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Transdermal drug delivery offers a promising alternative to traditional methods such as oral ingestion and hypodermic injection. Hypodermic injections are painful, while oral ingestion requires higher doses due to enzymatic degradation and poor absorption. While microneedles address the pain issue, they are limited to delivering small amounts of drugs and can be impractical due to peeling off with motion and sweat. Herein, this work proposes soft injectables using drug-carrying sutures for painless and localized sustained delivery in the dermis. These sutures can remain in place during delivery and are suitable for all skin types. Surgical sutures can also serve as open capillary microfluidic channels carrying drug from a wearable drug reservoir to enable long-term (weeks to months) transdermal drug delivery. The experiments focus on delivering 5-fluorouracil (5-FU), a cancer drug, and rhodamine B, a drug model. A fixed-length suture of 60 cm delivers 0.43 mg of 5-flurouracil in 15 min. The experiments also demonstrate a continuous drug delivery of rhodamine B for over 8 weeks at a rate of 0.0195 mL h -1 . The results highlight that soft injectable sutures are promising candidates for long-term sustained delivery of varying quantities of drugs over weeks period compared to hypodermic injection, oral ingestion, or microneedles., (© 2023 Wiley-VCH GmbH.)

There is a need for flexible chemical sensors for the ecological and physiological research of avian species such as house sparrows ( Passer domesticus ). Current methods in this field are invasive and require multiple physical interactions with the birds. Emerging research in flexible bioelectronics can enable realization of implantable devices that are mechanically compliant with the underlying tissues for continuous real-time sensing in situ . However, challenges still remain in forming an intimate flexible interface. One of the promising flexible bioelectronic platforms for tissue-embedded sensing is based on functionalizing surgical sutures or threads. Threads have three-dimensional flexibility, high surface-area-to-volume ratio, inherent wicking properties, and are easily functionalizable using reel-to-reel dip coating. Threads are ideal as they are lightweight, therefore, would not interfere with flight motion and would only require minimal interaction with the bird. However, the challenge remains in achieving a highly conductive yet flexible electrode for electrochemical sensing using materials such as gold. In this study, we address this issue through novel gold deposition directly on thread substrate followed by enzyme immobilization to realize flexible electrochemical glucose biosensors on medical-grade sutures. These sensors were calibrated and tested in a range that is wide enough to include the expected range of glucose concentration in house sparrows (0-8.55 mM). Glucose monitoring in house sparrows will provide insights into energy metabolism and regulation during stress responses. In addition, the stability, repeatability, and selectivity of the sensor were tested with final validation in a real bird. Our innovative gold-coated, thread-based flexible electrochemical glucose sensor can also be used in other small and large animals. This can also be extended to monitoring other metabolites in future.

Deep eutectic solvent (DES) gel electrolytes have recently emerged as promising alternatives to ionic liquid- or water-based gels for "ionic skin" sensor applications. Researchers have also been exploring the effects that varying amounts of water may have on the local hydrogen bonding environment within a few model DES systems. In this study, the physical properties and ionic conductivities of biopolymer (gelatin)-supported gels featuring two established DESs and three DES/water mixture formulations are investigated and compared. The DES/water mixtures are formed by combining choline chloride with one of three organic hydrogen bond donors (HBDs), ethylene glycol, glycerol, or 1,2-propanediol, in a 1:2 molar ratio, together with a controlled amount of water, 25 mol % (approximately 5-6 wt % water). For the same fixed gelatin content (20 wt %), DES/water mixture gel Young's modulus values are found to be tunable based on the organic HBD identity, increasing 6-fold from 7 (1,2-propanediol) to 42 (glycerol) kPa. Furthermore, large differences are observed in the resulting gel properties when water has been intentionally added to well-studied DESs. Coformulation with water is found to increase ethylene glycol-based DES gel toughness, measured via tensile testing, from 23 to 68 kJ/m 3 while simultaneously boosting gel room temperature ionic conductivity from 3.3 to 5.2 mS/cm. These results highlight the multiple roles that controlled amounts of water in DES can play within gelatin-supported DES/mixture gel electrolytes, such as influencing gelatin self-assembly and reducing local viscosity to promote facile ion transport.

Physically intimate, real-time monitoring of human biomarkers is becoming increasingly important to modern medicine and patient wellness. Such monitoring is possible due to advances in soft and flexible materials, devices and bioelectronics systems. Compared to other flexible platforms, multifilament textile fibers or threads offer superior flexibility, material diversity, and simple ambient processing to realize a wide range of flexible devices such as sensors, electronics, and microfluidics. In this paper, we realize unique flexible transistors on threads and interconnect them to realize logic gates and small-scale integrated circuits. Compared to prior textile-based transistors, the proposed thread-based transistors (TBTs) are realized with a readily shaped, colloidally dispersed gel consisting of silica nanoparticles and 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (EMI TFSI) ionic liquid for all-around electrolyte gating of a carbon nanotube (CNT) semiconducting network assembled on the thread. We interconnect TBTs with thread-based electrochemical sensors (TBEs) to realize an all-thread based multiplexed diagnostic device. All-thread based platforms are thin, highly flexible and conformal, allowing them to be worn directly on the skin without any polymeric substrate, or sutured transdermally using a needle.

Three-dimensional printers have revolutionized many scientific fields with its low-cost, accessibility and ease of printing. In this paper, we show how stereolithography (SLA) based 3D printers can enable realization of innovative 3D optical devices formed through the fusion of metamaterials with geometrical optics or MEGO. It utilizes a combination of desktop SLA 3D printer and metal deposition/coating systems. Using this approach, we present innovative metamaterial embedded optical components such as mushroom-type metamaterials, curved wide-angle metamaterial absorbers/reflectors and a frequency selective moth eye hemispherical absorber. Finally a unique MEGO device formed through the fusion of a frequency selective metamaterial with an optical parabolic reflector has been demonstrated that combines their individual properties in a single device. The fabricated MEGO devices operate in the millimeter wave frequency range. Simulation and measurement results using terahertz continuous-wave spectrometer validate their functionality and performance. With improving resolution in 3D printing, MEGO devices will be able to reach Terahertz and optical frequencies in the near future., Competing Interests: The authors declare that they have no conflict of interest.

A fabrication method for a stable entrapment of optically responsive dyes on a thread substrate is proposed to move towards a detection system that can be integrated into clothing. We use the dyes 5,10,15,20-Tetraphenyl-21H,23H-porphine manganese(III) chloride (MnTPP), methyl red (MR), and bromothymol blue (BTB), for a proof-of-concept. Our optical approach utilizes a smartphone to extract and track changes in the red (R), green (G) and blue (B) channel of the acquired images of the thread to detect the presence of an analyte. We demonstrate sensing of 50-1000 ppm of vapors of ammonia and hydrogen chloride, components commonly found in cleaning supplies, fertilizer, and the production of materials, as well as dissolved gas sensing of ammonia. The devices are shown to be stable over time and with agitation in a centrifuge. This is attributed to the unique dual step fabrication process that entraps the dye in a stable manner. The facile fabrication of colorimetric gas sensing washable threads is ideal for the next generation of smart textile and intelligent clothing.

In this work, a paper-based optoelectronic sensor (paper-nose) is presented for sensing volatile gases in air. The proposed optoelectronic sensor is a combination of both colorimetric (optical) and chemiresistive (electronic) sensor arrays in order to improve the selectivity of the paper-nose in the complex air background. The optical sensors are based on chemoresponsive dyes, namely Reichardt's dye (2,6-diphenyl-4-(2,4,6-triphenyl-1-pyridinio)phenolate), bromocresol purple, methyl red, bromothymol blue, brilliant yellow and manganese tetraphenylporphyrin (Mn-TPP). The chemiresistive sensors are based on nanomaterials, such as carbon nanotubes (CNT), PEDOT:PSS, graphite, and an ionic liquid, 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (EMI TFSI). Sensor is fabricated through direct handwriting of sensing materials using a pen on paper without the need of expensive cleanroom facilities. The optoelectronic sensor is tested in ambient air with different volatile gases such as methanol, ammonia, toluene, acetone and ethanol and their mixtures of varying concentrations. The detected electrical and optical responses together form a unique signature for each volatile gas and its mixture. Support-vector machine (SVM) is applied for target classification and detection. From the SVM result, it is found that better discriminative power is achieved by combining optical and electrical responses., (Copyright © 2018 Elsevier B.V. All rights reserved.)