43 results on '"Oyarzábal, Julen"'
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2. Omipalisib inspired macrocycles as dual PI3K/mTOR inhibitors
3. A novel FTY720 analogue targets SET-PP2A interaction and inhibits growth of acute myeloid leukemia cells without inducing cardiac toxicity
4. Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors
5. Impact of Neurodegenerative Diseases on Drug Binding to Brain Tissues: From Animal Models to Human Samples
6. Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease
7. Targeting CB1 and GPR55 Endocannabinoid Receptors as a Potential Neuroprotective Approach for Parkinson’s Disease
8. GPR55: A therapeutic target for Parkinson's disease?
9. Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson’s disease
10. In Silico Aptamer Docking Studies: From a Retrospective Validation to a Prospective Case Study'TIM3 Aptamers Binding
11. The monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model
12. Tadalafil crosses the blood–brain barrier and reverses cognitive dysfunction in a mouse model of AD
13. Corrigendum to
14. In vivo, in vitro and in silico methods for small molecule transfer across the BBB
15. Chemical Interrogation of FOXO3a Nuclear Translocation Identifies Potent and Selective Inhibitors of Phosphoinositide 3-Kinases
16. Dual Targeting of G9a and DNA Methyltransferase‐1 for the Treatment of Experimental Cholangiocarcinoma
17. Mechanism and structure–activity relationships of norspermidine-based peptidic inhibitors of trypanothione reductase
18. Synthesis of novel 2,5-dihydro-1,5,2-diazaphosphinines from primary enamine phosphonates and from alkyl phosphonates
19. OS165 - The inhibition of the epigenetic efectors DNMT1 and G9a as a potential therapeutic strategy against the non-alcoholic fatty liver development
20. The AhpC and AhpD Antioxidant Defense System of Mycobacterium tuberculosis
21. Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria
22. A simple synthesis of 3-phosphonyl-4-aminoquinolines from β-enaminophosphonates
23. An easy strategy for the synthesis of 5-phosphorylated pyrimidin-2,4-diones from β-phosphine oxide and phosphonate enamines
24. A new and efficient strategy for the preparation of 1,5,2-diazaphosphorines from primary β-enaminophosphonates
25. FRI245 - Epigenetic mechanism and metabolic reprogramming in fibrogenesis: dual targeting of G9a and DNA methyltransferase 1 for the inhibition of liver fibrosis
26. AS022 - Dual inhibition of DNA methyltransferase 1 and the histone methyltransferase G9a as a new therapeutic strategy in hepatoblastoma
27. Targeting CB1 and GPR55 Endocannabinoid Receptors as a Potential Neuroprotective Approach for Parkinson's Disease.
28. Differentiation Therapy with Novel Epigenetic Inhibitors in Acute Myeloid Leukemia
29. THU-064-Identification of new epigenetic targets in hepatic fibrosis
30. PS-043-Dual targeting of G9a and DNM-methyltransferase-1 for the treatment of experimental cholangiocarcinoma
31. Rapid identification of ETP-46992, orally bioavailable PI3K inhibitor, selective versus mTOR
32. Identification of ETP-46321, a potent and orally bioavailable PI3K α, δ inhibitor
33. Imidazo[1,2-a]pyrazines as novel PI3K inhibitors
34. Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors
35. Inhibition of FOXP3/NFAT interaction enhances T cell function after TCR stimulation
36. The CHEMDNER corpus of chemicals and drugs and its annotation principles
37. Inhibition of FOXP3/NFAT interaction enhances T cell function after TCR stimulation
38. Inhibition of FOXP3/NFAT Interaction Enhances T Cell Function after TCR Stimulation
39. Phosphodiesterases as Therapeutic Targets for Alzheimer's Disease
40. Discovery of 1,5-Disubstituted Pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor
41. Inhibition of the Methyltransferase G9a with Small Molecules As a New Therapeutic Strategy for Treatment of Hematological Malignancies
42. A “one pot” synthesis of polysubstituted pyridines from metallated alkylphosphonates, nitriles and α,β-unsaturated ketones
43. A simple and efficient strategy for the preparation of 5-phosphorylated imidazol-2-ones from primary β-enaminophosphonates
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