178 results on '"Owen, Dafydd R."'
Search Results
2. A data science roadmap for open science organizations engaged in early-stage drug discovery
3. A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19
4. Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex
5. Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3
6. Chemical Tools for the Gid4 Subunit of the Human E3 Ligase C-terminal to LisH (CTLH) Degradation Complex
7. The promise and peril of chemical probes
8. Supplementary Methods, Figure Legends from The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies
9. Supplementary Figures 1 - 8 from The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies
10. Data from The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies
11. Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complexElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3md00633f
12. A chemical probe to modulate human GID4 Pro/N-degron interactions
13. Target 2035 – an update on private sector contributions
14. Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4
15. Epigenetic drugs that do not target enzyme activity
16. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells
17. Target 2035 – update on the quest for a probe for every protein
18. An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19
19. An Oral SARS-CoV-2 Mpro Inhibitor Clinical Candidate for the Treatment of COVID-19
20. Structure and inhibitor binding characterization of oncogenic MLLT1 mutants
21. The Kinase Chemogenomic Set (KCGS): an open science resource for kinase vulnerability identification
22. Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4
23. Target 2035 – an update on private sector contributions
24. Investigating 3,3-Diaryloxetanes as Potential Bioisosteres in Drug Discovery
25. Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants
26. Investigating 3,3-diaryloxetanes as potential bioisosteres through matched molecular pair analysis
27. 1-oxaspiro[4.4]nonan-6-ones. Synthetic access via oxonium ion technology, optical resolution, and conversion into enantiopure spirocyclic alpha,beta-butenolides
28. Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases
29. An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
30. The Kinase Chemogenomic Set (KCGS): An open science resource for kinase vulnerability identification
31. Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3–9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase
32. Design and identification of a novel, functionally subtype selective GABAApositive allosteric modulator (PF-06372865).
33. Target 2035 – update on the quest for a probe for every protein
34. Donated chemical probes for open science
35. Author response: Donated chemical probes for open science
36. Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance
37. Investigating 3,3-diaryloxetanes as potential bioisosteres through matched molecular pair analysisElectronic supplementary information (ESI) available: Spectroscopic data of synthesized compounds, and experimental procedures for ADME data, and table of log Ddata. See DOI: 10.1039/d1md00248a
38. Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation
39. Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies
40. Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3–9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase
41. Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit
42. SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling
43. Erratum: Corrigendum: The promise and peril of chemical probes
44. Lysine Methyltransferase SETD7 (SET7/9) Regulates ROS Signaling through mitochondria and NFE2L2/ARE pathway
45. The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies
46. Optimisation of a novel series of selective CNS penetrant CB 2 agonists
47. Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors
48. Abstract 2105: Regulation of estrogen receptor turnover by lysine 302 methylation
49. Toward a New Generation of PDE5 Inhibitors through Advances in Medicinal Chemistry
50. Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.