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6 results on '"Owais Kadwani"'

1. Clinical and survival differences during separate COVID-19 surges: Investigating the impact of the Sars-CoV-2 alpha variant in critical care patients.

Author

Andrew I Ritchie, Owais Kadwani, Dina Saleh, Behrad Baharlo, Lesley R Broomhead, Paul Randell, Umeer Waheed, Maie Templeton, Elizabeth Brown, Richard Stümpfle, Parind Patel, Stephen J Brett, and Sanooj Soni

Subjects
Medicine, Science
Abstract

A number of studies have highlighted physiological data from the first surge in critically unwell Covid-19 patients but there is a paucity of data describing emerging variants of SARS-CoV-2, such as B.1.1.7. We compared ventilatory parameters, biochemical and physiological data and mortality between the first and second COVID-19 surges in the United Kingdom, where distinct variants of SARS-CoV-2 were the dominant stain. We performed a retrospective cohort study investigating critically unwell patients admitted with COVID-19 across three tertiary regional ICUs in London, UK. Of 1782 adult ICU patients screened, 330 intubated and ventilated patients diagnosed with COVID-19 were included. In the second wave where B.1.1.7 variant was the dominant strain, patients were had increased severity of ARDS whilst compliance was greater (p

Published
2022
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2. A vascular cause of unexplained exertional wheeze: Keeping a high index of suspicion

Author

Owais Kadwani, Oliver J. Price, Samuel V. Kemp, Cesare Quarto, and James H. Hull

Subjects
Diseases of the respiratory system, RC705-779
Abstract

A 31-year-old female was referred with a history of unexplained exertional breathlessness. The patient had normal resting lung function and a CT thorax showed no significant abnormality. Closer scrutiny of the flow-volume loop confirmed an elevated Empey's index. Cardiopulmonary exercise testing with continuous laryngoscopy was conducted to evaluate the upper airway response to exercise which confirmed loud biphasic wheeze. A bronchoscopy revealed no stenosis nor intraluminal narrowing, however, a contrast CT confirmed a right-sided aortic arch and aberrant left subclavian artery. Following multidisciplinary review, the patient opted for a surgical approach to treatment however despite initially reporting an improvement in symptoms and exercise capacity continued to suffer exertional wheeze two-years post-surgery. This clinical report describes a rare vascular cause of exertional wheeze but also provides a cautionary note in terms of providing a guarded prognosis for adults undergoing surgical intervention for tracheal compression arising from congenital vascular abnormalities. Keywords: Dyspnoea, Cough, Trachea, Wheeze, Bronchoscopy

Published
2020
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3. Clinical and survival differences during separate COVID-19 surges: Investigating the impact of the Sars-CoV-2 alpha variant in critical care patients

Author

Andrew I. Ritchie, Owais Kadwani, Dina Saleh, Behrad Baharlo, Lesley R. Broomhead, Paul Randell, Umeer Waheed, Maie Templeton, Elizabeth Brown, Richard Stümpfle, Parind Patel, Stephen J. Brett, Sanooj Soni, The Academy of Medical Sciences, and British Journal of Anaesthesia

Subjects
Adult, Respiratory Distress Syndrome, Multidisciplinary, Critical Care, General Science & Technology, SARS-CoV-2, COVID-19, Humans, Prospective Studies, Retrospective Studies
Abstract

A number of studies have highlighted physiological data from the first surge in critically unwell Covid-19 patients but there is a paucity of data describing emerging variants of SARS-CoV-2, such as B.1.1.7. We compared ventilatory parameters, biochemical and physiological data and mortality between the first and second COVID-19 surges in the United Kingdom, where distinct variants of SARS-CoV-2 were the dominant stain. We performed a retrospective cohort study investigating critically unwell patients admitted with COVID-19 across three tertiary regional ICUs in London, UK. Of 1782 adult ICU patients screened, 330 intubated and ventilated patients diagnosed with COVID-19 were included. In the second wave where B.1.1.7 variant was the dominant strain, patients were had increased severity of ARDS whilst compliance was greater (p

Published
2021

4. Utility of pleural fluid glucose measurement in TB pleural effusions

Author

Junyi Zhang, Liju Ahmed, Ronan Breen, Charlotte Carter, Sundeep Ghuman, and Owais Kadwani

Subjects
medicine.medical_specialty, business.industry, Pleural tuberculosis, Extrapulmonary tuberculosis, Glucose Measurement, Pleural infection, respiratory system, Gastroenterology, respiratory tract diseases, Internal medicine, Pleural fluid, Medicine, Biomarker (medicine), In patient, business, Biopsy culture
Abstract

Background: Tuberculous pleural infection is the most common form of extrapulmonary TB infection. Pleural fluid glucose has been used to aid diagnosis of bacterial pleural infections including TB however the data for its utility in pleural TB is limited. Aim: To identify the utility of pleural fluid glucose as a biomarker in the diagnosis of TB pleural infections. Methods: We conducted a retrospective case series collection of 106 patients diagnosed with pleural Tuberculosis at a tertiary pleural service from 2010 to 2019. All patients received treatment for TB as per UK national guidelines adjusted to culture sensitivities. Results: 106 patients were initially included, with 12 excluded due to insufficient data. A total of 64/94 patients had pleural fluid sent for glucose measurement. All but 2 patients had a pleural fluid glucose less than 7mmol/L. 39/64 (61%) patients had a pleural fluid glucose ranging 4.1-6.0mmol/L and 20/64 (31%) patients had a pleural fluid glucose of Conclusion: Pleural fluid glucose appears to be low in patients who are pleural fluid or biopsy culture positive, however it is not significantly lower when compared to all patients with TB pleural infection. Therefore unlike in other bacterial pleural infections, we suggest that pleural fluid glucose may not be a useful marker in aiding the diagnosis of pleural TB infection.

Published
2020

6. Pleural procedures: training the trainee

Author

Zhe Wu and Owais Kadwani

Subjects
medicine.medical_specialty, business.industry, education, medicine, Medical physics, General Medicine, General hospital, business, Education, Training and medical professionalism
Abstract

Two respiratory registrars with level 1 ultrasound competency aimed to set up a service to provide supervised pleural procedures training for trainees at a district general hospital. An initial online survey was sent out via email to gauge trainees’ interest, their level of previous experience in

Published
2019

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