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18 results on '"Oxley, Jon D."'

10. Serine-arginine protein kinase 1 (SRPK1), a determinant of angiogenesis, is upregulated in prostate cancer and correlates with disease stage and invasion

Author

Bullock, Nicholas, Potts, Jonathan R, Simpkin, Andrew J, Koupparis, Anthony J, Harper, Steven J, Oxley, Jon D, and Oltean, Sebastian

Subjects
Adult, Male, Short Report, Protein Serine-Threonine Kinases, Risk Assessment, ANGIOGENESIS, Predictive Value of Tests, Risk Factors, Biomarkers, Tumor, Tumor Microenvironment, PROSTATE, Humans, Neoplasm Invasiveness, Angiogenic Proteins, Aged, Neoplasm Staging, Prostatectomy, Prostatic Neoplasms, Middle Aged, CANCER, Immunohistochemistry, Up-Regulation, Treatment Outcome, Neoplasm Recurrence, Local
Abstract

Vascular endothelial growth factor (VEGF) undergoes alternative splicing to produce both proangiogenic and antiangiogenic isoforms. Preferential splicing of proangiogenic VEGF is determined by serine-arginine protein kinase 1 (SRPK1), which is upregulated in a number of cancers. In the present study, we aimed to investigate SRPK1 expression in prostate cancer (PCa) and its association with cancer progression. SRPK1 expression was assessed using immunohistochemistry of PCa tissue extracted from radical prostatectomy specimens of 110 patients. SRPK1 expression was significantly higher in tumour compared with benign tissue (p

Published
2015

13. Characteristics of men responding to an invitation to undergo testing for prostate cancer as part of a randomised trial

Author

Walsh, Eleanor I., Turner, Emma L., Lane, J. Athene, Donovan, Jenny L., Neal, David E., Hamdy, Freddie C., Martin, Richard M., Metcalfe, Chris, Sterne, Jonathan, Noble, Sian, Hill, Elizabeth, Ng, Siaw Yein, Williams, Naomi J, Down, Elizabeth A, Walsh, Eleanor, Thorn, Joanna, Davies, Charlotte, Hughes, Laura, Rowlands, Mari Anne, Bell, Lindsey, Ben-Shlomo, Yoav, Oliver, Steven E, Brindle, Peter, Evans, Simon, Baum, Michael, Albertsen, Peter, Roberts, Tracy, Robinson, Mary, Adolfsson, Jan, Dearnaley, David, Zeitman, Anthony, Schröder, Fritz, Peters, Tim, Holding, Peter, Lennon, Teresa, Bonnington, Sue, Mason, Malcolm, Oxley, Jon D, Holmberg, Lars, Pickard, Robert, Thompson, Simon, Menon, Usha, Reid, Colette, McFarlane, Jon, Bahl, Amit, Koupparis, Anthony, Tazewell, Marta, and Hatton-Brown, Genevieve

Subjects
Randomised controlled trial, Prostate cancer, Prostate specific antigen testing, Centre for Surgical Research, Screening, BRTC, BTC (Bristol Trials Centre), PSA testing
Abstract

BackgroundSocio-demographic characteristics are associated with participating in cancer screening and trials. We compared the characteristics of those responding with those not responding to a single invitation for PSA testing for prostate cancer as part of the Cluster randomised triAl of PSA testing for Prostate cancer (CAP).MethodsAge, rurality and deprivation among 197,763 men from 271 cluster-randomised primary care centres in the UK were compared between those responding (n=90,300) and not responding (n=100,953) to a prostate cancer testing invitation.Results There was little difference in age between responders and non-responders. Responders were slightly more likely to come from urban rather than rural areas and were slightly less deprived than those who did not respond. ConclusionThese data indicate similarities in age and only minor differences in deprivation and urban location between responders and non-responders. These differences were smaller, but in the same direction as observed in other screening trials.

Published
2016

18. Lichenoid and granulomatous stomatitis: an entity or a non-specific inflammatory process?

Author

Robinson CM, Oxley JD, Weir J, and Eveson JW

Subjects
Adrenergic beta-Antagonists adverse effects, Aged, Angiotensin-Converting Enzyme Inhibitors adverse effects, Anti-Inflammatory Agents, Non-Steroidal adverse effects, Atenolol adverse effects, Drug Combinations, Drug Eruptions pathology, Drug Hypersensitivity complications, Female, Granuloma pathology, Humans, Lichen Planus, Oral pathology, Male, Middle Aged, Mouth Mucosa pathology, Naproxen adverse effects, Ramipril adverse effects, Stomatitis etiology, Stomatitis classification, Stomatitis pathology
Abstract

Background: The presence of lichenoid or granulomatous inflammation in an oral mucosal biopsy usually suggests a distinct range of diagnostic possibilities. However, the presence of both patterns of inflammation in the same biopsy is uncommon., Methods: A clinico-pathological study of six patients., Results: All the patients in this study presented with similar mucosal lesions of the upper lip. Microscopically the lesions were characterized by the presence of lichenoid inflammation with concomitant granulomatous inflammation. The lesions were persistent and refractory to treatment with steroid medications, but remained localized and did not appear to herald the onset of systemic inflammatory or neoplastic disease., Conclusion: We propose the designation 'lichenoid and granulomatous stomatitis' for the cases described in this study. The clinico-pathological features of a subset of these cases suggest an unusual drug eruption.

Published
2006
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