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2 results on '"Ovidiu Ghirlea"'

1. The Great Saphenous Vein Proximal Part: Branches, Anatomical Variations, and Their Implications for Clinical Practice and Venous Reflux Surgery

Author

Krisztina Munteanu, Ovidiu Ghirlea, Daniel Breban-Schwarzkopf, Alexandra-Ioana Dănilă, Roxana-Georgeta Iacob, Ioan Adrian Petrache, Gabriel Veniamin Cozma, Anca Bordianu, and Sorin Lucian Bolintineanu

Subjects
lower limb vein anatomy, tributaries, venous aneurysm, anterior accessory great saphenous vein, venous reflux, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

The anatomical variations in the lower limb veins play a critical role in venous reflux surgeries. This study presents an analysis of the great saphenous vein (GSV) proximal part’s anatomical peculiarities, with 257 patients included, who were operated for venous reflux. This study highlighted a progressive increase in the GSV diameter in conjunction with the complexity of the anatomical variations, ranging from no tributaries to more than five tributaries, an anterior accessory GSV, or venous aneurysms. Statistical analysis evidenced this expansion to be significantly correlated with the variations. Additionally, the progression of the chronic venous disease (CVD) stages was notably more prevalent in the complex anatomical variations, suggesting a nuanced interplay between the GSV anatomy and CVD severity. Conclusively, our research articulates the paramount importance of recognizing GSV anatomical variations in optimizing surgical outcomes for CVD patients. These insights not only pave the way for enhanced diagnostic accuracy but also support the strategic framework within which surgical and interventional treatments are devised, advocating for personalized approaches to venous reflux surgery.

Published
2024
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2. Gastrointestinal stromal tumor. A case report with over 5 years follow-up

Author

Andrei, Parau, Ovidiu, Ghirlea, Sonia, Ratiu, Cosmin, Dragomir, and Sorin, Olariu

Subjects
Gastrointestinal Stromal Tumors, Humans, Tyrosine, Neoplasm Recurrence, Local, Prognosis, Follow-Up Studies
Abstract

Gastro-intestinal stromal tumors (GIST) represent a type of mesenchymal tumors, located in the digestive tract wall, with the possibility of alternate locations such as the caul or the mesentery. The relapse prognosis is closely corelated with the dimensions of the tumor, the rate at which tumor cells divide, the cellularity of the tumor and the nuclear pleomorphism. The definitive treatment for these types of tumors is surgical resection, associated with tyrosine- kinase inhibitors.The largest gastro-intestinal stromal tumor ever recorded in medical literature measured 42/31/23 cm and weighed in at 18.5 kg. The following case presentation is of a patient aged 65 at his first admission, who received tyrosine-kinase inhibitors of different generations, associated with multiple surgical interventions for tumor cytoreduction. The case presented, according to specialty literature, is the second one as far as volume and weight of the tumor go, the tumor invading the peritoneal cavity and weighing in at approximatively 15 kg. KEY WORDS: Gist, Second largest tumor, Tyrosine-kinase inhibitors, Nuclear pleomorphism.

Published
2023

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