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2. Effectiveness and persistence of acitretin, ciclosporin, fumaric acid esters and methotrexate for patients with moderate-to-severe psoriasis:a cohort study from BADBIR

Author

Alabas, Oras A, Mason, Kaleigh J, Yiu, Zenas Z N, Hampton, Philip J, Reynolds, Nick J, Owen, Caroline M, Bewley, Anthony, Laws, Philip M, Warren, Richard B, Lunt, Mark, Smith, Catherine H, and Griffiths, Christopher E M

Subjects
Dermatology
Abstract

Background Real-world data evaluating effectiveness and persistence of systemic therapies for patients with psoriasis are limited. Objectives To determine the effectiveness and persistence of acitretin, ciclosporin, fumaric acid esters (FAEs) and methotrexate in patients with moderate-to-severe psoriasis. Methods Data from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR), a prospective, multicentre pharmacovigilance register of patients with moderate-to-severe psoriasis receiving biologic and/or conventional systemic therapies, were analysed. Eligible patients were ≥ 16 years of age receiving a first course of acitretin, ciclosporin, FAEs or methotrexate between 2007 and 2021 with ≥ 6 months’ follow-up. Effectiveness was defined as achieving absolute Psoriasis Area and Severity Index (aPASI) ≤ 2 reported ≥ 4 weeks after treatment start date until date of cessation. To identify baseline clinical variables associated with treatment effectiveness, we used multivariable logistic regression models estimating the adjusted odds ratio (aOR) of achieving aPASI ≤ 2. To describe drug persistence associated with ineffectiveness, occurrence of adverse events or other reasons for discontinuation, survival estimates with 95% confidence intervals (CIs) were obtained using a flexible parametric model. Results were obtained using multiple imputed data. Results In total, 5430 patients were included in the analysis. Overall, 1023 (19%) patients were receiving acitretin, 1401 (26%) patients were on ciclosporin, 347 (6%) patients were on FAEs, and 2659 (49%) patients were receiving methotrexate at registration. The proportion of patients who achieved aPASI ≤ 2 was lower for those treated with acitretin [n = 118 (21%)] compared with those receiving ciclosporin [n = 233 (34%)], FAEs [n = 43 (29%)] and methotrexate [n = 372 (32%)]. Factors associated with ineffectiveness included prior experience to previous nonbiologic systemic therapies (acitretin) (aOR 0.64, 95% CI 0.42–0.96), male sex (methotrexate) (aOR 0.58, 95% CI 0.46–0.74), comorbidities (aOR 0.70, 95% CI 0.51–0.97) and alcohol consumption (≤ 14 units per week) (ciclosporin) (aOR 0.70, 95% CI 0.50–0.98). Persistence associated with all reasons for discontinuation showed better survival for methotrexate compared with acitretin, ciclosporin and FAEs cohorts at 12 months [survival estimate 46.1 (95% CI 44.0–48.3), 31.9 (95% CI 29.4–34.7), 30.0 (95% CI 27.5–32.4) and 35.0 (95% CI 29.9–40.9), respectively]. Conclusions The real-world effectiveness and persistence of acitretin, ciclosporin, FAEs and methotrexate were generally low. Previous nonbiologic systemic therapies, male sex, comorbidities and alcohol consumption were risk factors associated with treatment ineffectiveness.

Published
2023

3. Effectiveness and persistence of acitretin, ciclosporin, fumaric acid esters and methotrexate for patients with moderate-to-severe psoriasis: a cohort study from BADBIR

Author

Alabas, Oras A, primary, Mason, Kaleigh J, additional, Yiu, Zenas Z N, additional, Hampton, Philip J, additional, Reynolds, Nick J, additional, Owen, Caroline M, additional, Bewley, Anthony, additional, Laws, Philip M, additional, Warren, Richard B, additional, Lunt, Mark, additional, Smith, Catherine H, additional, and Griffiths, Christopher E M, additional

Published
2023
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4. British Association of Dermatologists guidelines for biologic therapy for psoriasis 2023: a pragmatic update.

Author

Smith, Catherine H, Yiu, Zenas Z N, Bale, Tracy, Burden, A David, Coates, Laura C, Eckert, Elizabeth, Longley, Nicky, Mahil, Satveer K, McGuire, Arlene, Murphy, Ruth, Nelson-Piercy, Catherine, Owen, Caroline M, Parslew, Richard, Woolf, Richard T, Kiaee, Zahra Mansour, Constantin, Alina M, Ezejimofor, Martinsixtus C, Exton, Lesley S, and Mustapa, M Firouz Mohd

Subjects
BIOTHERAPY, PSORIASIS, DERMATOLOGISTS, HEART failure, YOUNG adults
Abstract

The British Association of Dermatologists (BAD) has updated its clinical guideline for biologic therapy for psoriasis, including new treatments approved since the previous version. The guideline will now be a living guideline, updated as new evidence emerges. The decision aid for clinicians and patients has also been updated. The document provides information on different biologic treatments for psoriatic arthritis, including medication details, dosing frequency, approval dates, success rates, and potential side effects. It emphasizes that some treatments are recommended only after other options have failed and not all treatments are approved for psoriatic arthritis. The document is based on real-world data and aims to support clinical practice. [Extracted from the article]

Published
2024
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7. Development of a continuous respiration olfactometer for odorant delivery synchronous with natural respiration during recordings of brain electrical activity

Author

Owen, Caroline M., Patterson, John, and Simpson, David G.

Subjects
Olfactometry -- Equipment and supplies, Brain -- Electric properties, Respiration -- Measurement, Medical geography -- Methods, Biological sciences, Business, Computers, Health care industry
Abstract

The continuous respiration olfactometer (CRO) was designed as a respiration-synchronous method for derivering odorants during recordings of brain electrical activity, providing control and monitoring of the timing of the delivery as well as the quantities of odorant involved. The CRO incorporates a purpose-built electronic system designed with very specific temporal and quantitative chracteristics, and is composed of four main parts: the respiratory monitoring apparatus, the odorant/air delivery system, the serial interface device and the respiratory monitoring software. Tests were undertaken to determine the performance of the system with reference to the accuracy and precision of timing and control of odorant delivery. Tests were also undertaken to determine the effects of variations in natural respiration between subjects on the capability of the respiratory monitoring system, using a group Of 50 Subjects, to test the success of a variable gain control to optimize the range of the digitized respiratory output. The delivery system wits able to provide information concerning quantities of air or odorant delivered, and the stimulus timing information required for integration with neurophysiological recording techniques. Index Terms--Brain topography, delivery apparatus, olfactometry, olfactory, respiratory monitoring.

Published
2002

9. Development and validation of a multivariable risk prediction model for serious infection in patients with psoriasis receiving systemic therapy

Author

Yiu, Z. Z. N., Sorbe, C., Lunt, M., Rustenbach, S. J., Kuehl, L., Augustin, M., Mason, K. J., Ashcroft, D. M., Griffiths, C. E. M., Warren, R. B., Ormerod, Anthony D., Barker, Jonathan N. W. N., Evans, Lan, McElhone, Kathleen, Smith, Catherine H., Reynolds, Nick J., Murphy, Ruth, Benham, Marilyn, Burden, A. David, Hussain, Sagair, Kirby, Brims, Lawson, Linda, and Owen, Caroline M.

Abstract

BackgroundPatients with psoriasis are often concerned about the risk of serious infection associated with systemic psoriasis treatments.ObjectivesTo develop and externally validate a prediction model for serious infection in patients with psoriasis within 1 year of starting systemic therapies.MethodsThe risk prediction model was developed using the British Association of Dermatologists Biologic Interventions Register (BADBIR), and the German Psoriasis Registry PsoBest was used as the validation dataset. Model discrimination and calibration were assessed internally and externally using the C‐statistic, the calibration slope and the calibration in the large.ResultsOverall 175 (1·7%) out of 10 033 participants from BADBIR and 41 (1·7%) out of 2423 participants from PsoBest developed a serious infection within 1 year of therapy initiation. Selected predictors in a multiple logistic regression model included nine baseline covariates, and starting infliximab was the strongest predictor. Evaluation of model performance showed a bootstrap optimism‐corrected C‐statistic of 0·64 [95% confidence interval (CI) 0·60–0·69], calibration in the large of 0·02 (95% CI −0·14 to 0·17) and a calibration slope of 0·88 (95% CI 0·70–1·07), while external validation performance was poor, with C‐statistic 0·52 (95% CI 0·42–0·62), calibration in the large 0·06 (95% CI −0·25 to 0·37) and calibration slope 0·36 (95% CI −0·24 to 0·97).ConclusionsWe present the first results of the development of a multivariable prediction model. This model may help patients and dermatologists in the U.K. and the Republic of Ireland to identify modifiable risk factors and inform therapy choice in a shared decision‐making process.

Published
2019

22. Quantitative Evaluation of Biologic Therapy Options for Psoriasis:A Systematic Review and Network Meta-Analysis

Author

Jabbar-Lopez, Zarif K., Yiu, Zenas Z.N., Ward, Victoria, Exton, Lesley S., Mohd Mustapa, M. Firouz, Samarasekera, Eleanor, Burden, A. David, Murphy, Ruth, Owen, Caroline M., Parslew, Richard, Venning, Vanessa, Warren, Richard B., and Smith, Catherine H.

Subjects
CI, confidence interval, SUCRA, surface under the cumulative ranking curve, Biological Therapy, DLQI, dermatology life quality index, PASI, psoriasis area and severity index, Clinical Research, NMA, network meta-analysis, Network Meta-Analysis, Journal Article, Humans, Psoriasis, Original Article, RCT, randomized controlled trial
Abstract

Multiple biologic treatments are licensed for psoriasis. The lack of head-to-head randomized controlled trials makes choosing between them difficult for patients, clinicians, and guideline developers. To establish their relative efficacy and tolerability, we searched MEDLINE, PubMed, Embase, and Cochrane for randomized controlled trials of licensed biologic treatments for skin psoriasis. We performed a network meta-analysis to identify direct and indirect evidence comparing biologics with one another, methotrexate, or placebo. We combined this with hierarchical cluster analysis to consider multiple outcomes related to efficacy and tolerability in combination for each treatment. Study quality, heterogeneity, and inconsistency were evaluated. Direct comparisons from 41 randomized controlled trials (20,561 participants) were included. All included biologics were efficacious compared with placebo or methotrexate at 3–4 months. Overall, cluster analysis showed adalimumab, secukinumab, and ustekinumab were comparable in terms of high efficacy and tolerability. Ixekizumab and infliximab were differentiated by very high efficacy but poorer tolerability. The lack of longer term controlled data limited our analysis to short-term outcomes. Trial performance may not equate to real-world performance, and so results need to be considered alongside real-world, long-term safety and effectiveness data. These data suggest that it is possible to discriminate between biologics to inform clinical practice and decision making (PROSPERO 2015:CRD42015017538).

Published
2017

25. Patterns of biological therapy use in the management of psoriasis:cohort study from the British Association of Dermatologists’ Biologic Interventions Register

Author

Iskandar, Ireny, Warren, Richard, Evans, Ian, Mcelhone, Kathleen, Owen, Caroline M., Burden, A David, Smith, Catherine, Reynolds, Nick J, Ashcroft, Darren, and Griffiths, CEM

Abstract

Treatment modifications, including dose escalations and reductions, switches, discontinuations and restarts of biological therapies, are often necessary and important in the ‘real-world’ management of moderate-to-severe psoriasis. We examined the treatment utilization patterns of adalimumab,etanercept and ustekinumab among biologics-naive and non-naive patients with psoriasis enrolled in the British Association of Dermatologists’ Biologic Interventions Register (BADBIR).We also assessed the patterns of use of conventional systemic therapies in combination with biological therapies in BADBIR. The cohort study included adults with chronic plaque psoriasis who were registered with BADBIR and followed up for at least 12 months. Treatment modifications were assessed during the first year of therapy. The time–trend method, comparing the annual cumulative dose the patients received with the annual recommended cumulative dose per product prescribing information based on the National Institute for Health and Care Excellence guidelines, was used to assess dosing patterns.Bridging therapy was defined as conventional systemic therapies co-prescribed during the induction of the biological therapy (≤ 120 days), while rescue therapy was defined as additional medication required following the induction phase(> 120 days). In total, 2980 patients with a mean age of 45.9 years were included, of whom, 79.2% were biologic naive. Data for patients on adalimumab (n = 1675), etanercept (n = 996) and ustekinumab (n = 309) were available. Over 12 months, 77.4% of patients continued with the biological therapy, 2.6% restarted therapy after a break of at least 90 days, 2.5% discontinued and 17.5% switched to an alter-native biological therapy. Most patients (85.7%) received there commended cumulative dose of the biological therapy,6.2% were exposed to a lower cumulative dose and 8.1%were exposed to a higher cumulative dose. Specifically, 4.5%,11.4% and 17.7% of adalimumab, etanercept and ustekinumab patients (P < 0.01), respectively, were exposed to a higher cumulative dose. A total of 749 (25.1%) patients used conventional systemic therapies in combination with biological therapy at some stage; methotrexate was the most commonly co-prescribed therapy (n = 458; 61.2%). Of those using combination therapy, 454 (60.6%) continued the use of the conventional systemic therapy for > 120 days after the start of the biological therapy, whereas 160 (21.4%) and 152(20.3%) used the conventional systemic therapy as bridging and rescue therapy, respectively. In summary, one-fifth of patients starting biological therapy in BADBIR experienced treatment modifications within the first year. Modifications included dose escalations and reductions; restarting treatment after a break; and discontinuing or switching to an alternative biological therapy. Conventional systemic therapies, particularly methotrexate, are commonly used concurrently with bio-logical therapies; this should be considered when evaluating treatment response and adverse events.

Published
2016

28. Risk of Serious Infections in Patients with Psoriasis on Biologic Therapies: A Systematic Review and Meta-Analysis

Author

Yiu, Zenas Z.N., primary, Exton, Lesley S., additional, Jabbar-Lopez, Zarif, additional, Mohd Mustapa, M. Firouz, additional, Samarasekera, Eleanor J., additional, Burden, A. David, additional, Murphy, Ruth, additional, Owen, Caroline M., additional, Parslew, Richard, additional, Venning, Vanessa, additional, Ashcroft, Darren M., additional, Griffiths, Christopher E.M., additional, Smith, Catherine H., additional, and Warren, Richard B., additional

Published
2016
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29. Differential Drug Survival of Biologic Therapies for the Treatment of Psoriasis: A Prospective Observational Cohort Study from the British Association of Dermatologists Biologic Interventions Register (BADBIR)

Author

Warren, Richard B., primary, Smith, Catherine H., additional, Yiu, Zenas Z.N., additional, Ashcroft, Darren M., additional, Barker, Jonathan N.W.N., additional, Burden, A. David, additional, Lunt, Mark, additional, McElhone, Kathleen, additional, Ormerod, Anthony D., additional, Owen, Caroline M., additional, Reynolds, Nick J., additional, and Griffiths, Christopher E.M., additional

Published
2015
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30. Treatment of Skin Disease Previous Edition Contributors

Author

Abrouk, Michael, Accordino, Robert E., Admani, Shehla, Adriaans, Beverly, Agarwal, Sanjay, Ahad, Tashmeeta, Ahmed, Imtiaz, Akhavan, Arash, Al Quran, Hanadi Abdallah, Albert, Sandra, Alberta-Wszolek, Lauren, Allen, Caroline, Allen, Robert A., Al-Qari, Haltham, Al-Suwaidan, Sami, Alwan, Wisam, Amini, Sadegh, Angit, Caroline, Anhalt, Grant J., Anyanwu, Cynthia O., Aouthmany, Mouhammad, Asch, Sarah, Ashourian, Neda, Ashton, Richard, Aslam, Arif M., Bader, Eanas, Bain, E. Eugene, III, Bakkour, Waseem, Bala, Harini Rajgopal, Balasubramaniam, Periasamy, Baltz, Julia, Banerjee, Abhijit, Bank, Ali, Bardhan, Ajoy, Bartlett, Brenda L., Bartsch, Megan, Basu, Tanya N., Belazarian, Leah, Bello, Ysabel M., Benton, E. Claire, Berbis, Philippe, Berger, Jeffrey, Berkowitz, Eric, Bernhard, Jeffrey D., Bernstein, Daniel, Bewley, Anthony, Bhushan, Monica, Bialy, Tracy, Bibi, Yuval, Bilsland, David J., Blackwell, Verity, Bornstein, Elana, Borysiewicz, Catherine, Bos, Jan D., Bowman, Paul H., Brauner, Gary J., Brooke, Rebecca C.C., Bruce, Alison J., Buchholz, Robin, Burd, Robert M., Burge, Susan M., Byrd-Miles, Katina, Campbell, Caren, Carruthers, Robert, Carucci, John A., Castelo-Soccio, Leslie, Cave, Bridgette, Centurion, Santiago A., Chachkin, Samuel L., Chadwick, Preston W., Chalmers, Robert J.G., Chang, Yuchl C., Chayavichitsilp, Pamela, Chen, Chen “Mary”, Cheung, Lawrence, Zhen Chiang, Nicole Yi, Chiaravalloti, Anthony J., Chong, Alvin H., Chu, Anthony C., Clark, Sheila M., Clayton, Timothy H., Cliff, Sandeep H., Cockrell, Clay J., Conrad, Nicole, Cooper, Susan M., Correnti, Christina M., Council, M. Laurin, Cowper, Shawn E., Cox, Neil H., Craven, Nicholas M., Creamer, Daniel, Cunliffe, William, Curry, Mary L., Dalton, Jack F., Dasgeb, Bahar, Davis, Rosie, Dawber, Rodney, Deng, Min, Desai, Avani D., Desai, Nisha C., Devlin, Georgina, Diamantis, Stephanie A., Diaz, Camilo, Dick, Sarah E., DiRusso, Lori M., Doctoroff, Alexander, Dortzbach, Kathryn, Dowd, Pauline, Drage, Lisa A., Dyche, Jacqueline A., Eke, Ure, Ellis, Natalie N., Emer, Jason J., Eminger, Lindsay A., Ensanyat, Shaheen H., Faergemann, Jan, Falabella, Anna F., Fanelli, Matthew, Farquharson, Nina R., Farsani, Terry T., Feingold, Anat, Felner, Alyssa M., Ferguson, James, Fernández, Geover, Ferzli, Pascal G., Fiandeiro, Pamela, Firoz, Elnaz F., Fischer, Michael, Fitzpatrick, James E., Fleischmayer, Raul, Frankel, Stacey, Friedlander, Philip, Fuchs, Brian S., Gagna, Claude E., Levine, Erika Gaines, Galan, Anjela, Galaria, Noreen Ahmad, Gamboni, Sarah E., Gardner, Loma S., Garg, Amit, Garza, Reed M., Gelfand, Joel M., Geller, Lauren, Gelmetti, Carlo M., Ghazi, Elizabeth, Ghunawat, Sneha, Ghura, Harvinder, Gibbs, Sam, Gibson, Gillian E., Goldenberg, Gary, Gonzales, Darrell W., Goodfield, Mark J.D., Gordon, Marsha L., Gordon, Patricia Mary, Gordon, Rachel A., Grabell, Daniel A., Graham-Brown, Robin A.C., Greaves, Malcolm W., Green, Justin J., Grelck, Kurt W., Griffiths, Christopher E.M., Gropper, Jaime R., Gruber, Pascale, Guidry, Jacqueline A., Gupta, Arpeta, Gupta, Girish, Gurtman, Alejandra, Hadi, Ahmed S., Hafejee, Abdul, Hague, Joanne, Haimowitz, Julia E., Handfield-Jones, Susan E., Zhu, Tian Hao, Harper, Natasha, Harper, John, Harris, Ronald M., Harrison, Shannon, Hatch, Michael M., Hawk, John L.M., Heagerty, Adrian H.M., Fernandez, Kristen Heins, Helms, Amy E., Henderson, Catriona A., Henry, Patricia A., Higgins, Claire L., Higgins†, Elisabeth M., Hodulik, Sarah, Hönigsmann, Herbert, Houk, Laura, Houpt, Karen R., Hruza, George J., Hui, Andrea, Humphreys, Frances, Huo, Ran, Hwang, Linda Y., Ilchyshyn, Andrew, Ilyas, Erum N., Ismail, Dina, Jablonska, Stefania, Javed, Aysha, Jing, Wei, Jolliffe, Victoria, Jones, Stephen K., Jorizzo, Joseph L., Junkins-Hopkins, Jacqueline M., Kaffenberger, Jessica, Kamenshchikov, Aleksey, Kannee, Carmen E., Kantor, Jonathan, Kasparis, Christos, Kaur, Manjit, Kaye, Keith, Kazlow, Dana, Keefe, Martin, Kellen, Roselyn, Khan, Murtaza, Kia, Kevin F., Skelsey, Maral Kibarian, Kihiczak, George G., Kim, Ho Jin, Kim, Sam, Kirby, Brian, Kirtschig, Gudula, Klein, Rachel S., Kleinerman, Rebecca, Kleydman, Kate, Kluk, Justine, Knopp, Eleanor A., Knowles, Sandra R., Kohorst, John J., Kopf, Alfred W., Korman, Neil J., Krafchik, Bernice R., Krishnan, Anjeli, Krupnick, Amy, Kupetsky, Erine A., Lamba, Sumedha, Lambert, W Clark, Langmuir, Peter, Langtry, James A.A., Larian, Amir A., Larocca, Cecilia A., Lawrence, Clifford M., Layton, Alison, Lee, Andrew D., Lee, Chai Sue, Lee, Robert E., Lessin, Stuart R., Levin, Joshua M., Levin, Robin M., Li, Hong, Liu, Kristina J., Loftus, Frances, Loosemore, Michael P., Lui, Edward, Lushniak, Boris D., Macedo, Chrystalla, Maderal, Andrea D., Mailhot, Jeffrey, Majewski, Slawomir, Majmudar, Vallari, Mann, Ranon, Manning, Jamie R., Mansouri, Yasaman, Margolis, David J., Markoff, Sarah, Marks, Ronald, Marmur, Ellen S., Marraiki, Najat A.Y., Marsden, Jeremy R., Marsland, Alexander, Martin-Clavijo, Agustin, Martinez, Anna, Matiz, Catalina, McAllister, Susan Coutinho, McDonagh, Andrew J.G., McFadden, John, McGinnis, Karen S., McKenna, Dermot B., McKerrow, Kevin, Mehmi, Manjeet, Mendonca, Corinna, Metz, Brandie J., Millard, Leslie G., Miller, James E., Miller, Jason H., Millett, Christian R., Milligan, Alex, Mimouni, Daniel, Minni, John, Mirza, Sultan A., Molin, Sonja, Montie, Dwayne, Morales-Burgos, Adisbeth, Morel, Patrice, Morison, Warwick L., Mortimer, Peter S., Motley, Richard J., Mowad, Christen M., Mowbray, Megan, Muncaster, Anna E., Murakawa, George J., Murray, Stuart C., Nabatian, Adam S., Nalluri, Rajani, Nasca, Maria R., Nawas, Zeena Y., Nayeemuddin, Farzana, Nazarlan, Rachel, Neill, Sallie, Newton-Bishop, Julia, Shim, Tang Ngee, Nguyen, Adam V., Nguyer, Patricia, Nousari, Carlos H., O’Brien, Jack C., O’Donoghue, Nuala, O’Driscoll, John B., O’Shea, Sally Jane, Ogboll, Malobl, Ogden, Stephanie, Owen, Caroline M., Paller, Amy, Palmer, Roy A., Pan, Michael, Panting, Katherine, Pappas-Taffer, Lisa, Patalay, Rakesh, Patel, Gopi, Patel, Nisha C., Paul, Jose, Payette, Michael, Piliang, Melissa Peck, Peck, Gary L., Pena, Sandra, Peranteau, Jarad, Pereira, Frederick A., Perkins, William, Perlis, Clifford S., Piraccini, Bianca Maria, Pittelkow, Mark, Pop, Samantha R., Porcu, Pierluigi, Pote, Amy, Powell, James B., Prok, Lori D., Pyle, Tia M., Qazaz, Surod, Rajkomar, Vikram, Rajpar, Sajjad F., Ramirez, Claudia C., Rapini, Ronald P., Ravitskiy, Larisa, Reddick, Tanya, Regula, Christie G., Reynolds, Rachel V., Richard, Elisabeth, Roberts, Brandie J., Roberts, David T., Rogers, Roy S., III, Rogge, Megan, Roling, Daniel, Rosenfeld, David, Payne, Christopher Rowland, Rubin, Adam I., Rubin, Courtney, Rudikoff, Donald, Ruzicka, Thomas, Sahu, Malini, Salvaggio, Heather L., Samimi, Sara, Sanchez, Miguel R., Sapadin, Allen, Scarff, Cate, Schachner, Lawrence A., Scheinfeld, Noah, Schlosser, Bethanee J., Schofield, Olivia M.V., Kirby, Joslyn Sciacca, Segal, Elana T., Selkin, Bryan A., Sexton, Daniel J., Seymour, Jamie, Shaver, Christine M., Shergil, Bav, Siegel, Julia, Silverman, Robert, Singer, Elisha, Singh, Saurabh, Sladden, Chris, Sladden, Michael, Smith, Andrew G., Smucker, Joanne E., Somani, Najwa, Sommerlad, Mary, Soon, Christine, Sopkovich, Jennifer A., Spencer, James M., Spielvogel, Richard L., Stalkup, Jennifer R., Staughton, Richard C.D., Stege, Helger, Sterling, Jane C., Stibich, Adam S., Suchin, Elliot, Suchin, Karen, Summey, Brett T., Jr, Takwale, Anita, Talhari, Carolina, Tan, Jianyou, Tan, Mei-Hing, Tarlow, Mordechai M., Taylor, Lynsey, Telfer, Nicholas R., Ter Poorten, Maryanna C., Thai, Keng-Ee, Thiers, Bruce H., Thomas, Lucy J., Thomson, Michelle A., Thornton, Cody R., Tobin, Anne-Marie, Tremaine, Anne Marie, Tripp, Jackie M., Tristani-Firouzi, Payam, Tsatsou, Fragkiski, Tucker, William F.G., Udkoff, Jeremy, Unger, Robin H., Unger, Walter P., Utz, Sarah, Valbuena, Martha C., Vangipuram, Ramya, Veitch, David, Venning, Vanessa, Versteeg, Sarah G., Vidal, Claudia Irene, Viera, Martha, Vlachou, Christina, Waldorf, Heidi A., Wali, Gorav N., Wallach, Frances, Wan, Joy, Ward, Jon R., Weidmann, Anja K., Wesley, Carlos K., West, Dennis, Wharton, James R., Whittaker, Sean J., Wiener, Adam H., Wilkin, Nathaniel K., Williams, Jason, Boucher, Kari Williamson, Winhoven, Sandra M., Wiss, Karen, Witkowski†, Joseph A., Wojnarowska, Fenella, Wong Millsop, Jillian W., Wong, Henry K., Woodall, Timothy, Wriston, Cooper C., Wu, Benedict C., Wulkan, Adam, Yates, Victoria M., Lam, Wing Yin, Young, Helen S., Zaghloul, Sameh S., Zeichner, Joshua A., Zell, Deborah, and Zouboulis, Christos C.

Published
2022
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31. List of Contributors

Author

Abdullah, Anthony, Admani, Shehla, Ahmed, Imtiaz, Hammadi, Anwar Al, Allen, Caroline P., Allen, Robert A., Ameen, Mahreen, Amini, Sadegh, Anderson, Bryan E., Anhalt, Grant J., Anyanwu, Cynthia O., Aouthmany, Mouhammad, Aslam, Arif M., Bain, E. Eugene, III, Baker, Donald J., Bakkour, Waseem, Banach, David, Baran, Robert L., Barkham, Melissa C., Basu, Tanya N., Bello, Ysabel M., Benton, Emma, Bergfeld, Wilma F., Berkowitz, Eric, Berman, Brian, Bernhard, Jeffrey D., Berth-Jones, John, Bewley, Anthony, Bhate, Chinmoy, Bhatia, Bhavnit K., Blume, Jonathan E., Brauner, Gary J., Brodell, Robert T., Brown, Marc D., Burd, Robert M., Burdick, Anne E., Burge, Susan M., Callen, Jeffrey P., Camacho, Ivan D., Campbell, Caren, Caplivski, Daniel, Cappell, Mitchell S., Carucci, John A., Casey, Genevieve A., Castelo-Soccio, Leslie, Chadwick, Preston W., Chalmers, Robert J.G., Chan, Loi-Yuen, Chan, Lawrence S., Chayavichitsilp, Pamela, Chen, Jennifer K., Child, Fiona J., Chu, Anthony C., Clayton, Timothy H., Cohen, Steven R., Cooper, Elizabeth A., Cooper, Susan M., Coulson, Ian, Cowper, Shawn E., Craven, Nicholas M., Creamer, Daniel, Cruz, Ponciano D., Jr, Cunningham, Carol, Cusack, Carrie Ann R., Davis, Mark D.P., Davis, Rosie, Dawe, Robert S., D'Cruz, David P., de Berker, David, DeHoratius, Danielle M., Desai, Nisha C., DiGiovanna, John J., Doctoroff, Alexander, Eichenfield, Lawrence F., Eisen, Drore, Eke, Ure, Elston, Dirk M., Emanuel, Patrick O.M., Emer, Jason J., Eminger, Lindsay A., Ensanyat, Shaheen H., Falabella, Anna F., Fanelli, Matthew, Farquharson, Nina R., Farsani, Terry T., Fett, Nicole, Fiandeiro, Pamela, Finlay, Andrew Y., Firoz, Bahar F., Firoz, Elnaz F., Fitzpatrick, James E., Flischel, Amy E., Freedman, Derek, Friedlander, Philip, Friedman, Adam, Fuchs, Brian S., Fukaya, Eri, Fuller, L. Claire, Gach, Joanna E., Galan, Anjela, Gamboni, Sarah E., Gardner, Loma S., Garg, Amit, Garza, Reed M., Gelfand, Joel M., Gelmetti, Carlo, Goldberg, Leonard H., Goodfield, Mark J.D., Gordon, Marsha L., Gordon, Rachel A., Graham-Brown, Robin A.C., Grattan, Clive E.H., Greaves, Malcolm W., Green, Justin J., Grelck, Kurt W., Griffiths, Christopher E.M., Gropper, Charles A., Gropper, Jaime R., Guidry, Jacqueline A., Gupta, Aditya K., Hadi, Ahmed S., Hadi, Suhail M., Hairston, Bethany R., Halpern, Analisa Vincent, Halverstam, Caroline, Handfield-Jones, Susan E., Harrison, Shannon, Heagerty, Adrian H.M., Hebert, Adelaide A., Helms, Stephen E., Hexsel, Camile L., Hexsel, Doris M., Heymann, Warren R., Higgins, Elisabeth M., High, Whitney A., Hönigsmann, Herbert, Horenstein, Marcelo G., Hui, Andrea, Humphreys, Frances, Huo, Ran, Ibbotson, Sally H., Ibrahim, Sherrif F., Ilchyshyn, Andrew, Jablonska, Stefania, Jacobe, Heidi T., James, William D., Javed, Aysha, Jemec, Gregor B.E., Johnston, 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Published
2014
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38. WITHDRAWN: Interventions for guttate psoriasis.

Author

Chalmers R, O'Sullivan T, Owen CM, and Griffiths CE

Abstract

Background: Guttate psoriasis is a distinctive acute form of psoriasis which characteristically occurs in children and young adults. Very little specific evidence-based guidance is available in standard texts to help make rational decisions about treatment options., Objectives: To assess the effectiveness of treatments for guttate psoriasis., Search Methods: We searched the Cochrane Clinical Trials Register (Cochrane Library, Issue 3, 1999), Medline (1966- September 1999), Embase (1988-September 1999), Salford Database of Psoriasis Trials (to November 1999) and European Dermato-Epidemiology Network (EDEN) Psoriasis Trials Database (to November 1999) for terms GUTTATE and PSORIASIS. We also searched 100 unselected RCTs of psoriasis therapy and all 112 RCTs of phototherapy for psoriasis in the Salford Database of Psoriasis Trials for separate stratification for guttate psoriasis., Selection Criteria: Randomised trials in which patients with acute guttate psoriasis were randomised to different treatments, except those trials examining antistreptococcal interventions which are addressed in a separate Cochrane review., Data Collection and Analysis: Two reviewers independently assessed trial eligibility and quality., Main Results: No published report could be found to support or to challenge current commonly used methods of management.Only one trial which met the selection criteria was identified. In this small study of 21 hospitalised patients with guttate psoriasis, intravenous infusion of an n-3 fatty acid rich lipid emulsion was compared with placebo emulsion containing n-6 fatty acids. The n-3 preparation appeared to be of some benefit for patients with guttate psoriasis., Authors' Conclusions: There is currently no firm evidence on which to base treatment of acute guttate psoriasis. Studies comparing standard treatment modalities, including phototherapy and topical regimens, are required to enable informed decisions on treatment choices to be made.

Published
2019
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39. WITHDRAWN: Antistreptococcal interventions for guttate and chronic plaque psoriasis.

Author

Owen CM, Chalmers R, O'Sullivan T, and Griffiths CE

Subjects
Chronic Disease, Humans, Psoriasis microbiology, Streptococcal Infections complications, Tonsillitis complications, Anti-Bacterial Agents therapeutic use, Psoriasis therapy, Streptococcal Infections prevention & control, Tonsillectomy
Abstract

Background: Guttate psoriasis is a distinctive acute form of psoriasis which characteristically occurs in children and young adults. It is closely associated with preceding streptococcal sore throat or tonsillitis. Some authorities have claimed that ordinary (chronic plaque) psoriasis may also be made worse by infection at distant sites. Although many dermatologists have recommended using antibiotics for guttate psoriasis in particular, it is not clear whether they influence the course of either form of psoriasis. Some dermatologists have also recommended tonsillectomy for psoriasis in patients with recurrent streptococcal sore throat., Objectives: To assess the evidence for effectiveness of antistreptococcal interventions including antibiotics and tonsillectomy in the management of acute guttate and chronic plaque psoriasis., Search Methods: We searched the Cochrane Clinical Trials Register (Cochrane Library, Issue 3, 1999), Medline (1966- September 1999), Embase (1988-September 1999), the Salford Database of Psoriasis Trials (to November 1999) and the European Dermato-Epidemiology Network (EDEN) Psoriasis Trials Database (to November 1999) for terms [STREPTOCOCC* or ANTIBIOTIC* or TONSIL*] and PSORIASIS using the Cochrane Skin Group search strategy., Selection Criteria: Randomised trials of one or more antistreptococcal interventions in patients with guttate or chronic plaque psoriasis., Data Collection and Analysis: Two reviewers independently examined each retrieved trial for eligibility and quality., Main Results: The one eligible trial we identified compared the use of two oral antibiotic schedules in 20 psoriasis patients, predominantly of guttate type, who had evidence of beta-haemolytic streptococcal colonisation. Either rifampicin or placebo was added to the end of a standard course of antistreptococcal antibiotic (phenoxymethylpenicillin or erythromycin). No patient in either arm of the study improved during the observation period.No randomised trials of tonsillectomy for psoriasis were identified., Authors' Conclusions: Although it is well known that guttate psoriasis may be precipitated by streptococcal infection, there is no firm evidence to support the use of antibiotics either in the management of established guttate psoriasis or in preventing the development of guttate psoriasis following streptococcal sore throat.Although both antibiotics and tonsillectomy have frequently been advocated for patients with recurrent guttate psoriasis or chronic plaque psoriasis, there is to date no good evidence that either intervention is beneficial.

Published
2019
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