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36 results on '"Oyunbaatar, Nomin-Erdene"'

4. Highly durable crack sensor integrated with silicone rubber cantilever for measuring cardiac contractility in culture media

Author

Kim, Dong-Su, Choi, Yong Whan, Jeong, Yun-Jin, Park, Jongsung, Oyunbaatar, Nomin-Erdene, Kim, Eung-Sam, Choi, Mansoo, and Lee, Dong-Weon

Subjects
Physics - Applied Physics
Abstract

We propose a novel cantilever device integrated with a polydimethylsiloxane (PDMS)-encapsulated crack sensor that directly measures the cardiac contractility. The crack sensor was chemically bonded to a PDMS thin layer to form a sandwiched structure which allows to be operated very stably in culture media. The reliability of the proposed crack sensor has improved dramatically compared to no encapsulation layer. After evaluating the durability of the crack sensor bonded with the PDMS layer, cardiomyocytes were cultured on the nano-patterned cantilever for real-time measurement of cardiac contractile forces. The highly sensitive crack sensor continuously measured the cardiac contractility without changing its gauge factor for up to 26 days (>5 million heartbeats). In addition, changes in contractile force induced by drugs were monitored using the crack sensor-integrated cantilever. Finally, experimental results were compared with those obtained via conventional electrophysiological methods to verify the feasibility of building a contraction-based drug-toxicity testing system.

Published
2019
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13. The PolyCraft Polymer–Metal Hybrid Smart Stent System: The Future of Cardiovascular Blood Pressure Management.

Author

Wang, Lei, Oyunbaatar, Nomin‐Erdene, Jeong, Yun‐Jin, Lee, Heonzoo, Won, Yonggwan, Jeong, In‐Seok, Kayumov, Mukhammad, Obiweluozor, Francis O., Kim, Dong‐Su, and Lee, Dong‐Weon

Subjects
*BLOOD substitutes, *LASER machining, *POLYLACTIC acid, *ANIMAL experimentation, *BLOOD vessels
Abstract

To address the complication of in‐stent restenosis that occurs with traditional stent treatments, this study proposes an innovative hybrid smart stent‐based medical system. This approach allows to overcome the limitations of existing bare metal or polymer‐based smart stents, which interfere with radio frequency signals, less deformability, or do not provide adequate radial support, respectively. The proposed hybrid stent, which uses a Co/Cr–polycaprolactone (PCL)–Co/Cr configuration connected by a unique dual inverted Y‐type connector for metal–polymer integration is integrated with a LC wireless pressure sensor fabricated through a semiconductor process. The fabricated hybrid stent made by laser machining and custom‐made 3D printing, offers excellent properties such as radial strength (0.125 N/mm) and flexibility (2 N mm2) and provides intravascular information to the outside through the integrated sensor without signal degradation. After basic experiments using a phantom, animal experiments are conducted by combining the fabricated sensor with artificial blood vessel, and the results measured by the external antenna system are consistent with the results of a commercial reference sensor. The proposed wireless sensor‐based smart stents and artificial blood vessels aim to gather diverse patient health data for integration with artificial intelligence, laying the groundwork for next‐generation medical innovation. [ABSTRACT FROM AUTHOR]

Published
2024
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