9 results on '"Ovidiu Grama"'
Search Results
2. Patients with diabetes at risk in COVID-19 pandemic
- Author
-
Réka Toth, Mihaela Chincesan, Ovidiu Grama, and Alina Grama
- Subjects
sars-cov-2 ,infection ,covid-19 ,pandemic ,comorbidity ,diabetes mellitus ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
The new coronavirus infection (COVID-19) spread rapidly from the outbreak in Wuhan, China with a wide range of clinical manifestations, from asymptomatic to fatal. Individuals from the risk factor category, including those with diabetes mellitus (DM), have a proven higher risk of developing a severe form of the disease, as well as a higher risk of mortality. Through this summary we aim to briefly review the general characteristics of COVID-19 and a special situation, namely that of infection in patients with diabetes. We addressed the potential mechanisms that may increase the susceptibility of diabetic patients to COVID-19, but also the current recommendations in Romania for diabetics in the COVID-19 pandemic. Based on current limited evidence we cannot draw conclusions. Further research on this association between COVID-19 and DM is necessary and justified.
- Published
- 2020
- Full Text
- View/download PDF
3. Pacienţii cu diabet zaharat la risc în pandemia COVID-19
- Author
-
Réka Toth, Mihaela Chinceșan, Ovidiu Grama, and Alina Grama
- Subjects
sars-cov-2 ,infecţie ,covid-19 ,pandemie ,comorbiditate ,diabet zaharat ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Infecţia cu noul coronavirus (COVID-19) s-a răspândit rapid din focarul Wuhan, China având un spectru larg de manifestări clinice, de la cazuri asimptomatice până la cele fatale. Indivizii din categoria cu factori de risc, printre care și cei cu diabet zaharat (DZ), au un risc demonstrat mai mare de a dezvolta o formă de boală severă, precum și un risc mai mare de mortalitate. Prin acest articol ne-am propus să revizuim pe scurt caracteristicile generale ale COVID-19 și o situaţie specială, cea de infecţie la pacienţi cu DZ. Am abordat mecanismele potenţiale care pot crește susceptibilitatea pacienţilor diabetici pentru COVID-19, dar și recomandările actuale din România pentru diabetici în pandemia COVID-19. Pe baza dovezilor actuale, limitate, nu putem deduce concluzii, cercetări ulterioare cu privire la această asociere între COVID-19 și DZ sunt necesare și justificate.
- Published
- 2020
- Full Text
- View/download PDF
4. Stafilococia cutanată la nou-născut – abordare clinică şi tratament
- Author
-
Réka Toth, Mihaela Chinceşan, Ovidiu Grama, Septimiu Voidăzan, and Alina Grama
- Subjects
nou-născut ,sindromul stafilococic al pielii opărite (ssss) ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Introducere. Sindromul stafilococic al pielii opărite (SSSS) este o boală exfoliantă a pielii cu două perioade de incidență: perioada neonatală şi copilăria timpurie. Diagnosticul diferențial include impetigo bulos, sindromul Stevens-Johnson, necroliza epidermică toxică (TEN), sindromul şocului toxic, scarlatina, boala Kawasaki şi pemfigusul. Prezentare de caz. Prezentăm un nou-născut în vârstă de 14 zile, sex feminin, mediu rural, internat în Clinica de Pediatrie pentru apariția unor erupții cutanate veziculoase la nivelul frontal şi al feței, care se extind către torace, abdomen şi membre, cu zone de descuamare, respectiv iritabilitate. Diagnosticul pozitiv de SSSS a fost susținut pe baza anamnezei (perforarea lobulilor auriculari, debut rapid al veziculelor care se măresc şi se rup), a examenului clinic (vezicule şi bule laxe, multiple, semn Nikolsky prezent, cruste periorale, conjunctivită cu secreții purulente, eritem şi edem palpebral bilateral) şi paraclinic (secreție din leziuni – floră saprofită; secreție conjunctivală – Staphylococcus aureus MSSA) şi a răspunsului terapeutic. Sub tratament antibiotic parenteral, reechilibrare hidro-electrolitică, igienă locală riguroasă, evoluția a fost favorabilă. Concluzii. Staphylococcus aureus este un agent patogen important în perioada neonatală. Diagnosticul şi tratamentul rapid al infecției, cu diseminare hematogenă la piele, sunt necesare pentru a reduce morbiditatea şi mortalitatea.
- Published
- 2020
- Full Text
- View/download PDF
5. Staphylococcal cutaneous infection in newborn – clinical approach and treatment
- Author
-
Reka Toth, Mihaela Chincesan, Ovidiu Grama, Septimiu Voidazan, and Alina Grama
- Subjects
newborn ,staphylococcal scalded skin syndrome (ssss) ,Medicine ,Infectious and parasitic diseases ,RC109-216 - Abstract
Introduction. Staphylococcal scalded skin syndrome (SSSS) is an exfoliating skin disease with two age peak incidence: the neonatal period and early childhood. Differential diagnosis includes bullous impetigo, Stevens-Johnson syndrome, Toxic epidermal necrosis (TEN), oxic shock syndrome, Scarlet fever, Kawasaki disease and Pemphigus. Case presentation. We present a 14-day-old female, from a rural area, admitted in the Pediatrics Clinic with appearance of blistering skin rash on the face and forehead, extending to the chest, abdomen and limbs, with areas of exfoliation and irritability respectively. The positive diagnosis of SSSS was made based upon the medical history (perforation of the auricular lobules, rapid onset of the vesicles that growth and break), physical findings (multiple vesicles and lax blisters, positive Nikolsky sign, perioral crusts, conjunctivitis with purulent secretions, erythema and bilateral palpebral edema) and paraclinical (lesion secretion – saprophytic flora; conjunctival secretion – Staphylococcus aureus MSSA), and adequate therapeutic response respectively. With parenteral antibiotic treatment, hydro-electrolyte rebalancing and rigorous local hygiene the evolution was favorable. Conclusions. Staphylococcus aureus is an important pathogen in the neonatal period. The appropriate diagnosis and treatment of infection with hematogenous dissemination in the skin are necessary to reduce morbidity and mortality.
- Published
- 2020
- Full Text
- View/download PDF
6. Patients with diabetes at risk in COVID-19 pandemic
- Author
-
Alina Grama, Réka Toth, Mihaela Chincesan, and Ovidiu Grama
- Subjects
medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,business.industry ,pandemic ,General Engineering ,Infectious and parasitic diseases ,RC109-216 ,medicine.disease ,infection ,sars-cov-2 ,comorbidity ,covid-19 ,Diabetes mellitus ,diabetes mellitus ,Emergency medicine ,Pandemic ,Medicine ,General Earth and Planetary Sciences ,business ,General Environmental Science - Abstract
The new coronavirus infection (COVID-19) spread rapidly from the outbreak in Wuhan, China with a wide range of clinical manifestations, from asymptomatic to fatal. Individuals from the risk factor category, including those with diabetes mellitus (DM), have a proven higher risk of developing a severe form of the disease, as well as a higher risk of mortality. Through this summary we aim to briefly review the general characteristics of COVID-19 and a special situation, namely that of infection in patients with diabetes. We addressed the potential mechanisms that may increase the susceptibility of diabetic patients to COVID-19, but also the current recommendations in Romania for diabetics in the COVID-19 pandemic. Based on current limited evidence we cannot draw conclusions. Further research on this association between COVID-19 and DM is necessary and justified.
- Published
- 2020
- Full Text
- View/download PDF
7. Pacienţii cu diabet zaharat la risc în pandemia COVID-19
- Author
-
Alina Grama, Ovidiu Grama, Réka Toth, Clinica Obstetrică-Ginecologie Ii, Spital Clinic Judeţean Mureș, Tg. Mureș, România, and Mihaela Ioana Chinceșan
- Subjects
infecţie ,sars-cov-2 ,covid-19 ,pandemie ,comorbiditate ,diabet zaharat ,General Engineering ,General Earth and Planetary Sciences ,Medicine ,Infectious and parasitic diseases ,RC109-216 ,General Environmental Science - Abstract
Infecţia cu noul coronavirus (COVID-19) s-a răspândit rapid din focarul Wuhan, China având un spectru larg de manifestări clinice, de la cazuri asimptomatice până la cele fatale. Indivizii din categoria cu factori de risc, printre care și cei cu diabet zaharat (DZ), au un risc demonstrat mai mare de a dezvolta o formă de boală severă, precum și un risc mai mare de mortalitate. Prin acest articol ne-am propus să revizuim pe scurt caracteristicile generale ale COVID-19 și o situaţie specială, cea de infecţie la pacienţi cu DZ. Am abordat mecanismele potenţiale care pot crește susceptibilitatea pacienţilor diabetici pentru COVID-19, dar și recomandările actuale din România pentru diabetici în pandemia COVID-19. Pe baza dovezilor actuale, limitate, nu putem deduce concluzii, cercetări ulterioare cu privire la această asociere între COVID-19 și DZ sunt necesare și justificate.
- Published
- 2020
8. Transvaginal Ultrasound Combined with Strain-Ratio Elastography for the Concomitant Diagnosis of Uterine Fibroids and Adenomyosis: A Pilot Study
- Author
-
Vlăduț Săsăran, Sabin Turdean, Claudiu Mărginean, Marius Gliga, Levente Ilyes, Ovidiu Grama, and Lucian Pușcașiu
- Subjects
uterine fibroid ,adenomyosis ,trans-vaginal ultrasonography ,strain ratio elastography ,General Medicine - Abstract
Uterine fibroids (UFs) and adenomyosis (AM) represent two benign uterine conditions that can affect fertility and are most frequently commonly responsible for abnormal uterine bleeding and chronic pelvic pain. Their differential diagnosis still represents a challenge, and several authors advise the addition of elastography to transvaginal ultrasound (TVUS) for a more accurate imagistic recognition. Through this study, we aimed to assess the diagnostic accuracy of TVUS combined with strain-ratio elastography (SRE) in concomitant AM and UFs. We conducted a study on 17 patients diagnosed with concomitant UFs and AM undergoing hysterectomy and 46 healthy patients. TVUS combined with SRE was conducted in each patient, focusing on identifying rigidity patterns of the lesions. Significantly higher mean SR and maximum SR values were identified among both AM and UF lesions as opposed to controls (p < 0.01), with the highest tissue stiffness being encountered among AM lesions, which allows for the differentiation of UF (p < 0.01) and concomitant identification of both lesions. These results are reflected by higher cut-off values obtained for AM, both for mean SR (5.42 vs. 2.85) and maximum SR (5.80 vs. 3.30). TVUS combined with SRE showed good diagnostic performance in identifying coexisting UFs and AM within the same uterine specimen. Future studies on wider populations are required to validate our findings.
- Published
- 2022
9. Value of Strain-Ratio Elastography in the Diagnosis and Differentiation of Uterine Fibroids and Adenomyosis
- Author
-
Sabin Turdean, Mihai Muntean, Marius Gliga, Lucian Pușcașiu, Vladut Săsăran, Ovidiu Grama, and Levente Ilyes
- Subjects
Hysterectomy ,medicine.diagnostic_test ,Receiver operating characteristic ,business.industry ,Uterine fibroids ,medicine.medical_treatment ,Medicine (miscellaneous) ,medicine.disease ,Article ,Uterine Disorder ,transvaginal ultrasound ,adenomyosis ,medicine ,Medicine ,Cutoff ,Adenomyosis ,Elastography ,Differential diagnosis ,uterine fibroids ,Nuclear medicine ,business ,strain ratio elastography - Abstract
Benign uterine disorders, including uterine fibroids (UF) and adenomyosis (AM), can impact the life quality and fertility of women of reproductive age. Transvaginal ultrasound (TVUS) has long been used for their early identification, but its combined use with elastography seems to improve diagnostic accuracy of UF and AM. Thus, a prospective pilot study was conducted on 79 patients who underwent hysterectomy (25 microscopically diagnosed with AM and 53 with UF), with the aim of assessing the ability of TVUS combined with strain ratio elastography (SE) to accurately diagnose and distinguish UF and AM. Significantly higher mean and maximal strain ratio (SR) values were identified for patients with histologically confirmed AM as opposed to those with UF (p <, 0.001). Diagnostic sensitivity and specificity, calculated in comparison with histology results, were higher for UF than AM. Receiver operating characteristic (ROC) analysis was applied between the two study groups, revealing cutoff values of 7.71 for mean SR and 8.91 for maximal SR, respectively, with good sensitivity and specificity parameters (100% and 96.23%, 96% and 96.23%). Our results support the use of TVUS in combination with SE for the positive and differential diagnosis of UF and AM, through identification of their particular tissue stiffness features.
- Published
- 2021
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.