, van Laere, Koen, and Hargreaves, Richard J.

Published
2013
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24. Synthesis, characterization, and monkey positron emission tomography (PET) studies of [18F]Y1-973, a PET tracer for the neuropeptide Y Y1 receptor

Author

Hostetler, Eric D., Sanabria-Bohórquez, Sandra, Fan, Hong, Zeng, Zhizhen, Gantert, Liza, Williams, Mangay, Miller, Patricia, O'Malley, Stacey, Kameda, Minoru, Ando, Makoto, Sato, Nagaaki, Ozaki, Satoshi, Tokita, Shigeru, Ohta, Hisashi, Williams, David, Sur, Cyrille, Cook, Jacquelynn J., Burns, H. Donald, and Hargreaves, Richard

Published
2011
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31. Imaging Pituitary Vasopressin 1B Receptor in Humans with the PET Radiotracer 11C-TASP699

Author

Naganawa, Mika, primary, Nabulsi, Nabeel B., additional, Matuskey, David, additional, Henry, Shannan, additional, Ropchan, Jim, additional, Lin, Shu-Fei, additional, Gao, Hong, additional, Pracitto, Richard, additional, Labaree, David, additional, Zhang, Ming-Rong, additional, Suhara, Tetsuya, additional, Nishino, Izumi, additional, Sabia, Helene, additional, Ozaki, Satoshi, additional, Huang, Yiyun, additional, and Carson, Richard E., additional

Published
2021
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40. High-contrast PET imaging of vasopressin V1B receptors with a novel radioligand, 11C-TASP699

Author

Koga, Kazumi, Nagai, Yuji, Hanyu, Masayuki, Yoshinaga, Mitsukane, Chaki, Shigeyuki, Ohtake, Norikazu, Ozaki, Satoshi, Zhang, Ming-Rong, Suhara, Tetsuya, and Higuchi, Makoto

Abstract

Vasopressin 1B receptors (V1BRs) are abundantly expressed in the pituitary, and in vivo positron emission tomography (PET) of V1BRs was recently enabled by our development of a specific radioligand, 11C-TASP0434299, derivatized from pyridopyrimidin-4-one. Here, we identified a novel pyridopyrimidin-4-one analog, N-tert-butyl-2-[2-(6-11C-methoxypyridine-2-yl)-6-[3-(morpholin-4-yl)propoxy]-4-oxopyrido[2,3-d]pyrimidin-3(4H)-yl]acetamide (11C-TASP0410699, hereafter referred to as 11C-TASP699), as a potent V1BR radioligand producing a higher image contrast for the target than 11C-TASP0434299. Methods: In vitro properties of TASP699 were assessed by assaying its affinity for human V1BR and its selectivity for off-target molecules. Radioactive uptakes in the pituitary were analyzed using PET in rhesus monkeys after intravenous administration of 11C-TASP699. Serial doses of a selective V1BR antagonist, 2-[2-(3-chloro-4-fluorophenyl)-6-[3-(morpholin-4-yl)propoxy]-4-oxopyrido[2,3-d]pyrimidin-3(4H)-yl]-N-isopropylacetamide hydrochloride (TASP0390325), were administered prior to the radioligand injection. Autoradiographic labeling of monkey pituitary slices with 11C-TASP699 was conducted with or without nonradioactive V1BR antagonists. Results: The half maximal inhibitory concentration (IC50) of TASP699 for human V1BRs (0.165 nM) was lower than that of TASP0434299 (0.526 nM), whereas its IC50 values for off-target molecules exceeded 1 μM. PET imaging in monkeys demonstrated that the peak pituitary uptake of 11C-TASP699 was almost equivalent to that of 11C-TASP0434299 and that pretreatment with TASP0390325 inhibited the retention of 11C-TASP699 in a dose-dependent manner, inducing nearly full occupancy at 0.3 mg/kg. Specific radioligand binding was determined as a specific-to-nondisplaceable uptake ratio at equilibrium using radioactivity retentions at 60 min in baseline and blocking studies. This ratio for 11C-TASP699 was approximately 2.5-fold greater than that of 11C-TASP0434299. A reverse-phase high performance liquid chromatography (HPLC) study identified the parent and polar radiometabolites. Affinities of two predicted metabolite candidates for V1BRs were more than ten times weaker than that of the parent. Intense autoradiographic labeling of the anterior pituitary with 11C-TASP699 was inhibited with TASP0390325 in a concentration-dependent manner. Conclusion:11C-TASP699 yielded PET images of pituitary V1BRs with a higher contrast than 11C-TASP0434299, supporting the applicability of 11C-TASP699 in the assessment of neuropsychiatric diseases and dose findings for test drugs in clinical trials.

Published
2017

47. The Influence of Age on the Outcomes of Traumatic Brain Injury: Findings from a Japanese Nationwide Survey (J-ASPECT Study-Traumatic Brain Injury)

Author

Yamagami, Keitaro, primary, Kurogi, Ryota, additional, Kurogi, Ai, additional, Nishimura, Kunihiro, additional, Onozuka, Daisuke, additional, Ren, Nice, additional, Kada, Akiko, additional, Nishimura, Ataru, additional, Arimura, Koichi, additional, Ido, Keisuke, additional, Mizoguchi, Masahiro, additional, Sakamoto, Tetsuya, additional, Kayama, Takamasa, additional, Suzuki, Michiyasu, additional, Arai, Hajime, additional, Hagihara, Akihito, additional, Iihara, Koji, additional, Takigami, Masayoshi, additional, Kamiyama, Kenji, additional, Houkin, Kiyohiro, additional, Nishi, Shougo, additional, Yoshimoto, Tetsuyuki, additional, Kaneko, Sadao, additional, Oka, Koji, additional, Ooyama, Hiroshi, additional, Kamada, Kyousuke, additional, Makino, Kenichi, additional, Tokumitsu, Naoki, additional, Sako, Kazuhiro, additional, Suzuki, Susumu, additional, Suzuki, Nozomi, additional, Izumi, Naoto, additional, Nitta, Kazumi, additional, Ootaki, Masahumi, additional, Isobe, Masanori, additional, Nishiya, Mikio, additional, Yamazaki, Takaaki, additional, Mabuchi, Syouji, additional, Ogasawara, Kuniaki, additional, Kubo, Naohiko, additional, Shimizu, Yukihiko, additional, Saito, Keiichi, additional, Yamanome, Tatumi, additional, Yoshino, Atsuo, additional, Fujitsuka, Mitsuyuki, additional, Takami, Masaaki, additional, Ohtaka, Hirotoshi, additional, Hirano, Teruyuki, additional, Shiokawa, Yosiaki, additional, Okada, Takaharu, additional, Suzuki, Ichiro, additional, Kohno, Michihiro, additional, Haraoka, Jou, additional, Arai, Yoshinori, additional, Kawamura, Noriyoshi, additional, Isoshima, Akira, additional, Yasue, Masaharu, additional, Takayoshi Kobayashi, Mitsuhiko Hokari, additional, Kawai, Kensuke, additional, Maehara, Taketoshi, additional, Noguchi, Makoto, additional, Hoshino, Haruhiko, additional, Hiyama, Hirofumi, additional, Yoshida, Kensaku, additional, Utsugi, Osamu, additional, Takeda, Yasuaki, additional, Tamaki, Kouichi, additional, Karasudani, Hirohide, additional, Urabe, Takao, additional, Kobayashi, Shiro, additional, Nakamura, Michio, additional, Koguchi, Yorio, additional, Ono, Junichi, additional, Suda, Sumio, additional, Hadeishi, Hiromu, additional, Fukutake, Toshio, additional, Wakui, Kenji, additional, Tanno, Hirokazu, additional, Ishige, Naoki, additional, Ohasi, Takashi, additional, Sakai, Hideki, additional, Nishimura, Yasuaki, additional, Watanabe, Takayuki, additional, Matsumoto, Takashi, additional, Koketsu, Naoki, additional, Hirose, Yuichi, additional, Doyu, Manabu, additional, Hasegawa, Toshinori, additional, Kuwayama, Naoto, additional, Terao, Shinichi, additional, Mizutani, Nobuhiko, additional, Suzaki, Noriyuki, additional, Okuda, Satoshi, additional, Yasui, Keizo, additional, Seki, Yukio, additional, Hasegawa, Yasuhiro, additional, Ikeda, Akira, additional, Takeuchi, Youtarou, additional, Ohara, Sigeki, additional, Araki, Yoshio, additional, Wakabayashi, Toshihiko, additional, Tanaka, Hisashi, additional, Yoshimoto, Junpei, additional, Sugiura, Makoto, additional, Koichiro, Ogura, additional, Kobayashi, Nozomu, additional, Yamada, Tomonori, additional, Kato, Amami, additional, Toshiho, Ohtsuki, additional, Wakayama, Akatsuki, additional, Takahashi, Jun, additional, Kataoka, Hiroharu, additional, Yoshimine, Toshiki, additional, Nakajima, Yoshikazu, additional, Gi, Hidehuku, additional, Uranishi, Ryunosuke, additional, Nakamura, Yusaku, additional, Yamanaka, Kazunori, additional, Ohmori, Kazumi, additional, Matsumoto, Hiroyuki, additional, Oiwa, Yoshitugu, additional, Uemura, Yosihiko, additional, Fujiwara, Hiroaki, additional, Iwai, Yoshiyasu, additional, Morikawa, Masashi, additional, Tane, Kazuyuki, additional, Hashikawa, Kazuo, additional, Fujinaka, Toshiyuki, additional, Yoneda, Shunichi, additional, Yamashita, Kohsuke, additional, Kitano, Masahiko, additional, Tominaga, Shinsuke, additional, Nakamura, Kazuhito, additional, Kono, Katsuhiko, additional, Ohata, Kenji, additional, Taniguchi, Hirokatsu, additional, Hazama, Takanori, additional, Kuroiwa, Toshihiko, additional, Tamura, Yoji, additional, Maeno, Kazusige, additional, Arai, Motohiro, additional, Iwase, Masaaki, additional, Hashimoto, Kenji, additional, Yamada, Keisuke, additional, Turuno, Takashi, additional, Ichinose, Tsutomu, additional, Kurokawa, Shinichiro, additional, Matsuyama, Takeshi, additional, Fujita, Toshiaki, additional, Yuguchi, Takamichi, additional, Teramoto, Yoshihumi, additional, Kakita, Hiroto, additional, Matsuo, Takayuki, additional, Izumo, Tsuyoshi, additional, Ryu, Nobutoshi, additional, Naoki Kitagawa, Wataru Haraguchi, additional, Kaminogo, Makio, additional, Sakamoto, Seisaburo, additional, Tokunaga, Yosiharu, additional, Urasaki, Ei-Ichirou, additional, Kuratsu, Junichi, additional, Takada, Akira, additional, Terasaki, Tadashi, additional, Hisami Oosima, Isao Fuwa, additional, Yamashiro, Shigeo, additional, Hiromasa Tsuiki, Makoto Yoshikawa, additional, Koga, Kazunari, additional, Egami, Hiroshi, additional, Kawamura, Tadao, additional, Mitsuo, Kunihiko, additional, Masaki Morisige, Takamitu Hikawa, additional, Takeda, Yuu, additional, Yamaguchi, Yutaka, additional, Shunro Uchinokura, Shiro Miyata, additional, Goya, Tomokazu, additional, Takeshima, Hideo, additional, Yatsushiro, Kazutaka, additional, Ohta, Hajime, additional, Nagadou, Tatsui, additional, Hirahara, Kazuho, additional, Obara, Souichi, additional, Seto, Hiroshi, additional, Moroki, Koiti, additional, Arita, Kazunori, additional, Ishiuchi, Shogo, additional, Uchihara, Toshimitsu, additional, Mekaru, Susumu, additional, Nagamine, Tomoaki, additional, Jin Momoji, Naoki Tomiyama, additional, Atusi Kimoto, Kouzi Idomari, additional, Kadekaru, Tsutomu, additional, Syamoto, Hirosi, additional, Sasaki, Osamu, additional, Minagawa, Makoto, additional, Takahashi, Hideaki, additional, Hiroyuki Arai, Kiyoshi Onda, additional, Takeuchi, Shigekazu, additional, Abe, Hiroshi, additional, Fukuda, Osamu, additional, Kouno, Mitsuo, additional, Tamura, Tetsuro, additional, Michiya Kubo, Yukio Horie, additional, Hondo, Hiroaki, additional, Takada, Hisashi, additional, Masuoka, Toru, additional, Shirasaki, Naoki, additional, Nitta, Hisashi, additional, Yasuo Katsuki, Makoto Kimura, additional, Hisato Minamide, Yutaka Hayashi, additional, Munemoto, Shigeru, additional, Ikeda, Kiyonobu, additional, Yutaka Hayashi, Mitsutoshi Nakada, additional, Sato, Syuji, additional, Hatano, Taketo, additional, Yamamura, Osamu, additional, Kabuto, Masanori, additional, Jyunya Hayashi, Takahiro Sakuma, additional, Kinouchi, Hiroyuki, additional, Koizumi, Hidehito, additional, Imae, Syougo, additional, Fujita, Manabu, additional, Suga, Masakazu, additional, Kanehisa Kohno, Shinji Iwata, additional, Zenke, Kiichiro, additional, Fujisawa, Mutsuo, additional, Mizobuchi, Hikaru, additional, Hayashi, Satoru, additional, Morimoto, Masanori, additional, Ueba, Tetsuya, additional, Nishimura, Hiroyuki, additional, Ikawa, Naoki, additional, Matsumoto, Yuzo, additional, Kannuki, Seiji, additional, Kagawa, Masahiro, additional, Hayashi, Naoki, additional, Atsushi Shindo, Takashi Tamiya, additional, Yoshino, Kimihiro, additional, Masaoka, Tetsuya, additional, Nakahara, Ichiro, additional, Satoshi Suzuki, Akira Nakamizo, additional, Okamoto, Yuji, additional, Takahashi, Haruki, additional, Hirakawa, Katsuyuki, additional, Nagata, Shinji, additional, Ookura, Akio, additional, Yoshiro Kaneko, Hidenori Yoshida, additional, Nakane, Hiroshi, additional, Inoue, Isao, additional, Hitotsumatsu, Tsutomu, additional, Kouichi Kuramoto, Terukazu Kuramoto, additional, Hiromichi Ooishi, Yoshihisa Matumoto, additional, Masani Nonaka, Tooru Inoue, additional, Morioka, Motohiro, additional, Shuji Sakata, Hiroshi Sugimori, additional, Takashima, Hiroshi, additional, Ishihara, Shin-Ichiro, additional, Suzuyama, Kenji, additional, Miyazono, Masayuki, additional, Itaro Hattori, Masafumi Morimoto, additional, Ozaki, Satoshi, additional, Hirota, Nobuo, additional, Yasuhiko Mochimatsu, Yasunori Takemoto, additional, Takagi, Makoto, additional, Kenji Nakayama, Isao Yamamoto, additional, Hiroshi Tanaka, Yoshinori Uchida, additional, Sakata, Katsumi, additional, Nobutaka, Kawahara, additional, Nomura, Motohiro, additional, Ozawa, Hitoshi, additional, Tsumura, Kotaro, additional, Michiyuki Maruyama, Makoto Inaba, additional, Mori, Tatsuro, additional, Mori, Takahisa, additional, Sugitani, Masato, additional, Tanaka, Yuichiro, additional, Yamada, Masaru, additional, Matsumae, Mitsunori, additional, Onitsuka, Keiichirou, additional, Tatsuya Takahashi, Kosuke Miyahara, additional, Endou, Sumio, additional, Takahashi, Hidekazu, additional, Kaidu, Hiroyuki, additional, Chikashi Maruki, Akira Tsunoda, additional, Fujimaki, Takamitsu, additional, Ooigawa, Hidetoshi, additional, Masatsugu Uchida, Masahiko Tanaka, additional, Kouiti Katoh, Hiroshi Wanihuti, additional, Hyodo, Akio, additional, Asakura, Ken, additional, Nakajima, Shigeyoshi, additional, Kanzawa, Takao, additional, Kurihara, Hideyuki, additional, Ohmori, Sigehiro, additional, Hiroshi Kusunoki, Mitsugi Yoshinao, additional, Magarisawa, Satoshi, additional, Okabe, Shinichi, additional, Kujiraoka, Yuuji, additional, Tsuruoka, Shin, additional, Takeshita, Mikihiko, additional, Akira Matsumura, Tetsuya Yamamoto, additional, Uemura, Kazuya, additional, Tabata, Hitoshi, additional, Sonobe, Makoto, additional, Ryoji Yoshida, Masashi Nakatsukasa, additional, Shimoeda, Norifumi, additional, Kunimine, Hideo, additional, Ishihara, Masayuki, additional, Murai, Nozomu, additional, Murakami, Nobukuni, additional, Kidooka, Minoru, additional, Iwamoto, Yoshihiro, additional, Tenjin, Hiroshi, additional, Masahiko Takamasu, Kouji Shiga, additional, Mori, Nobuhito, additional, Kose, Shigeru, additional, Kohmura, Eiji, additional, Matsumoto, Keigo, additional, Sakaki, Takayuki, additional, Miyake, Hiroji, additional, Mabuchi, Eiichiro, additional, Yokota, Masayuki, additional, Yosihiro Kuga, Hideyuki Ohnishi, additional, Kimura, Mitsuru, additional, Masaaki Saiki, Osamu Narumi, additional, Nakajima, Norio, additional, Asahi, Minoru, additional, Koyama, Junji, additional, Noda, Shinya, additional, Iida, Junichi, additional, Fujita, Toyohisa, additional, Nakase, Hiroyuki, additional, Toru Hoshida, Hidehiro Hirabayashi, additional, Fujimoto, Takayoshi, additional, Nakao, Naoyuki, additional, Tanaka, Yoshiyuki, additional, Ozaki, Fuminori, additional, Nakamura, Yoshinari, additional, Miki, Kazuhito, additional, Watanabe, Takashi, additional, Hasegawa, Seiko, additional, Konno, Hiromu, additional, Takemura, Atsuhito, additional, Okubo, Atsuya, additional, Saito, Hitoshi, additional, Taizen Nakase, Tatsuya Ishikawa, additional, Toshio Sasajima, Hiroaki Shimizu, additional, Sasou, Masayuki, additional, Watanabe, Yoichi, additional, Kiyoshi Saito, Taku Sato, additional, Masahiro Satoh, Satoshi Taira, additional, Koizumi, Takayuki, additional, Shoji Mashiyama, Yasuhiro Suzuki, additional, Oikawa, Tomoyoshi, additional, Sonoda, Yukihiko, additional, Shinjiro Saito, Rei Kondo, additional, Shinoda, Atsuo, additional, Kamatsuka, Eiichiro, additional, So, Keiten, additional, Kinjo, Toshihiko, additional, Kennji Itou, Tooru Sasaki, additional, Hiroaki Shimizu, Hidenori Endo, additional, Karibe, Hirosi, additional, Takahashi, Kou, additional, Nakajima, Masayuki, additional, Watanabe, Kazuyoshi, additional, Takayama, Motohiro, additional, Komuro, Taro, additional, Fumio Suzuki, Hisao Hirai, additional, Suzuki, Hidenori, additional, Murata, Hiroto, additional, Miya, Fumitaka, additional, Kanamaru, Kenji, additional, Tamura, Akira, additional, Harada, Kiyoshi, additional, Fukazawa, Seiji, additional, Takehara, Seiya, additional, Watanabe, Yoshihiko, additional, Nakayama, Teiji, additional, Hiroshi Nagura, Haruhiko Sato, additional, Chiharu Tanoi, Shinji Amano, additional, Kuroda, Katsuhiro, additional, Morooka, Satoru, additional, Masashi Kitagawa, Takafumi Wataya, additional, Koide, Kazuo, additional, Tanigawara, Tetsuya, additional, Iwama, Toru, additional, Ito, Junki, additional, Noda, Shinji, additional, Kouno, Kazuyuki, additional, Kitazawa, Kazuo, additional, Toshiki Takemae, Yoshikazu Kusano, additional, Hokama, Masanobu, additional, Yoshihisa Nishiyama, Hiroki Sato, additional, Seguchi, Tatsuya, additional, Yoshihiko Inui, Sumio Kobayashi, additional, Oohigashi, Youji, additional, Muraoka, Shinsuke, additional, Miyatake, Masaki, additional, Nakagawa Shinichi, Kensuke Hayashida, additional, Inoue, Atsushi, additional, Sakai, Keiichi, additional, Yamaguchi, Shuhei, additional, Fusao Ikawa, Tatsuya Mizoue, additional, Hideki Irie, Gen Ishida, additional, Kagawa, Takato, additional, Namba, Yoichiro, additional, Nakashima, Hiroyuki, additional, Koji Abe, Isao Date, additional, Uno, Masaaki, additional, Sen Yamagata, Masaki Chin, additional, Soitiro Takao, Hidemiti Sasayama, additional, Kouji Muneda, Hideyuki Yoshida, additional, Watanebe, Akira, additional, Katou, Syouichi, additional, Hamada, Yasuhiro, additional, Nishizaki, Takafumi, additional, Yamashita, Katsuhiro, additional, Ryuji Nakamura, Takaharu Nakamura, additional, Wakabayashi, Shinichi, additional, Okazaki, Takahito, additional, Kurisu, Kaoru, additional, Matsumoto, Masayasu, additional, Katsuzo Kiya, Atsushi Tominaga, additional, Syuichi Oki, Masaaki Shibukawa, additional, Nakahara, Toshinori, additional, Okita, Shinji, additional, Torii, Tuyosi, additional, Kenjirou Fujiwara, Minoru Nakagawa, additional, Syuuhei Nishimura, Takashi Matsuoka, additional, Naoyuki Isobe, Osamu Hamasaki, additional, Shinji Nagahiro, Junichiro Satomi, additional, Agawa, Masahito, additional, Oka, Hirofumi, additional, Yoshimura, Kunikazu, additional, Kato, Tsutomu, additional, Satoshi Minoshima, Nobuaki Kobayasi, additional, Mikuni, Nobuhiro, additional, Tanikawa, Rokuya, additional, Sasaki, Jyunkou, additional, Otawara, Yasunari, additional, Tominaga, Teiji, additional, Sasaki, Tatsuya, additional, Takemura, Sunao, additional, Kawakami, Masahisa, additional, Ihara, Satoshi, additional, Shibata, Yasushi, additional, Saegusa, Takashi, additional, Iuchi, Toshihiko, additional, Ito, Chiaki, additional, Okuda, Osamu, additional, Yoshida, Kazunari, additional, Masateru Katayama, Sadao Suga, additional, Akihiro, Oikawa, additional, Miura, Naohisa, additional, Ota, Takahiro, additional, Kumabe, Toshihiro, additional, Suzuki, Sachio, additional, Kumagai, Takashi, additional, Nishimaki, Keiichi, additional, Hongo, Kazuhiro, additional, Shigeta, Hiroaki, additional, Hattori, Kazuyoshi, additional, Uozumi, Yoichi, additional, Nakahara, Norimoto, additional, Hashimoto, Nobukazu, additional, Shu Imai, Shinichi Shirakami, additional, Okumura, Yoshinari, additional, Kazuhiro Yokoyama, Ryo Tamaki, additional, Miyamoto, Susumu, additional, Yamamoto, Kazuo, additional, Ichioka, Tsugumichi, additional, Inoue, Tsuyoshi, additional, Kinoshita, Manabu, additional, Saitoh, Minoru, additional, Aihara, Hideo, additional, Miyake, Hajimu, additional, Tukasa Nishiura, Kotaro Ogihara, additional, Nishino, Shigeki, additional, Miyoshi, Yasuyuki, additional, Arisawa, Tadashi, additional, Shoji Tsuchimoto, Shigeru Daido, additional, Kinoshita, Kimihisa, additional, Keisuke Migita, Kiyoshi Yuki, additional, Akatsuka, Keiichi, additional, Fujisawa, Hirosuke, additional, Shono, Tadahisa, additional, Tsugu, Hitoshi, additional, Hayashi, Shuji, additional, Toshio Matsushima, Tatsuya Abe, additional, Nakashima, Susumu, additional, Tuji, Takehisa, additional, Kaga, Akihiko, additional, Kanemaru, Reizou, additional, Takasaki, Koji, additional, Imamura, Junichi, additional, Noha, Masahiro, additional, Watanabe, Saburo, additional, Sakai, Nobuyuki, additional, Hiroaki Minami, Yasuhisa Yoshida, additional, Okumura, Tomoyoshi, additional, Nishimura, Shinjitsu, additional, Numazawa, Shinichi, additional, Masanori Tsutsumi, Kiyoshi Kazekawa, additional, Fukuyama, Kouzou, additional, and Fujimoto, Yasuhiro, additional

Published
2019
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